POLYGLYCOL ETHER-FREE SULPHOSUCCINATES BASED ON POLYGLYCEROL PARTIAL ESTERS AND USE THEREOF

The invention relates to polyglycol ether-free, polyglycerol partial ester-based sulphosuccinates, the preparation thereof, and the use of these in cosmetic formulations and also in cleaning compositions in the industrial and domestic sector and formulations comprising these sulphosuccinates. 2. The sulphosuccinate according to claim 1 , wherein R claim 1 , R claim 1 , R═H and wherein on statistical average claim 1 , said sulphosuccinate has a weight ratio of carboxylic acid ROH to polyglycerol basic backbone of 0.10:1 to 0.50:1.3. The sulphosuccinate according to claim 1 , wherein said sulphosuccinate has an average degree of polymerization n of 2 to 11.4. The sulphosuccinate according to claim 1 , wherein R=an acyl radical of a fatty acid selected from the group consisting of oenanthic acid claim 1 , caprylic acid claim 1 , pelargonic acid claim 1 , capric acid claim 1 , lauric acid claim 1 , myristic acid claim 1 , pentadecanoic acid claim 1 , palmitic acid claim 1 , margaric acid claim 1 , stearic acid claim 1 , undecylenic acid claim 1 , myristoleic acid claim 1 , palmitoleic acid claim 1 , petroselic acid claim 1 , oleic acid claim 1 , elaidic acid claim 1 , vaccenic acid claim 1 , linoleic acid claim 1 , α-linolenic acid claim 1 , γ-linolenic acid claim 1 , calendic acid claim 1 , punicic acid claim 1 , α-elaeostearic acid claim 1 , β-elaeostearic acid claim 1 , and mixtures thereof.5. The sulphosuccinate according to claim 1 , wherein R is selected from sulphosuccinic acid radicals of the formula IIa or IIb.6. The sulphosuccinates according to claim 1 , wherein Ris selected from sulphomethylsuccinic acid radicals of the formula IIc or IId.7. The sulphosuccinate according to claim 1 , wherein R=the acyl radical of a natural fatty acid selected from the group consisting of caprylic acid claim 1 , capric acid claim 1 , lauric acid claim 1 , and coconut fatty acid mixtures and Ris selected from sulphosuccinic acid radicals of the formula IIa or IIb.8. A process ...

PROCESS FOR PREPARATION OF ISOSULFAN BLUE

A process for the preparation of isosulfan blue (Active Pharmaceutical Ingredient) is provided. A process is also provided for preparation of the intermediate, 2-chlorobenzaldehyde-5-sulfonic acid, sodium salt of formula (2), used in the preparation thereof and a procedure for the isolation of benzaldehyde-2,5-disulfonic acid, di-sodium salt of the formula (3). Also provided is a process for the preparation of an isoleuco acid of formula (4), which upon mild oxidation gives rise to isosulfan blue of pharmaceutical grade which can be used for preparation of pharmaceutical formulations. The isolation and purification procedures provided in the process provide substantially pure isosulfan blue with HPLC purity 99.5% or greater. 3. The process of preparing 2-chlorobenzaldehyde-5-sulfonic acid claim 2 , sodium salt of formula (2) according to comprising reacting 2-chlorobenzaldehyde with sulfuric acid.4. The process according to wherein the polar solvent is methanol.6. The process according to wherein the reaction is carried out in a pressure vessel at 170-180° C. for 5 to 7 hours.7. The process according to wherein the reaction is carried out under a pressure of 140 to 150 psi.8. The process according to comprising precipitating inorganic salts which will hinder the rate of reaction using methanol or one or more Clower alcohols.9. The process according to in which the benzaldehyde-2 claim 2 ,5-disulfonic acid disodium salt is purified by extracting with a non-aqueous polar solvent followed by its precipitation in a halogenated or non-halogenated non-polar solvent which is miscible with the non-aqueous polar solvent.10. The process according to wherein the nonaqueous polar solvent is N claim 9 ,N dimethylformamide and the nonpolar solvent is dichloromethane.12. The process according to performed at reflux conditions for 20-25 hours at 115 to 120° C.13. The process according to comprising precipitating a crude solid using methanol or a Clower alcohol.14. The process ...

PROCESS FOR FLUORINATION OF SULPHONYL HALIDE COMPOUNDS

The present disclosure relates to the preparation of a compound of formula (I) comprising an —SOF function, R—SOF, by reacting a compound of formula (II), R′—SOX, with a fluorinating agent, the process carried out in the liquid phase in the presence of hydrofluoric acid using an antimony-based fluorination catalyst, wherein R, R′, and X are described herein. 1. A non-electrochemical process for preparing a fluorinated compound of formula (I) comprising at least one —SOF function , wherein the compound of formula (I) is prepared by reacting a compound of formula (II) with at least one fluorinating agent , wherein the process is carried out in the liquid phase in the presence of hydrofluoric acid using an antimony-based fluorination catalyst:{'br': None, 'sub': '2', 'R—SOF \u2003\u2003(I)'}where R is selected from the group consisting of R1, R2 and R3:{'sub': n', 'a', 'b, 'R1=—CHFwith n=1-10, a+b=2n+1, b≧1;'}{'sub': x', 'y', 'z', '2, 'R2=—CHF—SOF with x=1-10, y+z=2x and z≧1;'}{'sub': c', 'h', 'f, 'claim-text': {'br': None, 'sub': '2', 'R′—SOX \u2003\u2003(II)'}, 'R3=Φ-CHFwith c=1-10; h+f=2c and f≧1; Φ denoting a phenyl group;'}where R′ is selected from the group consisting of R′1, R′2 and R′3:{'sub': n', 'a', 'b, 'R′1=—CHXwith n=1-10, a+b=2n+1, b≧1;'}{'sub': x', 'y', 'z', '2, 'R′2=—CHX—SOX with x=1-10, y+z=2x and z≧1;'}{'sub': c', 'h', 'f, 'R′3=Φ-CHXwith c=1-10; h+f=2c and f≧1; Φ denoting a phenyl group;'}X is a halogen atom selected from the group consisting of chlorine and bromine.2. The preparation process as claimed in claim 1 , wherein the radicals R1 and R′1 are perhalogenated so that b=3 and a=0.3. The preparation process as claimed in claim 1 , wherein the radical R of the compound (I) is the radical R1 wherein n=1 claim 1 , a=0 and b=3 claim 1 , or n=1 claim 1 , a=1 claim 1 , b=2 or else n=1 claim 1 , a=2 and b=1.4. The preparation process as claimed in claim 1 , wherein the compound of formula (II) is obtained by radical halogenation of a compound of formula ...

METHODS FOR PROMOTING MYELINATION AND FOR TREATING DEMYELINATING DISEASES

This invention provides novel methods for treating or ameliorating symptoms of demyelinating diseases such as multiple sclerosis. The methods involve administering to subjects in need of treatment a pharmaceutical composition that contains a therapeutically effective amount of taurine and also a compound that induces oligodendrocyte precursor cell (OPC) differentiation (e.g., T3, benztropine, clemastine or miconazole). Some of the methods additionally involve administration to the subject a known agent for treating demyelinating diseases (e.g., SIP receptor agonists) or a known disease modifying drug. The invention also provides methods for increasing myelination and methods for promoting OPC differentiation into oligodendrocytes. These methods entail contacting a population of OPCs with a combination of taurine and a known OPC differentiation-inducing agent such as T3, clemastine, benztropine or miconazole. 1. A method for treating or ameliorating one or more symptoms of a demyelinating disease in a subject , comprising administering to the subject (a) a pharmaceutical composition comprising a therapeutically effective amount of taurine or a taurine-like compound and (b) an agent that induces oligodendrocyte precursor cell (OPC) differentiation (OPC differentiation-inducing agent) , thereby treating or ameliorating the symptoms of the demyelinating disease in the subject.2. The method of claim 1 , wherein the taurine or taurine-like compound is administered to the subject simultaneously with claim 1 , prior to claim 1 , or subsequent to administration of the OPC differentiation-inducing agent.3. The method of claim 1 , wherein the taurine-like compound is an agent that can directly or indirectly upregulate the serine level in an OPC claim 1 , pre-myelinating oligodendrocyte claim 1 , or oligodendrocyte claim 1 , thereby enhancing glycosphingolipid biosynthesis in the OPC claim 1 , pre-myelinating oligodendrocyte claim 1 , or oligodendrocyte.4. The method of claim 1 ...

METHODS FOR PRODUCING ALKYLBENZENES, PARAFFINS, OLEFINS AND OXO ALCOHOLS FROM WASTE PLASTIC FEEDSTOCKS

The present invention relates generally to methods for producing detergent compounds from waste plastic feedstocks. More specifically, the invention relates to methods for producing detergent intermediates, including alkylbenzenes, paraffins, olefins, oxo alcohols, and surfactant derivatives thereof from waste plastic feedstock. 1. A method for producing paraffin from waste plastic feedstock and kerosene and/or another source(s) of hydrocarbons comprising the steps of:providing a first feed stream comprising kerosene and/or another source(s) of hydrocarbons;pre-fractionating the first feed stream to produce a first heart cut paraffin stream comprising paraffins in a heart cut range;combining the first heart cut paraffin stream with a second feed stream comprising waste plastic feedstock to form a combined stream;hydrotreating the combined stream; andfractionating the hydrotreated stream to remove paraffins that are heavier and/or lighter than the heart cut range to form a second heart cut paraffin stream.2. The method according to claim 1 , further comprising the step of separating branched and cyclic hydrocarbons from the second heart cut paraffin stream to form a linear heart cut paraffin stream.3. The method according to claim 1 , further comprising the step of separating branched and cyclic hydrocarbons from the combined stream to form a linear combined stream.4. A method for producing paraffin from waste plastic feedstock and kerosene and/or another source(s) of hydrocarbons comprising the steps of:providing a first feed stream comprising kerosene and/or another source(s) of hydrocarbons;pre-fractionating the first feed stream to produce a first heart cut paraffin stream comprising paraffins in a heart cut range;hydrotreating a second feed stream comprising waste plastic feedstock;combining the first heart cut paraffin stream with the hydrotreated second feed stream to form a combined stream;hydrotreating the combined stream; andfractionating the hydrotreated ...

Fracturing fluid comprising a (co)polymer of a hydrated crystalline form of 2-acrylamido-2-methylpropane sulphonic acid and hydraulic fracturing method

The present invention relates to a fracturation fluid comprising at least one propping agent and at least one water-soluble (co)polymer prepared from the hydrated crystalline form of 2-acrylamido-2-methylpropane sulfonic acid and/or at least one of its salts. The invention relates to a process to prepare said fluid, and to a hydraulic fracturation process using said fluid.

Cyclic Process for Producing Taurine from Monoethanolamine

There is disclosed a cyclic process for producing taurine from monoethanolamine comprising the steps of: (a) recovering monoethanolamine sulfate from an aqueous mother liquor solution; (b) reacting the monoethanolamine sulfate with sulfuric acid to form an aqueous solution comprised of monoethanolamine bisulfate; (c) heating the aqueous solution comprised of the monoethanolamine sulfate and optionally added monoethanolamine sulfate to yield 2-aminoethyl hydrogen sulfate ester; (d) reacting the ester with ammonium sulfite or an alkali sulfite to yield taurine and ammonium or alkali sulfate; (e) separating taurine and ammonium or alkali sulfate to give an aqueous mother liquor solution; and (f) recovering the monoethanolamine sulfate from the aqueous mother liquor solution and recycling to the monoethanolamine sulfate to step (b). 1. A process for recovering monoethanolamine sulfate from an aqueous mother liquor solution , comprising:(a) removing ammonium sulfite from an aqueous mother liquor solution comprised of monoethanolamine sulfate, ammonium sulfate, and ammonium sulfite to yield an aqueous solution comprised of the monoethanolamine sulfate and ammonium sulfate;(b) concentrating the aqueous solution of step (a) to crystallize the ammonium sulfate; and(c) separating the ammonium sulfate of step (b) by solid-liquid separation to yield an aqueous solution comprised of the monoethanolamine sulfate.2. A process for recovering monoethanolamine sulfate from an aqueous mother liquor solution , comprising:(a) removing alkali sulfite from an aqueous mother liquor solution comprised of monoethanolamine sulfate, alkali sulfate, and alkali sulfite to yield an aqueous solution comprised of the monoethanolamine sulfate and alkali sulfate, wherein the alkali is lithium, sodium, potassium, or a mixture thereof;(b) concentrating the aqueous solution of step (a) to crystallize the alkali sulfate; and(c) separating the alkali sulfate of step (b) by solid-liquid separation to yield ...

PROCESS FOR PREPARATION OF ISOSULFAN BLUE

Isosulfan blue and processes for the preparation thereof are provided. A process is also provided for preparation of the intermediate, 2-chlorobenzaldehyde-5-sulfonic acid, sodium salt of formula (2), used in the preparation thereof and a procedure for the isolation of benzaldehyde-2,5-disulfonic acid, di-sodium salt of the formula (3). Also provided is a process for the preparation of an isoleuco acid of formula (4), which upon oxidation gives rise to isosulfan blue of pharmaceutical grade which can be used for preparation of pharmaceutical formulations. The isolation and purification procedures provided in the process provide substantially pure isosulfan blue with HPLC purity 99.5% or greater. 1. A compound N-[4-[[4-(diethyl amino)phenyl](2 ,5-di sulfophenyl)methylene]-2 ,5-cyclohexadien-1-ylidene]-N-ethylethanaminium , sodium salt having a purity of at least 99.0% by HPLC.2. The compound according to having a purity between 99.0% and 99.5% by HPLC.3. The compound according to having less than 20 ppm silver.4. The compound according to having a purity greater than 99.5% by HPLC.7. The compound according to wherein the process of preparing 2-chlorobenzaldehyde-5-sulfonic acid claim 6 , sodium salt of formula (2) comprises reacting 2-chlorobenzaldehyde with sulfuric acid.8. The compound according to wherein the polar solvent is methanol.10. The compound according to wherein the process comprises recrystallization of N-[4-[[4-(diethylamino)phenyl](2 claim 5 ,5-disulfophenyl)methylene]-2 claim 5 ,5-cyclohexadien-1-ylidene]-N-ethylethanaminium using a solvent selected from the group consisting of a polar solvent claim 5 , a non-polar solvent and a combination thereof to afford HPLC purity greater than 99.5%.11. A solution containing N-[4-[[4-(diethyl amino)phenyl](2 claim 5 ,5-disulfophenyl) methylene]-2 claim 5 ,5-cyclohexadien-1-ylidene]-N-ethylethanaminium claim 5 , sodium salt claim 5 , the N-[4-[[4-(diethyl amino)phenyl](2 claim 5 ,5-disulfophenyl)methylene]-2 ...

METHOD AND SYSTEM FOR REMOVING IMPURITIES OUT OF TAURINE MOTHER LIQUOR AND TAURINE MOTHER LIQUOR RECOVERY

A method and production system for removing impurities from a taurine mother liquor and recovering the taurine mother liquor recovery. The method and system can be used in an ethylene oxide production process for taurine and the treatment of the last mother liquor of taurine. The last mother liquor of taurine is ion-exchanged through an anion exchange resin; then the anion exchange resin is eluted and regenerated with alkaline solution, and the outlet material liquor is collected; (b) the collected outlet material liquor is subjected to ammonia mixing treatment, and the mother liquor is generated after the impunity is removed and the separation of the solid and liquor; (c) the generated mother liquor is then returned to the ammonolysis step of taurine production. After the last mother liquor of taurine is treated by the anion exchange resin, more impurities in the last mother liquor can be removed, and salt is further removed by ammonia mixing treatment to generate a pure taurine mother liquor, thereby realizing the recovery of the mother liquor and improving the product yield. 1. A method for removing impurities from the last mother liquor of taurine in an ethylene oxide production process for producing taurine , said production process including the ammonolysis of sodium taurate , wherein the last mother liquor of taurine includes taurine , sodium isethionate , and impurities , comprising the following steps:(a) contacting the last mother liquor of taurine with an anion exchange resin such that taurine anion and the anion of sodium isethionate are adsorbed on the anion exchange resin;(b) eluting and regenerating the anion exchange resin with an alkali solution, and collecting the eluate;(c) subjecting the eluate to ammonia mixing treatment by adding ammonia thereto; and(d) separating the liquid in the treated eluate from impurities by solid-liquid separation in order to generate a treated mother liquor of taurine comprising taurine and sodium isethionate, and ...

