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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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Поддерживает ввод нескольких поисковых фраз (по одной на строку). При поиске обеспечивает поддержку морфологии русского и английского языка
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Применить Всего найдено 3586. Отображено 100.
24-05-2012 дата публикации

Materials for organic electroluminescent devices

Номер: US20120126179A1
Автор: Amir Hossain Parham, Esther Breuning, Susanne Heun
Принадлежит: Merck Patent GmBH

The present invention relates to 4,4′-substituted spirobifluorenes which are suitable, owing to excellent properties, as functional materials in organic electroluminescent devices. In addition, the present invention relates to a process for the preparation of 4,4′-substituted spirobifluorenes and to the use of these compounds in organic electroluminescent devices.

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Номер записи: 1
21-06-2012 дата публикации

Cyclic compound, process for production of the cyclic compound, radiation-sensitive composition, and method for formation of resist pattern

Номер: US20120156615A1
Автор: Hiromi Hayashi, Masatoshi Echigo
Принадлежит: Mitsubishi Gas Chemical Co Inc

A cyclic compound represented by formula (1): wherein L, R 1 , R′, and m are as defined in the specification. The cyclic compound of formula (1) is highly soluble to a safety solvent, highly sensitive, and capable of forming resist patterns with good profile. Therefore, the cyclic compound is useful as a component of a radiation-sensitive composition.

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Номер записи: 2
28-06-2012 дата публикации

Cyclic compound, process for preparation thereof, radiation-sensitive composition, and method for formation of resist pattern

Номер: US20120164576A1
Автор: Dai Oguro, Hiromi Hayashi, Masatoshi Echigo
Принадлежит: Mitsubishi Gas Chemical Co Inc

A cyclic compound represented by formula (1): wherein L, R 1 , R′, and m are as defined in the specification. The cyclic compound of formula (1) is highly soluble to a safety solvent, highly sensitive, and capable of forming resist patterns with good profile. Therefore, the cyclic compound is useful as a component of a radiation-sensitive composition.

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Номер записи: 3
13-09-2012 дата публикации

Aromatic amine derivative and organic electroluminescent device using same

Номер: US20120228594A1
Автор: Hisayuki Kawamura, Nobuhiro Yabunouchi
Принадлежит: Idemitsu Kosan Co Ltd

Disclosed is an organic electroluminescence device in which an organic thin film which is composed of one or more layers including at least a light-emitting layer is interposed between a cathode and an anode. Since at least one layer of the organic thin film contains a novel aromatic amine derivative, which has an asymmetric structure wherein two different amine units are bonded through a linking group, by itself or as a component of a mixture, molecules are hardly crystallized, thereby improving the production yield of the organic electroluminescence device. This organic electroluminescence device has a long life.

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Номер записи: 4
17-01-2013 дата публикации

Synthesis and applications of soluble pentacene precursors and related compounds

Номер: US20130017497A1
Автор: Chung-Chih Wu, Hsin-Hui HUANG, Hsing-Hung HSIEH, Ta-Hsien CHUANG, Tahsin J. Chow
Принадлежит: Academia Sinica

The present disclosure relates to methods and systems for synthesis of bridged-hydropentacene, hydroanthracene and hydrotetracene from the precursor compounds pentacene derivatives, tetracene derivatives, and anthracene derivatives. The invention further relates to methods and systems for forming thin films for use in electrically conductive assemblies, such as semiconductors or photovoltaic devices.

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Номер записи: 5
14-02-2013 дата публикации

Electroluminescent materials comprising fluorene derivatives

Номер: US20130037752A1
Автор: Gene Carl Koch
Принадлежит: Lomox Ltd

OLED compounds of the general structure: B—S-A-S—B in which rod-like nuclei A includes a condensed aromatic ring structure in turn having fluorene ring structures condensed with at least one additional fluorene ring structures wherein the fluorene ring systems provided by the condensed aromatic structure are substituted at the 9-position, and in which the 9-positions of the fluorenes are not susceptible to oxidation.

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Номер записи: 6
28-03-2013 дата публикации

NORBORNANE-2-SPIRO-alpha-CYCLOALKANONE-alpha'-SPIRO-2''-NORBORNANE-5,5'',6,6''-TETRACARBOXYLIC DIANHYDRIDE, NORBORNANE-2-SPIRO-alpha-CYCLOALKANONE-alpha'-SPIRO-2''-NORBORNANE-5,5'',6,6''-TETRACARBOXYLIC ACID AND ESTER THEREOF, METHOD FOR PRODUCING NORBORNANE-2-SPIRO-alpha-CYCLOALKANONE-alpha'-SPIRO-2''-NORBORNANE-5,5'',6,6''-TETRACARBOXYLIC DIANHYDRIDE, POLYIMIDE OBTAINED BY USING THE SAME, AND METHOD FOR PRODUCING POLYIMIDE

Номер: US20130079490A1
Автор: Shinichi Komatsu, Toshihiko Matsumoto
Принадлежит: JX Nippon Oil and Energy Corp

A norbornane-2-spiro-α-cycloalkanone-α′-spiro-2″-norbornane-5,5″,6,6″-tetracarboxylic dianhydride represented by the following general formula (1): [in the formula (1), n represents an integer of 0 to 12, and R 1 s, R 2 , R 3 each independently represents a hydrogen atom or the like].

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Номер записи: 7
16-05-2013 дата публикации

Styryl-based compound, composition containing styryl-based compound, and organic light emitting diode including styryl-based compound

Номер: US20130119355A1
Автор: Dae-Yup Shin, Hye-jin Jung, Jin-O Lim, Jong-hyuk Lee, Sang-hyun Han, Seok-Hwan Hwang, Soo-Yon Kim, Young-Kook Kim
Принадлежит: Samsung Display Co Ltd

A styryl-based compound represented by Formula 1, a composition containing the styryl-based compound, and an organic light-emitting diode (OLED) including the styryl-based compound: The styryl-based compound may exhibit high heat resistance and thus an OLED including the same may have low driving voltage, high brightness, high efficiency, and long lifetime.

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Номер записи: 8
01-08-2013 дата публикации

Mglu 2/3 agonists

Номер: US20130197079A1
Автор: Barry Peter Clark, Christopher David Beadle, James Allen Monn, Lourdes Prieto, Stephen Richard Baker
Принадлежит: Eli Lilly and Co

The present invention provides novel mGlu2/3 agonists useful in the treatment of neurological or psychiatric disorders.

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Номер записи: 9
17-10-2013 дата публикации

Compound for organic light-emitting diode and organic light-emitting diode including the same

Номер: US20130270524A1
Автор: Eun-Jae Jeong, Eun-young Lee, Hye-jin Jung, Jin-O Lim, Jong-hyuk Lee, Jun-Ha Park, Sang-hyun Han, Se-Jin Cho, Seok-Hwan Hwang, Soo-Yon Kim, Young-Kook Kim
Принадлежит: Samsung Display Co Ltd

A compound represented by Formula 1 below may be used in an organic light emitting diode.

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Номер записи: 10
09-01-2014 дата публикации

Catalytic or photocatalytic preparation method of parylene af4

Номер: US20140011986A1
Автор: Chien-Yi Sun, Chun-Hsu Lin, Chun-Shih LI, Yo-Chun CHOU, Yung-Yu Yin
Принадлежит: YUAN-SHIN MATERIALS TECHNOLOGY CORP

The present invention disclosed a preparation method of parylene AF4, which provides a reactant and a reducing agent with the use of catalyst or exposure to UV light with photo-initiator, to shorten the reaction time as a result of minimized the byproduct(s) formation, and obtain high purity (>99.0%) of parylene AF4 product under high concentrated reaction mixture.

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Номер записи: 11
04-01-2018 дата публикации

DOUBLE-SPIRO TYPE COMPOUND AND ORGANIC LIGHT-EMITTING DEVICE CONTAINING SAME

Номер: US20180002256A1
Автор: Cha Yongbum, Kim Jin Joo
Принадлежит:

The present specification relates to a double spiro structure compound, and an organic light emitting device comprising the same. 3. The double spiro structure compound of claim 1 , wherein Cy1 is a substituted or unsubstituted benzene ring.4. The double spiro structure compound of claim 1 , wherein Lto Lare the same as or different from each other and each independently a direct bond; a substituted or unsubstituted phenylene group; or a substituted or unsubstituted biphenylylene group.5. The double spiro structure compound of claim 1 , wherein Arto Arare the same as or different from each other claim 1 , and each independently selected from the group consisting of a substituted or unsubstituted phenyl group; a substituted or unsubstituted biphenylyl group; a substituted or unsubstituted naphthyl group; a substituted or unsubstituted terphenyl group; a substituted or unsubstituted quaterphenyl group; a substituted or unsubstituted fluorenyl group; a substituted or unsubstituted phenanthrenyl group; a substituted or unsubstituted terphenylenyl group; a substituted or unsubstituted dibenzothiophene group; and a substituted or unsubstituted dibenzofuran group.13. An organic light emitting device comprising:an anode;a cathode provided opposite to the anode; anda light emitting layer and one or more organic material layers provided between the anode and the cathode,{'claim-ref': {'@idref': 'CLM-00001', 'claim 1'}, 'wherein the light emitting layer or one or more layers of the organic material layers comprise the double spiro structure compound of .'}14. The organic light emitting device of claim 13 , wherein the organic material layer comprises a hole injection layer or a hole transfer layer claim 13 , and the hole injection layer or the hole transfer layer comprises the double spiro structure compound.15. The organic light emitting device of claim 13 , wherein the organic material layer comprises an electron blocking layer claim 13 , and the electron blocking layer ...

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Номер записи: 12
04-01-2018 дата публикации

TRICYCLIC SPIRO COMPOUND

Номер: US20180002308A1
Автор: ASADA Masaki, FUCHIBE Kazuhiro, HIGUCHI Satonori, HIROBE Masaya, KOTANI Tohru, Oikawa Ryo, TAKANO Hirotsugu, TANI Kousuke
Принадлежит: ONO PHARMACEUTICAL CO., LTD.

A medicinal agent for the prevention and/or treatment of diseases caused by EPreceptor activation. A compound having antagonistic activity against the EPreceptor is contained as an active ingredient in the medicinal agent. The compound represented by the following general formula (I) as defined in the specification, a salt, an N-oxide, or a solvate thereof, or a prodrug of these is useful as a medicinal component having antagonistic activity against the EPreceptor for the prevention and/or treatment of diseases caused by EPreceptor activation. 3. The compound according to claim 1 , wherein at least one Ris —CONHR.4. The compound according to claim 1 , wherein Lis —NHCO— claim 1 , or —CONH—.6. The compound according to claim 1 , which is any one of the following:(1) 4-[4-cyano-2-({[(2′R,4S)-6-(methylcarbamoyl)-2,3-dihydrospiro[chromene-4,1′-cyclopropan]-2′-yl]carbonyl}amino)phenyl]butanoic acid,(2) 4-{4-cyano-2-[({(2′R,4S)-6-[(cyclopropylmethyl)carbamoyl]-2,3-dihydrospiro[chromene-4,1′-cyclopropan]-2′-yl}carbonyl)amino]phenyl}butanoic acid,(3) 4-{4-cyano-2-[({(2′R,4S)-6-[(2-methoxyethyl)carbamoyl]-2,3-dihydrospiro[chromene-4,1′-cyclopropan]-2′-yl}carbonyl)amino]phenyl}butanoic acid,(4) 4-{4-cyano-2-[({(2′R,4S)-6-[(2-methyl-2-propanyl)carbamoyl]-2,3-dihydrospiro[chromene-4,1′-cyclopropan]-2′-yl}carbonyl)amino]phenyl}butanoic acid,(5) 4-[4-cyano-2-({[(2′R,4S)-6-{[(2S)-1-methoxy-2-propanyl]carbamoyl}-2,3-dihydrospiro[chromene-4,1′-cyclopropan]-2′-yl]carbonyl}amino)phenyl]butanoic acid,(6) 4-{4-cyano-2-[({(2′R,4S)-6-[(1-methyl-1H-pyrazol-3-yl)carbamoyl]-2,3-dihydrospiro[chromene-4,1′-cyclopropan]-2′-yl}carbonyl)amino]phenyl}butanoic acid,(7) 4-[4-cyano-2-({[(2′R,4S)-6-(cyclopropylcarbamoyl)-2,3-dihydrospiro[chromene-4, 1′-cyclopropan]-2′-yl]carbonyl}amino)phenyl]butanoic acid,(8) 4-[4-cyano-2-({[(2′R,4S)-6-(isopropylcarbamoyl)-2,3-dihydrospiro[chromene-4,1′-cyclopropan]-2′-yl]carbonyl}amino)phenyl]butanoic acid,(9) 4-[4-cyano-2-({[(2′R,4S)-6-(cyclopentylcarbamoyl)-2,3- ...

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Номер записи: 13
03-01-2019 дата публикации

Compound for organic electronic element, organic electronic element using the same, and an electronic device

Номер: US20190006597A1
Автор: LEE Bum Sung, LEE Hak Young, Lee Sun Hee, MUN Soung Yun, PARK Jung Cheol
Принадлежит: DUK SAN NEOLUX CO., LTD.

Provided is an organic electronic element comprising a hole transport layer containing a compound of Formula (1) and an emitting auxiliary layer containing a compound of Formula (2), capable of improving the light emitting efficiency, stability, and life span of an electronic device using the same. 8. An organic electronic element according to claim 1 , wherein all of Arto Arin the formula (2) are aryl groups of Cto C.9. An organic electronic element according to claim 1 , wherein at least one of Arto Arof the Formula (2) is C-Cheteroaryl group.10. An organic electronic element according to claim 2 , wherein the hole transport layer comprises a compound represented Formula (3) and the emitting auxiliary layer comprises a compound represented Formula (2).11. An organic electronic element according to claim 2 , wherein the hole transport layer comprises a compound represented Formula (4) and the emitting auxiliary layer comprises a compound represented Formula (2).12. An organic electronic element according to claim 1 , wherein the emitting auxiliary layer comprises a mixture of two or more compounds represented by the formula (2).13. A display device comprising the organic electronic element of any one of to ; and a control part driving the display apparatus.14. A display device according to claim 13 , wherein the organic electronic element is at least one of an OLED claim 13 , an organic solar cell claim 13 , an organic photo conductor (OPC) claim 13 , Organic transistor (organic TFT) and an element for monochromic or white illumination. The present invention relates to compound for organic electronic element, organic electronic element using the same, and an electronic device thereof.Recently, organic electroluminescence display devices using an emitting material as an emitting element of a display has been actively developed. Unlike a liquid crystal display device or the like, an organic EL display device is a so-called self-luminous type in which realize a ...

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Номер записи: 14
03-01-2019 дата публикации

Organic functional compound for preparing organic electronic device and application thereof

Номер: US20190006609A1
Автор: Junyou Pan, XI Yang
Принадлежит: Guangzhou Chinaray Optoelectronic Materials Ltd

The present invention discloses an organic functional compound for preparing an organic electronic device and an application thereof. The organic functional compound has a general formula (I). The organic functional compound comprises an organic functional group and a solubilizing group, thereby imparting a good solubility and film-forming ability. The organic functional compound also excels in maintaining the performance of the functional group in a device. The organic functional compound and a composition or mixture comprising the organic functional compound have a good printability and film-forming ability, facilitating solution-processing, particularly in printing techniques, and obtaining a high-performance small-molecule organic electronic device, particularly an organic electroluminescent device. FSG] k   (I)

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Номер записи: 15
11-01-2018 дата публикации

THERAPEUTIC COMPOUNDS AND USES THEREOF

Номер: US20180009735A1
Автор: Albrecht Brian K., Audia James Edmund, CÔTÉ Alexandre, Duplessis Martin, Gehling Victor S., Good Andrew Charles, Harmange Jean-Christophe, LEBLANC Yves, Nasveschuk Christopher G., Taylor Alexander M., Vaswani Rishi G.
Принадлежит:

Provided herein are compounds of formula I: 23-. (canceled)4. The compound of claim 1 , wherein X is —CH— claim 1 , —CHCH— or —CHCHCH—.79-. (canceled)11. The compound of claim 1 , wherein X is or —N(R)C(R)—.1214-. (canceled)15. The compound of claim 1 , wherein Ris hydrogen claim 1 , halo claim 1 , heteroaryl claim 1 , —OR claim 1 , CN claim 1 , —C(O)—N(R)or —C(O)—OR claim 1 , wherein any heteroaryl of Ris optionally substituted with one or more Rgroups.1618-. (canceled)2022-. (canceled)2425-. (canceled)27. (canceled)2933-. (canceled)36. (canceled)40. (canceled)42. (canceled)43. A method of treating cancer in an animal comprising administering to the animal in need thereof a compound of formula I or a pharmaceutically acceptable salt thereof as described in .44. A method of treating an LSD1-mediated disorder in an animal comprising administering to the animal in need thereof a compound of formula I or a pharmaceutically acceptable salt thereof as described in .4549-. (canceled)50. A method of increasing efficacy of a cancer treatment comprising a cytotoxic agent in an animal comprising administering to the animal an effective amount of a compound of formula I or a pharmaceutically acceptable salt thereof as described in .51. (canceled)52. A method of delaying or preventing development of cancer resistance to a cytotoxic agent in an animal claim 1 , comprising administering to the animal a compound of formula I or a pharmaceutically acceptable salt thereof as described in .53. A method of extending the duration of response to a cancer therapy in an animal claim 1 , comprising administering to the animal undergoing the cancer therapy a compound of formula I or a pharmaceutically acceptable salt thereof claim 1 , as described in claim 1 , wherein the duration of response to the cancer therapy when the compound of formula I is administered is extended over the duration of response to the cancer therapy in the absence of the administration of the compound of formula I or ...

