СПОСОБЫ ОЗОНОЛИЗА ОРГАНИЧЕСКИХ СОЕДИНЕНИЙ

Изобретение относится к способам озонолиза органических соединений. Способ производства озона, предназначенного для использования при озонолизе органических соединений, включает подачу жидкого кислорода в теплообменник и тем самым получение газообразного кислорода, подачу газообразного кислорода в генератор озона, подачу смеси озона и кислорода в установку отделения озона, подачу жидкого азота в теплообменник и тем самым получение газообразного азота, подачу газообразного азота в установку отделения озона и возвращение кислорода, отделенного от смеси озона и кислорода, в точку подачи газообразного кислорода, и подачу смеси озона и азота в реактор озонирования для озонолиза органических соединений. Изобретение обеспечивает безопасный и рентабельный озонолиз органических соединений. 3 н. и 18 з.п. ф-лы, 3 ил.

РЕАКЦИИ ОЗОНОЛИЗА В ЖИДКОМ CO2 И РАСТВОРИТЕЛЯХ, РАСШИРЕННЫХ CO2

FIELD: chemistry. SUBSTANCE: method for increasing ozone concentration in a liquid can include: providing a gas containing ozone; introducing the ozone-containing gas into a liquid, wherein the liquid and ozone combination is at temperature between about 0.8 and about 1.5 times the critical temperature of ozone; and increasing isothermally, the pressure of the ozone-containing gas above the liquid to about 0.3-5 times the critical pressure of ozone so as to increase ozone concentration in the liquid. The temperature is expressed in absolute units (Kelvin or Rankin). The method can be used to remove ozone from a gas or for purifying ozone. EFFECT: more efficient ozone purification. 37 cl, 27 dwg РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) 2 446 004 (13) C2 (51) МПК B01F 3/04 (2006.01) C01B 13/10 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ОПИСАНИЕ ИЗОБРЕТЕНИЯ К ПАТЕНТУ (21)(22) Заявка: 2010117591/05, 05.11.2008 (24) Дата начала отсчета срока действия патента: 05.11.2008 (73) Патентообладатель(и): ЮНИВЕРСИТИ ОФ КАНЗАС (US), АРЧЕР ДЭНИЕЛС МИДЛЕНД КОМПАНИ (US) (43) Дата публикации заявки: 20.12.2011 Бюл. № 35 2 4 4 6 0 0 4 (45) Опубликовано: 27.03.2012 Бюл. № 9 (56) Список документов, цитированных в отчете о поиске: US 2005274125 A1, 15.12.2005. US 2004033269 A1, 19.02.2004. US 2007062372 A1, 22.03.2007. US 7219677 B1, 22.05.2007. RU 2128168 C1, 27.03.1999. 2 4 4 6 0 0 4 R U (86) Заявка PCT: US 2008/082464 (05.11.2008) C 2 C 2 (85) Дата начала рассмотрения заявки PCT на национальной фазе: 07.06.2010 (87) Публикация заявки РСТ: WO 2009/061806 (14.05.2009) Адрес для переписки: 125009, Москва, а/я 332, ЗАО "Инэврика" (54) РЕАКЦИИ ОЗОНОЛИЗА В ЖИДКОМ CO2 И РАСТВОРИТЕЛЯХ, РАСШИРЕННЫХ CO2 (57) Реферат: Способ повышения концентрации озона в жидкости может включать обеспечение наличия газа, включающего озон; введение озонсодержащего газа в жидкость, причем комбинация жидкости и озона имеет температуру приблизительно от 0,8 до 1,5 критического значения температуры ...

Process for the treatment of lignin for obtaining aldehyde and/or phenolic acids

The invention relates to a process for the treatment of lignin with ozone for the selective preparation of aldehydes and/or phenolic acid. This process consists in bringing the lignin into contact with ozone using a liquid solvent bath based on 1,1,2,-trichloro-1,2,2-trifluoroethane; the formation of aldehydes and/or phenolic acids is observed without noticeable decomposition into small molecules; these components are isolated from the solvent and the solid residual lignin mainly by filtration and distillation. The yield is improved by using a liquid solvent bath in which alcohol and 1,1,2-trichloro-1,2,2-trifluoroethane are mixed in a very small ratio. The process can be applied in particular to lignin which is derived from vegetable material containing fibre, such as, for example, wood, bagasses, straw; these plant fibres are exploited and give a high-grade product. ...

VERFAHREN ZUR HERSTELLUNG VON MONO- ODER BISCARBONYLVERBINDUNGEN

2,2-DIFLUORCYCLOPROPYL-DERIVATE.

VERFAHREN ZUR KONTINUIERLICHEN OZONOLYSE VON OLEFINEN

14-Methyl-bi:cyclo-10,3,0-pentadecene-1,2-muscone precursor prepn. - by alkylating cyclo:dodecanone with allyl halide, ozonising cyclising, conversion to bi:cyclic alcohol, dehydration and opt. isomerisation

... 14-Me-bicyclo-(19,3,0)-pentadecene- 1(12) having formula (I) is prepd by (A) a phase transfer alkylotion reaction of cyclododecanone (II) with an allyl halide (III) (where X is Cl, Br, or I); (B) O3-dissociation of the 2-(2'-methylene-1'-propyl)-cyclododecanone (IV) obtd to form 2-(2'-oxo-1'-propyl)-cyclododecanone (V): (C) cyolisation of (V) to bicyclo (10,3,0)-pentadeca-15-en-14-one (VI); (D) reaction of (VI), opt after hydrogenation to bicyclo(10,3,0)-pentadecan-14-one, (VIa), with an MeMg halide, to form the new bicyclic alcohols (VII) or (VIIa); (E) dehydration of the alcohols to the new methylated bicyclic cpds. (VIII) or (VIIIa); (F) hydrogenation of the 14-Me-bicyclo (10.3,0)-pentadeca- 1(12).14 -diene (VIII) or G isomerisation of the 14-Me-bicyclo-(10,3,0)-pentadeca-14-ene (VIIIa) by heting with acids. (I) is an intermediate in muscone musk perfume prepn. and allows a simple prepn of muscone.

Reduction of metal oxides

In a process for the reduction of metal oxides (e.g. of iron or chromium) they are subjected in the fused condition to the action of a directionally stable plasma arc containing a hydrocarbon gas. The hydrocarbon gas may be methane which may also comprise the arc support gas but this latter may also be A, H2, He, N2, CO, Xe or Ne. In examples the iron oxide or chromium oxide content of a slag is reduced and the metal values descend through the slag into a pool of iron. Small amounts of lime, fluorspar or silica may be added to the slag to make it more fluid.

METHOD AND APPARATUS FOR THE PRODUCTION OF PEROXIDE DERIVATIVES OF HIGH-PURITY OZONIDES BY OZONIZATION OF THE CORRESPODNING OLEFINS AND SUBSEQUENT TREATMENTS

1382349 Gas/liquid contact SNIA VISCOSA SOC NAZIONALE INDUSTRIA APPLICAZIONI VISCOSA SpA 18 Feb 1972 [19 Feb 1971] 7719/72 Heading BIF [Also in Division C2] An apparatus suitable for conducting an olefin ozonolysis reaction comprises a reactor 10, Fig. 1, which is supplied with ozone from a generator 18 via a distributor 22, and with at least two types of solvent from reservoirs 36 and 38 through metering devices 32 and 34 respectively which reactor is provided with a bottom outlet 40 and a top outlet leading via duct 42 to condenser 44 and traps 48. Alternatively, Fig. 2, the reactor 110 may be connected at its lower outlet 140 to a pump 112 which sends the reaction product into a centrifuging device 114, from which a lighter phase is recycled to the reaction via conduit 116.

Supported ruthenium nanoparticle catalyst for CIS- dihydroxylation and oxidative cleavage of alkenes

The present invention relates to the use of nanosized metal particles (e.g., ruthenium) grafted on inert solid support for oxidation of alkenes. The supported metal catalyst can effect cis-dihydroxylation and oxidative cleavage of alkenes to give the respective cis-diols and carbonyl products.

Metering method for particulate material

VERFAHREN ZUR HERSTELLUNG VON GLYOXAL, ALKYLGLYOXALEN UND VON DEREN ACETALEN

VERFAHREN ZUR REINIGUNG VON O-PHTHALDIALDEHYD

PROCEDURE FOR THE CLEANING OF O-PHTHALDIALDEHYD

PROCEDURE FOR THE PRODUCTION OF MONO OR BISCARBONYLVERBINDUNGEN

HYDROGENOLYTI REDUCTION PEROXIDI OZONOLYSEPRODUKTE AND DEVICE TO YOUR EXECUTION

ARYL FLUORINE ALKENE AMIDES AND YOUR USE AS PESTICIDES.

PROCEDURE FOR THE CLEANING OF O-PHTHALDIALDEHYD

OXIDATIVE SPLITTING OF INSATIATED ONES OF OILS AS WELL AS FROM IT MANUFACTURED PRODUCTS

CYCLOPROPANE COMPOUNDS

PREPARATION OF CARBONYL COMPOUNDS

PREPARING ESTERS OF 3-METHYLFLAVONE-8-CARBOXYLIC ACID WITH AMINOALCOHOLS

INTERMEDIATE IN THE PREPARATION OF CYCLOPROPYLCARBOXYLATE ESTERS AND PROCESS FOR ITS MANUFACTURE

INTERMEDIATES IN THE PREPARATION OF CYCLOPROPYLCARBOXYLATE ESTERS AND PROCESS FOR THEIR MANUFACTURE

INTERMEDIATE IN THE PREPARATION OF CYCLOPROPYLCARBOXYLATE ESTERS AND PROCESS FOR ITS MANUFACTURE

ABSTRACT NOVEL INTERMEDIATE IN THE PREPARATION OF CYCLOPROPYL-CARBOXYLATE ESTERS AND PROCESS FOR ITS MANUFACTURE 3-Hydroxymethyl-2,2-dimethylcyclopropanecarbaldehyde dimethyl acetal, especially in the same stereoisomeric form as that of the cyclopropane ring in (+)-3-carene, is a novel intermediate useful in the manufacture of pyrethroid insecticides. It may be manufactured by a process characterised in that 3-acetoxymethyl-2,2-dimethylcyclo-propane carbaldehyde dimethyl acetal is subjected to hydrolysis.

METHOD FOR PREPARING 3-ETHYLBENZOPHENONE

ABSTRACT OF THE DISCLOSURE The present invention provides a method for preparing 3-ethylbenzophenone in a high purity which comprises the steps of alkylating benzene with ethylene with the aid of an alkylating catalyst to obtain an alkylated product composed mainly of unreacted benzene, ethylbenzene, polyethylbenzenes and heavier by-products; subjecting the alkylated product to distillation in order to recover therefrom a fraction which has a temperature range of boiling points within the range of 275 to 310°C (in terms of atmospheric pressure); dehydro-genating the recovered fraction at a reaction temperature within the range of 200 to 700°C in the presence of a dehydrogenating catalyst; oxidizing the dehydrogenated fraction in a liquid phase; and performing distillation to recover therefrom 3-ethylbenzophenone represented by the formula:

INTERMEDIATE IN THE PREPARATION OF CYCLOPROPYLCARBOXYLATE ESTERS AND PROCESS FOR ITS MANUFACTURE

... "NOVEL INTERMEDIATE IN THE PREPARATION OF CYCLOPROPYLCARBOXYLATE ESTERS AND PROCESS FOR ITS MANUFACTURE" 3-Acetoxymethyl-2,2-dimethylcyclopropanecarbaldehyde dimethyl acetal, especially in the same stereoisomeric form as that of the cyclopropane ring in (+)-3-carene, is a novel intermediate useful in the manufacture of pyrethroid insecticides. It may be manufactured by a process characterised in that 2-(3-acetoxy-methyl-2,2-dimethylcyclopropyl)vinyl acetate is subjected to ozonolyis and the ozonolysis product so formed is subjected to reduction in the presence of methanol and an acetalizing catalyst.

ALDOL DERIVATIVES AND PRODUCTION THEREOF

ABSTRACT OF THE DISCLOSURE Novel aldol derivatives of the formula,

NOVEL RESINS BEARING A CHIRAL AUXILIARY FOR THE CONSTRUCTION OF SMALL CHIRAL ORGANIC MOLECULES

The present invention relates to resins bearing a chiral auxiliary wherein the chiral auxiliary can be either a cycloalkanone or heterocycloalkanone comprising at least one chiral atom. At least one of the chiral atoms is located alpha to the carbonyl functionality of the cycloalkanone or heterocycloalkanone. The chiral atom located alpha to the carbonyl functionality is linked to a polymer support using a linker.

PREPARATION OF A CYCLOPROPANECARBALDEHYDE

GUERBET ALCOHOLS AND METHODS FOR PREPARING AND USING SAME

The invention relates to Guerbet alcohol precursors and Guerbet alcohols, as well as to processes for synthesizing them.