Process for the preparation of Isosulfan Blue

Isosulfan blue and processes for the preparation thereof are provided. A process is also provided for preparation of the intermediate, 2-chlorobenzaldehyde-5-sulfonic acid, sodium salt of formula (2), used in the preparation thereof and a procedure for the isolation of benzaldehyde-2,5-disulfonic acid, di-sodium salt of the formula (3). Also provided is a process for the preparation of an isoleuco acid of formula (4), which upon oxidation gives rise to isosulfan blue of pharmaceutical grade which can be used for preparation of pharmaceutical formulations. The isolation and purification procedures provided in the process provide substantially pure isosulfan blue with HPLC purity 99.5% or greater. 2. The process of claim 1 , further comprising the step of recovering said isosulfan blue acid.3. The process of claim 2 , further comprising the step of purifying said recovered isosulfan blue acid.4. The process of claim 3 , wherein said purification comprises recrystallization.5. The process of claim 4 , wherein said recrystallization occurs in a solvent comprising an alcohol.6. The process of claim 5 , wherein said alcohol is aqueous isopropyl alcohol.7. The process of claim 1 , wherein said isoleuco acid is combined with said mild oxidizing agent in the absence of a strong acid.8. The process of claim 1 , wherein said mild oxidizing agent is not lead oxide claim 1 , chloranil claim 1 , or iron phthalocyanine/oxone.9. The process of claim 1 , wherein said mild oxidizing agent is silver oxide.10. The process of claim 1 , wherein combining said isoleuco acid of formula (4) with said mild oxidizing agent occurs in a polar solvent.11. The process of claim 10 , wherein said polar sol ent is selected from the group consisting of water claim 10 , alcohol claim 10 , and mixtures thereof.12. The process of claim 2 , wherein said recovery of said isosulfan blue acid occurs by precipitation from solvent.13. The process of claim 12 , wherein said solvent is an ether.14. The process ...

Method for the purification of acrylamido-2-methyl-2-propanesulphonic acid

The invention relates to a method for the purification of acrylamido-2-methyl-2-propanesulphonic acid comprising the following successive steps:1) preparation of a suspension of acrylamido-2-methyl-2-propanesulphonic acid crystals by distillation of an aqueous solution of acrylamido-2-methyl-2-propanesulphonic acid in order to obtain a suspension of acrylamido-2-methyl-2-propanesulphonic acid crystals,2) isolation of the acrylamido-2-methyl-2-propanesulphonic acid crystals generally by solid/liquid separation from said suspension in order to isolate said acrylamido-2-methyl-2-propanesulphonic acid crystals,characterised in that the distillation step is carried out continuously and at a pressure below atmospheric pressure.The invention also relates to a polymer obtained from acrylamido-2-methyl-2-propanesulphonic acid crystals or its salts, obtained according to such a method, and to the use of said polymer in oil and gas recovery, in water treatment, in sludge treatment, in manufacturing paper, in construction, in mining, in cosmetic formulation, in detergent formulation, in textile making, or in agriculture.

CYCLIC PROCESS FOR PRODUCING TAURINE

There is disclosed a process for producing taurine from ammonium isethionate by the ammonolysis of alkali isethionate in the presence of alkali ditaurinate or alkali tritaurinate, or their mixture, to inhibit the formation of byproducts and to continuously convert the byproducts of the ammonolysis reaction to alkali taurinate. Alkali taurinate is reacted with ammonium isethionate to obtain taurine and to regenerate alkali isethionate. The production yield is increased to from 90% to nearly quantitative. The ammonolysis reaction is catalyzed by alkali salts of hydroxide, sulfate, sulfite, phosphate, or carbonate. 1. A cyclic process for producing taurine from ammonium isethionate , comprising:(a) adding ammonia to a solution of a mixture of alkali isethionate, alkali ditaurinate, and alkali tritaurinate, and subjecting the solution to an ammonolysis reaction in the presence of one or a combination of two or more catalysts to yield a mixture of alkali taurinate, alkali ditaurinate, and alkali tritaurinate.(b) adding ammonium isethionate to the solution of (a) before or after removal of ammonia to yield alkali isethionate and ammonium taurinate;(c) decomposing ammonium taurinate by heating and removing ammonia from (b) to obtain a crystalline suspension of taurine in a solution of alkali isethionate, alkali ditaurinate, and alkali tritaurinate; then(d) separating taurine by means of solid-liquid separation and to provide a mother liquor containing a mixture of alkali isethionate, alkali ditaurinate, and alkali tritaurinate;(e) returning the mother liquor of (d) to (a) for further ammonolysis reaction.2. The process according to claim 1 , wherein ammonium taurinate is decomposed to taurine by heating from 75° C. to 150° C.3. The process according to claim 1 , wherein ammonia released in step (c) from the thermal decomposition of ammonium taurinate is removed from solution under reduced claim 1 , normal claim 1 , or increased pressure.4. The process according to claim 1 ...

Method for preparing oxysulphide and fluorinated derivatives in the presence of an organic solvent

The present invention concerns a method for preparing an oxysulphide and fluorinated derivative of formula (III) Ea-SO3R (III) that comprises bringing a compound of formula (II) Ea-SOOR (II)—Ea representing the fluorine atom or a group having 1 to 10 carbon atoms chosen from the fluoroalkyls, the perfluoroalkyls and the fluoroalkenyls; and—R representing hydrogen, a monovalent cation or an alkyl group; into contact, in the presence of a polar aprotic organic solvent, with an oxidising agent.

Cyclic Process for Producing Taurine from Monoethanolamine

There is disclosed a cyclic process for producing taurine from monoethanolamine comprising the steps of: (a) recovering monoethanolamine sulfate from an aqueous mother liquor solution; (b) reacting the monoethanolamine sulfate with sulfuric acid to form an aqueous solution comprised of monoethanolamine bisulfate; (c) heating the aqueous solution comprised of the monoethanolamine sulfate and optionally added monoethanolamine sulfate to yield 2-aminoethyl hydrogen sulfate ester; and (d) reacting the ester with ammonium sulfite or an alkali sulfite to yield taurine.

Fluoroalkanesulfonic Acid Production Method

Disclosed is a method for producing a fluoroalkanesulfonic acid including (1) the step of reacting concentrated sulfuric acid and/or fuming sulfuric acid with a fluoroalkanesulfonate to cause an acid decomposition, thereby obtaining a reaction mixture containing the fluoroalkanesulfonic acid and a sulfur component; and (2) the step of adding an oxidizing agent to the reaction mixture obtained by the above step and then conducting a distillation, thereby obtaining the fluoroalkanesulfonic acid from the reaction mixture. It is possible by this method to efficiently reduce the sulfur component, thereby industrially advantageously obtaining fluoroalkanesulfonic acid of high purity. 1. A method for producing a fluoroalkanesulfonic acid represented by the general formula [1] ,{'br': None, 'sup': 'f', 'sub': '3', 'RSOH\u2003\u2003[1]'}{'sup': 'f', 'sub': 1-4', '3-4, 'wherein Rrepresents a Cstraight chain or Cbranched chain fluoroalkyl group,'} {'br': None, 'sup': 'f', 'sub': 3', 'n, '(RSO)M\u2003\u2003[2]'}, '(1) the step of reacting concentrated sulfuric acid and/or fuming sulfuric acid with a fluoroalkanesulfonate represented by the general formula [2],'}, 'the method comprising{'sup': 'f', 'wherein, Ris identical with that of the general formula [1], M represents an alkali metal or an alkali earth metal, and n is an integer of 1 or 2,'} '(2) the step of adding an oxidizing agent to the reaction mixture obtained by the above step and then conducting a distillation, thereby obtaining the fluoroalkanesulfonic acid from the reaction mixture.', 'to cause an acid decomposition, thereby obtaining a reaction mixture containing the fluoroalkanesulfonic acid and a sulfur component; and'}2. A method for producing a fluoroalkanesulfonic acid represented by the formula [3] ,{'br': None, 'sub': 3', '3, 'CFSOH\u2003\u2003[3]'} {'br': None, 'sub': 3', '3', 'n, '(CFSO)M\u2003\u2003[4]'}, '(1) the step of reacting concentrated sulfuric acid and/or fuming sulfuric acid with a ...

CYCLIC PROCESS FOR PRODUCING TAURINE

There is disclosed a process for producing taurine from aziridine by (a) adding gaseous aziridine or a solution of aziridine to a solution of ammonium bisulfite, or ammonium sulfite, or a mixture of ammonium bisulfite and ammonium sulfite to form ammonium taurinate; (b) decomposing ammonium taurinate by heating and removing ammonia from (a) to obtain a crystalline suspension of taurine; and (c) separating taurine by means of solid-liquid separation. 1. A process for producing taurine from aziridine , comprising:(a) adding gaseous aziridine or a solution of aziridine to a solution of ammonium bisulfite, or ammonium sulfite, or a mixture of ammonium bisulfite and ammonium sulfite to undergo a ring-opening reaction of aziridine to form ammonium taurinate;(b) decomposing ammonium taurinate to taurine and ammonia by heating and removing ammonia to obtain a crystalline suspension of taurine; and(c) separating taurine by means of solid-liquid separation to provide a mother liquor.2. The process according to claim 1 , wherein aziridine is prepared by gaseous dehydration of monoethanolamine.3. The process according to claim 1 , wherein aziridine is prepared by alkali hydroxide treatment of 2-aminoethyisulfonate ester.4. The process according to claim 1 , wherein aziridine is prepared by ammonolysis of 1 claim 1 ,2-dichloroethane.5. The process according to claim 3 , wherein alkali hydroxide is selected from lithium hydroxide claim 3 , sodium hydroxide claim 3 , potassium hydroxide claim 3 , and cesium hydroxide.6. The process according to claim 1 , wherein the mother liquor is combined with ammonium bisulfite claim 1 , or ammonium sulfite claim 1 , or a mixture of ammonium bisulfite and ammonium sulfite to prepare a solution to react with aziridine.7. The process according to claim 1 , wherein the mother liquor is used to absorb ammonia and sulfur dioxide to prepare a solution of ammonium bisulfite claim 1 , ammonium sulfite claim 1 , or a mixture of ammonium bisulfite and ...

Integrated processing system with continuous acid loop for converting methane to methane-sulfonic acid

Methods and machinery are described for combining methane with sulfur trioxide to make MSA, in a system that sustains optimal concentrations of reactants in the main reactor for high yields, efficiency, and profitability. Rather than simply making MSA and then removing it, this design uses a “continuous loop system” with: (i) a “rich acid” stream containing a high concentration of MSA, mixed with sulfuric acid, which will emerge from the main reactor, and (ii) a “reduced acid” stream containing a low concentration of MSA (still mixed with sulfuric acid), from an extractor unit (such as a distillation unit) which removes some but not all of the MSA from the “rich acid”. Additional subassemblies are described which enable the main reactor to work efficiently, at a sustained high flow-through capacity. This system also can be scaled up or down, for any daily MSA production rate.

CYCLIC PROCESS FOR PRODUCING ALKALI TAURINATE

There is disclosed a cyclic process for producing alkali taurinate from a solution comprising alkali ditaurinate and alkali tritaurinate by the ammonolysis in the presence of one or more catalysts. The ammonolysis reaction is catalyzed by alkali salts of hydroxide, sulfate, sulfite, phosphate, or carbonate. Taurine or alkali taurinate is prepared in a yield from 90% to quantitative by successive ammonolysis. 1. A cyclic process for producing alkali taurinate , comprising:(a) adding an excess of ammonia and at least one catalyst to a solution comprising alkali ditaurinate and alkali tritaurinate;(b) subjecting the solution of step (a) to an ammonolysis reaction; and(c) removing excess ammonia to obtain a solution comprising alkali taurinate.2. The cyclic process according to claim 1 , further comprising the steps of:(d) neutralizing the strongly basic solution comprising alkali taurinate with an acid to form a neutralized solution containing a crystalline suspension of taurine, wherein the neutralized solution has a pH of 5-9;(e) separating the taurine from the neutralized solution;(f) returning the neutralized solution of step (e) to step (a) for further ammonolysis.3. The process according to claim 1 , wherein the solution comprising alkali ditaurinate and alkali tritaurinate is prepared from diethanolamine and triethanolamine.4. The process according to claim 1 , wherein the solution comprising alkali ditaurinate and alkali tritaurinate is the neutralized solution after separating taurine in the production of taurine by a prior ammonolysis reaction of alkali isethionate.5. The process according to claim 1 , wherein the solution comprising alkali ditaurinate and alkali tritaurinate is the neutralized solution after separating taurine in the production of taurine by a prior ammonolysis reaction of the solution comprising alkali ditaurinate and alkali tritaurinate.6. The process according to claim 1 , wherein the at least one catalyst is selected from the group of ...

AGOMELATINE SULFURIC ACID COMPLEX, AND PREPARATION METHOD AND APPLICATION THEREOF

The present invention relates to an Agomelatine sulfuric acid complex in formula (I) and the preparation method thereof (HX=HSO, RSOH (R=CH, Ph, 4-CHPh)). The solubility of the Agomelatine sulfuric acid complex obtained by the method of the present invention is significantly improved compared with Agomelatine, has good stability and higher purity, and is suitable for application in finished-product medicinal preparations. The preparation process is quite simple, and a product with high purity can be obtained without special operations. 3. The Agomelatine benzenesulfonic acid complex according to claim 2 , wherein when R is Ph claim 2 , the crystal belongs to a orthorhombic crystal system as determined by single crystal X-diffraction claim 2 , with a space group of P212121 claim 2 , cell parameters: a=8.0780(5)Å claim 2 , b=8.5765(6)Å claim 2 , c=28.920(2)Å claim 2 , α=β=γ=90.0° claim 2 , cell volume V=2003.6(2)Å3 claim 2 , and the number of asymmetric units in the cell Z=4.4. A method for preparing the Agomelatine sulfuric acid complex according to claim 1 , comprising forming a complex by reaction between the Agomelatine and the corresponding acid HX.5. The method for preparing the Agomelatine sulfuric acid complex according to claim 1 , comprising forming a complex by reaction between the Agomelatine and the corresponding acid in an organic solvent.6. The method for preparing the Agomelatine sulfuric acid complex according to claim 4 , comprising dissolving Agomelatine into an organic solvent before adding a corresponding acid claim 4 , and separating the crystal or precipitate out during the reaction as a product.7. The method for preparing the Agomelatine sulfuric acid complex according to claim 4 , comprising dissolving Agomelatine into an organic solvent before adding a corresponding acid claim 4 , and then adding another poor solvent; separating the crystal or precipitate out during the reaction as a product.8. The method for preparing the Agomelatine ...

