СПОСОБ ПОЛУЧЕНИЯ ПРОСТОГО ЭФИРА

Изобретение относится к новому способу получения простых эфиров, которые используются в качестве растворителей, смазочных масел, клеящих веществ, смол и т. п. Получение простого эфира общей формулы (XV) или общей формулы (XVI), где R33 и R34 каждый является метильной, этильной, н-пропильной, или изопропильной группой, или углеводородной группой, содержащей атомы эфирного кислорода в основной, в боковой или в той и другой цепях, и могут быть одинаковыми или отличающимися друг от друга, а также R35, R36 и R37 каждый - атом водорода, метильная, этильная, н-пропильная, или изопропильная группа, или углеводородная группа, содержащая атомы эфирного кислорода в основной, в боковой или в той и другой цепях, и могут быть одинаковыми или отличающимися друг от друга, заключается во взаимодействии ацеталя или кеталя общей формулы (XIV) с водородом в присутствии катализатора. При этом катализатор выбирается из сочетания катализатора гидрирования и твердого кислотного катализатора или твердого кислотного ...

ПРОИЗВОДНЫЕ 1-БЕНЗОКСЕПИНА С ФУНГИЦИДНОЙ АКТИВНОСТЬЮ

... 1. Соединения общей формулы (Ia) или (Ib): в которой Y выбирают из атома водорода; атома галогена, выбираемого из фтора, хлора, брома и иода; формила; карбоксила; алкоксила с линейной или разветвленной алкильной частью, содержащей 1-6 атомов углерода; циклеалкоксила с циклоалкильной частью, содержащей 3-7 атомов углерода; гидроксиалкила с линейной или разветвленной алкильной частью, включающей 1-6 атомов углерода; нитрогруппы; алкилкарбонила с линейной или разветвленной алкильной частью, включающей 1-6 атомов углерода; циклоалкилкарбонила с циклоалкильной частью, содержащей 3-7 атомов углерода; алкоксикарбонила с линейной или разветвленной алкильной частью, включающей 1-6 атомов углерода; циклоалкоксикарбонила с циклоалкильной частью, содержащей 3-7 атомов углерода; гетероциклилоксикарбонила; алкилкарбонилоксигруппы с линейной или разветвленной алкильной частью, включающей 1-6 атомов углерода; циклоалкилкарбонилоксигруппы с циклоалкильной частью, содержащей 3-7 атомов углерода; радикала ...

Способ получения ацетата 7(Е)-9(Z)додекадиенола

Изобретение относится к эфирам карбоновых кислот, в частности к способу получения ацетата 7(E)-9(Z)-до- декадиенола (АД), применяемого в сельском хозяйстве. Для упрощения процесса производное ноналя формулы (СН2),(0)СНз , обрабатывают безводным CHjOH при 20-25amp;deg;С или этиленгликолем в безводном бензоле при кипячении в присутствии п- толуолсульфокислоты. Полученное соединение общей формулы ()(R20)CH(CH2)CH20-C(0)CH3 , где R, или R,+R2(-CH4-CH2-), бронируют Вг в CHCl, при , затем соединение формулы (R,O)(RjO)- -СН-СНВг-...-(СН j)-CHj-OC(O)СНз, где R,, R, указаны вьппе, обрабатывают последовательно метилатом Na в диметилсульфоксиде при п-то- луолсульфокислотой в ацетоне при низшим алкилтрифенилфосфоний- иодидом в бензоле в атмосфере азота или аргона при температуре от 20- 25amp;deg;С до кипения или в диметилсуль- фоксиле в присутствии гидрида Na при . Выход АД 32-45% при сокращении числа стадий с 10 до 6. О) со ел О5 QO сл СП ...

Способ получения -кетофосфонатов

Гербицидно-антидотная композиция

Изобретение относитс  к химическим средствам защиты растений ,в частности, к химическим средствам, снижающим фототоксическое действие гербицидов в отношении культурных растений. Цель изобретени  - снижение повреждени  кукурузы тиокарбаматными гербицидами. Согласно изобретению композици  на основе тиокарбаматного гербицида содержит антидот из расчета 0,048-1,66 ч на 1 ч гербицида. В качестве антидота используют соединени  общей формулы R 1 R 2 CXR 3 (YR 4 ), где X-O или N-фенил, N-хлорфенил This invention relates to chemical plant protection products, in particular, to chemical agents that reduce the phototoxic effect of herbicides on cultivated plants. The purpose of the invention is to reduce maize damage by thiocarbamate herbicides. According to the invention, a thiocarbamate herbicide based composition contains an antidote based on 0.048-1.66 hours per 1 hour herbicide. As an antidote, compounds of the general formula R 1 R 2 CXR 3 (YR 4 ) are used, where XO or N-phenyl, N-chlorophenyl Y-O, N-фенил, N-2,6-диметилфенил Y — O, N-phenyl, N-2,6-dimethylphenyl R 1 -водород, дихлорметил, бромметил, хлорметил, трихлорметил R 1 is hydrogen, dichloromethyl, bromomethyl, chloromethyl, trichloromethyl R 2 -водород, дихлорметил R 2 is hydrogen, dichloromethyl R 3 и R 4 каждый C 1 -C 5 , C 8 -C 18 -алкил, аллил, бензил, тетрагидрофурил, фурил, 2-хлорэтил, диметиламиноэтил или R 3 и R 4 вместе бис-метилен, 2-этилэтилен, метилэтил, метилпропилен, гликофурансилен. Ангидоты по изобретению при меньшей дозе обеспечивают равный или более высокий уровень защиты кукурузы от токсического воздействи  тиокарбаматных гербицидов. 5 табл. R 3 and R 4 are each C 1 -C 5 , C 8 -C 18 -alkyl, allyl, benzyl, tetrahydrofuryl, furyl, 2-chloroethyl, dimethylaminoethyl or R 3 and R 4 together bis-methylene, 2-ethylethylene, methylethyl, Methylpropylene, glycofuraniline. Anhydrates according to the invention at a lower dose provide an equal or higher level of protection for maize against the toxic ...

Hemmer der retroviralen Protease

VERFAHREN ZUR HERSTELLUNG VON +VINCADIFFORMIN UND VERWANDTER DERIVATE SOWIE ZWISCHENVERBINDUNGEN

Hydrofluorether mit mindenstens einer hydrierten (-ocfx'ch3)-Endgruppe (x'=f,cf3), Verfahren zur ihrer Herstellung

Substituted diphenyl ethers

Novel substituted diphenyl ethers of the formula in which R<1>, R<2>, R<3>, R<4>, R<5>, Y, m and n have the meaning given in the description, a plurality of processes for the preparation of the novel substances, and their use as herbicides. Novel intermediates and processes for their preparation.

4-TERT.-BUTOXY-BENZLDEHYDDIALKYLACETALE, IHRE HERSTELLUNG UND VERWENDUNG

VERFAHREN ZUR HERSTELLUNG VON ALPHA-HYDROXYCARBONYLVERBINDUNGEN

PROSTAGLANDINS

Prostaglandins

PCT No. PCT/GB82/00348 Sec. 371 Date Aug. 23, 1983 Sec. 102(e) Date Aug. 23, 1983 PCT Filed Dec. 10, 1982 PCT Pub. No. WO83/02273 PCT Pub. Date Jul. 7, 1983.Novel compounds have a formula (I) (I) wherein represents a bicyclo ?2,2,1! hept-2Z-ene, bicyclo ?2,2,1! heptane, 7-oxa-bicyclo ?2,2,1! hept-2Z-ene, 7-oxa-bicyclo ?2,2,1! heptane, bicyclo ?2,2,2! oct-2Z-ene or bicyclo ?2,2,2! octane substituted at the 5-position by the group R1 and at the 6-position by the group ANR2R, a 6,6-dimethyl-bicyclo ?3,1,1! heptane substituted at the 2-position by the group R1 and at the 3-position by the group ANR2R or at the 2-position by the group ANR2R and at the 3-position by the group R1, a cyclohex-1-ene or cyclohexane substituted at the 4-position by the group R1 and at the 5-position by the group ANR2R or a 1-hydroxycyclopentane substituted at the 2-position by the group R1 and at the 2-position by the group ANR2R, R1 is a 6-carboxyhex-2-enyl group or a modification thereof as defined herein; A is ...

CYCLOPENTANE DERIVATIVES

... 1456839 Cyclopenta[b]furan derivatives PFIZER Inc 8 Nov 1973 [8 Nov 1972] 30467/76 Divided out of 1456838 Heading C2C The invention comprises cyclopenta[b]furan derivatives of the formulµ wherein A is 1-adamantyl, 2-norbornyl or 1,2,3,4-tetrahydronaphth-2-yl, or 2-indanyl optionally substituted by one or more halogen atoms, trifluoromethyl, C 1-4 alkyl or C 1-4 alkoxy radicals; Q is p-biphenylylcarbonyl, J is where R is H or C 1-4 alkyl; Q1 is H or p biphenylylcarbonyl, Z s a single or trans-double, bond; Q2 is H or 2-tetrahydropyranyl, Y is oxo and K is with the proviso that when Y is oxo Q2 is 2- tetrahydropyranyl; and their preparation. The compounds of the above formula wherein Y is and Q2 is 2-tetrahydropyranyl are prepared by reducing the corresponding compounds wherein Y is oxo and Q 2 is 2-tetrahydropyranyl, obtained by reacting dihydropyran with the corresponding compounds in which Q1 is H, which are prepared by hydrolysing the corresponding ...

Water-soluble polymer alkanals.

Water-soluble polymer alkanals.

Water-soluble polymer alkanals

Derived from 2,5-dihydrofuranne with triazole group or imidazol, method of preparation, use as fungicide.

Acids and esters of the 5 (2-éventuellement substituted -4-trifluorométhyl-6-phénoxy possibly substituted) - 2-nitro, - carbonyl halation, or-cyano substituted alpha-phényl, oximes and carboxy oximes.

Acids (pyrimidyloxy) phenoxy-alkanecarboxylic, process for their preparation and their use as herbicides.

Fungicides with triazole groups and oligoéther.

Derived from acids phénoxy-phénoxy-alcanoïques and compounds connected, usable in products weedkillers.

Water-soluble polymer alkanals

Water-soluble polymer alkanals

Water-soluble polymer alkanals.

KETONE AND REDUCED KETONE AS THERAPEUTIC MEANS FOR THE TREATMENT OF BONE ILLNESSES

PROCEDURE AND INTERMEDIATE FOR THE PRODUCTION OF RETROVIRALEN PROTEASEHEMMERN

AROMATIC FORMAL ONES AS ADDITIVES FOR THE SINKING OF THE WATER ABSORPTION OF POLYCARBONATES

NEW 1-METHOXY-2-PHENYL-ETHENE FOR the PRODUCTION OF 5-CARBOXALDEHYDE-2-3-DIHYDROBENZOXEPINEN

HERBICIDES MEANS

VERFAHREN ZUR HERSTELLUNG VON VITAMIN K1

HERBIZIDE MITTEL

CYCLIZIERTE SIMILAR ONE OF THE FATTY ACID METABOLITES, PROCEDURES FOR YOUR PRODUCTION AND THESE CONTAINING PHARMACEUTICAL COMPOSITIONS

INHIBITORS THAT RETROVIRALEN PROTEASE

PHENYLETHENYLVERBINDUNGEN WITH RETENOIDÄHNLICHER EFFECT.

OPTICALLY ACTIVE ONES ALPHA-SUBSTITUTED ARYLKETONE, PROCEDURE FOR YOUR PRODUCTION AND YOUR APPLICATION IN THE PRODUCTION OF ALPHA ARYL ALKANE CARBON|UREN.

BENZOCHINON DERIVATIVES AND THEIR PRODUCTION.

SKIN CLARIFICATION COMPOSITIONS

INTERMEDIATE PRODUCTS FOR THE PRODUCTION OF RETROVIRALER PROTEASEHEMMENDEN CONNECTIONS

PROCEDURE FOR the PRODUCTION OF 2,7-DIMETHYL-2,4,6 OCTATRIENAL MONOACETALEN

CYCLOPROPANE COMPOUNDS

A PROCESS FOR PREPARING A NAPHTALENE DERIVATIVE

TERT. BUTYL, TRIFLUOROMETHYL OR TRI-METHYLSILYL PHENYL DERIVATIVES

RETROVIRAL PROTEASE INHIBITING COMPOUNDS

MONOMERS CONTAINING AT LEAST ONE BIARYL UNIT AND POLYMERS AND DERIVATIVES PREPARED THEREFROM

Process for production of benzaldehyde compound

Gem difluorocompounds as depigmenting or lightening agents

The present invention relates to a compound having the formula (I), as well as a method for preparing such a compound, a cosmetic or pharmaceutic composition containing such a compound, and the use thereof as a depigmenting, lightening, bleaching or whitening agent and for treating pigmentation disorders, notably by topical application on the skin.

Process for the preparation of treprostinil

The invention provides a new process for the preparation of treprostinil of formula (I) and its salts using several new intermediates during the building of the ringsystem.

HERBICIDAL COMPOUNDS CONTAINING PHENOXYPHEN-OXYPROPYL DERIVATIVES AND THIO ANALOGUES

Wetting and anti-foaming agent

A wetting agent is disclosed that imparts anti-foam properties to aqueous solutions while reducing surface tension. In one embodiment, a method for defoaming and/or for preventing foaming of liquid media is presented comprising mixing an embodiment of wetting agents described herein, an emulsion thereof, or a powder thereof, with the liquid media.

Wetting and anti-foaming agent

A wetting agent is disclosed that imparts anti-foam properties to aqueous solutions while reducing surface tension. In one embodiment, a method for defoaming and/or for preventing foaming of liquid media is presented comprising mixing an embodiment of wetting agents described herein, an emulsion thereof, or a powder thereof, with the liquid media.

Retroviral protease inhibiting compounds

3-(2-HYDROXY-4-(SUBSTITUTED)PHENYL) CYCLOALKANONE AND CYCLOALKANOL ANALGESIC AGENTS

METABOLITES OF PENTANEDIOIC ACID DERIVATIVES

INTERMEDIATES USEFUL IN THE PREPARATION OF NAPHTHALENE DERIVATIVES

NOVEL DERIVATIVES OF GUANINE

INTERMEDIATE IN THE PREPARATION OF CYCLOPROPYLCARBOXYLATE ESTERS AND PROCESS FOR ITS MANUFACTURE

INTERMEDIATES FOR RETROVIRAL PROTEASE INHIBITING COMPOUNDS

Intermediates and their process of preparation are provided, the intermediates being useful in the preparation of a retroviral protease inhibiting compound of formula (A) (see formula I).

MAMMALIAN METABOLITES OF A TACHYKININ RECEPTOR ANTAGONIST

This invention is concerned with mammalian metabolites of the compound 2-(R)- (1-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4-fluoro)-phenyl-4-(3-(5- oxo-1H,4H-1,2,4-triazolo)methylmorpholine which is a tachykinin receptor antagonist that is useful in the prevention and treatment of certain disorders, including emesis and psychiatric disorders such as depression and anxiety.