OZONOLYSIS OPERATIONS FOR GENERATION OF REDUCED AND/OR OXIDIZED PRODUCT STREAMS

The present invention relates to methods for safe and efficient use of hydrogen and oxygen in ozonolysis operations. The invention also relates to an ozonolysis process involving elements of both reductive and oxidative ozonolysis which are integrated in a continuous process. In one embodiment, the ozonolysis process of the present invention uses hydrogen and/or oxygen generated from water and electricity, which may be recycled to generate water and/or electricity.

Procédé pour la préparation d'un mélange d'acides et d'aldéhydes en partant d'hydrocarbures non saturés.

Procédé d'obtention de produits d'oxydation des hydrocarbures basé sur l'emploi de l'ozone agissant comme catalyseur d'oxydation.

Flowery scenting dodeca-4,8-diene-1,12 dialdehyde prodn. - by ozonolysis of cyclododeca-1,5,9-triene followed by reduction of ozonide

Dodeca-4,8-diene-1,12-dialdehyde is produced by ozonolysis of cyclododeca-1,5,9-triene, and then reducing the resulting ozonide, pref. in an inert organic solvent, esp. a mixt. of acetic acid and petroleum ether. The reduction of the ozonide is pref. carried out with zinc in the presence of acetic acid. When cyclodedeca-1 trans, 5 trans, 9 trans-triene is used as a starting material, dodeca-4 trans, 8 trans-diene-1,12-dialdehyde is obtd; from the 1 trans, 5 trans, 9 cis-stereoisomer the 4 trans, 8 cis-product is obtd., and from 1 cis, 5 cis, 9 cis-stereoisomer the 4 cis, 8 cis-product. The first and the third of these isomers are new cpds. These cpds. have flowery scent and can be used in perfumes, cosmetics, foodstuffs, drinks, pharmaceuticals etc.

Preparation of carbonyl cpds

Method for prepn. of carbonyl cpds. (R1, R2 & R3 = sec. amine residues, pref. from di-(1-7C)-alkylamines or heterocyclic amines). (a) The redn. proceeds at low temp., (b) high yield and the carbonyl group does not reduce further, (c) excess phosphine is readily removed by acid washing and (d) no additional solvent is required.

Verfahren zur Herstellung von makrocyclischen Ketonen

Procédé pour la préparation d'un dérivé furannique

Verfahren zur Herstellung von a-Oxo-a, B-seco-steroid-B(y)-inen

Flowery scenting dodeca-4,8-diene-1,12 dialdehyde - used in perfumes cosmetics, foodstuffs, drinks, phaarmaceouticals etc.

Perfume or aroma compsns. contain dodeca-4,8-diene-1, 12-dialdehyde having formula OHC-(CH2)2-CH=CH-(CH2)2-CH=CH-(CH2)2-CHO. This cpds. is normally used in the form of a mixt. of its stereoisomers; the 4-trans-8-trans and 4-vis-8-cis stereoisomers being new cpds. These cpds. can be produced by ozonolysis of cyclododeca-1,5,9-triene and reduction of the resulting ozonide. These cpds. can be used for developing or modifying aroma of the flowing scenting agents of the aldehyde series. Thus, dodeca-4-trans, 8-cis-diene-1,12-dialdehyde has a scent similar to coriander or calamus. These cpds. can be incorporated into perfumes, soaps, cosmetics, air-purifying compsns, food-stuffs, drinks, pharmaceuticals, tobacco, etc., in an amt.

Verfahren zur Herstellung von Secosteroiden

Verfahren zur Oxydation eines gesättigten Kohlenwasserstoffs der aliphatischen oder cycloaliphatischen Reihe zu einem Alkohol und Keton enthaltenden Produkt

Verfahren zur Herstellung des 7-Methylen-bicyclo(3.3.1)nonan-3-on

Verfahren zur Herstellung von Aldehyden

Verfahren zur Herstellung von Acetylenverbindungen

Verfahren zur Herstellung von 4,5-disubstituierten 3-Hydroxycyclopentanonen

Verfahren zur Herstellung von Terpenderivaten

Verfahren zur Herstellung von Terpenderivaten

Verfahren zur Herstellung von Acetylenverbindungen

Verfahren zur Herstellung von Terpenderivaten

Procédé pour la préparation de dérivés furanniques

Use of cis-6-octen-1-al as perfuming ingredient

Use of a novel unsaturated aldehyde, cis-6-octen-1-al, as a perfuming ingredient. This product adds a fruity olfactory note, and is suitable, in particular, for the preparation of odoriferous compositions intended for cosmetic products.

Mono: and bis:hydroxy-methyl phenol derivs.

Prodn. of new salicyl alcohol derivs. of formula (I) comprises hydroxymethylation of cpds. of formula (II):- In the formula, R1=H or CH3. R2 = 5-8C alkyl or -CH2CH2-p-C6H4-Z. Z = H, F OR Cl. m = 5 or 6. X' = H or CH2OH. The cpds. with different values or R4 are then sepd. and opt. (where X' = COOH), converted into salts with (in)organic bases. Cpds. with X'=COOH can also be esterified to X'=COR3 (R3=lower alkoxy) or converted to quaternary ammonium salts. (I) have uterus-stimulating (viz abortion-, labour- or menstruation-inducing) and hypotensive activities. The usual dose for large mammals is 10-500 mg/day.

5-Substd. 4-hydroxyalkyl-salicylaldehyde derivs. prepn.

New salicylaldehyde derivs. of formula (I):- (where R1 is H or Me; R2 is 5-8C alkyl or p-Z-phenethyl; Z is H, F or Cl; m = 5 or 6; X is 1H-tetrazol-5-yl or COOH) are prepd. by oxidising the corresp. hydroxymethyl deriv. of formula (II).Cpds. (I) (X = COOH) can be converted into salts by treatment with an (in)organic base, or esterified to form lower alkyl esters.(I) are uterine stimulants (e.g. for inducing labour or menstruation or for terminating pregnancy) and hypotensives. In an example, dl-5-(6-carboxyhexyl)-4-(3-hydroxyoctyl)-salicylaldehyde is prepd. from dl-4-(6-carboxyhexyl)-2-hydroxymethyl-5-(3-hydroxyoctyl)-phenol.

3-Hydroxy-alkyl-4-carboxy-alkyl-phenol derivs. prepn.

Prodn. of new phenol derivs. of formula (I):- comprises demethylation of the corresp. ethers (I: HO- is CH3O-) then opt. converting (I) (where X'=COOH), to a salt with.Cpds. with X' =COOH can also be esterified to give cpds. with X=COR3 (R3=alkoxy), or converted to quaternary ammonium salts. In the formula, R1 is H or CH3. R2 is 5-8C alkyl or -(CH2)2-p-C6H4-Z. Z is H, F or Cl. m is 5 or 6. X' is COOH or 1H-tetrazol-5-yl.(I) have uterus-stimulating (abortion-, labour- or menstruation-inducing) and hypotensive activities. The usual dose for large mammals is 10-500 mg/day. (I) is e.g. d, 1-4-(6'-carboxyhexyl)-3-(3'-hydroxyoctyl)phenol.

UNSATURATED ALICYCLIC COMPOUNDS, THEIR USE AS SCENTING INGREDIENTS AND PROCESS FOR THEIR PREPARATION.

Carboxyalkyl- or tetrazolyl:alkyl-hydroxyalkyl-methoxy-benzene derivs.

In a process for the prodn. of new methoxybenzene derivs. of formula (I): (where R1 is H or CH3; R2 is 5-8C alkyl or p-Z-phenethyl (Z=H, F or Cl); m is 5 or 6; and Z is COOH or 1H-tetrazol-5-yl), an aldehyde of formula (II) is reacted with a phosphonium salt of the formula Ph3P+-(CH2)m-1X'Y- (III) (where Y is Cl, Br or I) and the prod. is hydrogenated. (I; X'= COOH) may be esterified to give their lower alkyl esters, or converted into acceptable salts by treatment with org. or inorganic bases.(I) have uterine-stimulant and hypotensive activity. (I) have a uterotonic activity in vitro at a concn. of 1-10 mg/l and on the uterus in situ at doses of 40-2000 ug/kg. (I) are partic. suitable for the treatment of essential hypertension, for inducing labour, for eliminating a retained foetus, for terminating pregnancy and for inducing menstruation. Dosage for larger mammals is 10-500 mg/day.Specific cpds. (I) include DL-1-(6-carboxyhexyl)-2-(3-hydroxyoctyl)-4-methoxybenzene. In an example, this ...

Carboxyalkyl- or tetrazolyl:alkyl-hydroxyalkyl-cyclohexenone derivs.

In a process for the prodn. of new cyclohexenone derivs. of formula (I): (where R1 is H or CH3; R2 is 5-8C alkyl or p-Z-phenethyl (Z=H, F or Cl); m is 5 or 6; and Z is 1H-tetrazol-5-yl or a group -COR3 in which R3 is OH, lower alkoxy or amino), a methoxybenzene deriv. of formula (II) is reduced and (I; X=COOH) thus obtained is opt. converted into an acceptable salt by treatment with an inorganic organic base. (I) obtd. as above may be isomerised to give cpds. of formula (Ia): (I) and (Ia) have u terine-stimulant and hypotensive activity. They have a uterotonic effect in vitro at a concn. of 1-10 mg/l and on the uterus in situ at doses of 40-2000 mu g/kg. (I) and (Ia) are partic. suitable for the treatment of essential hypertension, for inducing labour, for eliminating a retained foetus, for terminating pregnancy, and for inducing menstruation. Dosage for larger mammals is 10-500 mg/day.Specific cpds. (I) include dl-4-(6-carboxyhexyl)-3-(3-hydroxyoctyl)-3-cyclohexen-1-one. In an example, ...

4-ACETYL-2-ALKOXY-7,7-DIMETHYL-3-OXABICYCLO (4.1.0) HEPTANE AND PROCEDURE FOR THEIR PRODUCTION.

PROCEDURE FOR THE PRODUCTION OF A ACETYL BICYCLOHEXENS.

Cyclopropylacetic acid, its derivatives and their preparation

PROCEDURE FOR THE PRODUCTION OF SUBSTITUTED CYCLOPROPANCARBALDEHYDEN.

CYCLOPROPANCARBONSAEUREESTERDERIVATE.

АРИЛПИПЕРАЗИНЫ, ИМЕЮЩИЕ АКТИВНОСТЬ В ОТНОШЕНИИ 1 А РЕЦЕПТОРА СЕРОТОНИНА

... 1. Соединение формулы где Ar′ представляет собой моно- или бициклический арильный или гетероарильный радикал, замещенный от одного до трех заместителями, выбранными из группы, состоящей из водорода, (C1-C6)алкила, (C1-C6)алкокси, (C1-C6)алкилтио, (C2-C6)алкенила, (C2-C6)алкинила, (C2-C6)алкилгалоида, (C3-C8)циклоалкила, (C3-C8 )циклоалкенила или галоида; R1представляет собой водород, (C1-C6)алкил, (C1-C6)алкокси, (C1-C6)алкилтио; R2 представляет собой фенил, нафтил или (C3-C12)циклоалкил, замещенный одним или двумя заместителями, выбранными из группы, состоящей из водорода, (C1-C6)алкила, (C1-C6)алкокси, (C1-C6)алкилтио, (C2-C6)алкенила, (C2-C6)алкинила, (C1-C6)алкилгалоида, (C3-C8)циклоалкила, (C3-C8 )циклоалкенила или галоида; R3выбирают из группы, состоящей из водорода, (C1-C6)алкила, (C1-C6)алкокси, (C1-C6)алкилтио, (C2-C6 )алкенила, (C2-C6)алкинила, (C1-C6)алкилгалоида, (C3-C8)циклоалкила, (C3-C8)циклоалкенила или галоида; X означает -C(=O)-, -CHOH- или -CH2-; или его фармацевтически ...

ARYLPIPERAZINES HAVING ACTIVITY TO SETOTONIN 1 RECEPTORS

SUBSTITUTED CYCLOPENTANONES

METHOD FOR THE PRODUCTION OF ALDEHYDIC ACIDS

METHOD FOR PREPARING DIALDEHYDES SATURATE AND UNSATURATES

Dérivés de cyclopropane et application de certains de ces dérivés comme pesticide.