PROCESS FOR PRODUCING TAURINE

There is disclosed a process for producing taurine by reacting 2-oxazolidinone with ammonium sulfite, or ammonium bisulfite, or a mixture of ammonium sulfite and ammonium bisulfite in an aqueous solution to form ammonium taurinate and ammonium bicarbonate. Taurine is obtained by decomposing ammonium taurinate to taurine and ammonia and recovered by solid-liquid separation. 1. A process for producing taurine from 2-oxazolidinone , comprising:(a) reacting 2-oxazolidinone with ammonium sulfite, or ammonium bisulfite, or a mixture of ammonium sulfite and ammonium bisulfite in an aqueous solution to form ammonium taurinate and ammonium bicarbonate;(b) decomposing ammonium taurinate and ammonium bicarbonate to taurine, ammonia, and carbon dioxide by heating and removing ammonia and carbon dioxide to obtain a crystalline suspension of taurine; and(c) separating taurine by means of solid-liquid separation.2. The process according to claim 1 , wherein the molar ratio of 2-oxazolidinone to ammonium sulfite or bisulfite is from 0.9 to 10.3. The process according to claim 1 , wherein the molar ratio of 2-oxazolidinone to ammonium sulfite or bisulfite is from 1.0 to 2.0.4. The process according to claim 1 , wherein the molar ratio of 2-oxazolidinone to ammonium sulfite or bisulfite is from 1.0 to 1.2.5. The process according to claim 1 , wherein the reaction of 2-oxazolidinone with ammonium sulfite or bisulfite is carried out in a pH range from 5.0 to 9.0.6. The process according to claim 1 , wherein the reaction of 2-oxazolidinone with ammonium sulfite or bisulfite is carried out in a pH range from 6.0 to 8.0.7. The process according to claim 1 , wherein the reaction of 2-oxazolidinone with ammonium sulfite or bisulfite is carried out at a temperature from 60° C. to 160° C.8. The process according to claim 1 , wherein the reaction of 2-oxazolidinone with ammonium sulfite or bisulfite is carried out at a temperature from 90° C. to 120° C.9. The process according to claim 1 , ...

PROCESS FOR PRODUCING ALKALI TAURINATE

There is disclosed a process for producing alkali taurinate from alkali isethionate by the ammonolysis of a solution of alkali isethionate, alkali ditaurinate, and alkali tritaurinate, or a solution of alkali ditaurinate and alkali tritaurinate. The overall yield of alkali taurinate from alkali isethionate is obtained to from 90% to nearly quantitative. The ammonolysis reaction is catalyzed by alkali salts of hydroxide, sulfate, sulfite, phosphate, or carbonate. 1. A process for producing alkali taurinate from alkali isethionate , comprising:(a) adding an excess of ammonia and one or more catalysts to a solution of alkali isethionate, alkali ditaurinate, and alkali tritaurinate, or to a solution of alkali ditaurinate and alkali tritaurinate;(b) subjecting the solution of step (a) to an ammonolysis reaction; and(c) removing excess ammonia to yield a mixture of alkali taurinate, alkali ditaurinate, and alkali tritaurinate.2. The process according to claim 1 , wherein alkali ditaurinate and alkali tritaurinate are produced by a process which comprises an ammonolysis reaction of alkali isethionate to alkali taurinate claim 1 , alkali ditaurinate claim 1 , and alkali tritaurinate.3. The process according to claim 1 , wherein the solution of alkali ditaurinate and alkali tritaurinate is the mother liquor of taurine crystallization.4. The process according to claim 1 , wherein the solution of alkali isethionate claim 1 , alkali ditaurinate claim 1 , and alkali tritaurinate is prepared by mixing alkali isethionate with the solution of alkali ditaurinate and alkali tritaurinate.5. The process according to claim 1 , one or a combination of two or more catalysts for the ammonolysis reaction is selected from alkali salts of hydroxide claim 1 , carbonate claim 1 , sulfate claim 1 , sulfite claim 1 , phosphate claim 1 , and nitrate.6. The process according to claim 1 , wherein the catalysts for the ammonolysis reaction are selected from alkali salts of hydroxide.7. The process ...

PROCESS FOR PRODUCING ALKALI TAURINATE

There is disclosed a process for producing alkali taurinate from alkali isethionate, alkali ditaurinate, or alkali tritaurinate by adding excess ammonia and at least of equal molar amount of an alkali hydroxide to a solution comprised of alkali ditaurinate, alkali tritaurinate, or their mixture and subjecting the solution to an ammonolysis to yield a solution comprised of alkali taurinate. 1. A process for producing alkali taurinate from a solution comprised of alkali ditaurinate in a molar yield of at least 70% on the basis of alkali ditaurinate , comprising:(a) adding an alkali hydroxide and excess ammonia to a solution comprised of alkali ditaurinate, wherein the molar amount of alkali hydroxide is at least equal to the molar amount of sodium ditaurinate and wherein the alkali is lithium, sodium, or potassium; and(b) subjecting the solution of step (a) to an ammonolysis to yield a solution comprised of alkali taurinate.2. A process for producing alkali taurinate from a solution comprised of alkali tritaurinate in a molar yield of at least 70% on the basis of alkali tritaurinate , comprising:(a) adding an alkali hydroxide and excess ammonia to a solution comprised of alkali tritaurinate, wherein the molar amount of alkali hydroxide is at least equal to the molar amount of sodium tritaurinate and wherein the alkali is lithium, sodium, or potassium; and(b) subjecting the solution of step (b) to an ammonolysis to yield a solution comprised of alkali taurinate.3. A process for producing alkali taurinate from a solution comprised of alkali ditaurinate and alkali tritaurinate in a molar yield of at least 70% on the basis of total molar amount of alkali ditaurinate and alkali tritaurinate , comprising:(a) adding an alkali hydroxide and excess ammonia to a solution comprised of alkali ditaurinate and alkali tritaurinate, wherein the molar amount of alkali hydroxide is at least equal to the total molar amount of sodium ditaurinate and sodium tritaurinate and wherein the ...

Process for the preparation of Isosulfan Blue

Isosulfan blue and processes for the preparation thereof are provided. A process is also provided for preparation of the intermediate, 2-chlorobenzaldehyde-5-sulfonic acid, sodium salt of formula (2), used in the preparation thereof and a procedure for the isolation of benzaldehyde-2, 5-disulfonic acid, di-sodium salt of the formula (3). Also provided is a process for the preparation of an isoleuco acid of formula (4), which upon oxidation gives rise to isosulfan blue of pharmaceutical grade which can be used for preparation of pharmaceutical formulations. The isolation and purification procedures provided in the process provide substantially pure isosulfan blue with HPLC purity 99.5% or greater. 2. The process of claim 1 , wherein combining said isoleuco acid of formula (4) with said oxidizing agent occurs in a polar solvent.3. The process of claim 2 , wherein said polar solvent is selected from the group consisting of water claim 2 , alcohol claim 2 , and mixtures thereof.4. The process of claim 2 , wherein said polar solvent is methanol.5. The process of claim 1 , wherein said oxidizing agent is silver oxide.6. The process of claim 1 , wherein said process of obtaining an isosulfan blue sodium salt comprises combining said isosulfan blue acid with a sodium solution.7. The process of claim 6 , wherein said sodium solution is an aqueous sodium solution.8. The process of claim 1 , wherein said isosulfan blue sodium salt is obtained in a purity of at least 99% as measured by HPLC.9. The process of claim 9 , wherein said isosulfan blue sodium salt is obtained in a purity of at least 99.5% as measured by HPLC.11. The process of claim 10 , wherein combining said isoleuco acid of formula (4) with said oxidizing agent occurs in a polar solvent.12. The process of claim 11 , wherein said polar solvent is selected from the group consisting of water claim 11 , alcohol claim 11 , and mixtures thereof.13. The process of claim 11 , wherein said polar solvent is methanol.14. The ...

Cyclic process for the production of taurine from monoethanolamine

A method is disclosed for the production of taurine in high yield by a cyclic process of reacting monoethanolamine, sulfuric acid, and ammonium sulfite in the presence of additives to inhibit the hydrolysis of 2-aminoethyl hydrogen sulfate intermediate. The cyclic process is economical and little waste is generated. 1. (canceled)2. (canceled)3. (canceled)4. (canceled)5. (canceled)6. (canceled)7. (canceled)8. A cyclic process for increasing the overall production yield of taurine from monoethanolamine , comprising:(a) Carrying out the reaction of 2-aminoethyl hydrogen sulfate with ammonium sulfite to yield taurine in a buffering system at pH 6.0 to 8.0.(b) Suppressing the hydrolysis of 2-aminoethyl hydrogen sulfate ester during its reaction with ammonium sulfite by use of hydrolysis inhibitors.(c) Converting the residual monoethanolamine in the crystallization mother liquor of taurine to 2-aminoethyl hydrogen sulfate ester, which is recycled to step (a) to produce taurine.9. The process according to claim 8 , wherein the overall production yield is greater than 95%.10. The process according to (a) claim 8 , wherein the buffering system is composed of ammonium bisulfite and excess ammonium sulfite.11. The process according to (b) claim 8 , wherein hydrolysis inhibitors are monoethanolamine claim 8 , diethanolamine claim 8 , triethanolamine claim 8 , and dimethylaminoethanol.12. The process according to (c) claim 8 , wherein the residual monoethanolamine in the crystallization mother liquor of taurine is reacted with sulfuric acid in the presence of ammonium sulfate to regenerate 2-aminoethyl hydrogen sulfate ester intermediate. This invention relates to a cyclic process for preparing taurine from monoethanolamine by way of 2-aminoethyl hydrogen sulfate intermediate in high yield which is economical and in which little waste is generated.Taurine can be referred to as 2-aminoethanesulfonic acid and is of the formula HNCHCHSOH. Taurine is an extremely useful compound ...

Process for the preparation of Isosulfan Blue

Isosulfan blue and processes for the preparation thereof are provided. A process is also provided for preparation of the intermediate, 2-chlorobenzaldehyde-5-sulfonic acid, sodium salt of formula (2), used in the preparation thereof and a procedure for the isolation of benzaldehyde-2, 5-disulfonic acid, di-sodium salt of the formula (3). Also provided is a process for the preparation of an isoleuco acid of formula (4), which upon oxidation gives rise to isosulfan blue of pharmaceutical grade which can be used for preparation of pharmaceutical formulations. The isolation and purification procedures provided in the process provide substantially pure isosulfan blue with HPLC purity 99.5% or greater. 2. The process of claim 1 , further comprising the step of recovering said isosulfan blue acid.3. The process of claim 2 , further comprising the step of purifying said recovered isosulfan blue acid.4. The process of claim 3 , wherein said purification comprises recrystallization.5. The process of claim 4 , wherein said recrystallization occurs in a solvent comprising an alcohol.6. The process of claim 5 , wherein said alcohol is aqueous isopropyl alcohol.7. The process of claim 1 , wherein said isoleuco acid is combined with said mild oxidizing agent in the absence of a strong acid.8. The process of claim 1 , wherein said mild oxidizing agent is not lead oxide claim 1 , chloranil claim 1 , or iron phthalocyanine/oxone.9. The process of claim 1 , wherein said mild oxidizing agent is silver oxide.10. The process of claim 1 , wherein combining said isoleuco acid of formula (4) with said mild oxidizing agent occurs in a polar solvent.11. The process of claim 10 , wherein said polar solvent is selected from the group consisting of water claim 10 , alcohol claim 10 , and mixtures thereof.12. The process of claim 2 , wherein said recovery of said isosulfan blue acid occurs by precipitation from solvent.13. The process of claim 12 , wherein said solvent is an ether.14. The process ...

Process For Producing Taurine

There is disclosed a process for producing taurine by subjecting an ammonia solution ammonium isethionate in the presence of a hydrogenation catalyst and hydrogen to an ammonolysis reaction to form ammonium taurinate. Taurine is obtained by decomposing ammonium taurinate to taurine and ammonia and recovered by solid-liquid separation. 1. A process for producing taurine from ammonium isethionate , comprising:(a) preparing an ammonia solution comprising ammonium isethionate and at least one hydrogenation catalyst;(b) subjecting the ammonia solution to an ammonolysis reaction in the presence of hydrogen or at least one hydrogen donor to yield a solution comprising ammonium taurinate;(c) removing ammonia and decomposing the ammonium taurinate to taurine by heating to obtain a crystalline suspension of taurine; and(d) separating the taurine by means of a solid-liquid separation to obtain a mother liquor.2. The process according to claim 1 , wherein the mother liquor after the separation of the taurine is mixed the ammonia solution prepared in step (a).3. The process according to claim 1 , the hydrogenation catalyst is selected from the group of catalysts based on nickel claim 1 , cobalt claim 1 , copper claim 1 , platinum claim 1 , palladium claim 1 , ruthenium claim 1 , rhodium claim 1 , osmium claim 1 , iridium claim 1 , rhenium claim 1 , and a mixture of at least two thereof.4. The process according to claim 1 , the hydrogenation catalyst is selected from Raney nickel claim 1 , Raney copper claim 1 , Pd/C claim 1 , or Ru/C.5. The process according to claim 1 , the hydrogen donor is selected from formic acid or a secondary alcohol. This application is a divisional application of U.S. patent application Ser. No. 16/201,524, filed Nov. 27, 2018, which is a continuation-in-part of U.S. patent application Ser. No. 15/894,382, filed Feb. 12, 2018, now abandoned, which is a continuation-in-part of U.S. patent application Ser. No. 15/832,667, filed Dec. 5, 2017, now U.S. Pat. ...

SULFONIUM SALT-CONTAINING POLYMER, RESIST COMPOSITION, PATTERNING PROCESS, AND SULFONIUM SALT MONOMER AND MAKING METHOD

A sulfonium salt having a 4-fluorophenyl group is introduced as recurring units into a polymer comprising hydroxyphenyl(meth)acrylate units and acid labile group-containing (meth)acrylate units to form a polymer which is useful as a base resin in a resist composition. The resist composition has a high sensitivity, high resolution and minimized LER. The present application is a 37 C.F.R. §1.53(b) divisional of, and claims priority to, U.S. application Ser. No. 13/292,127, filed Nov. 9, 2011. Priority is also claimed to Japanese Application No. 2010-258496 filed on Nov. 19, 2010. The entire contents of each of these applications is hereby incorporated by reference.This invention relates to (1) a polymerizable sulfonium salt comprising a fluorinated sulfonium cation and an anion having a polymerizable unit, (2) a polymer comprising units of the sulfonium salt, (3) a resist composition comprising the polymer, and (4) a process for patterning the resist composition using high-energy radiation.While a number of recent efforts are being made to achieve a finer pattern rule in the drive for higher integration densities and operating speeds in LSI devices, DUV and EUV lithography is thought to hold particular promise as the next generation in microfabrication technology. In particular, photolithography using an ArF excimer laser as the light source is thought requisite to the micropatterning technique capable of achieving a feature size of 0.13 μm or less.The lithography techniques which are considered promising next to the ArF lithography include electron beam (EB) lithography, Flithography, extreme ultraviolet (EUV) lithography, and x-ray lithography. In these techniques, exposure must be done in vacuum or reduced pressure, which allows the sulfonic acid generated during exposure to volatilize, failing to form a satisfactory pattern profile. The sulfonic acid volatilized can damage the exposure system. In the EB and EUV lithography, it is desired to make a resist material ...