INTERMEDIATES IN THE PREPARATION OF CYCLOPROPYLCARBOXYLATE ESTERS AND PROCESS FOR THEIR MANUFACTURE

METHODS FOR PRODUCING CYCLIC BENZAMIDINE DERIVATIVES

Described herein is a method for producing a cyclic benzamidine derivative (C), comprising reacting a fluorinated cyclic benzamidine derivative (A) represented by formula (II), (see formula I)(see formula II) or a salt thereof, with a morpholine-substituted phenacyl derivative (B) represented by formula (VIII), (see formula VIII) or a salt thereof, in the presence of at least one type of solvent selected from a group consisting of ethers and hydrocarbons to obtain a compound represented by formula (XIII), (see formula XIII) or a salt thereof, wherein Hal" represents a halogen atom, Me represents a methyl group; and Et represents an ethyl group). Also disclosed herein is a method for recrystallizing the cyclic benzamidine derivative (C), or a salt thereof, comprising the steps of dissolving compound (C), or the salt thereof, in a mixed solvent comprising either an alcohol and water, or an ether and water, and after dissolution, adding additional water to precipitate crystals of compound ...

PREPARATION OF (ALPHA)-ARYLALKANOIC ACIDS

... 22610 Pharmaceutically useful optically active .alpha.-arylalkanoic acids or esters, ortho esters, or amides thereof are stereoselectively prepared by contacting an aryl magnesium Grignard reagent with an optically active a-substituted acyl halide to form the optically active aryl .alpha.-substituted alkyl ketone, which is ketalized and rearranged to the desired optically active .alpha.-arylalkanoic acid or the corresponding ester, ortho ester or amide. In an alternate embodiment, the aryl .alpha.-substituted alkyl ketone is reduced to the corresponding alkanol, which is rearranged to the .alpha.-arylalkanal. The alkanal so produced is converted to the desired optically active .alpha.-arylalkanoic acid by conventional methods.

OLIGOMERIC FORMAL DIOLS OF COPOLYMER GLYCOLS

TITLE Oligomeric Formal Diols of Copolymer Glycols Oligomeric formal diols are prepared by coupling segments of copolyether glycols with formaldehyde. The formal diols are useful in preparing polyurethanes.

INTERMEDIATE IN THE PREPARATION OF CYCLOPROPYLCARBOXYLATE ESTERS AND PROCESS FOR ITS MANUFACTURE

NOVEL INTERMEDIATE IN THE PREPARATION OF CYCLOPROPYLCARBOXYLATE ESTERS AND PROCESS FOR ITS MANUFACTURE 3-Hydroxymethyl-2,2-dimethylcyclopropanecarbaldehyde dimethyl acetal, especially in the same stereoisomeric form as that of the cyclopropane ring in (+)-3-carene, is a novel intermediate useful in the manufacture of pyrethroid insecticides. It may be manufactured by a process characterised in that 3-acetoxymethyl-2,2-dimethylcyclo-propane carbaldehyde dimethyl acetal is subjected to hydrolysis.

PROSTAGLANDINS

PROSTAGLANDINS Novel compounds have a formula (I) (I) wherein represents a bicyclo ¢2,2,1! hept-2Z-ene, bicyclo ¢2,2,1! heptane, 7-oxa-bicyclo ¢2,2,1! hept-2Z-ene, 7-oxa-bicyclo ¢2,2,1! heptane, bicyclo ¢2,2,2! oct-2Z-ene or bicyclo ¢2,2,2! octane substituted at the 5-position by the group R1 and at the 6-position by the group ANR2R, a 6,6-dimethyl-bicyclo ¢3,1,1! heptane substituted at the 2-position by the group R1 and at the 3-position by the group ANR2R or at the 2-position by the group ANR2R and at the 3-position by the group R1, a cyclohex-1-ene or cyclohexane substituted at the 4-position by the group R1 and at the 5-position by the group ANR2R or a 1-hydroxycyclopentane substituted at the 2-position by the group R1 and at the 2-position by the group ANR2R, R1 is a 6-carboxyhex-2-enyl group or a modification thereof as defined herein; A is an unbranched or branched aliphatic hydrocarbon group with a chain length between the points of attachment to the divalent cyclic ...

PROCESS FOR PREPARING ESTERS OF ALKANOIC ACIDS VIA REARRANGEMENT OF ALPHA-HALOKETALS

Process for preparing esters of alkanoic acids via rearrangement of alpha-haloketals in the presence of a Lewis acid. The reaction is preferably carried out in the presence of catalytic amounts of a Lewis acid and of a diluent at a temperature in the range from about 0.degree. to the reflux temperature of the diluent. The esters thus obtained are useful as intermediate products for preparing drugs. The process involves the preparation of new alpha-haloketals.

CYCLOPENTENEHEPTENOIC ACID DERIVATIVES AND METHOD OF PREPARATION THEREOF

NOVEL ATISANE COMPOUND AND USE THEREOF

A novel compound which is highly effective in ameliorating the cellular disorders caused by radicals and in inhibiting the neurotoxicity induced by excitatory neurotransmitters such as glutamic acid. It is a compound represented by the following formula, a salt thereof, or a hydrate of either. (I) In the formula, Z means an optionally substituted, divalent, C2-3 organic group, etc., and R3 represents carboxyl, etc.

NEW PHENOLIC COMPOUNDS DERIVED FROM DIALKOXYETHANALS, THEIR PREPARATION PROCESS AND THEIR APPLICATION

... 1. New phenolic compounds of formula (I) (see formula I) - R = C3-C17 dialkoxymethyl group, 1,3-dioxolan-2-yl group optionally substituted on peaks 4 and/or 5 by one or more C1-C8 alkyls or 1,3-dioxan- 2-yl group optionally substituted on peaks 4 and/or 5 and/or 6 by one or more C1-C8 alkyls. - n = 1, 2 or 3, the group or groups (see formula II) are in o and/or p position of the OH of the cycle m = from 0 to 4-n, X = functional group such as OH or Hal or C1-C8 alkyl or alkoxy group or C5-C12 aryl group and optionally 1 or 2 heteroatoms such as N or O, or carboxy or-CO-Y group where Y = C1-C8 alkyl or alkoxy or amido or amino or thiol group, on condition that at least one of the ortho or para positions of the phenolic cycle is substituted by a hydrogen, and their salts with the alkali metals, alkaline-earth metals and amines.

NEW 1-METHOXY-2-PHENYL ETHENES FOR THE PREPARATION OF 5-CARBOXALDEHYDE-2-3-DIHYDROBENZOXEPINES

PROCESS FOR PREPARING ESTERS OF ALKANOIC ACIDS VIA REARRANGEMENT OF ALPHA-HALOKETALS

NOVEL ATISANE COMPOUNDS AND USE THEREOF

The present invention provides a novel compound exhibiting an excellent suppressing effect to cell injury caused by radicals and neurotoxicity induced by excitatory nuerotransmitters such as glutamate. Specifically, it provides a compound represented by the following formula, a salt thereof or a hydrate of them. (see formula I) Wherein Z represents a bivalent organic group and the like of from 2 to 3 carbon atom(s) which may have a substituent; and R3 represents a carboxyl group and the like.

PROCESS FOR PREPARATION OF ROFLUMILAST

The present invention provides novel processes for the preparation of N-substituted benzamides having the formula (VIc). In some embodiments, the invention provides a process for preparation of roflumilast and other pharmaceutically active species. Novel compounds, including intermediates for the synthesis of roflumilast, are also provided.

CHIRAL COMPOUNDS, COMPOSITIONS, PRODUCTS AND METHODS EMPLOYING SAME

Compounds that function, alone or in combination, as inhibitors of pigmentation for the improvement of mammalian skin are described herein. Specifically, the compounds of the present disclosure, namely chiral, non-racemic compounds, function as pigment formation inhibitors thereof to beautify skin and discourage the production of melanins. One or more products, consumer and otherwise, comprising the chiral, non-racemic compounds are disclosed herein. Methods of employing both the compounds of the present disclosure and the products incorporating the present compounds are also disclosed herein.

METHOD OF PREPARATION OF PILOCARPINES AND INTERMEDIATES THEREOF

... 2101445 9214693 PCTABS00015 Synthesis of (+)-pilocarpine is achieved via homochiral monoprotected propane-1,3-diols prepared in > 98 % e.e. by enzyme catalyzed acylation of the corresponding diol, and lactones derived therefrom, or via acetylenic alcohols which upon imidazolisation and catalysed carbonylation are converted to lactones again leading to pilocarpine and analogues thereof.

AROMATIC VINYL ETHER COMPOUNDS AND COMPOSITIONS, AND METHOD OF MAKING THE SAME

... 41 An aromatic vinyl ether of the formula: wherein: R1, R2, R4, R5, R6, R8, R9, and R10 are independently selected from hydrogen, halogen, and C1-C8 alkyl radicals; R3 and R7 are independently selected from C1-C8 alkylene radicals; and R11 and R12 are independently selected from allyl and methallyl. Also disclosed are various other aromatic vinyl ether compounds, chain-extended derivatives thereof, and liquid vinyl ether blends, and a method of making the aromatic vinyl ether compounds at high yield. The aromatic vinyl ether compounds, chain-extended vinyl derivatives, and/or liquid vinyl ether blends of the invention may be employed as vinyl ether components together with cationic photoinitiators, to provide cationically polymerizable vinyl ether compositions having utility in applications such as coatings, adhesives, and sealants. #527a/klem2.pct ...

PROCESS OF MAKING (3H) LABELLED PAF PREPARATIONS

TITLE OF THE INVENTION PROCESS OF MAKING ¢3H!-LABELLED PAF PREPARATIONS Disclosed is a process for making ¢3H!-labelled-C15-18PAF (Platelet Activating Factor). ¢3H!-labelled-PAF is useful in numerous biomedical and biochemical assays such as the evaluation and comparison of known PAF antagonists and is exemplified by the following formula: I wherein m and n are positive integers and the sum of n + m is from 12 to 15.

Acetylenic Biaromatic Compounds Containing an Adamantyl Group; Pharmaceutical and Cosmetic Compositions Containing Them and Uses Thereof

HERBIZID WIRKSAMES CHLORALDERIVATPRAEPARAT.

Procédé pour l'obtention d'acétals mixtes

Omega-norprostaglandins - having prostaglandin like action but having longer lasting and more specific action than PGA, PGE, and PGF

Cpds. (I) (where A is 3 - 10 C cycloalkyl, 1 adamantyl, 2 - norbornyl, 2 -(1,2,3,4 - tetrahydronaphthyl), 2 indanyl opt. substd. by halogen, CF3, alkyl, alkoxy, R is H or alkyl, n is 0 - 5, W is single or c is - double bond; Z is single or trans double bond, M is =O, H or OH N + L is a bond, N is alpha-OH when L is H; X is COOR', (R' is H or 1-10 C alkyl, 7 - 9C aralkyl, 3-8C cycloalkyl, alpha or beta-naphthyl 5-indanyl phenyl opt. substd. by halogen, alkyl, alkoxy or phenyl) 5 - tetra azolyl or CONR" (where R" is 2 -10 C alkanoyl, 4 - 8 C - cyclo alkanoyl, 7-11C - aroyl opt. substd. by Me, halogen or MeO, 1 - 7 C alkyl sulphonyl, aryl sulphonyl opt. substd. by Me, halogen or MeO); LM & N being chosen so as to form a cpd. derived from PGA. PGE or PGF) are prepd. from A (CH2)n COOMe by a series of known reactions. Intermediates are also claimed.

Herbicide

WITH IMPROVED HERBICIDAL COMPOUNDS AND COMPOSITIONS AND THEIR PREPARATION METHOD.

INSECT ATTRACTING MEANS TO THE CREATION OF TRACES.

CYCLOALKANOLS CYCLOALKANONES AND SUBSTITUTED IN POSITION 3 BY A GROUP 2-HYDROXYPHENYL SUBSTITUTED IN POSITION 4 AND PHARMACEUTICAL COMPOSITION CONTAINING THEM.

2-(2-Hydroxymethyl-3,3-dimethylcyclopropyl)ethanal dimethyl acetal and process for its preparation

INSATIATED ALCOHOLS AND YOUR USE FOR THE PRODUCTION OF OXOLAN ALCOHOLS AND - AETHERN.

HYDROXY ACETAL ETHYLENIC COPOLYMERS AND THEIR PREPARATION.

CYCLOPROPANCARBONSAEUREESTERDERIVATE.

SPIROCYCLI CONNECTIONS, PROCEDURES FOR THEIR PRODUCTION AND THESE CONTAINING PHARMACEUTICAL PREPARATIONS.

ПРОМЕЖУТОЧНЫЕ СОЕДИНЕНИЯ ДЛЯ ПОЛУЧЕНИЯ ПРОИЗВОДНЫХ ФЕНОКСИУКСУСНОЙ КИСЛОТЫ И СПОСОБ ИХ ИСПОЛЬЗОВАНИЯ

Настоящее изобретение предлагает новые промежуточные продукты, представленные общей формулой (I) и так далее, предназначенные для получения производного феноксиуксусной кислоты, представленного общей формулой (X) или его фармацевтически приемлемой соли, которое обладает β3-адренорецептор-стимулирующей активностью и является пригодным для лечения или профилактики ожирения, гипергликемии, заболеваний, вызванных кишечной гиперкинезией, поллакиурии, недержания мочи, депрессии или желчного конкремента. Настоящее изобретение предлагает также способ получения указанных промежуточных продуктов и способ использования указанных промежуточных продуктов.

ПРОМІЖНІ СПОЛУКИ ДЛЯ ОТРИМАННЯ ПОХІДНИХ ФЕНОКСІОЦТОВОЇ КИСЛОТИ І СПОСІБ ЇХ ОДЕРЖАННЯ

Даний винахід пропонує нові проміжні продукти, представлені загальною формулою (І) і так далі, призначені для отримання похідного феноксіоцтової кислоти, представленого загальною формулою (X), або його фармацевтично прийнятної солі, які мають -адренорецепторстимулюючу активність і є придатними для лікування або профілактики ожиріння, гіперглікемії, захворювань, викликаних кишковою гіперкінезією, полакіурії, нетримання сечі, депресії або жовчного конкремента. Даний винахід пропонує також спосіб отримання вказаних проміжних продуктів і спосіб використання зазначених проміжних продуктів.

Dérivés de cyclopropane et application de certains de ces dérivés comme pesticide.

DERIVES DE CYCLOPROPANE. DERIVES DE CYCLOPROPANE DE FORMULE: (CF DESSIN DANS BOPI) DANS LAQUELLE R REPRESENTE UN GROUPE ACETYLE OU ACETOXY; UN GROUPE ALCOXY CONTENANT DE 2 A 10ATOMES DE CARBONE EVENTUELLEMENT SUBSTITUE PAR UN OU PLUSIEURS ATOMES D'HALOGENE; UN GROUPE (CYCLOALCOYL)ALCOXY CONTENANT DE 3 A 7ATOMES DE CARBONE DANS LE CYCLE; UN GROUPE ALCENYLOXY CONTENANT DE 2 A 4ATOMES DE CARBONE EVENTUELLEMENT SUBSTITUE PAR UN OU PLUSIEURS ATOMES D'HALOGENES; UN GROUPE ALCYNYLOXY CONTENANT DE 2 A 4ATOMES DE CARBONE; UN GROUPE ARYLOXY CONTENANT DE 6 A 12ATOMES DE CARBONE; UN GROUPE ARALCOYLOXY CONTENANT DE 7 A 10ATOMES DE CARBONE; ET X EST -CHCH(OCH); -CHCHO; -CHCHOR OU R EST UN GROUPE ACYLE CONTENANT DE 2 A 5ATOMES DE CARBONE; -CHO; -COCL; -COBR; COOR OU R REPRESENTE UN ATOME D'HYDROGENE, UN CATION FORMANT DES SELS, UN GROUPE ALCOYLE CONTENANT DE 1 A 20ATOMES DE CARBONE; OU UN GROUPE PHENOXYBENZYLE OU ALPHACYANO-PHENOXY-BENZYLE; AVEC LA CONDITION QUE QUAND R EST UN GROUPE ACETOXY, X NE DOIT ...