DERIVES DE CYCLOPROPANE. DERIVES DE CYCLOPROPANE DE FORMULE: (CF DESSIN DANS BOPI) DANS LAQUELLE R REPRESENTE UN GROUPE ACETYLE OU ACETOXY; UN GROUPE ALCOXY CONTENANT DE 2 A 10ATOMES DE CARBONE EVENTUELLEMENT SUBSTITUE PAR UN OU PLUSIEURS ATOMES D'HALOGENE; UN GROUPE (CYCLOALCOYL)ALCOXY CONTENANT DE 3 A 7ATOMES DE CARBONE DANS LE CYCLE; UN GROUPE ALCENYLOXY CONTENANT DE 2 A 4ATOMES DE CARBONE EVENTUELLEMENT SUBSTITUE PAR UN OU PLUSIEURS ATOMES D'HALOGENES; UN GROUPE ALCYNYLOXY CONTENANT DE 2 A 4ATOMES DE CARBONE; UN GROUPE ARYLOXY CONTENANT DE 6 A 12ATOMES DE CARBONE; UN GROUPE ARALCOYLOXY CONTENANT DE 7 A 10ATOMES DE CARBONE; ET X EST -CHCH(OCH); -CHCHO; -CHCHOR OU R EST UN GROUPE ACYLE CONTENANT DE 2 A 5ATOMES DE CARBONE; -CHO; -COCL; -COBR; COOR OU R REPRESENTE UN ATOME D'HYDROGENE, UN CATION FORMANT DES SELS, UN GROUPE ALCOYLE CONTENANT DE 1 A 20ATOMES DE CARBONE; OU UN GROUPE PHENOXYBENZYLE OU ALPHACYANO-PHENOXY-BENZYLE; AVEC LA CONDITION QUE QUAND R EST UN GROUPE ACETOXY, X NE DOIT ...

METHOD OF PREPARATION Of ACIDS PERFLUOROCARBOXYLIQUES

PROCESS Of CATALYTIC OXIDATION OF TOLUENE IN GAS PHASE USING a GAS CONTAINING OF MOLECULAR OXYGEN

L'invention concerne un procédé d'oxydation catalytique de toluène en phase gazeuse à l'aide d'un gaz contenant de l'oxygène moléculaire. On effectue l'oxydation en présence d'une masse de catalyseur qui comporte du vanadate d'argent et du vanadate de fer, et de préférence en outre un vanadate d'un ou plusieurs métaux de terres rares. Dans le procédé selon l'invention une activité catalytique augmentée se combine avec une sélectivité bonne. L'invention peut être appliquée à la préparation du benzaldéhyde et/ou de l'acide benzoïque. The invention relates to a process for the catalytic oxidation of toluene in the gas phase using a gas containing molecular oxygen. The oxidation is carried out in the presence of a catalyst mass which comprises silver vanadate and iron vanadate, and more preferably a vanadate of one or more rare earth metals. In the process according to the invention, an increased catalytic activity combines with a good selectivity. The invention can be applied to the preparation of benzaldehyde and / or benzoic acid.

PREPARATION Of a CYCLOPROPANECARBALDEHYDE

산화 반응 장치, 및 산화물의 제조 방법

... 탄화수소를 반응적으로도 에너지적으로도 효율적으로 산화시킬 수 있는 산화 반응 장치를 제공한다. 본 발명의 산화 반응 장치는, 반응 기질로서의 탄화수소를 함유하는 액체가 도입되는 액체 도입 유로와, 산소와 오존을 포함하는 기체가 도입되는 기체 도입 유로와, 상기 액체 도입 유로로부터 도입된 액체와 상기 기체 도입 유로로부터 도입된 기체를 혼합하는 기액 혼합부와, 산화 촉매가 고정 또는 충전된 유동 반응기를 구비한 산화 반응 장치로서, 상기 유동 반응기가, 모놀리스형 담체와 해당 모놀리스형 담체에 고정 또는 충전된 산화 촉매로 구성되어 있는 것, 및/또는 상기 기액 혼합부가 마이크로버블 발생 장치인 것을 특징으로 한다.

PROCESS FOR THE PREPARATION OF METHOXYMELONAL

A process of forming methoxymelonal comprising the steps of treating a solution of citronellene to ozonolysis, and hydrogenating the product formed to provide methoxymelonal.

METHOD AND APPARATUS FOR THE PREPARATION OF ALDEHYDES

A method and an apparatus for producing aromatic aldehydes, including benzaldehyde and metatolualdehyde. Raw materials and a source of oxygen are fed into a tube reactor. The raw materials may be in a liquid or vapor phase. The reaction to form the aldehyde is catalyzed by suitable solid or liquid catalysts, including copper containing catalysts.

Sandalwood odorants

The present invention relates to novel substituted cyclohexanol compounds possessing a sandalwood aroma which are useful as fragrance materials. The invention also provides methods for synthesis thereof through a novel aldehyde intermediate. The compounds of the invention have the formula: см. иллюстрацию в PDF-документе wherein A is см. иллюстрацию в PDF-документе and wherein R1 is methyl or ethyl, R2 -R7 are independently hydrogen or methyl with the proviso that a maximum of two of the substituents R2 -R7 are methyl, and R8 is hydrogen, lower alkyl (C1 to C5) or acyl. The invention also provides fragrance compositions which utilize the compounds of the invention to impart a sandalwood aroma to perfume compositions, colognes and perfumed articles.

PROCESS FOR PREPARATION OF TERPENE FLAVORANTS

A process for preparing sinensal by the ozonization of beta farnesene and reduction of the ozonolysis product to obtain sinensal, which is suitable as a flavor-inparting agent of orange aroma.

Oxygen-containing aliphatic compounds and their use as intermediates for the preparation of 4-hydroxy-2, 5-dimethyl-3(2H)-furanone

PCT No. PCT/IB94/00261 Sec. 371 Date Apr. 13, 1995 Sec. 102(e) Date Apr. 13, 1995 PCT Filed Sep. 1, 1994 PCT Pub. No. WO95/07876 PCT Pub. Date Mar. 23, 1995The compounds of the invention are characterised by the formulae (II) and (III) wherein index p represents an integer equal to 2 or 3 and q can take the value zero or 1, with the provision that p+q=3. Said compounds are obtained from hex-3-yne-2,5-diol following a process which comprises reacting an ethylenic compound of formula(CH3)2C=C(H)n(CH3)m(I)wherein index n represents an integer equal to 1 or 2 and m can take the values zero or 1 and wherein n+m=2, with hex-3-yne-2,5-diol, followed by the oxidation of the acetylenic ether obtained by means of ruthenium tetroxide. The compounds of formula (III) can be used as intermediate products for the preparation of 4-hydroxy-2,5-dimethyl-3(2H)-furanone (Furaneol TM ).

Film ozonolysis in a tubular or multitubular reactor

The disclosure relates to a method of performing ozonolysis or ozone-based oxidation on a liquid or emulsified reagent using a tubular falling firm reactor with one or multiple tubes wherein the combined ozone and carrier gas flow is co-current.

Arylpiperazines having activity at the serotonin 1a receptor

A series of aryl piperazine compounds are effective pharmaceuticals for the treatment of conditions related to or affected by the serotonin 1A receptor; the compounds are particularly effective antagonists at that receptor, and are particularly useful for alleviating the symptoms of nicotine and tobacco withdrawal. The compounds are of the formula wherein Ar' is a mono or bicyclic aryl or heteroaryl radical substituted with one to three substituents selected from the group consisting of hydrogen, (C1-C6)alkyl, (C1-C6)alkoxy, (C1-C6)alkylthio, (C2-C6)alkenyl, (C2-C6)alkynyl, (C1-C6)alkylhalo, (C3-C8)cycloalkyl, (C3-C8)cycloalkenyl or halo; R1 is hydrogen, (C1-C6)alkyl, (C1-C6)alkoxy, (C1-C6)alkylthio; R2 is phenyl, naphthyl or (C3-C12)cycloalkyl substituted with one or two substituents selected from the group consisting of hydrogen (C1-C6)alkyl, (C1-C6)alkoxy, (C1-C6)alkylthio, (C2-C6)alkenyl, (C2-C6)alkynyl, (C1-C6)alkylhalo, (C3-C8)cycloalkyl, (C3-C8)cycloalkenyl or halo; R3 is selected ...

METHOD FOR PRODUCING HEXAFLUOROACETONE OR HYDRATE THEREOF

Hexafluoroacetone or a hydrate thereof is produced with a high yield by subjecting a 1-fluoro-4,4-bis(trifluoromethyl)-2,3,5-trioxolanyl ether compound represented by the general formula: wherein R is an alkyl group having 1 to 8 carbon atoms, an aryl group, or a benzyl group, which has been obtained by ozone oxidation of a heptafluoroisobutenyl ether compound, to a reduction reaction in the presence of a reducing agent selected from dialkyl sulfide containing an alkyl group having 3 or 4 carbon atoms, diaryl sulfide, diaryl disulfide, and diaralkyl sulfide.

СПОСОБЫ СИНТЕЗА ИНГЕНОЛА И ЕГО ПРОМЕЖУТОЧНЫХ СОЕДИНЕНИЙ

СПОСОБЫ ОЗОНОЛИЗА ОРГАНИЧЕСКИХ СОЕДИНЕНИЙ

1. Способ производства озона, предназначенного для использования при озонолизе органических соединений, включающий следующие стадии:а) подача жидкого кислорода в теплообменник и, тем самым, получение газообразного кислорода;b) подача газообразного кислорода в генератор озона;с) подача смеси озона и кислорода в установку отделения озона;d) подача жидкого азота в теплообменник и, тем самым, получение газообразного азота и подача указанного газообразного азота в указанную установку отделения озона; ие) возвращение кислорода, отделенного от указанной смеси озона и кислорода, в точку подачи газообразного кислорода, и подача смеси озона и азота в реактор озонирования.2. Способ по п. 1, в котором указанные органические соединения подобраны из группы, состоящей из алкенов, алкинов, бензиловых эфиров и олеиновой кислоты.3. Способ по п. 1, в котором указанная установка отделения озона представляет собой кислородно-озонную систему адсорбции со сдвигом давления.4. Способ по п. 3, в котором в указанной системе адсорбции со сдвигом давления имеется адсорбент, подобранный из группы, состоящей из силикагеля и цеолитных адсорбентов с высоким содержанием оксида кремния.5. Способ по п. 3, в котором указанная установка отделения озона представляет собой систему мембранного разделения.6. Способ по п. 1, дополнительно включающий подачу указанного газообразного азота в указанный реактор озонирования.7. Способ производства озона, предназначенного для использования при озонолизе органических соединений, включающий следующие стадии:а) подача жидкого кислорода в теплообменник и, тем самым, получение газообразного кислорода;b) подача газоо РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 2014 104 252 A (51) МПК B01D 53/22 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ЗАЯВКА НА ИЗОБРЕТЕНИЕ (21)(22) Заявка: 2014104252/05, 03.07.2012 (71) Заявитель(и): ЛИНДЕ АКЦИЕНГЕЗЕЛЛЬШАФТ (DE) Приоритет(ы): (30) Конвенционный приоритет: (72) Автор(ы): ФИТЧ Фрэнк Р. (US), САЧЕК Нареш Дж. (US) 07.07 ...

РЕАКЦИИ ОЗОНОЛИЗА В ЖИДКОМ CO2 И РАСТВОРИТЕЛЯХ, РАСШИРЕННЫХ CO2

... 1. Способ повышения концентрации озона в жидкости, содержащий: ! обеспечение наличия газа, включающего озон; ! введение озонсодержащего газа в жидкость, причем комбинация жидкости и озона имеет температуру приблизительно от 0,8 до 1,5 критического значения температуры озона; ! изотермическое повышение давления озона в жидкости приблизительно до 0,3-5 критических значений давления озона, чтобы повысить концентрацию озона в жидкости. ! 2. Способ по п.1, в котором температура составляет приблизительно от 1 до 1,2 критического значения температуры озона, причем температура выражена в абсолютных единицах (по шкале Кельвина или шкале Ренкина). ! 3. Способ по п.1, в котором давление повышают до приблизительно 0,5-2 критического значения давления озона. ! 4. Способ по п.1, в котором концентрацию озона в жидкости повышают по меньшей мере приблизительно в 5 раз. ! 5. Способ по п.1, дополнительно содержащий обеспечение ультразвукового перемешивания жидкости и озона. ! 6. Способ по п.1, в котором концентрацию ...

Verfahren zur Herstellung von 2,5-Dimethyl-4,5-dihydrofuranol-(3)-on-(4)

Verfahren zur Herstellung spezieller aromatischer Aldehyde

Bereitgestellt wird ein neues Verfahren zur Herstellung spezieller aromatischer Aldehyde durch Ozonolyse aromatischer Alkene. Dieses neue Verfahren läßt sich vorteilhaft in eine Synthese spezieller chiraler Diole unter Einsatz derartiger aromatischer Aldehyde integrieren.

Methylbutene dial 1-acetals prepn. - from crotonaldehyde, acetals useful as inters for carotenoids

Process for prepg. trans-3-methyl-2-butene-1,4-diol-1-acetals of formula (I) comprises (a) ozonolysis of crotonaldehyde acetals (II) in an org. solvent at 0 degree C then reductive elimination to give glyoxal monoacetals which (b) are vinylated in a Grignard reaction then acetylated to give cpds. (III), then (c) (III) are hydroformylated using conventional Rh catalysts at 60-140 degrees C and 20-1500 atm. excess, with CO and H2 and (d) the prod. is subjected to conventional elimination of acetic acid. (R1 and r2 = 1-4C aliphatic hydrocarbyl or together form ethylene or propylene, opt. substd. by 1-4C alkyl, pref. CH3). (I) are inters. in synthesis of carotenoids e.g. reaction with the ylid from beta-ionylideneethyltriphenylphos-phonium salts and subsequent hydrolysis, gives retinal. Process provides (I) in relatively few stages.

