СПОСОБ ПОЛУЧЕНИЯ ИЗОТИОЦИАНАТОВ

FIELD: food industry. SUBSTANCE: invention refers to food industry. The method proposed envisages injection of solid byproducts of mustard oil production into a reservoir filled with water, agitation to generate a dispersed system that is subsequently heated, maintained at the heating temperature during 15 minutes and additionally treated to provide for generation of vapour phase eventually delivered for condensation and separation. The maximum content of water the solid products are mixed with in the system is 30%; the additional treatment proceeds under pressure-tight conditions. EFFECT: energy efficiency combined with the process acceleration. ÐÎÑÑÈÉÑÊÀß ÔÅÄÅÐÀÖÈß (19) RU (11) 2 346 980 (13) C1 (51) ÌÏÊ C11B 13/00 (2006.01) ÔÅÄÅÐÀËÜÍÀß ÑËÓÆÁÀ ÏÎ ÈÍÒÅËËÅÊÒÓÀËÜÍÎÉ ÑÎÁÑÒÂÅÍÍÎÑÒÈ, ÏÀÒÅÍÒÀÌ È ÒÎÂÀÐÍÛÌ ÇÍÀÊÀÌ (12) ÎÏÈÑÀÍÈÅ ÈÇÎÁÐÅÒÅÍÈß Ê ÏÀÒÅÍÒÓ (21), (22) Çà âêà: 2007138047/13, 12.10.2007 (72) Àâòîð(û): ×å Ñàí Ãóí (RU), Ãðîøåâ Âëàäèìèð Àëåêñååâè÷ (RU), Íèêèòèí Àíäðåé Åâãåíüåâè÷ (RU) (24) Äàòà íà÷àëà îòñ÷åòà ñðîêà äåéñòâè ïàòåíòà: 12.10.2007 (45) Îïóáëèêîâàíî: 20.02.2009 Áþë. ¹ 5 Àäðåñ äë ïåðåïèñêè: 400007, ã. Âîëãîãðàä, ïð. Ìåòàëëóðãîâ, ä.23, êâ.42, ïàò.ïîâ. È.Ì.Òðåíîæêèíîé, ðåã.¹ 138 äîïîëíèòåëüíîé îáðàáîòêå äë îáðàçîâàíè ïàðîâîé ôàçû ñ ïîäà÷åé ïîñëåäíåé íà êîíäåíñàöèþ è ðàçäåëåíèå. Òâåðäûå ïðîäóêòû ñìåøèâàþò ñ âîäîé, ñîäåðæàíèå êîòîðîé â ñèñòåìå íå ïðåâûøàåò 30%, à äîïîëíèòåëüíóþ îáðàáîòêó ïðîâîä ò ïîä âàêóóìîì. Èçîáðåòåíèå ïîçâîë åò ñíèçèòü ýíåðãîçàòðàòû è ñîêðàòèòü äëèòåëüíîñòü ïðîöåññà. R U 2 3 4 6 9 8 0 (57) Ðåôåðàò: Èçîáðåòåíèå îòíîñèòñ ê ïèùåâîé ïðîìûøëåííîñòè. Ñïîñîá ïðåäóñìàòðèâàåò ââåäåíèå òâåðäûõ ïîáî÷íûõ ïðîäóêòîâ ãîð÷è÷íîìàñëîáîéíîãî ïðîèçâîäñòâà â åìêîñòü ñ âîäîé ñ îáðàçîâàíèåì ïðè ïåðåìåøèâàíèè äèñïåðñíîé ñèñòåìû, êîòîðóþ ïîñëå íàãðåâà è 15-ìèíóòíîé âûäåðæêè ïðè òåìïåðàòóðå íàãðåâà ïîäâåðãàþò Ñòðàíèöà: 1 RU C 1 C 1 (54) ÑÏÎÑÎÁ ÏÎËÓ×ÅÍÈß ÈÇÎÒÈÎÖÈÀÍÀÒΠ2 3 4 6 9 8 0 (56) Ñïèñîê äîêóìåíòîâ, öèòèðîâàííûõ â îò÷åòå î ïîèñêå: RU 2196813 Ñ2, 20.01.2003. Êðàòêà ...

VERFAHREN ZUR HERSTELLUNG VON ISOTHIOCYANATEN

Fungicidal and nematocidal organic isothiocyanate prepn. - from monosubstd. formamides and alkoxycarbonyl sulphene chlorides in thionyl chloride

Organic isothiocyanates (A) are prepd. by reacting N-mono-substd. formamides, (I), with alkoxycarbonyl sulphene chlorides, (II), in the presence of thionyl chloride, pref. at 0-120 (10-80) degrees C. (A) can also be used as intermediates for prepn. of pesticides and therapeutic agents. In an example, 4-chloro-2-methyl-phenyl isothiocyanate was prepd. in 92% yield by reacting 0.1 mol 4-chloro-2-methyl formanilide with 0.11 mol ethoxycarbonyl sulphene chloride in 250 ml SOCl2 at 15 degrees C.

VERFAHREN ZUR HERSTELLUNG VON ISOTHIOCYANATEN

Verfahren zur Herstellung von Isothiocyanaten

Verfahren zur Herstellung von Isothiocyanaten

Verfahren zur Herstellung von Alkyl-isothiocyanaten

Verfahren zur Herstellung von Isothiocyanaten

PROCEDURE FOR THE PRODUCTION OF ISOTHIOCYANATEN.