Synthetic lubricant

Process for the preparation of not-saturated cyclic ketones

Novel cyclised analogs of fatty acid metabolites, process for their preparation and pharmaceutical compositions containing them.

DERIVED FROM 2,3-DIHYDROFURANNE, THEIR METHOD OF PREPARATION, THEIR USE AS INTERMEDIARY FOR the PREPARATION OF TETRAHYDROFURANNE

L'INVENTION CONCERNE DES DERIVES DE 2,3-DIHYDROFURANNE DE FORMULE : (CF DESSIN DANS BOPI) X EST UN ATOME D'HALOGENE, DE PREFERENCE LE FLUOR, LE BROME OU LE CHLORE, OU UN GROUPE ALKYLE OU ALKOXY AYANT DE 1 A 12 ATOMES DE CARBONE, DE PREFERENCE DE 1 A 4 ATOMES DE CARBONE, ET ETANT EVENTUELLEMENT MONO OU POLYHALOGENE (GROUPEMENT CF NOTAMMENT), OU UN GROUPE CYANO DANS LE CAS OU R ETOU R CORRESPONDENT A L'ATOME D'HYDROGENE; N EST UN NOMBRE ENTIER, POSITIF OU NUL, INFERIEUR A 6, DE PREFERENCE EGAL A 2, ETANT ENTENDU QUE LORSQUE N EST SUPERIEUR A 1, LES SUBSTITUANTS X PEUVENT ETRE SOIT IDENTIQUES, SOIT DIFFERENTS; M 0 OU 1; Y CORRESPOND A UN ATOME OU GROUPEMENT SUSCEPTIBLE D'ETRE ELIMINE AU MOYEN D'UNE SUBSTITUTION NUCLEOPHILE, EVENTUELLEMENT APRES TRANSFORMATION INTERMEDIAIRE APPROPRIEE. UTILISATION DE CES DERIVES COMME INTERMEDIAIRES DANS LE PROCEDE DE PREPARATION DE TETRAHYDROFURANNE A GROUPE TRIAZOLE UTILES COMME FONGICIDES. THE INVENTION CONCERNS 2,3-DIHYDROFURAN DERIVATIVES OF FORMULA: (CF DRAWING IN BOPI) X IS A HALOGEN ATOM, PREFERREDLY FLUOR, BROMINE OR CHLORINE, OR AN ALKYL OR ALKOXY GROUP HAVING 1 A 12 CARBON ATOMS, PREFERRED FROM 1 TO 4 CARBON ATOMS, AND POSSIBLY SINGLE OR POLYHALOGENIC (CF GROUPING IN PARTICULAR), OR A CYANO GROUP IN THE CASE WHERE R ETOU R CORRESPOND TO THE HYDROGEN ATOM; N IS AN INTEGER, POSITIVE OR NULL, LESS THAN 6, PREFERREDLY EQUAL TO 2, WHEREAS WHEN N IS GREATER THAN 1, THE SUBSTITUTES X MAY EITHER BE IDENTICAL, OR DIFFERENT; M 0 OR 1; CORRESPONDS TO AN ATOM OR GROUPING LIKELY TO BE ELIMINATED BY MEANS OF A NUCLEOPHILIC SUBSTITUTION, POSSIBLY AFTER APPROPRIATE INTERMEDIATE TRANSFORMATION. USE OF THESE DERIVATIVES AS INTERMEDIARIES IN THE PROCESS FOR THE PREPARATION OF TRIAZOLE GROUP TETRAHYDROFURAN, USEFUL AS FUNGICIDES.

SIMPLE OXIDATIVE FUNCTIONALIZED OF ALKYL ARYL KETONES

The present invention refers to a process for reacting an alkyl aryl ketone obtaining thereby the corresponding aryl oxirane or α-functionalized alkyl aryl ketal, the aryl oxirane or α-functionalized alkyl aryl ketal obtained by the process as well as the α-functionalized ketone obtained by the process. 2: The process according to claim 1 , wherein Rand Rare the same.3: The process according to claim 2 , wherein Rand Rare selected from H and linear or branched C-C-alkyl.4: The process according to claim 1 , wherein Rand Rare different and are independently selected from H and linear or branched C-C-alkyl.5: The process according to claim 1 , wherein Rand Rform a C-C-cycloalkyl together with the connecting C atom.6: The process according to claim 1 , wherein R claim 1 , R claim 1 , R claim 1 , Rand Rare the same.7: The process according to claim 6 , wherein R claim 6 , R claim 6 , R claim 6 , Rand Rare selected from H and linear or branched C-C-alkyl.8: The process according to claim 1 , wherein R claim 1 , R claim 1 , R claim 1 , Rand Rare different and at least one of them is selected from linear or branched C-C-alkyl claim 1 , linear or branched C-C-alkenyl claim 1 , C-C-alkoxy claim 1 , C-C-alkenyloxy claim 1 , C-C-alkenylarylalkoxy or N(R)or SR claim 1 , wherein Ris selected from linear or branched C-C-alkyl or linear or branched C-C-alkenyl or Rform a C-C-alicyclic system together with the connecting N atom.9: The process according to claim 1 , wherein one of R claim 1 , R claim 1 , R claim 1 , Rand Ris linear or branched C-C-alkenyl C-C-alkenyloxy claim 1 , C-C-alkenylarylalkoxy claim 1 , or N(R)or SRwith Rbeing selected from linear or branched C-C-alkyl or linear or branched C-C-alkenyl or Rform a C-C-alicyclic system together with the connecting N atom; and the remaining ones are independently selected from H and linear or branched C-C-alkyl.10: The process according to claim 1 , wherein two or three of R claim 1 , R claim 1 , R claim 1 , Rand Rare linear or ...

COMPOSITION AND METHOD FOR MANUFACTURING DEVICE USING SAME

An onium salt and a composition having high sensitivity and excellent pattern characteristics such as LWR, which is preferably used for a resist composition for a lithography process using two active energy rays of a first active energy ray such as an electron beam or an extreme ultraviolet and a second active energy ray such as UV. 2. The onium salt of claim 1 , wherein the onium salt is represented by any one selected from the general formula (11) and the general formula (12).4. A photoacid generator comprising at least the onium salt of .5. A composition comprising: the photoacid generator of ; and an acid reactive compound.6. The composition of claim 5 , further comprising an acid-diffusion controller.10. A method of manufacturing a device claim 5 , comprising:{'claim-ref': {'@idref': 'CLM-00005', 'claim 5'}, 'forming a resist film by applying the composition of to a substrate;'}irradiating the resist film with a first active energy ray;irradiating a resist film after irradiating with the first active energy ray, with a second active energy ray; andobtaining a pattern by developing a resist film after irradiating with the second active energy ray.11. The method of claim 10 , wherein a wavelength of the first active energy ray is shorter than a wavelength of the second active energy ray.12. The method of claim 11 , wherein the first active energy ray is an electron beam or an extreme ultraviolet.13. The method of claim 10 , further comprising heating with a heating wire or a laser between irradiating with the first active energy ray and irradiating with the second active energy ray.14. The method of claim 10 , wherein:generating a first active species from the composition in the resist film by irradiating with the first active energy ray;changing a structure of the photoacid generator by the first active species; andgenerating a second active species from a structure-changed photoacid generator by irradiating with the second active energy ray.15. The method of ...

MODULATORS OF KV3 CHANNELS TO TREAT PAIN

The present invention provides a modulator of Kv3.1 and/or Kv3.2 and/or Kv3.3 channels for use in the prophylaxis or treatment of pain. Modulators for use in the prophylaxis or treatment of pain include compounds of formula (I) or a pharmaceutically acceptable salt and/or solvate thereof and/or derivative thereof: 1. A method of treating hypersensitivity in a subject with neuropathic pain by administering a modulator of Kv3.1 and/or Kv3.2 and/or Kv3.3.2. The method of wherein the modulator of Kv3.1 and/or Kv3.2 and/or Kv3.3 is capable of producing at least 20% potentiation of whole-cell currents mediated by human Kv3.1 and/or Kv3.2 and/or Kv3.3 channels recombinantly expressed in mammalian cells.3. The method of wherein the neuropathic pain is central neuropathic pain.4. The method of wherein the neuropathic pain is peripheral neuropathic pain.5. The method of wherein the hypersensitivity is hyperalgesia.6. The method of wherein the hypersensitivity is allodynia.7. The method of wherein the neuropathic pain is selected from the group consisting of diabetic neuropathy claim 1 , post-herpetic neuralgia claim 1 , spinal cord injury pain claim 1 , phantom limb (post-amputation) pain claim 1 , and post-stroke central pain.8. The method of wherein the neuropathic pain is due to trauma claim 1 , chemotherapy or heavy metal exposure.12. A method of treating neuropathic pain in a subject by administering a modulator of Kv3.1 and/or Kv3.2 and/or Kv3.3 claim 1 , wherein treating neuropathic pain does not include the treatment of a sleep disorder due to neuropathic pain.13. The method of wherein the modulator of Kv3.1 and/or Kv3.2 and/or Kv3.3 is capable of producing at least 20% potentiation of whole-cell currents mediated by human Kv3.1 and/or Kv3.2 and/or Kv3.3 channels recombinantly expressed in mammalian cells.14. The method of wherein the neuropathic pain is central neuropathic pain.15. The method of wherein the neuropathic pain is peripheral neuropathic pain.16. The ...

PERFLUOROPOLYVINYL MODIFIED ARYL MONOMERS

A compound of formula (I) 2. A compound of claim 1 , wherein Ris —CF.3. A compound of claim 1 , wherein Ris —CF.4. A compound of claim 1 , wherein Ris —CFCFXCFand X is —F.5. A compound of claim 1 , wherein Ris —CFCFXCFand X is —OCF.6. A compound of claim 1 , wherein Ris —CF.7. A compound of claim 1 , wherein Ris —CF.8. A compound of claim 1 , wherein Ris —CFCFXCFand X is —F.9. A compound of claim 1 , wherein Ris —CFCFXCFand X is —OCF.10. A compound of claim 1 , where Ris —(CH)— and q is 1 to 10.11. A compound of claim 1 , where Ris —(OCHCH)1 to 10.12. A compound of claim 1 , where Ris —(CH)(OCHCH)— and q is 1 to 10 and t is 1 to 10.13. A compound of claim 1 , wherein Y is H.14. A compound of claim 1 , wherein Y is Cl.15. A compound of claim 1 , wherein Y is Br.16. A compound of claim 1 , wherein Yis H.17. A compound of claim 1 , wherein Yis Cl.18. A compound of claim 1 , wherein Yis Br.19. A compound of claim 1 , where Rand Rare the same.20. A compound of claim 1 , where Y and Yare the same. The present invention comprises aryl compounds having at least two partially fluorinated pendent groups which can be useful as additives for fluorinated oils and greases or as fluorinated solvents.Fluorinated oil additives are generally produced from alcohols to which are expensive and are prepared through several step synthesis. These alcohols are either then reacted to make additives or solvents. New starting materials are needed that do not utilize linear perfluorinated alcohols.U.S. Pat. No. 7,531,700 teaches fluorinated solvents having benzene is rings with a) perfluorinated pendent alkyl groups, b) alkyl, alkoxy, or oxyalkyl groups and c) optionally halogen pendent groups useful for the manufacture of organic electronic devices. These solvents are non-reactive.Patent Application WO 20071149449 teaches fluoroalkoxystyrenes prepared by contacting fluorinated olefin with a solution of hydroxystyrene. These fluoroalkoxystyrenes are useful in resins, elastomers, polymers, or ...

Wetting and anti-foaming agent

A wetting agent according to Formula (I): wherein R 1 is selected from a branched alkyl group or linear alkyl group or a cycloaliphatic group or an aromatic group, each having 6 to 15 carbon atoms; R 2 is selected from hydrogen, methyl, or ethyl; R 3 is selected from hydrogen, methyl, or ethyl; R 4 is selected from hydrogen, methyl, or ethyl; R 5 is selected from methyl or ethyl; x ranges from 0 to 5; y ranges from 0 to 10; z ranges from 1 to 10; with the proviso that when x ranges from 1 to 5, R 2 is different from R 3 ; and with the proviso that when x=0, R 3 is different from R 4 . The wetting agent also imparts anti-foam properties to aqueous solutions while reducing surface tension.

USES FOR AN ACETAL BASED COMPOSITION AND METHOD OF THINNING/CLEANING/STRIPPING

An acetal-based composition is described which includes an acetal of formula R—O—CH—O—R′. R and R′ are mutually independent alkyl or alkoxyalkyl substituents with at least three carbon atoms. The composition is useful as a thinner and/or a detergent and/or a stripper. The composition may be used to clean surfaces which are metal, glass or wood and is particularly well adapted for use in the automotive industry. The thinning/cleaning/stripping composition may be stored in a polyethylene container. 1. A composition for use as a as thinner and/or detergent and/or stripper comprising an acetal of formula R—O—CH—O—R′ , whereby R and R′ are mutually independent an alkyl or alkoxyalkyl substituent with at least three carbon atoms.2. The composition according to claim 1 , whereby the acetal is CH—O—(CH)—O—CH—O—(CH)—O—CH.3. The composition according to claim 1 , wherein the composition comprises 50%-100% by weight of the acetal claim 1 , expressed with respect to the total weight of the composition.4. The composition of which is substantially water and/or acid-free claim 1 , more specifically with a content lower than 5% by weight.5. Method for the cleaning and/or stripping of a metal surface at least partially covered with a residue claim 1 , comprising the steps of:{'claim-ref': {'@idref': 'CLM-00001', 'claim 1'}, 'applying the composition of , on the metal surface to clean, and'}removing the residue.6. Method according to claim 5 , wherein the composition is applied with a high pressure cleaning device.7. Method according to claim 5 , further comprising the step of: separating residue and acetal.8. Method according to claim 5 , wherein the acetal applied and the metal surface to clean are in contact during 10 s to 60 min.9. Method according to claim 5 , wherein the cleaning is performed at a temperature of 20° C.-30° C.10. Method according to claim 5 , further comprising the steps of:post-rinsing of the cleaned surface with water, anddrying of the rinsed surface.11. ...