HYDROPHILIC OIL REPELLENT AND PRODUCTION METHOD OF SAME, SURFACE COATING MATERIAL, COATING FILM, RESIN COMPOSITION, OIL-WATER SEPARATION FILTER MATERIAL, AND POROUS BODY

The hydrophilic oil repellent includes one or more types of nitrogen-containing fluorine-based compounds. The nitrogen-containing fluorine-based compound includes any one hydrophilicity imparting group selected from the group consisting of anion type hydrophilicity imparting groups, cation type hydrophilicity imparting groups, and amphoteric type hydrophilicity imparting groups in the molecule. 2. The hydrophilic oil repellent according to claim 1 ,{'sub': 2', '3', '3', '2', '3', '2', '2', '2', 'y', '2-y, 'sup': 1', '1', '1', '1', '1', '1', '1', '1', '1', '2', '3', '4', '+', '1', '4, 'wherein, in the above formulas (1) to (4), X is an anion type hydrophilic imparting group having “—COM”, “—SOM”, “—OSOM”, “—OP(OH)OM”, “—OPOM”, “═OPOM”, or “—PO(OH)(OM)” (Mrepresents an alkali metal, an alkali earth metal, Mg, Al, or RRRRN; Rto Rare each independently a hydrogen atom or a linear or branched alkyl group having 1 to 20 carbon atoms, and y represents an integer of 0 to 2) at a terminal.'}3. The hydrophilic oil repellent according to claim 1 ,{'sup': +', '5', '6', '7', '−', '+', '5', '6', '7', '−', '+', '5', '6', '7', '−', '+', '5', '6', '7', '−', '+', '5', '6', '7', '7', '−', '+', '5', '6', '7', '+', '5', '6', '7', '2−', '+', '5', '6', '7', '2−', '5', '7, 'sub': 3', '3', '4', '3', '2', '3', '2', '4, 'wherein, in the above formulas (1) to (4), X is a cation type hydrophilicity imparting group having “—NRRR.Cl”, “—NRRR.Br”, “—NRRR.I”, “—NRRR.CHSO”, “—NRRR.RSO”, “—NRRR.NO”, “(—NRRR)CO”, or “(—NRRR)SO” (Rto Rare hydrogen atoms or each independently a linear or branched alkyl group having 1 to 20 carbon atoms) at a terminal.'}4. The hydrophilic oil repellent according to claim 1 ,wherein, in the above formulas (1) to (4), X is an amphoteric hydrophilicity imparting group having any one terminal of a carboxybetaine type, a sulfobetaine type, an amine oxide type, and a phosphobetaine type.6. A surface coating material claim 1 , comprising:{'claim-ref': {'@idref': 'CLM-00001', ' ...

A process for producing taurine

The present application provides a process for preducing taurine, comprising the steps as follows: (a) mixing isethionic acid with taurine salt solution until the system pH reaches a certain value in a range from 5.0 to 9.5; (b) separating liquid phase and solid phase of the system; wherein said solid phase is the crude product of taurine, and said liquid phase is isethionate solution; (c) reacting ammonia solution with said liquid phase obtained from step (b) to obtain taurine salt solution. It uses isethionic acid to adjust the pH of the taurine salt solution, avoiding the problem causing by using sulphate acid to adjust the pH in the traditional process. By the recycling use of the cations in taurine salts, a new raw material or reagent does not need to be added which is benefit to reducing the use of dangerous chemical materials, simplifying the production process greatly, improving the utilization rate of raw materials, increasing the yield of the product and decreasing production cost significantly.

Method for preparing oxysulphide and fluorinated derivatives by sulphination

The invention concerns a method for preparing an oxysulphide and fluorinated derivative, said method comprising the reacting, in the presence of an organic solvent, of: i) at least one compound of formula Ea-COOR (I), in which Ea represents the fluorine atom or a group having 1 to 10 carbon atoms chosen from fluoroalkyls, perfluoroalkyls and fluoroalkenyls and R represents hydrogen, a monovalent cation or an alkyl group, and ii) a sulphur oxide, said method being such that the initial molar ratio (sulphur oxide/compound of formula (I)) is less than 0.4 and the concentration of sulphur oxide dissolved in the reaction medium is kept constant for the entire duration of the reaction to a value of between 0.2% and 3% by weight by means of continually adding said sulphur oxide to the reaction medium.

METHOD OF DETECTION OF AMINO ACID SEQUENCE AND/OR IDENTIFICATION OF PEPTIDES AND PROTEINS, BY USE OF A NEW DERIVATIZATION REAGENT AND SYNTHESIS OF 5-FORMYL-BENZENE-1,3-DISULPHONIC ACID AS DERIVATIZATION REAGENT

Present invention refers to a novel and improved method of derivatization and detection of amino acid sequence and/or identification of proteins, peptides by a new derivatization compound. Precisely, the method discloses a novel approach to derivatization of peptides or proteins by compounds comprising two or more sulfonyl groups and analysis of derivatized analytes in negative mode of operation of mass spectrometer. This method allows unambiguous analysis of amino acid sequence of long-chain peptides/proteins. Also, the invention discloses a novel synthesis procedure of 5-formyl-benzene-1,3-disulphonic acid as derivatization compound. 2. The method according to claim 1 , comprising the reactive group of derivatization compound is selected from the group comprising aldehyde- claim 1 , keto- claim 1 , isothiocyanate- claim 1 , isocyanate-group claim 1 , NHS ester claim 1 , anhydride or activated carboxylic acid group.3. The method according to claim 1 , comprising the reactive group of derivatization compound is aldehyde group.4. The method according to claim 1 , comprising the derivatization compound is 5-formylbenzene-1 claim 1 ,3-disulphonic acid.5. The method according to comprising the derivatization step is carried out at pH 1-5.6. The method according to comprising the derivatization step is carried out with the addition of NaCNBH.71. The method according to claim from comprising in the analysis step the spectrum of derivatized b-negative ions is acquired in negative mode of operation of mass spectrometer.8. A method of synthesis of 5-formyl-benzene-1 claim 3 ,3-disulphonic acid claim 3 , comprising it comprises the following steps:conversion of 3,5-dihydroxybenzaldehyde into O-benzaldehyde-3,5-bis(N,N-dimethylthiocarbamate) by use of relevant N,N-dialkylcarbamoylchloride with organic or inorganic bases in suitable organic solvent;rearrangement of O-benzaldehyde-3,5-bis(N,N-dimethylthiocarbamate) to obtain S-benzaldehyde-3,5-bis(N,N-dimethylthiocarbamate); ...

Process for the preparation of Isosulfan Blue

Isosulfan blue and processes for the preparation thereof are provided. A process is also provided for preparation of the intermediate, 2-chlorobenzaldehyde-5-sulfonic acid, sodium salt of formula (2), used in the preparation thereof and a procedure for the isolation of benzaldehyde-2,5-disulfonic acid, di-sodium salt of the formula (3). Also provided is a process for the preparation of an isoleuco acid of formula (4), which upon oxidation gives rise to isosulfan blue of pharmaceutical grade which can be used for preparation of pharmaceutical formulations. The isolation and purification procedures provided in the process provide substantially pure isosulfan blue with HPLC purity 99.5% or greater. 1. A compound isosulfan blue acid or a pharmaceutically acceptable salt thereof having a purity of at least 99.0% by HPLC.2. The compound according to having less than 20 ppm silver.3. The compound according to having a purity between 99.0% and 99.5% by HPLC.4. The compound according to having a purity greater than 99.5% by HPLC.5. The compound according to having less than 20 ppm silver.6. A pharmaceutical formulation comprising the compound of and a pharmaceutically acceptable excipient wherein the pharmaceutical formulation is a solution suitable for parenteral use.7. The pharmaceutical formulation of claim 6 , wherein the solution is an aqueous solution.8. The pharmaceutical formulation of claim 6 , wherein the pharmaceutical formulation contains between 0.5% and 1% impurities by HPLC.9. The pharmaceutical formulation of claim 6 , wherein the pharmaceutical formulation contains less than about 0.5% impurities by HPLC.10. The pharmaceutical formulation of claim 6 , wherein the pharmaceutical formulation contains less than 20 ppm silver.12. The process according to claim 11 , wherein the process is a bulk scale process.13. The process according to claim 11 , wherein the process is a large-scale cGMP process. This is a continuation application, and claims the benefit, of U. ...

Process for Manufacturing Haloaryl Compounds From Mixtures of Isomers of Dihalodiarylsulfone

A process for the manufacture of a haloaryl compound which comprises contacting a mixture of dihalodiarylsulfone isomers [mixture (M)] with sulfuric acid to provide a mixture of haloarylsulfonic acid isomers [mixture (M1)] and reacting mixture (M1) in the presence of water. The process is independent on the manufacturing process of mixture (M) and is advantageous in that the obtained haloaryl compound can be recycled to the first step of a dihalodiarylsulfone manufacturing process.

METHODS FOR PRODUCING ALKYLBENZENES, PARAFFINS, OLEFINS AND OXO ALCOHOLS FROM WASTE PLASTIC FEEDSTOCKS

The present invention relates generally to methods for producing detergent compounds from waste plastic feedstocks. More specifically, the invention relates to methods for producing detergent intermediates, including alkylbenzenes, paraffins, olefins, oxo alcohols, and surfactant derivatives thereof from waste plastic feedstock. 1. A method for producing paraffin from waste plastic feedstock and kerosene and/or another source(s) of hydrocarbons comprising the steps of:providing a first feed stream comprising kerosene and/or another source(s) of hydrocarbons;pre-fractionating the first feed stream to produce a first heart cut paraffin stream comprising paraffins in a heart cut range;hydrotreating a second feed stream comprising waste plastic feedstock;combining the first heart cut paraffin stream with the hydrotreated second feed stream to form a combined stream;hydrotreating the combined stream; andfractionating the hydrotreated combined stream to remove paraffins that are heavier and/or lighter than the heart cut range to form a second heart cut paraffin stream.2. The method according to claim 1 , wherein the first heart cut paraffin stream comprises C10-C13 hydrocarbons.3. A method for producing paraffin from waste plastic feedstock comprising the steps of: providing a feed stream comprising waste plastic feedstock;pre-fractionating the feed stream comprising waste plastic feedstock to produce a first heart cut paraffin stream comprising paraffins in a heart cut range;hydrotreating the first heart cut paraffin stream;fractionating the hydrotreated feed stream to remove paraffins that are heavier and/or lighter than a heart cut range to form a second heart cut paraffin stream.4. The method according to claim 3 , further comprising the step of separating branched and cyclic hydrocarbons from the second heart cut paraffin stream to form a linear heart cut paraffin stream. The present invention relates generally to methods for producing detergent compounds from waste ...

Linear alkylbenzenes from natural oils and methods of producing

A linear alkyl benzene product and production of linear alkylbenzene from a natural oil are provided. A method comprises the step of deoxygenating the natural oils to form a stream comprising paraffins. The paraffins are dehydrogenated to provide mono-olefins. Then, benzene is alkylated with the mono-olefins under alkylation conditions to provide an alkylation effluent comprising alkylbenzenes and benzene. Thereafter, the alkylbenzenes are isolated to provide the alkylbenzene product.

VINYLIDENE DIMER DERIVATIVES

The present invention provides a process for producing vinylidene dimer derivatives, which process includes subjecting one or more vinylidene dimers to an epoxidation reaction to obtain a vinylidene-derived epoxide. 1. A process for producing vinylidene dimer derivatives , which process includes subjecting one or more vinylidene dimers to an epoxidation reaction to obtain a vinylidene-derived epoxide.2. The process of claim 1 , wherein the one or more vinylidene dimers are epoxidated with hydrogen peroxide.3. The process of claim 1 , wherein the vinylidene-derived epoxide is subsequently reacted with sodium hydrogen sulfite to produce a vinylidene-derived β-hydroxysulfonic acid.4. The process of claim 1 , wherein the vinylidene-derived epoxide is subsequently reacted with water to produce a vinylidene-derived glycol.5. The process of claim 1 , wherein the vinylidene-derived epoxide is subsequently reacted with an acid to produce a vinylidene-derived aldehyde.6. The process of claim 1 , wherein the vinylidene-derived epoxide is subsequently catalytically hydrogenated with water to produce a vinylidene-derived Guerbet alcohol.7. The process of claim 1 , wherein the vinylidene-derived epoxide is subsequently reacted with polyethylene glycol to produce a vinylidene-derived ethoxylate.8. The process of claim 1 , wherein the vinylidene-derived epoxide is subsequently reacted with at least one of ammonia claim 1 , diethanolamine claim 1 , trimethylamine claim 1 , and ethylene diamine.9. A process for producing vinylidene dimer derivatives claim 1 , which process includes subjecting one or more vinylidene dimers to a sulfonation reaction to obtain a vinylidene-derived β claim 1 ,γ-unsaturated sulfonic acid.10. A process for producing vinylidene dimer derivatives claim 1 , which process includes subjecting one or more vinylidene dimers to an alkylation reaction with an aromatic compound to obtain a vinylidene-derived di-substituted aromatic compound.11. A process for ...

Cyclic process for the production of taurine from alkali isethionate and alkali vinyl sulfonate

The present invention discloses a cyclic process for the production of taurine from alkali isethionate and alkali vinyl sulfonate in a high overall yield of greater than 95% by continuously converting the byproducts of the ammonolysis reaction, sodium ditaurinate and sodium tritaurinate, to sodium taurinate. Pure sodium ditaurinate and sodium tritaurinate are prepared from diethanolamine and triethanolamine as starting materials, respectively, and are subjected to the ammonolysis reaction to yield a mixture of sodium taurinate, sodium ditaurinate, and sodium tritaurinate. 1. (canceled)2. A process for the production of taurine from alkali ditaurinate , alkali tritaurinate , and their mixture , comprising ,(a) Adding an excess amount of ammonia to a solution of alkali ditaurinate and alkali tritaurinate and subjecting the solution to ammonolysis reaction to yield a mixture of alkali taurinates in the presence of catalysts;(b) Removing excess ammonia from (a) and neutralizing alkali taurinates with an acid to form a crystalline suspension of taurine.(c) Recovering taurine by means of solid-liquid separation.3. (canceled)4. (canceled)5. (canceled)6. (canceled)7. (canceled)8. (canceled)9. The process according to claim 2 , wherein alkali ditaurinate and alkali tritaurinate are prepared from diethanolamine and triethanolamine claim 2 , respectively.10. The process according to claim 2 , wherein alkali ditaurinate claim 2 , alkali tritaurinate claim 2 , and their mixture are the byproducts in the production of taurine by the ammonolysis reaction of alkali isethionate and alkali vinyl sulfonate.11. The process according to claim 2 , wherein the catalysts are sodium hydroxide claim 2 , potassium hydroxide claim 2 , lithium hydroxide claim 2 , sodium carbonate claim 2 , potassium carbonate claim 2 , lithium carbonate claim 2 , sodium sulfate claim 2 , sodium sulfite claim 2 , potassium sulfate claim 2 , and potassium sulfite.12. (canceled)13. (canceled)14. (canceled)15. The ...

Cyclic process for the production of taurine from alkali isethionate and alkali vinyl sulfonate

The present invention discloses a cyclic process for the production of taurine from alkali isethionate and alkali vinyl sulfonate in a high overall yield of greater than 95% by continuously converting the byproducts of the ammonolysis reaction, sodium ditaurinate and sodium tritaurinate, to sodium taurinate. Sodium sulfate and residual taurine in the crystallization mother liquor are efficiently separated by converting taurine into a highly soluble form of sodium taurinate or ammonium taurinate while selectively crystallizing sodium sulfate. 1. A cyclic process for the production of taurine from alkali isethionate and from alkali vinyl sulfonate in high yield , comprising ,(a) Adding an excess of ammonia to a solution of alkali isethionate or alkali vinyl sulfonate and subjecting the solution to ammonolysis reaction in the presence of catalysts to yield a mixture of alkali taurinate, alkali ditaurinate, alkali tritaurinate, and unreacted alkali isethionate;(b) Recovering the excess ammonia from (a) and neutralizing the solution with sulfuric acid to obtain a crystalline suspension of taurine in a solution of alkali sulfate, alkali ditaurinate, alkali tritaurinate, and alkali isethionate;(c) Separating taurine from (b) by filtration;(d) Separating alkali sulfate from the mother liquor of (c) by evaporative crystallization and filtration;(e) Returning most of the mother liquor of (d) to (a) for further ammonolysis of alkali ditaurinate, alkali tritaurinate, and unreacted alkali isethionate.2. The process according to claim 1 , wherein the overall yield is greater than 85%.3. (canceled)4. (canceled)5. The process according to claim 1 , wherein the mother liquor is mixed with a new batch of alkali isethionate or alkali vinyl sulfonate.6. The process according to claim 1 , wherein the catalysts are sodium hydroxide claim 1 , potassium hydroxide claim 1 , lithium hydroxide claim 1 , sodium carbonate claim 1 , potassium carbonate claim 1 , lithium carbonate claim 1 , ...