СПОСОБ АНИОННОЙ ДИСПЕРСИОННОЙ ПОЛИМЕРИЗАЦИИ

FIELD: chemistry. SUBSTANCE: claimed invention relates to method for anionic dispersion polymerisation, in particular, to method of obtaining anionic highly molecular water-soluble dispersion polymer. Described is method for anionic dispersion polymerisation, in which polymerisation is improved by means of organic isothiocyanate, which includes alkylisothiocyanate, with said method including free-radical polymerisation of mixture, containing: i) water-soluble anionic ethylene-unsaturated monomer and/or water-soluble non-ionic ethylene-unsaturated monomer, ii) possibly non-ionic hydrophobic ethylene-unsaturated monomer, iii) modifier, including organic isothiocyanate, iv) stabiliser, v) initiator, vi) water-soluble salt and vii) water. EFFECT: control of polymerisation reaction rate and obtaining anionic highly molecular water-soluble polymers, useful as flocculants and, in particular, as retaining and draining additives in paper production. 9 cl, 2 ex РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 2 573 638 C2 (51) МПК C08F 2/16 (2006.01) C08G 18/70 (2006.01) C08F 220/56 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ОПИСАНИЕ (21)(22) Заявка: ИЗОБРЕТЕНИЯ К ПАТЕНТУ 2013119458/04, 14.10.2011 (24) Дата начала отсчета срока действия патента: 14.10.2011 (72) Автор(ы): КАРСЕЛЛЬЕР Роза (FI), ЮППО Ари (FI) (73) Патентообладатель(и): КЕМИРА ОЙЙ (FI) Приоритет(ы): (30) Конвенционный приоритет: R U 15.10.2010 US 61/393,420; 15.10.2010 FI 20106068 (43) Дата публикации заявки: 20.11.2014 Бюл. № 32 (56) Список документов, цитированных в отчете о поиске: CN 101402853 A, 08.04.2009. CN 101402853 A, 08.04.2009. EP 0546514 A1, 16.06.1993. EP 0546514 A1, 16.06.1993. GB 955197 A, 15.04.1964. GB 955197 A, 15.04.1964. EA 11824 B1, 30.06.2009. RU 2008144620 A, 20.05.2010. (86) Заявка PCT: C 2 C 2 (85) Дата начала рассмотрения заявки PCT на национальной фазе: 15.05.2013 FI 2011/050890 (14.10.2011) (87) Публикация заявки PCT: 2 5 7 3 6 3 8 WO 2012/049371 (19.04.2012) R U 2 5 7 ...

Carbonyl di:isothiocyanate and isothiocyanato-carbonyl isocyanate - obtd. by reaction of carbonyl halide e.g. phosgene or halo:carbonyl isocyanate with ammonium thiocyanate

In a new process for the prodn. of carbonyl psuedohalides of the formula SCN-CO-Y (I) (where Y is isothiocyanate or isocyanato), a carbonyl halide of the formula Hal(1)-CO-Hal (2) (II) (where Hal(1) and Hal(2) are F, Cl or Br and Hal (2) can also be isocyanato) is reacted with ammonium thiocyanate in the presence of an inert polar diluent at below 30 deg.C in such a way that the carbonyl halide (II) is always present in excess. The cpd. isothiocyanate-carbonyl isocyanate (Ia) of the formula SCN-CO-NCO is new and claimed. Also new and claimed is the use of carbonyl diisothiocyanate (Ib) for the prodn. of 5,6-dihydro-6-thioxo -2-(XR1)-1,3,5- thiodiazin-4-one derivs. (II) (where X is O, S or NR2; and R1 and R2 are H, open-chain or cyclic alkyl, aralkyl or aryl) and of 2-thiobuirsts of the formula (R3) (R4)-CO-NH-CS-N(R3)(R4) (III) (where R3 and R4 are H, alkyl, aralkyl or aryl or N(R3) (R4) is a heterocyclic ring). (I) are reactive substances suitable for use as intermediates e.g. pharmaceuticals, plant protection agents and materials protection agents. In particular, (Ib) is useful on intermediate for thiodiazines (II) and thiobuirets (III) useful as pharmaceuticals, microbicides, fungicides and insecticides.

Verfahren zur Herstellung aliphatischer Senfoele

Process for the production of organic isothiocyanates

Aliphatic, cycloaliphatic or aromatic isothiocyanates are prepared by reacting an isocyanide dihalide with an alkali metal or alkaline earth metal salt of hydrogen sulphide, a dithiocarbamic acid, a xanthic acid or a mercaptan. The dihalides are of the general formula R-N=CX2 wherein R represents any aliphatic, cycloaliphatic or aromatic radical and X is a halogen atom. The reaction is, in general, performed at room temperature, or slightly elevated temperatures, by reacting a solution or suspension of the salt in an organic solvent with the dihalide. Aqueous medium may also be used and it is expedient to add an emulsifier or solubilizer in this case. The examples relate to the preparation of p-chlorophenyl-, phenyl-, 2, 4, and 2, 5 dichlorophenyl-, 2,4,5 and 2,4,6 trichlorophenyl-, cyclohexyl-, 1,4 diphenylene-di-, and pentachlorophenyl-isothiocyanates. Additional isocyanide dihalide wherein R is CH3, C2H5, C12H25, 4-nitrophenyl, benzyl and naphthyl are specified. The isothiocyanates may ...

PRODUCTION OF ISOTHIOCYNATES

... 1311112 Isothiocyanates DEUTSCHE GOLDUND SILBER-SCHEIDEANSTALT 23 June 1970 [11 July 1969] 30381/70 Heading C2C Isothiocyanates of the formula RNCS (where R is an alkyl C 1-18 radical optionally substituted by alkylthio C 1-12 and/or alkoxy C 1-12 radicals; a cycloalkyl radical; an aralkyl radical; or an aryl radical optionally substituted by one or more bromine or chlorine atoms or alkyl C 1-4 or alkoxy C 1-12 radicals) are prepared by reacting 1 mole of a triazine of Formula I: (where X is an alkylthio C 1-12 , monoalkyl C 1-12 - amino or alkoxy C 1-12 radical, or an aryl radical optionally substituted by one or more halogen atoms or X is a chlorine atom) with 2 or 3 moles of a dithiocarbamate of formula RNHCSSM, where M is an alkali metal atom, the ammonium group or a valency of an alkaline earth metal, at 0-50‹ C. in the presence of water as a solvent or in a mixture of water and an organic solvent, to form the corresponding bis- or trisdithiocarbamate of the triazine which is then ...

PROCEDURE FOR THE PRODUCTION OF ISOTHIOCYANATEN.

PROCEDURE FOR THE PRODUCTION OF ISOTHIOCYANATEN

PROCEDURE FOR THE PRODUCTION OF N-ALK (EN) OXY OR N-ARYLOXY-CARBONYL-ISOTHIOCYANATEN AS WELL AS THEIR DERIVATIVES IN PRESENCE OF A N, N-DIALKYL OF ARYL AMINE AS CATALYST

PROCEDURE FOR THE PRODUCTION OF ISOTHIOCYANATEN

PROCESS FOR THE PREPARATION OF ISOTHIOCYANATES

There is disclosed a process for the preparation of isothiocyanates of formu la wherein R 1 and R 2 are each independently of the other C 1-C 6alkyl and R 3 , R 4 and R 5 are each independently of the other hydrogen, halogen, C 1-C 4alkyl, C 1-C 4alkoxy, trifluoro- methyl or nitro, which process comprises reacting an amine of formula with ammonium thiocyanate or an alkali metal thiocyanate, in the presence of acid and an inert solvent, to the thiourea of formula and cleaving said thiourea by heating. The essential feature of this process consists in carrying out the reaction of the amine of the above formula with ammonium thiocyanate or an alkali metal thiocyanate in the presence of 0.5-5% by weight of water, based on the total weight of the reaction mixture. The isothiocyanates of the above formula are intermediates for the synthesis of pesticidal compounds.

