Process for the manufacture of bis- and polyacetoacetic acid esters

... 1,131,374. Bis- and polyacetoacetic acid esters. FARBWERKE HOECHST A.G. 12 May, 1967 [12 May, 1966], No. 22091/67. Heading C2C. [Also in Division C3] Bis- or polyacetoacetic acid esters are prepared by reacting diketene with an aliphatic, cycloaliphatic, or araliphatic compound containing at least two hydroxy compounds in the absence of a solvent and in the presence of 0À0001% to 1% by weight of 1,4- diaza-(2,2,2)-bicyclo-octane.. Hydroxy compounds with molecular weight up to about 5000 may be used and many are specified and examples describe the use of diethylene glycol, trimethylol-propane, a propoxylated trimethylol-propane, a propoxylated pentaerythritol, branched polyesters of adipic acid, diethylene glycol and trimethylol propane, of adipic acid, phthalic acid, diethylene glycol and trimethylolpropane, and of adipic acid, maleic acid, and dibutylene glycol.

Improvements in and relating to the preparation of trans-1 : 4-cyclohexanedimethanol

... 1:4-Cyclohexanedimethanol containing the trans-isomer in excess of the percentage of trans-isomer present in the 1:4-cyclohexanedicarboxylic acid dialkyl ester from which it is obtained, is prepared by heating the diester (e.g. the dimethyl ester), preferably under superatmospheric pressure and in absence of a catalyst, at a temperature of at least 250 DEG C. (e.g. 280-400 DEG C.) and converting the reaction product to 1:4-cyclohexanedimethanol, e.g. by reduction with hydrogen in presence of copper chromite. Specification 818,157 and U.S.A. Specification 2,917,549 are referred to.

Process for the production of cycloheptane derivatives

A process of producing a mixture of cycloheptane derivatives containing principally monohydroxymethyl cycloheptane comprises the catalytic hydroformylation of cycloheptatriene using a mixture of carbon monoxide and hydrogen in which the molar ratio of carbon monoxide to hydrogen is less than 1 : 1. Advantageously, the products are after hydrogenated to convert any aldehyde formed to alcohol and to decompose the cobalt carbonyl formed. Examples are furnished of processes in which monohydroxymethylheptane and residues containing dihydroxymethylcycloheptane are obtained. The process may be carried out continuously. Specifications 861,979 and 1,003,577 are referred to.

New dichlorés derivatives of the series of the 16@- methyl pregnane, their preparation, their application like drugs and compositions containing them.

VERFAHREN ZUR HERSTELLUNG NEUER DICHLORIERTER DERIVATE AUS DER REIHE DER 16ALPHA -METHYLPREGNANE

PKC-ACTIVATING COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES

... ²The present invention relates to methods of activate an isoform of protein ²kinase C ²(PKC) for the treatment of neurological diseases including Alzheimer's disease ²and ²stroke using cyclopropanated or epoxidized derivatives of mono- and ²polyunsaturated ²fatty acids. The present invention also relates to methods of reducing ²neurodegeneration using cyclopropanated or epoxidized derivatives of mono- and ²²polyunsaturated fatty acids.² ...

Verfahren zur Herstellung von neuen choleretisch wirksamen Verbindungen

Verfahren zur Herstellung von Oxymethylcyclododecan

Verfahren zur Herstellung von Cyclododecylcarbinol

Verfahren zur Herstellung von Mono-(oxymethyl)-cycloheptan

Verfahren zur Herstellung von neuen, choleretisch wirksamen Verbindungen

Verfahren und Vorrichtung zur kontinuierlichen Umesterung von Alkylestern der Dicarbonsäuren mit Glykolen zu Diglykolestern

THE DERIVATIVES [...] 16ALPHA-METHYL-PREGNANE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC COMPOSITIONS CONTAINING THEM.

NEW DERIVATIVES DICHLORES OF the SERIES OF 16A-METHYL PREGNANE, THEIR METHOD OF PREPARATION AND THEIR APPLICATION LIKE DRUGS

NEW USEFUL A-HALOGENOMETHYLPHENETHYLAMINES IN PARTICULAR LIKE INHIBITORS OF THE DECARBOXYLASE OF AROMATIC AMINO ACIDS AND THEIR METHOD OF PREPARATION

LES MEDICAMENTS SELON L'INVENTION SONT DES A-HALOGENOMETHYLPHENETHYLAMINES DE FORMULE GENERALE: (CF DESSIN DANS BOPI) DANS LAQUELLE Y ET R SONT TELS QUE DEFINIS DANS LA REVENDICATION ET CHACUN DES RESTES R, R, R, R ET R EST TEL QUE DEFINI DANS LE TABLEAU CI-DESSOUS: (CF DESSIN DANS BOPI) (CF DESSIN DANS BOPI) ET LEURS SELS ET LEURS ISOMERES OPTIQUES INDIVIDUELS. THE MEDICINAL PRODUCTS ACCORDING TO THE INVENTION ARE A-HALOGENOMETHYLPHENETHYLAMINES OF THE GENERAL FORMULA: (CF DRAWING IN BOPI) IN WHICH Y AND R ARE AS DEFINED IN THE CLAIM AND EACH OF THE REMAINERS R, R, R, R AND R IS AS DEFINED IN THE TABLE BELOW: (CF DRAWING IN BOPI) (CF DRAWING IN BOPI) AND THEIR SALTS AND THEIR INDIVIDUAL OPTICAL ISOMERS.

NEW DERIVATIVES DICHLORES OF the SERIES OF 16A-METHYL PREGNANE, THEIR METHOD OF PREPARATION AND THEIR APPLICATION LIKE DRUGS

IMPROVED CITRAL AND CITRONELLAL DERIVATIVES

Improved citral and citronellal derivatives, and fragrance and flavorings including the derivatives, that have a longer useful shelf life than citral and citronellal and/or fragrances and flavoring including citral and citronellal, are disclosed. In particular, the derivatives maintain the fragrance characteristics of citral and citronellal, while lowering the allergic properties, and lemony flavors and fragrances with a longer shelf-life than citral and citronellal, are disclosed. Also disclosed are methods of making the derivatives, and articles of manufacture including the derivatives. The derivatives replace the aldehyde group in citral or citronellal with a hydroxy group. In one embodiment, the derivatives also replaced one or more double bonds in citral or the double bond in citronellal with a cyclopropyl group, which can be unsubstituted, or substituted with one or two alkyl, preferably methyl, groups, or with an oxirane or thiirane ring, or combinations thereof. The alkyl groups ...

Procédé de préparation d'oxyméthyl-cyclododécane

PKC-ACTIVATING COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES

The present invention relates to methods of activate an isoform of protein kinase C (PKC) for the treatment of neurological diseases including Alzheimer's disease and stroke using cyclopropanated or epoxidized derivatives of mono- and polyunsaturated fatty acids. The present invention also relates to methods of reducing neurodegeneration using cyclopropanated or epoxidized derivatives of mono- and polyunsaturated fatty acids. 1. A method of activating an epsilon isoform of protein kinase C comprising contacting the epsilon isoform of protein kinase C with an effective amount of at least one compound chosen from: a cis-polyunsaturated fatty alcohol in which at least one of the double bonds is replaced by a cyclopropyl group; a cis-polyunsaturated fatty acid in which at least one of the double bonds is replaced by an epoxyl group; a cis-polyunsaturated fatty acid ester in which at least one of the double bonds is replaced by an epoxy group; a cis-polyunsaturated fatty alcohol in which at least one of the double bonds is replaced by an epoxyl group; a cis-monounsaturated fatty acid in which the double bond is replaced by a cyclopropyl group; a cis-monounsaturated fatty acid ester in which the double bond is replaced by a cyclopropyl group; and a cis-monounsaturated fatty alcohol in which the double bond is replaced by a cyclopropyl group.23-. (canceled)4. The method of claim 1 , wherein the at least one compound is a cis-polyunsaturated fatty alcohol in which at least one of the double bonds is replaced by a cyclopropyl group and the polyunsaturated fatty acid from which the fatty alcohol is derived is chosen from arachidonic acid claim 1 , docosapentaenoic acid claim 1 , docosahexaenoic acid claim 1 , eicosapentaenoic acid claim 1 , linoleic acid claim 1 , γ-linoleic acid claim 1 , α-linolenic acid claim 1 , eicosatetraenoic acid claim 1 , adrenic acid claim 1 , and derivatives thereof.510-. (canceled)11. The method of claim 1 , wherein the at least one compound is ...

Cyclopentanbutanolderivate als Duftstoffe

Verfahren zur Umlagerung von cis-ª‰-Dekahydronaphtholen in ihre trans-Isomeren

Pregnane compounds

Novel 9 alpha ,11 beta -dichloro-16 alpha -methyl- DELTA 1,4-pregnadiene 3,20-diones of the formula I wherein R is selected from the group consisting of trimethylsilylphenyl, cyclododecyloxy, dicyclopentylmethoxy and cyclohexylmethoxy having a suprising "in loco" anti-inflammatory activity limited to place of inflammation without systemic effects and a process for their preparation.

IMPROVED CITRAL AND CITRONELLAL DERIVATIVES

2.2.3 it [...] derivatives, fragrance composition, use thereof and methods of making the said composition and to enhance, enhance or modify the fragrance of a fragrance composition or fragrance delivery

ORGANIC COMPOUNDS

PKC-ACTIVATING COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES

The present invention relates to methods of activating an isoform of protein kinase C (PKC) for the treatment of neurological diseases including Alzheimer's disease and stroke using cyclopropanated or epoxidized derivatives of mono- and polyunsaturated fatty acids. The present invention also relates to methods of reducing neurodegeneration using cyclopropanated or epoxidized derivatives of mono- and polyunsaturated fatty acids.

New alcohols derived from the éthano-9, 10 dihydro-9, 10 anthracene and method of preparation

IMPROVED CITRAL AND CITRONELLAL DERIVATIVES

Improved citral and citronellal derivatives, and fragrance and flavorings including the derivatives, that have a longer useful shelf life than citral and citronellal and/or fragrances and flavoring including citral and citronellal, are disclosed. In particular, the derivatives maintain the fragrance characteristics of citral and citronellal, while lowering the allergic properties, and lemony flavors and fragrances with a longer shelf-life than citral and citronellal, are disclosed. Also disclosed are methods of making the derivatives, and articles of manufacture including the derivatives. The derivatives replace the aldehyde group in citral or citronellal with a hydroxy group. In one embodiment, the derivatives also replaced one or more double bonds in citral or the double bond in citronellal with a cyclopropyl group, which can be unsubstituted, or substituted with one or two alkyl, preferably methyl, groups, or with an oxirane or thiirane ring, or combinations thereof. The alkyl groups ...

Organic compounds

PROCEDURE FOR the PRODUCTION of NEW of DICHLORIERTER DERIVATIVES FROM the NUMBER of the 16ALPHA - METHYLPREGNANE

Procedure for the production of until and Polyacetessigsäureestern

PROCEDURE FOR the PRODUCTION of NEW of DICHLORIERTER DERIVATIVES FROM the NUMBER of the 16ALPHA - METHYLPREGNANE

DICHLORO DERIVATIVES OF 16ALPHA-METHYL PREGNANES

NOUVEAUX DERIVES DICHLORES DE LA SERIE DU 16A-METHYL PREGNANE, LEUR PROCEDE DE PREPARATION ET LEUR APPLICATION COMME MEDICAMENTS

LA PRESENTE DEMANDE A POUR OBJET LES PRODUITS DE FORMULE I: (CF DESSIN DANS BOPI) DANS LAQUELLE RTRIMETHYLSILYLPHENYL, CYCLODODECYLOXY, DICYCLOPENTYLMETHOXY OU CYCLOHEXYLMETHOXY, LEUR PROCEDE DE PREPARATION ET LEUR APPLICATION COMME MEDICAMENTS.

NOUVELLES A-HALOGENOMETHYLPHENETHYLAMINES UTILES NOTAMMENT COMME INHIBITEURS DE LA DECARBOXYLASE DES AMINOACIDES AROMATIQUES ET LEUR PROCEDE DE PREPARATION

LES MEDICAMENTS SELON L'INVENTION SONT DES A-HALOGENOMETHYLPHENETHYLAMINES DE FORMULE GENERALE: (CF DESSIN DANS BOPI) DANS LAQUELLE Y ET R SONT TELS QUE DEFINIS DANS LA REVENDICATION ET CHACUN DES RESTES R, R, R, R ET R EST TEL QUE DEFINI DANS LE TABLEAU CI-DESSOUS: (CF DESSIN DANS BOPI) (CF DESSIN DANS BOPI) ET LEURS SELS ET LEURS ISOMERES OPTIQUES INDIVIDUELS.

Preparation of cyclopentane carboxaldehydes and derivatives thereof

Organic compounds

PREGNANE COMPOUNDS

Synthesis of organic oxygen-containing compounds

Oxygen containing compounds, mainly aldehydes, are prepared by reacting an olefinic compound, carbon monoxide, and hydrogen at a pressure above 300 atmospheres (preferably 325-1500 atmospheres) in presence of a hydrogenation catalyst, and at a reaction temperature of 75-250 DEG C. The molar ratio of carbon monoxide to hydrogen may vary from 1 : 1.5 to 1 : 10, and the catalyst may be one containing nickel, cobalt, iron, copper, or ruthenium, promoted with thoria or manganese. A solvent such as water (when unsaturated aldehydes are obtained), or cyclohexane, xylene, methyl formate, or diethyl ether may be employed. The reaction vessel may be an autoclave or tubular reactor (in which temperature and pressure may not be uniform), and may be lined with silver, copper, metals which react to give carbonyls, glass, porcelain or inert metals. The reaction may be batchwise or continuous. Olefinic compounds specified are ethylene, propylene, butene-2, isobutylene, pentene-1, tetramethyl ethylene, ...

Opsin-binding ligands, compositions and methods of use

Compounds are disclosed that are useful for treating ophthalmic conditions caused by or related to production of toxic visual cycle products that accumulate in the eye, such as dry adult macular degeneration, as well as conditions caused by or related to the misfolding of mutant opsin proteins and/or the mis-localization of opsin proteins. Compositions of these compounds alone or in combination with other therapeutic agents are also described, along with therapeutic methods of using such compounds and/or compositions. Methods of synthesizing such agents are also disclosed.

Opsin-binding ligands, compositions and methods of use

Compounds are disclosed that are useful for treating ophthalmic conditions caused by or related to production of toxic visual cycle products that accumulate in the eye, such as dry adult macular degeneration, as well as conditions caused by or related to the misfolding of mutant opsin proteins and/or the mis-localization of opsin proteins. Compositions of these compounds alone or in combination with other therapeutic agents are also described, along with therapeutic methods of using such compounds and/or compositions. Methods of synthesizing such agents are also disclosed.

PROCESS FOR PREPARING NEW DICHLORINATED DERIVATIVES OF THE 16.alpha.-METHYL PREGNANE SERIES

Cyclopentenebutanol derivatives

The invention relates to compounds of the general formula wherein R1 to R3 and R6 are H, methyl or ethyl, R4 is methyl or ethyl, or R1+R2 form -C(H2)n-, with n being 3 or 4 and the use of these compounds as an odorant or as an ingredient of an odorant composition.