Synthetic Route To Anhydroryanodol, Ryanodol And Structural Analogues

This disclosure is related to methods for producing anhydroryanodol, ryanodol, or analogues thereof and novel compounds prepared thereby. This application is a divisional of U.S. patent application Ser. No. 15/381,595, filed Dec. 16, 2016, which claims the priority of U.S. Provisional Patent Application No. 62/269,760, filed Dec. 18, 2015, both applications of which are incorporated by reference.This invention was made with government support under Grant No. DGE1144469 awarded by the National Science Foundation and Grant RGM097582-01 awarded by the national Institute of General Medical Sciences. The government has certain rights in invention.This disclosure is related to methods for producing anhydroryanodol, ryanodol, and analogues thereof.Terpenes are a large and structurally diverse family of natural products that range from simple hydrocarbons associated with flavors and fragrances, to complex, highly oxidized polycyclic molecules such as the anti-malarial drug artemisinin, and the anticancer compounds ingenol and taxol. Although terpenes are isolated from natural sources, it can be challenging to translate their biological activity into a practical application. In some cases, the hurdle is low natural abundance; other times, it is the difficulty encountered by chemists seeking to precisely edit a terpene's molecular structure in order to improve its drug-like properties or interrogate its role in modulating disease pathways. The development of concise chemical syntheses of terpenes can transform the ability to use these molecules and their synthetic derivatives as biological probes or as lead compounds for the development of new medicines. Furthermore, these scientific efforts often innovate chemical reactivity or synthetic design concepts.The natural product ryanodine (1) and its hydrolysis product ryanodol (2) are among the most highly oxidized and synthetically challenging diterpenoids reported to date.Isolated from the tropical shrub Ryania speciosa Vahl in ...

CANNABINOID DERIVATIVES

The present invention provides cannabinoid derivatives, a pharmaceutical composition comprising said derivative and a method of using said derivatives in treating or preventing a disease associated with cannabinoid receptors. The claimed cannabinoid derivatives are described by formula (I) or an enantiomer, diastereomer, racemate, tautomer, or metabolite thereof, or a pharmaceutically acceptable salt, solvate or hydrate of the compound. 1131-. (canceled)134. The compound according to claim 132 , wherein Ris hydrogen claim 132 , an unsubstituted C-Calkyl claim 132 , or a substituted or unsubstituted C-Calkenyl.135. The compound according to claim 132 , wherein Ris hydrogen claim 132 , C-Calkyl claim 132 , hydroxy claim 132 , —CHOH claim 132 , —COH claim 132 , —CO(C-Calkyl) claim 132 , or oxo.136. The compound according to claim 132 , wherein Ris C-Calkyl claim 132 , C-Calkenyl claim 132 , C-Calkynyl claim 132 , —(OCHCH)OCH claim 132 , —(C-Calkyl)-aryl claim 132 , —(C-Calkyl)-heteroaryl claim 132 , —(C-Calkyl)-cycloalkyl or —(C-Calkyl)-heterocycloalkyl.137. The compound according to claim 136 , wherein the heterocycloalkyl is azetidinyl and is substituted with 1-2 Rwhich are independently oxo claim 136 , C-Calkyl claim 136 , —Cl claim 136 , —F claim 136 , —Br claim 136 , —C(O)R claim 136 , or —COR claim 136 , wherein Ris H or C-Calkyl.140. The compound according to claim 139 , wherein Qis YR claim 139 , wherein Yis O or S claim 139 , and Ris hydrogen claim 139 , deuterium claim 139 , C-Calkyl claim 139 , —(CHCHO)(C-Calkyl) claim 139 , —C(O)R claim 139 , —COR claim 139 , C-Calkenyl claim 139 , C-Calkynyl claim 139 , —(C-Calkyl)-aryl claim 139 , —(C-Calkyl)-heteroaryl claim 139 , —(C-Calkyl)-cycloalkyl or —(C-Calkyl)-heterocycloalkyl or Qis —NRR claim 139 , wherein Rand Rare independently hydrogen claim 139 , C-Calkyl claim 139 , —(CHCHO)(C-Calkyl) claim 139 , —C(O)R claim 139 , —COR claim 139 , C-Calkenyl claim 139 , C-Calkynyl claim 139 , —(C-Calkyl)-aryl claim 139 , ...

Recyclable and reworkable polyol(s)

Polyol component(s) for a recyclable polyurethane system is disclosed. The recyclable polyurethane system comprises a polyol component having a structural Formula (I), a polyol component having a structural Formula (II) or a polyol component having a structural Formula III and an isocyanate curing agent. A process(es) for preparing the polyol component having the structural Formula (I), the polyol component having the structural Formula (II) and the polyol component having the structural Formula (III) is also disclosed.

Process for the Preparation of a Polysulfide

Pre-polymer according to structure (I) X—(R 2 —O) n —CH 2 (R 1 —O) m —CH 2 —(O—R 2 ) p —X (I) wherein R 1 and R 2 can be the same or different and are selected from alkane chains containing 2-10 carbon atoms, X is a halogen atom, and n, m, and p are integers that can be the same of different and have a value in the range 1-6. The use of this pre-polymer in the preparation of a liquid polysulfide polymer allows better control over the sulfur and oxygen content and the polarity of the resulting polymer.

SURFACTANT COMPOSITIONS AND USE THEREOF

Surfactants capable of releasing and/or dissolving polymers to form water-soluble or water-dispersible polymer solutions are disclosed. In addition, polymer compositions containing a water-in-oil emulsion comprising the surfactant are provided and can be used, for example, in methods of dissolving a polymer. Also disclosed are detergent compositions and methods of cleaning articles and/or membranes using the surfactants herein. These surfactants and polymer compositions can be used in various industries including for water clarification, papermaking, sewage and industrial water treatment, drilling mud stabilizers, and enhanced oil recovery. 34.-. (canceled)7. (canceled)9. The compound of claim 5 , wherein R claim 5 , R claim 5 , R claim 5 , R claim 5 , and Rare independently hydrogen or Cto Calkyl.10. The compound of claim 9 , wherein R claim 9 , R claim 9 , R claim 9 , R claim 9 , and Rare hydrogen.11. The compound of claim 9 , wherein Rand Rare hydrogen.12. The compound of claim 8 , wherein Ris hydrogen or methyl.13. The compound of claim 8 , wherein Ris —(CH)z-O—Rand z is 1 to 3.14. (canceled)15. The compound of claim 13 , wherein Ris Cto Calkyl.16. The compound of claim 15 , wherein X is —O— or —N(R)—.17. The compound of claim 16 , wherein X is —O—.18. The compound of claim 16 , wherein X is —N(R)— and Ris hydrogen.19. (canceled)20. The compound of claim 8 , wherein Z has the structure of moiety A claim 8 , X is —O— claim 8 , n is 0 claim 8 , R claim 8 , R claim 8 , R claim 8 , R claim 8 , Rare hydrogen claim 8 , Rand Rare hydrogen claim 8 , Ris —(CH)z-O—R claim 8 , z is 1 claim 8 , Ris hydrogen claim 8 , Ris 2-ethylhexyl claim 8 , and m is an integer from 7 to 13.21. (canceled)23. The compound of claim 22 , wherein n is 0 claim 22 , Ris —(CH)z-O—R claim 22 , Ris hydrogen claim 22 , Ris 2-ethylhexyl claim 22 , m is an integer from 10 to 30 claim 22 , and z is 1.2527.-. (canceled)28. A polymer composition comprising:{'claim-ref': {'@idref': 'CLM-00001', 'claim 1 ...

METHOD FOR PRODUCING POLYALKYLENE GLYCOL DERIVATIVE WITH NARROW MOLECULAR WEIGHT DISTRIBUTION, AND ACETAL GROUP-CONTAINING ALCOHOL COMPOUND FOR USE THEREIN AND ALKALI METAL SALT THEREOF

A method for producing a narrow molecular weight distribution polyalkylene glycol derivative having an amino group at an end is provided and allows for polymerization of ethylene oxide under mild conditions with suppressed occurrence of diol polymer impurities includes at least the steps of polymerizing ethylene oxide by using a compound represented by the following general formula (2) and converting a polymer end to R: 3. The method according to claim 2 , wherein the organic solvent for use in the step 1) is a single solvent or a mixed solvent selected from the group consisting of cyclic ether compounds having 4 to 10 carbon atoms.4. The method according to claim 2 , wherein the step 1) is performed without an alcohol co-solvent.6. The method according to claim 5 , wherein the reaction is performed so as to have a mass ratio between the compound represented by the general formula (1) and the compound represented by the general formula (2) of 0:100 to 20:80 claim 5 , after completion of the preceding step.7. The method according to claim 5 , further comprising a step of synthesizing a compound represented by the general formula (1) prior to the preceding step.8. A narrow molecular weight distribution polyalkylene glycol derivative having an amino group at an end represented by a general formula (7) produced by the method according to :{'br': None, 'sub': 2', '2', '2', '2', 'n, 'sup': 2', '3, 'HN—CH—R—(OCHCH)—OR\u2003\u2003(7)'}{'sup': '2', 'wherein Rrepresents a linear or branched divalent hydrocarbon group having 1 to 5 carbon atoms;'}{'sup': '3', 'Rrepresents a linear, branched, or cyclic monovalent hydrocarbon group having 1 to 20 carbon atoms; and'}n represents an integer of 1 to 450.11. The method according to claim 3 , wherein the step 1) is performed without an alcohol co-solvent. This application claims priority from Japanese Patent Application No. 2014-006074, filed Jan. 16, 2014, the disclosure of which is incorporated by reference herein in its entirety. ...

DERIVATIVES OF SOBETIROME

Disclosed are halo substituted derivative compounds of sobetirome with improved pharmacological characteristics relative to sobetirome, pharmaceutical compositions that include those compounds and methods of treating diseases such as neurodegenerative disorders using those pharmaceutical compositions. 2. The compound of claim 1 , or a pharmaceutically acceptable salt thereof claim 1 , wherein Rand Rare independently selected from the group consisting of chloro and bromo.3. The compound of claim 1 , or a pharmaceutically acceptable salt thereof claim 1 , wherein Rand Rare both bromo.4. The compound of claim 3 , or a pharmaceutically acceptable salt thereof claim 3 , wherein Ris —OH.5. The compound of claim 3 , or a pharmaceutically acceptable salt thereof claim 3 , wherein Ris —NHRand Ris Calkyl.6. The compound of claim 5 , or a pharmaceutically acceptable salt thereof claim 5 , wherein Ris methyl.7. The compound of claim 1 , or a pharmaceutically acceptable salt thereof claim 1 , wherein Rand Rare both chloro.8. The compound of claim 7 , or a pharmaceutically acceptable salt thereof claim 7 , wherein Ris —OH.9. The compound of claim 7 , or a pharmaceutically acceptable salt thereof claim 7 , wherein Ris —NHRand Ris Calkyl.10. The compound of claim 15 , or a pharmaceutically acceptable salt thereof claim 15 , wherein Ris methyl.11. The compound of claim 1 , or a pharmaceutically acceptable salt thereof claim 1 , for use in treating a neurodegenerative disorder.12. The compound of claim 11 , or a pharmaceutically acceptable salt thereof claim 11 , wherein the neurodegenerative disorder is a demyelinating disease.13. The compound of claim 11 , or a pharmaceutically acceptable salt thereof claim 11 , wherein the neurodegenerative disorder is X-linked adrenoleukodystrophy or multiple sclerosis.14. A pharmaceutical composition comprising a compound of claim 1 , or a pharmaceutically acceptable salt thereof claim 1 , and one or more pharmaceutically acceptable carriers.15. ...

PROCESS FOR THE PREPARATION OF TREPROSTINIL

Treprostinil is a synthetic prostacyclin derivative with thrombocyte aggregation inhibitory and vasodilatory activity. Treprostinil can be administered in subcutaneous, intravenous, inhalable, or oral forms. Disclosed is a method for the preparation of treprostinil of formula I and its amorphous form, anhydrate form, monohydrate form, and polyhydrate form salts with bases. In the disclosed method, the chiral center in the 3-hydroxyoctyl substituent is formed at the end of the synthesis, so that the method is robust and well scalable. 2. Process as defined in for the preparation of the salts of treprostinil of formula I given with bases claim 1 , wherein as polar solvent Copen-chain or branched organic alcohol claim 1 , is applied.3. Process as defined in for the preparation of the salts of treprostinil of formula I given with bases claim 1 , wherein as for base claim 1 , the solventless organic or inorganic base which contains the cation of the desired salt is applied.4. Process as defined in for the preparation of the salts of treprostinil of formula I given with bases claim 3 , wherein as for base claim 3 , an organic or inorganic base containing alkali metal or alkali earth-metal cation is applied.5. Process as defined in for the preparation of the salts of treprostinil of formula I given with bases claim 4 , wherein as for base sodium carbonate monohydrate claim 4 , sodium hydrogen carbonate claim 4 , sodium methylate claim 4 , or sodium carbonate hydrate is applied.6. Process as defined in for the preparation of the salts of treprostinil of formula I given with bases claim 1 , wherein the reaction mixture is agitated in an inert atmosphere until salt formation proceeds.7. Process as defined in for the preparation of the salts of treprostinil of formula I given with bases claim 1 , wherein as the organic solvent of the crystallisation an ether claim 1 , ester claim 1 , or ketone solvent is applied.8. Process as defined in for the preparation of the salts of ...

Low-salt process for the preparation of a polysulfide

wherein R1 and R2 can be the same or different and are selected from alkane chains containing 2-10 carbon atoms, X is a halogen atom, and n, m, and p are integers that can be the same or different and have a value in the range 1-6, with either (i) sodium polysulfide or (ii) a combination of sodium hydrosulfide and sulfur.

METHOD OF PRODUCING ALIPHATIC ALDEHYDE COMPOUND HAVING TERMINAL CONJUGATED DIENE STRUCTURE AND INTERMEDIATE THEREFOR

Provided are a method for producing a terminal conjugated dienal compound without an oxidation reaction and a terminal hydroxyacetal compound useful as an intermediate in the method. More specifically, provided are a method for producing an (E)-dienal compound comprising the steps of: a metalation reaction of an alkynal acetal compound (1) to obtain an organic metal compound (2), an addition reaction of (2) to ethylene oxide to obtain a hydroxyalkynal acetal compound (3), a reduction reaction of (3) to obtain an (E)-hydroxyalkenal acetal compound (4), a functional group conversion reaction of (4) to obtain an (E)-alkenal acetal compound (5) having a leaving group X, an elimination reaction of (5) to obtain an (E)-dienal acetal compound (6), and a hydrolysis reaction of (6) to obtain the (E)-dienal compound (7); and others. 2. The method for producing an (E)-dienal compound according to claim 1 , wherein the (E)-dienal compound is (E)-11 claim 1 ,13-tetradecadienal.4. The method for producing a (Z)-dienal compound according to claim 3 , wherein the (Z)-dienal compound is (Z)-11 claim 3 ,13-tetradecadienal. This application claims priority to Japanese Patent Application No. 2016-083120 filed Apr. 18, 2016; the entire disclosure of the application is incorporated herein by reference.The present invention relates to a method of producing an aliphatic aldehyde compound having a terminal conjugated diene structure, which is, for example, a sex pheromone of insects; and a synthetic intermediate to be used for the method.A sex pheromone of insects is generally a bioactive substance being released by female individuals and having a function of attracting male individuals, and exhibits high attracting activity even in a small amount. The sex pheromone has been used widely as a means for predicting the emergence of insects or finding geological spread thereof (invasion in specific areas) or as a means for pest control. As the means for pest control, a control method called “ ...