PROCESS FOR THE PREPARATION OF ISOTHIOCYANATES

PS/5-17870/= Process for the preparation of isothiocyanates There is disclosed a process for the preparation of isothiocyanates of formula wherein R1 and R2 are each independently of the other Cl-C6alkyl and R3, R4 and R5 are each independently of the other hydrogen, halogen, Cl-C4alkyl, Cl-C4alkoxy, trifluoro-methyl or nitro, which process comprises reacting an amine of formula with ammonium thiocyanate or an alkali metal thiocyanate, in the presence of acid and an inert solvent, to the thiourea of forrnula and cleaving said thiourea by heating The essential feature of this process consists in carrying out the reaction of the amine of the above formula with ammonium thiocyanate or an alkali metal thiocyanate in the presence of 0.5-5% by weight of water, based on the total weight of the reaction mixture. The isothiocyanates of the above formula are intermediates for the synthesis of pesticidal compounds.

СПОСОБ АНИОННОЙ ДИСПЕРСИОННОЙ ПОЛИМЕРИЗАЦИИ

1. Способ анионной дисперсионной полимеризации, отличающийся тем, что полимеризацию улучшают с помощью органического изотиоцианата.2. Способ по п.1, отличающийся тем, что органический изотиоцианат включает алкил-, алкенил-, арил- или аралкилизотиоцианат, предпочтительно алкилизотиоцианат, такой как метилизотиоцианат, этилизотиоцианат или пропилизотиоцианат.3. Способ по п.1, отличающийся тем, что количество органического изотиоцианата составляет от 0,1 до 1,0%, предпочтительно от 0,3 до 0,8 мас.% от общей массы мономеров.4. Способ по п.1 для получения анионного дисперсионного полимера, включающий свободно-радикальную полимеризацию смеси, содержащей:i) водорастворимый анионный этилен-ненасыщенный мономер и/или водорастворимый неионный этилен-ненасыщенный мономер,ii) возможно неионный гидрофобный этилен-ненасыщенный мономер,iii) модификатор, включающий органический изотиоцианат,iv) стабилизатор,v) инициатор,vi) водорастворимую соль иvii) воду.5. Способ по п.4, отличающийся тем, что водорастворимый анионный мономер включает акриловую кислоту, метакриловую кислоту, 2-акриламидо-2-метил-1-пропансульфоновую кислоту, акриламидометилмасляную кислоту, малеиновую кислоту, фумаровую кислоту, итаконовую кислоту, винилсульфокислоту, стиролсульфокислоту, винилфосфоновую кислоту, аллилсульфокислоту, аллилфосфоновую кислоту, сульфометилированный акриламид, фосфонометилированный акриламид или водорастворимую соль щелочного металла, щелочноземельного металла или аммониевую соль, а водорастворимый неионный мономер включает акриламид, метакриламид, N-изопропилакриламид, N-трет-бутилакриламид или N-метилолакриламид.6. Способ по п.4, отл РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (51) МПК C08F 2/16 (11) (13) 2013 119 458 A (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ЗАЯВКА НА ИЗОБРЕТЕНИЕ (21)(22) Заявка: 2013119458/04, 14.10.2011 (71) Заявитель(и): КЕМИРА ОЙЙ (FI) Приоритет(ы): (30) Конвенционный приоритет: (72) Автор(ы): КАРСЕЛЛЬЕР Роза (FI), ЮППО Ари (FI) 15.10.2010 US 61/393, ...

Verfahren zur Herstellung von Isothiocyanaten.

Procedure for the production of Isothiocyanaten

METHOD OF PREPARATION Of ISOTHIOCYANATES

PRODUCTION OF ISOTHIOCYNATES

Verfahren zur Herstellung von N-Alk(en)oxy- oder N-Aryloxy-carbonyl-isothiocyanaten sowie deren Derivate in Anwesenheit eines N,N-Dialkyl-arylamins als Katalysator

VERFAHREN ZUR HERSTELLUNG VON ISOTHIOCYANATEN

Process for the manufacture of alkyl isothiocyanates

Alkyl isothiocyanates are prepared by reacting phosgene with an aqueous solution of a sodium, potassium or ammonium N-alkyl dithiocarbamate. Sodium N-methyl and N-ethyl dithiocarbamates are prepared by reacting together carbon disulphide, sodium hydroxide and methylamine or ethylamine as appropriate.

PROCESS FOR PRODUCTION OF ISOTHIOCYANATES

PROCESS FOR PRODUCTION OF ISOTHIOCYANATES OF THE PRESENT INVENTION Isothiocyanates are formed by oxidizing, with gaseous oxygen or air, in the presence of a metal oxidation catalyst a dithiocarbamate with appropriate control of the pH of the reaction medium to suppress the formation of by-products. Optionally a quaternary ammonium halide catalyst can be used to increase product yield.

ANIONIC DISPERSION POLYMERIZATION PROCESS

The invention provides an anionic dispersion polymerization process, wherein the polymerization is improved by an organic isothiocyanate, such as methyl isothiocyanate.

METHOD OF PREPARATION Of ISOTHIOCYANATES

PREPARATION OF SUBSTITUTED ISOTHIOCYANATES

Organic cyanogen compounds and their application

Alkyl or cycloalkyl thiocyanates and isothiocyanates in which the hydrocarbon group has at least 6 carbon atoms, are obtained by the action of an alkali metal salt of thiocyanic acid on an inorganic ester of a higher alcohol, or by the action of cyanogen halide on the metal salt of a mercaptan; the products are useful as insecticides and fungicides. The hydrocarbon radicle may contain a straight or branched chain, saturated or unsaturated. The preparation of lauryl thiocyanate by converting lauryl alcohol to the chloride and treating this with sodium thiocyanate in ethyl alcohol is described in an example. Other lauryl esters specified include the bromide, sulphates, and phosphate, and the reaction may be accelerated by the use of finely divided copper as a catalyst. The starting material may be a crude lauryl alcohol containing octyl, decyl, tetradecyl alcohols and other homologues, obtained by the hydrogenation of vegetable oils such as coconut oil, or the free fatty acids, and gives ...

Process for the manufacture of isothiocyanate sulphonic acids

Aromatic and heterocyclic isothiocyanate sulphonic acids are prepared by reacting aminosulphonic acids of the aromatic or heterocyclic series with thiophosgene in an aqueous mineral acid medium. Thus aminobenzenesulphonic acids, aminonaphthalene-sulphonic acids, aminoazobenzene-sulphonic acids, aminocarbazole-sulphonic acids which may be substituted by halogen, alkyl, alkoxy, hydroxy, or acylamino substituents, may be so treated, advantageously at moderate temperatures and using equimolecular proportions of the reacting components. A neutrally reacting medium may be initially employed, the hydrochloric acid liberated during reaction then furnishing the mineral acid medium. Compounds containing substituents o- or pto the amino group and which could give rise to side reactions are modified by rendering such substituents inactive; thus a hydroxy group is etherified or an amino group acylated prior to reaction. The products react with primary or secondary amines to give symmetrical or asymmetrical ...