VERFAHREN ZUR HERSTELLUNG VON ALPHA, ALPHA-DIALKYLPERHYDROBENZYLALKOHOLEN

Pharmaceutical compositions comprising a propanol derivative

... 1 - Cyclohexyl - 2 - methyl - 1 - propanol is prepared by reacting cyclohexyl chloride with magnesium in ether to form a solution of cyclohexyl magnesium chloride which is reacted with iso-butyraldehyde at - 10 DEG C. to produce the required compound on hydrolysis of the Grignard complex formed.ALSO:Pharmaceutical compositions having choleretic and sedative action comprise a solid diluent or carrier and 1-cyclohexyl-2-methyl-1-propanol. They may be in the form of gelatine-coated pills containing 400 mg. of the active compound.

PREGNANE COMPOUNDS

Cyclopentenyl carbinols

Verfahren zur Herstellung von Cyclohexylaethylalkohol

Verfahren zur Herstellung von reinem cis- und reinem trans-1, 4-Cyclohexandimethylol-bis-chlorkohlensaeureester

NEUE DICHLORDERIVATE DER 16(ALPHA)-METHYLPREGNANREIHE, DEREN HERSTELLUNG, DEREN VERWENDUNG ALS ARZNEIMITTEL UND DIE SIE ENTHALTENDEN ZUSAMMENSETZUNGEN

Novel halogenated cycloalkylethers

Compounds of the general formula in which each of the X radicals, which may be the same or different, represents a fluorine or chlorine atom, n is 0 or 1 and m is 1, 2 or 3, are used as sealing adjuvants for films of polymers of trifluorochloroethylene. In an example various compounds of the above general formula are used as sealing adjuvants for a thermoplastic film made of a copolymer of trifluorochloroethylene and vinylidine fluoride. Films made from other polymers, e.g. homopolymeric trifluorochloroethylene and copolymers of trifluorochloroethylene with vinyl chloride, 1,1-chlorofluoroethylene, trifluoroethylene and perfluorobutadiene may be similarly treated.ALSO:The invention comprises halogenated cycloalkylethers of the general formula in which the X radicals may be the same or different and are fluorine or chlorine; n is 0 or 1; and m is 1, 2 or 3. They may be prepared by chlorinating a halogenated ether of formula in the ...

Method of preparation of the 7-cyclohexylheptanol-1 and the 7-phénylheptane diol-1, 4

New amino-ethers derived from the éthano-9, 10 dihydro-9, 10 anthracene and their salts, and proceeded of preparation

PKC-ACTIVATING COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES

The present invention relates to methods of activate an isoform of protein kinase C (PKC) for the treatment of neurological diseases including Alzheimer's disease and stroke using cyclopropanated or epoxidized derivatives of mono- and polyunsaturated fatty acids. The present invention also relates to methods of reducing neurodegeneration using cyclopropanated or epoxidized derivatives of mono- and polyunsaturated fatty acids. 151.-. (canceled)52. A method of treating multiple sclerosis , comprising administering to a patient in need thereof an effective amount of a cyclopropanated polyunsaturated fatty acid (PUFA) ester wherein at least one carbon-carbon unsaturated bond in said PUFA is cyclopropanated.53. The method of claim 52 , wherein the ester is a methyl ester.54. The method of claim 52 , wherein all carbon-carbon unsaturated bonds in said PUFA are cyclopropanated.55. The method of claim 52 , wherein said PUFA is selected from the group consisting of lineoleic acid claim 52 , γ-linolenic acid claim 52 , α-linolenic acid claim 52 , arachidonic acid claim 52 , eicosapentaenoic acid claim 52 , eicosatetraenoic acid claim 52 , docosapentaenoic acid claim 52 , docosahexaenoic acid claim 52 , stearidonic acid claim 52 , and adrenic acid. This is a continuation application of U.S. application Ser. No. 16/400,132, filed May 1, 2019, which is a continuation application of U.S. application Ser. No. 14/803,762, filed Jul. 20, 2015, now U.S. Pat. No. 10,323,011, which is a divisional application of U.S. application Ser. No. 13/401,459, filed Feb. 21, 2012, now U.S. Pat. No. 9,119,825, which is a continuation application of U.S. application Ser. No. 12/510,681, filed Jul. 28, 2009, now U.S. Pat. No. 8,163,800, which claims the benefit of U.S. Provisional Application No. 61/084,172, filed Jul. 28, 2008, all of which are incorporated herein by reference.The present invention relates to compositions and methods to activate an isoform of protein kinase C (PKC). The present ...

Verfahren zur Herstellung von Aldehyden durch die Oxosynthese und Katalysator hierfuer

Process for the manufacture of hydroxymethylcyclododecane

Hydroxymethylcyclododecane is the main product and dihydroxymethylcyclododecane the by product, of reacting cyclododecatriene with CO and H2 in presence of the usual oxosynthesis catalysts, e.g. cobalt acetate or naphthenate, the molar ratio CO : H2 being less than 1 : 1. Preferably the reaction is carried out in a solution of an aliphatic alcohol or ethyl acetate and the reaction mixture is subjected to an after-hydrogenation. French Specification 889,023 and Specifications 861,979, 1,003,577 are referred to.

PROCESS FOR PREPARING NEW DICHLORINATED DERIVATIVES OF THE 16.alpha.-METHYL PREGNANE SERIES

La présente demande a pour objet un procédé pour la préparation des produits de formule (I): . < IMG > dans laquelle R = triméthylsilylphényl, cyclododécyloxy, dicyclopentylméthoxy ou cyclohexylméthoxy. Les produits de formule (I) peuvent être utilises comme médicaments, notamment anti inflammatoires "in loco".

ALPHA - HALOGENMETHYLAMIN-DERIVATE UND VERFAHREN ZU DEREN HERSTELLUNG

Obtaining colourless depolymerisation products from

Practically colourless depolymerisation products are obtained from scrap polyesters of structure where R is radical obtained after elimination of COOH gps. from a difunctional carboxylic acid radical and R' is radical obtained after eliminating OH gps. from a bifunctional glycol. In the process, the polyester is heated in the presence of a C1-C10 aliphatic alcohol at temp. >125 deg.C. and then catalytically hydrogenated at 50 deg. to 300 deg.C. and at a press. up to 35 Mpa until a colourless product was formed. Pure colourless materials are easily obtained from scrap polyesters by an expensive method.

a-Halomethylaminoacids and their preparation

Compounds of formula I wherein X1 and X2 are each hydrogen or fluorine; R1 is hydrogen, alkylcarbonyl, alkoxycarbonyl or aminoalkylcarbonyl, and three of R2, R3, R4, R5 and R6 are hydrogen, the others being selected from hydroxy, methyl and methoxy. Also disclosed is a process of preparing compounds of formula I in which R1 and X2 are hydrogen and X1 is fluorine and R2, R3, R4, R5 and R6 are various combinations of hydrogen, methyl, ethyl, tert-butyl, halogen, trifluoromethyl, hydroxy, methoxy and methylene dioxy by reacting a corresponding benzyl magnesium halide with fluoroacetonitrile and reducing the resultant ketimine salt.

ALPHA-HALOMETHYL AMINES

PKC-ACTIVATING COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES

The present invention re-lates to methods of activate an isoform of protein kinase C (PKC) for the treatment of neurological diseases including Alzheimer's disease and stroke using cy-clopropanated or epoxidized derivatives of mono- and polyunsaturated fatty acids The present invention also relates to methods of reducing neurodegenera-tion using cyclopropanated or epoxi-dized derivatives of mono- and polyun-saturated fatty acids ...

OPSIN-BINDING LIGANDS, COMPOSITIONS AND METHODS OF USE

Compounds are disclosed that are useful for treating ophthalmic conditions caused by or related to production of toxic visual cycle products that accumulate in the eye, such as dry adult macular degeneration, as well as conditions caused by or related to the misfolding of mutant opsin proteins and/or the mis-localization of opsin proteins. Compositions of these compounds alone or in combination with other therapeutic agents are also described, along with therapeutic methods of using such compounds and/or compositions. Methods of synthesizing such agents are also disclosed.

Method of preparation of polyesters of the acétyl-acetic acid

New cycloalkyléthers halogenous and their method of preparation

Process for the manufacture of bis- and polyacetoacetic acid esters

Organic hydroxy compound and derivatives thereof

Cyclopentanbutanolderivate als Duftstoffe

Process for the production of 1,4-cyclohexanedimethylene-bis-chlorocarbonate

The invention comprises trans- and/or cis-1,4-cyclohexanedimethylene -bischlorocarbonate, which may be made by reaction of 1,4-cyclohexanedimethylol with phosgene. A mixture of trans-and cis-1,4-cyclohexanedimethylol is introduced into liquid phosgene and a mixture of the trans-and cis-chlorocarbonates is formed. After a short time trans-1,4-cyclohexanedimethylene-bis-chlorocarbonate crystallises out and the liquid cis-form may subsequently be obtained from the solution by evaporating the phosgene. The two isomers may be saponified with water or alkali to form very pure isomeric 1,4-cyclohexanedimethylols, or may be reacted with alcohols, amines and phenols to form esters of carbonic acid and of urethanes. A detailed example is given.

Preparation of oxygenated compounds by carbonylation of olefins

Oxygenated compounds are prepared by the carbonylation of olefines at elevated temperature and pressure in the presence of a carbonylation catalyst and of an acetalisation agent consisting of an olefinic oxide or a polyhydric alcohol, the acetal which is formed being withdrawn from the carbonylation zone. Suitable olefines are, for example, propylene, pentene-1, hexene-1, octene-1, cyclohexene, nonene and tetrapropylene. The preferred conditions for carrying out the process are a temperature of 265-320 DEG F. and a pressure of 3000-4000 psig. The products are mainly acetals and alcohols. The acetals formed may be hydrolysed to give the corresponding aldehydes which may be hydrogenated or oxidised by known methods to give alcohols or acids respectively. Suitable acetalisation agents are, for example, ethylene glycol, propylene glycol-1.2, propylene glycol1.3, butane-diol-1.4, glycerin, ethylene oxide and propylene oxide. It is desirable that all reactants should be substantially free of ...

Opsin-binding ligands, compositions and methods of use

Compounds are disclosed that are useful for treating ophthalmic conditions caused by or related to production of toxic visual cycle products 5 that accumulate in the eye, such as dry adult macular degeneration, as well as conditions caused by or related to the misfolding of mutant opsin proteins and/or the mis-localization of opsin proteins. Compositions of these compounds alone or in combination with other therapeutic agents are also described, along with thereapeutic methods of using such compounds and/or 10 compositions. Methods of synthesizing such agents are also disclosed.

Improvements in or relating to vinylation of tertiary alcohols

A catalyst for the conversion of tertiary alcohols to their vinyl ethers by reaction with acetylene (see Group IV(b)) comprises an alkali metal alkoxide promoted with an oxide of an alkaline earth metal or of magnesium.ALSO:Vinyl ethers of tertiary alcohols are prepared by reacting together, in the liquid phase at a temperature of from 100 DEG C. to 250 DEG C. and at an elevated pressure of up to 500 p.s.i.g. in the presence of a catalyst comprising an alkali metal alkoxide and an oxide of an alkaline earth metal or of magnesium, acetylene and a tertiary alcohol of formula wherein the R groups may be the same or different and represent alkyl, aryl, aralkyl, alkaryl or cycloalkyl radicals or two R groups together with the tertiary carbon atom form a cycloalkyl group. The alkoxide catalyst may be derived from any primary, secondary or tertiary alcohol. An inert solvent may be present. In Examples (1) and (3) potassium is reacted with excess tertbutanol and the resultant ...

A method for the purification of polyhydric alcohols such as trimethylolpropane and similar higher alcohols

In a process for the purification of a polyhydric alcohol containing at least three methylol groups per molecule by fractional distillation under reduced pressure, the crude alcohol is purified, e.g. by treatment with an ion-exchange material, before it is submitted to distillation. The process is particularly suitable for the purification of 1,1,1-trimethylol-propane obtained by reacting formaldehyde with butyraldehyde in the presence of alkali. The reaction product is evaporated to a high degree, and alkali formate crystals are then separated from the alcohol by centrifuging. After treatment with ion-exchange material, the alcohol is sumitted to batch distillation at a temperature of not more than 180-190 DEG C. using a column maintained at a pressure of 5 mm. Hg or less. Two prefractions are distilled over, and then the main alcohol fraction is collected while the refractive index of the distillate is between 1.467 and 1.469. The prefractions and afterfraction may be returned to the ...

Anthracene derivatives and their preparation

... 1,146,488. 9,10 - Ethano - 9,10 - dihydroanthracene derivatives. SOC. INDUSTRIELLE POUR LA FABRICATION DES ANTIBIOTIQUES. 27 June, 1966 [1 July, 1965; 8 July, 1965; 7 Oct., 1965], No. 28748/66. Heading C2C. Novel compounds of Formula (I), in which n is 0, 1 or 2, R is hydrogen or methyl (when n is 2, R can only be hydrogen), A is C 2-4 alkylene and each of R 1 and R 2 is hydrogen or C 1-4 alkyl or -NR 1 R 2 represents a pyrrolidino, piperidino, morpholino or hexamethyleneimino ring, and acid-addition and quaternary ammonium salts thereof, are prepared by (a) reacting a compound of Formula (II) with a compound of Formula (III), in which X is halogen, benzenesulphonyl, toluenesulphonyl or methanesulphonyl, in the presence of an alkaline agent capable of combining with the acid formed during the reaction, or (b) heating anthracene with a compound of Formula (IV) and, if desired, forming an acid-addition or quaternary ammonium salt of a resulting compound. 1 - Dimethylamino - 2 - allyloxypropane ...

DICHLORO DERIVATIVES OF 16ALPHA-METHYL PREGNANES

Verfahren zur Herstellung von Carbonylverbindungen durch die Oxo-Synthese

Improved citral and citronellal derivatives

CARBINOLS HAVING OLFACTORY PROPERTIES REMINISCENT OF PATCHOULI OIL

The present invention refers to carbinols of formula (I), wherein R1 and R2 are independently selected from methyl and ethyl; R3 is selected from C1-C3 alkyl and cyclopropyl; R4 is selected from C3 alkyl and cyclopropyl; R5 is hydrogen or methyl; and the dotted line represents a single bond or no bond. The invention further refers to their preparation, and to perfume compositions and fragrance applications comprising them.

ORGANIC COMPOUNDS

ORGANIC COMPOUNDS

Described are 2,2,3-trimethylcyclopentane derivatives of formula (1) wherein R1 is methyl or ethyl; and R2 is hydrogen, methyl or ethyl. The invention furthermore relates to a method of their production a to fragrance compositions comprising them.