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Номер записи: 16
11-01-2018 дата публикации

MATERIAS FOR ELECTRONIC DEVICES

Номер: US20180013068A1
Автор: Buesing Arne, Eberle Thomas, Mujica-Fernaud Teresa, Parham Amir Hossain, Pflumm Christof, Stoessel Philipp, Voges Frank
Принадлежит:

The present invention relates to a compound of the formula (I), (II) or (III), to the use of the compound in an electronic device, and to an electronic device comprising a compound of the formula (I), (II) or (III). The present invention furthermore relates to a process for the preparation of a compound of the formula (I), (II) or (III) and to a formulation comprising one or more compounds of the formula (I), (II) or (III). 117-. (canceled)19. The compound of claim 18 , wherein the group Aror claim 18 , in the case where m=0 claim 18 , the group N(Ar) claim 18 , is bonded to the fluorenyl ring system in the 3-position.20. The compound of claim 18 , wherein A is C(R).21. The compound of claim 18 , wherein Arrepresents an aromatic ring system having 6 to 12 aromatic ring atoms claim 18 , optionally substituted by one or more radicals R.22. The compound of claim 18 , wherein Arrepresents a phenylene group claim 18 , optionally substituted by one or more radicals R.23. The compound of claim 18 , wherein m is zero.24. The compound of claim 18 , wherein Z is CRif no group is bonded in the relevant position and wherein Z is C if a group is bonded in the relevant position.25. The compound of claim 18 , wherein n is 1 or 2.26. The compound of claim 18 , with the proviso that no condensed aryl group having more than 14 aromatic ring atoms is present in the compound.27. The compound of claim 18 , wherein the compound cannot be represented by a mirror-symmetrical structural formula.28. The compound of claim 18 , wherein Aris phenyl claim 18 , which may be substituted by one or more radicals R claim 18 , where radicals Ron groups Arcannot form rings.29. The compound of claim 18 , wherein Aris an aromatic ring system having 6 to 30 aromatic ring atoms claim 18 , which may be substituted by one or more radicals R.30. The compound of claim 18 , wherein Ris on each occurrence claim 18 , identically or differently claim 18 , selected from H claim 18 , D claim 18 , F claim 18 , CN ...

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Номер записи: 17
10-01-2019 дата публикации

REDUNDANT POWER LINE CONTROL SYSTEMS

Номер: US20190013470A1
Автор: Bogdanovich Phillip
Принадлежит:

Methods, systems, and apparatus for monitoring and controlling electronic devices using wired and wireless protocols are disclosed. The systems and apparatus may monitor their environment for signals from electronic devices. The systems and apparatus may take and disambiguate the signals that are received from the devices in their environment to identify the devices and associate control signals with the devices. The systems and apparatus may use communication means to send control signals to the identified electronic devices. Multiple apparatuses or systems may be connected together into networks, including mesh networks, to make for a more robust architecture. 1. A system for controlling electronic devices located at a site , comprising: a processor; and', 'a memory coupled to the processor;', 'wherein the control apparatus is configured to couple to at least one conductor in a power line associated with an electronic device receiving power from the power line, and wherein the control apparatus is configured to redirect electrical power from the at least one conductor through the control apparatus and to the electronic device;, 'a plurality of control apparatus, wherein one or more of the control apparatus comprisewherein a first control apparatus and a second control apparatus are configured to establish a communication link to at least one electronic device located at the site, the communication link comprising at least one of a wireless communication link and a power line communication link; andwherein at least one of the first control apparatus and the second control apparatus is configured to monitor and control the at least one electronic device using the established communication link.2. The apparatus of claim 1 , wherein at least one of the first control apparatus and the second control apparatus are configured to establish a wireless communication link with a remote device.3. The apparatus of claim 2 , wherein the control apparatus having the wireless ...

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Номер записи: 18
21-01-2021 дата публикации

APPARATUS FOR COUPLING TO EXISTING POWER LINES

Номер: US20210021303A1
Автор: Bogdanovich Phillip
Принадлежит: Crius Technology Group, Inc.

Methods, systems, and apparatus for monitoring and controlling electronic devices using wired and wireless protocols are disclosed. The systems and apparatus may monitor their environment for signals from electronic devices. The systems and apparatus may take and disambiguate the signals that are received from the devices in their environment to identify the devices and associate control signals with the devices. The systems and apparatus may use communication means to send control signals to the identified electronic devices. Multiple apparatuses or systems may be connected together into networks, including mesh networks, to make for a more robust architecture. 1. A clamp , comprising:a non-conductive blade;a conductive blade, wherein the conductive blade is offset from the non-conductive blade;wherein the non-conductive blade is configured to sever a power line and disrupt power through the power line;wherein the conductive blade is configured to splice into the power line and redirect the power from the power line while also providing the power back to the power line.2. The clamp of claim 1 , wherein the conductive blade is configured to splice into the power line simultaneously with the non-conductive blade.3. The clamp of claim 1 , further comprising an insulated tube claim 1 , wherein a portion of the non-conductive blade and a portion of the conductive blade are positioned in the insulated tube.4. The clamp of claim 3 , further comprising a contact pad claim 3 , wherein a first portion of the contact pad is electrically connected to the conductive blade claim 3 , and wherein a second portion of the contact pad is electrically connected to an electronic device control apparatus.5. The clamp of claim 4 , wherein the contact pad facilitates flow of current from inside of the insulated tube to an area outside of the insulated tube.6. The clamp of claim 1 , wherein the non-conductive blade comprises a piercing surface configured to splice into the power line.7. ...

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Номер записи: 19
28-01-2016 дата публикации

Method and apparatus for performing an energy audit

Номер: US20160025782A1
Автор: Phillip Bogdanovich
Принадлежит: Hyperion Energy Group LLC

Methods and apparatuses for performing an energy audit are disclosed, including using one or more current sensors clamped to an existing lighting system to measure one or more current or voltage signals over a first period of time; calculating a first power usage from the one or more current or voltage signals; replacing the existing lighting system with a replacement lighting system; using the one or more current sensors to measure one or more current or voltage signals of the replacement lighting system over a second period of time; calculating a second power usage from the one or more current or voltage signals; determining a power difference between the first power usage and the second power usage; using the power difference to estimate a cost savings between the first period of time and the second period of time; and generating an energy audit report. Other embodiments are described and claimed.

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Номер записи: 20
17-02-2022 дата публикации

TRICYCLIC SPIRO COMPOUND

Номер: US20220048881A1
Автор: ASADA Masaki, FUCHIBE Kazuhiro, HIGUCHI Satonori, HIROBE Masaya, KOTANI Tohru, Oikawa Ryo, TAKANO Hirotsugu, TANI Kousuke
Принадлежит: ONO PHARMACEUTICAL CO., LTD.

A medicinal agent for the prevention and/or treatment of diseases caused by EPreceptor activation is disclosed. A compound having antagonistic activity against the EPreceptor is contained as an active ingredient in the medicinal agent. The compound represented by the following general formula (I) as defined in the specification, a salt, an N-oxide, or a solvate thereof, or a prodrug of these is useful as a medicinal component having antagonistic activity against the EPreceptor for the prevention and/or treatment of diseases caused by EPreceptor activation. 1. A method for preventing and/or treating a disease caused by EPreceptor activation in a subject in need thereof ,the method comprising administering an effective amount of a compound that is 4-[4-cyano-2-({[(2′R,4S)-6-(isopropylcarbamoyl)-2,3-dihydrospiro[chromene-4,1′-cyclopropan]-2′-yl]carbonyl}amino)phenyl]butanoic acid, a salt thereof, or a solvate thereof, or a prodrug of these to the subject.2. The method according to claim 1 , wherein the disease caused by EPreceptor activation is a bone disease claim 1 , a cancer claim 1 , a systemic granulomatous disease claim 1 , an immune disease claim 1 , alveolar pyorrhea claim 1 , gingivitis claim 1 , periodontitis claim 1 , Kawasaki disease claim 1 , multiple organ failure claim 1 , chronic headache claim 1 , pain claim 1 , vasculitis claim 1 , venous incompetence claim 1 , varicose veins claim 1 , aneurysm claim 1 , aortic aneurysm claim 1 , anal fistula claim 1 , diabetes insipidus claim 1 , patent ductus arteriosus in neonates claim 1 , or cholelithiasis.3. The method according to claim 2 , wherein the cancer is breast cancer claim 2 , ovarian cancer claim 2 , colorectal cancer claim 2 , lung cancer claim 2 , prostate cancer claim 2 , head and neck cancer claim 2 , lymphoma claim 2 , uveal melanoma claim 2 , thymoma claim 2 , mesothelioma claim 2 , esophageal cancer claim 2 , stomach cancer claim 2 , duodenal cancer claim 2 , hepatocellular carcinoma claim 2 , ...

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Номер записи: 21
30-01-2020 дата публикации

PLEUROMUTILIN DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY MICROBES

Номер: US20200030335A1
Автор: Badegruber Rudolf, BULUSU Atchyuta Rama Chandra Murty, Ferencic Mathias, Heilmayer Werner, Mang Rosemarie, Novak Rodger, Strickmann Dirk
Принадлежит:

A compound of formula (I) wherein n is 0 to 4; m is 0 or 1 with the proviso that the sulphur atom and Rare in vicinal position (if m=0 then Ris in position 2′, and if m=1 then Ris on position 1′); R is ethyl or vinyl; Ris hydrogen or (C1-6)alkyl; Ris hydrogen or —(C)cycloalkyl, or —unsubstituted (C)alkyl, or —(C)alkyl substituted by one or more of —hydroxy; preferably one or two, —methoxy, —halogen, —(C)cycloalkyl, or Rand Rtogether with the nitrogen atom to which they are attached form a 5 to 7 membered heterocyclic ring containing at least 1 nitrogen atom or 1 nitrogen and 1 additional heteroatome e.g. selected from N or O, or Ris hydroxy and Ris formyl; Ris OH, OR, a halogen atom, or —with the proviso that Ris bound to 2′ Rrepresents —O—(CH)P—O— with p is 2 or 3; Ris unsubstituted (C)alkyl or (C)cycloalkyl. 8. The compound according to any of to in the form of a salt and/or solvate.9. A compound according to any of to for use as a pharmaceutical drug substance.10. A method of treatment of diseases mediated by microbes which comprises administering to a subject in need of such treatment an effective amount of a compound of any one of to .11. A pharmaceutical drug composition comprising a compound of anyone of to , in association with at least one pharmaceutical excipient.12. A pharmaceutical drug composition according to claim 11 , further comprising another pharmaceutically active agent. The present invention relates to organic compounds, namely pleuromutilins.Pleuromutilin, a compound of formula Ais a naturally occurring antibiotic, e.g. produced by the basidomycetes and , see e.g. The Merck Index, 13th edition, item 7617. A number of further pleuromutilins having the principle ring structure of pleuromutilin and being substituted at the hydroxy group have been developed, e.g. as antimicrobials.From WO 02/04414 A1 pleuromutilin derivatives, e.g. 14-O-[(Aminocyclohexan-2-yl (and -3-yl)-sulfanyl)-acetyl]-mutilins; from WO 07/014409 A1e.g. 14-O-[((Mono- or ...

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Номер записи: 22
01-02-2018 дата публикации

NOVEL COMPOUND FOR ORGANIC ELECTRIC ELEMENT, ORGANIC ELECTRIC ELEMENT USING THE SAME, AND ELECTRONIC DEVICE COMPRISING SAME

Номер: US20180033966A1
Автор: KIM Hyo Jin, KWON Jae Taek, LEE Bum Sung, LEE Hak Young, LEE Mun Jae, Lee Sun Hee, MUN Soung Yun, PARK Jung Cheol, Park Nam Jin
Принадлежит: DUK SAN NEOLUX CO., LTD.

Provided is a novel compound for EBL capable of improving the light emitting efficiency, stability and life span of a device, and an organic electric element and an electronic device using the same. 112.-. (canceled)18. The organic electric element of , wherein the organic material layer comprises a mixture of the compounds of having different structures.19. The organic electric element of claim 18 , further comprising a light efficiency enhancing layer formed on one side of the first electrode opposite to the organic material layer and/or one side of the second electrode opposite to the organic material layer.20. The organic electric element of claim 18 , wherein the organic material layer is formed by a process selected from the group consisting of a spin coating process claim 18 , a nozzle printing process claim 18 , an inkjet printing process claim 18 , a slot coating process claim 18 , a dip coating process claim 18 , and a roll-to-roll process.21. The organic electric element of claim 18 , comprising the compound as a hole transport material.22. The organic electric element comprising: a first electrode; a second electrode; and an organic material layer positioned between the first electrode and the second electrode claim 13 , wherein the organic material layer comprises the compound and wherein the organic material layer comprises a mixture of the compounds having different structures according to .23. An electronic device comprising the display device comprising the organic electric element of ; and a control part driving the display device.24. The electronic device according to claim 23 , wherein the organic electric element is at least one of an OLED claim 23 , an organic solar cell claim 23 , an organic photo conductor (OPC) claim 23 , Organic transistor (organic TFT) and an element for monochromic or white illumination. The present invention relates to compound for organic electric element, organic electric element using the same, and an electronic ...

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Номер записи: 23
18-02-2021 дата публикации

NANOSTRUCTURED FORMULATIONS FOR THE DELIVERY OF SILIBININ AND OTHER ACTIVE INGREDIENTS FOR TREATING OCULAR DISEASES

Номер: US20210046083A1
Автор: "BONDI Maria Luisa", BLANCO Anna Rita, CAVALLARO Gennara, CEIDDA Irene, CONSOLI Grazia Maria Letizia, CRAPARO Emanuela Fabiola, Cuzzocrea Salvatore, ESPOSITO Emanuela, GIAMMONA Gaetano, GRANATA Guiseppe, GUARNERI Patrizia, LA MARCA Clara, LICCIARDI Mariano, PAPASERGI Salvatore, PITARRESI Giovanna, SALADINO Patrizia, VIOLA Santa
Принадлежит:

Formulations are described, containing silibinin or other active ingredients incorporated in lipid nanoparticle systems of the SLN and NLC type, and based on calixarenes, possibly mucoadhesive, or in micellar and nanoparticle systems based on amphiphilic inulin copolymers for use in the treatment of neurodegenerative ocular diseases. The versatility of the calixarene compound is also described, capable of charging and releasing active ingredients characterized by low water solubility, easy chemical and enzymatic degradation, low bioavailability, either of natural origin or not, to be used in the treatment of ocular diseases. 1. A method for the treatment of ocular diseases comprising the topical application of formulations comprising silibinin or sorafenib or curcumin incorporated in calixarene-based nanostructured systems.3. The method of claim 1 , wherein said calixarene-based nanostructured systems have an average diameter in the range between 50 and 200 nm with a polydispersity index below 0.5.4. The method of claim 1 , wherein said systems incorporate an amount in the range between 1 and 15% w/w of silibinin or sorafenib or curcumin.5. The method of claim 1 , wherein said ocular diseases are neurodegenerative ocular diseases.6. The method of claim 5 , wherein said neurodegenerative ocular diseases are selected from: choroidal neovascularization (CNV) claim 5 , age-related macular degeneration (AMD) claim 5 , macular edema claim 5 , neovascular glaucoma claim 5 , macular edema claim 5 , retinopathy of prematurity (ROP) claim 5 , diabetic retinopathy (DR) claim 5 , uveitis claim 5 , endophthalmitis claim 5 , retinitis claim 5 , choroiditis claim 5 , chorioretinitis claim 5 , retinal complications of systemic diseases. This application is a divisional of prior filed U.S. application Ser. No. 15/517,018, filed Apr. 5, 2017, which is the U.S. National Stage of International Application No. PCT/IB2015/057732, filed Oct. 9, 2015, which designated the United States and ...

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Номер записи: 24
18-02-2016 дата публикации

Condensed cyclic compound and organic light-emitting device including the same

Номер: US20160049590A1
Автор: Jinsoo HWANG, Myeongsuk KIM, Seungsoo YOON, Sungwook Kim
Принадлежит: Samsung Display Co Ltd, Sungkyunkwan University Research and Business Foundation

A condensed cyclic compound and an organic light-emitting device, the compound being represented by Formula 1 below:

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Номер записи: 25
15-02-2018 дата публикации

COMPOUND AND ORGANIC ELECTRONIC DEVICE USING THE SAME

Номер: US20180047908A1
Автор: Chen Chi-Chung, LIAO Liang-Di, SHIEH Shwu-Ju, WU Hui-Ling
Принадлежит: NICHEM FINE TECHNOLOGY CO., LTD.

Provided are a novel compound and an organic electronic device using the same. The novel compound is represented by the following Formula (I): 2. The compound as claimed in claim 1 , wherein a1 is an integral of 1 claim 1 , and a2 is an integral of 0.3. The compound as claimed in claim 1 , wherein a1 is an integral of 0 claim 1 , and a2 is an integral of 1.4. The compound as claimed in claim 1 , wherein a1 is an integral of 1 claim 1 , and a2 is an integral of 1.6. The compound as claimed in claim 1 , wherein the heteroaryl groups having 3 to 60 ring carbon atoms of Gand Gare each selected from the group consisting of: a substituted or unsubstituted furyl group claim 1 , a substituted or unsubstituted pyrrolyl group claim 1 , a substituted or unsubstituted thiophenyl group claim 1 , a substituted or unsubstituted imidazolyl group claim 1 , a substituted or unsubstituted pyrazolyl group claim 1 , a substituted or unsubstituted triazolyl group claim 1 , a substituted or unsubstituted tetrazolyl group claim 1 , a substituted or unsubstituted oxazolyl group claim 1 , a substituted or unsubstituted isoxazolyl group claim 1 , a substituted or unsubstituted thiazolyl group claim 1 , a substituted or unsubstituted isothiazolyl group claim 1 , a substituted or unsubstituted oxadiazolyl group claim 1 , a substituted or unsubstituted thiadiazolyl group; a substituted or unsubstituted pyridyl group claim 1 , a substituted or unsubstituted pyridazinyl group claim 1 , a substituted or unsubstituted pyrimidinyl group claim 1 , a substituted or unsubstituted pyrazinyl group claim 1 , a substituted or unsubstituted triazinyl group; a substituted or unsubstituted indolyl group claim 1 , a substituted or unsubstituted isoindolyl group claim 1 , a substituted or unsubstituted benzofuranyl group claim 1 , a substituted or unsubstituted isobenzofuranyl group claim 1 , a substituted or unsubstituted benzothiophenyl group claim 1 , a substituted or unsubstituted isobenzothiophenyl group ...

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Номер записи: 26
15-02-2018 дата публикации

Organic electronic material

Номер: US20180047909A1
Автор: Jinxin Chen, Kam-Hung LOW, Lifei Cai, Zhe Li
Принадлежит: Beijing Aglaia Technology Development Co Ltd, Guangdong Aglaia Optoelectronic Materials Co Ltd

The present invention discloses an “organic electronic material”, belonging to the organic light-emitting device (OLED) display materials field. The organic electronic material in the present invention has a structural formula (I), having good thermal stability, high luminous efficiency, high purity of light emission. The OLED made by this kind of organic light-emitting material has the advantages of excellent organic light-emitting efficiency, excellent color purity and long service life.