PROCESS FOR THE PRODUCTION OF ISOTHIOCYANATES

Process for manufacture of isothiocyanates

Preparation of substituted isothiocyanates

Substituted isothiocyanates, such as alkyl isothiocyanates, e.g. ethyl isothiocyanate, are prepared by contacting a reaction admixture formed from an amine, such as a primary amine, carbon disulfide and an aqueous alkali metal hydroxide solution with gaseous oxygen in the presence of a solvent and a catalyst to produce a substituted isothiocyanate, such as ethyl isothiocyanate when ethylamine is employed to form the reaction admixture. An embodiment of the invention is indicated by the chemical equation: H2O C2H5HN2 + CS2 + NaOH -> H2O O2/C + C2H5NHSCSNa -> C2H5NCS CHCl3+ inorg. S compounds ...

Process for production of isothiocyanates

Isothiocyanates are formed by oxidizing, with gaseous oxygen or air, in the presence of a metal oxidation catalyst a dithiocarbamate with appropriate control of the pH of the reaction medium to suppress the formation of by-products. Optionally a quaternary ammonium halide catalyst can be used to increase product yield.

Process for the production of isothiocyanates

Isothiocyanates of the general formula R-N=C=S, wherein R is an aliphatic, cycloaliphatic, araliphatic, aromatic or heterocyclic radical, which may be substituted by halogen atoms or alkyl, haloalkyl and/or nitro groups, are produced by heating an isocyanide dihalide of the general formula wherein X is a halogen atom, with a pentasulphide of the general formula Y2S5, wherein Y is a phosphorus, arsenic or antimony atom, in the presence of an inert solvent. The reactants are expediently added to the inert solvent, the mixture heated, generally at 80 DEG -220 DEG C. and preferably at 100 DEG -150 DEG C., until the pentasulphide is completely dissolved and the isothiocyanate isolated by distillation. Said isothiocyanates have nenatocidal properties (see Division A5). Specification 942,520 is referred to.ALSO:Isothiocyanates of the general formula-R-N=C=S, wherein R is an aliphatic, cycloaliphatic, araliphatic, aromatic or heterocyclic radical, which may be substituted by ...

Preparation of isothiocyanates organic starting from isocyanates

Method of preparation of isothiocyanates

Aliphatic Isothiocyanates and their preparation

Verfahren zur Darstellung von Isothiocyanatsulfonsaeuren

Improvements relating to the production of organic isothiocyanates

An organic isothiocyanate is made by heating an organic isocyanate having no active hydrogen-containing substituents which are reactive with isocyanato groups with at least one molecule of carbon disulphide for each isocyanato group at a temperature of 100 DEG to 400 DEG C. in the presence as catalyst of 0.01 to 10.0% by weight, reckoned on the isocyanate, of a substituted phospholine having the formula: a substituted phospholidine having the formula: or a phosphonate ester having the formula: wherein a, b, c and d, each independently, represent a hydrogen or halogen atom or an alkyl group of 1 to 4 carbons, alkenyl group of 1 to 4 carbons, phenyl or cyclohexyl radical, or two together represent a polymethylene group which, together with two adjacent carbon atoms in the heterocyclic ring, forms a cycloaliphatic ring; R is an alkyl of 1 to 4 carbons or a phenyl radical, or a substituted phenyl radical in which the substituents are ...

ANIONIC DISPERSION POLYMERIZATION PROCESS

The present invention relates to an anionic dispersion polymerization process, particularly a process for the preparation of an anionic, high molecular weight water soluble dispersion polymer. High molecular weight water-soluble polymers are useful in the manufacture of paper. They act as flocculants, forming large flocs which deposit on the sheet, and aid in the dewatering of the sheet. According to the present invention it was surprisingly found that by introducing an organic isothiocyanate into an anionic dispersion polymerization process as an improver, it is possible to control the polymerization reaction speed and to obtain anionic, high molecular weight water soluble polymers which are useful as flocculants and especially as retention and drainage aids in the manufacture of paper. It is believed that the organic isothiocyanate makes it possible to control the polymerization reaction speed to get a stabile dispersion and to tailor the various properties of the final polymer.

Manufactoring process of isothiocyanates

PROCESS FOR THE SYNTHESIS OF BETA-AMINOCARBONYLS

The present application provides processes and intermediates useful in the production of β- aminocarbonyl- or β-aminothiocarbonyl-containing compounds. Provided herein is a process for synthesizing β-aminocarbonyl- or β-aminothiocarbonyl-containing compounds from an alkene and a hydrazone. Also provided herein is a process for synthesizing β-aminocarbonyl- or β-aminothiocarbonyl-containing compounds from an alkene and a hydrazine. The present application further provides intermediate aminoisocyanate and iminoisocyanate compounds, and methods for synthesizing the starting hydrazone and hydrazine compounds.

Production of organic isothiocyanates

Organic mono- and di-isothiocyanates are prepared by the oxidation, using chloramine-T as the oxidizing agent, of an alkali metal mono-(dithiocarbamate) salt of the formula R1NH. CSSM or an alkali metal bis-(dithiocarbamate) salt having the general formula in which R1 and R are aliphatic, cycloaliphatic, aromatic or mixed aliphatic-aromatic groups and M is an alkali metal. The alkali metal dithiocarbamate salt may be produced by reacting a monoamine of the formula R1-NH2 or a diamine of the formula NH2-R-NH2 with carbon disulphide and a caustic alkali. Examples are given.

SELECTIVE ADDITION OF THIOLS TO ALLYLIC ISOCYANATES AND ISOTHIOCYANATES

FLUESSIGKRISTALLINE SENFOELE

Verfahren zur Herstellung organischer Isothiocyanate

PREPARATION OF SUBSTITUTED ISOTHIOCYANATES

Preparation of esters of isothiocyanic acid

Verfahren zur Herstellung von Isothiocyanaten

FLUESSIGKRISTALLINE ISOTHIOCYANATE-DERIVATE.

Verfahren zur Herstellung von N-Alk(en)oxy- oder N-Aryloxy-carbonyl-isothiocyanaten sowie deren Derivate in Anwesenheit eines N,N-Dialkyl-arylamins als Katalysator

ISOTHIOCYANATE, PREPARATION METHOD THEREFOR, AND USE AGAINST CANCER

An isothiocyanate having the following structural formula (I). The isothiocyanate synthesis processing technique is as follows: obtained by using conventional organic bases, carbon disulfide, and acetyl chloride to react in a low temperature or room temperature environment. The isothiocyanate has substantial damaging effect on tumor cells.