Verfahren zur Herstellung eines hauptsaechlich Monooxymethylcyclododecan enthaltenden Gemisches von Cyclododecanderivaten

Opsin-binding ligands, compositions and methods of use

Compounds are disclosed that are useful for treating ophthalmic conditions caused by or related to production of toxic visual cycle products 5 that accumulate in the eye, such as dry adult macular degeneration, as well as conditions caused by or related to the misfolding of mutant opsin proteins and/or the mis-localization of opsin proteins. Compositions of these compounds alone or in combination with other therapeutic agents are also described, along with thereapeutic methods of using such compounds and/or 10 compositions. Methods of synthesizing such agents are also disclosed.

Steroids

Novel 9α,11β-dichloro-16α-methyl-Δ1,4 -pregnadiene 3,20-diones of the formula см. иллюстрацию в PDF-документе wherein R is selected from the group consisting of trimethylsilylphenyl, cyclododecyloxy, dicyclopentylmethoxy and cyclohexylmethoxy having a suprising "in loco" anti-inflammatory activity limited to place of inflammation without systemic effects and a process for their preparation.

Cyclopentanbutanolderivate

ORGANIC COMPOUNDS

Described are 2,2,3-trimethylcyclopentane derivatives of formula (1) wherein R1 is methyl or ethyl; and R2 is hydrogen, methyl or ethyl. The invention furthermore relates to a method of their production a to fragrance compositions comprising them.

Verfahren zur Carbonylierung einer Cycloalkenverbindung mit einer funktionellen Gruppe

PKC-ACTIVATING COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES

The present invention relates to methods of activate an isoform of protein kinase C (PKC) for the treatment of neurological diseases including Alzheimer's disease and stroke using cyclopropanated or epoxidized derivatives of mono- and polyunsaturted fatty acids. The present invention also relates to methods of reducing neurodegeneration using cyclopropanated or epoxidized derivatives of mono and polyunsaturated fatty acids. 151.. (canceled)54. A pharmaceutical composition comprising methyl-3-(2-((2-((2-((2-((2-((2-ethylcyclopropyl)methyl)cyclopropyl)methy-1)cyclopropyl)methyl)-cyclopropyl)methyl)cyclopropyl)methyl)cyclopropyl)propanoate or a pharmaceutically acceptable salt thereof , and a pharmaceutically acceptable carrier.56. A method of treating a neurological disease selected from the group consisting of Alzheimer's disease , multiple sclerosis , and stroke comprising administering to a patient in need thereof methyl-3-(2-((2-((2-((2-((2-((2-ethylcyclopropyl)methyl)cyclopropyl)methy-1)cyclopropyl)methyl)-cyclopropyl)methyl)cyclopropyl)methyl)cyclopropyl)propanoate or a pharmaceutically acceptable salt thereof.57. The method of wherein the neurological disease is Alzheimer's disease.58. The method of wherein the neurological disease is multiple sclerosis.59. The method of wherein the neurological disease is stroke. This is a continuation application of U.S. Application No. 14/803,762, filed Jul. 20, 2015, which is a divisional application of U.S. application Ser. No. 13/401,459, filed Feb. 21, 2012, now U.S. Pat. No. 9,119,825, which is a continuation of U.S. application Ser. No. 12/510,681, filed Jul. 28, 2009, now U.S. Patent No. 8,163,800, which claims the benefit of U.S. Provisional Application No. 61/084,172, filed Jul. 28, 2008, all of which are incorporated herein by reference.The present invention relates to compositions and methods to activate an isoform of protein kinase C (PKC). The present invention also provides methods for reducing ...

Neue vom 9,10-AEthano-9,10-dihydroanthracen abgeleitete Aminoaether und deren Salze sowie Verfahren zu ihrer Herstellung

Oxidation Catalyst for Hydrocarbon Compound, and Method and Apparatus for Producing Oxide of Hydrocarbon Compound Using Same

According to the first embodiment of the present invention, an oxide of a hydrocarbon compound can be produced with high yield and high productivity by oxidizing the hydrocarbon compound with molecular oxygen in the co-presence of an N-hydroxy compound, such as methyl ethyl ketone or N-hydroxysuccinimide, and a phosphate ester, such as dibutyl phosphate. According to another embodiment of the present invention, an oxide of a hydrocarbon compound can be produced with high yield by using an oxidation catalyst that comprises an oxime compound, such as methyl ethyl ketone. According to another embodiment of the present invention, an alcohol and/or a ketone can be produced with high yield by oxidizing the hydrocarbon compound at a temperature of 160° C. or less, and by decomposing the resulting hydroperoxide, for example, in a unit having an inner surface formed by a material from which no transition metal ion is generated.

CHIRAL INTERMEDIATES USEFUL FOR THE PREPARATION OF HYDROXYPHOSPHINE LIGANDS

A compound of formula (I), wherein Ris hydrogen or a hydroxyl protecting group; and Rand Rare same or different and are independently selected from halogen or —O—SO—X; wherein X is —C-Calkyl; C-Calkyl substituted with one or more halogen; or substituted or unsubstituted phenyl wherein said phenyl substituent is selected from halogen, nitro and C-Calkyl; provided that when Ris bromine, X is not p-toluoyl; and a process for the preparation thereof. 3. The compound as claimed in claim 2 , wherein said hydroxyl protecting group is selected from Z or —SO—X.4. The compound as claimed in or claim 2 , wherein Rand Rare same or different and are independently selected from halogen or —O—SO—X provided that when Ris bromine claim 2 , X is not p-toluoyl.5. The compound as claimed in or claim 2 , wherein X is selected from C-Calkyl; C-Calkyl substituted with one or more halogen; and substituted or unsubstituted phenyl wherein said phenyl substituent is selected from halogen claim 2 , nitro and C-Calkyl.7. The compound as claimed in claim 4 , wherein said Rand Rare same or different and are independently selected from F claim 4 , Cl claim 4 , Br claim 4 , I or —O—SO—X.8. The compound as claimed in claim 7 , wherein X is selected from methyl claim 7 , trifluoromethyl claim 7 , n-novafluorobutyl claim 7 , 2 claim 7 ,2 claim 7 ,2-trifluoroethyl claim 7 , p-toluoyl claim 7 , p-nitrophenyl and p-bromophenyl.10. The compound as claimed in or claim 7 , wherein Rand Rare same or different and are independently selected from F claim 7 , Cl claim 7 , Br and I.11. The compound as claimed in or or claim 7 , wherein Z is selected from tetrahydro-2H-pyran-2-yl; tetrahydro-2H-pyran-2-one-3-yl; tetrahydro-2H-pyran-2-methoxy-6-yl and tetrahydro-2H-pyran-2-ethoxy-6-yl.13. Use of a compound as claimed in any preceding claim as an intermediate for the preparation of a hydroxyphosphine ligand.1515. Use of a hydroxyphosphine ligand as a co-catalytic ligand for the enantioselective preparation of a ...

Process for preparing 4-cyclohexyl-2-methyl-2-butanol

Process for preparing 4-cyclohexyl-2-methyl-2-butanol The present invention relates to a process for preparing 4-cyclohexyl-2-methyl-2-butanol. The process comprises the following steps: a) reaction of styrene with isopropanol at elevated temperature to obtain 4-phenyl-2-methyl-2-butanol, and b) heterogeneously catalyzed hydrogenation of 4-phenyl-2-methyl-2-butanol over a catalyst suitable for ring hydrogenation of aromatics.

NOVEL ALICYCLIC ALCOHOL

Provided is an alicyclic alcohol compound which can be used as a raw material for a compound perfume, and which has excellent floral-green-like aromas which are crisp and fresh; also provided are a manufacturing method for the same, and a perfume composition which contains the alicyclic alcohol compound. An alicyclic alcohol compound having a specified structure represented by chemical formula (1) has excellent floral-green-like aromas which are crisp and fresh; and a method for manufacturing the alicyclic alcohol compound represented by chemical formula (1) by reacting, in the presence of hydrogen fluoride, 4-isopropyl-1-methylcyclohexene and carbon monoxide, isomerising the resulting 4-isopropyl-1-methylcyclohexane carboxylic acid fluoride, thus making 2-methyl-2-(4-methylcyclohexyl)-propionyl fluoride, reacting with alcohol and acquiring a cyclohexane carbonyl compound, and then reducing the cyclohexane carbonyl compound. The present invention relates to an alicyclic alcohol compound which can be used as a raw material for compounded perfumes, a method for manufacturing the same, and a perfume composition containing said alicyclic alcohol compound.It is known that some of alicyclic alcohol compounds are useful for a raw material for compounded perfumes. For example, Non-patent Document 1 discloses that Mayol having green and muguet-like fragrance, Mugetanol having muguet-like light floral fragrance, Patchone having patchouli-like woody fragrance and the like are useful as a raw material for compounded perfumes.The object of the present invention is to provide a novel alicyclic alcohol compound having floral-green-like fragrance useful for a raw material for compounded perfumes, a method for manufacturing the same and a perfume composition containing said alicyclic alcohol compound.As a result of synthesizing various compounds and studying fragrances thereof, the present inventors have found that the alicyclic alcohol compound represented by the following chemical ...

Synthesis of a novel odorant

A novel odorant of formula (I) wherein each of R 1 , R 2 , R 3 , R 3 , R 5 , R 6 , R 7 , R 8 , R 9 and R 10 are independently selected from H, CH 3 , and C 2 H 5 ; X is selected from —CH 2 OH, —CH 2 OCOCH 3 and —CHO, n is selected from 0 and 1. The dotted line represents double bond or single bond.

Modifying Cementitious Compositions Using Ketone Alcohol Oil Waste

The present invention relates to modification of hydratable cement and cementitious materials, such as mortar cement and masonry or ready-mix concrete using ketone alcohol oil waste (“KAOW”) material, obtained as an alkali-soluble liquor waste byproduct at a certain stage in the commercial production of cyclohexanol and cyclohexanone. Preferred applications for KAOW are in chemical admixture formulations whereby KAOW is used to substitute for a portion of a cement dispersant such as sodium lignosulfonate, sodium gluconate, or other conventional dispersant. Another preferred use is in mortar cement and masonry concrete units such as blocks, pavers, curbstones, and other concrete masonry units wherein air void systems advantageously foster freeze-thaw durability.

OPEN-FLASK HYDROBORATION AND THE USE THEREOF

The present disclosure generally relates to a process for hydroboration of an alkene or alkyne using ammonia borane (AB). In particular, the present invention relates to hydroboration of an alkene or alkyne in the presence of air or moisture, and a clean process for facile preparation of an alcohol by oxidizing the organoborane so formed with hydrogen peroxide. The products, including aminodialkylboranes, ammonia trialkylborane complexes, as well as various alcohols so prepared, are within the scope of this disclosure. 1. A process for hydroboration of an alkene or alkyne , comprising the steps ofa. preparing a solution of an ammonia borane (AB);b. adding an alkene or alkyne to said AB solution; andc. refluxing with heating and stirring to afford an organoborane, wherein the effectiveness of this process is not affected by the presence of air or moisture.2. The process of claim 1 , wherein the solution of an ammonia borane is prepared using an ethereal solvent.3. The process of claim 2 , wherein said ethereal solvent is THF (tetrahydrofuran).4. The process of claim 1 , wherein the solution of an ammonia borane in THF has a concentration of about 0.5˜2 M (moles/liter).5. The process of claim 1 , wherein said refluxing is performed at about 90° C.6. The process of claim 1 , wherein said alkene or alkyne is part of an aromatic molecule claim 1 , an aliphatic molecule claim 1 , or a combination thereof.7. The process of claim 1 , wherein said alkene or alkyne is part of a cyclic structure claim 1 , a linear structure claim 1 , or a combination thereof.8. The process of claim 1 , wherein the molar ratio of said AB to said alkene or alkyne ranges from about 2 to about 0.2.9. An aminodialkylborane or ammonia-trialkylborane complex prepared according to the process ofa. preparing a solution of an ammonia borane (AB);b. adding an alkene or alkyne to said AB solution; andc. refluxing with heating and stirring to afford an organoborane, wherein the effectiveness of this ...

Cyclopropane compound

where R1 is a methyl group and R2 is a methyl group, or R1 is a hydrogen atom and R2 is an ethyl group.

Opsin-Binding Ligands, Compositions and Methods of Use

Compounds are disclosed that are useful for treating ophthalmic conditions caused by or related to production of toxic visual cycle products that accumulate in the eye, such as dry adult macular degeneration, as well as conditions caused by or related to the misfolding of mutant opsin proteins and/or the mis-localization of opsin proteins. Compositions of these compounds alone or in combination with other therapeutic agents are also described, along with therapeutic methods of using such compounds and/or compositions. Methods of synthesizing such agents are also disclosed.

VDR-SILENT VITAMIN D DERIVATIVE AS INHIBITORS OF SREBP AND PHARMACEUTICAL USE THEREOF

Provided are vitamin Dderivatives of formula (I), pharmaceutical compositions thereof, and pharmaceutical or medical uses thereof for treating metabolic disease, a liver disease, obesity, diabetes, cardiovascular disease, or cancer in a patient in need thereof. 2. (canceled)4. (canceled)5. The Compound of claim 1 , wherein one Ris hydrogen and the other Rare independently hydrogen claim 1 , alkyl claim 1 , haloalkyl claim 1 , or halo; or a stereoisomer claim 1 , mixture of stereoisomers claim 1 , and/or a pharmaceutically acceptable salt thereof.6. The Compound of claim 1 , wherein two Rare each hydrogen and the third Ris alkyl claim 1 , haloalkyl claim 1 , or halo; or a stereoisomer claim 1 , mixture of stereoisomers claim 1 , and/or a pharmaceutically acceptable salt thereof.7. (canceled)8. The Compound of claim 1 , wherein two Rare each hydrogen and the third Ris halo; or a stereoisomer claim 1 , mixture of stereoisomers claim 1 , and/or a pharmaceutically acceptable salt thereof.9. The Compound of claim 1 , wherein one Ris hydrogen and the other two Rare independently halo; or a stereoisomer claim 1 , mixture of stereoisomers claim 1 , and/or a pharmaceutically acceptable salt thereof.12. The Compound of claim 11 , wherein one of X and Y is CRand the other is CH; or a stereoisomer claim 11 , mixture of stereoisomers claim 11 , and/or a pharmaceutically acceptable salt thereof.13. (canceled)14. The Compound of claim 11 , wherein one of X and Y is CRand the other is N; or a stereoisomer claim 11 , mixture of stereoisomers claim 11 , and/or a pharmaceutically acceptable salt thereof.1518-. (canceled)19. The Compound of claim 11 , wherein Ris phenyl optionally substituted with 1 claim 11 , 2 claim 11 , or 3 Rgroups; or a stereoisomer claim 11 , mixture of stereoisomers claim 11 , and/or a pharmaceutically acceptable salt thereof.20. The Compound of claim 11 , wherein Ris 5-membered heteroaryl optionally substituted with 1 claim 11 , 2 claim 11 , or 3 Rgroups; or a ...