New alicyclic ketones their use and process for preparing same

Novel compounds of formula wherein each of the symbols R<1>, R<2>, R<3> and R<4> represents a hydrogen atom or a methyl group, and R<5> a linear or branched alkyl radical having 1 to 3 carbon atoms may be prepared by reacting an alicyclic ketone of formula wherein the symbols R<3>, R<4> and R<5> have the same meaning as given for formula (I) with a compound of formula wherein the symbols R<1> and R<2> have the same meaning as given for formula (I) and X represents a halogen atom, in the presence of a strong base and an inert organic solvent, and subsequently hydrolyzing the thus obtained reaction product. The compounds of formula I may be used for modifying, enhancing or improving the odoriferous properties of perfumes or perfumed products.

OXA BICYCLOHEPTANE DERIVATIVES

CYCLOALKANE DERIVATIVES

PROCESS FOR THE PRODUCTION OF SUBSTITUTED BENZALDEHYDES AND AND INTERMEDIATES THEREFOR

PROCEDURE FOR THE MODIFICATION OF CASHEW NUTSHELL OIL

Procedure for the production of 7-Methylen-bicyclo [3.3.1] nonan-3-on

PROCEDURE FOR THE REPRESENTATION OF KETONEN BY OZONOLYSE

PROCEDURE FOR THE PRODUCTION OF MONO OR BISCARBONYLVERBINDUNGEN

Method for Producing Oxygen-Containing Compound

[Problem] There is provided a method for producing an oxygen-containing compound safely and with improved reaction efficiency, in which an undesired peroxide is unlikely to be produced, and efficient heat exchange of the ozonization can be achieved. [Mean for solving the Problem] The method comprises an ozonization reaction step of continuously supplying, together with an organic compound, ozone having an oxygen content of less than 10% in a dissolved state in high-pressure carbon dioxide to an ozonization reaction section having a thin tubular shape, and reacting the ozone and the organic compound under conditions that suppress generation of oxygen due to thermal decomposition of the ozone, thereby continuously producing an ozonide; and a decomposition reaction step of continuously supplying the ozonide produced in the ozonization reaction step to a decomposition reaction section having a thin tubular shape, thereby continuously producing an oxygen-containing compound, the decomposition reaction step being provided in a manner continuous with the ozonization reaction step.

Guerbet Alcohols and Methods for Preparing and Using Same

The invention relates to Guerbet alcohol precursors and Guerbet alcohols, as well as to processes for synthesizing them.

Ozonolysis Operations for Generation of Reduced and/or Oxidized Product Streams

The present invention relates to methods for safe and efficient use of hydrogen and oxygen in ozonolysis operations. The invention also relates to an ozonolysis process involving elements of both reductive and oxidative ozonolysis which are integrated in a continuous process. In one embodiment, the ozonolysis process of the present invention uses hydrogen and/or oxygen generated from water and electricity, which may be recycled to generate water and/or electricity. 1. An ozonolysis process for generation of linear alkyl aldehydes and diacids or acid esters using elements of both the reductive and oxidative ozonolysis of a fatty acid or a fatty acid ester , wherein the reductive and the oxidative steps are integrated in a continuous process.2. A method comprising:a) providing oxygen and hydrogen, wherein said oxygen is utilized as a reagent for generating ozone; wherein said ozone is used in ozonolysis of a fatty acid or a fatty acid ester in an ozone reactor;b) inputting said fatty acid or fatty acid ester into said ozone reactor, in which said fatty acid or fatty acid ester absorbs said ozone, thereby forming a mixture comprising ozonated product stream comprising one or more compounds selected from ozonide, peroxide, aldehyde, ester, and acid; and i. partially reducing said ozonated product stream after said ozonated product stream enters a hydrogenation chamber to generate partially reduced products comprising largely a linear aldehyde, wherein said linear aldehyde, when in the presence of water, forms two layers comprising an organic phase while leaving the hydrogenation chamber;', 'j. fractionating said organic phase to separate said linear alkyl aldehyde from the remaining organic phase; and', 'k. oxidizing the remaining organic phase after fractionation at step (j) after the remaining organic phase enters into an oxidation chamber, resulting in the generation of said oxygenated products comprising said diacid or acid-ester;', 'thereby generating said linear ...

Ozonized biochar compositions and methods of making and using the same

Ozonized biochar compositions and methods for creating advanced hydrophilic biochar materials are provided with higher cation exchange capacity, optimized pH, improved wettability, and free of potential toxic components. These ozonized biochar compositions are used as filtration materials, as biochar soil additives and as carbon sequestration agents to help control climate change for energy and environmental sustainability on Earth.

FILM OZONOLYSIS IN A TUBULAR OR MULTITUBULAR REACTOR

The disclosure relates to a method of performing ozonolysis or ozone-based oxidation on a liquid or emulsified reagent using a tubular falling firm reactor with one or multiple tubes wherein the combined ozone and carrier gas flow is co-current. 162.-. (canceled)63. A method of performing ozonolysis or ozone-based oxidation on a liquid or emulsified reagent using an industrial scale tubular falling film reactor with one or multiple tubes wherein the combined ozone and carrier gas flow is co-current , and wherein the ozonolysis occurs continuously without accumulation of large amounts of hazardous intermediates , and wherein the tubes are cooled by flow of a coolant.64. The method of claim 63 , wherein the diameter of the tube(s) is between 5 mm and 5 m claim 63 , and the feeding pressure of the gaseous reagent is between 0.1 and 5 bar.65. The method of claim 63 , wherein the diameter of the tube(s) is between 5 mm and 5 m claim 63 , and wherein the feeding pressure of the gaseous reagent is between 0.1 and 0.5 bar.66. The method of claim 63 , wherein the diameter of the tube(s) is between 5 mm and 30 mm claim 63 , and the feeding pressure of the gaseous reagent is between 0.1 and 5 bar.67. The method of claim 63 , wherein the diameter of the tube(s) is between 5 and 30 mm claim 63 , and wherein the feeding pressure of the gaseous reagent is between 0.1 and 0.5 bar.68. The method of claim 63 , wherein the diameter of the tube(s) is between 10 mm and 25 mm claim 63 , and the feeding pressure of the gaseous reagent is between 0.1 and 5 bar.69. The method of claim 63 , wherein the diameter of the tube(s) is between 10 and 25 mm claim 63 , and wherein the feeding pressure of the gaseous reagent is between 0.1 and 0.5 bar.70. The method of claim 63 , wherein the gas flow rate is from 10 to 1500 L/min in each of said tube or tubes.71. The method of claim 64 , wherein the gas flow rate is from 10 to 1500 L/min in each of said tube or tubes.72. The method of claim 65 , ...

FILM OZONOLYSIS IN A TUBULAR OR MULTITUBULAR REACTOR

The disclosure relates to a method of performing ozonolysis or ozone-based oxidation on a liquid or emulsified reagent using a tubular falling firm reactor with one or multiple tubes wherein the combined ozone and carrier gas flow is co-current. 162.-. (canceled)63. A method of performing ozonolysis or ozone-based oxidation on a liquid or emulsified reagent using an industrial scale tubular falling film reactor with multiple tubes wherein the combined ozone and carrier gas flow is co-current , and wherein the ozonolysis occurs continuously without accumulation of large amounts of hazardous intermediates , and wherein the tubes are cooled by flow of a coolant.64. The method of claim 63 , wherein method comprises two or more industrial scale tubular falling film reactors with multiple tubes connected in series to process a continuous stream of the liquid or emulsified reagent.65. The method of claim 63 , wherein the carrier gas is selected from air claim 63 , oxygen (O) claim 63 , and an oxygen (O)/nitrogen (N) mixture.66. The method of claim 65 , wherein the carrier gas is an oxygen/nitrogen mixture comprising about 10% to about 30% oxygen and about 70% to about 90% nitrogen claim 65 , or 7.5-12.5% oxygen and 87.5-92.5% nitrogen.67. The method of claim 63 , wherein the liquid or emulsified reagent is an emulsion in water.68. The method of claim 63 , wherein the reactor comprises the multiple tubes in parallel enclosed in a cylindrical reactor.69. The method of claim 63 , wherein the diameter of the tube(s) is between 5 mm and 30 mm.70. The method of claim 69 , wherein the diameter of the tube(s) is between 10 mm and 25 mm.71. The method of claim 63 , wherein the gas flow rate is from 10 to 1500 L/min in each of said tube or tubes.72. The method of claim 63 , wherein the gas flow rate is about 150 L/min in each of said tube or tubes.73. The method of claim 63 , wherein the tubes are between 1 and 7 meters in length.74. The method of claim 73 , wherein the tubes are ...

Method for producing hexafluoroacetone or hydrate thereof

Hexafluoroacetone or a hydrate thereof is produced with a high yield by subjecting a 1-fluoro-4,4-bis(trifluoromethyl)-2,3,5-trioxolanyl ether compound represented by the general formula: wherein R is an alkyl group having 1 to 8 carbon atoms, an aryl group, or a benzyl group, which has been obtained by ozone oxidation of a heptafluoroisobutenyl ether compound, to a reduction reaction in the presence of a reducing agent selected from dialkyl sulfide containing an alkyl group having 3 or 4 carbon atoms, diaryl sulfide, diaryl disulfide, and diaralkyl sulfide.

PREPARATION METHOD OF CARBOXYLIC ACIDS OR KETONES USING OZONE, SINGLET STATE-OXYGEN ATOM OR HYDROXYL FREE RADICAL

A preparation method of carboxylic acids or ketones using ozone, singlet state oxygen atom O(D) or hydroxyl free radical is provided. The method includes: filling ozone, singlet state oxygen atom O(D) and/or hydroxyl free radical to cycloalkanes or benzenes at a pre-determined temperature and a pre-determined pressure in the presence or absence of light irradiation to produce carboxylic acids or ketones. The reaction occurs at room temperature and atmospheric pressure without producing harmful side products. The preparation method is a simple, low energy consuming, and eco-friendly method. 1. A method for preparation of ketones , comprising steps of: filling at least one of following three oxidants , comprising ozone , a singlet state-oxygen atom O(D) , and a hydroxyl free radical , to cycloalkanes at a pre-determined temperature and a pre-determined pressure without using transition metal catalysts or bromide catalysts and without using nitric acid or acetic acid as a solvent to produce cycloketones; wherein the pre-determined temperature is in a range between −10° C. and 50° C. , and the pre-determined pressure is in a range between 0.8 atm and 1.2 atm;wherein the cycloalkanes comprise cyclopentane, cyclohexane, cycloheptane, cyclooctane or a combination thereof; the cycloketones comprise cyclopentanone, cyclohexanone, cycloheptanone, cyclooctanone or a combination thereof.2. The method of claim 1 , wherein the singlet state-oxygen atom O(D) is produced by irradiation of ozone by a light beam having a wavelength between 230 nm and 330 nm.3. The method of claim 1 , wherein the hydroxyl free radical is produced by reaction of ozone with water claim 1 , by reaction of a singlet state-oxygen atom O(D) with water claim 1 , by reaction of hydrogen peroxide with ferrous ions claim 1 , or by reaction of hydrogen peroxide with cuprous ions.4. A method for preparation of carboxylic acids claim 1 , comprising steps of:{'sup': '1', 'claim-ref': {'@idref': 'CLM-00001', 'claim ...

Methods of carbon-carbon bond fragmentation

The present disclosure relates to methods of carbon-carbon bond fragmentation.

FREE RADICAL- AND REACTIVE OXYGEN SPECIES-REACTING COMPOUNDS

Provided are compounds that generate a peroxide when they react with ozone in the presence of water. Additionally, alkyne compounds reactive with a free radical, a reactive oxygen species (ROS) or another reactive species are provided. Also provided are enol ether, enamine, and vinal thioester compounds reactive with a free radical, a strong acid, a reactive oxygen species (ROS) or another reactive species. Additionally provided are compounds reactive with a free radical, an ROS or another reactive species. The compounds comprise a conjugated moiety operably joined to an alkene moiety and a resonance-transmitting moiety, wherein the resonance-transmitting moiety transmits an electron through the conjugated moiety to the alkene moiety, which reacts with the free radical, an ROS or another reactive species. Also provided are methods of decomposing a free radical, an ROS or another reactive species. The methods comprise contacting the free radical or ROS with any of the above compounds. Also provided are methods of using any of the compounds described herein, and compositions comprising those compounds. Additionally provided are methods of producing the above compounds. 2. The compound of claim 1 , wherein the peroxide is hydrogen peroxide claim 1 , an organic peroxide claim 1 , an organic hydroperoxide claim 1 , a peracid claim 1 , a peroxide ion claim 1 , superoxide claim 1 , benzoyl peroxide claim 1 , performic acid claim 1 , peracetic acid claim 1 , meta-chloroperoxybenzoid acid claim 1 , peroxybenzoic acid claim 1 , a peroxy acid claim 1 , or R—O—O—R.3. The compound of claim 1 , wherein the compound is a monomer.4. The compound of claim 3 , wherein the monomer is less than 1000 MW.5. The compound of claim 1 , wherein the compound is a polymer.69-. (canceled)11. (canceled)13. (canceled)14. The compound of claim 1 , wherein the compound is formulated as a skin treatment composition or as a coating.15. (canceled)16. A method of generating a peroxide claim 1 , the ...