Verfahren zur Herstellung von organischen Isothiocyanaten

Verfahren zur Herstellung von Isothiocyanaten

Carbonyl-thiocarbonyl-amine derivs. prodn. - by reaction of 5,6-di:hydro-6-thioxo-4h-1,3,5-thiadiazin-4-one cpds. with active hydrogen cpds.

In a new process for the prodn. of carbonyl-thiocarbonyl-amine derivs. ACONHSCB (I) a 1,3,5-thiadiazine deriv. (II) is reacted with an active hydrogen cpd. R7-XH (III), possibly with simultaneous elimination of HSCN, in the presence of an inert solvent at ca 0-150 deg.C (where A is -YR4 or -NH-CS-YR6; Y is O, S or NR5; R4 is alkyl, aralkyl or aryl or, when Y is NR5, also H; R5 is H, alkyl, aralkyl or aryl; R6 is aryl; B is XR3; X is O, S or NR2; R3 is alkyl, aralkyl or aryl or when X is NR2, also H; or -XR3 is morpholino, piperidino, piperazino or thiomorpholino; R2 is H, alkylaralkyl or aryl; or A and B are each morpholino, piperidino, piperazino or thiomorpholine; or A and B together form a residue -NR8-CS-NH- in which R8 is aralkyl or aryl; and R7 is R4 and R6, or -YR7 is morpholine, piperazino, piperidino or thiomorpholino; or, when X is NH, -YR7 is an N-R3-N- (5,6-dihydro-4-oxo-6- thioxo-4H-1,3,5 thiodiazin-2-yl) amino residue). (I) are useful as pharmaceuticals, microbicides, fungicides ...

CРЕДСТВО ДЛЯ ПРОФИЛАКТИКИ И/ИЛИ ЛЕЧЕНИЯ ОПУХОЛЕВЫХ ЗАБОЛЕВАНИЙ

Изобретение относится к новому средству, представляющему собой производные роданина, которое обладает профилактическим, антипролиферативным и антиметастатическим действием. Указанное средство может найти применение в медицине и фармакологии для профилактики и/или лечения опухолевых заболеваний различной локализации.

Verfahren zur Herstellung von Isothiocyanaten

알콕시카르보닐 이소티오시아네이트의 제조 방법

... 물 및 촉매의 양을 제어함으로써 톨루엔 중에서 알킬 클로로포르메이트 및 티오시아네이트로부터 알콕시카르보닐 이소티오시아네이트를 제조하는 방법이 본원에 제공된다.

processo de polimerização de dispersão aniônica.

Verfahren zur Darstellung von Senfoelen

Procédé de préparation d'isothiocyanates

Preparation of organic thiocyanates and isothiocyanates

PROCEDE POUR LA PREPARATION D'ISOTHIOCYANATES

METHOD FOR PRODUCING ISOTHIOCYANATES

Способ может быть использован в пищевой промышленности. Для получения изотиоцианатов к твердым побочным продуктам горчично-маслобойного производства при интенсивном перемешивании добавляют не более, чем 30 % воды, при температуре 45-50°C полученную массу выдерживают в течение 15 минут. Эфирные горчичные масла выделяют с водяным паром под вакуумом. После конденсации пара проводят разделение масел с водой.

Verfahren zur Herstellung von Isothiocyanaten

PROCESS FOR PREPARING ALKOXYCARBONYL ISOTHIOCYANATE

Method of preparation of isothiocyanates

METHOD FOR THE PRODUCTION OF ISOTHIOCYANATES AND PRODUCTS OBTAINED ACCORDING TO SAID METHOD

Isorhodanate, and preparation method and anticancer application thereof

The invention provides a series of novel isorhodanate derivatives. The isorhodanate derivatives are characterized by having a general structural formula as described in the specification. The invention also provides a process route for simple and rapid synthesis of isorhodanate. The series of novel isorhodanate derivatives can be prepared from conventional organic base, carbon disulfide and acetyl chloride at low temperature or room temperature; moreover, separation and purification of the isorhodanate derivatives are simple and easily practicable, and yield of the isorhodanate derivatives is high. The series of novel isorhodanate derivatives exert obvious killing effects on tumor cells; and in particular, a compound 1 and a compound 2 have obvious inhibitory activity on human pancreatic cancer, stomach cancer, intestinal cancer, nasopharyngeal cancer, liver cancer, glioma, anti-cis-platinum lung cancer, leukemia and melanoma.

Process for the preparation of isothiocyanates

There is disclosed a process for the preparation of isothiocyanates of formula wherein R1 and R2 are each independently of the other C1-C6alkyl and R3, R4 and R5 are each independently of the other hydrogen, halogen, C1-C4alkyl, C1-C4alkoxy, trifluoromethyl or nitro, which process comprises an amine of formula with ammonium thiocyanate or an alkali metal thiocyanate, in the presence of acid and an inert solvent, to the thiourea of formula and cleaving said thiourea by heating. The essential feature of this process consists in carrying out the reaction of the amine of the above formula with ammonium thiocyanate or an alkali metal thiocyanate in the presence of 0.5-5% by weight of water, based on the total weight of the reaction mixture. The isothiocyanates of the above formula are intermediates for the synthesis of pesticidal compounds.

Processo para produção de isotiocianatos de n-alqu(en)óxi(ouarilóxi)cabonila e seus derivados na presença de catalisador de n,n-dialquilarilamina

Liquid-crystalline mustard oils

Mustard oils of the formula I R--(A.sup.1 --Z.sup.1).sub.n --A.sup.2 --Z.sup.2 --A.sup.3 --NCS in which A 1 , A 2 , A 3 , R, Z 1 , Z 2 and n have the meaning specified in claim 1 can be used as components of liquid-crystalline phases.

Method for preparing aliphatic and cycloaliphatic isothiocyanates

A method for preparing aliphatic and cycloaliphatic isothiocyanates comprising reacting a selected aliphatic or cycloaliphatic nitro compound with a sulfur containing carbon compound in the presence of a metal carbonyl catalyst.

processo para produção de isotiocianatos de n-alqu(en)óxi(ou arilóxi)cabonila e seus derivados na presença de catalisador de n,n-dialqu(en)ilamina.