PROPELLANE DERIVATES AND SYNTHESIS

Disclosed herein are compounds of the general Formula (I), and methods of synthesizing substituted bicyclo[1.1.1 jpentanes. The synthetic methods described herein use a [1.1.1]propellane, a Group VIII transition metal compound, a hydride source and a reagent that can contribute a substituent to form a substituted bicyclo[1.1.1]pentane, such as a compound of the general Formula (I). 1. A method for preparing a substituted bicyclo[1.1.1]pentane compound comprising:combining [1.1.1]propellane;a Group VIII transition metal compound;a hydride source; anda reagent capable of contributing all or a part of a substituent group such that bicyclo[1.1.1]pentane is substituted with the substituent group.3. The method of claim 2 , wherein Ris —N claim 2 , halogen claim 2 , —CN claim 2 , —OH claim 2 , —SCN claim 2 , —NCO claim 2 , —NO claim 2 , —C(═NOR)(CN) claim 2 , —CH(═NOR) or —COH.4. The method of claim 2 , wherein Ris an optionally substituted Calkyl claim 2 , an optionally substituted Calkenyl claim 2 , an optionally substituted Calkynyl claim 2 , an optionally substituted cycloalkyl claim 2 , an optionally substituted cycloalkenyl claim 2 , an optionally substituted cycloalkynyl claim 2 , an optionally substituted aryl claim 2 , an optionally substituted heteroaryl claim 2 , an optionally substituted heterocyclyl claim 2 , an optionally substituted aryl(Calkyl) claim 2 , an optionally substituted heteroaryl(Calkyl) claim 2 , an optionally substituted heterocyclyl(Calkyl) claim 2 , an optionally substituted alkoxy claim 2 , an optionally substituted acyl claim 2 , an optionally substituted amino claim 2 , an optionally substituted alkoxyalkyl claim 2 , an optionally substituted acylalkyl claim 2 , an optionally substituted aminoalkyl claim 2 , an optionally substituted hydroxyalkyl claim 2 , an optionally substituted haloalkyl claim 2 , an optionally substituted haloalkoxy claim 2 , an optionally substituted arylthio claim 2 , or an optionally substituted alkylthio.5. The ...

PROCESS FOR THE PREPARATION OF CYCLOHEXYL-SUBSTITUTED TERTIARY ALKANOLS

The present invention relates to processes for the preparation of compounds of the formula (Ia) 115-. (canceled)17. The process according to claim 16 , wherein Rand R claim 16 , independently of one another claim 16 , are selected from the group consisting of C-alkyl claim 16 , C-cycloalkyl and C-cycloalkylalkyl.18. The process according to claim 16 , wherein the reaction in step a) takes place under conditions under which the compound of the formula (II) is present in the supercritical state.20. The process according to claim 16 , wherein the reaction in step a) takes place at a temperature in the range from 250 to 500° C. and a pressure in the range from 5 to 50 MPa.21. The process according to claim 16 , wherein the molar ratio of the styrene used in step a) to the compound of the formula (II) used in step a) is in the range from 1:5 to 1:200.22. The process according to claim 16 , wherein the catalyst used in step b) comprises at least one active metal selected from the group consisting of palladium claim 16 , platinum claim 16 , cobalt claim 16 , nickel claim 16 , rhodium claim 16 , iridium and ruthenium.23. The process according to claim 21 , wherein the catalyst used in step b) comprises ruthenium as active metal.24. The process according to claim 21 , wherein the catalyst used in step b) comprises at least one further active metal of sub-groups IB claim 21 , VIIB or VIIIB of the Periodic Table (CAS version).25. The process according to claim 16 , wherein step b) is carried out in trickle mode.26. The process according to claim 16 , wherein Ris methyl and Ris ethyl.28. The compound according to claim 27 , wherein Rand R claim 27 , independently of one another claim 27 , are selected from the group consisting of C-alkyl claim 27 , C-cycloalkyl and C-cycloalkylalkyl.30. The compound according to claim 29 , wherein Rand R claim 29 , independently of one another claim 29 , are selected from the group consisting of C-alkyl claim 29 , C-cycloalkyl and C- ...

USE OF AROMATIC ALCOHOL AS STRUCTURAL INDUCER AND METHOD FOR TREATING SILK FIBROIN

The present invention provides use of an aromatic alcohol as a structural inducer for silk fibroin, and also provides a method for treating silk fibroin. The method includes the following steps: bringing silk fibroin into contact with an aromatic alcohol-containing vapor or liquid to induce the structural transformation of silk fibroin, to obtain a water-insoluble silk fibroin, wherein the mechanical performance of the resulting silk fibroin material and the bonding strength between the silk fibroin material and a substrate material are over 50% higher than those of a silk fibroin material obtained by a traditional treatment method (induction with methanol, ethanol, and steam). 1. Use of an aromatic alcohol as a structural inducer for silk fibroin.3. The use according to claim 1 , the aromatic alcohol is in a liquid or vapor state.4. A treatment method for obtaining a water-insoluble silk fibroin material claim 1 , comprising steps of:bringing silk fibroin into contact with an aromatic alcohol-containing vapor or liquid to induce the structural transformation of silk fibroin, to obtain the water-insoluble silk fibroin material.6. The treatment method according to claim 4 , wherein the silk fibroin material is in a dry state and has a moisture content of not higher than 30%.7. The treatment method according to claim 4 , wherein the silk fibroin material is soaked in an aromatic alcohol-containing liquid or the silk fibroin material is fumigated with an aromatic alcohol-containing vapor.8. The treatment method according to claim 4 , wherein when an aromatic alcohol-containing liquid is used for treatment claim 4 , the treatment time is not less than 5 seconds; and the treatment temperature is 20-200° C.9. The treatment method according to claim 4 , wherein when an aromatic alcohol-containing vapor is used for treatment claim 4 , the treatment time is not less than 5 min claim 4 , and the treatment temperature is 25-200° C.10. The treatment method according to claim 4 ...

NOVEL AROMA CHEMICALS HAVING A 1,2,2-TRIMETHYLCYCLOPENTAN-1-YL MOIETY

The present invention relates to novel compounds of general formulae (la), (lb) and (Ic) and to the stereoisomers thereof. The compounds are useful as a fragrance or as flavor as they have a sandalwood like scent. The invention also relates to a method for imparting or modifying a scent or a flavor to a composition by including said compounds into such composition, to a fragrance containing composition and/or a fragrance material containing said compound and to a process for preparing these compounds. X is C(R)—OH or C═O; Ris selected from the group consisting of hydrogen, C-C-alkyl, C-C-alkenyl and C-C-cycloalkyl, Ris selected from the group consisting of hydrogen, C-C-alkyl, C-C-alkenyl and C-C-cycloalkyl, Ris C-C-alkyl, Ris selected from the group consisting of hydrogen and C-C-alkyl, Ris hydrogen or together with Ris CH; Ris selected from the group consisting of hydrogen and C-C-alkyl. 114.-. (canceled)16. The compound or mixture of claim 15 , wherein X is CO.17. The compound or mixture of claim 15 , wherein X is CH—OH.18. The compound or mixture of claim 15 , which is a compound of formula (Ia) claim 15 , a mixture of compounds of formula (Ia) or a mixture of at least one compound of formula (Ia) with one or more compounds of the formulae (Ic).19. The compound or mixture of claim 15 , which is a compound of formula (Ic) claim 15 , a mixture of compounds of formula (Ic) or a mixture of at least one compound of formula (Ic) with one or more compounds of the formulae (Ia).20. The compound of claim 15 , which is selected from the group consisting of4-(1,2,2-trimethylcyclopentyl)but-2-enal,2-methyl-4-(1,2,2-trimethylcyclopentyl)but-2-enal,2-ethyl-4-(1,2,2-trimethylcyclopentyl)but-2-enal,5-(1,2,2-trimethylcyclopentyl)pent-3-en-2-one,3-methyl-5-(1,2,2-trimethylcyclopentyl)pent-3-en-2-one,3-ethyl-5-(1,2,2-trimethylcyclopentyl)pent-3-en-2-one,6-(1,2,2-trimethylcyclopentyl)hex-4-en-3-one,4-methyl-6-(1,2,2-trimethylcyclopentyl)hex-4-en-3-one,4-(1,2,2-trimethylcyclopentyl) ...

1-HYDROXYMETHYL-1,2,2,6-TETRAMETHYL-CYCLOHEXANE AND DERIVATIVES THEREOF AND THEIR USE AS AROMA CHEMICALS

The invention relates to compounds of formula (A) as defined herein, and esters of the compound of formula (A), and ketones of the compound of formula (A). The invention further relates to a method for preparing compounds of formula (A) and esters of the compound of formula (A), and ketones of the compound of formula (A). The invention further relates to the use of at least one compound selected from compounds of formula (A) and the esters of a compound of formula (A) and the ketones of a compound of formula (A) as aroma chemical. 7. The method according to claim 5 , for preparing a compound of formula (A.b) claim 5 , wherein in step iib) claim 5 , the nucleophilic agent is selected from metal C-C-alkyl compounds and metal C-C-alkenyl compounds claim 5 , which comprise at least one ligand R.10. The use of a compound according to as aroma chemical.13. The perfumed or aromatized product according to claim 12 , wherein the product is preferably selected from scent dispensers and fragrances perfumes claim 12 , detergents and cleaners claim 12 , cosmetic compositions claim 12 , body care compositions claim 12 , hygiene articles claim 12 , products for oral and dental hygiene claim 12 , scent dispensers claim 12 , fragrances claim 12 , pharmaceutical compositions and crop protection compositions. Despite a large number of existing aroma chemicals (fragrances and flavorings), there is a constant need for new components in order to be able to satisfy the multitude of properties desired for extremely diverse areas of application. These include, firstly, the organoleptic properties, i.e. the compounds should have advantageous odiferous (olfactory) or gustatory properties. Furthermore, aroma chemicals should, however, also have additional positive secondary properties, such as e.g. an efficient preparation method, the possibility of providing better sensory profiles as a result of synergistic effects with other fragrances, a higher stability under certain application ...

Ladderane Lipid Compounds and Liposomes and Methods of Preparing and Using the Same

Methods for preparing a variety of ladderane precursors, ladderane compounds and ladderane lipids are provided. Also provided are methods of preparing a liposome from the ladderane lipids disclosed herein, and compositions thereof. Aspects of the invention include encapsulated one or more cargo moieties in the liposome or compositions thereof and use of the subject liposome compositions as vehicles in drug delivery, imaging, diagnostics and other medical applications. Aspects of the methods disclosed herein include administering a liposomal composition comprising a pharmaceutical agent to a subject under conditions sufficient to deliver the composition to a site of interest in the subject, and release the pharmaceutical agent from the liposomal composition. 7. The method according to claim 6 , wherein the hydrophilic head group is selected from the group consisting of phosphocholine claim 6 , phosphoethanolamine claim 6 , phosphoserine claim 6 , phosphoinositol claim 6 , ethylphosphosphorylcholine claim 6 , polyethyleneglycol claim 6 , melamine claim 6 , glucosamine claim 6 , trimethylamine.11. The method according to claim 2 , wherein the compound of formula (IV) is prepared by enantioselective hydroboration claim 2 , in 80% or more e.e.15. The ladderane precursor according to claim 14 , wherein Lis an aliphatic hydrocarbon that is saturated or unsaturated claim 14 , linear or branched claim 14 , substituted or unsubstituted.16. The ladderane precursor according to claim 14 , wherein Zis selected from the group consisting of claim 14 , carboxylic acid claim 14 , alcohol claim 14 , ester claim 14 , ether claim 14 , amine claim 14 , amide claim 14 , thiol.19. The composition according to claim 18 , wherein the one or more cargo moieties are selected from the group consisting of an enzyme claim 18 , a pharmaceutical agent claim 18 , a plasmid claim 18 , a polynucleotide claim 18 , a polypeptide claim 18 , a sensor claim 18 , a metal claim 18 , a polymer claim 18 , a ...

PROCESS FOR PREPARING 4-CYCLOHEXYL-2-METHYL-2-BUTANOL

The present invention relates to a process for preparing 4-cyclohexyl-2-methyl-2-butanol. The process comprises the following steps: 135-. (canceled)36. 4-Cyclohexyl-2-methyl-2-pentanol.37. A process for preparing 4-cyclohexyl-2-methyl-2-pentanol , comprising the heterogeneously catalyzed hydrogenation of 2-methyl-4-phenyl-2-pentanol over a catalyst suitable for ring hydrogenation of aromatics.38. The process according to claim 37 , comprisinga′) preparing a composition comprising 2-methyl-4-phenyl-2-butanol and 2-methyl-4-phenyl-2-pentanol by reaction of styrene with isopropanol at elevated temperature under conditions under which isopropanol is present under supercritical conditions, the molar ratio of styrene to isopropanol being in the range from 1:10 to 1:130;b′) heterogeneously catalyzed hydrogenation of the composition obtained in step a′) over a catalyst suitable for ring hydrogenation of aromatics; andc) distillative workup of the composition obtained in step b′) to obtain a composition consisting essentially of 4-cyclohexyl-2-methyl-2-pentanol;orc′) distillative workup of the composition obtained in step a′) to obtain a composition consisting predominantly of 2-methyl-4-phenyl-2-pentanol andb′) heterogeneously catalyzed hydrogenation of the composition obtained in step c) over a catalyst suitable for ring hydrogenation of aromatics; and optionallyc″) distillative workup of the composition obtained in step b′) to obtain a composition consisting essentially of 4-cyclohexyl-2-methyl-2-pentanol.39. The process according to claim 37 , comprising:a″) reacting α-methylstyrene with isopropanol at elevated temperature to obtain 2-methyl-4-phenyl-2-pentanol, andb″) heterogeneously catalyzed hydrogenation of 2-methyl-4-phenyl-2-pentanol over a catalyst suitable for ring hydrogenation of aromatics.40. A composition comprising 4-cyclohexyl-2-methyl-2-pentanol.41. The composition as claimed in claim 40 , which additionally comprises 4-cyclohexyl-2-methyl-2-butanol.42. ...

PROCESSES FOR MAKING CYCLOHEXANE COMPOUNDS

This invention relates to hydrogenation processes for making cyclohexane compounds. More specifically, this invention relates to hydrogenation processes in the presence of tertiary amide solvent compounds, as well as compositions that can result from such processes. The invention thus provides processes for making cyclohexanecarboxylic acid compounds and processes for making hydroxymethylcyclohexane compounds. 1. A composition comprising a hydroxymethylcyclohexane compound dissolved in a solvent, wherein the solvent comprises at least about 50% by weight of a tertiary cyclic amide solvent compound. This application is a divisional of U.S. patent application Ser. No. 14/143,914, filed on Dec. 30, 2013, the disclosure of which is incorporated herein by reference in its entirety.This invention relates to hydrogenation processes for making cyclohexane compounds. More specifically, this invention relates to hydrogenation processes in the presence of tertiary amide solvent compounds, as well as compositions that can result from such processes.Cyclohexanecarboxylic acid compounds and hydroxymethylcyclohexane compounds are important commercial chemicals. For example, diacids such as 1,4-cyclohexanedicarboxylic acid (CHDA) and 1,3-cyclohexanedicarboxylic acid and diols such as 1,4-cyclohexanedimethanol (CHDM) are useful monomers in formation of a wide variety of polymers and intermediates in a variety of additional reactions. 1,4-CHDA production can act as an intermediate for the synthesis of 1,4-cyclohexanedimethanol (CHDM). The monoacid cyclohexanecarboxylic acid is used as a raw material in synthesis of other compounds, and cyclohexanecarboxylic acid and several of its derivatives are useful as flavor and fragrance agents. Many cyclohexanecarboxylic acid compounds are prepared by hydrogenation of benzenecarboxylic acids. For example, there exists processes for synthesis of 1,4-CHDA from terephthalic acid (TPA). Many such processes suffer the drawback that they use ...