METHOD FOR PRODUCING OXIDE

Provided is a method of oxidizing a substrate with excellent oxidizing power to yield a corresponding oxide. The method can employ a commercially available imide compound as intact as a catalyst and can produce the oxide in a high yield under mild conditions. 2. The method according to for producing an oxide claim 1 ,wherein a metallic compound is used as a promoter in combination with the imide compound as a catalyst.3. The method according to for producing an oxide claim 2 ,wherein the metallic compound includes at least one metal element selected from the group consisting of cobalt, manganese, zirconium, and molybdenum.4. The method according to for producing an oxide claim 1 ,wherein the oxidation as a reaction is performed using approximately no solvent.5. The method according to for producing an oxide claim 1 ,wherein the oxidation as a reaction is performed under normal atmospheric pressure.6. The method according to for producing an oxide claim 1 ,wherein the oxidation as a reaction is performed in the presence of at least one selected from the group consisting of nitric acid and nitrogen oxides.7. The method according to for producing an oxide claim 1 ,wherein the oxidation as a reaction is performed at a temperature of 100° C. or lower.10. The method according to for producing an oxide claim 2 ,wherein the oxidation as a reaction is performed using approximately no solvent.11. The method according to for producing an oxide claim 3 ,wherein the oxidation as a reaction is performed using approximately no solvent.12. The method according to for producing an oxide claim 2 ,wherein the oxidation as a reaction is performed under normal atmospheric pressure.13. The method according to for producing an oxide claim 3 ,wherein the oxidation as a reaction is performed under normal atmospheric pressure.14. The method according to for producing an oxide claim 4 ,wherein the oxidation as a reaction is performed under normal atmospheric pressure.15. The method according ...

Oxone-Aceton Mediated Metal Free Preparation of Syn-Diols

The present invention disclose a simple and high yielding process of Oxone-acetone mediated metal free syn-dihydroxylation of benzo fused olefins of formula (II) to obtain library of dioxolo compounds of formula (I). The invention further disclose a simple and high yielding process of Oxone-acetone mediated metal free syn-dihydroxylation of stilbene and its derivatives of formula (III) thereof. Also disclosed herein is Wacker-type oxidation of benzo-fused olefins of formula (X). The invention further disclose compounds of formula (I) which can be useful for the treatment of HIV, cancer or malaria. 2. The process as claimed in claim 1 , wherein the mixture of acetone claim 1 , ethyl acetate claim 1 , and water is in the ratio of 5:1:1.4. The process as claimed in claim 1 , wherein the compound of Formula I is selected from the group consisting of:(i) 2,2-dimethyl-8,8a-dihydro-3aH-indeno[1,2-d][1,3]dioxole (2a);(ii) 2,2-dimethyl-3a-propyl-8,8a-dihydro-3aH-indeno[1,2-d][1,3]dioxole (2b);(iii) 3a-(3-chloropropyl)-2,2-dimethyl-8,8a-dihydro-3aH-indeno[1,2-d][1,3]dioxole (2c);(iv) 8-(4-bromobutyl)-2,2-dimethyl-8,8a-dihydro-3aH-indeno[1,2-d][1,3]dioxole (2d);(v) 8-benzyl-2,2-dimethyl-8,8a-dihydro-3aH-indeno[1,2-d][1,3]dioxole (2e);(vi) 3a-benzyl-2,2-dimethyl-8,8a-dihydro-3aH-indeno[1,2-d][1,3]dioxole (2f);(vii) 3a-isopropyl-2,2-dimethyl-8,8a-dihydro-3aH-indeno[1,2-d][1,3]dioxole (2g);(viii) 3a-cyclohexyl-2,2-dimethyl-8,8a-dihydro-3aH-indeno[2,1-d][1,3]dioxole (2h);(ix) 2,2-dimethyl-3a-phenyl-8,8a-dihydro-3aH-indeno[1,2-d][1,3]dioxole (2i);(x) 7-(2,2-dimethyl-8,8a-dihydro-3aH-indeno[2,1-d][1,3]dioxol-3a-yl)heptan-2-one (2j);(xi) 2′,2′-dimethyl-3a′,8a′-dihydrospiro[cyclopentane-1,8′-indeno[2,1-d][1,3]dioxole](2k);(xii) 3a-(but-3-enyl)-2,2-dimethyl-8,8a-dihydro-3aH-indeno[2,1-d][1,3]dioxole (2m);(xiii) 2,2,9b-Trimethyl-3a,4,5,9b-tetrahydronaphtho[2,1-d][1,3]dioxole (2o);(xiv) 7-Methoxy-2,2,9b-trimethyl-3a,4,5,9b-tetrahydronaphtho[1,2-d][1,3]dioxole (2p);(xv) 2,2-Dimethyl-9b- ...

OZONOLYSIS OPERATIONS FOR GENERATION OF REDUCED AND/OR OXIDIZED PRODUCT STREAMS

The present invention relates to methods for safe and efficient use of hydrogen and oxygen in ozonolysis operations. The invention also relates to an ozonolysis process involving elements of both reductive and oxidative ozonolysis which are integrated in a continuous process. In one embodiment, the ozonolysis process of the present invention uses hydrogen and/or oxygen generated from water and electricity, which may be recycled to generate water and/or electricity. 1. An ozonolysis process for generation of linear alkyl aldehydes and diacids or acid-esters using elements of both the reductive and oxidative ozonolysis of a fatty acid or a fatty acid ester , wherein the reductive and the oxidative steps are integrated in a continuous process.2. A method comprising:a) providing oxygen and hydrogen, wherein said oxygen is utilized as a reagent for generating ozone; wherein said ozone is used in ozonolysis of a fatty acid or a fatty acid ester in an ozone reactor;b) inputting said fatty acid into said ozone reactor, in which said fatty acid or fatty acid ester absorbs said ozone, thereby forming a mixture comprising ozonated product stream comprising one or more compounds selected from ozonide, peroxide, aldehyde, ester, and acid; and i. partially reducing said ozonated product stream after said ozonated product stream enters a hydrogenation chamber to generate said partially reduced products comprising largely a linear aldehyde, wherein said linear aldehyde, when in the presence of water, form two layers comprising an organic phase while leaving the hydrogenation chamber;', 'j. fractionating said organic phase to separate said linear alkyl aldehyde from the remaining organic phase; and', 'k. oxidizing the remaining organic phase after fractionation at step (j) after the remaining organic phase enters into an oxidation chamber, resulting in the generation of said oxygenated products comprising said diacid or acid-ester;', 'thereby generating said linear alkyl aldehyde ...

OZONE-FACILITATED SELECTIVE OXIDATION OF ALKANES IN LIQUID CARBON DIOXIDE

A process for the ozonolysis of an alkane may comprise combining an alkane and ozone in a liquid phase medium comprising COunder conditions sufficient to oxidize the alkane to produce one or more non-combustion products. The liquid phase medium may be free of a super acid. 1. A process for the ozonolysis of an alkane , the process comprising combining an alkane and ozone in a liquid phase medium comprising COunder conditions sufficient to oxidize the alkane to produce one or more non-combustion products , wherein the liquid phase medium is free of a super acid.2. The process of claim 1 , wherein the alkane is a C1-C10 alkane.3. The process of claim 2 , wherein the alkane is selected from methane claim 2 , ethane claim 2 , propane claim 2 , iso-butane claim 2 , dimethyl propane claim 2 , heptane claim 2 , iso-octane claim 2 , cyclohexane claim 2 , and combinations thereof.4. The process of claim 2 , wherein the alkane is methane and the one or more non-combustion products comprise methanol.5. The process of claim 2 , wherein the alkane is n-heptane and the one or more non-combustion products comprise 4-heptanone claim 2 , 3-heptanone claim 2 , and 2-heptanone.6. The process of claim 2 , wherein the alkane is cyclohexane and the one or more non-combustion products comprise cyclohexanone and cyclohexanol.7. The process of claim 1 , wherein the liquid phase medium is liquid CO.8. The process of claim 1 , wherein the process is carried out in the presence of a catalyst capable of generating an active species derived from the ozone and the conditions are sufficient to generate the active species.9. The process of claim 8 , wherein the catalyst is a supported transition metal catalyst comprising transition metals incorporated into a metal oxide substrate claim 8 , wherein the metal oxide substrate is an oxide of a metal selected from aluminum claim 8 , silicon claim 8 , titanium claim 8 , and magnesium.10. The process of claim 9 , wherein the supported transition metal ...

Methods and Systems for Generating Aldehydes from Organic Seed Oils

Methods for generating aldehyde-containing compounds in organic seed oils utilizing direct current and, optionally, ozone without the use of added electrolytes and reducing compounds are disclosed, as are compositions generated by such methods. The reactions can be performed efficiently at ambient temperatures and pressures. These compositions have particular utility as additives to fuels and lubricating oils derived from petrochemical sources. 1. A method for producing a petroleum product additive , comprising:providing a vegetable oil;providing a first electrode and a second electrode;submerging at least a portion of the first electrode and at least a portion of the second electrode into the vegetable oil;applying, in the absence of an added chemical reductants and in the absence of an added metal salt, an electrical potential to the first electrode and the second electrode for at least 8 hours, such that the electrical potential generated between the first electrode and the second electrode is of fixed polarity, wherein the potential is at least 3 kV; andgenerating the petroleum product additive.2. The method of claim 1 , wherein the first electrode comprises a conductive material selected from the group consisting of copper claim 1 , brass claim 1 , stainless steel claim 1 , conductive polymer claim 1 , and graphite.3. The method of claim 1 , wherein the second electrode comprises a conductive material selected from the group consisting of copper claim 1 , brass claim 1 , stainless steel claim 1 , conductive polymer claim 1 , and graphite.4. The method of claim 1 , wherein the first electrode and the second electrode have the same composition.5. The method of claim 1 , wherein a gap is introduced between the first electrode and the second electrode claim 1 , wherein the gap is from 5 mm to 100 mm.6. The method of claim 5 , wherein the gap is about 40 mm.7. The method of claim 5 , wherein the vegetable oil is exposed to the first electrode and the second ...

FILM OZONOLYSIS IN A TUBULAR OR MULTITUBULAR REACTOR

The disclosure relates to a method of performing ozonolysis or ozone-based oxidation on a liquid or emulsified reagent using a tubular falling film reactor with one or multiple tubes wherein the combined ozone and carrier gas flow is co-current. 1. A method of performing ozonolysis or ozone-based oxidation on a liquid or emulsified reagent using a tubular falling film reactor with one or multiple tubes wherein the combined ozone and carrier gas flow is co-current.2. The method of claim 1 , wherein the diameter of the tube(s) is between 5 mm and 5 m.3. The method of claim 2 , wherein the diameter of the tube(s) is between 5 and 30 mm.4. The method of claim 2 , wherein the diameter of the tube(s) is between 5 and 50 mm.5. The method of claim 2 , wherein the diameter of the tube(s) is between 50 mm and 5 m.6. The method of where the tube diameter is between 50 mm and 5 m and an annular element is added in to regulate gas flow and to add additional film surface area.7. The method of any one of - claim 1 , wherein the length of the tube(s) is between 1 and 20 m.8. The method of claim 7 , wherein the length of the tube(s) is between 1 and 7 m.9. The method of claim 8 , wherein the length of the tube(s) is 1.7 m.10. The method of claim 8 , wherein the length of the tube(s) is 6 m.11. The method of claim 7 , wherein the length of the tube(s) is between 7 and 20 m.12. The method of any one of - claim 7 , wherein the distribution of gas within the tube(s) may be controlled by annular spaces for gas flow within the tube(s).13. The method of any one of - claim 7 , wherein multiple falling film tube reactors are used in series to process a continuous stream of liquid or emulsified reagent.14. A method of performing ozonolysis or ozone-based oxidation on a liquid or emulsified reagent with a gaseous reagent comprising ozone and one or more carrier gases claim 7 , the method comprising:(a) feeding the liquid or emulsified reagent from a common liquid or emulsified reagent feeding ...