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Номер записи: 27
14-02-2019 дата публикации

LIGHT-EMITTING ELEMENT AND DISPLAY DEVICE

Номер: US20190051834A1
Автор: Liu Ying, NIU Jinghua, Shu Peng, Wang Xiangcheng
Принадлежит:

Provided are a light-emitting element and a display device containing the light-emitting element. The light-emitting element comprises an anode, a cathode opposite to the anode, and a plurality of organic layers placed between the anode and the cathode; at least three of the plurality of organic layers each independently contain a compound having a spirobifluorene structure; or at least two of the plurality of organic layers each contain the compound having a spirobifluorene structure and together contain at least three types of the compound having a spirobifluorene structure. By providing the organic layers with the compound having a spirobifluorene structure, the HOMO or LUMO energy level difference for hole or electron transport between different organic layers can be reduced due to the spirobifluorene compounds having the same main ring structure, which facilitates injection of electrons and/or holes, improving the luminous efficiency and lowering the turn on voltage. 1. A light-emitting element , comprisingan anode,a cathode placed opposite to the anode, anda plurality of organic layers placed between the anode and the cathode,wherein at least three of the plurality of organic layers each independently contain a compound having a spirobifluorene structure; orat least two of the plurality of organic layers each contain the compound having a spirobifluorene structure, and the at least two organic layers together contain at least three types of the compound having a spirobifluorene structure.2. The light-emitting element according to claim 1 , whereinthe plurality of organic layers placed between the anode and the cathode comprise a hole transport layer, a light-emitting layer and an electron transport layer; andthe plurality of organic layers placed between the anode and the cathode further comprises any one or more of a hole injection layer, an electron injection layer, an electron blocking layer, and a hole blocking layer;wherein in an instance in which the ...

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Номер записи: 28
14-02-2019 дата публикации

COMPOUND FOR ORGANIC ELECTRONIC ELEMENT, ORGANIC ELECTRONIC ELEMENT USING THE SAME, AND AN ELECTRONIC DEVICE

Номер: US20190051837A1
Автор: LEE Bum Sung, LEE Hak Young, Lee Sun Hee, MUN Soung Yun, PARK Jung Cheol
Принадлежит: DUK SAN NEOLUX CO., LTD.

Provided is an organic electronic element comprising a hole transport layer containing a compound of Formula (3) or (4) and an emitting auxiliary layer containing a compound of Formula (2), capable of improving the light emitting efficiency, stability, and life span of an electronic device using the same. 2. The organic electronic element according to claim 1 , wherein Aris a C-Caryl group claim 1 , Aris a C-Caryl group or a fluorenyl group.3. The organic electronic element according to claim 2 , wherein Aris a fluorenyl group.4. The organic electronic element according to claim 1 , wherein Arand Arare each a substituted or unsubstituted fluorenyl group having different structure from each other.5. The organic electronic element according to claim 4 , wherein Lis a C-Carylene group.6. The organic electronic element according to claim 1 , wherein Aris a C-Caryl group or a fluorenyl group claim 1 , and Aris a C-Cheteroaryl group including at least one heteroatom of O claim 1 , N claim 1 , S claim 1 , Si or P.7. The organic electronic element according to claim 6 , wherein Aris a C-Caryl group.8. The organic electronic element according to claim 6 , wherein Aris a fluorenyl group.9. The organic electronic element according to claim 6 , wherein Aris a dibenzofuranyl group or a dibenzothiophenyl group. This application is a Divisional of U.S. patent application Ser. No. 15/999,002 filed on Aug. 20, 2018, which is a Continuation Application of U.S. patent application Ser. No. 15/507,046, filed Feb. 27, 2017, now U.S. Pat. No. 10,056,560, issued on Aug. 21, 2018, which is a 371 of International Application No. PCT/KR2015/007998 filed on Jul. 30, 2015, which claims the benefit of Korean Patent Application No. 10-2014-0113885, filed Aug. 29, 2014, the contents of which are herein incorporated by reference in their entirety.The present invention relates to compound for organic electronic element, organic electronic element using the same, and an electronic device thereof. ...

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Номер записи: 29
17-03-2022 дата публикации

Nitrogen-containing compound, electronic element and electronic device

Номер: US20220081408A1
Автор: Jiamei CAO, Qiqi NIE, Tiantian MA
Принадлежит: Shaanxi Lighte Optoelectronics Material Co Ltd, Shaanxi Lighte Optoelectronics Materials Co Ltd, SHAANXI LTMS OPTOELECTRONICS MATERIAL CO. LTD., Shaanxi Ltms Optoelectronics Materials Co Ltd

The present disclosure provides a nitrogen-containing compound, an electronic element and an electronic device, which belongs to the technical field of organic materials. The nitrogen-containing compound has a structure of Chemical Formula 1, wherein R1 and R2 are each independently selected from hydrogen or a group represented by Chemical Formula 1-1, and one and only one of R1 and R2 has the group of Chemical Formula 1-1; when R1 or R2 is selected from hydrogen, said R1 and R2 may be replaced by R4. The nitrogen-containing compound can improve the performance of electronic elements.

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Номер записи: 30
28-02-2019 дата публикации

ORTHO-SUBSTITUTED TRIPTYCENE-BASED DIAMINES, MONOMERS, AND POLYMERS, METHODS OF MAKING AND USES THEREOF

Номер: US20190062504A1
Автор: GHANEM Bader Saleh, Ingo Ingo
Принадлежит:

Described herein are ortho-dimethyl-substituted and tetramethyi-substituted triptycene-containing diamine monomers and microporous triptycene-based poiyimides and poiyamides, and methods of making the monomers and polymers. 23-. (canceled)67-. (canceled)8. The structure comprising a polyimide of claim 5 , wherein the structure is a film or membrane in a fluid separation system.912-. (canceled)13. The substituted triptycene-containing diamine of claim 1 , wherein the aromatic moiety comprises an aryl group.14. The substituted triptycene-containing diamine of claim 1 , wherein the aromatic moiety comprises a heteroaryl group.15. The triptycene-based polyimide of claim 4 , wherein the tetravalent radical comprises a C5 to C12 ring.16. The triptycene-based polyimide of claim 4 , wherein the tetravalent radical comprises a multi ring.17. The triptycene-based polyimide of claim 16 , wherein the multi ring comprises an aryl group and a heteroaryl group.18. The composition of claim 5 , wherein the aromatic moiety comprises an aryl group.19. The composition of claim 5 , wherein the aromatic moiety comprises an heteroaryl group. This application claims the benefit of and priority to U.S. Provisional Application Ser. No. 62/238,747, having the title “ORTHO-SUBSTITUTED TRIPTYCENE-BASED DIAMINES, MONOMERS, AND POLYMERS, METHODS OF MAKING AND USES THEREOF,” filed on Oct. 8, 2015, the disclosure of which is incorporated herein in by reference in its entirety.Polyimides are high performance materials that can be used in a range of applications due to their thermal and chemical stability, mechanical robustness, superior film-forming properties, and structural diversity. Recently, polyimides of intrinsic microporosity (PIM-PIs) demonstrated promising properties for membrane-based gas separation applications including air separations (O/N), efficient hydrogen recovery (H/Nand H/CH), natural gas sweetening (CO/CH) and carbon capture from flue gas (CO/N). Gas separation is an emerging ...

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Номер записи: 31
27-02-2020 дата публикации

POLYIMIDE AND POLYIMIDE FILM, PREPARED THEREFROM, FOR FLEXIBLE DISPLAY

Номер: US20200062904A1
Автор: JEONG Hye Won, KIM Kyungjun, KOO Kichul
Принадлежит: LG CHEM, LTD.

Described is a polyimide prepared from a diamine containing a spiro or cardo group in a molecule structure, wherein the dimensional stability of the polyimide can be improved at a high temperature, and thus the polyimide can provide a polyimide film useful for a flexible substrate. 2. The polyimide according to claim 1 , wherein the composition comprises the diamine selected from formulae 1a to 1e in an amount of 30 to 100 mol % based on the total content of the diamine.3. The polyimide according to claim 1 , wherein a coefficient of thermal expansion (CTE) is 50 ppm/° C. or less as measured in the range of 100 to 250° C.4. The polyimide according to claim 1 , wherein a glass transition temperature (Tg) is 330° C. or higher.6. A polyimide film for a flexible display comprising the polyimide of .13. The polyimide according to claim 1 , wherein a molar ratio of a total content of the tetracarboxylic dianyhydride to a total content of the diamine is 1:0.99 to 0.99:1.14. The polyimide according to claim 1 , wherein a weight average molecular weight of the polyimide is 10 claim 1 ,000 to 200 claim 1 ,000 g/mol.15. The polyimide according to claim 1 , wherein a molecular weight distribution of the polyimide is 1.1 to 2.5.16. A method of preparing the polyimide of comprising polymerizing the tetracarboxylic dianhydride with the diamine to form a polymerized product and imidizing the polymerized product. This application claims the benefit of priority to Korean Patent Application Nos. 10-2017-0013726, filed on Jan. 31, 2017 and 10-2017-0167165, filed on Dec. 7, 2017, the entire disclosures of which are incorporated herein by reference.The present invention relates to a polyimide having improved heat resistance and thermal stability, and a polyimide film for a flexible display containing same.Polyimide (PI) is a polymer having a relatively low crystallinity or mostly amorphous structure. It is easy to be synthesized and prepared as a thin film. It is a polymer material ...

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Номер записи: 32
05-06-2014 дата публикации

Fluorene compound and organic electroluminescent device using the same

Номер: US20140151645A1
Автор: Cheng-Hao Chang, Feng-wen Yen, Feng-Ying Wang, Hsu-Kai Chang
Принадлежит: Cheng-Hao Chang, Feng-wen Yen, Feng-Ying Wang, Hsu-Kai Chang

The present invention discloses a new fluorene compound and organic EL device using the compound. The organic EL device employing the new fluorene compound as host material can lower driving voltage, prolong half-lifetime. The fluorene compound can functions as blue emitting host material of a light emitting layer and improve CIE colour purity in blue emitting device. The fluorene compound are represented by the following formula(A): Wherein R 1 to R 6 are identical or different. R 1 to R 6 are independently selected from the group consisting of a hydrogen atom, a halide, alkyl group having 1 to 20 carbon atoms, a substituted or unsubstituted aryl group having 6 to 30 carbon atoms, a substituted or unsubstituted aralkyl group having 6 to 30 carbon atoms, a substituted or unsubstituted heteroaryl group having 6 to 30 carbon atoms. R 7 ˜R 13 are identical or different R 7 to R 13 are independently selected from the group consisting of hydrogen atom, halide, alkyl group, aryl group, heteroaryl group. m and n are independently an integer of 0 to 3, X is selected from carbon or nitrogen.

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Номер записи: 33
22-03-2018 дата публикации

Condensed cyclic compound and organic light-emitting device including the same

Номер: US20180083196A1
Автор: HIROAKI Itoi
Принадлежит: Samsung Display Co Ltd

A condensed cyclic compound and an organic light-emitting device including the same, the condensed cyclic compound being represented by Formula 1:

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Номер записи: 34
29-03-2018 дата публикации

RUNX2 Transcription Factor Inhibitors and Uses Thereof

Номер: US20180086696A1
Автор: Alexander, JR. MacKerell D., Passaniti Antonino
Принадлежит:

Provide herein are compounds with a general chemical structure of: 2. The compound of claim 1 , wherein Ris NH.5. The compound of claim 1 , wherein Rand Rare each Cl and Ris NH.7. A pharmaceutical composition comprising the compound of and a pharmaceutically acceptable carrier.8. A method for treating a cancer in a subject claim 1 , comprising:{'claim-ref': {'@idref': 'CLM-00001', 'claim 1'}, 'administering to the subject a dose of one or more compounds of effective to inhibit a RUNX2 activity, thereby treating the cancer.'}9. The method of claim 8 , further comprising administering one or more other cancer drugs.10. The method of claim 9 , wherein the other cancer drugs are Herceptin claim 9 , Lapatinib claim 9 , or DECMA1 antibody.11. The method of claim 8 , wherein the cancer is breast cancer claim 8 , osteosarcoma claim 8 , ovarian cancer claim 8 , prostate cancer claim 8 , melanoma claim 8 , Ewing sarcoma claim 8 , pancreatic cancer claim 8 , thyroid cancer claim 8 , leukemia claim 8 , head/neck cancer claim 8 , colorectal cancer claim 8 , liver cancer claim 8 , lung claim 8 , pituitary cancer claim 8 , gliomas claim 8 , esophageal cancer claim 8 , or multiple myeloma.12. The method of claim 8 , wherein the cancer is a metastatic cancer.13. A method for inhibiting RUNX2 activity in a cancer cell claim 8 , comprising:{'claim-ref': {'@idref': 'CLM-00001', 'claim 1'}, 'contacting the cancer cell with one or more of the compounds of .'}14. The method of claim 13 , wherein the cancer cell comprises a breast cancer claim 13 , an osteosarcoma claim 13 , an ovarian cancer claim 13 , a prostate cancer claim 13 , a melanoma claim 13 , a Ewing sarcoma claim 13 , a pancreatic cancer claim 13 , a thyroid cancer claim 13 , a leukemia claim 13 , a head/neck cancer claim 13 , a colorectal cancer claim 13 , a liver cancer claim 13 , a lung claim 13 , a pituitary cancer claim 13 , a gliomas claim 13 , an esophageal cancer claim 13 , or a multiple myeloma.15. A method for ...

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Номер записи: 35
19-06-2014 дата публикации

PROCESS FOR MAKING N-SULFINYL a-AMINO AMIDES

Номер: US20140171641A1
Автор: Chris H. Senanayake, Jonathan Timothy Reeves
Принадлежит: BOEHRINGER INGELHEIM INTERNATIONAL GMBH

Disclosed is a process for making diastereomeric N-sulfinyl α-amino amides by reaction of chiral sulfinimines with formamides and lithium diisopropylamide. The process of the invention provides the N-sulfinyl α-amino amides in high yields and with high diastereoselectivity.

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Номер записи: 36
05-04-2018 дата публикации

COMPOUNDS AND ORGANIC ELECTRONIC DEVICES

Номер: US20180097178A1
Автор: Buesing Arne, Montenegro Elvira, Mujica-Fernaud Teresa, Parham Amir Hossain, Voges Frank
Принадлежит:

The present invention relates to certain fluorenes, to the use of the compounds in an electronic device, and to an electronic device comprising at least one of these compounds. The present invention furthermore relates to a process for the preparation of the compounds and to a formulation and composition comprising one or more of the compounds. 122.-. (canceled) The present invention relates to novel organic compounds, to the use of the compounds in an electronic device, and to an electronic device comprising at least one of the compounds. The present invention furthermore relates to a process for the preparation of the compounds and to compositions and formulations comprising at least one of the compounds.The development of functional compounds for use in electronic devices is currently the subject of intensive research. The aim here is, in particular, the development of compounds with which improved properties of electroluminescent devices in one or more relevant points can be achieved, such as, for example, power efficiency, lifetime or colour coordinates of the emitted light.In accordance with the present invention, the term electronic device is taken to mean, inter alia, organic integrated circuits (OICs), organic field-effect transistors (OFETs), organic thin-film transistors (OTFTs), organic light-emitting transistors (OLETs), organic solar cells (OSCs), organic optical detectors, organic photoreceptors, organic field-quench devices (OFQDs), organic light-emitting electrochemical cells (OLECs), organic laser diodes (O-lasers) and organic electroluminescent devices (OLEDs).Of particular interest is the provision of compounds for use in the last-mentioned electronic devices called OLEDs. The general structure and the functional principle of OLEDs are well known to the person skilled in the art and are described, inter alia, in U.S. Pat. No. 4,539,507, U.S. Pat. No. 5,151,629, EP 0676461 and WO 1998/27136.Further improvements are still necessary with respect to ...

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Номер записи: 37
23-04-2015 дата публикации

Organic electronic material

Номер: US20150108448A1
Автор: Jinhai Huang, Jinxin Chen, Lei Dai, Lifei Cai
Принадлежит: Beijing Aglaia Technology Development Co Ltd, Guangdong Aglaia Optoelectronic Materials Co Ltd

The present invention discloses an “organic light-emitting device (OLED)”, comprising an anode, a cathode, and one or more organic layers, wherein the said organic layer contains at least one compound having the formula (I), and the said OLED has the advantages of excellent light-emitting efficiency, excellent color purity and long lifetime.

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Номер записи: 38
12-04-2018 дата публикации

PHENANTHRENE COMPOUNDS FOR ORGANIC ELECTRONIC DEVICES

Номер: US20180102479A1
Автор: Buesing Arne, KROEBER Jonas, Mujica-Fernaud Teresa, Voges Frank
Принадлежит:

The invention relates to specific phenanthrenes, the use of the compound in an electronic device, and an electronic device containing at least one of said compounds. The invention further relates to a method for producing the compound and a formulation and composition containing one or more of the compounds. 117.-. (canceled)24. The compound according to claim 23 , wherein Y is C(R)or NR.25. The compound according to claim 18 , wherein L is a single bond claim 18 , so that the amine group is bonded directly to the phenanthrene.26. The compound according to claim 18 , wherein the compound contains in total at least 26 ring atoms.27. The compound according to claim 18 , wherein the compound contains only one amine group.28. A process for the preparation of the compound according to which comprises a one-step Buchwald coupling by reaction of a phenanthrene derivative which contains a leaving group with Ar—NH—Ar.29. A process for the preparation of the compound according to which comprises a two-step Buchwald coupling by stepwise reaction of a phenanthrene derivative which contains a leaving group with (1) Ar—NHand (2) NH—Ar.30. An oligomer claim 18 , polymer or dendrimer containing one or more compounds according to claim 18 , where the bond(s) to the polymer claim 18 , oligomer or dendrimer is optionally localised at any desired positions in formula (1) which are substituted by R claim 18 , Ror R.31. A composition comprising one or more compound according to and at least one further organically functional material selected from the group consisting of fluorescent emitters claim 18 , phosphorescent emitters claim 18 , host materials claim 18 , matrix materials claim 18 , electron-transport materials claim 18 , electron-injection materials claim 18 , hole-conductor materials claim 18 , hole-injection materials claim 18 , electron-blocking materials and hole-blocking materials.32. A formulation comprising at least one compound according to and at least one solvent.33. An ...

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Номер записи: 39
19-04-2018 дата публикации

Photosensitive resin composition, polyamide resin, method for producing polyamide resin, compound, method for producing compound, method for producing cured film, and cured film

Номер: US20180107114A1
Автор: Dai Shiota, Yoshinori Tadokoro
Принадлежит: Tokyo Ohka Kogyo Co Ltd

A photosensitive resin composition capable of forming a cured film with satisfactory adhesion to substrates and excellent transparency, a polyamide resin which is used in the photosensitive resin composition, a method for producing the polyamide resin, a compound which is used as a raw material of the polyamide resin, a method for producing the compound, a method for producing a cured film using the photosensitive resin composition, and a cured film which is obtained by curing the photosensitive resin composition. The photosensitive resin composition including a resin and a photopolymerization initiator. The resin is a polyamide resin including a structural unit, which includes a specific saturated alicyclic skeleton, and at least one carboxy group esterified by a unit containing a polymerizable group of a predetermined structure.