MALODOR COUNTERACTING COMPOSITIONS

The use of alcohols of formula (I)× 3. The method of wherein the compound of formula (I) or a mixture thereof is released in such a concentration that the ratio between the compound of formula (I) and the malodour is from about 1:1 to about 1:100 in the atmosphere.4. The method according to wherein the compound of formula (I) is selected from cycloundecanol claim 2 , cyclododecanol claim 2 , cyclotridecanol claim 2 , 1-methylcyclotridecanol claim 2 , cyclopentadecanol claim 2 , 4-(tert-pentyl)cyclohexanol claim 2 , 4-cyclohexylcyclohexanol claim 2 , 2-cyclohexylcyclohexanol claim 2 , 3-(4-isobutylcyclohexyl)-2-methylpropan-1-ol claim 2 , 3-(3-tert-butylcyclohexyl)-2-methyl propan-1-ol claim 2 , 3-(3-isopropylcyclohexyl)-2-methylbutan-1-ol claim 2 , 3-(4-isopropylcyclohexyl)-2-methylpropan-1-ol claim 2 , and 3-(3-isopropylcyclohexyl)-butan-1-ol.5. (canceled)7. The method of wherein the compound of formula (I) or a mixture thereof is released in such a concentration that the ratio between the compound of formula (I) and the malodour is from about 1:1 to about 1:100 in the atmosphere.8. The method according to wherein the compound of formula (I) is selected from cycloundecanol claim 7 , cyclododecanol claim 7 , cyclotridecanol claim 7 , 1-methylcyclotridecanol claim 7 , cyclopentadecanol claim 7 , 4-(tert-pentyl)cyclohexanol claim 7 , 4-cyclohexylcyclohexanol claim 7 , 2-cyclohexylcyclohexanol claim 7 , 3-(4-isobutylcyclohexyl)-2-methylpropan-1-ol claim 7 , 3-(3-tert-butylcyclohexyl)-2-methylpropan-1-ol claim 7 , 3-(3-isopropylcyclohexyl)-2-methylbutan-1-ol claim 7 , 3-(4-isopropylcyclohexyl)-2-methylpropan-1-ol claim 7 , and 3-(3-isopropylcyclohexyl)-butan-1-ol.9. The method according to wherein the compound of formula (I) is selected from cycloundecanol claim 1 , cyclododecanol claim 1 , cyclotridecanol claim 1 , 1-methylcyclotridecanol claim 1 , cyclopentadecanol claim 1 , 4-(tert-pentyl)cyclohexanol claim 1 , 4-cyclohexylcyclohexanol claim 1 , 2- ...

PERFUME SYSTEMS

The present application relates to perfume raw materials, perfume delivery systems and consumer products comprising such perfume raw materials and/or such perfume delivery systems, as well as processes for making and using such perfume raw materials, perfume delivery systems and consumer products. Such perfume raw materials and compositions, including the delivery systems, disclosed herein expand the perfume communities' options as such perfume raw materials can provide variations on character and such compositions can provide desired odor profiles. 2. A perfume according to comprising claim 1 , based on total perfume weight claim 1 , from about 0.0001% to about 50% of said perfume raw material.3. A consumer product comprising the perfume according to and an adjunct ingredient.4. A consumer product comprising the perfume according to claim 2 , said consumer product being a cleaning and/or treatment composition and comprising an adjunct ingredient.5. A consumer product according to claim 4 , said consumer product being a fabric and/or hard surface cleaning and/or treatment composition claim 4 , said composition comprising claim 4 , based on total composition weight claim 4 , from about 0.00001% to about 35% of said perfume.6. A consumer product according to claim 4 , said consumer product being a detergent claim 4 , said detergent comprising claim 4 , based on total detergent weight claim 4 , from about 0.00001% to about 35% of said perfume.7. A consumer product according to claim 4 , said consumer product being a highly compacted consumer product claim 4 , said highly compacted consumer product comprising claim 4 , based on total highly compacted consumer product weight claim 4 , from about 0.00001% to about 35% of said perfume.8. A perfume delivery system comprising claim 1 , based on total delivery system weight claim 1 , from about 0.001% to about 99% of the perfume of claim 1 , said perfume delivery system being a polymer assisted delivery system; a molecule- ...

NOVEL OCTAHYDROINDENYL PROPANAL COMPOUNDS

The present invention pertains to novel octahydro-indene compounds and their unexpected advantageous use thereof in enhancing, improving or modifying the fragrance of perfumes, colognes, toilet waters, fabric care products, personal products, and the like. 1. A compound selected from the group consisting of:1-(1,1-dimethyl-octahydro-inden-5-yl)-ethanol;1-(3,3-dimethyl-octahydro-inden-5-yl)-ethanol;1-(1,1-dimethyl-octahydro-inden-5-yl)-ethanone;1-(3,3-dimethyl-octahydro-inden-5-yl)-ethanone;1,1-dimethyl-octahydro-inden-5-ol;3,3-dimethyl-octahydro-inden-5-ol;1,1-dimethyl-octahydro-inden-5-one;3,3-dimethyl-octahydro-inden-5-one;1-(1,1,6-trimethyl-octahydro-inden-5-yl)-ethanol;1-(3,3,6-trimethyl-octahydro-inden-5-yl)-ethanol; anda mixture thereof.2. A fragrance formulation containing an olfactory acceptable amount of a compound selected from the group consisting of:1-(1,1-dimethyl-octahydro-inden-5-yl)-ethanol;1-(3,3-dimethyl-octahydro-inden-5-yl)-ethanol;1-(1,1-dimethyl-octahydro-inden-5-yl)-ethanone;1-(3,3-dimethyl-octahydro-inden-5-yl)-ethanone;1,1-dimethyl-octahydro-inden-5-ol;3,3-dimethyl-octahydro-inden-5-ol;1,1-dimethyl-octahydro-inden-5-one;3,3-dimethyl-octahydro-inden-5-one;1-(1,1,6-trimethyl-octahydro-inden-5-yl)-ethanol;1-(3,3,6-trimethyl-octahydro-inden-5-yl)-ethanol; anda mixture thereof.3. The fragrance formulation of claim 2 , wherein the olfactory acceptable amount is from about 0.005 to about 50 weight percent of the fragrance formulation.4. The fragrance formulation of claim 2 , wherein the olfactory acceptable amount is from about 0.5 to about 25 weight percent of the fragrance formulation.5. The fragrance formulation of claim 2 , wherein the olfactory acceptable amount is from about 1 to about 10 weight percent of the fragrance formulation.6. The fragrance formulation of further comprising a material selected from the group consisting of a polymer claim 2 , an oligomer and a non-polymer.7. The fragrance formulation of claim 6 , wherein the non- ...

COMPOUND HAVING CYCLOPROPANE RING, AND FLAVOR AND/OR FRAGRANCE COMPOSITION CONTAINING SAME

Provided are a compound of formula (1), having a cyclopropane ring, which can impart a floral or citrus-like aroma and a flavor composition containing at least one compound of formula (1): 2. The compound according to claim 1 , wherein{'sup': '4', 'Ris a group selected from a hydroxymethyl group, a 1-hydroxy-1-ethyl group, a 1-hydroxy-1-propyl group, a 1-hydroxy-1-butyl group, and a 2-hydroxy-1-propyl group.'}3. The compound according to claim 2 , wherein{'sup': 1', '3, 'Rand Rare both methyl groups.'}4. The compound according to claim 2 , wherein{'sup': 1', '2', '3, 'R, R, and Rare all methyl groups.'}5. The compound according to claim 2 , wherein{'sup': '5', 'Ris a methyl group.'}6. A flavor and/or fragrance composition claim 1 , comprising the compound according to .7. A food or beverage claim 6 , a cosmetic claim 6 , an air-freshener claim 6 , a daily necessity or grocery claim 6 , an oral cavity composition claim 6 , a hair-care product claim 6 , a skin-care product claim 6 , a body-cleaning agent claim 6 , a laundry detergent claim 6 , a laundry softener claim 6 , a toiletry product claim 6 , a fiber or fiber product claim 6 , a garment claim 6 , or a pharmaceutical claim 6 , comprising the flavor and/or fragrance composition according to . The present invention relates to a flavor and/or fragrance composition containing a compound having a cyclopropane ring.Some compounds having a cyclopropane ring are known to be useful as raw materials for flavor compositions and/or fragrance compositions. For example, [1-methyl-2-(5-methyl-4-hexen-2-yl)cyclopropyl]methanol has an odor similar to those of citrus and 3-methyl-5-phenyl-1-pentanol, with rosy floral note (WO 2012/160189 A1). Meanwhile, 1-methyl-2-[(2,2,3-trimethylcyclopentyl)methyl]cyclopropyl]methanol has a natural sandalwood-like odor (US 2010/0069508 A1). In addition, 2-(1-phenylethyl)cyclopropylmethanol and the like are known as compounds having a cyclopropane ring and a benzene ring, but their odors are ...

Polymerizable higher diamondoid derivatives

Higher diamondoid derivatives capable of taking part in polymerization reactions are disclosed as are intermediates to these derivatives, polymers formed from these derivatives and methods for preparing the polymers.

脂环式醇的制造方法

本发明的目的在于廉价且高收率地制造作为调合香料原料等有用的通式(III)所示的脂环式醇，在HF的存在下利用一氧化碳将通式(I)所示的不饱和烃(优选通过二烯化合物的部分还原而得到的物质)羰基化得到通式(II)所示的环己烷羰基化合物，然后还原该环己烷羰基化合物从而得到通式(III)所示的脂环式醇。(式中，R 1 表示碳原子数1～4的烷基。R 2 表示碳原子数1～4的烷基。R 3 表示OH基、氟、OR 4 基的任一种。R 4 表示碳原子数1～4的烷基。)

PKC-ACTIVATING COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES

The present invention relates to methods of activate an isoform of protein kinase C (PKC) for the treatment of neurological diseases including Alzheimer's disease and stroke using cyclopropanated or epoxidized derivatives of mono- and polyunsaturated fatty acids. The present invention also relates to methods of reducing neurodegeneration using cyclopropanated or epoxidized derivatives of mono- and polyunsaturated fatty acids. 151.-. (canceled)52. A method of treating multiple sclerosis , comprising administering to a patient in need thereof an effective amount of an epoxidized polyunsaturated fatty acid (PUFA) ester wherein at least one carbon-carbon unsaturated bond in said PUFA is epoxidized.53. The method of claim 52 , wherein the ester is a methyl ester.54. The method of claim 52 , wherein all carbon-carbon unsaturated bonds in said PUFA are epoxidized.55. The method of claim 52 , wherein said PUFA is selected from the group consisting of linoleic acid claim 52 , γ-linolenic acid claim 52 , α-linolenic acid claim 52 , arachidonic acid claim 52 , eicosapentaenoic acid claim 52 , eicosatetraenoic acid claim 52 , docosapentaenoic acid claim 52 , docosahexaenoic acid claim 52 , stearidonic acid claim 52 , and adrenic acid.57. The method of claim 56 , wherein R is methyl.58. The method of claim 52 , wherein the epoxidized polyunsaturated fatty acid (PUFA) ester has any of the following formulas: CH(CH)(CH=CHCH)(CH)COOR or CHCH(CH=CHCH)x(CH)COOR claim 52 , wherein x is 2-6 claim 52 , y is 2-6 claim 52 , and R is alkyl claim 52 , wherein at least one carbon-carbon unsaturated bond in said epoxidized PUFA is epoxidized. This is a continuation application of U.S. application Ser. No. 16/903,551 filed Jun. 17, 2020, which is a continuation application of U.S. application Ser. No. 16/400,132, filed May 1, 2019, now U.S. Pat. No. 10,696,644, which is a continuation application of U.S. application Ser. No. 14/803,762, filed Jul. 20, 2015, now U.S. Pat. No. 10,323,011, which ...

Glycidyl ethers of limonene derivatives and oligomers thereof as curable epoxy resins

Cured epoxy resins are widespread because of their excellent mechanical and chemical properties. Typically, epoxy resins based on bisphenol A diglycidyl ethers or bisphenol F diglycidyl ethers are used, but these are problematic for many sectors because of their effect on the endocrine system. The present invention relates to glycidyl ethers of limonene-based diols and/or polyols, and to curable epoxy resin compositions based thereon as alternatives to the bisphenol A diglycidyl ethers or bisphenol F diglycidyl ethers, or the epoxy resin compositions based thereon.

Polymerizable higher diamondoid derivatives

Higher diamondoid derivatives capable of taking part in polymerization reactions are disclosed as well as intermediates to these derivatives, polymers formed from these derivatives and methods for preparing the polymers.

process for preparing, composition, use.

processo para preparar, composição, uso. a presente invenção refere-se a um processo para a preparação 4-cicloexil-2-metil-2-butanol. o processo compreende os seguintes estágios: a) reação de estireno com isopropanol em uma temperatura elevada, dando-4-fenil-2-metil-2-butanol, e b) hidrogenação catalítica heterogênea de 4-fenil-2-metil-2-butanol por meio de um catalisador adequado para a hidrogenação de nel de aromáticos. process for preparing, composition, use. The present invention relates to a process for preparing 4-cyclohexyl-2-methyl-2-butanol. the process comprises the following stages: a) reacting styrene with isopropanol at an elevated temperature giving 4-phenyl-2-methyl-2-butanol, and b) heterogeneous catalytic hydrogenation of 4-phenyl-2-methyl-2-butanol by means of a suitable catalyst for the hydrogenation of aromatics.

Novel alicyclic-type diol compound, and method for producing same

본 발명의 지환식 디올 화합물은, 하기 식(1)로 표시된다. The alicyclic diol compound of this invention is represented by following formula (1).