OXIDATION REACTOR AND PRODUCTION METHOD FOR OXIDE

Provided is an oxidation reactor capable of oxidizing hydrocarbons with both good reaction efficiency and good energy efficiency. This oxidation reactor includes a liquid inlet channel, a gas inlet channel, a gas-liquid mixing unit, and a flow reactor. Through the liquid inlet channel, a liquid containing a reaction substrate hydrocarbon is introduced. Through the gas inlet channel, a gas containing oxygen and ozone is introduced. The gas-liquid mixing unit mixes the liquid introduced from the liquid inlet channel with the gas introduced from the gas inlet channel. In the flow reactor, an oxidation catalyst is immobilized or packed. In the oxidation reactor, the flow reactor includes a monolith support and the oxidation catalyst immobilized to or packed in the monolith support. In addition or alternatively, the gas-liquid mixing unit includes a microbubble generator. 1. An oxidation reactor comprising:a liquid inlet channel through which a liquid containing a reaction substrate hydrocarbon is introduced;a gas inlet channel through which a gas containing oxygen and ozone is introduced;a gas-liquid mixing unit that mixes the liquid introduced from the liquid inlet channel with the gas introduced from the gas inlet channel; and a monolith support; and', 'the oxidation catalyst immobilized to or packed in the monolith support, and/or, 'a flow reactor in which an oxidation catalyst is immobilized or packed, the flow reactor comprisingthe gas-liquid mixing unit comprising a microbubble generator.2. The oxidation reactor according to claim 1 , further comprising a gas-liquid separator downstream from the flow reactor.3. The oxidation reactor according to claim 2 , further comprising a circulation channel through which at least part of a liquid separated in the gas-liquid separator is recycled to the gas-liquid mixing unit or to a portion upstream from the gas-liquid mixing unit.4. The oxidation reactor according to claim 2 , further comprisinga circulation channel through ...

SOLID ACID CATALYST AND METHOD FOR PRODUCING OXIDE

Provided is a solid acid catalyst for use in oxidation of a substrate in the coexistence of oxygen and ozone (solid acid catalyst for oxygen-ozone-coexisting oxidation). The solid acid catalyst enables oxidation of the substrate with a high conversion. This solid acid catalyst for oxygen-ozone-coexisting oxidation is a solid acid catalyst for use in an oxidation reaction to oxidize a substrate (A) in the coexistence of oxygen and ozone. The solid acid catalyst includes a transition metal in the form of an elementary substance, a compound, or an ion, and a support supporting the transition metal. The support includes, at least in its surface, a strong acid or super strong acid having a Hammett acidity function (H) of −9 or less. The support is preferably a pellet or particle made of a fluorinated sulfonic acid resin, or a support including a solid and a layer of a fluorinated sulfonic acid resin disposed on the solid. 1. A solid acid catalyst for use in an oxidation reaction to oxidize a substrate (A) in coexistence of oxygen and ozone , the solid acid catalyst comprising:a transition metal in a form of an elementary substance, a compound, or an ion; and {'sub': '0', 'a strong acid or super strong acid having a Hammett acidity function (H) of −9 or less,'}, 'a support supporting the transition metal, the support comprising, at least on a surface thereof,'} (A1) compounds containing a heteroatom and a carbon-hydrogen bond at a position adjacent to the heteroatom;', '(A2) compounds containing a carbon-heteroatom double bond;', '(A3) compounds containing a methine carbon atom;', '(A4) compounds containing an unsaturated bond and a carbon-hydrogen bond at a position adjacent to the unsaturated bond;', '(A5) alicyclic compounds;', '(A6) conjugated compounds;', '(A7) amine compounds;', '(A8) aromatic compounds;', '(A9) straight chain alkanes; and', '(A10) olefins., 'the substrate (A) comprising a compound selected from the group consisting of2. A solid acid catalyst for ...

Continuous process for the ozonolysis of lignin to yield aromatic monomers

A method for processing lignin may comprise flowing a lignin composition comprising a lignin polymer and a solvent through a reaction chamber of a continuous flow reactor, the lignin polymer comprising hydroxycinnamic groups bound to a polymeric backbone; flowing ozone through the reaction chamber containing the lignin composition under conditions to maximize oxidative cleavage of the hydroxycinnamic groups to produce one or more types of aromatic monomers while minimizing oxidative cleavage of the polymeric backbone; and collecting the one or more types of aromatic monomers, e.g., by a size-selective membrane separation device.

PROCESS FOR THE PREPARATION OF METHOXYMELONAL

A process of forming methoxymelonal comprising the steps of treating a solution of citronellene to ozonolysis, and hydrogenating the product formed to provide methoxymelonal. 2. The process according to wherein the ozonolysis is carried out in a solvent selected from methanol or water.3. The process according to wherein the reductive work-up step is a hydrogenation carried out using palladium as a catalyst.4. The process according to wherein the reduction step is carried out using sulfites as reducing agents.5. Methoxymelonal obtained by the process according to .6. A perfume composition comprising methoxymelonal according to .7. A method of forming a perfume composition having the impression of p-tert-butyl-alpha-methyldihydrocinnamic aldehyde claim 5 , comprising the step of adding to said composition methoxymelonal as defined in .8. A perfume composition having the impression of p-tert-butyl-alpha-methyldihydrocinnamic aldehyde claim 5 , comprising methoxymelonal as defined in .9. A perfume composition comprising methoxymelonal as defined in .10. The perfume composition according to additionally comprising 3-(4-tert-Butylphenyl)propionaldehyde (Bourgeonal) claim 8 , 2-Methyl-4-phenylbutan-2-ol (Dimethylphenylethylcarbinol) claim 8 , cis-4-(Isopropyl)cyclohexanemethanol (Mayol) claim 8 , 1-(1-hydroxyethyl)-4-(1-methylethypcyclohexane (Mugetanol) claim 8 , (4-Methyl-3-pentenyl)cyclohexenecarbaldehyde (Citrusal) claim 8 , 3-(p-(2-Methylpropyl)phenyl)-2-methylpropionaldehyde (Silvial) claim 8 , 3-p-Cumenyl-2-methylpropionaldehyde (Cyclamenaldehyde) claim 8 , mixture of: cis-tetrahydro-2-isobutyl-4-methylpyran-4-ol; trans-tetrahydro-2-isobutyl-4-methylpyran-4-ol (Florol) claim 8 , 5 claim 8 ,9-Dimethyl-4 claim 8 ,8-decadienal (Geraldehyde) claim 8 , beta.-methyl-3-(1-methylethyl)benzenepropanal (Florhydral) claim 8 , Octahydro-8 claim 8 ,8-dimethylnaphthalene-2-carbaldehyde (Cyclomyral) claim 8 , alpha.-Methyl-1 claim 8 ,3-benzodioxole-5-propionaldehyde (Helional) ...

TERPENE-DERIVED ACIDS AND ESTERS AND METHODS FOR PREPARING AND USING SAME

The invention relates to terpene-derived acids and esters thereof as well as to processes for synthesizing them. 2. The method of claim 1 , wherein the mixture comprising the compound of formula (I) wherein Ris H and the compound of formula (IC) is an aqueous mixture.3. The method of claim 2 , wherein separating the compound of formula (I) from the compound of formula (IC) is performed by:adjusting the pH of the aqueous mixture to a first pH value that is between 6 and 10 to obtain a first organic phase that comprises the compound of formula (IC) and a first aqueous phase that comprises a salt of compound of formula (I);separating the first aqueous phase from the first organic phase;optionally adding an oxidant to the separated first aqueous phase;{'sub': '1', 'adjusting the pH of the first aqueous solution to a second pH value that is not greater than 5 to obtain a second organic phase that comprises the compound of formula (I) wherein Ris H and a second aqueous phase; and'}{'sub': '1', 'separating the second organic phase from the second aqueous phase to obtain the compound of formula (I) wherein Ris H.'}4. The method of claim 3 , wherein the second pH value is not greater than 4.5. The method of claim 1 , further comprising reacting the compound of formula I wherein Ris H claim 1 , with an alcohol ROH wherein Ris unsubstituted or substituted C-Calkyl or unsubstituted or substituted C-Calkenyl claim 1 , to produce a compound of formula I wherein Ris unsubstituted or substituted C-Calkyl claim 1 , or unsubstituted or substituted C-Calkenyl.6. The method of claim 1 , wherein the oxidant is a peroxide.7. The method of claim 6 , wherein the peroxide is hydrogen peroxide.8. The method of claim 1 , wherein the reaction of the compound having the formula (IB) with ozone is carried out in the presence of a solvent.9. The method of claim 8 , wherein the solvent comprises water claim 8 , an organic solvent or a mixture there of.10. The method of claim 8 , wherein the ...

OZONOLYSIS FOR ACTIVATION OF COMPOUNDS AND DEGRADATION OF OZONE

Provided is an inactive compound that is activated by reaction with ozone into an active compound having a carbonyl oxygen. Also provided is a method of activating the above inactive compounds. Further provided is a method of treating a disease or condition in a subject using the above compound at a site that is not exposed to atmospheric ozone. Additionally provided is a method of determining internal ozonolysis in a subject using the above compound. Also provided is a molecule less than 1000 mw, having a double bond that is reactive with ozone, and forms a nontoxic compound after reacting with ozone. Further provided is a method of degrading ozone. 25-. (canceled)6. The compound of claim 1 , wherein X is a planar compound comprising at least three aromatic rings.78-. (canceled)1016-. (canceled)17. The compound of claim 1 , wherein Ris NRor CR claim 1 , where Ris H claim 1 , a substituted or unsubstituted alkyl claim 1 , substituted or unsubstituted heteroalkyl claim 1 , substituted or unsubstituted cycloalkyl claim 1 , substituted or unsubstituted heterocycloalkyl claim 1 , substituted or unsubstituted aryl claim 1 , substituted or unsubstituted heteroaryl claim 1 , substituted or unsubstituted arylalkyl claim 1 , or substituted or unsubstituted heteroarylalkyl.20. The compound of claim 1 , wherein Rcomprises an oligomeric or polymeric repeat comprising more than one X.2230-. (canceled)31. The compound of claim 1 , wherein the active compound is a pharmaceutical.32. The compound of claim 31 , wherein the pharmaceutical is useful for treatment of a-cancer.3334-. (canceled)35. A method of treating a patient with cancer claim 32 , the method comprising administering the compound of to the patient in an amount sufficient to treat the patient.36. The method of claim 35 , further comprising administering ozone to the patient.3738-. (canceled)39. A method of activating the inactive compound of claim 1 , the method comprising exposing the inactive compound with ozone for ...

REACTION SEQUENCE FOR THE SYNTHESIS OF NOOTKATONE, DIHYDRONOOTKATONE, AND TETRAHYDRONOOTKATONE

An inexpensive, stereoselective synthesis for nootkatone, tetrahydronootkatone, and their derivatives is disclosed utilizing ozonolysis. The starting materials used in the synthesis are inexpensive and the reactions are commercially feasible and amenable to scaling up. The principal starting material, (−)-β-Pinene, is on the GRAS list (generally recognized as safe). 2. The process of claim 1 , wherein the ozonolysis step comprises{'sub': '2', 'oxidizing β-pinene with ozone/Oin MeOH; and'}{'sub': 3', '2, 'adding (CH)S to produce nopinone.'}3. The process of claim 1 , wherein the ozonolysis step comprises{'sub': 2', '2', '2, 'oxidizing β-pinene with ozone/Oin CHCl; and'}adding AcOH and zinc to produce nopinone.5. The process of claim 4 , wherein the ozonolysis of Compound 6 comprises{'sub': 2', '3', '2, 'oxidizing Compound 6 with ozone/Oin MeOH; and adding (CH)S to produce Compound 7.'}6. The process of claim 4 , wherein the ozonolysis of Compound 6 comprises{'sub': 2', '2', '2, 'oxidizing Compound 6 with ozone/Oin CHCl; and'}adding AcOH and zinc to produce Compound 7.8. The process of claim 7 , wherein the ozonolysis of Compound 6 comprises{'sub': 2', '2', '2, 'oxidizing Compound 6 with ozone/Oin CHCl; and'}adding AcOH and zinc to produce Compound 7.9. The process of claim 7 , wherein the ozonolysis of Compound 6 comprises{'sub': '2', 'oxidizing Compound 6 with ozone/Oin MeOH; and'}{'sub': 3', '2, 'adding (CH)S to produce Compound 7.'}11. The method of claim 10 , wherein the ozonolysis step comprises:{'sub': '2', 'oxidizing Compound 1 with ozone/Oin MeOH; and'}{'sub': 3', '2, 'adding (CH)S to produce Compound 2.'}12. The process of claim 10 , wherein the ozonolysis step comprises:{'sub': 2', '2', '2, 'oxidizing β-pinene with ozone/Oin CHCl; and'}adding AcOH and zinc to produce nopinone.14. The process of claim 13 , wherein the ozonolysis step comprises{'sub': '2', 'oxidizing β-pinene with ozone/Oin MeOH; and'}{'sub': 3', '2, 'adding (CH)S to produce nopinone.'}15. ...

Method for the production of an ozonized olive oil

The present invention relates to a method for the production of an ozonized olive oil with a controlled degree of ozonization, wherein said method comprises at least one step of putting the olive oil into contact with ozone in the presence of water.