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Номер записи: 40
02-04-2020 дата публикации

TRICYCLIC SPIRO COMPOUND

Номер: US20200102284A1
Автор: ASADA Masaki, FUCHIBE Kazuhiro, HIGUCHI Satonori, HIROBE Masaya, KOTANI Tohru, Oikawa Ryo, TAKANO Hirotsugu, TANI Kousuke
Принадлежит: ONO PHARMACEUTICAL CO., LTD.

A medicinal agent for the prevention and/or treatment of diseases caused by EPreceptor activation is disclosed. A compound having antagonistic activity against the EPreceptor is contained as an active ingredient in the medicinal agent. The compound represented by the following general formula (I) as defined in the specification, a salt, an N-oxide, or a solvate thereof, or a prodrug of these is useful as a medicinal component having antagonistic activity against the EPreceptor for the prevention and/or treatment of diseases caused by EPreceptor activation. 3. The compound according to claim 1 , or a salt claim 1 , an N-oxide claim 1 , or a solvate thereof claim 1 , or a prodrug thereof claim 1 , wherein at least one Ris —CONHR.4. The compound according to claim 1 , or a salt claim 1 , an N-oxide claim 1 , or a solvate thereof claim 1 , or a prodrug thereof claim 1 , wherein Lis —NHCO— claim 1 , or —CONH—.6. The compound according to claim 1 , which is any one of the following:(1) 4-[4-cyano-2-({[(2′R,4S)-6-(methylcarbamoyl)-2,3-dihydrospiro[chromene-4,1′-cyclopropan]-2′-yl]carbonyl}amino)phenyl]butanoic acid,(2) 4-{4-cyano-2-[({(2′R,4S)-6-[(cyclopropylmethyl)carbamoyl]-2,3-dihydrospiro[chromene-4,1′-cyclopropan]-2′-yl}carbonyl)amino]phenyl}butanoic acid,(3) 4-{4-cyano-2-[({(2′R,4S)-6-[(2-methoxyethyl)carbamoyl]-2,3-dihydrospiro[chromene-4,1′-cyclopropan]-2′-yl}carbonyl)amino]phenyl}butanoic acid,(4) 4-{4-cyano-2-[({(2′R,4S)-6-[(2-methyl-2-propanyl)carbamoyl]-2,3-dihydrospiro[chromene-4,1′-cyclopropan]-2′-yl}carbonyl)amino]phenyl}butanoic acid,(5) 4-[4-cyano-2-({[(2′R,4S)-6-{[(2S)-1-methoxy-2-propanyl]carbamoyl}-2,3-dihydrospiro[chromene-4,1′-cyclopropan]-2′-yl]carbonyl}amino)phenyl]butanoic acid,(6) 4-{4-cyano-2-[({(2′R,4S)-6-[(1-methyl-1H-pyrazol-3-yl)carbamoyl]-2,3-dihydrospiro[chromene-4,1′-cyclopropan]-2′-yl}carbonyl)amino]phenyl}butanoic acid,(7) 4-[4-cyano-2-({[(2′R,4S)-6-(cyclopropylcarbamoyl)-2,3-dihydrospiro[chromene-4,1′-cyclopropan]-2′-yl]carbonyl}amino) ...

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Номер записи: 41
30-04-2015 дата публикации

Process for the preparation of pillar[5]quinone

Номер: US20150119605A1
Автор: Ishwara Shivakumar Kilingaru, Jessy Sanjayan Gangadhar
Принадлежит: Council of Scientific and Industrial Research CSIR

The present invention relates to a process for the preparation of pillar[5]quinone and further relates to an easy-to-operate and chromatography-free process for the preparation of crystalline pillar [5] quinone by the oxone/iodobenzene-mediated oxidative de-aromatization of readily available 1,4-dimethoxypillar[5] arenes in good

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Номер записи: 42
02-04-2020 дата публикации

CONTROLLING ZONES OF ELECTRONIC DEVICES ASSOCIATED WITH POWER LINES

Номер: US20200106479A1
Автор: Bogdanovich Phillip
Принадлежит: Crius Technology Group, LLC

Methods, systems, and apparatus for monitoring and controlling electronic devices using wired and wireless protocols are disclosed. The systems and apparatus may monitor their environment for signals from electronic devices. The systems and apparatus may take and disambiguate the signals that are received from the devices in their environment to identify the devices and associate control signals with the devices. The systems and apparatus may use communication means to send control signals to the identified electronic devices. Multiple apparatuses or systems may be connected together into networks, including mesh networks, to make for a more robust architecture. 1. A system , comprising:a first control apparatus comprising:a memory that stores instructions; determining which control apparatus of a plurality of control apparatuses including the first control apparatus has a strongest communication link with a remote device; and', 'facilitating relaying of data from the plurality of control apparatuses to the remote device through the control apparatus having the strongest communication link., 'a processor that executes the instructions to perform operations, the operations comprising2. The system of claim 1 , wherein the operations further comprise establishing a communication link between the control apparatus having the strongest communication link and at least one other control apparatus of the plurality of control apparatuses.3. The system of claim 1 , wherein the first control apparatus is configured to couple to a conductor in a power line associated with an electronic device receiving power from the power line.4. The system of claim 3 , wherein the operations further comprise redirecting the power from the conductor through the first control apparatus and to the electronic device.5. The system of claim 1 , wherein the operations further comprise determining claim 1 , after a period of time claim 1 , that a different control apparatus of the plurality of ...

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Номер записи: 43
24-07-2014 дата публикации

Materials for electronic devices

Номер: US20140203216A1
Автор: Amir Hossain Parham, Arne Buesing, Christof Pflumm, Frank Voges, Philipp Stoessel, Teresa Mujica-Fernaud, Thomas Elberle
Принадлежит: Merck Patent GmBH

The present invention relates to a compound of the formula (I), (II) or (III), to the use of the compound in an electronic device, and to an electronic device comprising a compound of the formula (I), (II) or (III). The present invention furthermore relates to a process for the preparation of a compound of the formula (I), (II) or (III) and to a formulation comprising one or more compounds of the formula (I), (II) or (III).

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Номер записи: 44
25-08-2022 дата публикации

POLYCYCLIC CARBOGENIC MOLECULES AND USES THEREOF AS ANTI-CANCER AGENTS

Номер: US20220267241A1
Автор: Robinson Emily E., Thomson Regan J.
Принадлежит:

Disclosed are new polycyclic carbogenic molecules and their methods of synthesis. The new polycyclic carbogenic molecules may be utilized in anti-cancer therapies. In particular, the polycyclic carbogenic molecules may be formulated as pharmaceutical compositions that comprise the small molecules, which compositions may be administered in methods of treating and/or preventing cell proliferative diseases and disorders such as cancer. The new polycyclic carbogenic molecules may be prepared from vinyl- or allyl-substituted cyclohexenone precursors via preparation of a silyl bis-enol ether intermediate. 118.-. (canceled)2023.-. (canceled)24. A synthesis method for a polycyclic molecule comprising: (i) first precursor comprising a cyclohexanone substituted at the 5-position or the 6-position with a vinyl group or an allyl group,', '(ii) a second precursor which is a cyclohexanone substituted at the 5-position or the 6-position with a vinyl group or an allyl group, or a second precursor which is an alkyl vinyl ketone; and', '(iii) a dialkyl silyl dihalide to form a symmetrical or unsymmetrical silyl bis-enol ether; and, '(a) reacting a(b) performing oxidative coupling and ring-closing metathesis of the symmetrical or unsymmetrical silyl bis-enol ether to provide the polycyclic molecule.25. The method of claim 19 , wherein m and n are 0.28. The method of claim 27 , wherein m and n are 0.31. The method of claim 30 , wherein m and n are 0.34. The method of claim 33 , wherein m and n are 0. The present application claims the benefit of priority under 35 U.S.C. § 119(e) to U.S. Provisional Application No. 62/561,464, filed on Sep. 21, 2017, the content of which is incorporated herein by reference in its entirety.The field of the invention relates to new small molecules and uses of the new small molecules as anti-cancer agents. The new small molecules are polycyclic carbogenic molecules that are potent to a variety of cancer cells.While treatment options have improved in recent ...

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Номер записи: 45
27-05-2021 дата публикации

AFFINITY ILLUDOFULVENE CONJUGATES

Номер: US20210155583A1
Автор: KELNER Michael
Принадлежит:

In an embodiment of the invention, a composition for treating a cell population comprises a medicant. The medicant moiety can be an illudofulvene analog. In an embodiment of the invention, a composition for treating a cell population comprises an Affinity Medicant Conjugate (AMC). The affinity moiety can be an antibody, an antibody fragment, a receptor protein, a peptidic growth factor, an anti-angiogenic protein, a specific binding peptide, protease cleavable peptide, a glycopeptide, a peptide, a peptidic toxin, a protein toxin and an oligonucleotide. The affinity moiety can be covalently bound to the medicant via a linker. 1. A compound , (a) the compound comprising an illudofulvene moiety , or (b) the compound being an illudofulvene analog , where the illudofulvene moiety or the illudofulvene analog is selected from the group consisting of analog 317 (2'S ,3′R ,6′R)-6′-hydroxy-2′-(hydroxymethyl)-2′ ,4′ ,6′-trimethyl-7′-oxo-2′ ,3′ ,6′ ,7′-tetrahydrospiro[cyclopropane-1 ,5′-inden]-3′-yl 4-(fluorosulfonyl)benzoate; analog 318 ((2'S ,3′R ,6′R)-3′-((4-(fluorosulfonyl)benzoyl)oxy)-6′-hydroxy-2′ ,4′ ,6′-trimethyl-7′-oxo-2′ ,3′ ,6′ ,7′-tetrahydrospiro[cyclopropane-1 ,5′-inden]-2′-yl)methyl 4-(fluorosulfonyl)benzoate; analog 333 ((2'S ,3′R ,6′R)-6′-hydroxy-2′ ,4′ ,6′-trimethyl-3′-(((4-nitrophenoxy)carbonyl)oxy)-7′-oxo-2′ ,3′ ,6′ ,7′-tetrahydrospiro[cyclopropane-1 ,5′-inden]-2′-yl)methyl acetate; analog 334 ((2'S ,3′R ,6′R)-3′-(((2-((tert-butoxycarbonyl)(methyl)amino)ethyl)(methyl)carbamoyl)oxy)-6′-hydroxy-2′ ,4′ ,6′-trimethyl-7′-oxo-2′ ,3′ ,6′ ,7′-tetrahydrospiro[cyclopropane-1 ,5′-inden]-2′-yl)methyl acetate; analog 335 tert-butyl ((2'S ,3′R ,6′R)-6′-hydroxy-2′-(hydroxymethyl)-2′ ,4′ ,6′-trimethyl-7′-oxo-2′ ,3′ ,6′ ,7′-tetrahydrospiro[cyclopropane-1 ,5′-inden]-3′-yl) ethane-1 ,2-diylbis(methylcarbamate); analog 339 ((2'S ,3′R ,6′R)-3′ ,6′-dihydroxy-2′ ,4′ ,6′-trimethyl-7′-oxo-2′ ,3′ ,6′ ,7′-tetrahydrospiro[cyclopropane-1 ,5′-inden]-2′-yl)methyl 4-methylbenzenesulfonate; ...

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Номер записи: 46
02-05-2019 дата публикации

Polycyclic carbogenic molecules and uses thereof as anti-cancer agents

Номер: US20190127306A1
Автор: Emily E. Robinson, Regan James Thomson
Принадлежит: Northwestern University

Disclosed are new polycyclic carbogenic molecules and their methods of synthesis. The new polycyclic carbogenic molecules may be utilized in anti-cancer therapies. In particular, the polycyclic carbogenic molecules may be formulated as pharmaceutical compositions that comprise the small molecules, which compositions may be administered in methods of treating and/or preventing cell proliferative diseases and disorders such as cancer. The new polycyclic carbogenic molecules may be prepared from vinyl- or allyl-substituted cyclohexenone precursors via preparation of a silyl bis-enol ether intermediate.

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Номер записи: 47
03-06-2021 дата публикации

COMPOUND OF 3,3,3',3'-TETRAMETHYL-1,1'-SPIROBIINDANE-BASED PHOSPHINE LIGAND, AND PREPARATION METHOD THEREOF

Номер: US20210163514A1
Автор: CHANG Shirui, Lin Xufeng, Wang Lei, YAO Linxi
Принадлежит:

The present application discloses a 3,3,3′,3′-tetramethyl-1,1′-spirobiindane-based phosphine ligand, an intermediate, a preparation method and uses thereof. The compound of phosphine ligand is a compound having a structure represented by formula I or formula II, or an enantiomer, a raceme, or diastereomer thereof. The phosphine ligand can be prepared via a preparation scheme in which the cheap and easily available 6,6′-dihydroxyl-3,3,3′,3′-tetramethyl-1,1′-spirobiindane is used as a raw material and the compound represented by formula III serves as the key intermediate. The new phosphine ligand developed by the present application can be used in catalytic organic reaction, in particular as a chiral phosphine ligand that is widely used in many asymmetric catalytic reactions including asymmetric hydrogenation and asymmetric allyl alkylation, and thus it has economic practicability and industrial application prospect. 4. The compound represented by formula I or formula II according to claim 1 , wherein Ris selected from the group consisting of phenyl claim 1 , benzyl claim 1 , pentafluorophenyl claim 1 , 4-methylphenyl claim 1 , 4-methoxyphenyl claim 1 , 4-trifluoromethyl-phenyl claim 1 , 3 claim 1 ,5-dimethylphenyl claim 1 , 3 claim 1 ,5-difluorophenyl claim 1 , 3 claim 1 ,5-dimethoxyphenyl claim 1 , 3 claim 1 ,5-di-tert-butylphenyl claim 1 , 3 claim 1 ,4 claim 1 ,5-trimethoxyphenyl claim 1 , 3 claim 1 ,5-dimethyl-4-methoxy-phenyl claim 1 , 3 claim 1 ,5-di-tert-butyl-4-methoxy-phenyl claim 1 , 3 claim 1 ,5-dimethyl-4-methoxy-phenyl claim 1 , and 3 claim 1 ,5-bis(trifluoromethyl)-phenyl.10. A use of the 3 claim 1 ,3 claim 1 ,3′ claim 1 ,3′-tetramethyl-1 claim 1 ,1′-spirobiindane-based phosphine ligand according to claim 1 , wherein the phosphine ligand is complexed with a metal salt of iron claim 1 , osmium claim 1 , gold claim 1 , silver claim 1 , copper claim 1 , platinum claim 1 , rhodium claim 1 , ruthenium claim 1 , iridium claim 1 , nickel claim 1 , molybdenum ...

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Номер записи: 48
02-05-2019 дата публикации

Organic electroluminescent compound and organic electroluminescent device comprising the same

Номер: US20190131526A1
Автор: Hong-Se OH, Young-Kwang Kim
Принадлежит: Rohm and Haas Electronic Materials Korea Ltd

The present disclosure relates to an organic electroluminescent compound and an organic electroluminescent device comprising the same. By using the organic electroluminescent compound of the present disclosure, an organic electroluminescent device having excellent luminous properties can be produced.

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Номер записи: 49
04-06-2015 дата публикации

Inhibitors of beta-secretase

Номер: US20150150872A1
Автор: Angel Morales-Ramos, Cornelia Dorner-Ciossek, Deepak S. Lala, Georg Rast, JING Yuan, Jonathan Reeves, Klaus Fuchs, Lanqi Jia, Lawrence Wayne Dillard, Salvacion Cacatian, Shankar Venkatraman, Suresh B. Singh, Yajun Zheng, Yi Zhao, Yuri Bukhtiyarov, Zhenrong Xu
Принадлежит: BOEHRINGER INGELHEIM INTERNATIONAL GMBH, Vitae Pharmaceuticals LLC

The present invention relates to spirocyclic acylguanidines and their use as inhibitors of the β-secretase enzyme (BACE1) activity, pharmaceutical compositions containing the same, and methods of using the same as therapeutic agents in the treatment of neurodegenerative disorders, disorders characterized by cognitive decline, cognitive impairment, dementia and diseases characterized by production of β-amyloid aggregates.

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Номер записи: 50
24-05-2018 дата публикации

MATERIALS FOR ORGANIC ELECTRLUMINESCENT DEVICES

Номер: US20180145260A1
Автор: Hayer Anna, Heil Holger, Joosten Dominik, MAIER-FLAIG Florian
Принадлежит:

The present invention relates to the fluorene derivatives and to organic electronic devices in which these Compounds are used as matrix material in the emitting layer and/or as hole transport material and/or as electron blocker or exciton blocker material and/or as electron transport material. 115.-. (canceled)17. The compound according to claim 16 , wherein{'sup': 1', '2', '3', '4', '1', '1', '2', '3', '4, 'A, A, A, Ais the same or different at each instance and is CR, with the proviso that not more than two of the A, A, A, Agroups in one cycle are N;'}{'sup': 1', '2', '3', '2', '1', '2', '3, 'V, V, Vis the same or different at each instance and is CR, with the proviso that not more than two of the V, V, Vgroups in one cycle are N;'}{'sup': 1', '2', '3', '3', '1', '2', '3, 'W, W, Wis the same or different at each instance and CR, with the proviso that not more than two of the W, W, Wgroups in one cycle are N;'}{'sup': 1', '2', '3', '4', '1', '2', '3, 'X, X, Xis the same or different at each instance and is CR, with the proviso that not more than two of the X, X, Xgroups in one cycle are N;'}19. The compound according to claim 16 , wherein the compound has a molecular weight of not more than 5000 g/mol.20. The compound according to claim 16 , wherein the compound has a molecular weight of not more than 1000 g/mol.21. The compound according to claim 16 , wherein the compound has a total of not more than 5 nitrogen atoms.22. The compound according to claim 16 , wherein the compound has a total of not more than 3 nitrogen atoms.23. The compound according to claim 16 , wherein the compound has a total of not more than 5 heteroatoms apart from fluorine.24. The compound according to claim 16 , wherein the compound is a hydrocarbon or a fluorinated hydrocarbon.25. The compound according to claim 16 , wherein the compound is a hydrocarbon.26. The compound according to claim 16 , wherein the compound is a wide band gap material.27. The compound according to claim 16 , ...