Process For The Production Of Lignin Derived Low Molecular Products

The present invention relates to novel lignin-derived compounds and compositions comprising the same and their use as redox flow battery electrolytes. The invention further provides a method for preparing said compounds and compositions as well as a redox flow battery comprising said compounds and compositions. Additionally, an assembly for carrying out the inventive method is provided. 2. The sulfonated low molecular weight aromatic compound according to claim 1 , wherein said compound corresponds in structure to Formula (X) or (XI) and wherein Rand Rare independently selected from H and SOH claim 1 , Ris selected from H claim 1 , OH claim 1 , and C-Calkoxy claim 1 , or SOH claim 1 , Ris selected from H claim 1 , OH and C-Calkoxy.3. The sulfonated low molecular weight aromatic compound according to claim 1 , wherein the compound corresponds in structure to Formula (X) or (XI) and wherein:{'sup': '4', 'sub': '3', 'a) Ris SOH;'}{'sup': 4', '3, 'sub': '3', 'b) Ris SOH, Ris methoxy;'}{'sup': 4', '2', '3, 'sub': '3', 'c) Ris SOH, Rand Rare methoxy;'}{'sup': 1', '4, 'sub': '3', 'd) Rand Rare SOH;'}{'sup': 1', '4', '3, 'sub': '3', 'e) Rand Rare SOH, Ris methoxy;'}{'sup': 1', '4', '2', '3, 'sub': '3', 'f) Rand Rare SOH, Rand Rare methoxy; or'}{'sup': 2', '4', '3, 'sub': '3', 'g) Rand Rare SOH, and Ris methoxy,'}{'sup': 1', '4, 'wherein each of the other of R-Ris OH or H.'}4. The sulfonated low molecular weight aromatic compound according to claim 1 , wherein said compound corresponds in structure to Formula (XII) or (XIII) claim 1 , wherein Rand Rare independently selected from H claim 1 , OH and C-Calkoxy claim 1 , and R-Rare independently selected from H and SOH.5. The sulfonated low molecular weight aromatic compound according to claim 1 , wherein said compound corresponds in structure to Formula (XIV) or (XV) and wherein R claim 1 , Rand Rare independently selected from H claim 1 , OH and Calkoxy claim 1 , and R claim 1 , R-Rare independently selected from H and SOH.6. ...

Processes of preparing estolide compounds that include removing sulfonate residues

Provided herein are processes of preparing sulfonated estolide compounds, and the removal of sulfonate residues from those compounds to provide desulfonated estolide base oils. Exemplary sulfonated estolide compounds include those selected from the formula: wherein z is an integer selected from 0 to 15; q is an integer selected from 0 to 15; x is, independently for each occurrence, an integer selected from 0 to 20; y is, independently for each occurrence, an integer selected 0 to 20; n is equal to or greater than 0; R 6 is selected from —OH, optionally substituted alkyl, and optionally substituted aryl; and R 2 is selected from hydrogen and optionally substituted alkyl that is saturated or unsaturated, and branched or unbranched, wherein each fatty acid chain residue of said compounds is independently optionally substituted.

HPTS SERIES DERIVATIVES AND SYNTHESIS METHOD THEREFOR

Disclosed are HPTS series derivatives and a synthesis method thereof, belonging to the field of organic synthesis. The HPTS series derivatives are prepared by introducing alkylamine or alcohol into sulfonic acid groups of HPTS. The synthesis method comprises the following steps: subjecting HPTS and phosphorus oxychloride to heating and reflux reaction for 12 hours under catalysis of DMF to obtain a reaction product; introducing the reaction product into ice water, stirring, precipitating solid, and performing suction filtration to obtain HPTS-SOCl; dissolving the HPTS-SOCl in tetrahydrofuran to prepare solution A, and dissolving alkylamine or alcohol in tetrahydrofuran to prepare solution B; mixing the solution A with the solution B and then reacting for 24 hours at normal temperature, obtaining a product by rotary evaporation, and obtaining a pure compound after separation through columns. The derivatives have strong fat solubility, overcome the defect of a very strong water solubility. 1. HPTS series derivatives , wherein the HPTS series derivatives are prepared by introducing alkylamine or alcohol into sulfonic acid groups of HPTS.2. The HPTS series derivatives according to claim 1 , wherein the alkylamine is liquid alkylamine.3. The HPTS series derivatives according to claim 1 , wherein the boiling point of the alcohol is below 100° C.4. The HPTS series derivatives according to claim 3 , wherein the alkylamine is any one of diethylamine claim 3 , n-butylamine claim 3 , di-n-butylamine claim 3 , dimethylamine claim 3 , and dipropylamine.5. The HPTS series derivatives according to claim 1 , wherein the alcohol is methanol or ethanol.6. A method for synthesizing the HPTS series derivatives according to claim 1 , comprising the following steps:(1) subjecting HPTS and phosphorus oxychloride to refluxing under catalysis of DMF to obtain a reaction product;{'sub': '2', '(2) introducing the reaction product in step (1) into ice water, stirring, precipitating, and ...

PROCESS FOR PRODUCING ALKALI TAURINATE

There is disclosed a process for producing alkali taurinate by the ammonolysis of alkali ditaurinate, alkali tritaurinate, or a solution of alkali ditaurinate and alkali tritaurinate in the presence of one or more catalysts. The ammonolysis reaction is catalyzed by alkali salts of hydroxide, sulfate, sulfite, phosphate, or carbonate. 1. A process for producing alkali taurinate , comprising:(a) adding an excess of ammonia and one or more catalysts to a solution of alkali ditaurinate, alkali tritaurinate, or a mixture of alkali ditaurinate and alkali tritaurinate;(b) subjecting the solution of step (a) to an ammonolysis reaction; and(c) removing excess ammonia to yield a mixture of alkali taurinate, alkali ditaurinate, and alkali tritaurinate.2. The process according to claim 1 , wherein alkali ditaurinate or alkali tritaurinate is produced from diethanolamine or triethanolamine claim 1 , respectively.3. The process according to claim 1 , wherein the mixture of alkali ditaurinate and alkali tritaurinate are produced by a process which comprises an ammonolysis reaction of alkali isethionate to alkali taurinate claim 1 , alkali ditaurinate claim 1 , and alkali tritaurinate.4. The process according to claim 1 , wherein the mixture of alkali ditaurinate and alkali tritaurinate is the mother liquor of taurine crystallization.5. The process according to claim 1 , one or a combination of two or more catalysts for the ammonolysis reaction is selected from the group of alkali salts of hydroxide claim 1 , carbonate claim 1 , sulfate claim 1 , sulfite claim 1 , phosphate claim 1 , nitrate claim 1 , and carboxylate.6. The process according to claim 1 , wherein the catalyst for the ammonolysis reaction is selected from alkali salts of hydroxide.7. The process according to claim 1 , wherein the catalyst for the ammonolysis reaction is sodium hydroxide.8. The process according to claim 1 , wherein the alkali metals are lithium claim 1 , sodium claim 1 , or potassium. This ...

Conjugates and associated methods of producing them for the prevention or treatment of nicotine addiction

The present invention relates in part to chemical compounds, and methods for producing these compounds. The compounds may also be incorporated into compositions to enhance quit rates or reduce relapse in smoking cessation and further in treating nicotine-related dependence.

Processes of preparing estolide compounds that include removing sulfonate residues

Provided herein are processes of preparing sulfonated estolide compounds, and the removal of sulfonate residues from those compounds to provide desulfonated estolide base oils. Exemplary sulfonated estolide compounds include those selected from the formula: wherein z is an integer selected from 0 to 15; q is an integer selected from 0 to 15; x is, independently for each occurrence, an integer selected from 0 to 20; y is, independently for each occurrence, an integer selected 0 to 20; n is equal to or greater than 0; R 6 is selected from —OH, optionally substituted alkyl, and optionally substituted aryl; and R 2 is selected from hydrogen and optionally substituted alkyl that is saturated or unsaturated, and branched or unbranched, wherein each fatty acid chain residue of said compounds is independently optionally substituted.

PROCESS FOR PRODUCING TAURINE

There is disclosed a process for producing taurine by the ammonolysis of alkali isethionate in the presence of alkali ditaurinate or alkali tritaurinate, or their mixture, to inhibit the formation of byproducts and to continuously convert the byproducts of the ammonolysis reaction to alkali taurinate. The production yield is increased to from 90% to nearly quantitative. The ammonolysis reaction is catalyzed by alkali salts of hydroxide, sulfate, sulfite, phosphate, or carbonate. 1. A process for producing taurine from alkali isethionate , comprising:(a) mixing alkali isethionate with a solution of alkali ditaurinate, alkali tritaurinate, or their mixture in the presence of one or more catalysts;(b) adding an excess of ammonia to the (a) and subjecting the solution to ammonolysis reaction to yield a mixture of alkali taurinate, alkali ditaurinate, and alkali tritaurinate;(c) removing excess ammonia and neutralizing with an acid to obtain a crystalline suspension of taurine; and(d) separating taurine by means of solid-liquid separation.2. The process according to claim 1 , wherein alkali taurinate and alkali tritaurinate are produced from diethanolamine and triethanolamine claim 1 , respectively.3. The process according to claim 1 , wherein a mixture of alkali ditaurinate and alkali tritaurinate is the byproduct of the ammonolysis reaction of alkali isethionate.4. The process according to claim 1 , wherein an acid is selected from hydrochloric acid claim 1 , hydrobromic acid claim 1 , sulfuric acid claim 1 , nitric acid claim 1 , and organic carboxylic acids.5. The process according to claim 1 , wherein the mother liquor after separating taurine and alkali salt is continuously recycled and mixed with a new batch of alkali isethionate for the ammonolysis reaction.6. The process according to claim 1 , one or a combination of two or more catalysts for the ammonolysis reaction is selected from alkali salts of hydroxide claim 1 , carbonate claim 1 , sulfate claim 1 , ...

CYCLIC PROCESS FOR PRODUCTION OF TAURINE FROM ALKALI VINYL SULFONATE

A cyclic process is disclosed for the production of taurine from alkali vinyl sulfonate in a high overall yield by continuously converting the byproducts of the ammonolysis reaction, sodium ditaurinate and sodium tritaurinate, to sodium taurinate. Sodium sulfate and residual taurine in the crystallization mother liquor are efficiently separated by converting taurine into a highly soluble form of sodium taurinate or ammonium taurinate while selectively crystallizing sodium sulfate. 1. A cyclic process for the production of taurine from alkali vinyl sulfonate comprising:(a) adding an excess of ammonia to a solution of alkali vinyl sulfonate and subjecting the solution to ammonolysis reaction in the presence of one or more catalysts to yield a mixture of alkali taurinate, alkali ditaurinate, and alkali tritaurinate;(b) recovering the excess ammonia from (a) and neutralizing the solution with sulfuric acid to obtain a crystalline suspension of taurine in a solution of alkali sulfate, alkali ditaurinate, and alkali tritaurinate;(c) separating taurine from (b) to provide a mother liquor;(d) adjusting the pH of the mother liquor to basic to convert taurine present in the mother liquor to alkali taurinate and prevent the crystallization of taurine and removing alkali sulfate from the mother liquor by performing evaporative crystallization and cooling crystallization through solid-liquid separation; and(e) returning the mother liquor of (d) to (a) for further ammonolysis of alkali ditaurinate and alkali tritaurinate.2. The process according to claim 1 , wherein the mother liquor containing alkali ditaurinate and alkali tritaurinate is mixed with a new batch of alkali vinyl sulfonate to inhibit the formation of alkali ditaurinate and alkali tritaurinate claim 1 , and to convert alkali ditaurinate and alkali tritaurinate to alkali taurinate during the ammonolysis.3. The process according to claim 2 , wherein alkali ditaurinate and alkali tritaurinate in the returning mother ...

Method for preparing methanedisulfonic acid

Disclosed is a method for preparing methanedisulfonic acid, comprising an acidification, wherein the acidification comprises that methanedisulfonate reacts with an acidifier to form a mixture containing methanedisulfonic acid. The disclosure has high yield, low cost, and the process are environmental friendly. 1. A method for preparing methanedisulfonic acid , comprising an acidification ,wherein the acidification comprises subjecting a methanedisulfonate to reacting with an acidifier to obtain a mixture containing methanedisulfonic acid.2. The method for preparing methanedisulfonic acid according to claim 1 , further comprising a sulphination before the acidification claim 1 ,wherein the sulphination comprises subjecting a sulphinating reagent to reacting with a dihalomethane to obtain a mixture containing methanedisulfonate; andoptionally, the method further comprising apurification after the acidification.3. The method for preparing methanedisulfonic acid according to claim 1 , further comprising apurification after the acidification.4. The method for preparing methanedisulfonic acid according to claim 3 , wherein the purification comprises filtering the mixture containing methanedisulfonic acid obtained after the acidification claim 3 , concentrating the filtrate obtained after the filtration claim 3 , decolorizing the obtained concentrated filtrate with activated carbon claim 3 , subjecting the concentrated filtrate to freezing crystallization after removing the activated carbon by filtration claim 3 , and removing the crystallized substances by filtration claim 3 , thus obtaining an aqueous solution of methanedisulfonic acid.5. The method for preparing methanedisulfonic acid according to claim 1 , wherein the methanedisulfonate is one or a mixture of two or more selected from a group consisting of calcium methanedisulfonate claim 1 , barium methanedisulfonate claim 1 , ferrous methanedisulfonate claim 1 , ferric methanedisulfonate claim 1 , silver ...

CYCLIC PROCESS FOR PRODUCING TAURINE

There is disclosed a process for producing taurine by the ammonolysis of alkali isethionate in the presence of alkali ditaurinate or alkali tritaurinate, or their mixture, to inhibit the formation of byproducts and to continuously convert the byproducts of the ammonolysis reaction to alkali taurinate. Alkali taurinate is neutralized with isethionic acid to obtain taurine and to regenerate alkali isethionate. The production yield is increased to from 90% to nearly quantitative. The ammonolysis reaction is catalyzed by alkali salts of hydroxide, sulfate, sulfite, phosphate, or carbonate. 1. A cyclic process for producing taurine from alkali isethionate , comprising:(a) adding one or a combination of two or more catalysts to an ammonia solution of a mixture of alkali isethionate, alkali ditaurinate, and alkali tritaurinate, and subjecting the solution of to ammonolysis reaction to yield a mixture of alkali taurinate, alkali ditaurinate, and alkali tritaurinate;(b) removing excess ammonia and neutralizing with isethionic acid to obtain a crystalline suspension of taurine in a solution of alkali isethionate, alkali ditaurinate, and alkali tritaurinate.(c) separating taurine by means of solid-liquid separation; and(d) returning the mother liquor of (c) to step (a) for further ammonolysis.2. The process according to claim 1 , wherein one or a combination of two or more catalysts for the ammonolysis reaction is selected from alkali salts of hydroxide claim 1 , carbonate claim 1 , sulfate claim 1 , sulfite claim 1 , phosphate claim 1 , nitrate claim 1 , or carboxylate.3. The process according to claim 1 , wherein the production yield of taurine is greater than 85%.4. The process according to claim 1 , wherein the production yield of taurine is greater than 90%.5. The process according to claim 1 , wherein the production yield of taurine is greater than 95% claim 1 , to nearly quantitative.6. The process according to claim 1 , wherein the alkali metals are lithium claim 1 , ...