Hydrogenolytisk reduksjon av peroksydiske ozonolyseprodukter

Det er beskrevet en fremgangsmåte for hydrogenolytlsk reduksjon av peroksydiske ozonolyseprodukter til de tilsvarende karbonylforbindelsene l nærvær av Inert, organisk fortynnlngsmlddel og l nærvær av en monolltt- katalysator ved hydrogentrykk på 0,01 til 2,0 mPa og ved temperaturer på -10 til 150'C, og en Innretning for katalytisk hydrogenolyse av kjemiske forbindelser som ved hydrogenolyse gir enhetlige, nye produkter med hydrogen.

Metering method for particulate material

There is provided a method for metering a quantity of a particulate material onto the surface of a porous retainer comprising the steps of: exposing a first surface of a porous retainer to a pool of particulate material; applying a vacuum to a second surface of the porous retainer to meter material on the first surface; and adjusting the level of the vacuum to regulate the quantity of material metered on the retainer.

Intermediates and process for the preparation of sandalwood oil building blocks

Green synthesis method of natural benzaldehyde

本发明公开了一种天然苯甲醛的绿色合成方法，包括以下步骤：在天然肉桂醛中加入V 2 O 5 /TiO 2 催化剂，再加入乙酸乙酯，冷却下通入臭氧开始反应，用气相色谱跟踪反应进程，当反应结束后，加入亚硫酸氢钠除去过氧值，减压蒸馏分离得到天然苯甲醛。所述V 2 O 5 /TiO 2 催化剂通过以下方法制得：配制偏钒酸铵和草酸的混合溶液，在溶液中再加入TiO 2 载体浸渍，将浸渍后的载体干燥、焙烧后得到V 2 O 5 /TiO 2 催化剂。本发明以V 2 O 5 /TiO 2 为催化剂，采用臭氧对天然肉桂醛进行氧化，制备天然苯甲醛，反应过程中没有引入其它的反应物，保持天然原料的天然特性，本方法工艺简单、绿色无污染。

Metering method for particulate material

There is provided a method for metering a quantity of a particulate material onto the surface of a porous retainer comprising the steps of: exposing a first surface of a porous retainer to a pool of particulate material; applying a vacuum to a second surface of the porous retainer to meter material on the first surface; and adjusting the level of the vacuum to regulate the quantity of material metered on the retainer.

Metering method for particulate material

There is provided a method for metering a quantity of a particulate material onto the surface of a porous retainer comprising the steps of: exposing a first surface of a porous retainer to a pool of particulate material; applying a vacuum to a second surface of the porous retainer to meter material on the first surface; and adjusting the level of the vacuum to regulate the quantity of material metered on the retainer.

Method and reaction device for preparing benzaldehyde by supergravity ozone oxidation of styrene

本发明属于精细有机合成技术领域，针对苯乙烯合成苯甲醛化合物方法中存在的反应条件苛刻，负载型催化剂的工艺流程繁冗，副产物多且苯甲醛产率低等缺点，提供了一种超重力臭氧氧化苯乙烯制备苯甲醛的方法及反应装置，以臭氧作为氧化剂，具有绿色、高效以及无二次污染等优点；以旋转填料床作为反应器，高速旋转的填料对流体进行极大地剪切和破碎，产生巨大和快速更新的相界面，使得气液传质过程得到了极大的强化，进而提高臭氧利用率，同时也加快了反应进程。本发明具有操作简单、绿色环保、原子经济性高、反应条件温和以及易于工业化等优点。

Catechol diethers as selective PDEIV inhibitors

This invention relates to 4-substituted catechol diether compounds which are selective inhibitors of phosphodiesterase (PDE) type IV. The compounds of the present invention are useful in inhibiting PDE IV and in the treatment of AIDS, asthma, bronchitis, chronic obstructive airways disease, psoriasis, allergic rhinitis, dermatitis and other inflammatory diseases. This invention also relates to pharmaceutical compositions comprising the compounds hereof. ##STR1##

Oxidative cleavage of unsaturated oils and products obtained therefrom

(57)【要約】 本発明は、硬化された熱硬化性樹脂が、カシューナッツの殻液のオゾン分解開裂生成物以外の、不飽和の植物油または動物油中の不飽和結合の酸化開裂によって生成されるアルデヒドおよびパーオキサイドならびにこれらの混合物から選択される酸化開裂生成物から得られる、粒状または繊維状材料及び硬化された熱硬化性樹脂からつくられる母材を含む固体複合材料を提供する。また、本発明は、ハイドロパーオキサイドが生成するように植物油をオゾンで処理し（例えば、油のための溶媒としてアルコールの存在で）、そしてハイドロパーオキサイドを還元糖で還元開裂することからなるアルデヒドおよび／またはパーオキサイドの製造方法を提供する。

Method of metering particulate matter

Oxygenated alicyclic derivatives useful as odoriferous and flavouring ingredients

1435887 Acrylic alkenymers; alkenyne substituted cycloalkenes FIRMENICH SA 29 Jan 1975 [29 Jan 1974] 3914/75 Heading C5E [Also in Divisions C2 and A5] α-Dehydrolinalool is heated with B(OH) 3 to yield a mixture comprising 3-methylene-7- methyl - oct - 1 - yn - 7 - ene and 3,7 - dimethyl - oct - 1 - yn - 3,7 - diene. This mixture may also be obtained using #-dehydrolinalool. This mixture may be reacted with allyl chloride to give a mixture of 6-methylene-10-methylundeca - 1,10 - diene - 4 - yne and 6 - methylene - 10 - methyl - undeca - 1,9 - dien - 4 - yne which may be cyclized with formic acid to a mixture of 1-(3,3-dimethyl-cyclohex-1 and 6- en-1-yl)-pent-4-en-1-yne. This mixture may also be obtained by treating 1-(1-hydroxy-3,3- dimethyl - cyclohexyl) - pent - 4 - en - 1 - yne with B(OH) 3 . (3,3-Dimethyl-cyclohex-5-en-1- yliden)-pent-4-ene is obtained by reacting 3,3- dimethyl-cyclohex-5-en-1-one with the phosphonium bromide salt obtained from triphenylphosphine and 5-bromopent-1-ene.

PROCESS FOR THE TREATMENT OF LIGNINS FOR THE PRODUCTION OF ALDEHYDES AND / OR PHENOLIC ACIDS

L'invention concerne un procédé de traitement de lignines par ozonation en vue de l'obtention sélective d'aldéhydes et/ou d'acides phénoliques. Ce procédé consiste à mettre les lignines en contact avec l'ozone dans un bain de solvant liquide à base de trichloro-1,1,2 trifluoro-1,2,2 éthane; on constate la formation d'aldéhydes et/ou acides phénoliques sans dégradation notable en petites molécules, ces composés étant isolés du solvant et des lignines solides résiduelles en particulier par filtration et distillation. Le rendement est amélioré lorsque l'on utilise un bain de solvant liquide dans lequel de l'alcool est mélangé en proportion minoritaire au trichloro-1,1,2 trifluoro-1,2,2 éthane. Le procédé de l'invention peut en particulier être appliqué sur des lignines extraites de matières végétales à fibres papetières, telles que bois, bagasses, pailles... afin de valoriser celles-ci en fournissant un produit à forte valeur ajoutée. The invention relates to a process for treating lignins by ozonation with a view to the selective production of aldehydes and / or phenolic acids. This process consists in bringing the lignins into contact with ozone in a bath of liquid solvent based on 1,1,2-trichloro-1,2,2-trifluoroethane; the formation of aldehydes and / or phenolic acids is observed without appreciable degradation into small molecules, these compounds being isolated from the solvent and from the residual solid lignins, in particular by filtration and distillation. The yield is improved when using a bath of liquid solvent in which alcohol is mixed in a minor proportion with 1,1,2-trichloro-1,2,2-trifluoroethane. The process of the invention can in particular be applied to lignins extracted from plant materials with papermaking fibers, such as wood, bagasses, straws, etc. in order to enhance the latter by providing a product with high added value.

Patent FR2259091A1

Patent GB1237923A

1,237,923. Terpene derivatives. L. GIVAUDAN & CIE S.A. 4 July, 1968 [7 July, 1967; 1 Nov., 1967], No. 1005/71. Divided out of 1,237,922. Heading C2C. Novel compounds of formula where R is CH 2 OH, CHO or COOH and a double bond is present in one of the positions indicated by broken lines are prepared by ozonizing a compound of formula i.e. cis- or trans-ociniene or myrcene, and decomposing the product with a powerful reducing agent, a mild reducing agent or an oxidizing agent respectively.

Method and device for the chemical transformation of a flowing gas

Improvement in the manufacture of aldehydes

Process for producing ortho-isopropyl phenol derivatives

Cette invention porte sur un procédé de production de dérivés de phénol ortho-isopropylés répondant à la formule générale (VIII) suivante (CF DESSIN DANS BOPI) (dans la formule ci-dessus, R1 est l'atome d'hydrogène ou un groupe alcoyle inférieur en C1-C4). Le procédé de production de dérivés de phénol ortho-isopropylés (VIII) de la présente invention est caractérisé en ce que l'isomère de position recherché est obtenu au moyen d'un réarrangement de Claisen du phényl allyl éther, en l'absence de catalyseur, à l'air libre, et en ce qu'un seul isomère est obtenu par oxydation et réduction de l'isomère de position ainsi obtenu. Selon la présente invention, les dérivés de phénol ortho-isopropylés (VIII) d'une pureté élevée peuvent être préparés à basse température et à basse pression, sans donner de sous-produits ni exiger une procédure de séparation complexe. This invention relates to a process for producing ortho-isopropylated phenol derivatives of the following general formula (VIII) (DRAWING CF IN BOPI) (in the above formula, R1 is the hydrogen atom or an alkyl group lower than C1-C4). The process for producing ortho-isopropylated phenol derivatives (VIII) of the present invention is characterized in that the desired positional isomer is obtained by means of a Claisen rearrangement of the phenyl allyl ether, in the absence of a catalyst. , in the open air, and in that a single isomer is obtained by oxidation and reduction of the positional isomer thus obtained. According to the present invention, ortho-isopropylated phenol derivatives (VIII) of high purity can be prepared at low temperature and at low pressure, without giving any by-products or requiring a complex separation procedure.

Preparation of a cyclopropylacetic acid and its derivatives

ABSTRACT Novel 2-formyl-3,3-dimethylcyclopropylacetic acid, its esters, salts or dialkylacetals are prepared by a process which comprises ozonolysis of 3-acetyl-6,6-dimethylbicyclo [3.1.0]-2-hexene, reductive cleavage of the ozonide product thus found, and optionally converting the free acid into an ester, a salt or a dialkyl acetal. The acetic acid derivative is an inter-mediate in the manufacture of pyrethroid insecticides. The bicyclohexene starting material is preferably obtained from the naturally-occurring terpene (+)-3-carene.

PREPARATION OF CYCLOPROPYLACETIC ACID AND ITS DERIVATIVES

Novel 2-formyl-3,3-dimethylcyclopropylacetic acid (formula I), its esters, salts or dialkyl acetals are prepared by a process which comprises the ozonisation of 3-acetyl-6,6-dimethylbicyclo [3.1.0]hex-2-ene of the formula II, reductive cleavage of the ozonide formed and if desired conversion of the free acid into an ester, a salt or a dialkyl acetal. The acetic acid derivative is an intermediate for the preparation of pyrethroid insecticides. The bicyclohexene starting substance is preferably obtained from the naturally occurring terpene (+)-3-carene.

Patent FR2357522B1

Vanillin manufacturing process

Dideoxy-l-arabinitol derivatives as antiviral compounds

Novel antiviral compounds are disclosed having the following formula wherein R1 is C1-C14 alkyl or C1-C14 hydroxyalkyl or C3-C12 alkanoyl or a substituted or unsubstituted aryl radical having six to ten carbon atoms; and wherein R2, R3 and R4 are the same or different and each is H or acyl having one to six carbon atoms; provided, however, that when R2, R3 and R4 are each H, then R1 is C4-C9 alkyl or C2-C5 hydroxyalkyl or C3-C12 alkanoyl.

4,4,5,8-Tetramethyl-1-oxaspiro(2.5) octane, process for its preparation and its use as a starting material in the preparation of 2,2,3,6-tetramethyl cyclohexane carboxaldehyde

Method for preparing hexanedial

本申请公开了一种制备己二醛的方法，所述制备方法包括：将含有环己烯的混合液与含臭氧的混合气在反应条件下进行氧化反应，得到己二醛；其中，所述反应条件包括以负载型金属氧化物作为催化剂，所述金属氧化物由W氧化物和Mo氧化物组成。本发明采用负载型W、Mo双金属氧化物为催化剂，高选择性氧化环己烯生产己二醛，克服了环己烯氧化反应中需使用贵金属配合物和高碘酸钠的缺点，本发明采用臭氧为氧化剂，将环己烯选择性氧化为己二醛，产物选择性高。

Improvements to processes for the production of dicarbonyl compounds

Patent FR1572831A

Process for preparing orthoisopropylated phenol derivatives.