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Номер записи: 51
02-06-2016 дата публикации

General method for functionalizing carbon nanotubes via solvent free diels-alder reactions

Номер: US20160152477A1
Автор: Shengxiong Xiao, Yan Li
Принадлежит: SHANGHAI PENGXIN ADVANCED MATERIALS TECHNOLOGIES Ltd

The present invention provides methods by which carbon nanotubes can be functionalized via Diels-Alder reactions under solvent free conditions. Such methods include reacting carbon nanotubes with Diels-Alder dienes or dienophiles to obtain adducts that includes the diene or dienophile moiety bound to the carbon nanotubes. Functionalized carbon nanotubes and dispersions containing functionalized carbon nanotubes are provided. The present invention provides functionalization methods of carbon nanotubes through gas phase, liquid phase, or solid phase reactions without any solvents other than the reactants. Such processes are also amenable to a wide variety of chemical reactions that use other functionalizing agents. Additionally, such methods are cost effective, easily scalable and can provide for functionalized CNTs in large, industrial-scale quantities.

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Номер записи: 52
21-08-2014 дата публикации

Spirobifluorene compounds for light emitting devices

Номер: US20140231716A1
Автор: Dominique Bascour, Enrico Orselli, Jonathan Maunoury
Принадлежит: SOLVAY SA

Novel spirobifluorene compounds for light emitting devices where the spirobifluorene ring system comprises at least one ligand in meta-position which is bound to the spirobifluorene through a heteroatom not being part of a ring system.

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Номер записи: 53
15-09-2022 дата публикации

Organic electroluminescent element and electronic device using same

Номер: US20220289704A1
Автор: HIROAKI Itoi, Satomi TASAKI, Taro YAMAKI, Yuki Nakano
Принадлежит: Idemitsu Kosan Co Ltd

An organic electroluminescence device comprising: a cathode, an anode, and an organic layer disposed between the cathode and the anode, wherein the organic layer comprises a compound represented by the following formula (1), and a compound A having a Stokes shift of 20 nm or smaller and an emission peak wavelength of 440 nm to 465 nm (at least one of Ar1 and Ar2 is a monovalent group having a structure represented by the following formula (2)).

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Номер записи: 54
07-06-2018 дата публикации

ARYL ETHERS AND USES THEREOF

Номер: US20180155279A1
Автор: DIXON Darryl David, GRINA Jonas, Josey John A., Rizzi James P., Schlachter Stephen T., Wallace Eli M., Wang Bin, WEHN Paul, Xu Rui, Yang Hanbiao
Принадлежит:

The present disclosure relates to HIF-2α inhibitors and methods of making and using them for treating cancer. Certain compounds were potent in HIF-2α scintillation proximity assay, luciferase assay, and VEGF ELISA assay, and led to tumor size reduction and regression in 786-O xenograft bearing mice in vivo. 164.-. (canceled)66. The method of claim 65 , wherein Ris phenyl or pyridyl claim 65 , wherein said phenyl or pyridyl is substituted with one or more substituents selected from the group consisting of halo claim 65 , C-Calkyl claim 65 , C-Calkoxy and cyano.67. The method of claim 65 , wherein Ris cyano claim 65 , fluoroalkyl claim 65 , sulfinyl claim 65 , sulfonamide claim 65 , sulfonyl or sulfoximinyl.68. The method of claim 65 , wherein Ris hydrogen.69. The method of claim 65 , wherein Ris hydroxy or amino and Ris hydrogen.70. The method of claim 65 , wherein Ris fluoro and n is 1 claim 65 , 2 or 3.73. The method of claim 72 , wherein Ris phenyl or pyridyl claim 72 , wherein said phenyl or pyridyl is substituted with one or more substituents selected from the group consisting of halo claim 72 , C-Calkyl claim 72 , C-Calkoxy and cyano.74. The method of claim 72 , wherein Ris cyano claim 72 , fluoroalkyl claim 72 , sulfinyl claim 72 , sulfonamide claim 72 , sulfonyl or sulfoximinyl.75. The method of claim 72 , wherein Ris hydrogen and Ris hydroxy or amino.76. The method of claim 72 , wherein the enantiomeric excess of said compound is at least about 80%.80. The method of claim 65 , wherein the cancer is hemangioblastoma claim 65 , pheochromocytoma claim 65 , a pancreatic neuroendocrine tumor claim 65 , renal cell carcinoma claim 65 , astrocytoma claim 65 , breast cancer claim 65 , cervical cancer claim 65 , colorectal cancer claim 65 , glioblastoma claim 65 , glioma claim 65 , head and neck cancer claim 65 , hepatocellular cancer claim 65 , non-small cell lung cancer claim 65 , melanoma claim 65 , neuroblastoma claim 65 , ovarian cancer or prostate cancer.81. The ...

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Номер записи: 55
14-05-2020 дата публикации

Compound for organic electric device, organic electric device using same, and electronic device thereof

Номер: US20200152874A1
Автор: Jong Gwang Park, Kyoung Chul KIM, Yeon Hee Choi, Yu Ri Kim, Yun Suk LEE
Принадлежит: DukSan Neolux Co Ltd

Provided in the present invention are a compound capable of improving high luminous efficiency, low driving voltage, and a service life of a device; and organic electric device using the same; and an electronic device thereof.

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Номер записи: 56
15-06-2017 дата публикации

Condensed cyclic compound and organic light-emitting device including the same

Номер: US20170170401A1
Автор: Hyosup Shin, Illsoo Park, Seulong KIM, Sunghun Lee
Принадлежит: Samsung Display Co Ltd

Provided are condensed cyclic compounds and an organic light-emitting device having the compounds which has decreased driving voltage, higher efficiency, and increased overall lifespan.

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Номер записи: 57
01-07-2021 дата публикации

CALIXARENE COMPOUND, CURABLE COMPOSITION, AND CURED PRODUCT

Номер: US20210198178A1
Автор: Imada Tomoyuki, Kadomoto Yutaka, Kai Hidetomo, Miyamoto Masanori, Yamamoto Shinya
Принадлежит:

A calixarene compound represented by formula (1) below is provided. The calixarene compound contains, per molecule, at least one —CHOH group or phenolic hydroxy group and at least one carbon-carbon unsaturated bond. R's are a structural moiety (A), which has a —CHOH group; a structural moiety (B), which has a carbon-carbon unsaturated bond; a structural moiety (C), which has a —CHOH group and a carbon-carbon unsaturated bond; a monovalent organic group (D), which is different from (A), (B), and (C); or a hydrogen atom (E). R's are (A), (B), (C), (D), or (E) provided that not all R's are (E). R's are one of a hydrogen atom, an aliphatic hydrocarbon group, and an aryl group. n is 2 to 10. * is a point of attachment to an aromatic ring. A curable composition including the calixarene compound is provided. A cured product of the curable composition is provided. 18-. (canceled)10. The calixarene compound according to claim 9 , wherein R's in structural formula (1-1) are a group represented by —X—R where X is a direct bond or a carbonyl group claim 9 , and R is a hydrogen atom or a linear alkyl group.12. The calixarene compound according to claim 11 , wherein R's in structural formula (1-2) are a linear alkyl group.13. The calixarene compound according to claim 9 , wherein R's in structural formula (1-1) or (1-2) are a hydrogen atom.16. The calixarene compound according to claim 9 , wherein n is 4.17. A curable composition comprising the calixarene compound according to .18. A cured product of the curable composition according to .19. The calixarene compound according to claim 11 , wherein R's in structural formula (1-1) or (1-2) are a hydrogen atom.22. The calixarene compound according to claim 11 , wherein n is 4.23. A curable composition comprising the calixarene compound according to .24. A cured product of the curable composition according to . The present invention relates to a calixarene compound having a novel structure and relates to a curable composition ...

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Номер записи: 58
01-07-2021 дата публикации

ILLUDIN ANALOGS, USES THEREOF, AND METHODS FOR SYNTHESIZING THE SAME

Номер: US20210198191A1
Автор: Archer Varsin A., BLUMBERG Shawn T., Malakhov Andrey D., Tobin Gregory J.
Принадлежит:

This invention provides illudin derivatives, intermediates, preparation methods, pharmaceutical compositions and uses thereof. Specific examples include novel synthetic routes to prepare illudin derivatives and an illudin derivative having a positive optical rotation, which has therapeutic value. 4. The compound of claim 3 , wherein the compound has a positive optical rotation angle.514.-. (canceled)15. A pharmaceutical composition comprising a compound according to together with a pharmaceutically acceptable carrier.16. (canceled)17. (canceled)19. The compound of claim 3 , wherein R claim 3 , Ror Ris methyl.20. The compound of claim 3 , wherein Ror Ris (C1-C4) alkyl.21. A pharmaceutical composition claim 1 , which comprises a compound as claimed in and a pharmaceutically acceptable carrier.22. A pharmaceutical composition claim 2 , which comprises the mixture as claimed in and a pharmaceutically acceptable carrier This relates to illudin derivatives or analogs, intermediates, preparation methods, pharmaceutical compositions and uses thereof.Illudins are a family of sesquiterpenes with antitumor antibiotic properties and are traditionally produced by various mushrooms. In their isolated form, illudins show selective toxicity for myelocytic leukemia and other malignant cells. species like and (Jack o' Lantern mushrooms), and (Australian ghost fungus) produce the natural forms of Illudins. Illudins are highly toxic and have little therapeutic value in their natural forms.Methods of manufacturing Illudin analogs have generally required the production of Illudin S from liquid growth of an cell culture. (prior art) shows the current semi-synthetic pathway from Illudin S to hydroxymethylacylfulvene (HMAF) and (+) hydroxyureamethylacylfulvene. Although cell lines have been developed that produce a higher ratio of Illudin S to Illudin M, the production of this starting compound has been difficult in terms of expression yields, the time (e.g., >4 weeks of culture) required ...

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Номер записи: 59
21-06-2018 дата публикации

CYCLOPROPANATION OF SUBSTITUTED ALKENES

Номер: US20180170830A1
Автор: BECKER Yigal, GARA Mohamad
Принадлежит:

Disclosed is a cyclopropanation process comprising the step of reacting an alkene compound having at least one carbon-carbon double bond with at least one dihaloalkane. The reaction is carried out in the presence of (i) particulate metal Zn, (ii) catalytically effective amount of particulate metal Cu or a salt thereof, (iii) at least one haloalkylsilane, and (iv) at least one solvent. 1. A cyclopropanation process comprising the step of reacting an alkene compound having at least one carbon-carbon double bond with at least one dihaloalkane in the presence of (i) particulate metal Zn , (ii) catalytically effective amount of particulate metal Cu or a salt thereof , (iii) at least one haloalkylsilane , and (iv) at least one solvent; thereby producing a cyclopropane derivative of said compound.2. A cyclopropanation process according to claim 1 , wherein said alkene compound has at least two carbon-carbon double bonds.3. A cyclopropanation process according to claim 1 , wherein said at least one dihaloalkane is dibromomethane claim 1 , chlorobromomethane claim 1 , or a combination thereof.4. A cyclopropanation process according to claim 1 , wherein said particulate metal Zn has particle size of less than 10 μm.5. A cyclopropanation process according to claim 1 , wherein said particulate metal Cu has particle size of less than 50 μm.6. A cyclopropanation process according to claim 1 , wherein said haloalkylsilane is chlorotrialkyl silane.7. A cyclopropanation process according to claim 6 , wherein said chlorotrialkyl silane is selected from the group consisting of chlorotrimethylsilane claim 6 , chlorotriethylsilane claim 6 , chlorotributylsilane claim 6 , chlorotriisobutylsilane claim 6 , chlorotrihexylsilane claim 6 , and any combinations thereof.8. A cyclopropanation process according to claim 1 , wherein said at least one solvent is an ether solvent.9. A cyclopropanation process according to claim 8 , wherein said at least one ether solvent is selected from the group ...

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Номер записи: 60
01-07-2021 дата публикации

ORGANIC LIGHT-EMITTING DEVICE AND APPARATUS INCLUDING THE SAME

Номер: US20210202844A1
Автор: CHU Seungjin, Hur Jaeweon, Jeong Hyein, KIM Kyungsik, Kim Seulong, KIM Sungwook
Принадлежит:

An organic light-emitting device in which a hole transport region includes a first hole transport stack, a second hole transport stack between the first hole transport stack and an emission layer, and an electron blocking layer between the second hole transport stack and the emission layer, wherein a HOMO energy level of the hole transport region satisfies a certain equations. The organic light-emitting devices according to embodiments of the present disclosure may have high efficiency and a long lifespan. 1. An organic light-emitting device comprising:a first electrode;a second electrode facing the first electrode; andan organic layer between the first electrode and the second electrode, the organic layer comprising an emission layer and a hole transport region between the first electrode and the emission layer,wherein the hole transport region comprises a first hole transport stack, a second hole transport stack between the first hole transport stack and the emission layer, and an electron blocking layer between the second hole transport stack and the emission layer,the first hole transport stack comprises a first hole injection layer and a first hole transport layer,the second hole transport stack comprises a second hole injection layer and a second hole transport layer,the first hole injection layer is between the first electrode and the first hole transport layer,the second hole injection layer is between the first hole transport layer and the second hole transport layer,the first hole injection layer comprises a first compound,the first hole transport layer comprises a second compound,the second hole injection layer comprises a third compound,the second hole transport layer comprises a fourth compound,the electron blocking layer comprises a fifth compound, and [{'br': None, 'HOMO(HTM1)≥HOMO(HTM2)\u2003\u2003Equation 1'}, {'br': None, 'HOMO(HTM3)≥HOMO(HTM4)\u2003\u2003Equation 2'}, {'br': None, 'HOMO(HTM1)−HOMO(HTM2)≤0.5 eV\u2003\u2003Equation 3'}, {'br': None, ...

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Номер записи: 61
23-06-2016 дата публикации

Anthracene derivative and organic electroluminescent element using same

Номер: US20160181542A1
Автор: Hirokatsu Ito, Masahiro Kawamura, Tasuku Haketa, Tomoharu HAYAMA, Yumiko Mizuki
Принадлежит: Idemitsu Kosan Co Ltd

An anthracene derivative is represented by the following formula (1). In the formula (1), one of R 11 to R 20 is used to bond to L 1 , and is a single bond. The remainder of R 11 to R 20 that are not used to bond to L 1 are independently a hydrogen atom, a halogen atom, a cyano group, a substituted or unsubstituted alkyl group including 1 to 20 carbon atoms, or the like. L 1 is a single bond, a substituted or unsubstituted divalent aromatic hydrocarbon group including 6 to 50 ring carbon atoms, or the like. Z has a structure represented by the following formula (2). In the formula (2), one of R 1 , R 3 , and R 4 is used to bond to L 1 , and is a single bond. The remainder of R 1 , R 3 , and R 4 that are not used to bond to L 1 , R 2 , and R 5 to R 10 are independently a hydrogen atom, a halogen atom, a cyano group, a substituted or unsubstituted alkyl group including 1 to 20 carbon atoms, or the like. At least one pair of groups among R 5 to R 8 that are adjacent to each other are bonded to each other to form a saturated or unsaturated hydrocarbon ring.

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Номер записи: 62
21-06-2018 дата публикации

SPIROFLUORENE DERIVATIVE, MATERIAL FOR LIGHT-EMITTING ELEMENT, LIGHT-EMITTING ELEMENT, LIGHT-EMITTING DEVICE, AND ELECTRONIC DEVICE

Номер: US20180175295A1
Автор: KAWAKAMI Sachiko, Nakashima Harue
Принадлежит:

It is an object of the present invention to provide a material having a high Tg and a wide energy gap. The present invention provides a spirofluorene derivative represented by General Formula 1. (In the formula, Ris any one of hydrogen, an alkyl group having 1 to 4 carbon atoms, or a group represented by General Formula 2. Each of Rand Ris either hydrogen or an alkyl group having 1 to 4 carbon atoms and may be identical or different. Ris an aryl group having 6 to 15 carbon atoms. Each of Rand Ris any one of hydrogen, an alkyl group having 1 to 4 carbon atoms, or an aryl group having 6 to 15 carbon atoms and may be identical or different.) 1. (canceled)7. A light-emitting element containing the spirofluorene derivative according to a .8. The light-emitting element according to claim 7 , wherein the spirofluorene derivative is contained in a hole transporting layer of the light emitting element.9. The light-emitting element according to claim 7 , wherein the spirofluorene derivative is contained in a hole injecting layer of the light emitting element.10. The light-emitting element according to claim 7 , wherein the spirofluorene derivative is contained in a light emitting layer of the light emitting element as a host material.11. A light-emitting device comprising:{'claim-ref': {'@idref': 'CLM-00007', 'claim 7'}, 'the light-emitting element according to ; and'}a control circuit which controls light emission of the light-emitting element.12. An electronic device comprising:{'claim-ref': {'@idref': 'CLM-00007', 'claim 7'}, 'a display portion using the light-emitting element according to ; and'}a control circuit which controls light emission of the light-emitting element. The present invention relates to a novel material. In particular, the present invention relates to a material which is ideal for use in a light-emitting element in which an organic compound is used in at least one part. In addition, the present invention relates to a light-emitting element, a light- ...

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Номер записи: 63
13-06-2019 дата публикации

PLEUROMUTILIN DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY MICROBES

Номер: US20190175603A1
Автор: Badegruber Rudolf, BULUSU Atchyuta Rama Chandra Murty, Ferencic Mathias, Heilmayer Werner, Mang Rosemarie, Novak Rodger, Strickmann Dirk
Принадлежит:

Pleuromutilin derivative compounds of the following formula (I), and uses thereof for the treatment of diseases mediated by microbes, are disclosed: 7. A compound according to one of the to , selected from the group consisting of14-O-{[(1S, 2S, 4S)-4-Amino-2-hydroxy-cyclohexylsulfanyl]-acetyl}-mutilin14-O-{[(1R, 2R, 5S)-5-Amino-2-hydroxy-cyclohexylsulfanyl]-acetyl}-mutilin14-O-{[(1S, 2S, 5R)-5-Amino-2-hydroxy-cyclohexylsulfanyl]-acetyl}-mutilin14-O-{[(1R, 2R, 4S)-4-Amino-2-hydroxy-cyclohexylsulfanyl]-acetyl}-mutilin and the (1S, 2S, 4R) diastereomer thereof14-O-{[(1R, 2R, 5R)-5-Amino-2-hydroxy-cyclohexylsulfanyl]-acetyl}-mutilin14-O-{[(1S, 2S, 5S)-5-Amino-2-hydroxy-cyclohexylsulfanyl]-acetyl}-mutilin14-O-{[(1R, 2R, 3R)-3-Amino-2-hydroxy-cyclohexylsulfanyl]-acetyl}-mutilin and the (1S, 2S, 3S) diastereomer thereof14-O-{[(1R, 2R, 4R)-4-Diethylamino-2-hydroxy-cyclohexylsulfanyl]-acetyl}-mutilin and the (1S, 2S, 4S) diastereomer thereof14-O-{[(1R, 2R, 4R)-4-Ethylamino-2-hydroxy-cyclohexylsulfanyl]-acetyl}-mutilin and the (1S, 2S, 4S) diastereomer thereof14-O-{[(1R, 2R, 5S)-5-Ethylamino-2-hydroxy-cyclohexylsulfanyl]-acetyl}-mutilin and the (1S, 2S, 5R) diastereomer thereof14-O-{[(1R, 2R, 5S)-5-Diethylamino-2-hydroxy-cyclohexylsulfanyl]-acetyl}-mutilin and the (1S, 2S, 5R) diastereomer thereof14-O-{[(1R, 2R, 4S)-4-Diethylamino-2-hydroxy-cyclohexylsulfanyl]-acetyl}-mutilin and the (1S, 2S, 4R) diastereomer thereof14-O-{[(1R, 2R, 5R)-5-Diethylamino-2-hydroxy-cyclohexylsulfanyl]-acetyl}-mutilin and the (1S, 2S, 5S) diastereomer thereof14-O-{[(1R, 2R, 3R)-3-Ethylamino-2-hydroxy-cyclohexylsulfanyl]-acetyl}-mutilin and the (1S, 2S, 3S) diastereomer thereof14-O-{[(1R, 2R, 3R)-3-Diethylamino-2-hydroxy-cyclohexylsulfanyl]-acetyl}-mutilin and the (1S, 2S, 3S) diastereomer thereof14-O-{[(1R, 2R, 4S)-4-(Formyl-hydroxy-amino)-2-hydroxy-cyclohexylsulfanyl]-acetyl}-mutilin and the (1S, 2S, 4R) diastereomer thereof14-O-{[(1R, 2R, 5S)-5-(Formyl-hydroxy-amino)-2-hydroxy-cyclohexylsulfanyl ...