Sulfonated iminodialkanoic acids formed from an iminodialkylnitrile and a sultone and methods for use thereof

Complexation of metal ions using chelating agents within a subterranean formation can often be desirable, such as to temper the formation of metal-containing precipitates. However, many chelating agents are produced commercially in an alkali metal salt form that may not be entirely suitable for use downhole, particularly in subterranean formations containing a siliceous material. The working pH range of some types of chelating agents may also be limiting. Treatment fluids comprising an aqueous carrier fluid having an acidic pH, a sulfonated iminodialkanoic acid, and ammonium ions may at least partially address downhole precipitation issues, while providing further advantages as well. Methods for forming sulfonated iminodialkanoic acids can comprise reacting an iminodialkylnitrile with a sultone under acidic conditions to form a fluid comprising a sulfonated iminodialkanoic acid and ammonium ions.

PROCESS FOR FLUORINATION OF SULPHONYL HALIDE COMPOUNDS

The preparation is described of a compound of formula (I) comprising an —SOF function by reacting a compound of formula (II) with a fluorinating agent selected from hydrofluoric acid and an ionic fluoride of a monovalent or divalent cation: 2. The preparation process as claimed in claim 1 , wherein the radicals R1 and R′1 are perhalogenated so that b=3 and a=0.3. The preparation process as claimed in claim 1 , wherein the radical R of the compound (I) is the radical R1 wherein n=1 claim 1 , a=0 and b=3 claim 1 , or n=1 claim 1 , a=1 claim 1 , b=2 or else n=1 claim 1 , a=2 and b=1.4. The preparation process as claimed in claim 1 , wherein the process is carried out in the gas phase and wherein the fluorinating agent is hydrofluoric acid.5. The preparation process as claimed in claim 4 , wherein the process uses at least one fluorination catalyst comprising chromium claim 4 , zinc claim 4 , nickel claim 4 , a mixture of chromium and zinc claim 4 ,. or a mixture of chromium and nickel.6. The preparation process as claimed in claim 4 , wherein the ratio of the number of moles of hydrofluoric acid to the number of moles of halogenated compound of formula (II) varies between 1 and 30.7. The preparation process as claimed in claim 1 , wherein the process is carried out in the liquid phase in the presence of hydrofluoric acid using an antimony-based fluorination catalyst.8. The preparation process as claimed in claim 1 , wherein the process is carried out in the liquid phase in the presence of an ionic fluoride of a monovalent cation selected from the group consisting of a fluoride of an alkali metal cation and a fluoride of an onium cation.9. The preparation process as claimed in claim 8 , wherein said alkali metal cation is potassium.10. The preparation process as claimed in claim 8 , wherein said fluoride of an onium cation is selected from the group consisting of an ammonium fluoride wherein the cation corresponds to the formula N(RRRR) and a phosphonium fluoride ...

PROCESS FOR PREPARATION OF ISOSULFAN BLUE

Isosulfan blue and processes for the preparation thereof are provided. A process is also provided for preparation of the intermediate, 2-chlorobenzaldehyde-5-sulfonic acid, sodium salt of formula (2), used in the preparation thereof and a procedure for the isolation of benzaldehyde-2,5-disulfonic acid, di-sodium salt of the formula (3). Also provided is a process for the preparation of an isoleuco acid of formula (4), which upon oxidation gives rise to isosulfan blue of pharmaceutical grade which can be used for preparation of pharmaceutical formulations. The isolation and purification procedures provided in the process provide substantially pure isosulfan blue with HPLC purity 99.5% or greater. 1. A compound N-[4-[[4-(diethyl amino) phenyl] (2 ,5-disulfophenyl) methylene]-2 ,5-cyclohexadien-1-ylidene]-N-ethylethanaminium , sodium salt having a purity of at least 99.0% by HPLC.2. The compound according to having a purity between 99.0% and 99.5% by HPLC.3. The compound according to having less than 20 ppm silver.4. The compound according to having a purity greater than 99.5% by HPLC.7. The compound according to wherein the process of preparing 2-chlorobenzaldehyde-5-sulfonic acid claim 6 , sodium salt of formula (2) comprises reacting 2-chlorobenzaldehyde with sulfuric acid.8. The compound according to wherein the polar solvent is methanol.10. The compound according to wherein the process comprises recrystallization of N-[4-[[4-(diethylamino) phenyl] (2 claim 5 ,5-disulfophenyl) methylene]-2 claim 5 ,5-cyclohexadien-1-ylidene]-N-ethylethanaminium using a solvent selected from the group consisting of a polar solvent claim 5 , a non-polar solvent and a combination thereof to afford HPLC purity greater than 99.5%.11. A solution containing N-[4-[[4-(diethyl amino) phenyl] (2 claim 5 ,5-disulfophenyl) methylene]-2 claim 5 ,5-cyclohexadien-1-ylidene]-N-ethylethanaminium claim 5 , sodium salt claim 5 , the N-[4-[[4-(diethyl amino) phenyl] (2 claim 5 ,5-disulfophenyl) ...

Phosphono-phosphate and anionic group containing polymers

Disclosed are novel phosphono-phosphate and anionic group containing polymer compositions that have targeted uses with divalent cations and surfaces having divalent cations. These compounds can be used to deliver anionic character to surfaces such as calcium hydroxyapatite.

一种对氨基苯磺酸的制备方法

本发明公开了一种对氨基苯磺酸的制备方法，所述制备方法包括以下步骤：(1)还原磺化：在反应器中依次加入水、非质子极性有机溶剂、硝基苯、还原磺化剂，升温至95～130℃回流反应；(2)除盐：将步骤(1)得到的物料降温至0～20℃，析出无机盐，然后抽滤或压滤，收集滤液1；(3)酸化：将步骤(2)得到的滤液1升温至30～70℃，加入硫酸调节pH至1～3，然后抽滤或压滤，收集滤液2和滤饼，滤饼烘干即得到对氨基苯磺酸产品。本发明实现硝基苯还原磺化一步反应，得到的对氨基苯磺酸产品纯度高，并且无三废问题，真正做到清洁生产。

一种农药制剂润湿剂及其制备方法和在农药制剂中的应用

本发明涉及一种农药助剂，具体涉及一种农药制剂润湿剂及其制备方法和其在农药制剂中的应用。所述农药制剂润湿剂的制备方法，包括以下步骤：在反应器中加入水杨酸和氢氧化钾，之后滴加三乙烯四胺，得到中间体单酰胺，在反应器中再加入去氢松香酸经过一系列反应得到中间体不对称双酰胺；将中间体不对称双酰胺和丁酮加入反应器中，滴加丙烷磺内酯，抽滤并用丁酮多次洗涤，并重结晶，用碱的乙醇溶液中和析出白色固体，抽滤后，真空干燥得农药制剂润湿剂。本发明的有益效果在于：本发明提供的农药制剂润湿剂为不对称、双酰胺、双磺酸盐结构，具有较好的表面活性、复配性能和润湿性能，提高农药的吸收率。

制备邻－(烷氧羰基)苯甲磺酰氯衍生物的方法

本发明涉及制备邻-(烷氧羰基)苯甲磺酰氯衍生物的方法，更具体地说，本发明涉及制备式1所示的邻-(烷氧羰基)苯甲磺酰氯的新方法，其中用是环状的酯化合物的内酯化合物作为原料，以邻-(氯甲基)苯甲酰氯、邻-(氯甲基)苯甲酸酯衍生物和邻-(烷氧羰基)苯甲基硫代硫酸盐作为中间体，式1化合物是合成磺酰脲类除草剂的重要化合物。在所述通式中，X代表氢、卤素、C 1 -C 6 烷基、C 1 -C 6 卤代烷基、C 1 -C 6 烷氧基、C 1 -C 6 烷氧羰基、硝基或苯基；R代表C 1 -C 6 烷基、C 1 -C 6 卤代烷基或C 3 -C 6 环烷基；n代表1-4的整数，其表示取代基的数目。

一种4-氰基-3-(三氟甲基)苯-1-磺酰氯的合成方法

本发明涉及有机合成领域，公开了一种4‑氰基‑3‑(三氟甲基)苯‑1‑磺酰氯的合成方法，包括：将氯化亚铜加入水内，冰水浴下滴加二氯亚砜，室温放置8～12h，得溶液a；将4‑氨基‑2‑(三氟甲基)苯甲腈冰水浴下加入酸中，0～5℃滴加亚硝酸钠水溶液并搅拌30～60min，经有机溶剂a助溶，并于0～5℃搅拌20～40min，得反应液a；将反应液a滴加入溶液a，并加入有机溶剂a助溶，0～35℃反应0.5～2h，冲水，经有机溶剂b萃取，纯化，即得。本发明的合成方法原料易得、反应条件温和，选择性高，收率约为85％，工艺简单，成本低，可大规模生产。

PROCESS FOR THE PREPARATION OF ETHANE SULPHONATE BASE TENSID MIXTURES AND THEIR USE

In a process for preparing tenside mixtures based on alkyl ether sulphonates or their salts (ether sulphonates) as the main component and which are particularly suitable for use in tertiary crude oil extraction, alkyl ether sulphates are reacted with an aqueous solution of an alkali sulphate at temperatures of 160 to 220 DEG C. To prepare admixtures of the ether sulphonates based on alkoxylated alcohols of natural and/or synthetic origin and which are essentially free from sulphate salts, not more than approximately equal quantities of the alkoxylated alcohols are reacted in aqueous medium of weakly alkaline pH with a stoichiometric excess of alkali sulphate and, if necessary, allowed to further react, preferably under the specified reaction conditions. The resultant tenside mixture is then extracted with at least essentially water-insoluble alcohols at lower, but still high, temperatures. The tenside mixtures obtained can be used, in particular admixed with residual alcohol from the extraction stage, for tertiary crude oil extraction.

Polymers containing phosphono-phosphate groups and anionic groups

本发明公开了含有膦酰基‑磷酸根基团和阴离子基团的新型聚合物组合物，所述聚合物组合物具有对于二价阳离子和具有二价阳离子的表面的靶向用途。这些化合物可用于向表面诸如钙羟基磷灰石递送阴离子特征。

Copolymerizable ethylenically unsaturated surfactants and their use in polymerization processes

Separation and purification equipment of taurine

本发明涉及一种牛磺酸的分离纯化设备，适用于以环氧乙烷为原料合成牛磺酸的方法。具体包括利用离子化多通道喷嘴装置将环氧乙烷与亚硫酸氢钠及其它气、液、固相催化剂以纳米级微粒混合制备2‑羟基乙磺酸钠，再经高温高压和浓缩制备牛磺酸钠，采用亚硫酸氢钠中和牛磺酸钠料液；在陶瓷纳米金属分子笼组件，一种含有机硫和氮的三齿桥联配体，通过该配体与两价的镍、鈀或铂离子自组装反应，构筑了具有O h 对称的立方体金属‑有机笼子，同时容纳氢离子和钠离子的交换和溶剂分子催化，得到牛磺酸。母液经浓缩分离得到亚硫酸钠作为环氧乙烷反应的原料及二氧化硫的吸收和转运载体、中和牛磺酸钠料液的原料。实现牛磺酸无废液循环生产。

Fullerene derivative production method, fullerene derivative, proton conductor, and electrochemical device

Preparation method of taurine

本发明涉及一种牛磺酸的制备方法。该方法包括以下步骤：(1)乙烯与SO 2 加成反应，得到1,1‑二氧化环硫乙烷；(2)1,1‑二氧化环硫乙烷、氨和水进行氨解反应，得到牛磺酸。所用原料乙烯、SO 2 、氨均为较为廉价易得原料，所用乙烯也并无环氧乙烷的安全隐患。此外，本发明提供的牛磺酸合成方法还具有工艺绿色环保、操作方便、成本低廉、收率较高、易工业化生产等优点。

Method for producing perfluorosulfonic acid having ether structure and derivative thereof, and surfactant containing fluorine-containing ether sulfonic acid compound and derivative thereof

이 방법에서는, 불화수소산에 R H 2 OR H 1 SO 2 F 를 첨가하여 농후 용액 (수소 결합 착물) 으로 하고, 그 상태에서, F 2 가스를 사용하는 액상 반응계에 공급하거나, R H 2 OR H 1 SO 2 Cl 을 불화수소산에 첨가하여, HCl 을 방출시킴으로써 R H 1 OR H 2 SO 2 F 로 변환하고, 이것을 그 상태에서, F 2 가스를 사용하는 액상 반응계에 공급한다. 이로써, 안전하게 불소화를 실시할 수 있고, 이성화 등이 일어나지 않고, 목적하는 구조의 화합물을 저비용으로 제조할 수 있다. In this method, R H 2 OR H 1 SO 2 F is added to hydrofluoric acid to form a rich solution (hydrogen bonding complex), and in this state, it is fed to a liquid phase reaction system using F 2 gas, or R H 2 OR H 1 SO 2 Cl is added to hydrofluoric acid to convert it into R H 1 OR H 2 SO 2 F by releasing HCl, and this is supplied to the liquid phase reaction system using F 2 gas in this state. Thereby, fluorination can be safely carried out, isomerization does not occur, and a desired structure compound can be produced at a low cost.

Preparation method of ammonium hydroxyalkyl / alkanoylalkyl sulfonate (PREPARATION OF AMMONIUM HYDROXYALKYL / ALKANOYLALKYL SULFONATES)

본 발명은 중아황산암모늄 밍 알킬렌 옥사이드를 반응시켜 암모늄 하이드록시알킬 설포네이트를 제조하는 방법을 개시한다. 본 발명의 방법에서는, 암모늄 하이드록시알킬 설포네이트내의 불순물, 예를 들면 알킬렌 글리콜 및 알칸올아민의 양을 최소화시키기 위하여 중아황산암모늄 및 알킬렌 옥사이드의 거의 전 방응기간을 통하여 pH를 비교적 낮은 값으로 유지시킨다. 이러한 암모늄 하이드록시알킬 설포네이트를 지방산과 반응시켜 제조한 암모늄 알카노일 알킬 설포네이트는 주변온도에서 등명하여 등명한 액체 생성물내의 계면활성제로서 유용한 수용액을 형성한다. 또한, 본 발명은 차아인산 또는 이의 수용성 염의 존재하에 반응을 수행함으로써 지방산-암모늄 하이드록시알킬 설포네이트를 반응시키는데 사용되는 금속 반응기내의 부식을 억제하는 방법도 개시한다.

The product and preparation method of micro Nano material, its surface hydrophilic substance covalent modification

本发明公开了一种微纳米材料、其表面用亲水物质共价修饰的产物及制备方法；微纳米材料表面含羧基或潜在羧基并转变成活泼酯；表面用亲水物质共价修饰的产物，由表面活泼酯与含脂肪族伯胺或/和脂肪族仲胺的亲水化合物或/和亲水聚合物为修试剂成酰胺键共价修饰而得；制备时，用含羧基或/和潜在羧基单体在聚合材料表面生成足够多羧基或/和潜在羧基并转变成活泼酯，再与带脂肪族伯胺和/或仲胺、潜在兼性离子基团、亲水连接臂且体积适中的修饰剂成酰胺键获得共价修饰层；在共价修饰产物表面重复生成活泼酯后与亲水修饰剂成酰胺键的过程实现多层共价修饰，用中等体积亲水修饰剂高效覆盖微纳米材料表面而显著降低修饰产物对生物分子非特异吸附。

Multi-grafting-site nano carbon material and active nano carbon material, preparation methods thereof and oil displacement system for ultra-low permeability reservoir

本发明属于油田化学领域，公开了一种多接枝位点纳米碳材料和活性纳米碳材料及其制备方法和超低渗油藏用驱油体系。所述多接枝位点纳米碳材料包括式(1)所示的结构单元、羟基和式(2)所示的结构单元；其中，R选自甲苯基、二苯基甲烷基、异佛尔酮基和二环己基甲烷基中的一种或多种；该超低渗油藏用驱油体系具有较高界面活性，油水界面张力降低达10 ‑2 mN/m数量级，能够显著提高洗油效率；

A kind of preparation method of methylene-disulfonic acid

本发明公开了一种亚甲基二磺酸的制备方法，包括酸化反应；其中，所述酸化反应包括：将亚甲基二磺酸盐与酸化试剂反应，得到含有亚甲基二磺酸的混合物。采用本发明收率高、成本低，且工艺环保。

Process for prepn. of beta-substituted sulphonic acids and/or sulphonates

本发明是关于制备β-取代的磺酸和/或磺酸盐的方法，该方法包括使内烯烃的β-磺内酯(下式)与亲核试剂反应，条件是该亲核试剂不是氢或氢氧离子， 其中基团R 1 、R 2 、R 3 和R 4 各自独立地为直链或支链的烷基或氢，R 1 、R 2 、R 3 和R 4 的碳原子总数为6～24，并且R 1 和R 2 中至少一个以及R 3 和R 4 中至少一个为烷基。

Filter medium, filter medium manufacturing method, water treatment module and water treatment apparatus

この濾材は、水と油とを含む液体を分離対象とし、前記液体の流路を有する濾材であって、前記流路を構成する基材と、当該流路の少なくとも一部の表面に存在している、一種又は二種以上の含窒素フッ素系化合物とを有する。前記含窒素フッ素系化合物は、分子中に撥油性賦与基と、アニオン型、カチオン型及び両性型からなる群から選択されるいずれか１の親水性賦与基とを含む。 This filter medium is a filter medium that has a liquid flow path as a separation target and contains a liquid containing water and oil, and is present on at least a part of the surface of the base material constituting the flow path. And one or more nitrogen-containing fluorine-based compounds. The nitrogen-containing fluorine-based compound includes an oil repellency-imparting group and any one hydrophilic imparting group selected from the group consisting of an anionic type, a cationic type, and an amphoteric type in the molecule.