Preparation of substituted isothiocyanates

Substituted isothiocyanates, such as alkyl isothiocyanates, e.g. ethyl isothiocyanate, are prepared by contacting a reaction admixture formed from an amine, such as a primary amine, and carbon disulfide with gaseous oxygen. The contacting of the reaction admixture with gaseous oxygen is carried out in the presence of a metal, such as manganese (Mn<++> ), iron (Fe<+++>), copper (Cu<++> ), zinc (Zn<++> ), nickel (Ni<++> ) and cobalt (Co<++> ), as an oxidation catalyst. The reaction admixture containing the amine and carbon disulfide might be an aqueous or non-aqueous reaction admixture. In the preparation of the non-aqueous reaction admixture the amine, together with the carbon disulfide employed in the make-up of the reaction admixture includes a non-aqueous, preferably a water-immiscible solvent, such as methylene chloride, benzene or carbon tetrachloride. An embodiment of this invention is indicated by the chemical equation: MnCl2 C2H5NH2 + CS2 O2 C2H5NCS + S + H2O CCl4 In the above-indicated ...

PROCESS FOR THE PREPARATION OF ISOTHIOCYANATES

PROCEDE DE FABRICATION D'ISOTHIOCYANATES ET PRODUITS OBTENUS SUIVANT CE PROCEDE

Preparation of substituted isothiocyanates

In the above indicated chemical equation activated carbon C is employed as the oxidation catalyst and the reaction is carried out in the presence of a solvent, such as carbon tetrachloride. Substituted isothiocyanates, such as alkyl isothiocyanates, e.g. ethyl isothiocyanate, are prepared by reacting an amine, such as a primary amine, and carbon disulfide with gaseous oxygen and desirably in the presence of a catalyst to produce a substituted isothiocyanate, such as ethyl isothiocyanate when ethylamine is employed in the reaction. An embodiment of the invention is indicated by the chemical equation:

Method for preparing aliphatic and cycloaliphatic isothiocyanates

A method for preparing aliphatic and cycloaliphatic isothiocyanates comprising reacting a selected aliphatic or cycloaliphatic nitro compound with a sulfur containing carbon compound in the presence of a metal carbonyl catalyst.

Preparation of alkyl thiosemicarbazides

The present invention relates to a process for the preparation of alkyl semicarbazides by reaction of a dithiocarbamate and hydrazine in a weakly basic reaction media using a metal rearrangement catalyst.

Anionic dispersion polymerization process

The invention provides an anionic dispersion polymerization process, wherein the polymerization is improved by an organic isothiocyanate, such as methyl isothiocyanate.

Process for the production of isothiocyanates

Isothiocyanates of the formula (I) r -- n=c=s (i) in which R is a straight or branched alkyl group with 1 to 18 carbon atoms, preferably methyl, and wherein the alkyl group can be substituted once or more by --OH, --OR1 or --SR1 and where R1 is an alkyl group of 1 to 6 carbon atoms or R is cycloalkyl with 3 to 8 carbon atoms, benzyl or phenyl in which the aromatic nucleus can be substituted once or more by a chlorine atom, a bromine atom, a hydroxyl group, or --R1, --OR1 or --SR1 or R is a pyridyl or thiazolyl group prepared by reacting (1) a dithiocarbamate of the general formula (II) см. иллюстрацию в PDF-документе where R is as defined above and Me is an alkali atom, one valence of an alkaline earth metal atom or the ammonium group whose hydrogen atoms can be substituted by R with (2) a cyanogen halide, preferably cyanogen chloride, in the presence of water. There is employed one mole of a dithiocarbamate of formula II as a 5 to 50 weight % aqueous solution in the presence of an inert ...

Process for the production of isothiocyanates

Isothiocyanates of the formula (I) R - N=C=S(I) in which R is a straight or branched alkyl group with 1 to 18 carbon atoms, preferably methyl, and wherein the alkyl group can be substituted once or more by -OH, -OR1 or -SR1 and where R1 is an alkyl group of 1 to 6 carbon atoms or R is cycloalkyl with 3 to 8 carbon atoms, benzyl or phenyl in which the aromatic nucleus can be substituted once or more by a chlorine atom, a bromine atom, a hydroxyl group, or -R1, -OR1 or -SR1 or R is a pyridyl or thiazolyl group prepared by reacting (1) a dithiocarbamate of the general formula (II) (II) where R is as defined above and Me is an alkali atom, one valence of an alkaline earth metal atom or the ammonium group whose hydrogen atoms can be substituted by R with (2) a cyanogen halide, preferably cyanogen chloride, in the presence of water. There is employed one mole of a dithiocarbamate of formula II as a 5 to 50 weight % aqueous solution in the presence of an inert organic solvent which is ...

Process for manufacture of N-alkoxy carbonyl isothiocyanates and their derivatives in the presence of N,N-dialkylarylamine catalyst

The present invention provides a process for making N-alk(en)oxy(or aryloxy)carbonyl isothiocyanate derivatives by reacting a haloformate with a thiocyanate, in the presence of an aqueous solvent or an organic solvent and a catalytic amount of a N,N-dialk(en)ylarylamine, to produce a N-alkoxy (or aryloxy)carbonyl isothiocyanate intermediate product, wherein the intermediate product is converted to a N-alk(en)oxy(or aryloxy)carbonyl isothiocyanate derivative in high yield and purity. The invention further provides a process for making N-alk(en)oxy (or aryloxy)carbonyl isothiocyanates by reacting a haloformate with a thiocyanate, in the presence of an aqueous solvent or an organic solvent and a catalytic amount of a N,N-dialk(en)ylarylamine.

processo de polimerização de dispersão aniônica.

Anionic dispersion polymerization process

The invention provides an anionic dispersion polymerization process, wherein the polymerization is improved by an organic isothiocyanate, such as methyl isothiocyanate.

Anionic dispersion polymerization process

Isothiocyanate derivative and preparation method and application thereof

本发明提供了一种异硫氰酸酯衍生物及其制备方法和应用，该异硫氰酸酯衍生物的分子结构中含有硫代酰胺、硫脲或硫代酰胺酯等亲油基团和羧基亲水基团，其制备方法是使用异硫氰酸酯与醇类、胺类、硫醇或酚类化合物反应得到，该制备方法简单，制备的异硫氰酸酯衍生物作为非钼硫化矿抑制剂应用于硫化钼矿与非钼硫化矿的浮选分离，能有效实现硫化钼矿与硫化铜矿、方铅矿、闪锌矿、黄铁矿、硫化铋矿等分离，提高钼精矿的品位。

Dithiocarbamic acid esters

Procedure for the preparation of a cysteine and isotlocyanate cleavable dithiocarbonic acid ester of formula I **(See formula)** in which R stands for an optionally substituted aliphatic or aromatic radical, characterized in that an aqueous solution of cysteine with equimolar dose of an alcoholic solution of isothiocyanate is mixed under certain agitation and under neutral reaction conditions, the mixture is left to stand at room temperature for 2 to 3 days with occasional stirring and then isolates the precipitated dithiocarbamic acid ester. (Machine-translation by Google Translate, not legally binding)