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Номер записи: 64
13-06-2019 дата публикации

Cyclopropanation of substituted alkenes

Номер: US20190177247A1
Автор: Mohamad GARA, Yigal Becker
Принадлежит: International Flavors and Fragrances Inc

Disclosed is a cyclopropanation process comprising the step of reacting an alkene compound having at least one carbon-carbon double bond with at least one dihaloalkane. The reaction is carried out in the presence of (i) particulate metal Zn, (ii) catalytically effective amount of particulate metal Cu or a salt thereof, (iii) at least one haloalkylsilane, and (iv) at least one solvent.

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Номер записи: 65
13-06-2019 дата публикации

POLYMERIZABLE TRIPTYCENE DERIVATIVE COMPOUND

Номер: US20190177263A1
Автор: YAMAZAKI Yoshiko
Принадлежит: SEED CO., LTD.

It is an objective of the present invention to provide a novel polymerizable triptycene derivative that has a structure in which three benzene rings arranged at the axis formed by barrelene of the triptycene skeleton can rotate evenly and that has hydrophilicity imparted to it as compared to any of the prior art triptycene derivatives and is thus highly useful in functional materials. 2. The polymerizable triptycene derivative according to claim 1 , wherein said unsaturated polymerizable functional group is an unsaturated polymerizable functional group selected from the group consisting of vinyl group and (meth)acryl group. The present application claims the benefit of priority to Japanese Patent Application No. 2016-152953, filed Aug. 3, 2016, the disclosure of which is incorporated herein by reference in its entirety.The present invention relates to a triptycene derivative having a substituted triptycene structure.A polymer compound can be obtained by polymerization of one or combination of two or more of polymerizable compounds such as (meth)acrylic acids and their derivatives as monomer components or by polycondensation of compounds having a dicarboxylic acid or compounds having an amino group and a carboxylic group within the molecules.The characteristics of the polymer compound can vary widely depending on the monomer compounds used as constituent materials or their combinations. Hence, it is necessary to take into consideration such combinations of monomer compounds used as constituent materials or provision of novel monomer compounds for use as constituent materials in order to obtain polymer compounds having new characteristics or polymer compounds having some of their known characteristics improved. To provide novel monomer compounds, known compounds may be chemically modified at specific sites or polymerizable functional groups may be added.Triptycene is an aromatic hydrocarbon having a paddle wheel-like structure in which three benzene rings are arranged ...

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Номер записи: 66
08-07-2021 дата публикации

Compound having triarylamine structure and organic electroluminescence device

Номер: US20210210693A1
Автор: Kouki Kase, Kyung-Hwa Park, Takuya Uehara, Yuta Hirayama
Принадлежит: Hodogaya Chemical Co Ltd

An object of the present invention is to provide an organic compound that has excellent properties, with excellent hole injection and transport performance, electron blocking capability, and high stability in a thin film state, and furthermore to provide a highly efficient and highly durable organic EL device by using this compound. The present invention relates to a compound having a triarylamine structure and being represented by the structural formula (A-1) below, where A, B, and C may be the same or different, and each represent a group represented by the structural formula (B-1) below, a substituted or unsubstituted aromatic hydrocarbon group, a substituted or unsubstituted aromatic heterocyclic group, or a substituted or unsubstituted fused polycyclic aromatic group, where at least one of A, B, and C is not the group represented by the structural formula (B-1) below. (For the symbols and the like in the formulae, see the descriptions in the specification.)

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Номер записи: 67
30-06-2016 дата публикации

Materials for organic electroluminescent devices

Номер: US20160190447A1
Автор: Amir Hossain Parham, Arne Buesing, Christof Pflumm, Constanze Brocke, Elvira Montenegro, Frank Voges, Holger Heil
Принадлежит: Merck Patent GmBH

The present invention relates to compounds of the formula (1) which are suitable for use in electronic devices, in particular organic electroluminescent devices, and to electronic devices which comprise these compounds.

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Номер записи: 68
06-07-2017 дата публикации

O-hydroxy-functionalized diamines, polyimides, methods of making each, and methods of use

Номер: US20170190842A1
Автор: Bader S. Ghanem, Ingo Pinnau, Xiaohua Ma
Принадлежит: King Abdullah University of Science and Technology KAUST

Embodiments of the present disclosure provide for an ortho (o)-hydroxy-functionalized diamine, a method of making an o-hydroxy-functionalized diamine, an o-hydroxy-functionalized diamine-based polyimide, a method of making an o-hydroxy-functionalized diamine imide, methods of gas separation, and the like.

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Номер записи: 69
13-07-2017 дата публикации

Inhibitors of beta-secretase

Номер: US20170196867A1
Автор: Angel Morales-Ramos, Cornelia Dorner-Ciossek, Deepak S. Lala, Georg Rast, JING Yuan, Jonathan Reeves, Klaus Fuchs, Lanqi Jia, Lawrence Wayne Dillard, Salvacion Cacatian, Shankar Venkatraman, Suresh B. Singh, Yajun Zheng, Yi Zhao, Yuri Bukhtiyarov, Zhenrong Xu
Принадлежит: Vitae Pharmaceuticals LLC

The present invention relates to spirocyclic acylguanidines and their use as inhibitors of the β-secretase enzyme (BACE1) activity, pharmaceutical compositions containing the same, and methods of using the same as therapeutic agents in the treatment of neurodegenerative disorders, disorders characterized by cognitive decline, cognitive impairment, dementia and diseases characterized by production of β-amyloid aggregates.

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Номер записи: 70
18-06-2020 дата публикации

REDUNDANT POWER LINE CONTROL SYSTEMS

Номер: US20200194672A9
Автор: Bogdanovich Phillip
Принадлежит:

Methods, systems, and apparatus for monitoring and controlling electronic devices using wired and wireless protocols are disclosed. The systems and apparatus may monitor their environment for signals from electronic devices. The systems and apparatus may take and disambiguate the signals that are received from the devices in their environment to identify the devices and associate control signals with the devices. The systems and apparatus may use communication means to send control signals to the identified electronic devices. Multiple apparatuses or systems may be connected together into networks, including mesh networks, to make for a more robust architecture. 1. A system for controlling electronic devices located at a site , comprising: a processor; and', 'a memory coupled to the processor;', 'wherein the control apparatus is configured to couple to at least one conductor in a power line associated with an electronic device receiving power from the power line, and wherein the control apparatus is configured to redirect electrical power from the at least one conductor through the control apparatus and to the electronic device;, 'a plurality of control apparatus, wherein one or more of the control apparatus comprisewherein a first control apparatus and a second control apparatus are configured to establish a communication link to at least one electronic device located at the site, the communication link comprising at least one of a wireless communication link and a power line communication link; andwherein at least one of the first control apparatus and the second control apparatus is configured to monitor and control the at least one electronic device using the established communication link.2. The apparatus of claim 1 , wherein at least one of the first control apparatus and the second control apparatus are configured to establish a wireless communication link with a remote device.3. The apparatus of claim 2 , wherein the control apparatus having the wireless ...

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Номер записи: 71
27-07-2017 дата публикации

PREPARATION AND BIOLOGICAL EVALUATION OF VIRIDICATUMTOXIN ANALOGS

Номер: US20170210699A1
Автор: EL MARROUNI Abdellatif, HALE Christopher R.H., IOANNIDOU Heraklidia, NICOLAOU Kyriacos C, NILEWSKI Christian
Принадлежит: William Marsh Rice University

In one aspect, the present invention provides novel derivatives of viridicatumtoxin of the formula wherein the variables are as defined herein. The application also provides compositions, methods of treatment, and methods of synthesis thereof. 12. The compound according to any one of - , wherein Ris alkoxyor substituted alkoxy.13. The compound of claim 12 , wherein Ris alkoxy.14. The compound of either or claim 12 , wherein Ris methoxy.15. The compound according to any one of - claim 12 , wherein Ris oxo.16. The compound according to any one of - claim 12 , wherein Ris hydrogen.17. The compound according to any one of - claim 12 , wherein Ris halo.18. The compound of claim 17 , wherein Ris fluoro claim 17 , chloro claim 17 , bromo claim 17 , or iodo.19. The compound according to any one of - claim 17 , wherein Ris hydroxy.20. The compound according to any one of - claim 17 , wherein Ris amino.21. The compound according to any one of - claim 17 , wherein Ris dialkylaminoor substituted dialkylamino.22. The compound of claim 21 , wherein Ris dialkylamino.23. The compound of either or claim 21 , wherein Ris dimethylamino or (2-aminoethyl)methylamino.24. The compound according to any one of - claim 21 , wherein Ris hydrogen.25. The compound according to any one of - claim 21 , wherein Ris hydrogen.26. The compound according to any one of - claim 21 , wherein Ris alkanediyl-heterocycloalkyl.27. The compound of claim 26 , wherein Ris CHCHN(CH).28. The compound according to any one of - claim 26 , wherein Ris alkanediyl-alkylamino.29. The compound of claim 28 , wherein Ris (CH)NH(CH)CH(NH)COH.30. The compound according to any one of - claim 28 , wherein Ris hydrogen.31. The compound according to any one of - claim 28 , wherein Ris —X—R.32. The compound of claim 31 , wherein Xis alkanediylor substituted alkanediyl.33. The compound of either or claim 31 , wherein Xis alkanediyl.34. The compound according to any one of - claim 31 , wherein Xis —CHCHCH— or —CHCH—.35. The ...

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Номер записи: 72
27-07-2017 дата публикации

Novel compound and organic electronic device comprising the same

Номер: US20170213970A1
Автор: Chi-Chung Chen, Liang-Di LIAO, Shwu-Ju Shieh
Принадлежит: Nichem Fine Technology Co Ltd

A novel compound is disclosed, which is represented by the following Formula (I): wherein Ar 1 , Ar 2 , Ar 3 , Ar 4 , L, Q, G, n1, n2, m1, m2 and q represent the same as defined in the specification. In addition, an organic electronic device is also disclosed, and an organic layer therein comprises the novel compound of the present invention.

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Номер записи: 73
27-07-2017 дата публикации

Compound and electronic device including same

Номер: US20170213990A1
Автор: Chi-Chung Chen, Shwu-Ju Shieh
Принадлежит: Nichem Fine Technology Co Ltd

A compound is disclosed. The compound has a formula of MA x L y , wherein: A is L is one of M is a metal having six valence electrons, x is an integer from 1-3, y is an integer from 0-2, x+y=3, any of R a -R b and R 1 -R 3 is independently selected from a group consisting of hydrogen, deuterium, fluorine, chlorine, bromine, iodine, N(R 1 ) 2 , N(Ar 1 ) 2 , C(═O)Ar 2 , P(═O)Ar 3 2 , S(═O)Ar 4 , S(═O) 2 Ar 5 , CR 2 ═CR 3 Ar 6 , CN, NO 2 , Si(R 4 ) 3 , B(OR 5 ) 2 , OSO 2 R 6 , a linear alkyl having 1 to 40 carbon atoms, a C 1 -C 40 alkoxyl, a C 1 -C 40 alkylthiol, a C 3 -C 40 branched alkyl, a C 3 -C 40 cycloalkyl, a C 3 -C 40 branched alkoxyl, a C 3 -C 40 cyclic alkoxyl, a C 3 -C 40 branched alkylthiol and a C 3 -C 40 cyclic alkylthiol, any of R 1 -R 6 is one of a hydrogen and an alkyl, any of Ar 1 -Ar 6 is one of a hydrogen and an aryl, and any of R 4 ˜R 11 and R 13 ˜R 15 is independently selected from a group consisting of a hydrogen, a deuterium, a halogen, a substituted or unsubstituted alkyl, a substituted or unsubstituted cycloalkyl and a substituted or unsubstituted aryl.

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Номер записи: 74
05-08-2021 дата публикации

Calixarene Indicator

Номер: US20210239622A1
Автор: Spiel Paul D
Принадлежит:

A pyrogallarene solution and a method for using a calixarene as an indicator are disclosed. The calixarene may be a pyrogallarene, and the pyrogallarene may be a pyrogallol[4]arene. The pyroallol[4]arene may be C-alkyl pyrogallol[4]arene. The calixarene indicator having a dynamic chromophore may be used to assess pH, metal content, or water content. 1. A method of: using the chromophore of a calixarene as an indicator.2. The method of claim 1 , wherein the calixarene is used as a visual indicator.3. The method of claim 2 , wherein the calixarene is used as a visual indicator for pH.4. The method of claim 1 , wherein the calixarene is measured radiometrically.5. The method of claim 1 , wherein the calixarene is measured photometrically.6. The method of claim 2 , wherein the calixarene is a resorcinarene.7. The method of claim 2 , wherein the calixarene is a pyrogallarene.8. The method of claim 7 , wherein the pyrogallarene is a pyrogallol[4]arene.9. The method of claim 8 , wherein the pyrogallol[4]arene is used to assess water content.10. The method of claim 8 , wherein the pyrogallol[4]arene is used in a solid phase.11. The method of claim 8 , wherein the pyrogallol[4]arene is used to assess metal content.12. The method of claim 8 , wherein the pyrogallol[4]arene is used to assess pH.13. The method of claim 12 , wherein the pyrogallol[4]arene changes color in the range of about pH 4 to 7.14. The method of claim 12 , wherein the pyrogallol[4]arene is dissolved in at least one solution.15. The method of claim 12 , wherein the at least one solution is one of DMF claim 12 , DMSO claim 12 , Acetone claim 12 , Methanol claim 12 , Ethanol claim 12 , or water.16. A method of using the chromophore of a pyrogallol[4]arene as an indicator comprising:dissolving the pyrogallol[4]arene in at least one solution; andoptically observing the color of the at least one solution.1720-. (canceled) This application claims priority to U.S. provisional patent application 62/681,542 filed 6 ...

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Номер записи: 75
16-10-2014 дата публикации

Organic compound and organic light emitting diode device including the same

Номер: US20140306190A1
Автор: Eun-Jae Jeong, Eun-young Lee, Hye-jin Jung, Jin-O Lim, Jong-hyuk Lee, Jun-Ha Park, Sang-hyun Han, Seok-Hwan Hwang, Soo-Yon Kim, Young-Kook Kim
Принадлежит: Samsung Display Co Ltd

Disclosed are a novel organic compound and an organic light emitting diode device using the same. More particularly, a novel organic compound having electrical stability, high charge transport capability, and light emitting performance, high glass transition temperature and being capable of preventing crystallization, and an organic light emitting diode device including an organic layer including the same are disclosed.

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Номер записи: 76
13-08-2015 дата публикации

Method for manufacturing olefin derivative

Номер: US20150225331A1
Автор: Akira Shiibashi, Daisuke Watanabe, Shin-ichi Komatsu, Takaya Matsumoto
Принадлежит: JX Nippon Oil and Energy Corp

There is provided a method for manufacturing an olefin derivative which is capable of improving the yield and manufacturing efficiency. The method for manufacturing an olefin derivative according to the present invention comprises a first step of reacting an olefin with an alcohol and carbon monoxide in the presence of a palladium catalyst and an oxidizing agent in a reactor to thereby synthesize a carboxylic acid or a carboxylate ester, a second step of discharging at least part of a gas in the reactor out of the reactor, and separating carbon monoxide from the gas discharged during the first step; and a third step of supplying the carbon monoxide separated from the gas in the second step to the reactor during the first step.

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Номер записи: 77
03-08-2017 дата публикации

NANOSTRUCTURED FORMULATIONS FOR THE DELIVERY OF SILIBININ AND OTHER ACTIVE INGREDIENTS FOR TREATING OCULAR DISEASES

Номер: US20170216309A1
Автор: BLANCO Anna Rita, Bondi Maria Luisa, CAVALLARO Gennara
Принадлежит:

Formulations are described, containing silibinin or other active ingredients incorporated in lipid nanoparticle systems of the SLN and NLC type, and based on calixarenes, possibly mucoadhesive, or in micellar and nanoparticle systems based on amphiphilic inulin copolymers for use in the treatment of neurodegenerative ocular diseases. The versatility of the calixarene compound is also described, capable of charging and releasing active ingredients characterized by low water solubility, easy chemical and enzymatic degradation, low bioavailability, either of natural origin or not, to be used in the treatment of ocular diseases. 18-. (canceled)10. Formulations according to claim 9 , wherein said ocular diseases are neurodegenerative ocular diseases.11. Formulations according to claim 9 , wherein said lipid nanoparticle systems consist of lipids selected from: triglycerides claim 9 , diglycerides claim 9 , monoglycerides claim 9 , aliphatic alcohols claim 9 , fatty acids (C10-C22); fatty acid esters with fatty alcohols claim 9 , mixtures of mono- claim 9 , di- and triglycerides of pegylated behenic acid claim 9 , mono- claim 9 , di- and triglycerides of pegylated captylic and caproic acids.12. Formulations according to claim 9 , wherein said mucoadhesives are selected from:inulin polymers bearing amino groups, low molecular weight polymers and cationic surfactants.13. Formulations according to claim 9 , wherein said nanoparticle systems have an average diameter in the range between 50 and 200 nm with a polydispersity index below 0.5.14. Formulations according to claim 11 , wherein said systems incorporate an amount of active ingredient selected from: silibinin claim 11 , sorafenib claim 11 , curcumin claim 11 , latanoprost in the range between 1 and 15% w/w.15. Formulations according to claim 9 , wherein said neurodegenerative ocular diseases are selected from: choroidal neovascularization (CNV) claim 9 , age-related macular degeneration (AMD) claim 9 , macular edema ...