Method for grafting substituted difluoromethyle group

本发明涉及将取代二氟甲基接枝到含有至少一个亲电子官能团的化合物上的方法,包括以下步骤:i)让含有至少一个亲电子官能团的化合物与亲核试剂接触,所述亲核试剂包括:a)通式Ea－CF 2 －COOH的氟代羧酸,其中Ea表示吸电子原子或基团,它至少部分地用有机或无机阳离子成盐,和b)极性非质子传递溶剂,和ii)让反应介质暴露于微波的作用之下。所述方法尤其可用于制备亚磺酸或含氟亚磺酸。

Process for the preparation of ª ‡ -chlorinated sulfochlorides on an aliphatically bonded carbon atom

Process for sulfonating mixture of long-chain olefin and alkane by using sulfur trioxide gas

一种用三氧化硫气体磺化长链烯烃与烷烃混合物的工艺是长链烯烃与烷烃的混合物与三氧化硫与空气的混合气体进行磺化，先采用超重力反应器进行分离，得到烯基磺酸、磺内酯与烷烃混合物，再采用分子蒸馏的方法对磺内酯与烷烃混合物进行分离，得到烷烃和磺内酯，之后进行中和与水解，得到烯基磺酸盐和羟基烷基磺酸盐。本发明具有能耗低，安全环保，产品质量高的优点。

Preparation of internal olefin sulfonate

Water-soluble functionalized fullerenes

Provided herein are water-soluble, functionalized fullerenes, and processes for producing water-soluble, functionalized fullerenes. The process includes sulfonating a fullerene in an acidic solution comprising sulfuric acid to produce a sulfonated fullerene, isolating the sulfonated fullerene from the acidic solution without neutralizing the acidic solution, reacting the sulfonated fullerene with hydrogen peroxide to form a reaction product, and isolating a polyhydroxylated fullerene from the reaction product produced from reacting the sulfonated fullerene with the hydrogen peroxide. The process of producing water-soluble fullerenes further includes functionalizing a polyhydroxylated fullerene with one or more pendant functional groups by reacting the polyhydroxylated fullerene with one or more functional group precursors.

Water-soluble functionalized fullerenes

Provided herein are water-soluble, functionalized fullerenes, and processes for producing water-soluble, functionalized fullerenes. The process includes sulfonating a fullerene in an acidic solution comprising sulfuric acid to produce a sulfonated fuUerene, isolating the sulfonated fullerene from the acidic solution without neutralizing the acidic solution, reacting the sulfonated fullerene with hydrogen peroxide to form a reaction product, and isolating a polyhydroxylated fullerene from the reaction product produced from reacting the sulfonated fullerene with the hydrogen peroxide. The process of producing water-soluble fullerenes further includes functionalizing a polyhydroxylated fullerene with one or more pendant functional groups by reacting the polyhydroxylated fullerene with one or more functional group precursors.

Water-soluble functionalized fullerenes

Provided herein are water-soluble, functionalized fullerenes, and processes for producing water-soluble, functionalized fullerenes. The process includes sulfonating a fullerene in an acidic solution comprising sulfuric acid to produce a sulfonated fullerene, isolating the sulfonated fullerene from the acidic solution without neutralizing the acidic solution, reacting the sulfonated fullerene with hydrogen peroxide to form a reaction product, and isolating a polyhydroxylated fullerene from the reaction product produced from reacting the sulfonated fullerene with the hydrogen peroxide. The process of producing water-soluble fullerenes further includes functionalizing a polyhydroxylated fullerene with one or more pendant functional groups by reacting the polyhydroxylated fullerene with one or more functional group precursors.

Preparation of ammonium hydroxyalkyl/alkanoylalkyl sulfonates

一种通过使亚硫酸氢铵与烯化氧反应制备羟烷基磺酸铵的方法，其中在上述反应的大部分时间内pH值均被保持在较低数值，以便最大限度地减少羟烷基磺酸铵中杂质如二醇与链烷醇胺的数量。通过使羟烷基磺酸铵与脂肪酸反应制备的链烷酰基烷基磺酸铵可形成于环境温度下透明的水溶液，因而适用作透明液体产物的表面活性剂。通过在次磷酸及其水溶性盐存在下使羟烷基磺酸铵与脂肪酸反应防止金属反应器被腐蚀。

Preparation method of p-acetamidobenzenesulfonyl chloride

本发明提供了一种对乙酰氨基苯磺酰氯的制备方法。该方法以乙酰苯胺和氯磺酸为原料在催化剂存在下经磺化反应制得对乙酰氨基苯磺酸，再与氯代试剂进行氯化反应得到对乙酰氨基苯磺酰氯产品。本发明工艺简单，对设备无特殊要求，操作简便，三废较少，产品质量好，适于工业化生产。

Filter material, the manufacturing method of filter material, water process module and water treatment facilities

本发明的滤材将包含水和油的液体作为分离对象，并具有所述液体的流路，所述滤材具有构成所述流路的基材和存在于该流路的至少一部分表面的一种或两种以上的含氮氟系化合物。所述含氮氟系化合物在分子中包含拒油性赋予基和选自阴离子型、阳离子型及两性型中的任一个亲水性赋予基。

Method of introduction of substituted difluoromethyl group

FIELD: chemical technology. SUBSTANCE: invention relates to method of introduction of substituted difluoromethyl group and compound comprising at least one electophilic group. Method involves the following stages: I) contact of the above- mentioned compound comprising at least one electophilic group with nucleophilic agent containing: a) fluorocarboxylic acid of the formula Ea-CF 2 -COOH where Ea means atom or group showing electron-accepting properties and converted at least partially to salt form with organic or inorganic cation, and b) polar aprotonic solvent; and II) irradiation of reaction medium by microwave radiation. This ensures to obtain fluoro-containing sulfinic or sulfonic acids. EFFECT: improved method of introduction. 27 cl, 1 tbl, 8 ex (19) 13) ВИ” 2192 414 ' (51) МПК? С2 С 07 С 313/02, 319/44, 321/28 РОССИЙСКОЕ АГЕНТСТВО ПО ПАТЕНТАМ И ТОВАРНЫМ ЗНАКАМ 12) ОПИСАНИЕ ИЗОБРЕТЕНИЯ К ПАТЕНТУ РОССИЙСКОЙ ФЕДЕРАЦИИ (21), (22) Заявка: 99104288/04, 30.07.1997 (71) Заявитель: РОДИА ШИМИ (ЕК) (24) Дата начала действия патента: 30.07.1997 (72) Изобретатель: ФОРА Жерар (ЕК), (30) Приоритет: 01.08.1996 ЕВ 9609753 МАС Жан-Мануэль (ЕВ), СЭН-ЖАЛЬМЕ Лоран 01.08.1996 ЕВ 9609754 (ЕВ) (43) Дата публикации заявки: 20.02.2001 (73) Патентообладатель: сч РОДИА ШИМИ (ЕК) о (46) Дата публикации: 10.11.2002 (74) Патентный поверенный: (56) Ссылки: ЕР 165135 АД, 18.12.1985. ЕВ Лебедева Наталья Георгиевна 2593808, А2, 07.08.1987. КЦ 503858, АЛ, о 16.03.1976. = (85) Дата перевода заявки РСТ на национальную фазу: 01.03.1999 Подробнее

Process for preparing perfluoroalkanesulfonyl fluorides

A process for preparing perfluoroalkanesulfonyl fluorides, e.g., perfluoromethanesulfonyl fluoride, comprises electrochemically fluorinating in the presence of anhydrous hydrogen fluoride at least one precursor compound selected from the group consisting of α,β-difluoroalkane-β-sultones, e.g., 1,1,2,2-tetrafluoroethane sultone, and the corresponding α-halocarbonylfluoroalkanesulfonyl halides, e.g., fluorocarbonyldifluoromethanesulfonyl fluoride. The process can be used to prepare perfluoroalkanesulfonyl fluorides in good yield and can be, for example, both more electrically-efficient and more fluorine-efficient than the conventional preparative method involving the electrochemical fluorination of hydrocarbon alkanesulfonyl halides.

Agomelatine acid radical composite, and preparation method and application thereof

The present invention relates to an Agomelatine acid radical complex in formula (I) and the preparation method thereof (HX = H 2 SO 4 , RSO 3 H (R = CH 3 , Ph, 4-CH 3 Ph)). The solubility of the Agomelatine acid radical complex obtained by the method of the present invention is significantly improved compared with Agomelatine, has good stability and higher purity, and is suitable for application in finished-product medicinal preparations. The preparation process is quite simple, and a product with high purity can be obtained without special operations. (HX = H 2 SO 4 , RSO 3 H(R= CH 3 , Ph or 4-CH 3 Ph)).

HPTS series derivates and synthetic method

本发明公开了HPTS系列衍生物及合成方法，属于有机合成技术领域。所述HPTS系列衍生物是在HPTS的磺酸基团引入烷基胺或醇制备而成，合成方法包括以下步骤：1)将HPTS与三氯氧磷投入反应，在DMF催化作用下加热回流反应12h，得到反应产物；2)反应产物导入冰水中并搅拌，析出固体、抽滤，得到HPTS‑SO 2 Cl；3)将HPTS‑SO 2 Cl溶解于四氢呋喃中制备成溶液A，将烷基胺或醇溶解于四氢呋喃中制备成溶液B；将溶液A和溶液B混合后常温下反应24h，旋蒸得产品，经过柱分离后可获得纯化合物。该衍生物具有较强的脂溶性，克服了HPTS水溶性极强，应用范围受限的缺陷，拓宽了HPTS的应用范围。

α-HALOENAMINE REAGENTS

본 발명은 고정화된 할로엔아민 시약, 고정화된 3차 아미드, 제조 방법, 사용방법을 기술한다.

Process for production of fluorinated sulfonyl fluorides

本发明提供了作为离子交换树脂原料等有用的含氟磺酰氟的制造方法，以及在该制造方法中作为中间体的有用的新型化学物质。即提供了使用以卤素为必要成分的氧化剂氧化Y－S－R A －E－R B 生成XSO 2 －R A －E－R B ，当X是氟原子时，将该化合物直接在液相中与氟反应，当X为氟以外的卤素原子时，将X转换成氟原子后在液相中与氟反应生成FSO 2 －R AF －E F －R BF ，再分解得到FSO 2 －R AF －COF的方法(式中，R A 表示亚烷基等2价的有机基团；R B 表示全氟烷基等1价的有机基团；E表示－CH 2 OCO－；Y表示氰基等1价的有机基团；X表示卤素原子；R AF 表示R A 被氟化所得的2价有机基团；R BF 表示与R B 相同的基团等；E F 表示－CF 2 OCO－)。

Preparation method of 2- [ [ tri (hydroxymethyl) methyl ] amino ] ethanesulfonic acid

本发明公开了一种2‑[[三(羟甲基)甲基]氨基]乙磺酸的制备方法，包括如下步骤：将三羟基甲基氨基甲烷与1,2‑二卤代乙烷溶于溶剂中，在搅拌下，加热升温至回流反应，控制溶液的pH值≥7.0，得到第一中间反应液；将亚硫酸钠加入第一中间反应液中，在催化剂的作用下，加热升温至回流反应，得到第二中间反应液；将第二中间反应液经过降温、过滤后，然后加入阳离子交换树脂，进行吸附，再经过脱溶剂、结晶处理后，得到2‑[[三(羟甲基)甲基]氨基]乙磺酸。本发明采用两步一锅法合成，其反应的收率高，后处理工艺简便，产品纯度好，同时克服了使用2‑卤代乙磺酸所带来的低收率或者三废的问题。

Method for synthesizing 3,5-dichlorobenzoyl chloride

本发明公开了一种3,5-二氯苯甲酰氯的合成方法，该方法先由苯甲酰氯与三氧化硫进行磺化制得5-氯甲酰间苯二磺酸；再经催化的三光气氯化制得5-氯甲酰间苯二磺酰氯；最后经脱二氧化硫氯化得到3,5-二氯苯甲酰氯。同现行制备方法相比，本发明具有氯化剂稳定、生产安全性高、三废量少、无需回收处理大量危险副产物、粗产品无需精制、生产成本低等特点，适合于工业化生产。

New method for producing 2-acrylamido-2-methylpropanesulfonic acid

FIELD: chemistry. SUBSTANCE: invention relates to a method for producing 2-acrylamido-2-methylpropanesulfonic acid, including following successive stages: 1) mixing acrylonitrile with a compound providing SO 3 selected from fuming sulfuric acid or a mixture of sulfuric acid and fuming sulfuric acid at a temperature of -40 to 30°C for 1 to 120 minutes to obtain a sulfonated mixture; 2) bringing into contact and mixing isobutylene and the sulfonated mixture at a molar ratio of SO 3 and isobutylene ranging from 0.2:1 to 2:1 and a molar ratio of acrylonitrile and isobutylene ranging from 3:1 to 60:1 at a temperature ranging from -40 to 100°C for a period of time ranging from 5 to 300 minutes to obtain a reaction mixture; 3) separating the reaction mixture into a solid/liquid phase and separating solid particles contained in the reaction mixture in the form of a composition 1, in which solid particles make up from 50 to 99% by weight of the composition 1; 4) mixing the composition 1 obtained at stage 3) with an aqueous solution A, which is water or a liquid phase from stage A containing water, acrylonitrile, sulfuric acid and 2-acrylamido-2-methylpropanesulfonic acid or water and 2-acrylamido-2-methylpropanesulfonic acid, for from 10 minutes to 12 hours at a temperature of 5 to 40°C to obtain a suspension 1 of 2-acrylamido-2-methylpropanesulfonic acid; 5) separating the suspension 1 into a solid/liquid phase and separating crystals in the form of a composition 2, in which crystals make up from 40 to 91% by weight of the composition 2. EFFECT: technical result is obtaining a new method for producing 2-acrylamido-2-methylpropanesulfonic acid. 15 cl, 4 ex РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 2 756 196 C2 (51) МПК C07C 303/02 (2006.01) C07C 309/15 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ОПИСАНИЕ ИЗОБРЕТЕНИЯ К ПАТЕНТУ (52) СПК C07C 303/02 (2021.02); C07C 309/15 (2021.02) (21)(22) Заявка: 2019129324, 19.03.2018 (24) Дата начала отсчета срока ...