Method for the effective preparation of 1-cyclohexyl-1-ethanol

본 발명은 고효율의 1-시클로헥실-1-에탄올의 제조방법에 관한 것으로, 좀 더 상세하게는 산 세기 지수 10%이하인 실리카 지지체에 1∼5무게%의 루테늄을 분산 담지하여 제조한 촉매를 사용하고, 반응 생성물인 1-시클로헥실-1-에탄올의 일부를 희석제로 사용하여 반응 원료인 1-메틸벤질알콜 및/또는 아세토페논과 혼합, 희석한 후 연속적으로 수소화시킴으로서 고수율 및 고효율로 1-시클로헥실-1-에탄올을 제조하는 방법에 관한 것이다. The present invention relates to a method for preparing high-efficiency 1-cyclohexyl-1-ethanol, and more particularly, using a catalyst prepared by dispersing and carrying 1 to 5 weight% of ruthenium on a silica support having an acid strength index of 10% or less. A portion of 1-cyclohexyl-1-ethanol, a reaction product, is mixed with diluent 1-methylbenzyl alcohol and / or acetophenone as a diluent, diluted, and then continuously hydrogenated to yield high yield and high efficiency. A method for producing cyclohexyl-1-ethanol. 1-메틸벤질알콜, 아세토페논, 1-시클로헥실-1-에탄올, 산 세기 지수, 실리카 1-methylbenzyl alcohol, acetophenone, 1-cyclohexyl-1-ethanol, acid strength index, silica

Method of obtaining alicyclic alcohol

FIELD: chemistry. SUBSTANCE: invention relates to an improved method of obtaining alicyclic alcohol of structural formula (III) The method includes obtaining a cyclohexanecarbonyl compound, represented by general formula (II) carbonylation of unsaturated hydrocarbon, represented by general formula (I) with the application of carbon monoxide in the presence of HF with further obtaining alicyclic alcohol, represented by general formula (III), and reduction of the said cyclohexanecarbonyl compound, represented by general formula (II). In structural formulas (I)-(III) R 1 represents an alkyl group, containing 1-4 carbon atoms, R 2 represents an alkyl group, containing 1-4 carbon atoms, R 3 represents an OH group, fluorine or an OR 4 group, and R 4 represents an alkyl group, containing 1-4 carbon atoms. EFFECT: method makes it possible to obtain the product with low expenditures, high output and high purity of the cis-form. 11 cl, 2 ex РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 2 530 880 C2 (51) МПК C07C 29/147 (2006.01) C07C 31/135 (2006.01) C07C 67/38 (2006.01) C07C 69/75 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ОПИСАНИЕ (21)(22) Заявка: ИЗОБРЕТЕНИЯ К ПАТЕНТУ 2012103332/04, 30.06.2010 (24) Дата начала отсчета срока действия патента: 30.06.2010 Приоритет(ы): (30) Конвенционный приоритет: (43) Дата публикации заявки: 10.08.2013 Бюл. № 22 (73) Патентообладатель(и): МИЦУБИСИ ГЭС КЕМИКАЛ КОМПАНИ, ИНК. (JP) R U 01.07.2009 JP 2009-157125 (72) Автор(ы): КИТАМУРА Мицухару (JP), КОТАТИ Синдзи (JP), НАГАСАВА Синия (JP), АТАКА Йосихару (JP) (45) Опубликовано: 20.10.2014 Бюл. № 29 C 2 C 2 A, 31.10.1995. GB1545562 A, 10.05.1979. WO1994013766 A2, 23.06.1994. SU1397424 A1, 23.05.1988. G.W. BUCHANAN ET AL., “13C nuclear magnetic resonance studies. XII. Conformational effects on 13C shieldings in alicyclic oxygenated compounds”, Canadian Journal of Chemistry, 1969, 47(17), pp. 31133118 (85) Дата начала рассмотрения заявки PCT на национальной фазе: 01.02.2012 2 5 3 ...

新型脂环族醇

本发明目的在于提供可用作调合香料原料的、具有爽朗且带清新感的优异花卉-植物般香气的脂环族醇化合物、其制造方法和含有该脂环族醇化合物的香料组合物，发现化学式（1）所示的特定结构的脂环族醇化合物具有爽朗且带清新感的优异花卉-植物般香气，并找到用来制造化学式（1）所示的脂环族醇化合物的方法，该方法为：在氟化氢的存在下，使4-异丙基-1-甲基环己烯与一氧化碳反应，将所得4-异丙基-1-甲基环己烷酰氟异构化，形成2-甲基-2-(4-甲基环己基)丙酰氟，使之与醇反应，获得环己烷羰基化合物，然后将环己烷羰基化合物还原。

Novel alicyclic alcohol

FIELD: chemistry. SUBSTANCE: present invention relates to a novel alicyclic alcohol compound of chemical formula which can be used as raw material for a perfume composition and which has an excellent flowery-herblike aroma with refreshing notes. The invention also relates to a perfume composition containing the disclosed alicyclic alcohol compound and to a method for production thereof. The production method includes reacting 4-isopropyl-1-methylcyclohexene with carbon monoxide in the presence of hydrogen fluoride, isomerising the obtained 4-isopropyl-1-methylcyclohexanecarboxylic acid fluoride to obtain 2-methyl-2-(4-methylcyclohexyl)propionyl fluoride, followed by reaction thereof with an alcohol to obtain a carbonyl compound of cyclohexane, and then reducing the carbonyl compound of hexane. EFFECT: obtaining a novel alicyclic alcohol compound. 3 cl, 4 ex РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 2 564 416 C2 (51) МПК C07C 31/135 (2006.01) C07C 29/149 (2006.01) C11B 9/00 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ОПИСАНИЕ (21)(22) Заявка: ИЗОБРЕТЕНИЯ К ПАТЕНТУ 2013135298/04, 27.12.2011 (24) Дата начала отсчета срока действия патента: 27.12.2011 Приоритет(ы): (30) Конвенционный приоритет: (72) Автор(ы): КИТАМУРА Мицухару (JP), АТАКА Йосихару (JP), ФУКУДА Казуюки (JP) 28.12.2010 JP 2010-292939 (43) Дата публикации заявки: 10.02.2015 Бюл. № 4 R U (73) Патентообладатель(и): МИЦУБИСИ ГЭС КЕМИКАЛ КОМПАНИ, ИНК. (JP) (45) Опубликовано: 27.09.2015 Бюл. № 27 2 5 6 4 4 1 6 (56) Список документов, цитированных в отчете о поиске: US 5104851A1, 14.04.1992 . JP 2001199806A, 24.07.2001 . US 6489273B1, 03.12.2002 . US 20090163733A1, 25.06.2009 . SU 154266A1, 24.07.1963 (85) Дата начала рассмотрения заявки PCT на национальной фазе: 29.07.2013 (86) Заявка PCT: 2 5 6 4 4 1 6 R U C 2 C 2 JP 2011/080149 (27.12.2011) (87) Публикация заявки PCT: WO 2012/090977 (05.07.2012) Адрес для переписки: 129090, Москва, ул. Б. Спасская, 25, строение 3, ООО "Юридическая фирма ...

Propellane derivates and synthesis

Perfume systems

The present application relates to perfume raw materials, perfume delivery systems and consumer products comprising such perfume raw materials and/or such perfume delivery systems, as well as processes for making and using such perfume raw materials, perfume delivery systems and consumer products. Such perfume raw materials and compositions, including the delivery systems, disclosed herein expand the perfume communities' options as such perfume raw materials can provide variations on character and such compositions can provide desired odor profiles.

Perfume systems

The present application relates to perfume delivery systems and consumer products comprising perfume raw materials and/or perfume delivery systems, as well as processes for making and using such perfume raw materials, perfume delivery systems and consumer products. Such perfume raw materials and compositions, including the delivery systems, disclosed herein expand the perfume communities' options as such perfume raw materials can provide variations on character and such compositions can provide desired odor profiles.The prefume raw material is selected from (1R,5S)-6,6-dimethylbicyclo[3.1.1]hept-2-en derivatives.

Perfume systems

The present application relates to perfume raw materials, perfume delivery systems and consumer products comprising such perfume raw materials and/or such perfume delivery systems, as well as processes for making and using such perfume raw materials, perfume delivery systems and consumer products, wherein the perfume raw material is 3-((1R, 5S)-6,6-dimethylbicyclo[3.1.1]hept-2-en-2yl)-2,2-dimethylpropanal. Such perfume raw materials and compositions, including the delivery systems, disclosed herein expand the perfume communities' options as such perfume raw materials can provide variations on character and such compositions can provide desired odor profiles.

Perfume systems

The present application relates to perfume raw materials, perfume delivery systems and consumer products comprising such perfume raw materials and/or such perfume delivery systems, as well as processes for making and using such perfume raw materials, perfume delivery systems and consumer products. Such perfume raw materials and compositions, including the delivery systems, disclosed herein expand the perfume communities' options as such perfume raw materials can provide variations on character and such compositions can provide desired odor profiles.

Perfume

METHOD FOR GETTING A ALICYCLIC ALCOHOL

1. Способ получения алициклического спирта, включающийполучение циклогексанкарбонильного соединения, представленного общей формулой (II), карбонилированием ненасыщенного углеводорода, представленного общей формулой (I), с использованием монооксида углерода в присутствии HF, и затем получение алициклического спирта, представленного общей формулой (III), восстановлением указанного циклогексанкарбонильного соединения, представленного общей формулой (II),химическая формула 1где Rпредставляет алкильную группу, содержащую 1-4 атома углерода, Rпредставляет алкильную группу, содержащую 1-4 атома углерода, Rпредставляет ОН группу, фтор или ORгруппу, и Rпредставляет алкильную группу, содержащую 1-4 атома углерода.2. Способ по п.1, в котором указанное карбонилирование осуществляют при давлении монооксида углерода, равном 5 МПа или ниже.3. Способ по п.1 или 2, в котором указанное карбонилирование осуществляют при температуре от -50°С до -25°С.4. Способ по п.1, в котором Rв указанной общей формуле (II) представляет собой ORгруппу, в которой Rпредставляет алкильную группу, содержащую 1-4 атома углерода.5. Способ по п.1, в котором чистота цисформы указанного циклогексанкарбонильного соединения, представленного общей формулой (II), полученного карбонилированием, составляет 85% или более.6. Способ по п.1, в котором указанное циклогексанкарбонильное соединение, представленное общей формулой (II), восстанавливают, используя водород.7. Способ по п.1, в котором указанное циклогексанкарбонильное соединение, представленное общей формулой (II), восстанавливают, используя водород и катализатор, включающий, по меньшей мере, один металл, выбранный из металлов 8-11 � РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (51) МПК C07C 29/147 (13) 2012 103 332 A (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ЗАЯВКА НА ИЗОБРЕТЕНИЕ (21)(22) Заявка: 2012103332/04, 30.06.2010 (71) Заявитель(и): МИЦУБИСИ ГЭС КЕМИКАЛ КОМПАНИ, ИНК. (JP) Приоритет(ы): (30) Конвенционный приоритет: 01.07.2009 JP 2009- ...

NEW ALYCYCLIC ALCOHOL

1. Алициклическое спиртовое соединение, представленное химической формулой (1)2. Парфюмерная композиция, содержащая алициклическое спиртовое соединение, представленное химической формулой (1)3. Способ получения алициклического спиртового соединения, представленного химической формулой (1), путемвзаимодействия 4-изопропил-1-метилциклогексена, представленного химической формулой (2), с монооксидом углерода в присутствии фторида водорода,изомеризации получаемого фторангидрида 4-изопропил-1-метилциклогексанкарбоновой кислоты, представленного химической формулой (3), с получением 2-метил-2-(4-метилциклогексил)пропионилфторида, представленного химической формулой (4),взаимодействия указанного 2-метил-2-(4-метилциклогексил)пропионилфторида со спиртом с получением карбонильного соединения циклогексана, представленного общей формулой (5), ивосстановления карбонильного соединения циклогексана, представленного общей формулой (5), с получением указанного алициклического спиртового соединения, представленного химической формулой (1),где R представляет собой алкильную группу, содержащую 1-4 углеродных атома. РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (51) МПК C07C 31/135 (13) 2013 135 298 A (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ЗАЯВКА НА ИЗОБРЕТЕНИЕ (21)(22) Заявка: 2013135298/04, 27.12.2011 (71) Заявитель(и): МИЦУБИСИ ГЭС КЕМИКАЛ КОМПАНИ, ИНК. (JP) Приоритет(ы): (30) Конвенционный приоритет: 28.12.2010 JP 2010-292939 (85) Дата начала рассмотрения заявки PCT на национальной фазе: 29.07.2013 R U (43) Дата публикации заявки: 10.02.2015 Бюл. № 4 (72) Автор(ы): КИТАМУРА Мицухару (JP), АТАКА Йосихару (JP), ФУКУДА Казуюки (JP) (86) Заявка PCT: (87) Публикация заявки PCT: WO 2012/090977 (05.07.2012) A Адрес для переписки: 129090, Москва, ул. Б. Спасская, 25, строение 3, ООО "Юридическая фирма Городисский и Партнеры" (57) Формула изобретения 1. Алициклическое спиртовое соединение, представленное химической формулой (1) A 2. Парфюмерная композиция, содержащая ...

Bicyclic aliphatic alcohol, method for producing the same, method for imparting, modifying or improving the smell of fragrance, fragrance substrate and fragrance product, and fragrance, fragrance substrate and fragrance product

NEW ALYCYCLIC ALCOHOL

1. Алициклическое спиртовое соединение, представленное химической формулой (1)2. Парфюмерная композиция, содержащая алициклическое спиртовое соединение, представленное химической формулой (1)3. Способ получения алициклического спиртового соединения, представленного химической формулой (1), путемвзаимодействия 1-изопропил-4-метилциклогексена, представленного химической формулой (2), с монооксидом углерода в присутствии фторида водорода,взаимодействия полученного фторангидрида 4-изопропил-1-метилциклогексанкарбоновой кислоты, представленного химической формулой (3), со спиртом с получением карбонильного соединения циклогексана, представленного общей формулой (4), ивосстановления указанного карбонильного соединения циклогексана, представленного общей формулой (4), с получением указанного алициклического спиртового соединения, представленного химической формулой (1),где R представляет собой алкильную группу, содержащую 1-4 углеродных атома. РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (51) МПК C07C 33/14 (13) 2013 135 299 A (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ЗАЯВКА НА ИЗОБРЕТЕНИЕ (21)(22) Заявка: 2013135299/04, 27.12.2011 (71) Заявитель(и): МИЦУБИСИ ГЭС КЕМИКАЛ КОМПАНИ, ИНК. (JP) Приоритет(ы): (30) Конвенционный приоритет: 28.12.2010 JP 2010-292938 (85) Дата начала рассмотрения заявки PCT на национальной фазе: 29.07.2013 R U (43) Дата публикации заявки: 10.02.2015 Бюл. № 4 (72) Автор(ы): КИТАМУРА Мицухару (JP), АТАКА Йосихару (JP), ФУКУДА Казуюки (JP) (86) Заявка PCT: (87) Публикация заявки PCT: WO 2012/090976 (05.07.2012) A Адрес для переписки: 129090, Москва, ул. Б. Спасская, 25, строение 3, ООО "Юридическая фирма Городисский и Партнеры" (57) Формула изобретения 1. Алициклическое спиртовое соединение, представленное химической формулой (1) A 2. Парфюмерная композиция, содержащая алициклическое спиртовое соединение, представленное химической формулой (1) R U 2 0 1 3 1 3 5 2 9 9 (54) НОВЫЙ АЛИЦИКЛИЧЕСКИЙ СПИРТ 2 0 1 3 1 3 5 2 9 9 JP 2011/080148 (27 ...