Patent PL81800B1

Process for the preparation of isothiocyanates

Process for the preparation of isothiocyanates

There is provided a process for the preparation of isothiocyanates of the formula in which R₁ and R₂ independently of one another are each C₁-C₆-alkyl and R₃, R₄ and R₅ are each hydrogen, halogen, C₁-C₄alkyl, C₁-C₄alkoxy, trifluoromethyl or nitro, represent independently of one another, is described based on the reaction an amine of formula with ammonium or alkali metal thiocyanate in the presence of acid and an inert solvent to thiourea of ​​formula and the thermal decomposition of this thiourea based. The essential feature of the process is that the reaction of the amine of the above formula with ammonium or alkali metal thiocyanate in the presence of 0.5-5 wt.% Of water based on the total weight of the reaction mixture is carried out. The isothiocyanates of the above formula are intermediates for the preparation of pesticidally active compounds.

New thiosemi-carbazones and their preparation

Process for converting primary amines to isothiocyanates

Liquid crystal isothiocyanate derivatives

Isothiocyanate derivatives can be used as components of liquid crystal phases.

Process for manufacturing n-alk(en)oxy (or aryloxy)carbonyl isothiocyanate derivatives in the presence of n,n-dialkylarylamine catalyst

一种一锅制备酰胺基异硫氰酸酯/酰胺基硫脲类化合物的方法

本发明公开了一种一锅制备酰胺基异硫氰酸酯/酰胺基硫脲类化合物的方法。本发明通过取异腈类化合物和酰肼类化合物混合，加入有机溶剂，溶解后加入二硫化碳，搅拌反应，制得酰胺基异硫氰酸酯类化合物；取异腈类化合物、胺类化合物混合，加入有机溶剂，溶解后加入二硫化碳，第一次搅拌反应；再加入酰肼类化合物，第二次搅拌反应，制得酰胺基硫脲类化合物。本发明所用单体均为工业原料，成本低，还可进行大规模克级生产；反应操作简单，效率高，单体适用性广泛，在室温和空气的条件下就可进行，且无有毒有害副产物产生；推动酰胺基异硫氰酸酯及酰胺基硫脲类化合物的进一步发展。

一种一锅制备酰胺基异硫氰酸酯/酰胺基硫脲类化合物的方法

本发明公开了一种一锅制备酰胺基异硫氰酸酯/酰胺基硫脲类化合物的方法。本发明通过取异腈类化合物和酰肼类化合物混合，加入有机溶剂，溶解后加入二硫化碳，搅拌反应，制得酰胺基异硫氰酸酯类化合物；取异腈类化合物、胺类化合物混合，加入有机溶剂，溶解后加入二硫化碳，第一次搅拌反应；再加入酰肼类化合物，第二次搅拌反应，制得酰胺基硫脲类化合物。本发明所用单体均为工业原料，成本低，还可进行大规模克级生产；反应操作简单，效率高，单体适用性广泛，在室温和空气的条件下就可进行，且无有毒有害副产物产生；推动酰胺基异硫氰酸酯及酰胺基硫脲类化合物的进一步发展。

Método para la producción, extracción, aislamiento y purificación de isotiocianatos a partir de glucosinolatos

La presente invención se relaciona con un método o proceso de extracción y purificación de isotiocianatos a partir de glucosinolatos, en donde el método comprende las etapas de: Extracción acuosa de glucosinolatos a partir de material vegetal que los contengan. Adsorción de Glucosinolatos a la fase de intercambio aniónico de la resina de modo mixta. Producción de Isotiocianatos mediante la hidrolisis de los Glucosinolatos por mirosinasa; Simultanea Adsorción de los isotiocianatos a la fase reversa de la resina de modo mixta y la elusión de Isotiocianatos de la resina de modo mixta.

Verfahren zur herstellung von n-alk(en)oxy- oder n-aryloxy-carbonyl-isothiocyanaten sowie deren derivate in anwesenheit eines n,n-dialkyl- arylamins als katalysator

Metodo para la produccion, extraccion, aislamiento y purificacion de isotiocianatos a partir de glucosinolatos

Referido a un metodo para la produccion, extraccion, alisamiento y purificacion de isotiocianatos a partir de glucosinolatos caracterizado porque el metodo comprende las etapas de: a) Seleccionar el material vegetal con alto contenido de glucosinolatos y someterlo a secado; b) Pulverizar; c) Pesar y escaldar el polvo con solucion acuosa; d) Precipitar y separar proteinas mediante centrifugacion y/o adicion de reactivos quimicos de precipitacion de proteinas; e) Poner en contacto dicha mezcla o extracto acuoso o sobrenadante de glucosinolatos con una resina de modo mixto con capacidad de intercambio ionico e intercambio de fase hidrofobica durante un tiempo suficiente para unir selectivamente los glucosinolatos a la resina; f) Transformar los glucosinolatos mediante hidrolisis enzimatica de los mismos unidos a la resina de modo mixto de la columna mediante la adicion de una solucion alcoholica y una cantidad reducida de solvente organico que contiene disuelta la enzima mirosinasa por un tiempo para producir los isotiocianatos y liberarlos de la union ionica con la resina de modo mixto y son simultaneamente adsorbidos por la fase reversa de dicha resina; g) Lavar la columna con agua para eliminar la mirosinasa y la glucosa producida por la hidrolisis de glucosinolatos; y h) Lavar la columna con un solvente organico para eluir y recuperar los isotiocianatos.