Filter medium, filter medium manufacturing method, water treatment module and water treatment apparatus

この濾材は、水と油とを含む液体を分離対象とし、前記液体の流路を有する濾材であって、前記流路を構成する基材と、当該流路の少なくとも一部の表面に存在している、一種又は二種以上の含窒素フッ素系化合物とを有する。前記含窒素フッ素系化合物は、分子中に撥油性賦与基と、アニオン型、カチオン型及び両性型からなる群から選択されるいずれか１の親水性賦与基とを含む。 This filter medium is a filter medium that has a liquid flow path as a separation target and contains a liquid containing water and oil, and is present on at least a part of the surface of the base material constituting the flow path. And one or more nitrogen-containing fluorine-based compounds. The nitrogen-containing fluorine-based compound includes an oil repellency-imparting group and any one hydrophilic imparting group selected from the group consisting of an anionic type, a cationic type, and an amphoteric type in the molecule.

Preparation process of fatty acid methyl ester sulfonate

本发明公开了一种脂肪酸甲酯磺酸盐的制备工艺，包括以下步骤：将ME、三氧化硫在干燥空气中磺化，得到的MESA老化，再与醇胺、粘度调节剂混合，中和，得到的脂肪酸甲酯磺酸盐与二氧化氯混合漂白，得到终产物。制备工艺从源头上抑制了二钠盐的生成，提高了产品的质量，得到的产品既可以用于无水的配方体系，也可以用于含水的配方体系，且配方体系的含水量不影响产品的配伍性；中和后产品粘度低，流动性好，出料更容易；不需要加入甲醇降低粘度，工艺更简单，不需要防爆设备，操作者的安全更有保障；漂白工艺温和，温度较低，时间较短，漂白剂用量少，降低能耗物耗；产品为液态，易溶于水，溶解不需要加热。

Preparation of ammonium hydroxyalkyl/alkanoylalkyl sulfonates

A method is disclosed for preparing ammonium hydroxyalkyl sulfonate by a process of reacting ammonium bisulfite and alkylene oxide wherein the pH is maintained at a relatively low value throughout most of the time of the reaction of ammonium bisulfite and alkylene oxide in order to minimize the quantity of impurities, e.g. alkylene glycol and alkanolamine, in the ammonium hydroxyalkyl sulfonate. Ammonium alkanoyl alkyl sulfonates prepared by reacting such ammonium hydroxyalkyl sulfonates with fatty acids form aqueous solutions which are clear at ambient temperatures, and thus are useful as surfactants in clear liquid products. Also disclosed is the prevention of corrosion in metallic reactors used to conduct the fatty acid-ammonium hydroxyalkyl sulfonate reaction by conducting the reaction in the presence of hypophosphorous acid or water soluble salts thereof.

Alicyclic epoxide and preparation method therefor, and method for preparing 2-hydroxyl-4-oxa-5-thia tricyclo[4.2.1.03,7]nonane derivative

본 발명의 목적은 2-히드록시-4-옥사-5-티아트리시클로[4.2.1.0 3,7 ]노난 유도체인 원료로서 유용한 신규한 지환식 에폭시 화합물을 제공하는 것이다. 본 발명의 지환식 에폭시 화합물은 하기 식(1)으로 표시되는 화합물이다. [식에서, R 1 , R 2 , R 3 및 R 4 는 동일하거나 상이하고, 수소 원자, 할로겐 원자, 할로겐 원자를 포함하는 탄소 원자수가 1 내지 6인 임의로 선택되는 알킬기, 또는 임의로 선택되는 히드록시기가 보호기에 의해 보호되면서 할로겐 원자를 포함하는 탄소 원자수가 1 내지 6인 임의로 선택되는 히드록시알킬기이다. R 5 , R 6 및 R 7 은 동일하거나 상이하고, 수소 원자, 할로겐 원자, 할로겐 원자를 포함하는 탄소 원자수가 1 내지 6인 임의로 선택되는 알킬기, 염을 형성하는 임의로 선택되는 카르복실기, 치환된 옥시카르보닐기, 염을 형성하는 임의로 선택되는 설피노기, 치환된 옥시설피닐기, 염을 형성하는 임의로 선택되는 설포기, 치환된 옥시설포닐기, 또는 시아노기이다. Q는 탄소 원자수가 1 내지 3인 하나 또는 두 개의 알킬기에 의해 치환된 임의로 선택되는 메틸렌기, 산소 원자 또는 황 원자이다. n은 1 또는 2이다. X는 할로겐 원자이다. R 1 , R 2 와 에폭시기의 공간상의 위치, R 7 과 S(O) n X기의 공간상의 위치는 각각 엔도 또는 엑소로 임의로 선택된다.]

Crystalline form hydrated with 2-acrylamido-2-methylpropane sulphonic acid.

La presente invención se relaciona con una forma cristalina hidratada del ácido 2-acrilamido-2- metilpropano sulfónico que tiene un diagrama de difracción de rayos X de polvo 2-theta que comprende picos a 10.58°, 11.2°, 12.65°, 13.66°, 16.28°, 18.45°, 20°, 20.4°, 22.5°, 25.5°, 25.88°, 26.47°, 28.52°, 30.28°, 30.8°, 34.09°, 38.19°, 40.69°, 41.82°, 43.74°, 46.04° grados (+/- 0.1°). La presente invención también se relaciona con un método de producción de esta forma de ácido 2- acrilamido-2-metilpropano sulfónico y un método de preparación para una solución acuosa A de una sal de esta forma de ácido 2-acrilamido-2-metilpropano sulfónico y el (co)polímero de esta forma de ácido acrilamido-2- metilpropano sulfónico.

PROCESS FOR THE PREPARATION OF OXYSULFIDE AND FLUORINE DERIVATIVES IN THE PRESENCE OF AN ORGANIC SOLVENT

La présente invention concerne un procédé de préparation d'un dérivé oxysulfuré et fluoré de formule (III) Ea-SO3R (III) comprenant la mise en contact, en présence d'un solvant organique, d'un composé de formule (II) Ea-SOOR (II) - Ea représentant l'atome de fluor ou un groupe ayant de 1 à 10 atomes de carbone choisi parmi les fluoroalkyles, les perfluoroalkyles et les fluoroalkényles ; et - R représentant l'hydrogène, un cation monovalent ou un groupe alkyle ; avec un agent oxydant. The present invention relates to a process for the preparation of an oxysulfide and fluorinated derivative of formula (III) Ea-SO3R (III) comprising bringing into contact, in the presence of an organic solvent, a compound of formula (II) Ea -SOOR (II) - Ea representing the fluorine atom or a group having from 1 to 10 carbon atoms chosen from fluoroalkyls, perfluoroalkyls and fluoroalkenyls; and - R representing hydrogen, a monovalent cation or an alkyl group; with an oxidizing agent.

METHOD FOR PURIFYING ACRYLAMIDO-2-METHYL-2-PROPANE SULFONIC ACID

L’invention concerne un procédé de purification de l’acide acrylamido-2-méthyl-2-propane sulfonique comprenant les étapes successives suivantes :1) préparation d’une suspension de cristaux d’acide acrylamido-2-méthyl-2-propane sulfonique par distillation d’une solution aqueuse d’acide acrylamido-2-méthyl-2-propane sulfonique afin d’obtenir une suspension de cristaux d’acide acrylamido-2-méthyl-2-propane sulfonique,2) isolation des cristaux d’acide acrylamido-2-méthyl-2-propane sulfonique généralement par séparation solide/liquide de ladite suspension afin d’isoler lesdits cristaux d’acide acrylamido-2-méthyl-2-propane sulfonique,caractérisé en ce que l’étape de distillation se fait en continu et à une pression inférieure à la pression atmosphérique. L’invention concerne également un polymère obtenu à partir de cristaux d’acide acrylamido-2-méthyl-2-propane sulfonique ou de ses sels, obtenus selon un tel procédé, ainsi que l’utilisation dudit polymère dans la récupération du pétrole et du gaz, dans le traitement de l’eau, dans le traitement des boues, dans la fabrication du papier, dans la construction, dans l’industrie minière, dans la formulation de produits cosmétiques, dans la formulation de détergents, dans la fabrication du textile, ou dans l’agriculture. The invention relates to a process for the purification of acrylamido-2-methyl-2-propane sulphonic acid comprising the following successive steps: 1) preparation of a suspension of crystals of acrylamido-2-methyl-2-propane sulphonic acid by distillation of an aqueous solution of acrylamido-2-methyl-2-propanesulfonic acid to obtain a suspension of crystals of acrylamido-2-methyl-2-propanesulfonic acid,2) isolation of the acid crystals acrylamido-2-methyl-2-propane sulphonic generally by solid/liquid separation of said suspension in order to isolate said crystals of acrylamido-2-methyl-2-propane sulphonic acid, characterized in that the distillation step is carried out continuously and at sub-atmospheric ...

PROCESS FOR FLUORINATION OF HALIDE COMPOUNDS OF SULFONYL

PROCESS FOR PREPARING TOBIAS ACID OR 2-AMINO-1-NAPHTALENESULPHONIC ACID

Dans ce procédé, on fait réagir en I une solution de 2hydroxy-naphtalène BN dans un solvant organique avec de l'acide chlorosulfonique (C1SO3 H), alcalinise le mélange résultant en III, recueille de ce mélange alcalinisé une phase aqueuse contenant un sel alcalin d'acide 2-hydroxy-1-naphtalènesulfonique AA, qui est aminé en VII pour donner un mélange aqueux de sels alcalin et d'ammoniac d'acide de Tobias, lequel est extrait en X au moyen d'un solvant organique non miscible à l'eau, cependant que la phase aqueuse est acidifiée en XI. Selon l'invention, la réaction en I est effectuée à 0-10 degrés C avec un rapport molaire C1SO3 H/BN de 0,85 à 1,15 avec un temps de séjour de 5 à 120 minutes et le mélange réactionnel de I est transféré dans un récipient de réserve II où il séjourne 5 à 60 minutes à 0-10 degrés C; de plus l'acidification en XI est effectuée à 20-80 degrés C jusqu'à pH de 1,8 à 2,5. On obtient ainsi un acide de Tobias contenant une très faible teneur en 2-aminonaphtalène produit carcinogène. In this process, reacting in I a solution of 2hydroxy-naphthalene BN in an organic solvent with chlorosulfonic acid (C1SO3 H), basifying the resulting mixture in III, collecting from this basified mixture an aqueous phase containing an alkali salt 2-hydroxy-1-naphthalenesulfonic acid AA, which is aminated in VII to give an aqueous mixture of alkali and ammonia salts of Tobias acid, which is extracted in X using an organic solvent immiscible with water, while the aqueous phase is acidified in XI. According to the invention, the reaction in I is carried out at 0-10 degrees C with a C1SO3 H / BN molar ratio of 0.85 to 1.15 with a residence time of 5 to 120 minutes and the reaction mixture of I is transferred to a reserve container II where it remains for 5 to 60 minutes at 0-10 degrees C; further the acidification in XI is carried out at 20-80 degrees C up to pH 1.8 to 2.5. This gives a Tobias acid containing a very low content of 2- ...

Method of producing fluorinated sulfonyl fluoride

FIELD: chemistry. SUBSTANCE: present invention relates to a method of producing fluorinated sulfonyl fluoride which is useful, for example as material for an ion-exchange resin, which involves oxidation of a compound of formula NCS-Q-CH 2 OCO-R BF1 (1a) using an oxidising agent which essentially contains a chlorine atom or bromine atom, resulting in obtaining a compound of formula X A SO 2 -Q-CH 2 OCO-R BF1 (2a), conversion of the X A SO 2 - group to a compound of formula (2a), to a FSO 2 -group, resulting in formation of a compound of formula FSO 2 -Q-CH 2 OCO-R BF1 (2aF), reacting the formula (2aF) compound with fluorine in liquid phase for perfluorination, resulting in obtaining a compound of formula FSO 2 -Q F -CF 2 OCO-R BF1 (3a), and further disintegration of this compound, where Q is a C 2-10 alkyl group, Q F is a group which contains perfluorinated Q, and is a C 2-10 perfluoroalkylene group, X A is a chlorine atom or bromine atom, R BF1 is a C 1-20 -perfluoroalkyl group or a C 1-20 -perfluoroalkyl group which contains an ether oxygen atom. FSO 2 -Q F -COF (4a). EFFECT: novel industrial method of producing an end product with low amount of wastes. 6 cl, 2 ex РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) 2 379 285 (13) C2 (51) МПК C07C C07C C07C C07C C07C 303/22 209/84 303/02 303/16 309/84 (2006.01) (2006.01) (2006.01) (2006.01) (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ, ПАТЕНТАМ И ТОВАРНЫМ ЗНАКАМ (12) ОПИСАНИЕ ИЗОБРЕТЕНИЯ К ПАТЕНТУ (21), (22) Заявка: 2006103265/04, 02.07.2004 (24) Дата начала отсчета срока действия патента: 02.07.2004 (73) Патентообладатель(и): АСАХИ ГЛАСС КОМПАНИ,ЛИМИТЕД (JP) (43) Дата публикации заявки: 10.08.2006 2 3 7 9 2 8 5 (45) Опубликовано: 20.01.2010 Бюл. № 2 (56) Список документов, цитированных в отчете о поиске: WO 02/44138 A1, 06.06.2002. US 4510328 A1, 09.04.1985. SU 1230464 A3, 07.05.1986. CA 2362695 A1, 28.09.2000. 2 3 7 9 2 8 5 R U (86) Заявка PCT: JP 2004/009769 (02.07.2004) C 2 C 2 (85) Дата перевода заявки PCT на ...

PROCESS FOR THE PREPARATION OF OXYSULFIDE AND FLUORINE DERIVATIVES IN THE PRESENCE OF AN ORGANIC SOLVENT

La présente invention concerne un procédé de préparation d'un dérivé oxysulfuré et fluoré de formule (III) Ea-SO3R (III) comprenant la mise en contact, en présence d'un solvant organique, d'un composé de formule (II) Ea-SOOR (II) - Ea représentant l'atome de fluor ou un groupe ayant de 1 à 10 atomes de carbone choisi parmi les fluoroalkyles, les perfluoroalkyles et les fluoroalkényles ; et - R représentant l'hydrogène, un cation monovalent ou un groupe alkyle ; avec un agent oxydant. The present invention relates to a process for preparing an oxysulfurized and fluorinated derivative of formula (III) Ea-SO3R (III) comprising contacting, in the presence of an organic solvent, a compound of formula (II) Ea -SOOR (II) - Ea representing the fluorine atom or a group having 1 to 10 carbon atoms selected from fluoroalkyls, perfluoroalkyls and fluoroalkenyls; and - R representing hydrogen, a monovalent cation or an alkyl group; with an oxidizing agent.

The high-efficiency synthesis method and N-acetylsulfanilyl chloride of N-acetylsulfanilyl chloride

对乙酰氨基苯磺酰氯的高效合成方法及对乙酰氨基苯磺酰氯，属于化工领域。合成方法包括在持续的搅拌作用下：温度10‑20℃的条件下，采用外部空气将1/4‑1/3重量的乙酰苯胺的粉体和1/3‑1/2重量的氯磺酸的雾化液滴分别吹入氯仿至反应釜内气压达到0.3‑0.4MPa，采用内部空气将剩余乙酰苯胺的粉体和剩余雾化液滴分别吹入氯仿得反应液。继续向反应液吹入内部空气的条件下，将反应液加热至50‑55℃磺化反应20‑40min得磺化液，磺化液加热至70‑75℃并添加氯化剂及氯化助剂氯化反应80‑100min。合成速度快、原料反应彻底、氯磺酸用量少、产品收率高。制得对乙酰氨基苯磺酰氯生产快、成本低、品质高。