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Номер записи: 78
05-08-2021 дата публикации

Rechargeable Aluminum Organic Batteries

Номер: US20210242452A1
Автор: CHOI Jang Wook, KIM Dong Jun, Stoddart James Fraser, Yoo Dong-Joo
Принадлежит:

Disclosed herein are rechargeable aluminum organic batteries and active materials used therein. The cathodic materials used herein comprise a macrocycle comprising a substituted or unsubstituted phenanthrenequinone unit and a graphite flake. 1. A cathodic material comprising a macrocycle comprising a substituted or unsubstituted phenanthrenequinone unit and a graphite flake.2. The cathodic material of claim 1 , wherein the macrocycle comprises three substituted or unsubstituted phenanthrenequinone units in a triangular arrangement.5. The cathodic material of claim 1 , wherein macrocycle comprises a cationic aluminum complex.6. The cathodic material of claim 5 , wherein the macrocycle comprises three substituted or unsubstituted phenanthrenequinone units in a triangular arrangement and each of the phenathrenequinone units chelate a cationic aluminum center.9. The cathodic material of claim 1 , wherein the macrocycle is planar.10. The cathodic material of claim 1 , wherein the cathodic material comprises between about 2.0:1.0 and about 1.0:2.0 of the macrocycle to the graphite flake by weight.11. The cathodic material of claim 1 , wherein the cathodic material further comprises an electron-conducting additive.12. The cathodic material of claim 11 , wherein the electron-conducting additive is denka black.13. The cathodic material of claim 1 , wherein the cathodic material comprises a binder material.14. (canceled)15. An electrode comprising the cathodic material of and a substrate.16. A battery comprising a cathode claim 1 , the cathode comprising the cathodic material of and an electrolyte.17. The battery of claim 16 , wherein the electrolyte comprises an aluminum halide.18. The battery of claim 17 , wherein the electrolyte comprises tetrachloraluminate.19. The battery of claim 16 , wherein the electrolyte comprises an imidazolium.20. The battery of claim 19 , wherein the electrolyte comprises ethyl-3-methylimidazolium.21. The battery of further comprising an anode ...

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Номер записи: 79
16-10-2014 дата публикации

Cyclic compound, method for producing same, composition, and method for forming resist pattern

Номер: US20140308615A1
Автор: Masako Yamakawa, Masatoshi Echigo
Принадлежит: Mitsubishi Gas Chemical Co Inc

A cyclic compound having a molecular weight of 500 to 5000 is represented by the following formula (1), wherein at least one of R 0 is a monovalent group containing an iodine atom. Also disclosed are a method for producing the cyclic compound, a composition containing the cyclic compound, and a method for forming a resist pattern using the composition.

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Номер записи: 80
12-08-2021 дата публикации

TETRAHYDRO-1H-CYCLOPENTA[CD]INDENE DERIVATIVES AS HYPOXIA INDUCIBLE FACTOR-2(ALPHA) INHIBITORS

Номер: US20210246102A1
Автор: FU Jiping, He Yigang, Lou Yan
Принадлежит:

The present disclosure provides certain tetrahydro-1H-cyclopenta[cd]indene compounds that are Hypoxia Inducible Factor 2α (HIF-2α) inhibitors and are therefore useful for the treatment of diseases treatable by inhibition of HIF-2α. Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds. 146-. (canceled)74. The method of claim 68 , wherein the cancer is clear cell renal cell carcinoma.75. The method of claim 70 , wherein the cancer is clear cell renal cell carcinoma.76. The method of claim 72 , wherein the cancer is clear cell renal cell carcinoma. This application is an International Application claiming the benefit of U.S. Provisional Application No. 62/836,019 filed Apr. 18, 2019, and U.S. Provisional Application No. 62/946,191 filed Dec. 10, 2019; the entireties of which are herein incorporated by reference.The present disclosure provides certain tetrahydro-1H-cyclopenta[cd]indene compounds that are Hypoxia Inducible Factor 2α (HIF-2α) inhibitors and are therefore useful for the treatment of diseases treatable by inhibition of HIF-2α. Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds.Hypoxia is as an important regulator of both physiological and pathological processes, including various types of cancer, liver disease such as nonalcoholic steatohepatitis (NASH), inflammatory disease such as inflammatory bowel disease (IBD), pulmonary diseases such as pulmonary arterial hypertension (PAH), and iron load disorders.Hypoxia is well-known to drive cancer progression and is associated with poor patient prognosis, resistance to chemotherapy and radiation treatment. With the progress over the past several decades in elucidating molecular mechanisms that enable cellular adaptation to chronic oxygen deprivation, there is a strong interest in developing drugs that can effectively block the hypoxic response pathway in tumors. Among signaling modules, ...

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Номер записи: 81
18-07-2019 дата публикации

O-HYDROXY-FUNCTIONALIZED DIAMINES, POLYIMIDES, METHODS OF MAKING EACH, AND METHODS OF USE

Номер: US20190218345A1
Автор: Ghanem Bader S., Ma Xiaohua, Pinnau Ingo
Принадлежит:

Embodiments of the present disclosure provide for an ortho (o)-hydroxy-functionalized diamine, a method of making an o-hydroxy-functionalized diamine, an o-hydroxy-functionalized diamine-based polyimide, a method of making an o-hydroxy-functionalized diamine imide, methods of gas separation, and the like. 8. The composition of claim 1 , wherein x is 2 to 100 claim 1 ,000 and the polyimide includes two different Argroups.18. The membrane of claim 11 , wherein x is 2 to 100 claim 11 ,000 and the polyimide includes two different Argroups.20. The method of claim 19 , wherein x is 2 to 100 claim 19 ,000 and the polyimide includes two different Argroups. This application is a continuation of U.S. application Ser. No. 15/325,926, filed Jan. 12, 2017, under 35 U.S.C. 120, which claims the benefit of and priority to the National Stage of International Application No. PCT/IB2015/001396, filed 14 Jul. 2015, which claims the benefit of and priority to U.S. Provisional Application Ser. No. 62/024,487, having the title “O-HYDROXY-FUNCTIONALIZED DIAMINES, POLYIMIDES, METHODS OF MAKING EACH, AND METHODS OF USE,” filed on 15 Jul. 2014, the entire disclosures of which are incorporated by reference in their entireties as if fully set forth herein.Polyimides are among the most important high-performance glassy polymers that exhibit exceptional thermal, chemical, and mechanical properties. Polyimides have been used in many areas including the aerospace industry, electronic industry, high temperature adhesion, membranes for separation, composite materials, and the like. However, most polyimides exhibit poor processability due to their high melting points and limited solubility in organic solvents.Microporous polyimides have been developed to overcome these deficiencies, however, microporous polyimides are challenging to synthesize due, at least in part, to limitations of suitable reagents.Embodiments of the present disclosure provide for aromatic ortho-hydroxy-functionalized diamines, a ...

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Номер записи: 82
19-08-2021 дата публикации

Method for preparing 3(4),8(9)-bisformyltricyclo[5.2.1.0^2,6]decane

Номер: US20210253507A1
Автор: Hee Il CHAE, Jae Kyun PARK, Jeong Ho Park, Ju-Sik Kang, Kyung Sil YOON, Nam-Choul Yang, Song Lee, Yu Mi CHANG
Принадлежит: SK Chemicals Co Ltd

A method of preparing 3(4),8(9)-bisformyltricyclo[5.2.1.0 2,6 ]decane is provided. According to the present invention, 3(4),8(9)-bisformyltricyclo[5.2.1.0 2,6 ]decane (TCDDA) may be prepared with a high conversion rate and purity without a separate catalyst recovery process.

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Номер записи: 83
06-11-2014 дата публикации

Cyclic compound, method for producing the same, radiation-sensitive composition, and resist pattern formation method

Номер: US20140329178A1
Автор: Masako Yamakawa, Masatoshi Echigo
Принадлежит: Mitsubishi Gas Chemical Co Inc

A cyclic compound of the present invention has a molecular weight of 500 to 5000, and is represented by the following formula (1):

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Номер записи: 84
24-08-2017 дата публикации

NANODIAMONDS HAVING ACID FUNCTIONAL GROUP AND METHOD FOR PRODUCING SAME

Номер: US20170240429A1
Автор: YAMAKAWA Akira
Принадлежит: Daicel Corporation

A nanodiamond according to the present invention has acidic functional groups, contains the acidic functional groups in a number density of 1 or more per square nanometer in the nanodiamond surface, and has a specific surface area of 150 m/g or more. Particles of the nanodiamond preferably have a D50 (median diameter) of 9 nm or less. The nanodiamond is preferably derived from a nanodiamond synthesized by a detonation technique (in particular, an air-cooling detonation technique). 1. A nanodiamond having acidic functional groups ,the nanodiamond comprising the acidic functional groups in a number density of 1 or more per square nanometer in a surface of the nanodiamond,{'sup': '2', 'the nanodiamond having a specific surface area of 150 m/g or more.'}2. The nanodiamond according to claim 1 ,wherein particles of the nanodiamond have a D50 of 9 nm or less.3. The nanodiamond according to one of and claim 1 ,wherein the nanodiamond is a detonation nanodiamond.4. The nanodiamond according to claim 1 ,wherein the nanodiamond is an air-cooled detonation nanodiamond.5. The nanodiamond according to claim 1 ,wherein the nanodiamond is a nanodiamond obtained by subjecting a nanodiamond having an acidic functional group content of 0.15 mmol/g or more to an oxidation treatment.6. A method for producing the nanodiamond according to claim 1 , the method comprising the step ofA) subjecting a material nanodiamond to an oxidation treatment with at least one oxidizer selected from the group consisting of chromic acid, chromic anhydride, dichromic acid, permanganic acid, perchloric acid, salts of these acids, and hydrogen peroxide, the material nanodiamond being synthesized by a detonation technique and having an acidic functional group content of 0.15 mmol/g or more.7. The method according to for producing a nanodiamond claim 6 ,wherein the oxidation treatment in the step A) is performed in coexistence of sulfuric acid.8. The method according to one of and for producing a nanodiamond ...

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Номер записи: 85
01-08-2019 дата публикации

MATERIALS COATED WITH CALIXARENES

Номер: US20190233358A1
Автор: HAPIOT Philippe, JABIN Ivan, LAGROST Corinne, MATTIUZZI Alice, REINAUD Olivia
Принадлежит:

This invention relates to the direct grafting of a calixarene mostly onto the surface of a material, as well as to a grafting process, and certain calixarene intermediates useful for carrying the grafting process. 2. The (thia)calix[n]arene-diazonium salt according to claim 1 , wherein X is a chloride claim 1 , bromide claim 1 , or BF.4. A (thia)calix[n]-aniline of formula II as defined in claim 3 , wherein X claim 3 , R claim 3 , R claim 3 , R claim 3 , R claim 3 , R claim 3 , R claim 3 , and wherein Y claim 3 , Y claim 3 , Y claim 3 , Y claim 3 , Yare each independently selected from the group consisting of OH claim 3 , hydrogen claim 3 , NOor halogen; provided that the compound of formula (II) is not a calix[4]arene wherein X═CH claim 3 , R═R═R═R═Pr claim 3 , Y═Y═Y═NH claim 3 , or a calix[4]arene wherein X═CH claim 3 , R═R═R═Pr and R═CHCOOEt claim 3 , Y═Y═Y═NH claim 3 , or a calix[4]arene wherein X═CH claim 3 , R═R═R═R═OH claim 3 , Y═Y═Y═NH claim 3 , or a calix[4]arene wherein X═CH claim 3 , R═R═R═R=decyl claim 3 , Y═NH claim 3 , Y═Y═H claim 3 , or a calix[4]arene wherein X═CH claim 3 , R═R═R═R=decyl claim 3 , Y═NHY═Y═H claim 3 , or a calix[4]arene wherein X═CH claim 3 , R═R═R═R=decyl claim 3 , Y═Y═Y═H claim 3 , or a calix[4]arene wherein X═CH claim 3 , R═R═R═R═Pr claim 3 , Y═NH claim 3 , Y═Y═H claim 3 , or a calix[4]arene wherein X═CH claim 3 , R═R═R═R═Pr claim 3 , Y═NHY═Y═H claim 3 , or a calix[4]arene wherein X═CH claim 3 , R═R═R═R═Pr claim 3 , Y═Y═Y═H claim 3 , or a calix[4]arene wherein X═CH claim 3 , R═R═OH claim 3 , R═R=Me claim 3 , Y═NH claim 3 , Y═Y═H claim 3 , or a calix[4]arene wherein X═CH claim 3 , R═R═R═R=Me claim 3 , Y═Y═Y═NH claim 3 , or a calix[4]arene wherein X═CH claim 3 , R═R═R═R=Me claim 3 , Y═NH claim 3 , Y═Y═H claim 3 , or a calix[4]arene wherein X═CH claim 3 , R═R═OH claim 3 , R═R═Pr claim 3 , Y═NH claim 3 , Y═Y═H claim 3 , a calix[4]arene wherein X═CH claim 3 , R═R═R═R=undecyl claim 3 , Y═Y═Y═NH claim 3 , a calix[4]arene wherein X═CH ...

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Номер записи: 86
10-09-2015 дата публикации

Compounds for Electronic Devices

Номер: US20150255720A1
Автор: Anja Gerhard, Fabrice ECKES, Holger Heil, Lara-Isabel RODRIGUEZ, Oliver KAUFHOLD, Stefan RIEDMUELLER
Принадлежит: Merck Patent GmBH

The present invention relates to compounds which are suitable for use in electronic devices, preferably organic electroluminescent devices.

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Номер записи: 87
01-08-2019 дата публикации

ORGANIC ELECTROLUMINESCENCE DEVICE AND MONOAMINE COMPOUND FOR ORGANIC ELECTROLUMINESCENCE DEVICE

Номер: US20190237668A1
Автор: Itoi Hiroaki, Jin Xiulan, Miyake Hideo, Takada Ichinori, UENO Masatsugu, Uno Takuya
Принадлежит:

An organic electroluminescence device includes a first electrode, a hole transport region on the first electrode, an emission layer on the hole transport region, an electron transport region on the emission layer, and a second electrode on the electron transport region. The hole transport region includes a monoamine compound represented by the following Formula 1: 3. The organic electroluminescence device as claimed in claim 1 , wherein L is a substituted or unsubstituted arylene group having 6 to 12 ring carbon atoms.4. The organic electroluminescence device as claimed in claim 3 , wherein L is a substituted or unsubstituted phenylene group.5. The organic electroluminescence device as claimed in claim 1 , wherein Arand Arare each independently a substituted or unsubstituted aryl group having 6 to 12 ring carbon atoms.6. The organic electroluminescence device as claimed in claim 5 , wherein Arand Arare each independently a substituted or unsubstituted phenyl group claim 5 , a substituted or unsubstituted biphenyl group claim 5 , a substituted or unsubstituted naphthyl group claim 5 , or a substituted or unsubstituted fluorenyl group.7. The organic electroluminescence device as claimed in claim 1 , wherein Arand Arare each independently a substituted or unsubstituted heteroaryl group having 5 to 12 ring carbon atoms.8. The organic electroluminescence device as claimed in claim 7 , wherein Arand Arare each independently a substituted or unsubstituted dibenzofuran group claim 7 , a substituted or unsubstituted dibenzothiophene group claim 7 , or a substituted or unsubstituted carbazole group.9. The organic electroluminescence device as claimed in claim 1 , wherein Ris a hydrogen atom or a deuterium atom.10. The organic electroluminescence device as claimed in claim 1 , wherein the hole transport region has a plurality of layers claim 1 , and a layer of the plurality of layers contacting the emission layer includes the monoamine compound represented by Formula 1.11. The ...

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Номер записи: 88
01-09-2016 дата публикации

Materials for Electronic Devices

Номер: US20160254456A1
Автор: Amandine DARSY, Beate BURKHART, Holger Heil, Lara-Isabel RODRIGUEZ
Принадлежит: Merck Patent GmBH

The invention relates to compounds with benzindenofluorene base bodies and to the use thereof in electronic devices, in particular in organic electroluminescent devices.

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Номер записи: 89
23-07-2020 дата публикации

Organic electroluminescence device and monoamine compound for organic electroluminescence device

Номер: US20200235297A1
Автор: Hideo Miyake, HIROAKI Itoi, Ichinori Takada, Masatsugu Ueno, Takuya Uno, Xiulan Jin
Принадлежит: Samsung Display Co Ltd

An organic electroluminescence device includes a first electrode, a hole transport region on the first electrode, an emission layer on the hole transport region, an electron transport region on the emission layer, and a second electrode on the electron transport region. The hole transport region includes a monoamine compound represented by the following Formula 1:

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Номер записи: 90
08-09-2016 дата публикации

Composition for forming a resist underlayer film, and pattern-forming method

Номер: US20160259247A1
Автор: Fumihiro Toyokawa, Gouji Wakamatsu, Shin-Ya Nakafuji
Принадлежит: JSR Corp

A composition for forming a resist underlayer film is provided, which contains: a calixarene-based compound obtained from a calixarene by substituting at least a part of hydrogen atoms each on phenolic hydroxyl groups comprised in the calixarene, with a monovalent organic group having 1 to 30 carbon atoms; and an organic solvent. The monovalent organic group preferably includes a crosslinkable group. A part of hydrogen atoms each on phenolic hydroxyl groups of the calixarene-based compound is preferably substituted. The ratio of the number of substituted phenolic hydroxyl groups to the number of unsubstituted phenolic hydroxyl groups in the calixarene-based compound is preferably no less than 30/70 and no greater than 99/1.

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Номер записи: 91
21-09-2017 дата публикации

PLEUROMUTILIN DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY MICROBES

Номер: US20170266194A1
Автор: Badegruber Rudolf, BULUSU Atchyuta Rama Chandra Murty, Ferencic Mathias, Heilmayer Werner, Mang Rosemarie, Novak Rodger, Strickmann Dirk B.
Принадлежит:

A compound of formula (I) wherein n is 0 to 4; m is 0 or 1 with the proviso that the sulphur atom and Rare in vicinal position (if m=0 then Ris in position 2′, and if m=1 then Ris on position 1′); R is ethyl or vinyl; Ris hydrogen or (C1-6)alkyl; Ris hydrogen or—(C)cycloalkyl, or—unsubstituted (C)alkyl, or—(C)alkyl substituted by one or more of—hydroxy; preferably one or two,—methoxy,—halogen,—(C)cycloalkyl, or Rand Rtogether with the nitrogen atom to which they are attached form a 5 to 7 membered heterocyclic ring containing at least 1 nitrogen atom or 1 nitrogen and 1 additional heteroatome e. g. selected from N or O, or Ris hydroxy and Ris formyl; Ris OH, OR, a halogen atom, or—with the proviso that Ris bound to 2′ Rrepresents —O—(CH)P—O— with p is 2 or 3; Ris unsubstituted (C)alkyl or (C)cycloalkyl.