Adamantane isocyanate and isothiocyanate

Verfahren zur Herstellung von Dihydrodicyclopentadienylamin

New sulphur compounds and bactericidal and fungicidal compositions

The invention comprises bis (thiocyanomethyl) sulphide and the corresponding sulphoxide and sulphone. The sulphide may be prepared by reacting an inorganic thiocyanate with a bis (halomethyl) sulphide in an aqueous medium. The inorganic thiocyanate may be an alkali metal, ammonium or alkaline earth metal thiocyanate and is preferably used in the form of a saturated aqueous solution containing an excess of thiocyanate over the theoretical quantity: a reaction temperature of between 5 DEG and 60 DEG C. is preferred. The sulphoxide may be prepared by oxidation of the sulphide and the sulphone by oxidation of the sulphide or sulphoxide. In each oxidation, hydrogen peroxide as an organic per-acid may be used, preferably at 20 DEG -40 DEG C. and if desired in an organic solvent medium. In examples: (1) bis (chloromethyl) sulphite is added dropwise to an aqueous solution of excess potassium thiocyanate and the resulting bis (thiocyanomethyl) sulphite is filtered off and purified by extraction with boiling benzene; (2) the sulphide is oxidised to the sulphoxide by means of aqueous H2O2 in acetic acid; (3) the sulphide is oxidised to the sulphone by peracetic acid in acetone. The sulphoxide and sulphone may be used as active ingredients in fungicidal and bactericidal compositions (see Groups VI and VIII). U.S.A. Specification 2,077,478 is referred to.ALSO:Fungicidal compositions having bactericidal activity comprise bis (thiocyano methyl) sulphoxide or the corresponding sulphone a the active ingredient and a fungicide adjuvant. The compositions may be in solid or liquid form and comprise inert solids, organic liquids or anionic-, cationic- or non-ionic-surface active agents. Adjuvants specified in examples are talc, fullers earth, fine silica, methyl cellulose, alkylated naphthalene sodium sulphonate, sodium lignin sulphonate, atta pulgite, glycol, acetone, water, and Rhodamine dye.

Verfahren zur Herstellung von gegebenenfalls substituierten Aminen des Norbornans durch saure Hydrolyse der entsprechenden Isothiocyanate

Process for manufacture of n-alk(en)oxy(or aryloxy) carbonyl isothiocyanates and their derivatives in the presence of n,n -dialkylarylamine catalyst

A method of new black mustard oils

液晶カラシ油化合物

(57)【要約】本公報は電子出願前の出願データであるため要約のデータは記録されません。

Verfahren zur Herstellung von neuen Thiocolchicin-Derivaten

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一种一锅制备酰胺基异硫氰酸酯/酰胺基硫脲类化合物的方法

本发明公开了一种一锅制备酰胺基异硫氰酸酯/酰胺基硫脲类化合物的方法。本发明通过取异腈类化合物和酰肼类化合物混合，加入有机溶剂，溶解后加入二硫化碳，搅拌反应，制得酰胺基异硫氰酸酯类化合物；取异腈类化合物、胺类化合物混合，加入有机溶剂，溶解后加入二硫化碳，第一次搅拌反应；再加入酰肼类化合物，第二次搅拌反应，制得酰胺基硫脲类化合物。本发明所用单体均为工业原料，成本低，还可进行大规模克级生产；反应操作简单，效率高，单体适用性广泛，在室温和空气的条件下就可进行，且无有毒有害副产物产生；推动酰胺基异硫氰酸酯及酰胺基硫脲类化合物的进一步发展。

一种孵育菜籽粕内源黑芥子酶水解硫代葡萄糖苷方法

本发明涉及一种孵育菜籽粕内源黑芥子酶水解硫代葡萄糖苷的方法，属于农产品加工技术领域。其特征在于，以低温压榨和萃取油脂后的菜籽粕为原料，将菜籽粕粉碎过筛后，在合适的孵育条件下激活其内源黑芥子酶，从而水解硫苷形成异硫氰酸酯等产物，然后通过热处理除去硫苷降解产物。水解产物异硫氰酸酯等功能性降解产物挥发后经冷凝收集，可作为药用和功能食品因子用于医药和食品加工业。本发明中菜籽粕的硫苷降解率达到70％～90％，可用于动物饲料或食品加工原料，从而提高了菜籽粕利用率，减少食品资源浪费，实现菜籽饼粕的综合利用。

一种孵育菜籽粕内源黑芥子酶水解硫代葡萄糖苷方法

本发明涉及一种孵育菜籽粕内源黑芥子酶水解硫代葡萄糖苷的方法，属于农产品加工技术领域。其特征在于，以低温压榨和萃取油脂后的菜籽粕为原料，将菜籽粕粉碎过筛后，在合适的孵育条件下激活其内源黑芥子酶，从而水解硫苷形成异硫氰酸酯等产物，然后通过热处理除去硫苷降解产物。水解产物异硫氰酸酯等功能性降解产物挥发后经冷凝收集，可作为药用和功能食品因子用于医药和食品加工业。本发明中菜籽粕的硫苷降解率达到70％～90％，可用于动物饲料或食品加工原料，从而提高了菜籽粕利用率，减少食品资源浪费，实现菜籽饼粕的综合利用。

一种活性基团及其制备方法、用途

本发明涉及一种全新的活性基团磺酰基异硫氰酸酯即：‑SO 2 NCS把磺酰基异硫氰酸酯基团(‑SO 2 NCS)引入到活性染料领域，通过化学反应合成的染料中间体如以下通式(I)所示，但不仅限于下面所示的通式(I)，

Improvements in or relating to manufacture of thiourea

In a method for producing thiourea by thermal conversion of ammonium thiocyanate, for example as described in Specification 400,916, in which unchanged ammonium thiocyanate is recovered in aqueous solution containing impurities consisting of thiourea and by-products of the conversion, the solution is acidified, for example with sulphuric acid, and treated to separate thiocyanic acid, which may be neutrailzed with ammonia and the resulting pure thiocyanate recycled to the heating step, thus avoiding the cyclic build-up of impurities in the system. If desired, part of the thiocyanate may be separated by crystallization before acidification. The acidified liquid is extracted with a water-immiscible selective solvent for thiocyanic acid, such as ether, cyclohexane, acetophenone, ethyl acetate, or isoamylalcohol. Upon neutralization of the extract with aqueous ammonia, the thiocyanate formed passes into the aqueous phase, whence it is recovered by crystallization, for recycling to the heating step. The solvent is recycled to the <PICT:0645702/IV (b)/1> extraction step. The aqueous phase from the extraction of the acidified liquid is evaporated whereupon ammonium sulphate crystallizes out, the mother liquor still containing a fractional concentration of thiourea and guanidine thiocyanate. The former is extracted with ethyl acetate and, by addition of aqueous ammonia and ammonium nitrate to the aqueous phase, guanidine nitrate is recovered. Specification 645,701 also is referred to.ALSO:<PICT:0645702/III/1> In a method for producing thiourea by thermal conversion of ammonium thiocyanate, such for example as described in Specification 400,916, in which unchanged ammonium thiocyanate is recovered in aqueous solution containing impurities consisting of thiourea and by products of the conversion, the solution is acidified for example by sulphuric acid which, on the addition of a water miscible selective solvent for thiocyanic acid such as ether, cyclohexane, ...

一种活性基团及其制备方法、用途

本发明涉及一种全新的活性基团磺酰基异硫氰酸酯即：‑SO 2 NCS把磺酰基异硫氰酸酯基团(‑SO 2 NCS)引入到活性染料领域，通过化学反应合成的染料中间体如以下通式(I)所示，但不仅限于下面所示的通式(I)，