28-08-2014 дата публикации
Номер: US20140243334A1
This invention provides compounds of formula (I): 2. The compound of claim 1 , wherein G is —R claim 1 , —V—R claim 1 , —V-L-R claim 1 , -L-V—R claim 1 , or -L-R.3. The compound of claim 2 , wherein:{'sup': 2a', '1, 'Ris R;'}{'sup': '2b', 'Ris G;'}{'sup': 2c', '1, 'Ris R; and'}{'sup': '2d', 'sub': '1', 'Ris R.'}4. The compound of claim 2 , wherein:{'sup': 2a', '1, 'Ris R;'}{'sup': 2b', '1, 'Ris R;'}{'sup': '2c', 'Ris G; and'}{'sup': 2d', '1, 'Ris R.'}5. The compound of claim 2 , wherein:{'sub': 1', '1, 'sup': 3', '3', '3, 'G is —V—R, -L-R, or —R;'}{'sub': 1', '2', '2', '2, 'Lis —CH— or —CHCH—; and'}{'sub': 1', '2, 'sup': 4a', '4a', '4a', '4a', '4a', '4a', '4a, 'Vis —N(R)—, —N(R)—C(O)—, —C(O)—N(R)—, —N(R)—SO—, —O—, —N(R)—C(O)—O—, or —N(R)—C(O)—N(R)—.'}6. The compound of claim 2 , wherein:{'sup': '1a', 'each occurrence of Ris independently hydrogen, fluoro, trifluoromethyl, or methyl;'}{'sup': '1b', 'each occurrence of Ris hydrogen;'}{'sup': '1c', 'Ris hydrogen, hydroxy, fluoro, trifluoromethyl, or methyl;'}{'sup': '1', 'each occurrence of Ris independently hydrogen, chloro, fluoro, cyano, hydroxy, methoxy, ethoxy, trifluoromethyl, methyl, or ethyl.'}7. The compound of claim 2 , wherein:{'sup': 3', '5dd, 'each substitutable carbon chain atom in Ris unsubstituted or substituted with 1-2 occurrences of R;'}{'sup': 3', '5', '5aa, 'sub': '2', 'each substitutable saturated ring carbon atom in Ris unsubstituted or substituted with ═O, ═C(R), or —R;'}{'sup': 3', '5a, 'each substitutable unsaturated ring carbon atom in Ris unsubstituted or is substituted with —R;'}{'sup': 3', '9b, 'claim-text': [{'sup': 5a', '5', '5', '5', '5', '6', '6', '6', '4', '4', '4', '6', '4', '4', '4', '6', '4', '6', '4', '4', '6', '4', '4', '5a, 'sub': 2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '1-6, 'each Ris independently halogen, —NO, —CN, —C(R)═C(R), —C≡C—R, —OR, —SR, —S(O)R, —SOR, —SON(R), —N(R), —NRC(O)R, —NRC(O)N(R), —NRCOR, —OC(O)N(R), —C(O)R, —C(O)N(R), —N(R)SOR, —N(R) ...
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