WETTING AND ANTI-FOAMING AGENT

A wetting agent according to Formula (I): 114-. (canceled)17. The wetting agent according to claim 15 , wherein Ris selected from a branched alkyl group or linear alkyl group or a cycloaliphatic group or an aromatic group claim 15 , each having 6 to 10 carbon atoms.18. The wetting agent according to claim 17 , where in Ris selected from nonyl claim 17 , isononyl claim 17 , 3 claim 17 ,5 claim 17 ,5-trimethyl hexyl claim 17 , octyl claim 17 , 2-methyl heptyl claim 17 , 2-ethyl hexyl claim 17 , 2 claim 17 ,2 claim 17 ,4-trimethyl pentyl claim 17 , 4-methyl pentyl claim 17 , heptyl claim 17 , hexyl and combinations thereof.19. The wetting agent according to claim 15 , wherein a 0.3 wt. % solution of the wetting agent composition in aqueous solution has a dynamic surface tension ranging from 50 mN/m to 25 mN/m at 1000 ms or less surface age.20. The wetting agent according to claim 15 , wherein a 0.3 wt. % solution of the wetting agent in aqueous solution has a static surface tension ranging from 45 mN/m to 20 mN/m.21. The wetting agent according to claim 15 , wherein a 0.3 wt. % solution of the wetting agent in aqueous solution has a foaming value less than 17 cm when measured at a concentration of 0.3 wt. % according to the foam test procedure and has a foaming value less than 3 cm when measured at a concentration of 0.3 wt. % 5 minutes after completion of the foam test procedure. This application claims priority benefit from U.S. Provisional Patent Application 62/238,260 filed Oct. 7, 2015 which is incorporated by reference herein in its entirety.The present invention relates to use of multifunctional alkoxylate compositions as dual wetting and anti-foaming agents.The ability to reduce the surface tension of water is important for waterborne coating formulations as decreased surface tension leads to enhanced substrate wetting particularly for hydrophobic surfaces. Static- and dynamic surface tension are important measures of the ability of a wetting agent to reduce ...

DERIVATIVES OF SOBETIROME

Disclosed are halo substituted derivative compounds of sobetirome with improved pharmacological characteristics relative to sobetirome, pharmaceutical compositions that include those compounds and methods of treating diseases such as neurodegenerative disorders using those pharmaceutical compositions. 117-. (canceled)19. The method of claim 18 , wherein the neurodegenerative disorder is a demyelinating disease.20. The method of claim 18 , where the neurodegenerative disorder is X-linked adrenoleukodystrophy.22. The unit dosage form of claim 21 , wherein Rand Rare independently chloro or bromo claim 21 , or a pharmaceutically acceptable salt thereof.23. The unit dosage form of claim 21 , wherein Rand Rare both bromo claim 21 , or a pharmaceutically acceptable salt thereof.25. The unit dosage form of claim 24 , wherein the compound is in the form of the free acid.26. The unit dosage form of claim 25 , wherein the unit dosage form is a tablet or capsule.27. The unit dosage form of claim 23 , wherein Ris —NHRand Ris Calkyl claim 23 , or a pharmaceutically acceptable salt thereof.29. The unit dosage form of claim 28 , wherein the compound is in the form of the free base.30. The unit dosage form of claim 29 , wherein the unit dosage form is a tablet or capsule.31. The unit dosage form of claim 21 , wherein Rand Rare both chloro claim 21 , or a pharmaceutically acceptable salt thereof.33. The unit dosage form of claim 32 , wherein the compound is in the form of the free acid.34. The unit dosage form of claim 33 , wherein the unit dosage form is a tablet or capsule.35. The unit dosage form of claim 31 , wherein Ris —NHRand Ris Calkyl claim 31 , or a pharmaceutically acceptable salt thereof.37. The unit dosage form of claim 36 , wherein the compound is in the form of the free base.38. The unit dosage form of claim 37 , wherein the unit dosage form is a tablet or capsule.39. A method of treating a neurodegenerative disorder claim 21 , the method comprising administering to a ...

Agente humectante y antiespumante.

Un agente humectante de acuerdo con la Fórmula (I): (ver Fórmula) en donde R1 se selecciona a partir de un grupo alquilo ramificado o un grupo alquilo lineal o un grupo cicloalifático o un grupo aromático, cada uno tiene de 6 a 15 átomos de carbono; R2 se selecciona a partir de hidrógeno, metilo o etilo; R3 se selecciona a partir de hidrógeno metilo o etilo; R4 se selecciona a partir de hidrógeno, metilo o etilo; R5 se selecciona a partir de metilo o etilo; x varía de 0 a 5; ``y´´ varía de 0 a 10; z varía de 1 a 10; con la condición de que cuando x varía de 1 a 5, R2 es diferente de R3; y con la condición de que cuando x = 0, R3 es diferente de R4. El agente humectante además les proporciona propiedades antiespumantes a soluciones acuosas al reducir su tensión superficial.

플루오로비닐에테르들 및 그것으로부터 얻을 수 있는 중합체

식 CFX=CXOCF 2 OR(여기서 R은 C 2 -C 6 선형, 분지형 또는 C 5 -C 6 시클릭(퍼)플루오로알킬기, 또는 1 - 3 산소원자들을 함유하는 C 2 -C 6 선형, 분지형 (퍼)플루오로옥시알킬기이고; R이 상기 규정된 대로의 플루오로알킬 또는 플루오로옥시알킬기일 때, 그것은 H, Cl, Br, I에서 선택되는 동일하거나 다른 1 내지 2 원자들을 함유할 수 있고; X = F, H)을 갖는 플루오로비닐에테르들; 상기 플루오로비닐에테르들을 적어도 또 하나의 중합가능한 단량체로 중합하여 얻을 수 있는 동중합체 또는 중합체.

Process for the preparation of substituted acyclic nucleosides, and intermediates occurring therein

It is possible, by using symmetrical formaldehyde acetals of the formula ##STR1## in which the substituents R 1 -R 3 have the specified meanings, advantageously to introduce the substituent ##STR2## into nitrogen-containing heterocyclic systems to form acyclic nucleoside analogs.

Preparation and purification of poly(tetramethylene ether) formal glycols and poly(oxybutylene formal) glycols

Oligomeric formal diols are prepared by coupling segments of poly(tetramethylene ether) glycols, each having a molecular weight of 650-3000, with formaldehyde in the presence of a granular acidic catalyst, to yield poly(tetramethylene ether) formal glycols of 1,400-12,000 molecular weight. Oligomeric formal diols of a second type can also be prepared by coupling with formaldehyde segments of poly(tetramethylene ether) glycols mixed with segments of other polymeric glycols, as for example polyethylene oxide glycol of 200 molecular weight, to yield poly(ether formal) glycols of substantially higher molecular weight than either of the starting polyether glycols, and having properties significantly different from the parent polyether glycols that may affect the performance as soft or elastomeric segments of derived polyurethanes, polyetheresters, and polyureas. Yet a third type of oligomeric formal diols can be prepared by coupling monomeric diols, as for example 1,4-butanediol, with formaldehyde to yield higher molecular weight poly(oxybutylene formal) glycols.

Methods for producing cyclic benzamidine derivatives

In the present invention, the methods of producing a fluorinated cyclic benzamidine derivative (A), or a salt thereof, comprise the step of reacting a specific novel compound with ammonia or imide. The methods of this invention for producing a morpholine-substituted phenacyl derivative (B), or a salt thereof, comprise reaction of a specific novel compound with morpholine, reaction of the product with a halogenating reagent, and deketalization of the product. The methods of this invention for a producing cyclic benzamidine derivative (C), or a salt thereof, comprise the step of coupling compound (A), or a salt thereof, with compound (B), or a salt thereof, in the presence of an ether or a hydrocarbon. The methods of this invention for recrystallizing a cyclic benzamidine derivative (C), or a salt thereof, comprise the steps of dissolving compound (C), or the salt thereof, in a mixed solvent comprising an alcohol and water, or a mixed solvent comprising an ether and water, and after dissolution, adding additional water to precipitate crystals of compound (C), or the salt thereof.

Methods for producing cyclic benzamidine derivatives

In the present invention, the methods of producing a fluorinated cyclic benzamidine derivative (A), or a salt thereof, comprise the step of reacting a specific novel compound with ammonia or imide. The methods of this invention for producing a morpholine-substituted phenacyl derivative (B), or a salt thereof, comprise reaction of a specific novel compound with morpholine, reaction of the product with a halogenating reagent, and deketalization of the product. The methods of this invention for a producing cyclic benzamidine derivative (C), or a salt thereof, comprise the step of coupling compound (A), or a salt thereof, with compound (B), or a salt thereof, in the presence of an ether or a hydrocarbon. The methods of this invention for recrystallizing a cyclic benzamidine derivative (C), or a salt thereof, comprise the steps of dissolving compound (C), or the salt thereof, in a mixed solvent comprising an alcohol and water, or a mixed solvent comprising an ether and water, and after dissolution, adding additional water to precipitate crystals of compound (C), or the salt thereof.

Methods for producing cyclic benzamidine derivatives

In the present invention, the methods of producing a fluorinated cyclic benzamidine derivative (A), or a salt thereof, comprise the step of reacting a specific novel compound with ammonia or imide. The methods of this invention for producing a morpholine-substituted phenacyl derivative (B), or a salt thereof, comprise reaction of a specific novel compound with morpholine, reaction of the product with a halogenating reagent, and deketalization of the product. The methods of this invention for a producing cyclic benzamidine derivative (C), or a salt thereof, comprise the step of coupling compound (A), or a salt thereof, with compound (B), or a salt thereof, in the presence of an ether or a hydrocarbon. The methods of this invention for recrystallizing a cyclic benzamidine derivative (C), or a salt thereof, comprise the steps of dissolving compound (C), or the salt thereof, in a mixed solvent comprising an alcohol and water, or a mixed solvent comprising an ether and water, and after dissolution, adding additional water to precipitate crystals of compound (C), or the salt thereof.

Biaromatic acetylene compounds having adamantyl group, pharmaceutical and cosmetic composition on their base

Изобретение относится к новым би-ароматическим соединениям ацетиленов с группой адамантила, которые имеют общую формулу и к использованию этих последних в фармацевтических и косметических составах.

DIHYDROPYRIDINE DERIVATIVES AND PROCEDURES FOR PREPARING THEREOF

Ethanamine derivatives their preparation and use in pharmaceutical compositions

The compounds of formula (II): ##STR1## in which R 1 is a hydrogen, fluorine, chlorine or bromine atom or a hydroxyl, hydroxymethyl, methyl, methoxyl, amino, formamido, acetamido, methylsulphonylamido, nitro, benzyloxy, methylsulphonylmethyl, ureido, trifluoromethyl or p-methoxybenzylamino group; R 2 is a hydrogen, fluorine, chlorine or bromine atom or a hydroxyl group; R 3 is a hydrogen, chlorine or bromine atom or a hydroxyl group, R 4 is a hydrogen atom or a methyl group; R 5 is a hydrogen atom or a methyl group; R 6 is a hydrogen, fluorine or chlorine atom or a methyl, methoxyl or hydroxy group; X is an oxygen atom or a bond; Y is an alkylene group of up to 6 carbon atoms or a bond; and Z is an alkylene, alkenylene or alkynylene group of up to 10 carbon atoms, have been found to possess anti-obesity and/or anti-hyperglycaemic activity.

Process for preparing derivatives of imidazole or their hydrochlorides

The invention provides compounds of the formula: wherein R 1 , R 2 and R 3 , which can be the same or different, are each selected from hydrogen, chloro, bromo, fluoro, methyl, ethyl, methoxy, amino, hydroxy and nitro; R 4 is hydrogen or alkyl of 1 to 7 carbon atoms; -X- is wherein R 5 is hydrogen, hydroxy or-OR 6 , and R 6 is alkyl of 1 to 7 carbon atoms or aryl of 6 to 10 carbon atoms; and their non-toxic pharmaceutically acceptable acid addition salts and mixtures thereof. Processes for the preparation and use of the subject compounds are described, as are novel pharmaceutical compositions comprising at least one of the subject compounds or their salts. The compounds and their non-toxic salts exhibit valuable pharmacological activity and are useful in the treatment of mammals, particularly as anti-hypertensive or anti-ulcer agents. Furthermore, they are useful as diuretic, sedative, analgesic, anti-inflammatory and tranquilizing agents.

Skin lightening compositions

This invention relates to compositions, compounds and methods for lightening skin, using active compounds having the structure: ##STR1## wherein: (i) each X is, independently, selected from the group consisting of halo, alkyl, substituted alkyl, aryl, OR, OCOR, COR, CONRR COOR, CN, SR, SOR, SO 2 R, SO 3 R and NRR, wherein X is other than hydroxy, amino and thio, if this X is attached ortho to the phenol hydroxy; (ii) m is an integer from 0 to 4; (iii) each R' and each R" is, independently, selected from the group consisting of hydrogen, halo, alkyl, substituted alkyl, aryl, OR, OCOR, OCRROR, COR, CR(OR)OR, CONRR, COOR, CRROR, CN, SR, and NRR; wherein halo, when it appears, is other than geminal to a hydroxy, NH 2 , or SH; (iv) R'" is alkyl or substituted alkyl; wherein when R'" is present, wherein when R'" is present and R' is also hydrogen, R" is other than hydrogen, hydroxy, halo, thio, cyano and amino; (v) each R is, independently, selected from the group consisting of hydrogen, alkyl, substituted alkyl and aryl; (vi) n is an integer from 1 to about 5, wherein at least one carbon in (C)n has other than alkyl or hydroxy as a substituent and (C)n adjacent to Z has other than amino, SH, CN or hydroxy as R'; (vii) Z is selected from the group consisting of O, NR, S, SO, SO 2 , PO 2 R and POR; (viii) wherein any carbon, when disubstituted, having as one substituent selected from the group consisting of hydroxy, amino, cyano and thiol, has the other substituent selected from the group consisting of hydrogen, alkyl, and aryl, whether this substituent is R' or R"; and to pharmaceutically acceptable salts of these compounds, stereoisomers and enantiomers thereof free from or mixed with other enantiomers or stereoisomers; and such compounds in compositions with a pharmaceutically-acceptable carrier thereof comprising a safe and effective amount of a subject skin lightening active.

A kind of acyclic nucleotide of replacement and method of related intermediates thereof of preparing

一种制备取代的无环核苷及其有关中间体的方 法，它可以通过下式(I)所示的对称的甲醛缩醛(其 中取代基R 1 -R 3 有具体的含意)，把取代基(II) 引入含氮杂环体系而形成无环核苷类似物。

Method for producing hydroxyl group-containing acetal compound

Retroviral protease inhibiting compounds

일반식 (A)의 레트로바이러스 프로테아제 억제 화합물에 대해 기술하였다. The retroviral protease inhibitory compounds of formula (A) have been described.

Method and intermediates for the synthesis of korupensamines

Activated isoquinolines and naphthalenes are disclosed which are useful to prepare korupensamines, michellamines and analogs thereof.