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Номер записи: 92
20-09-2018 дата публикации

METHOD OF FORMING PARACYCLOPHANE CONTAINING FUNCTIONAL GROUND WITH DISULFIDE BOND

Номер: US20180265460A1
Автор: Chen Hsien-Yeh, Guan Zhen-Yu, Wu Chih-Yu
Принадлежит:

The present invention provides a method of forming paracyclyophane containing disulfide functional group. The paracyclophane is prepared by adding 3,3′-dithiodipropionic acid (DPDPA) and N-ethyl-N′-(3-(dimethylamino)propyl)carbodiimide (EDC) into 4-aminomethyl [2,2] paracyclophane. The present invention further provides a chemical film and a method of forming the same. The chemical film contains poly-p-xylylene with disulfide functional group and is formed on a substrate by a chemical vapor deposition process. 1. A method of forming paracyclophane containing disulfide functional group , comprising:adding 3,3′-dithiodipropionic acid (DPDPA) and N-ethyl-N′-(3-(dimethylamino)propyl)carbodiimide (EDC) into 4-aminomethyl [2,2] paracyclophane, thereby obtaining a paracyclophane comprising a disulfide functional group.2. The method of forming paracyclophane containing disulfide functional group according to claim 1 , wherein the disulfide functional group comprises a thiol-disulfide carboxylic acid end.3. The method of forming paracyclophane containing disulfide functional group according to claim 1 , wherein the paracyclophane is 4-(3-((3-methylamido)-disulfide) propanoic acid) [2 claim 1 ,2] paracyclophane.4. The method of forming paracyclophane containing disulfide functional group according to claim 1 , wherein 4-aminomethyl [2 claim 1 ,2] paracyclophane is prepared by:{'sub': 6', '4', '2', '2', '4, 'adding potassium phthalimide (KCH(CO)N) and hydrazine (NH) into 4-bromomethyl [2,2] paracyclophane to form 4-aminomethyl [2,2] paracyclophane.'}5. The method of forming paracyclophane containing disulfide functional group according to claim 4 , wherein 4-bromomethyl [2 claim 4 ,2] paracyclophane is prepared by:{'sub': '3', 'adding phosphorus tribromide (PBr) into 4-hydroxymethyl [2,2] paracyclophane, to form 4-bromomethyl [2,2] paracyclophane.'}6. The method of forming paracyclophane containing disulfide functional group according to claim 5 , wherein 4-hydroxymethyl [2 ...

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Номер записи: 93
20-09-2018 дата публикации

TRIPTYCENE DERIVATIVES FOR NUCLEIC ACID JUNCTION STABILIZATION

Номер: US20180265911A1
Автор: BARROS Stephanie A., CHENOWETH David M.
Принадлежит:

The present invention is directed to compositions and methods using triptycene derivatives (TCDs) for three way junctions (TWJs). 1. A method of screening for triptycene derivative (TCD) compounds that stabilize a target nucleic acid three way junction (TWJ) structures comprising:a) providing an array comprising a solid support comprising a plurality of assay locations each comprising a covalently attached different TCD; i) a nucleic acid substrate with an attached fluorophore donor and an attached fluorophore acceptor; and', 'ii) a nucleic acid inhibitor that hybridizes to said substrate to form an inhibitor complex such that said donor and acceptor are separated and FRET does not occur, wherein said contacting is done under conditions wherein one of said TCDs binds to said TWJ such that said inhibitor is released and that FRET occurs; and, 'b) contacting said array with a target TWJ comprisingd) determining the binding of said TCD to said TWJ by detecting the presence or absence of FRET.2. A method of screening for triptycene derivative (TCD) compounds that stabilize a target nucleic acid three way junction (TWJ) structures comprising:a) providing a target nucleic acid substrate with an attached fluorophore donor and an attached fluorophore acceptor, said substrate forming a TWJ such that said donor and acceptor undergo fluorescence resonance energy transfer (FRET);b) contacting said substrate with a nucleic acid inhibitor that hybridizes to said substrate to form an inhibitor complex such that said donor and acceptor are separated and FRET does not occur;c) contacting said inhibited complex with a triptycene derivative (TCD) under conditions wherein said inhibitor is released and said TCD binds to said TWJ such that FRET reoccurs; andd) determining the binding of said TCD to said TWJ by detecting the presence or absence of FRET.3. A method of screening for triptycene derivative (TCD) compounds that stabilize nucleic acid three way junction (TWJ) structures ...

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Номер записи: 94
29-09-2016 дата публикации

Method of producing ingenol-3-angelate

Номер: US20160280627A1
Автор: Anders Klarskov Petersen, Anne Marie Horneman, Gunnar Grue-Sørensen, Thomas Högberg, Xifu Liang
Принадлежит: Leo Laboratories Ltd

The present invention relates to methods of producing ingenol-3-angelate (I) from ingenol (II). Furthermore, the invention relates to intermediates useful for the synthesis of ingenol-3-angelate (I) from ingenol (II) and to methods of producing said intermediates.

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Номер записи: 95
29-08-2019 дата публикации

ORGANIC ELECTROLUMINESCENT DEVICE

Номер: US20190263735A1
Автор: Cai Lifei, CHEN Jinxin, LI Zhe, LOW Kam-Hung
Принадлежит:

This invention relates to an OLED, comprising an anode, a cathode, and an organic layer, the organic layer at least contains one or more layers containing light emitting layer from the hole injection layer, hole transport layer, electron injection layer, electron transport layer, light emitting layer; the light emitting layer is a host guest doping system composed of host materials and guest materials. The light-emitting zone of the light emitting layer is 490-750 nm, and the host material has a structure with the formula (I). The OLED can emit red or green light, with the advantages of excellent light emitting efficiency, excellent color purity and long lifetime. 2. The OLED according to claim 1 , wherein R-Rindependently represent hydrogen claim 1 , halogen claim 1 , cyano claim 1 , nitro claim 1 , C1-C8 alkyl claim 1 , C1-C8 alkoxy claim 1 , C2-C8 substituted or unsubstituted alkenyl claim 1 , C2-C8 substituted or an unsubstituted alkynyl claim 1 , C1-C4 alkyl substituted or unsubstituted phenyl claim 1 , C1-C4 alkyl substituted or unsubstituted naphthyl claim 1 , or combined C1-C4 alkyl substituted or unsubstituted fluorenyl; Ar-Arindependently represent C1-C4 alkyl or C6-C30 aryl-substituted phenyl claim 1 , C1-C4 alkyl or C6-C30 aryl-substituted naphthyl claim 1 , phenyl claim 1 , naphthyl claim 1 , pyridyl claim 1 , N-C6-C30 aryl or C1-C4 alkyl-substituted carbazolyl claim 1 , dibenzothienyl claim 1 , dibenzofuranyl claim 1 , anthryl claim 1 , phenanthryl claim 1 , pyrenyl claim 1 , perylenyl claim 1 , fluoranthenyl claim 1 , (9 claim 1 ,9)-dialkyl) fluorenyl claim 1 , (9 claim 1 ,9-dialkyl substituted or unsubstituted aryl) fluorenyl claim 1 , 9 claim 1 ,9-spirofluorenyl.3. The OLED according to claim 2 , wherein R-Rindependently and preferably represent hydrogen claim 2 , halogen claim 2 , C1-C4 alkyl claim 2 , C1-C4 alkyl substituted or unsubstituted phenyl claim 2 , C1-C4 alkyl substituted or unsubstituted naphthyl claim 2 , or combined C1-C4 alkyl- ...

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Номер записи: 96
29-08-2019 дата публикации

RUNX2 Transcription Factor Inhibitors and Uses Thereof

Номер: US20190263751A1
Автор: Jr. Alexander D., MacKerell, Passaniti Antonino
Принадлежит:

Provide herein are compounds with a general chemical structure of: 2. The compound of claim 1 , wherein Ris NH.5. The compound of claim 1 , wherein Rand Rare each Cl and Ris NH.7. A pharmaceutical composition comprising the compound of and a pharmaceutically acceptable carrier.9. A pharmaceutical composition comprising the compound of and a pharmaceutically acceptable carrier. This application is a divisional under 35 U.S.C. § 120 of pending application U.S. Ser. No. 15/708,872, filed Sep. 19, 2017, which is a continuation-in-part under 35 U.S.C. § 120 of international application PCT/US2016/023257, filed Mar. 18, 2016, now abandoned, which claims benefit of priority under 37 C.F.R. § 1.119(e) of provisional application U.S. Ser. No. 62/135,224, filed Mar. 19, 2015, now abandoned, the entirety of all of which is hereby incorporated by reference.This invention was made with government support under Grant Number CA108846 awarded by the National Institutes of Health. The government has certain rights in the invention.The present invention relates to RUNX2 transcription factor inhibitors and their uses in cancer treatment. More specifically, the invention relates to derivatives and analogs of the RUNX2 transcription factor inhibitor compound 1 and their uses in treating breast cancer.Breast cancer is a heterogeneous disease and despite advances in treatment, it remains the second leading cause of cancer-related deaths among women. Luminal breast cancer has the highest rates of relapse, often localizes to the bone, and accounts for 50% of all metastatic-related breast cancer deaths in spite of the primary tumor being highly responsive to treatment. Given their high rate of relapse, it is clear current treatment modalities are insufficient to completely eradicate these heterogeneous tumors.The HER2-targeted agent trastuzumab is the only FDA-approved for use in patients whose tumors are clinically defined as HER2 amplified. Early clinical trials have shown a 50% reduction ...

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Номер записи: 97
28-09-2017 дата публикации

TRIPTYCENE DERIVATIVE USEFUL AS MATERIAL FOR FORMING SELF-ASSEMBLED FILM, METHOD FOR MANUFACTURING SAID TRIPTYCENE DERIVATIVE, FILM USING SAME, METHOD FOR MANUFACTURING SAID FILM, AND ELECTRONIC DEVICE USING SAID METHOD

Номер: US20170279058A1
Автор: Fukushima Takanori, Ishiwari Fumitaka, SEKITANI Tsuyoshi, Shoji Yoshiaki, SOMEYA Takao
Принадлежит: JAPAN SCIENCE AND TECHNOLOGY AGENCY

The present invention pertains to: a Janus-type triptycene derivative which is capable of forming a self-assembled film which does not depend on the material quality of a substrate; a self-assembled film using said Janus-type triptycene derivative; a structure having said film on a surface thereof; a method for manufacturing said film; and an electronic device using said method. 2. The Janus-type triptycene derivative according to claim 1 , wherein X in Formula [I] is a divalent group represented by —CH— claim 1 , —CH═CH— claim 1 , —O— claim 1 , or —NR— (wherein Rrepresents a hydrogen atom or an alkyl group having from 1 to 4 carbon atoms).3. The Janus-type triptycene derivative according to claim 1 , wherein Rin Formula [I] is an alkylene group having from 2 to 30 carbon atoms claim 1 , an alkenylene group having from 2 to 30 carbon atoms claim 1 , an alkynylene group having from 2 to 30 carbon atoms claim 1 , or a divalent arylene group which contains at least one aryl ring having from 6 to 30 carbon atoms and in which total carbon atoms are from 6 to 60.4. The Janus-type triptycene derivative according to claim 1 , wherein Z in Formula [I] is a hydrogen atom claim 1 , a haloalkyl group having from 1 to 10 carbon atoms claim 1 , an alkenyl group having from 2 to 10 carbon atoms claim 1 , an alkynyl group having from 2 to 10 carbon atoms claim 1 , a hydroxyl group claim 1 , —COOR(wherein Rrepresents a hydrogen atom or an alkyl group which has from 1 to 5 carbon atoms and may have at least one substituent) claim 1 , —N(R)(wherein Rmay be the same as or different from each other and represents a hydrogen atom claim 1 , an alkyl group which has from 1 to 5 carbon atoms and may have at least one substituent claim 1 , or an aryl group which has from 6 to 30 carbon atoms and may have at least one substituent) claim 1 , or —P(═O)(OR)(wherein each of Rindependently represents a hydrogen atom claim 1 , an alkyl group having from 1 to 10 carbon atoms claim 1 , or an aryl ...

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Номер записи: 98
10-09-2020 дата публикации

PLEUROMUTILIN DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY MICROBES

Номер: US20200281933A1
Автор: Badegruber Rudolf, BULUSU Atchyuta Rama Chandra Murty, Ferencic Mathias, Heilmayer Werner, Mang Rosemarie, Novak Rodger, Strickmann Dirk
Принадлежит:

Pleuromutilin derivative compounds of the following formula (I), and uses thereof for the treatment of diseases mediated by microbes, are disclosed: 7. A compound according to one of the to , selected from the group consisting of14-O-{[(1R, 2R, 4R)-4-Amino-2-hydroxy-cyclohexylsulfanyl]-acetyl}-mutilin14-O-{[(1S, 2S, 4S)-4-Amino-2-hydroxy-cyclohexylsulfanyl]-acetyl}-mutilin14-O-{[(1R, 2R, 5S)-5-Amino-2-hydroxy-cyclohexylsulfanyl]-acetyl}-mutilin14-O-{[(1S, 2S, 5R)-5-Amino-2-hydroxy-cyclohexylsulfanyl]-acetyl}-mutilin14-O-{[(1R, 2R, 4S)-4-Amino-2-hydroxy-cyclohexylsulfanyl]-acetyl}-mutilin and the (1S, 2S, 4R) diastereomer thereof14-O-{[(1R, 2R, 5R)-5-Amino-2-hydroxy-cyclohexylsulfanyl]-acetyl}-mutilin14-O-{[(1S, 2S, 5S)-5-Amino-2-hydroxy-cyclohexylsulfanyl]-acetyl}-mutilin14-O-{[(1R, 2R, 3R)-3-Amino-2-hydroxy-cyclohexylsulfanyl]-acetyl}-mutilin and the (1S, 2S, 3S) diastereomer thereof14-O-{[(1R, 2R, 4R)-4-Diethylamino-2-hydroxy-cyclohexylsulfanyl]-acetyl}-mutilin and the (1S, 2S, 4S) diastereomer thereof14-O-{[(1R, 2R, 4R)-4-Ethylamino-2-hydroxy-cyclohexylsulfanyl]-acetyl}-mutilin and the (1S, 2S, 4S) diastereomer thereof14-O-{[(1R, 2R, 5S)-5-Ethylamino-2-hydroxy-cyclohexylsulfanyl]-acetyl}-mutilin and the (1S, 2S, 5R) diastereomer thereof14-O-{[(1R, 2R, 5S)-5-Diethylamino-2-hydroxy-cyclohexylsulfanyl]-acetyl}-mutilin and the (1S, 2S, 5R) diastereomer thereof14-O-{[(1R, 2R, 4S)-4-Diethylamino-2-hydroxy-cyclohexylsulfanyl]-acetyl}-mutilin and the (1S, 2S, 4R) diastereomer thereof14-O-{[(1R, 2R, 5R)-5-Diethylamino-2-hydroxy-cyclohexylsulfanyl]-acetyl}-mutilin and the (1S, 2S, 5S) diastereomer thereof14-O-{[(1R, 2R, 3R)-3-Ethylamino-2-hydroxy-cyclohexylsulfanyl]-acetyl}-mutilin and the S, 2S, 3S) diastereomer thereof14-O-{[(1R, 2R, 3R)-3-Diethylamino-2-hydroxy-cyclohexylsulfanyl]-acetyl}-mutilin and the (1S, 2S, 3S) diastereomer thereof14-O-{[(1R, 2R, 4S)-4-(Formyl-hydroxy-amino)-2-hydroxy-cyclohexylsulfanyl]-acetyl}-mutilin and the (1S, 2S, 4R) diastereomer thereof14- ...

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Номер записи: 99
19-09-2019 дата публикации

SPIROBIFLUORENE COMPOUND AND PEROVSKITE SOLAR CELL COMPRISING SAME

Номер: US20190288207A1
Автор: JEON Nam Joong, LEE Jaemin, NA Hye Jin, NOH Jun Hong, SEO Jang Won, SEOK Sang Il, YANG Tae Youl
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A spirobifluorene compound and a perovskite solar cell including the spirobifluorene compound are disclosed. More particularly, a spirobifluorene compound which can be used as a hole transport material of a perovskite solar cell is disclosed. A perovskite solar cell including the spirobifluorene compound as a hole transport material is further disclosed. 2. The spirobifluorene compound of claim 1 , wherein Rto Rare independently of one another (C6-C12)aryloxy claim 1 , (C6-C12)arylthio claim 1 , or (C1-C10)alkoxy.3. The spirobifluorene compound of claim 1 , wherein in Chemical Formula 1 claim 1 ,{'sub': 11', '12', '11', '12, 'Rand Rare independently of each other hydrogen, (C1-C20)alkyl, (C6-C20)aryl, or (C3-C20)heteroaryl, or Rand Rare linked to each other to form an aromatic ring-fused spirocycle;'}{'sub': 13', '16, 'Rto Rare independently of one another hydrogen, (C1-C10)alkyl, or (C1-C10)alkoxy;'}R is (C1-C10)alkyl or (C1-C10)alkoxy; andn is 0 or an integer of 1 to 3.5. The spirobifluorene compound of claim 4 , wherein{'sub': 1', '4, 'Rto Rare independently of one another (C1-C10)alkoxy or (C6-C12)aryloxy;'}{'sub': 11', '12', '11', '12, 'Rand Rare independently of each other (C1-C20)alkyl or (C6-C20)aryl, or Rand Rare linked to each other to form an aromatic ring-fused spirocycle;'}{'sub': 13', '16, 'Rto Rare independently of one another hydrogen or (C1-C7)alkoxy; and'}n is 0.7. A perovskite solar cell comprising the spirobifluorene compound of .8. (canceled)9. The perovskite solar cell of claim 7 , wherein the perovskite solar cell comprises a first electrode claim 7 , an electron transport layer formed over the first electrode claim 7 , a light absorption layer formed over the electron transport layer claim 7 , a hole transport layer formed over the light absorption layer claim 7 , and a second electrode formed over the hole transport layer claim 7 , wherein the light absorption layer comprises a perovskite compound claim 7 , wherein the hole transport layer ...

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Номер записи: 100