Method of obtaining thiazole derivatives or salts thereof

New incense-imparting agent

(57)【要約】 【課題】 長く持続する強いびゃくだん調のにおいを有 し、多数の天然および合成未加工香料材料と調和する新 規着香物質を提供する。 【解決手段】 【化１】 式中、Ｒ 1 からＲ 7 は独立してＨ、メチルあるいはエチ ルであり、Ｒ 8 ＋Ｒ 9 はメチレン（−ＣＨ 2 −）あるい は単結合を表わし、またはＲ 1 ＋Ｒ 2 は−（ＣＨ 2 ） n −（ｎは３あるいは４である）も形成することができ、 Ｒ 3 ＋Ｒ 5 あるいはＲ 5 ＋Ｒ 7 はメチレン、単結合ある いは２個の水素も表わすことができ、分子中に必ず少な くとも１個のシクロプロパン環が存在しなければなら ず、そして側鎖は飽和であることができ、またはα，β 位かβ，γ位に一つの二重結合を含むことができる、を 有する化合物。

Non-peptidic inhibitors of akap/pka interaction

Die Erfindung betrifft nicht-peptidische Moleküle, die die Interaktion von Proteinkinase A (PKA) und Proteinkinase A-Ankerproteinen (AKAP) modulieren, insbesondere inhibieren und einen Wirts- oder Zielorganismus, der diese nicht-peptidischen Verbindungen oder Erkennungsmoleküle, die gegen diese gerichtet sind, wie z. B. Antikörper oder Chelatoren, umfasst; die Erfindung betrifft weiterhin ein pharmazeutisches Mittel, insbesondere für die Behandlung von Krankheiten, die mit einer Störung des cAMP-Signalweges assoziiert sind, insbesondere Diabetes insipidus, Hypertonie, Diabetes mellitus, Ulcus duodeni, Asthma, Herzinsuffizienz, Adipositas, AIDS, Ödeme, Leberzirrhose, Schizophrenie und andere. Die Erfindung betrifft auch die Verwendung der erfindungsgemäßen Moleküle.

Alphaahalomethylamines

New alicycle diol compound and method of its obtainment

FIELD: chemistry. SUBSTANCE: present invention relates to the method for preparing the alicyclic diol compound of the formula (1), which can be used as a raw material for polyester resins. Method comprises introducing 4-isopropenyl-1-methyl-1-cyclohexene of formula (4) into reaction with carbon monoxide in the presence of hydrogen fluoride in order to obtain the alicyclic dicarboxylic acid fluoride of the formula (3), introducing the resulting compound of formula (3) into the reaction with alcohol in order to prepare the ester compound of the alicyclic dicarboxylic acid of formula (2) and to reduce the resulting compound of the formula (2) in order to obtain the alicyclic diol compound of formula (1): where R is an alkyl functional group containing 1 to 4 carbon atoms. EFFECT: proposed method is environmentally friendly with respect to carbon neutrality. 1 cl, 6 dwg, 1 ex РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 2 646 220 C2 (51) МПК C07C 29/147 (2006.01) C07C 31/135 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ОПИСАНИЕ ИЗОБРЕТЕНИЯ К ПАТЕНТУ (52) СПК C07C 29/147 (2006.01) (21)(22) Заявка: 2015118163, 11.10.2013 (24) Дата начала отсчета срока действия патента: (73) Патентообладатель(и): МИЦУБИСИ ГЭС КЕМИКАЛ КОМПАНИ, ИНК. (JP) Дата регистрации: 02.03.2018 15.10.2012 JP 2012-227838 (43) Дата публикации заявки: 10.12.2016 Бюл. № 34 2011521038 A, 21.07.2011. JP 2012140354 A, 26.07.2012. JP 2009149577 A, 09.07.2009. WO 2011138747 A1, 10.11.2011. US 2986584 A1, 30.05.1961. SU 315424 A1, 14.03.1972. (45) Опубликовано: 02.03.2018 Бюл. № 7 (85) Дата начала рассмотрения заявки PCT на национальной фазе: 15.05.2015 2 6 4 6 2 2 0 (56) Список документов, цитированных в отчете о поиске: WO 2007110978 А1, 04.10.2007. JP Приоритет(ы): (30) Конвенционный приоритет: R U 11.10.2013 (72) Автор(ы): КИТАМУРА Мицухару (JP) JP 2013/077710 (11.10.2013) C 2 C 2 (86) Заявка PCT: (87) Публикация заявки PCT: R U 2 6 4 6 2 2 0 WO 2014/061570 (24.04.2014) Адрес для переписки: ...

MEDIUM TO PROVIDE A PHYSIOLOGICAL COLD EFFECT ON THE SKIN OR MUCKS OF THE HUMAN BODY

Novel alicyclic alcohol

FIELD: chemistry. SUBSTANCE: present invention relates to a novel alicyclic alcohol compound of chemical formula: which can be used as raw material for a perfume composition and which has an excellent flowery-herblike aroma with refreshing notes. The invention also relates to a perfume composition containing the disclosed alicyclic alcohol compound and to a method for production thereof. The production method includes reacting 1-isopropyl-4-methylcyclohexene with carbon monoxide in the presence of hydrogen fluoride, reacting the obtained 4-isopropyl-1-methylcyclohexanecarboxylic acid fluoride with an alcohol to obtain a carbonyl compound of cyclohexane, followed by reducing the carbonyl compound of cyclohexane. EFFECT: obtaining a novel alicyclic alcohol compound. 3 cl, 1 tbl, 3 ex РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 2 564 417 C2 (51) МПК C07C 31/135 (2006.01) C07C 29/149 (2006.01) C11B 9/00 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ОПИСАНИЕ (21)(22) Заявка: ИЗОБРЕТЕНИЯ К ПАТЕНТУ 2013135299/04, 27.12.2011 (24) Дата начала отсчета срока действия патента: 27.12.2011 Приоритет(ы): (30) Конвенционный приоритет: (72) Автор(ы): КИТАМУРА Мицухару (JP), АТАКА Йосихару (JP), ФУКУДА Казуюки (JP) 28.12.2010 JP 2010-292938 (43) Дата публикации заявки: 10.02.2015 Бюл. № 4 R U (73) Патентообладатель(и): МИЦУБИСИ ГЭС КЕМИКАЛ КОМПАНИ, ИНК. (JP) (45) Опубликовано: 27.09.2015 Бюл. № 27 2 5 6 4 4 1 7 (56) Список документов, цитированных в отчете о поиске: US 20090163733A1, 25.06.2009. JP 01207251A, 21.08.1989. JP 01207252A, 21.08.1989. JP 2009149577A, 09.07.2009. SU 154266A1, 24.07.1963. (85) Дата начала рассмотрения заявки PCT на национальной фазе: 29.07.2013 (86) Заявка PCT: 2 5 6 4 4 1 7 R U C 2 C 2 JP 2011/080148 (27.12.2011) (87) Публикация заявки PCT: WO 2012/090976 (05.07.2012) Адрес для переписки: 129090, Москва, ул. Б. Спасская, 25, строение 3, ООО "Юридическая фирма Городисский и Партнеры" (54) НОВЫЙ АЛИЦИКЛИЧЕСКИЙ СПИРТ (57) Реферат: Настоящее ...

FLAVOR MODIFICATION PROCESS AND MODIFIER COMPOUNDS

Patent FR2312971B3

Anxiolytic tranquillising and myorelaxant compsns - contg cyclobutane deriv

Patent FR2391722B1

Compounds having sandalwood odors

本发明涉及一些檀香加香成分，它们是通式(I)的2-[全氢化-三烷基-2-亚萘基]-1-丙醇或丙醛的衍生物： 其中一条虚线表示碳碳单键，而另一条虚线表示碳碳单键或双键；X表示CH 2 OH或CHO基团；每个R 1 表示氢原子或甲基；和R 2 分开各自表示氢原子，或两个R 2 基团共同表示CH 2 基团或碳碳双键；并且所述化合物是其任一立体异构体或它们的混合物的形式。本发明涉及所述化合物在香料工业中的应用以及含有所述化合物的组合物或制品。

AQUEOUS EFFLUENT TREATMENT PROCESS

PROCEDE DE TRAITEMENT D'EFFLUENT AQUEUX L'invention concerne une formulation de floculation. L'invention concerne également le traitement de résidus miniers sous la forme d'effluents aqueux comprenant des particules solides. Le procédé de l'invention permet de séparer tout ou partie de l'eau d'un effluent aqueux comprenant des particules solides. Figure pour l'abrégé : néant The invention relates to a flocculation formulation. The invention also relates to the treatment of mining residues in the form of aqueous effluents comprising solid particles. The method of the invention makes it possible to separate all or part of the water from an aqueous effluent comprising solid particles. Figure for the abstract: none

Patent FR2092908B1

NEW ODORING SUBSTANCES WITH MUSK ODOR AND PROCESS FOR THEIR PREPARATION

L'invention concerne de nouveaux 1-acyl ou 1-hydroxyméthyl-cyclododécanes ou cyclododécènes ainsi qu'un procédé pour leur fabrication. Selon l'invention les cyclododécanes et les cyclododécènes sont de formule générale : The invention relates to novel 1-acyl or 1-hydroxymethyl-cyclododecanes or cyclododecenes and to a process for their manufacture. According to the invention, the cyclododecanes and the cyclododecenes are of general formula:

NEW SUBSTITUTE CYCLOHEXANES USEFUL AS OLFACTORY AGENTS

L'invention concerne des composés chimiques nouveaux. Il s'agit des composés de formule : The invention relates to novel chemical compounds. These are compounds of formula:

Esters contg. cyclopropane residues - with acaricidal activity

Cyclopropane derivs. of formula (I) are new:- (where Y is -CO-O-or -O-CO-; W is (CH2)m, CH=CH, CH2CH=CH or C=C, x = 1 or 2, n and N' are 0 or 1; m = 1-4; W' is alkylene, alkenylene or alkynylene; R is (i) (when x = 1) a heterocycli gp., >=10C alkyl, alkenyl or alkynyl, cycloalkyl opt. substd. by one or more lower alkyl gps., or -CHR3-CR2=CR1-A, -(CH=CH)x-A or -(CH2)x'-A, where R1, R2 and R3 are H or lower alkyl, A is phenyl, naphthyl, or cycloalkyl, each opt. mono- or polysubstd. by halogen, alkyl, alkoxy, aryl, aralkyl, aryloxy or aralkoxy, and x' is 0-10, or (ii) (when x = 2) a heterocyclic gp. or 4-6C alkylene, alkenylene, alkynylene or cycloalkylene opt. substd. by 1 or 2 alkyl or alkoxy gps. or by arylene opt. substd. by 1 or 2 alkyl, halogen or NO2 gps.; with the following provisos (a) R is not 1, 4-phenylene when W = CH2, n = 1, Y = O-CO, n' = O and X = 2; (b) R is not alkyl, alkenyl, alkynyl or aryl when W = CH2, n = 1, Y = -O-CO, n' = O and x = 1; (c) R is not alkylene, alkenylene or alkynylene when W = CH2, n = 1, Y = O-CO, n' = O and x = 2; (d) R is not alkyl, alkenyl, alkynyl, cycloalkyl or aryl when W = (CH2)m, n = 0 or 1, Y = CO-O, n' = 0 and x = 1; (e) R is not alkylene, alkenylene, alkynylene, cycloalkylene or arylene when W = (CH2)m, n = O or 1, Y = CO-O, W' = alkylene, n' = 0 or 1 and x = 2; (f) R is not cycloalkylene or arylene when W = CH2, n = 1, Y = O-CO, W' = alkylene, n' = 0 or 1 and x = 2; (g) W is CH2 and n is 1 when Y = O-CO; (h) R is not phenyl when n = 0, Y = CO-3, W' = CH2, n' = 1 and x = 0; (i) R is not styryl or cumyl when W = CH2, n = 1, Y = O-CO, n' = 0 and x = 1). Cpds. (I) are acaricides esp. active against spider mites (e.g. Tetranychus spp.) and ticks.

NEW DERIVATIVES OF NORBORNAN AND NORBORNENE, THEIR USE AND SCENTED PRODUCTS CONTAINING SAME

Process for the preparation of cyclic alcohols and esters thereof

Perfumes and fragrant compositions

Perfume systems

The present application relates to perfume raw materials, perfume delivery systems and consumer products comprising such perfume raw materials and/or such perfume delivery systems, as well as processes for making and using such perfume raw materials, perfume delivery systems and consumer products. Such perfume raw materials and compositions, including the delivery systems, disclosed herein expand the perfume communities' options as such perfume raw materials can provide variations on character and such compositions can provide desired odor profiles.

Process for the preparation of cyclocarboxylic acids and their esters

COMPOUNDS WITH BOOKED NOTE.

L'invention a trait à la chimie des fragrances et au domaine de la parfumerie. Elle concerne plus particulièrement des composés à la note boisée, répondant à la formule générale : dans laquelle : - le cycle à 6 atomes de carbone est saturé ou présente une double liaison entre les carbones C1 et C2 ou entre les carbones C1 et C6, - R est choisi parmi un groupe alkyle en C2-C5 ou alcényle en C2-C5. The invention relates to the chemistry of fragrances and the field of perfumery. It relates more particularly to compounds with a woody note, corresponding to the general formula: in which: the ring with 6 carbon atoms is saturated or has a double bond between the C1 and C2 carbons or between the C1 and C6 carbons, R is selected from C 2 -C 5 alkyl or C 2 -C 5 alkenyl.

16,16-SPIROCYCLOALKYLPROSTAGLANDIN DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USES

Improved process for preparing 7-cyclohexyl-heptanol-1 and 7-cyclohexyl-heptanediol

NEW DERIVATIVES OF 8-EXO-HYDROXYMETHYL-ENDO-TRICYCLO (5.2.1.02,6) -DECANE AND THEIR APPLICATION AS A PERFUMING AGENT

A.NOUVEAUX DERIVES DU 8-EXO-HYDROXYMETHYL-ENDO-TRICYCLO 5.2.1.0.-DECANE. B.ILS REPONDENT A LA FORMULE: (CF DESSIN DANS BOPI) DANS LAQUELLE R REPRESENTE UN GROUPE ALKYLE SATURE OU INSATURE, COMPORTANT 1 A 5 ATOMES DE CARBONE, UN GROUPE ACYLE AYANT DE 1 A 5 ATOMES DE CARBONE OU UN GROUPE GLYCIDYLE ET LE GROUPEMENT ROHC- EST RELIE A LA POSITION 8 D'UN CYCLE NORBORNANE DU COTE EXO. C.AGENTS PARFUMANTS.

Method for treating aqueous effluent

The invention concerns a flocculation formulation. The invention also concerns the treatment of mine tailings in the form of aqueous effluents comprising solid particles. With the method of the invention, it is possible to separate all or part of the water from an aqueous effluent comprising solid particles.

"perfume systems"

"sistemas de perfume"a presente invenção refere-se a matérias -primas de perfume,sistemas de liberação de perfume e produtos destinados ao consumidor que compreendem taís matérias-primas de perfume e/ou tais sitemas de liberação de perfume,assim como processos para fabricar e usar tais matérias- primas de perfume,sistemas de liberação de perfume e produtos destinados ao consumidor.tais matérias -primas de perfume e composições,incluindo os sistemas de liberação ,apresentados no presente documento,expandem as opções de perfume da comunidade,pois tais matérias-primas de perfume podem fornecer variações no caráter e tais composições podem fornecer perfis de odor desejados.