Method for producing purine derivative

The derivative of 2,3 dihydro furan, their preparation method and as their utilization for the intermediate of preparation tetrahydrofuran (THF)

本发明涉及以下化学式的2，3-二氢呋喃的衍生物： 这些衍生物在制备三唑基的四氢呋喃的方法中是用来作为中间体的，它们作为杀真菌剂是有效的。

Use of adamantyl-substituted polycyclic acetylene compounds in skin and hair treatment

본 발명은 아다만틸 기를 함유하는 하기 일반식(Ⅰ): The present invention provides the following general formula (I) containing an adamantyl group: 의 신규한 이방향족 아세틸렌 화합물, 인간 또는 수의학(특히, 피부병, 루마티스성 질환, 호흡기 질환, 심혈관계 질환 및 안과 질환)에서 사용하기 위한 약학 조성물 또는 화장품 조성물중에서의 상기 화합물의 용도에 관한 것이다. A novel biaromatic acetylene compound of, relates to the use of said compound in a pharmaceutical composition or cosmetic composition for use in human or veterinary medicine (especially dermatological, rheumatic, respiratory, cardiovascular and ophthalmic diseases).

Intermediates for the synthesis of bicyclo (2,2,1) heptanes and bicyclo (2,2,1) hept-2z-enes

Vitamin D compound, method for producing the compound, and intermediate thereof

Water-soluble polymer alkanal conjugates with human growth hormone

Disclosed is a compound having the structure of formula (I), wherein hGH represents a residue of human growth hormone comprising an N-terminal amino acid; and wherein each mPEG represents a methoxy-polyethylene glycol group having a molecular mass between about 18000 to about 22000 daltons.

Method for producing narrowly dispersed polyalkylene glycol derivative having amino group at terminal, and novel acetal group-containing alcohol compound and alkali metal salt thereof used therefor

Para-terphenyl compounds, method of their synthesis (versions) and pharmaceutical composition (versions)

FIELD: organic chemistry, chemical technology, pharmacy. SUBSTANCE: invention relates to novel para- -terphenyl compounds of the formula (I) or their pharmaceutically acceptable salts or hydrates that elicit immunosuppressive and antiallergic effect, in part, they elicit IgE-selective producing suppressive activity, to method of their synthesis and pharmaceutical compositions based on thereof. In compounds of the formula (I) X means -O-, -CH 2 -, -NR 14 where R 14 means hydrogen atom, optionally substituted lower alkyl, optionally substituted alkenyl or acetyl, or -S(O) p where p means a whole number from 0 to 2; Y means hydrogen atom, optionally substituted lower alkyl, optionally substituted lower alkenyl, optionally substituted lower alkynyl, optionally substituted acyl, optionally substituted cycloalkyl, optionally substituted cycloalkenyl; Y can mean optionally substituted lower alkoxy-group if X means -CH 2 - and can mean optionally substituted lower alkoxycarbonyl, optionally substituted lower alkylsulfonyl or optionally substituted arylsulfonyl if X means -O- or -NR 14 ; R 1 -R 13 can mean different values indicated in the invention claim, for example, R 1 and R 2 ; R 1 and R 4 ; R 6 and R 7 ; R 8 and R 9 , R 11 and -X-Y or R 13 and -X-Y taken in common can form 5- or 6-membered ring that can comprise one or more atoms taken among O, S or NR 15 . Methods of synthesis of compounds of the formula (I) involve interaction of different phenyl fragments corresponding to fragments of the formula (I). Pharmaceutical compositions comprise compounds of the formula (I), its pharmaceutically acceptable salt or hydrate and pharmaceutically acceptable vehicle. EFFECT: improved methods of synthesis, valuable medicinal properties of compounds. 15 cl, 4 dwg, 334 tbl 0$52100СссС ПЧ сэ (19) РОССИЙСКОЕ АГЕНТСТВО ПО ПАТЕНТАМ И ТОВАРНЫМ ЗНАКАМ ВИ "” 2 200 730‘ (51) МПК” 13) С2 С 07С 25/18, 43/20, 217/80, 233/80, А 61 К 31/235, 31/18, 31/185, 31/165, А 61 Р 37/08 12) ОПИСАНИЕ ...

Retroviral protease inhibitory compounds, methods for their preparation and pharmaceutical compositions containing them

본 발명은 레트로바이러스성 프로테아제를 억제하기 위한 일반식(A)의 화합물 및 조성물 및 방법; 당해 화합물 또는 이의 산 부가염의 제조방법에 관한 것이다. The present invention relates to compounds and compositions and methods of the general formula (A) for inhibiting retroviral proteases; To a process for producing the compound or an acid addition salt thereof. 상기식에서, 각각의 치환체들은 특허청구의 범위 제 1항에서 정의한 바와 같다. Wherein each substituent is as defined in claim 1.

STILBENIC COMPOUNDS WITH ADAMANTYL GROUP, COMPOSITIONS CONTAINING SAME, AND USES

Bi-aromatic acetylene compounds with adamantyl group, pharmaceutical and cosmetic composition based thereon

FIELD: pharmaceutical industry. SUBSTANCE: present invention describes novel binaromatic acetylene, compounds with adamantyl group of formula (I): wherein R 1 is H, -CH 2 -O-H-,-CH 2 -O-CO-CH 3 ,, OH, -O-(CH 2 )-(CO) n -Het, -CH 2 ) p -CO-H, (CH 2 ) p CO-CH 3 ,, -CH 2 ) p CONH 2 , Het is heterocycle; Ar is substituted or unsubstituted pyridyl, phenyl, naphthalyl; R 2 is H, -O-CH 2 -O-CH 2 -CH 2 -OCH 3 ; -OR 12 straight or branched alkyl containing 1-20 carbon atoms; R 3 is -O-CH 2 -O-CH 2 -CH 2 -OCH 3 ; m is 1 or 2; n is 0 or 1; p is 0 or 1; and X is H. The present invention also describes pharmaceutical or cosmetic compositions containing effective amount of compound (I) as active ingredient, and pharmaceutical or cosmetic additives. EFFECT: improved properties of the pharmaceutical and cosmetic compositions. 16 cl, 1 tbl 999 гс ПЧ Го РОССИЙСКОЕ АГЕНТСТВО ПО ПАТЕНТАМ И ТОВАРНЫМ ЗНАКАМ (19) (51) МПК ВИ "” 2 125 554 ' 13) СЛ С 07 С 63/66, А 61 К 31/01 12) ОПИСАНИЕ ИЗОБРЕТЕНИЯ К ПАТЕНТУ РОССИЙСКОЙ ФЕДЕРАЦИИ (21), (22) Заявка: 95106684/04, 25.04.1995 (30) Приоритет: 26.04.1994 ЕК 9405018 (46) Дата публикации: 27.01.1999 (56) Ссылки: ЕР 315071, 1988. ЕР 0514264, 1993. $. Сасспе 4 а!. Гегапедгоп Гевег$, 1986, у. 27, р.3931-4. (98) Адрес для переписки: 103735 Москва, ул.Ильинка 5/2 СОЮЗПАТЕНТ (71) Заявитель: С.И.Р.Д. Галдерма (ЕК) (72) Изобретатель: Жан-Мишель Бернардон (ЕК), Брюно Шарпантье (ЕК) (73) Патентообладатель: С.И.Р.Д. Галдерма (ЕК) (54) БИ-АРОМАТИЧЕСКИЕ АЦЕТИЛЕНОВЫЕ СОЕДИНЕНИЯ С ГРУППОЙ АДАМАНТИЛА, ФАРМАЦЕВТИЧЕСКАЯ И КОСМЕТИЧЕСКАЯ КОМПОЗИЦИИ НА ИХ ОСНОВЕ (57) Реферат: Изобретение относится к новым би-ароматическим соединениям ацетиленов с группой адамантила формулы (|), обладающим активностью в отношении дифференциации и пролиферации клеток. х где К. представляет Н, -СН 2-О-Н, -СН 2-О-СО-СНз, ОН, -О-(СН2) -(СО)- -Н%, -(СН2)>-СО-Н, -СН?2)р-СО-СИз, -СН2)СОМНЬ>, Не-гетероцикл; Аг - замещенный или незамещенный пиридил, фенил, нафталил: К2 - Н, -О-СН?2-О-СН2-СН?2- ...

Positive radiation-sensitive mixture and radiation sensitive recording material produced therefrom

요약없음 No summary

Naphthalene derivatives

本文介绍了一种下式所示、适用作新型药物的萘衍生物。

Process for preparing derivatives of imidazole

The invention provides compounds of the formula: wherein R 1 , R 2 and R 3 , which can be the same or different, are each selected from hydrogen, chloro, bromo, fluoro, methyl, ethyl, methoxy, amino, hydroxy and nitro; R 4 is hydrogen or alkyl of 1 to 7 carbon atoms; -X- is wherein R 5 is hydrogen, hydroxy or-OR 6 , and R 6 is alkyl of 1 to 7 carbon atoms or aryl of 6 to 10 carbon atoms; and their non-toxic pharmaceutically acceptable acid addition salts and mixtures thereof. Processes for the preparation and use of the subject compounds are described, as are novel pharmaceutical compositions comprising at least one of the subject compounds or their salts. The compounds and their non-toxic salts exhibit valuable pharmacological activity and are useful in the treatment of mammals, particularly as anti-hypertensive or anti-ulcer agents. Furthermore, they are useful as diuretic, sedative, analgesic, anti-inflammatory and tranquilizing agents.

SALT, ACID GENERATOR, RESIST COMPOSITION AND METHOD FOR PRODUCING RESIST PATTERN

L’invention a pour objet de fournir un sel capable de produire un motif de résist ayant une uniformité CD (CDU) satisfaisante, un générateur d’acide et une composition de résist incluant ceux-ci. L’invention concerne un sel représenté par la formule (I) telle que définie dans la revendication 1, un générateur et une composition de résist incluant le sel de formule (I), où R1 et R2 représentent chacun indépendamment un groupe hydroxy, -O-R10, -O-CO-O-R10 ou -O-L1-CO-O-R10; L1 représente un groupe alcanediyle ayant 1 à 6 atomes de carbone; R4, R5, R7 et R8 représentent chacun indépendamment un atome d’halogène, un groupe fluorure d’alkyle ayant 1 à 12 atomes de carbone ou un groupe hydrocarboné ayant 1 à 18 atomes de carbone, le groupe hydrocarboné peut avoir un substituant, et -CH2- inclus dans le groupe hydrocarboné peut être remplacé par -O-, -CO-, -S- ou -SO2-; R10 représente un groupe labile en milieu acide; X1 et X2 représentent chacun indépendamment un atome d’oxygène ou un atome de soufre; m1 représente un entier de 1 à 5, m2 et m8 représentent un entier de 0 à 5, m4, m5 et m7 représentent un entier de 0 à 4; et AI- représente un anion organique. It is an object of the invention to provide a salt capable of producing a resist pattern having satisfactory CD uniformity (CDU), an acid generator and a resist composition including these. The invention relates to a salt represented by formula (I) as defined in claim 1, a generator and a resist composition including the salt of formula (I), wherein R1 and R2 each independently represent a hydroxy group, -O -R10, -O-CO-O-R10 or -O-L1-CO-O-R10; L1 represents an alkanediyl group having 1 to 6 carbon atoms; R4, R5, R7 and R8 each independently represent a halogen atom, an alkyl fluoride group having 1 to 12 carbon atoms or a hydrocarbon group having 1 to 18 carbon atoms, the hydrocarbon group may have a substituent, and -CH2- included in the hydrocarbon group can be replaced by -O-, -CO-, -S- or -SO2-; R10 represents a ...

COMPOUND, RESIN, RESIST COMPOSITION AND METHOD FOR PRODUCING RESIST PATTERN

L'invention concerne un composé représenté par la formule (I) telle que définie dans la revendication 1, une résine et une composition de résist, où R1 un atome d'hydrogène, un atome d'halogène ou un groupe alkyle qui peut avoir un atome d'halogène,; L1 représente une liaison simple ou -CO-O- ; R3 représente un groupe alkyle, et -CH2- inclus dans le groupe peut être remplacé par -O- ou -CO; R4 représente un atome de fluor, un groupe fluorure d'alkyle ou un groupe alkyle, et -CH2- inclus dans le groupe fluorure d'alkyle et le groupe alkyle peut être remplacé par -O- ou -CO-; R5 représente un atome d'hydrogène, un groupe alkylcarbonyle ou un groupe labile aux acides; m2 et m3 représentent un entier de 1 à 3, m4 représente un entier de 0 à 2 et m5 représente 1 ou 2, où 3 ≤ m2 + m3 + m4 + m5 ≤ 5. Disclosed are a compound represented by formula (I) as defined in claim 1, a resin and a resist composition, wherein R1 is a hydrogen atom, a halogen atom or an alkyl group which may have a halogen atom,; L1 represents a single bond or -CO-O-; R3 represents an alkyl group, and -CH2- included in the group may be replaced by -O- or -CO; R4 represents a fluorine atom, an alkyl fluoride group or an alkyl group, and -CH2- included in the alkyl fluoride group and the alkyl group may be replaced by -O- or -CO-; R5 represents a hydrogen atom, an alkylcarbonyl group or an acid labile group; m2 and m3 represent an integer from 1 to 3, m4 represents an integer from 0 to 2, and m5 represents 1 or 2, where 3 ≤ m2 + m3 + m4 + m5 ≤ 5.

Immunological detection method of pyrethroid compounds, hapten compounds, hapten compound intermediates, immunogens and antibodies

SKIN LIGHTENING COMPOSITIONS

본 발명은 하기 구조식(Ⅰ) 또는 (Ⅱ)를 갖는 활성 화합물을 사용하여 피부를 미백시키는 조성물, 화합물 및 방법, 및 이들 화합물의 약학적으로 허용가능한 염, 다른 거울이성질체 또는 입체이성질체를 갖지 않거나 또는 이들과 혼합된 그의 입체이성질체 및 거울이성질체; 및 환자의 피부를 미백시키는 활성성분 안전 효과량을 포함하는, 약학적으로 허용되는 담체와의 조성물을 이루는 이들 화합물에 관한 것이다. 상기 식에서, (ⅰ) 각각의 X는 독립적으로 할로, 알킬, 치환된 알킬, 아릴, OR, OCOR, COR, CONRR, COOR, CN, SR, SOR, SO 2 R, SO 3 R 및 NRR로 이루어진 군으로부터 선택되고, X는 페놀 하이드록시에 대해 오르토 위치에 결합되는 경우 하이드록시, 아미노 및 티오가 아니며; (ⅱ) m은 0 내지 4의 정수이고; (ⅲ) 각각의 R' 및 R"은 독립적으로 수소, 할로, 알킬, 치환된 알킬, 아릴, OR, OCOR, OCRROR, COR, CR(OR), OR, CONRR, COOR, CRROR, CN, SR 및 NRR로 이루어진 군으로부터 선택되며, 존재하는 경우 할로는 하이드록시와 동일한 탄소상에 존재하지 않고; (ⅳ) R 은 알킬 또는 치환된 알킬이고, R 이 존재하고 R'이 또한 수소인 경우 R"은 수소, 하이드록시, 할로, 티오, 시아노 및 아미노가 아니며; (ⅴ) 각각의 R은 독립적으로 수소, 알킬, 치환된 알킬 및 아릴로 이루어진 군으로부터 선택되고; (ⅵ) n은 1 내지 약 5의 정수이고, (C) n 중 하나 이상의 탄소는 치환기로서 알킬 또는 하이드록시 이외의 것을 갖고, Z에 인접한 (C) n 은 R'으로서 아미노, SH, CN 또는 하이드록시 이외의 것을 가지며; (ⅶ) Z는 O, NR, S, SO, SO 2 , PO 2 R 및 POR로 이루어진 군으로부터 선택되고; (ⅷ) 하이드록시, 아미노, 시아노 및 티올로 이루어진 군으로부터 선택되는 하나의 치환제를 갖는 임의의 탄소는 이치환되는 경우 이 치환기가 R' 또는 R"인지에 관계없이 수소, 알킬 및 아릴로 이루어진 군으로부터 선택되는 다른 치환기를 갖는다.

Low-salt method of producing polysulphide

FIELD: chemistry.SUBSTANCE: invention relates to a method of producing polysulphide by low-salt method. Method of producing polysulphide involves a step of reacting bis(2-haloalkyl) formal with sodium polysulphide (i) or a combination of sodium and sulfur bisulphide (ii). Reaction is carried out in the presence of a prepolymer of formula (I) X-(R-O)-CH-O-(R-O)-CH-(O-R)-X (I), in which Rand Rcan be identical or different, selected from alkane chains containing 2–10 carbon atoms, X is a halogen atom, n, m and p are integers which can be identical or different and have a value in range from 1 to 6. Reaction is carried out in the absence of a dihaloated alkane.EFFECT: invention enables to obtain a polysulphide polymer with low salt content, characterized by good chemical resistance, good compatibility with plasticisers and polar surfaces.11 cl, 8 tbl, 5 ex РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 2 692 777 C2 (51) МПК C08G 75/00 (2006.01) C08G 75/02 (2006.01) C08G 75/14 (2006.01) C08G 65/00 (2006.01) C08G 63/00 (2006.01) C08L 81/00 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА C08L 81/02 (2006.01) ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ C07C 1/00 (2006.01) C07C 321/04 (2006.01) C07C 323/12 (2006.01) (12) ОПИСАНИЕ ИЗОБРЕТЕНИЯ К ПАТЕНТУ (52) СПК C08G 75/00 (2019.02); C08G 75/14 (2019.02); C08L 81/00 (2019.02); C08L 81/02 (2019.02) 2017124155, 16.12.2015 (24) Дата начала отсчета срока действия патента: 16.12.2015 Дата регистрации: (72) Автор(ы): МЕНЦЕЛЬ, Манфред (DE), БУРКХАРДТ, Фолькер (DE), КЛОБЕС, Олаф (DE) Приоритет(ы): (30) Конвенционный приоритет: (56) Список документов, цитированных в отчете о поиске: US 4,124,645 A, 07.11.1978. WO 17.12.2014 EP 14198572.1 (43) Дата публикации заявки: 18.01.2019 Бюл. № 2 2012/139984 A1, 18.10.2012. US 5,430,192 A, 04.07.1995. US 2003/0050511 A1, 13.03.2003. (45) Опубликовано: 27.06.2019 Бюл. № 18 2 6 9 2 7 7 7 (73) Патентообладатель(и): АКЦО НОБЕЛЬ КЕМИКАЛЗ ИНТЕРНЭШНЛ Б.В. (NL) 27.06.2019 R U (21)(22) Заявка: C 2 C 2 (85) Дата начала рассмотрения заявки PCT ...

Process for preparation of polysulphide

Изобретение относится к способу получения полисульфида. Описан способ получения полисульфида, включающий стадию проведения реакции бис(2-дигалогеналкил)формаля и дигалогеналкана с послульфидом натрия в присутствии преполимера структуры (I): X-(R 2 -O) n -CH 2 -O-(R 1 -O) m -CH 2 -(O-R 2 ) p -X (I), в которой R 1 и R 2 могут быть одинаковыми или разными и выбраны из алкановых цепей, содержащих 2-10 атомов углерода, X представляет собой атом галогена и n, m и p представляют собой целые числа, которые могут быть одинаковыми или разными и иметь значение в диапазоне 1-6. Также описан способ получения полисульфида, включающий стадию проведения реакции бис(2-дигалогеналкил)формаля и дигалогеналкана с полисульфидом натрия в присутствии преполимера, получаемого проведением реакции полиола с (пара)формальдегидом и галогеноспиртом в присутствии кислого катализатора. Технический результат – получение полисульфида с улучшенной химической стойкостью и совместимостью с разнообразными полярными поверхностями и пластификаторами. 2 н. и 8 з.п. ф-лы, 3 табл., 2 пр. РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 2 662 433 C2 (51) МПК C07C 41/56 (2006.01) C07C 43/11 (2006.01) C08G 75/16 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ОПИСАНИЕ ИЗОБРЕТЕНИЯ К ПАТЕНТУ (52) СПК C07C 41/56 (2018.02); C07C 43/11 (2018.02); C08G 75/16 (2018.02) (21)(22) Заявка: 2015156258, 13.06.2014 (24) Дата начала отсчета срока действия патента: Дата регистрации: 26.07.2018 17.06.2013 EP 13172268.8 (43) Дата публикации заявки: 24.07.2017 Бюл. № 21 (73) Патентообладатель(и): АКЦО НОБЕЛЬ КЕМИКАЛЗ ИНТЕРНЭШНЛ Б.В. (NL) (56) Список документов, цитированных в отчете о поиске: US 2553206 A1, 15.05.1951. US (45) Опубликовано: 26.07.2018 Бюл. № 21 2382874 A1, 14.08.1945. US 4124645 A1, 07.11.1978. US 20030050511 A1, 13.03.2003. RU 2220158 C2, 27.12.2003. (85) Дата начала рассмотрения заявки PCT на национальной фазе: 18.01.2016 2 6 6 2 4 3 3 Приоритет(ы): (30) Конвенционный приоритет: R U 13.06.2014 (72) ...

Process for rendering a surface biocompatible, and articles containing the same

A compound of formula: ##STR1## in which X 1 is a reactive group that can react to form a covalent bond with a reactive group on the surface of a material to be rendered biocompatible, X 2 is a group --O.sup.⊖ or a precursor of such a group, n is 2, 3 or 4, Y is a group --N.sup.⊕ R 3 A.sup.⊖ wherein each R, which may be the same or different, is a C 1 -C 4 alkyl group and A.sup.⊖ is an anion present when X 2 is an electrically neutral group or Y is ##STR2## wherein R 1 together with X 2 forms a direct bond between the nitrogen and the phosphorus atoms.

Process for production of benzaldehyde compound

本发明公开了一种由式(3)表示的苯甲醛缩醛化合物：[其中，Q表示氢原子或卤素原子；Ar表示可以被选自由具有1至4个碳原子的烷基和卤素原子组成的组中的至少一个成员取代的苯基；并且R表示具有1至4个碳原子的烷基]。

Process for the production of monoethers of hydroquinone and quinol ketales as intermediates thereof

Monoethers of hydroquinone are prepared by reduction of monoketals of p-benzoquinone, preferably using complex hydrides of boron or aluminium, with a sulphite or molecular hydrogen in the presence of a nickel catalyst until one mole of H2/mole of p-benzoquinone monoketal is absorbed in an inert solvent to give the corresponding quinol ketals and treatment of these with an acid. The quinol ketals formed as intermediates here are novel compounds. The monoethers of hydroquinone are precursors, intermediates and final products in various subject areas.

FLUOROVINYLETERS AND POLYMERS THAT CAN BE OBTAINED.

Positive-type radiation-sensitive mixture, positive-type radiation-sensitive recording material and production method thereof

Preparation for clearing the skin

This invention relates to compositions, compounds and methods for lightening skin, using active compounds having the structure (I) or (II) wherein: (i) each X is, independently, selected from the group consisting of halo, alkyl, substituted alkyl, aryl, OR, OCOR, COR, CONRR, COOR, CN, SR, SOR, SO2R, SO3R and NRR, wherein X is other than hydroxy, amino and thio, if this X is attached ortho to the phenol hydroxy; (ii) m is an integer from 0 to 4; (iii) each R' and R'' is, independently, selected from the group consisting of hydrogen, halo, alkyl, substituted alkyl, aryl, OR, OCOR, OCRROR, COR, CR(OR)OR, CONRR, COOR, CRROR, CN, SR, and NRR; wherein halo, when it appears, is other than geminal to a hydroxy, NH2, or SH; (iv) R''' is alkyl or substituted alkyl; wherein when R''' is present, and R' is also hydrogen, R'' is other than hydrogen, hydroxy, halo, thio, cyano and amino; (v) each R is, independently, selected from the group consisting of hydrogen, alkyl, substituted alkyl and aryl; (vi) n is an integer from 1 to about 5, wherein at least one carbon in (C)n has other than alkyl or hydroxy as a substituent and (C)n adjacent to Z has other than amino, SH, CN or hydroxy as R'; (vii) Z is selected from the group consisting of O, NR, S, SO, SO2, PO2R and POR; (viii) wherein any carbon, when disubstituted, having one substituent selected from the group consisting of hydroxy, amino, cyano and thiol, has the other substituent selected from the group consisting of hydrogen, alkyl, and aryl, whether this substituent is R' or R''; and to pharmaceutically acceptable salts of these compounds, stereoisomers and enantiomers thereof free from or mixed with other enantiomers or stereoisomers; and such compounds in compositions with a pharmaceutically-acceptable carrier thereof comprising a safe and effective amount of a subject skin lightening active.

Derivatives of sobetirome

Disclosed are halo substituted derivative compounds of sobetirome with improved pharmacological characteristics relative to sobetirome, pharmaceutical compositions that include those compounds and methods of treating diseases such as neurodegenerative disorders using those pharmaceutical compositions.

Method of fighting weeds

Condensation material is cladded in liquid crystal compounds, liquid-crystal composition, liquid crystal and possesses these liquid crystal display cells

提供一种维持所期望的物性，且同时对其他双液晶原化合物或现有液晶显示元件中所使用的液晶性化合物、液晶组合物、以手性掺杂剂、抗氧化剂或紫外线吸收剂为代表的添加剂、聚合性液晶化合物具有高溶解性的双液晶原化合物。提供式(1)所表示的化合物、包含所述化合物的液晶组合物、由所述液晶组合物所获得的液晶内包复合纤维及由所述液晶内包复合纤维所获得的液晶显示元件。MG 1 ‑Z a ‑Sp‑Z b ‑MG 2 (1)。式(1)中，MG 1 及MG 2 分别独立地为液晶原基；Z a 及Z b 独立地为例如碳数1～4的亚烷基；Sp具有式(sp‑1)所表示的非手性结构，‑α‑X‑α‑(sp‑1)。式(sp‑1)中，α分别独立地为例如碳数1～20的直链亚烷基；X由式(I)、式(II)或式(III)所表示式(I)中，Ra为碳数1～10的烷基；式(II)中，Rb及Rc分别独立地为例如碳数1～10的烷基；式(III)中，Q为例如氧原子。

ADAMANTYL-GROUPED STILBENIC COMPOUNDS, COMPOSITIONS CONTAINING SAME AND USES THEREOF

L'invention concerne de nouveaux composés stilbéniques qui présentent comme formule générale (1): (CF DESSIN DANS BOPI) ainsi que l'utilisation de ces derniers dans des compositions pharmaceutiques destinées à un usage en médecine humaine ou vétérinaire (affections dermatologiques, rhumatismales, respiratoires, cardiovasculaires et ophtalmologiques notamment), ou bien encore dans des compositions cosmétiques. The invention relates to new stilbenic compounds which have as general formula (1): (CF DRAWING IN BOPI) as well as the use of the latter in pharmaceutical compositions intended for use in human or veterinary medicine (dermatological, rheumatic, and respiratory, cardiovascular and ophthalmological in particular), or even in cosmetic compositions.

2-FLUORETHOXY-BENZENIC DERIVATIVES, THEIR PREPARATION AND INSECTICIDE AGENTS CONTAINING SAME

DERIVES DE FORMULE GENERALE: (CF DESSIN DANS BOPI) DANS LAQUELLE X REPRESENTE UN ATOME D'OXYGENE OU DE SOUFRE, R ET R SONT H OU UN GROUPE ALKYLE, N REPRESENTE 0 OU 1, ET A REPRESENTE UN GROUPE DE FORMULE GENERALE: (CF DESSIN DANS BOPI) DANS LAQUELLE R ET R REPRESENTENT H, UN HALOGENE, UN GROUPE ALKYLE, ALKOXY, ALKYLTHIO, HALOGENOALKYLE, HALOGENO-ALKYLTHIO, OU ENSEMBLE UN METHYLENEDIOXY, R ET R REPRESENTENT H OU UN ALKYLE, ET P ET M SONT 0 OU 1. AGENTS INSECTICIDES OU ACARICIDES. DERIVATIVES OF GENERAL FORMULA: (CF DRAWING IN BOPI) IN WHICH X REPRESENTS AN ATOM OF OXYGEN OR SULFUR, R AND R ARE H OR AN ALKYL GROUP, N REPRESENTS 0 OR 1, AND A REPRESENTS A GROUP OF GENERAL FORMULA: ( CF DRAWING IN BOPI) IN WHICH R AND R REPRESENT H, A HALOGEN, AN ALKYL GROUP, ALKOXY, ALKYLTHIO, HALOGENOALKYL, HALOGENO-ALKYLTHIO, OR TOGETHER A METHYLENEDIOXY, R AND R AND R OR UNMETHYLENEDIOXY, R AND R AND R OR UNPRESENT 0 AND M REPRESENT OR 1. INSECTICIDAL OR ACARICIDAL AGENTS.

PROCESS FOR THE PREPARATION OF (7E-9Z) -ALCADIENOLS DERIVATIVES

NOVEL L-OXA-, THIA- AND AZA-SPIROCYCLO-BENZENE-ACETAMIDES AND BENZAMIDES, THEIR PREPARATION PROCESS AND THE PHARMACEUTICAL COMPOSITION CONTAINING THEM

NEW BICYCLIC G-LACTONE AND G-HEMIACETAL DERIVATIVES

Chloral - hemiacetals and hemi-mercaptals - herbicides effective against monocotyledons

PHENOXY-PHENOXY-ALKANOIC ACID DERIVATIVES AND RELATED COMPOUNDS, FOR USE IN HERBICIDE PRODUCTS

Synthetic intermediates for preparing retroviral protease inhibiting compounds

본 발명은 레트로바이러스 프로테아제 억제 화합물 제조용 합성 중간체인 구조식 의 화합물 또는 이의 염 및 일반식 의 화합물 [여기서, R은 수소 또는 저급 알킬이다]에 관한 것이다.