New derivatives of norbornane and norbornene, used as fragrances in perfumed products such as soap, perfume, toilet water, shampoo, detergents and deodorants

Derivatives of 2,3-dimethyl-norbornane and -norbornene with various hydroxylated or acylated and optionally unsaturated, groups at position 3 are new. Compounds of formula (I) are new. R1 = (a) -CH(CH3)OH, -CH(CH3)OCOR, -CH(CH3)XCH2CH(OH)R' or -CH(CH3)OCHR'CH2OH (if the dotted line bond is present) or (b) -CH(CH3)OH, -CH(CH3)OCOR, -COCH3, a group of formula (II), -CH(CH3)XCH2CH(OH)R', -CH2CH2XCH2CH(OH)R', -CH=CH2, -CH=CHCOR', -CH2CH2CHR'OH, -CH2CH2CHR'OCOR, -CH=CH-CH(OH)R' or -CH=CH-CHR'OCOR (if the dotted line bond is absent); R = H, methyl, ethyl, n- or iso-propyl, butyl, isobutyl, CH3(CH2)4-, (CH3)2CHCH2-, CH2=CH- or (CH3)2C=CH-; R' = H, methyl or ethyl; X = O, N or S Independent claims are also included for (1) a method for the preparation of (I) from a starting material or intermediate of formula (III); (2) perfumed products containing (I), especially perfumes, toilet water, cosmetics such as soap, shower or bath gel, shampoo and other hair hygiene products, other care products (for washing and softening) and deodorants for personal use or in the ambient air.

Cyclododecylmethyl cyclododecane-carboxylates

CYCLODODECYLMETHYL CYCLODOECANECARBOXYLATE IS DISCLOSED AS A NOVEL COMPOSITION OF MATTER WHICH MAY BE NITROSATED WITH NITROSYLSULFURIC ACID TO LAURINLACTAM. THE LACTAM IS CONVERTED BY CONVENTIONAL METHODS INTO NYLON 12. NYLON 12 IS BECOMING AN INCREASINGLY IMPORTANT POLYMER COMPOSITION FOR THE MANUFACTURE OF MOLDED ARTICLES, FIBERS AND THE LIKE. THE PRESENT INVENTION RELATES TO A NOVEL ESTER COMPOSITION OF MATTER WHICH MAY BE EMPLOYED IN THE SYNTHESIS OF LAURINLACTAM WHICH IN TURN IS USED IN THE MANFACTURE OF NYLON 12. THE PRESENT INVENTION ALSO RELATES TO A METHOD FOR MANUFACTURING SUCH ESTER COMPOSITIONS.

Cycloalkyl and cycloalkenyl prostaglandin congeners

This disclosure describes novel 15-hydroxy prostanoic acids and derivatives thereof useful as bronchodilators and hypotensive agents.

Hetero ring substituted ethane, liquid crystal material and use for device

(57)【要約】本公報は電子出願前の出願データであるた め要約のデータは記録されません。

PKC-activating compounds for the treatment of neurodegenerative diseases

The present invention relates to methods of activate an isoform of protein kinase C (PKC) for the treatment of neurological diseases including Alzheimer's disease and stroke using cyclopropanated or epoxidized derivatives of mono- and polyunsaturated fatty acids. The present invention also relates to methods of reducing neurodegeneration using cyclopropanated or epoxidized derivatives of mono- and polyunsaturated fatty acids.

compounds with a woody feel

compostos com um toque amadeirado. a invenção se refere à química das fragrâncias e ao domínio da perfumaria. ela se refere mais particularmente aos compostos com nota amadeirada, correspondentes à fómula geral (i), na qual: o ciclo com 6 átomos de carbono é saturado ou apresenta uma dupla ligação entre os carbono c1 e c2 ou entre os carbonos c1 e c6, - r é escolhido dentre um grupo alquila em c2-c5 ou alcenila em c2-c5. compounds with a woody feel. The invention relates to fragrance chemistry and the field of perfumery. it refers more particularly to woody-note compounds, corresponding to general formula (i), wherein: the 6-carbon cycle is saturated or has a double bond between c1 and c2 carbons or between c1 and c6 carbons, R is selected from a C 2 -C 5 alkyl or C 2 -C 5 alkenyl group.

Patent JPS6126766B2

Preparation of 24-alkyl analogs of cholecalciferol

Disclosed is a process for the preparation of 24-alkyl analogs of cholecalcyferol of Formula (1) having a (5E) or (5Z) configuration, wherein X represents a hydrogen atom, a hydroxy group or an OR1 group, wherein R1, R2 and R3 may be the same or different and represent groups suitable for hydrox yl protection, and R4 is a C1-6 alkyl chain or a C1-6 alkyl groups, especially for calcipotriol. The invention also provides new non-racemic compounds bein g valuable synthones for the synthesis of pharmacologically active substances.

Method for producing 2-cyclododecyl-1-propanol

The invention relates to an advantageous method for industrial production of sought-after odoriferous musk root substances 2-cyclododecyl-propanol by reacting cyclododecene in the presence of catalytic amounts of a radical initiator with an excess of propionic acid or propionic acid derivative and subsequent catalytic hydrogenation of the formed 2-cyclododecyl propionic acid or the corresponding 2-cyclododecyl propionic acid derivatives.

Novel derivatives of norbornane and norbornene, their using and aromatic products comprising thereof

Изобретение относится к новым соединениям формулы (I). где пунктиром отмеченная связь присутствует или отсутствует и где R 1 означает: - когда пунктиром отмеченная связь присутствует: -СНСН 3 ОН или -СНСН 3 OCOR или -СНСН 3 ХСН 2 CHOHR' или -СНСН 3 OCHR'СН 2 ОН или - когда пунктиром отмеченная связь отсутствует: -СНСН 3 ОН, -СНСН 3 OCOR, -СОСН 3 , -СНСН 3 XCH 2 CHOHR', -CH 2 CH 2 XCH 2 CHOHR', -СНСН 3 OCHR'СН 2 OH, -CHCHCOR', CH 2 CH 2 CHR'OH, -CH 2 CH 2 CHR'OCOR, -CHCHCHOHR' или -CHCHCHR'OCOR, где R означает Н, Me, Et, Pr, изоPr, But, изоBut, СН 3 (СН 2 ) 4 , (СН 3 ) 2 СНСН 2 , СН 2 =СН или (СН 3 ) 2 С=СН, R' означает Н, Me или Et и Х означает О, N или S. Благодаря их запаху указанные соединения представляют большой интерес для парфюмерной промышленности, косметики и продуктов для ухода и могут использоваться в качестве ароматизирующих ингредиентов для получения ароматизирующей композиции или ароматизированного изделия. 5 н. и 6 з.п. ф-лы. ÐÎÑÑÈÉÑÊÀß ÔÅÄÅÐÀÖÈß RU (19) (11) 2 288 910 (13) C2 (51) ÌÏÊ C07C 31/137 (2006.01) C07C 33/05 (2006.01) C07C 49/323 (2006.01) C07C 43/13 (2006.01) C07C 49/21 (2006.01) ÔÅÄÅÐÀËÜÍÀß ÑËÓÆÁÀ C07C 69/14 (2006.01) ÏÎ ÈÍÒÅËËÅÊÒÓÀËÜÍÎÉ ÑÎÁÑÒÂÅÍÍÎÑÒÈ,C07C 69/24 (2006.01) ÏÀÒÅÍÒÀÌ È ÒÎÂÀÐÍÛÌ ÇÍÀÊÀÌ C07D 317/12 (2006.01) C11B 9/00 (2006.01) C11D 3/50 (2006.01) (12) ÎÏÈÑÀÍÈÅ ÈÇÎÁÐÅÒÅÍÈß Ê ÏÀÒÅÍÒÓ (21), (22) Çà âêà: 2004115626/04, 23.10.2002 (30) Êîíâåíöèîííûé ïðèîðèòåò: 23.10.2001 FR 01/13663 R U (24) Äàòà íà÷àëà îòñ÷åòà ñðîêà äåéñòâè ïàòåíòà: 23.10.2002 (72) Àâòîð(û): ÌÀÍ Æàí (FR), ØÀÍÎ Æàí-Æàê (FR), ËÅ ÁÎÐÍÜ Ôàáðèñ (FR), ØШÄÅÐ Ìàðòåí (FR) (43) Äàòà ïóáëèêàöèè çà âêè: 27.10.2005 2 2 8 8 9 1 0 (73) Ïàòåíòîîáëàäàòåëü(è): Â. ÌÀÍ ÔÈÑ (FR) (45) Îïóáëèêîâàíî: 10.12.2006 Áþë. ¹ 34 (56) Ñïèñîê äîêóìåíòîâ, öèòèðîâàííûõ â îò÷åòå î ïîèñêå: US 4229600 A, 21.10.1980. FR 1381663 A, 02.11.1964. DE 4124886 A, 28.01.1993. ÕÅÉÔÈÖ Ë.À. è äð. Äóøèñòûå âåùåñòâà è äðóãèå ïðîäóêòû äë ïàðôþìåðèè. - Ì.: Õèìè , 1994. (86) ...

Process for treatment of aquous effluent

Une formulation de floculation comprenant au moins un agent de floculation, ledit agent étant un copolymère préparé à partir d'au moins un monomère non ionique et d'au moins un monomère anionique; au moins un tensioactif choisi dans le groupe constitué par les esters d'acide gras, et au moins un composé de formule (l) Où R1 = H ou un radical carboné, saturé ou insaturé, linéaire, ramifié, aromatique ou cyclique, comprenant X atomes de carbone, X étant compris entre 3 et 20, R2 est un radical carboné, saturé ou insaturé, linéaire, ramifié, aromatique ou cyclique, comprenant Y atomes de carbone, Y étant compris entre 3 et 20, et X + Y = 6 à 30. Un procédé de préparation de la formulation, un procédé de traitement d'un effluent aqueux de particules solides à l'aide de ladite formulation, et une utilisation de ladite formulation pour traiter un effluent aqueux de particules solides. A flocculating formulation comprising at least one flocculating agent, said agent being a copolymer prepared from at least one nonionic monomer and at least one anionic monomer; at least one surfactant chosen from the group consisting of fatty acid esters, and at least one compound of formula (I) where R1 = H or a carbon-based radical, saturated or unsaturated, linear, branched, aromatic or cyclic, comprising X carbon atoms, X being between 3 and 20, R2 is a carbon radical, saturated or unsaturated, linear, branched, aromatic or cyclic, comprising Y carbon atoms, Y being between 3 and 20, and X + Y = 6 to 30. A method of preparing the formulation, a method of treating an aqueous effluent of solid particles using said formulation, and a use of said formulation for treating an aqueous effluent of solid particles.

METHYL-SUBSTITUTED BICYCLO (2.2.1) HEPTANE DERIVATIVES AND THE USE THEREOF AS A FRAGRANT

Patent DE3317476C2

Patent JPS5071646A

Process for the preparation of 2 - ((1S, 2S, 5S) -6,6-dimethylbicyclo (3.1.1) hept-2-yl) -ethanol) derivatives

Novel dichloro derivatives of 16 alpha-methylpregnane, manufacture, use as drug and composition

(57)【要約】本公報は電子出願前の出願データであるた め要約のデータは記録されません。

Process for the preparation of 4-cyclohexyl-2-methyl-2-butanol

本发明涉及一种包含2‑甲基‑4‑苯基‑2‑丁醇和2‑甲基‑4‑苯基‑2‑戊醇的组合物及其制备方法。本发明还涉及包含2‑甲基‑4‑苯基‑2‑丁醇和2‑甲基‑4‑苯基‑2‑戊醇的组合物作为香料、在洗涤或清洁组合物中的用途。本发明还涉及制备4‑环己基‑2‑甲基‑2‑戊醇的方法。本发明还涉及包含4‑环己基‑2‑甲基‑2‑戊醇的组合物。本发明还涉及4‑环己基‑2‑甲基‑2‑戊醇或包含4‑环己基‑2‑甲基‑2‑戊醇的组合物作为香料、在化妆品组合物中和在洗涤或清洁组合物中的用途。

Process for the preparation of 4-cyclohexyl-2-methyl-2-butanol

The present invention relates to a process for the preparation of 4-cyclohexyl-2-methyl-2-butanol. The process involves the following steps: a) reaction of styrene with isopropanol at elevated temperature, giving 4-phenyl-2-methyl-2-butanol, and b) heterogeneous-catalytic hydrogenation of 4-phenyl-2-methyl-2-butanol over a catalyst suitable for the ring hydrogenation of aromatics.

Thiazole cardiovascular agents

Sedative and choleretic medicine

The invention relates to a gelatine coated pill containing 1-cyclo-hexyl-1-propanol. The 1-cyclohexyl-1-propanol has choleretic and sedative activity and potentiates the action of barbiturates.

Pinanes

The invention relates to novel odorants derived from formylpinane. In particular, these are compounds of the formula ##STR1## in which R represents H or C--C alkyl, for example methyl, ethyl, propyl, butyl etc., preferably methyl or ethyl, preferably methyl or ethyl, n represents 0 or 1 and the notation represents a single or double bond I.

Ruthenium complexes and their uses in processes for formation and/or hydrogenation of esters, amides and derivatives thereof

The present invention relates to novel Ruthenium catalysts and related borohydride complexes, and the use of such catalysts, inter alia, for (1) hydrogenation of amides (including polyamides) to alcohols and amines; (2) preparing amides from alcohols with amines (including the preparation of polyamides (e.g., polypeptides) by reacting dialcohols and diamines and/or by polymerization of amino alcohols); (3) hydrogenation of esters to alcohols (including hydrogenation of cyclic esters (lactones) or cyclic di-esters (di-lactones) or polyesters); (4) hydrogenation of organic carbonates (including polycarbonates) to alcohols and hydrogenation of carbamates (including polycarbamates) or urea derivatives to alcohols and amines; (5) dehydrogenative coupling of alcohols to esters; (6) hydrogenation of secondary alcohols to ketones; (7) amidation of esters (i.e., synthesis of amides from esters and amines); (8) acylation of alcohols using esters; (9) coupling of alcohols with water to form carboxylic acids; and (10) dehydrogenation of beta-amino alcohols to form pyrazines. The present invention further relates to the novel uses of certain pyridine Ruthenium catalysts.

PROCEDURE FOR OBTAINING 2-CYCLODODECIL-1-PROPANOL.

La invención se refiere a un procedimiento ventajoso para la producción industrial de 2-ciclododecil-propanol, codiciada sustancia olorosa de la raíz del almizcle, mediante la reacción de ciclododeceno en la presencia de cantidades catalíticas de un iniciador radicalar con un excedente de ácido propiónico o de un derivado del ácido propiónico y la subsecuente hidrogenación catalítica del ácido 2-ciclododecil propiónico o de los correspondientes derivados del ácido 2-ciclododecil propiónico formados. The invention relates to an advantageous process for the industrial production of 2-cyclododecyl-propanol, coveted odorous substance of musk root, by reacting cyclododecene in the presence of catalytic amounts of a radical initiator with a surplus of propionic acid or of a derivative of propionic acid and the subsequent catalytic hydrogenation of 2-cyclododecyl propionic acid or of the corresponding derivatives of 2-cyclododecyl propionic acid formed.