Production method of an insect pheromone

ABSTRACT OF THE DISCLOSURE A process for producing 3,3,7-trimethyl-2,9-dioxatricyclo[3.3.1.04,7]nonane useful as an insect pheromone and having the formula,

NOVEL PHENOLIC COMPOUNDS DERIVED FROM DIALCOXYETHANALS, THEIR PREPARATION PROCESS AND THEIR APPLICATION

1. Nouveaux composés phénoliques de formule (I) (CF DESSIN DANS BOPI) - R = groupement dialcoxyméthyle en C3 -C17 , groupement dioxolan -1,3 yl-2 éventuellement substitué sur les sommets 4 et/ou 5 par un ou plusieurs alkyles en C1 -C8 ou groupement dioxan-1,3 yl-2 éventuellement substitué sur les sommets 4 et/ou 5 et/ou 6 par un ou plusieurs alkyles en C1 -C8 . - n = 1, 2 ou 3, le ou les groupements (CF DESSIN DANS BOPI) sont en position o et/ou p du OH du cycle- m = de 0 à 4-n, X = groupement fonctionnel tel que OH ou Hal ou groupement alkyle ou alcoxy en C1 -C8 ou aryle en C5 -C12 et éventuellement 1 ou 2 hétéroatomes comme N ou O, ou carboxy ou -CO-Y où Y = alkyle ou alkoxy en C1 -C8 ou amido ou amino ou thiol, à condition qu'une au moins des positions ortho ou para du cycle phénolique soit substituée par un hydrogène, ainsi que leurs sels avec les métaux alcalins, les métaux alcalino-terreux et les amines. 1. New phenolic compounds of formula (I) (CF DRAWING IN BOPI) - R = dialkoxymethyl group in C3 -C17, dioxolan group -1,3 yl-2 optionally substituted on the vertices 4 and / or 5 by one or more alkyls in C1 -C8 or dioxan-1,3 yl-2 group optionally substituted on the vertices 4 and / or 5 and / or 6 by one or more alkyls in C1 -C8. - n = 1, 2 or 3, the group (s) (CF DRAWING IN BOPI) are in the o and / or p position of the OH of the ring - m = from 0 to 4-n, X = functional group such as OH or Hal or alkyl or alkoxy in C1 -C8 or aryl in C5 -C12 and optionally 1 or 2 heteroatoms such as N or O, or carboxy or -CO-Y where Y = alkyl or alkoxy in C1 -C8 or amido or amino or thiol, provided that at least one of the ortho or para positions of the phenolic ring is substituted by a hydrogen, as well as their salts with the alkali metals, the alkaline earth metals and the amines.

NOVEL L-OXA-, THIA- AND AZA-SPIROCYCLO-BENZENE-ACETAMIDES AND BENZAMIDES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITION CONTAINING SAME

L'INVENTION A TRAIT AU DOMAINE DE LA CHIMIE DES MEDICAMENTS. ELLE CONCERNE DES NOUVEAUX COMPOSES DU TYPE MONO-OXA-,THIASPIROCYCLO-BENZENE-ACETAMIDE ET-BENZAMIDE DE FORMULE GENERALE: (CF DESSIN DANS BOPI) PAR EXEMPLE, LE ()-(5A,7A,8B) -3,4-DICHLORO-N-METHYL-N-7-(1-PYRROLIDINYL)-1-OXASPIRO4.5DEC-8-YLBENZENE-ACETAMIDE ET SES SELS PHARMACOLOGIQUEMENT ACCEPTABLES. LES COMPOSES DE L'INVENTION SONT UTILES COMME COMPOSES ANALGESIQUES PRESENTANT UN FAIBLE RISQUE DE DEPENDANCE PHYSIQUE COMPARATIVEMENT A LA MORPHINE ET LA METHODONE, AVEC DE FAIBLES EFFETS DYSPHORIQUES SECONDAIRES. CERTAINS DE CES COMPOSES ONT UNE PUISSANTE ACTIVITE ANALGESIQUE LORSQU'ILS SONT ADMINISTRES PAR VOIE ORALE ET CERTAINS EXERCENT DE LEGERS EFFETS SECONDAIRES SEDATIFS SUR LE SYSTEME NERVEUX CENTRAL. THE INVENTION RELATES TO THE FIELD OF THE CHEMISTRY OF DRUGS. IT CONCERNS NEW COMPOUNDS OF THE MONO-OXA-, THIASPIROCYCLO-BENZENE-ACETAMIDE AND-BENZAMIDE TYPE OF GENERAL FORMULA: (CF DRAWING IN BOPI) FOR EXAMPLE, THE () - (5A, 7A, 8B) -3,4-DICHLORO -N-METHYL-N-7- (1-PYRROLIDINYL) -1-OXASPIRO4.5DEC-8-YLBENZENE-ACETAMIDE AND ITS PHARMACOLOGICALLY ACCEPTABLE SALTS. THE COMPOUNDS OF THE INVENTION ARE USEFUL AS ANALGESIC COMPOUNDS PRESENT A LOW RISK OF PHYSICAL DEPENDENCE COMPARED TO MORPHINE AND METHODONE, WITH LOW DYSPHORIC SIDE EFFECTS. SOME OF THESE COMPOUNDS HAVE POWERFUL ANALGESIC ACTIVITY WHEN ADMINISTERED ORALLY AND SOME EXERCISE SLIGHT SEDATIVE SIDE EFFECTS ON THE CENTRAL NERVOUS SYSTEM.

New acetylenated bi-aromatic compounds with adamantyl group, pharmaceutical and cosmetic compositions containing them and uses.

Patent FR2146893B1

Process for the manufacture of oxygenates

.alpha.-Hydroxycarbonyl compounds are obtained from aldehydes or ketones by forming an acetal or ketal which is decomposed to a vinyl ether. The ether is selectively oxidized under conditions yielding an .alpha.-hydroxy-aldehyde or ketone with the carbonyl group protected. The last-mentioned compounds are valuable sources for other functional organic molecules, for example lactic acid.

A process for the preparation of substituted acyclic nucleosides,and intermediates occurring therein

Novel phenolic derivatives of dialkoxyethanals, method of preparation and use thereof

Phenolic compounds, derivatives of dialkoxyethanals and method for their preparing

FIELD: organic chemistry, chemical technology. SUBSTANCE: invention relates to phenolic compounds, derivatives of dialkoxyethanals that are intermediate substances in organic synthesis and can be used as cross-linking agents of phenolic type no evolving formaldehyde also. Phenolic compounds are described of the general formula (I): wherein: R means (C 3 -C 17 )-dialkoxymethyl, 1,3-dioxolan-2-yl substituted possibly at positions 4 and/or 5 with one or some (C 1 -C 8 )-alkyls, or 1,3-dioxane-2-yl substituted possibly at positions 4 and/or 5, and/or 6 with one or some (C 1 -C 8 )-alkyls; n = 1, 2 or 3, and group or groups of the formula: -CH(OH)-R are at ortho-position and/or at para-position with respect to OH in the cycle group; m = from 0 to 4-n; X means the functional group, such as OH or Hal, or (C 1 -C 8 )-alkyl, or (C 1 -C 8 )-alkoxyl, or (C 5 -C 12 )-aryl comprising in the known cases 1 or 2 heteroatoms, such as nitrogen or oxygen, or carboxy-group, or the group -CO-Y wherein Y means (C 1 -C 8 )-alkyl or (C 1 -C 8 )-alkoxyl, or amido-group, or amino-group, or thiol-group under condition that at least on of ortho- or para-positions in phenol cycle must be substituted with hydrogen atom, and their salts with alkaline metals, earth-alkaline metals and amines also. Method for preparing indicated phenolic compounds involves interaction of the corresponding substituted phenol wherein at least one ortho- or para-position in phenol cycle must be substituted with hydrogen atom with substituted aldehyde in the presence of a base. Invention provides preparing new compounds that can be used as cross-linking agents no evolving formaldehyde and as intermediate compounds used in organic synthesis. EFFECT: improved method for preparing. 13 cl, 1 dwg, 10 ex ÐÎÑÑÈÉÑÊÀß ÔÅÄÅÐÀÖÈß (19) RU (51) ÌÏÊ 7 (11) 2 257 372 (13) C2 C 07 C 43/178, 37/20, 39/06 ÔÅÄÅÐÀËÜÍÀß ÑËÓÆÁÀ ÏÎ ÈÍÒÅËËÅÊÒÓÀËÜÍÎÉ ÑÎÁÑÒÂÅÍÍÎÑÒÈ, ÏÀÒÅÍÒÀÌ È ÒÎÂÀÐÍÛÌ ÇÍÀÊÀÌ (12) ÎÏÈÑÀÍÈÅ ÈÇÎÁÐÅÒÅÍÈß Ê ÏÀÒÅÍÒÓ (21), (22) Çà ...

Retroviral protease inhibiting compounds

A retroviral protease inhibiting compound of formula (A) is disclosed -(see formula I)

Water-soluble polymer alkanals

본 발명은 수용성 중합체, 예컨대 폴리(에틸렌 글리콜) 의 알카날 유도체, 이들의 대응 수화물 및 아세탈, 그리고 상기 중합체 알카날의 제조 및 사용 방법에 관한 것이다. 본 발명의 중합체 알카날은 고순도로 제조되며, 저장 안정성을 나타낸다. The present invention relates to alkanal derivatives of water soluble polymers such as poly (ethylene glycol), their corresponding hydrates and acetals, and methods of making and using such polymer alkanals. The polymer alkanals of the invention are prepared in high purity and exhibit storage stability.

POLYALCOXY THERMAL FORMAL

Process for producing of naphthalene derivative

Сущность изобретени . Продукт - производное нафталина общей формулы: ИЛИ Изобретение относитс  к новому способу получени  производного нафталина, обладающего высокой гилолипидемической активностью, В частности, изобретение относитс  к производным 2-(3-и) или 4-низший алкокси- фенил-2,3-бис(низший алкоксикарбонил)-4- оксинафталина и.их сол м. Цель заключаетс  в упрощении процесса и повышении его селективности. R , R - низша  алкильна  группа, R , R - низша  алкоксигруппа,кольцо А - замещенное бензольное кольцо v ROИЛИ R6. R7 58 R1D0 ,10 R&amp;deg;, R , R - низша  алкильна  группа , или его фармацевтически приемлемой соли. Реагент 1: производное бензальдегида или его динизший алкилацеталь формулы ®с. сftb OR - низша  алкокси- или алканоилокси группа, кольцо A, R3, R -определены выше, Реагент 2: низший алкилацетилендикарбок- силат формулыQQ 1 IIII -, РОС-СнС-С-ОРГ R , R - указаны выше. Услови  реакции: 60-80&amp;deg;С в присутствии низшей тригалои- далкановой кислоты с использованием 1- 2 эквимол рного количества карбоксилата по отношению к бензальдегиду. 1 з.п.ф-лы. 4 табл. Поставленна  цель достигаетс  за счет способа получени  производного нафталина общей формулы: 9й «AS. е 00 CJ Ј VJ о (А

Cannabinoid derivatives

This disclosure relates generally to cannabinoid derivatives, pharmaceutical compositions comprising them, and methods of using the cannabinoid derivatives.

Method for producing hydroxyl-containing acetal compound

3,3-dimethylcyclohexane derivatives

The invention relates to 3,3-dimethylcyclohexane derivatives of the general structure (I), wherein the broken line, which binds the carbon atoms that are in the α- and β position in relation to the aldehyde group, represents a C-C single bond or a cis- or trans-configured C=C double bond. Said derivatives are characterized by interesting and original fragrance characteristics which diffuse extremely well and are suitable for use as perfumes, for example in cosmetic preparations, technical products or alcohol-based perfumery.

Polyvinyl ether compound and method of preperation

Acetylenic biaromatic compounds containing an adamantyl group; pharmaceutical and cosmetic compositions containing them and uses thereof

L'invention concerne de nouveaux composés bi-aromatiques acétylénés à groupement adamantyle qui présentent comme formule générale (I): <IMG> (I) ainsi que l'utilisation de ces derniers dans des compositions pharmaceutiques destinées à un usage en médecine humaine ou vétérinaire (affections dermatologiques, rhumatismales, respiratoires, cardiovasculaires et ophtalmologiques notamment), ou bien encore dans des compositions cosmétiques.

2,3-DIHYDROFURANNE DERIVATIVES, THEIR PREPARATION PROCESS, THEIR USE AS AN INTERMEDIATE FOR THE PREPARATION OF TETRAHYDROFURANNE

Method and intermediates for the synthesis of korupensamines

A method of preparing a korupensamine or an analog thereof comprising: (a) reacting a compound of formula (III), wherein each of R?1 and R2¿ is CH¿3? or H, X is I, Y is (C1-C4)alkyl, benzyl or CHO, and each of R?3 and R4¿ is (C¿1?-C4)alkyl, benzyl, (C2-C5)acyl or an acid-labile hydroxy protecting group; with a compound of formula (IV), wherein R?5¿ is benzyl, (C¿2?-C5)acyl or an acid-labile hydroxy protecting group, R?6¿ is B(OH)¿2?, and R?7¿ is (C¿1?-C4)alkyl; in the presence of a Pd(0) catalyst and an inorganic base in an organic solvent, to yield a compound of formula (V), wherein Y, R?1, R2, R3, R4, R5 and R7¿ are as defined above for compounds of formula (III) and (IV). Additionally the intermediates of formula (III), wherein X is Br, Cl or I, Y is H, (C¿1?-C4)alkyl, benzyl, or CHO, each of R?1 and R2 is H or CH3, R?3¿ is a protecting group selected from the group consisting of (C¿1?-C4)alkyl, benzyl, (C2-C5)acyl and an acid-labile hydroxy protecting group; and R?4¿ is H or (C¿2?-C5)acyl; or wherein X is Br, Cl or I, Y is H, (C1-C4)alkyl, benzyl, or CHO, each of R?1 and R2¿ is H or CH¿5, R?3 is H or (C¿2?-C5)acyl and R?4¿ is a protecting group selected from the group consisting of (C¿1?-C4)alkyl, benzyl, (C2-C5)acyl and an acid-labile hydroxy protecting group; and the intermediates of formula (IV), wherein R?6¿ is Cl, Br, I, B(OH)¿2?, an anhydride or ester of B(OH)2, or OSO2R?9¿, wherein R9 is (C¿1?-C4)perfluoroalkyl, and each of R?5 and R7¿ is H, (C¿1?-C4)alkyl, benzyl, (C2-C5)acyl or an acid-labile hydroxy protecting group.

Less salt method for preparing polysulfide

本发明涉及用于制备多硫化物的方法，该方法包括使双(2‑二卤代烷基)缩甲醛与(i)多硫化钠或(ii)氢硫化钠和硫的组合反应的步骤，所述反应在无二卤代烷烃存在下且在根据结构X‑(R 2 ‑O) n ‑CH 2 ‑O‑(R 1 ‑O) m ‑CH 2 ‑(O‑R 2 ) p ‑X的预聚物(I)存在下进行，其中R 1 和R 2 可以相同或不同，并且选自包含2‑10个碳原子的烷烃链，X是卤原子，n、m和p是可以相同或不同且具有1‑6的值的整数。

PROCEDURE FOR THE PREPARATION OF ALPHA-ARILALCANOIC ACIDS

Process for preparing alpha-phenyl- or -naphthyl-alkane-acid derivatives

Monomers containing at least one biaryl unit and polymers and derivatives prepared therefrom

The invention relates to bisphenol monomers containing one or more biaryl units and related polymers, derivatives and resins thereof and more particularly to Bisphenol monomers containing two biaryl units separated by a spacer group X, and to bisphenol monomers containing a biaryl unit and an aryl unit separated by a spacer group X, and to polymers, derivatives, resins and related products prepared therefrom.

PROCEDURE FOR THE PREPARATION OF AN AROMATIC GROUP OF ALFA-SUBSTITUTED ALCANCARBOXYLIC ACIDS OR ESTERS THEREOF, AND COMPOUNDS FOR USING THE PROCEDURE

Patent FR2205338B1