"4,4,5,8-Tetramethyl-1-oxaspiro [2.5] octane, a method for preparing the same, and 2,2,3,6-tetramethyl-cyclohexane-carbaldehyde, a method for preparing the same"

Polyenic Alcohols, Aldehydes and Acids

1,182,212. Polyenic aldehydes, alcohols and acids. L. GIVAUDAN & CIE S.A. 4 Sept., 1968 [15 Sept., 1967], No. 41975/68. Heading C2C. Compounds of Formula I where R is CH 2 OH, CHO or COOH and the broken lines represent a double bond emanating from C-atom 3 are prepared by ozonizing and reducing the ozonization product to the alcohol or ketone or oxidizing it to the acid, using known methods. The aldehydes of Formula I are converted to sinensals by reaction with or by reaction with (R 1 =C 1-6 alkyl) to give a tetraene ester of formula reducing this to the corresponding alcohol and oxidizing the latter to sinensal is prepared by reacting EtI with (Ph) 3 P and reacting the resulting ethyltriphenylphosphonium iodide with butyllithium and methyl formate.

Novel aldol derivatives and production thereof

A process for producing novel aldol derivatives of the formula, ##STR1## wherein C=W is a carbonyl group or a protected carbonyl group which comprises reacting a compound of the formula: ##STR2## wherein C=W is as defined above in the presence of an acid or a base at a temperature ranging from -70° C. to room temperature. The novel aldol derivatives of the above formula are useful as intermediate for producing methanoprostacyclin derivatives which are useful medicines for prevention of thrombosis.

Process for the preparation of alpha-omega-alkanedicarboxylic acids.

Process for the catalytic gas phase oxidation of toluene with a gas containing molecular oxygen

ABSTRACT OF THE DISCLOSURE A catalyst mass of silver vanadate and iron vanadate, optionally also including at least one rare earth metal vanadate, is used in the vapor phase oxidative conversion of toluene to benzaldehyde and/or benzoic acid using oxygen or ozone and steam according to the disclosed process. Catalyst activity and selectivity are improved.

Catechol diethers as selective pde iv inhibitors

This invention relates to 4-substituted catechol diether compounds which are selective inhibitors of phosphodiesterase (PDE) type IV. The compounds of the present invention are useful in inhibiting PDE IV and in the treatment of AIDS, asthma, arthritis, bronchitis, chronic obstructive airways disease, psoriasis, allergic rhinitis, dermatitis and other inflammatory diseases. This invention also relates to pharmaceutical compositions comprising the compounds hereof.

Patent DE97620C

Methods of making reversible crosslinked polymers and related methods

Methods are provided for making reversible crosslinked polymers. Exemplary methods comprise reacting first and second thermoplastic polymers having non-hindered olefins in the presence of a metathesis catalyst under conditions sufficient to form a crosslinked polymer. In certain embodiments, the methods comprise providing a crosslink promoting additive to improve the strength of the crosslinked polymer. In some embodiments, the methods comprise decrosslinking a crosslinked polymer through a metathesis or an ozonolysis reaction.

Supported ruthenium nanoparticle catalyst for CIS- dihydroxylation and oxidative cleavage of alkenes

Oxidative cleavage of unsaturated oils and products obtained therefrom

The invention provides a solid composite material comprising a matrix formed from a particulate or fibrous material and a cured thermosetting resin, wherein the cured thermosetting resin is derived from an oxidative cleavage product selected from aldehydes and peroxides and mixtures thereof formed by the oxidative cleavage of an unsaturated bond in an unsaturated plant or animal oil, other than the ozonolysis cleavage product of cashew nut shell liquid. Also provided is a process for the production of aldehydes and/or peroxides, which process comprises the treatment of a vegetable oil with ozone (e.g in the presence of an alcohol as a solvent for the oil) so that hydroperoxides are produced, and the reductive cleavage of the hydroperoxides with a reducing sugar.

Ozonolysis operations for generation of reduced and/or oxidized product streams

The present invention relates to methods for safe and efficient use of hydrogen and oxygen in ozonolysis operations. The invention also relates to an ozonolysis process involving elements of both reductive and oxidative ozonolysis which are integrated in a continuous process. In one embodiment, the ozonolysis process of the present invention uses hydrogen and/or oxygen generated from water and electricity, which may be recycled to generate water and/or electricity.

Method for preparing vanillin through sodium isoeugenol process

一种异丁香酚钠法制备香兰素的方法，涉及化工技术领域，将异丁香酚钠和水混合加入氧化反应釜中进行氧化反应并且接通气管输入臭氧，增加臭氧的速率带动氧化反应釜内的液体搅拌翻动进行液相氧化反应，结束后的液体投入进行分层，然后加入亚硫酸钠溶液分解臭氧化物，将臭氧化物进行中和，再水洗便得到香兰素粗品，投入精致釜中进行精细结晶处理，然后干燥后得到成品，包装入库。本发明的有益效果是：本发明制备方便简单，环保无污染，设备投资少，纯度高，便于操作，制备的香兰素使用效果好，安全可靠。

4-Methylene-5-hexen-1-ol

A process for preparing compounds of the type of sinensal, which is suitable as a flavor-imparting agent of orange aroma, and novel intermediates including those having the general formula: ##SPC1## Wherein R signifies a CH 2 OH, CHO or COOH group and the broken lines represent a double bond emanating from C-atom 4, are disclosed.

PROCESS FOR THE PREPARATION OF PERFUMED OR AROMATIZED PRODUCTS, AND PERFUMED OR AROMATIZED ARTICLES (1-CYCLE-ALKYL) -PROCESSED PREPARATION PRODUCTS (1).

Process for the production of glyoxal, alkylglyoxales and of their acetales

Process for preparing hexanedial from cyclohexene

本申请公开了一种环己烯制备己二醛的工艺，所述制备方法包括：将混合液与含臭氧的混合气分别注入微通道反应器内，在反应条件下进行氧化反应，得到己二醛，其中，所述混合液中含有环己烯和金属氯化物催化剂。该方法采用金属氯化物催化剂与臭氧结合，实现了将环己烯选择性氧化为己二醛，克服了环己烯氧化反应中需使用贵金属配合物和高碘酸钠的缺点，通过采用微通道反应器，利用微反应器中高效的传质、传热效率，有效强化了两相物料间的物质传递，产物选择性可达93.5％。

Process for preparing camphor from borneol and isoborneol

Patent JPS50105841A

Process for the purification of ketones, obtained from the corresponding terpenes by ozonolysis and reduction

Purification of ketones (I) produced from terpenes by ozonolysis followed by reduction comprises steam-distilling the crude ketone at (sub)atmospheric pressure, extracting the distillate and distilling the extract.

Process for the preparation of monocarbonyl or biscarbonyl compounds

The invention relates to a process for the preparation of monocarbonyl or biscarbonyl compounds by reacting organic carbon compounds having one or more olefinic or aromatic double bonds in the molecule with the equivalent amount of ozone and by subsequently catalytically hydrogenating the ozonization products, wherein the peroxide-containing ozonization solution is fed continuously into a suspension of the hydrogenation catalyst in a lower aliphatic alcohol, while a peroxide content of not more than 0.1 mole/l is maintained, and the ozonization products are continuously cleaved reductively to give the corresponding carbonyl compounds.

Method of producing derivatives of glyoxal

Die Erfindung betrifft ein Verfahren zur Herstellung von Glyoxal, Alkylglyoxalen und von deren Acetalen durch Umsetzung von alpha-ß-ungesättigten Dialkylacetalen mit der äquivalenten Menge an Ozon und anschließender katalytischer Hydrierung der Ozonisierungsprodukte, wobei die peroxidhältige Ozonisierungslösung kontinuierlich unter Einhaltung eines Peroxidgehalts von maximal 0.1 Mol/l in eine Suspension des Hydrierkatalysators eingespeist und die Ozonisierungsprodukte reduktiv gespalten werden, worauf die bei der Hydrierung entstehenden Dialkylacetale gewünschtenfalls zu Glyoxal oder Alkylglyoxalen gespalten werden.

Preparation method and device of benzaldehyde

本发明公开了一种苯甲醛的制备方法及装置，该方法是以肉桂醛为原料，在臭氧化反应器中加入质量比为1:3的肉桂醛与无水乙醇的混合溶液，添加1.0~3.0 wt％的Ca(OH) 2 为催化剂，每克肉桂醛每小时通入质量为0.05~0.15 g的臭氧，在0°C下进行臭氧化反应1~10 h。在进行臭氧化反应的同时，控水装置通过蠕动泵产生压力差使乙醇和水透过反渗透膜进入除水管道，并在流经干燥剂后将除去水分的乙醇重新输送进臭氧化反应器，得到的粗产物经分子蒸馏处理后，可获得纯度达85％的天然苯甲醛。本发明的优点是：工艺装置新颖，操作简单，反应过程绿色化，制备苯甲醛纯度高，具有一定的发展潜力和工业价值。

Arylpiperazines having activity at the serotonin 1A receptor

A series of aryl piperazine compounds are effective pharmaceuticals for the treatment of conditions related to or affected by the serotonin 1 A receptor; the compounds are particularly effective antagonists at that receptor, and are particularly useful for alleviating the symptoms of nicotine and tobacco withdrawal.

Oxidative cleavage of unsaturated oils and products obtained therefrom

The invention provides a solid composite material comprising a matrix formed from a particulate or fibrous material and a cured thermosetting resin, wherein the cured thermosetting resin is derived from an oxidative cleavage product selected from aldehydes and peroxides and mixtures thereof formed by the oxidative cleavage of an unsaturated bond in an unsaturated plant or animal oil, other than the ozonolysis cleavage product of cashew nut shell liquid. Also provided is a process for the production of aldehydes and/or peroxides, which process comprises the treatment of a vegetable oil with ozone (e.g. in the presence of an alcohol as a solvent for the oil) so that hydroperoxides are produced, and the reductive cleavage of the hydroperoxides with a reducing sugar.

Prodn. of homogeneous catalyst - by adding acetone to fuel and then enriching with (poly)glyoxal

Prodn. of an homogeneous catalyst comprises adding acetone to a fuel and then enriching with glyoxal or poly:glyoxal.

Method for preparing aromatic ketone by oxidizing aromatic hydrocarbon with ozone

本发明属精细有机合成技术领域，针对芳烃合成芳酮类化合物的方法中存在的反应条件苛刻，催化剂制备工艺流程繁冗，副产物多且产率低等缺点，提供一种由臭氧氧化芳烃制备芳香酮的方法，以臭氧为氧化剂，芳烃为反应物，鼓泡搅拌釜或超重力旋转填料床为反应器，控制反应器内臭氧的气相浓度为10~200 mg/L，反应液温度为‑20℃‑50℃，反应10‑60min即可获得芳香酮类化合物。在不加入任何金属催化剂过程中，并在温和的反应条件下，将芳烃选择性氧化合成芳酮类化合物。工艺简单、高效绿环保色、反应条件温、转化率高、原子经济性高等优点。利于溶剂回收再利用。具有广阔的工业化应用前景。

Oxidation of polycyclic hydrocarbons

A method of producing an oxidation product of a polycyclic hydrocarbon by causing ozone to react with the polycyclic hydrocarbon and decomposing the ozonide so formed in which the ozonide is decomposed by treatment with aqueous pyridine. The resulting oxidation product is treated with potassium permanganate in high concentration to give the corresponding carboxylic acid. Preferably the permanganate is added in powder form and the treatment conducted at 60-65 DEG C. Specified cyclic hydrocarbons are phenanthrene, fluoranthrene, pyrene, benzanthracene, chrysene, picene, benzochrysene, dibenze phenanthrene and triphenylene. In an example a finely-dispersed stream of an ozone-oxygen mixture containing 10-15% by volume of ozone is passed through a solution of phenanthrene in chloroform at - 20 DEG C. until the amount of ozone absorbed is equivalent to one mol. per mol. of phenanthrene. The crude ozonide is then precipitated by the addition of light petroleum and is dissolved in equal parts of water and pyridine at 60-65 DEG C. and treated with potassium permanganate, in powder form or as a saturated aqueous solution, until the pink colour just persists. The mixture is boiled and filtered to remove manganese dioxide which is washed with warm pyridine followed by aqueous sodium carbonate; the alkaline liquor is then treated with charcoal and hydrochloric acid to give diphenic acid as a white powder; 2,21-diformyl bi-phenyl may be obtained from the pyridine solution if required by mixing with ether and extracting with hydrochloric acid. In other examples, 1,21-dicarboxy-2-phenyl-naphthalene; 2,21,6,61 - tetracarboxy - biphenyl; fluorenone - 1 - carboxylic acid; 2,211 - dicarboxy - p - terphenyl - 21,31 - dicarboxylic anhydride; 9 - carboxy - 10 - (21-carboxyphenyl) phenanthrene; 2,211,31,61-tetracarboxy - o - terphenyl; phenanthrene - 9,10-dicarboxylic anhydride; 21,3 - dicarboxy - 2 - phenyl naphthalene are produced respectively from chrysene, pyrene, fluoranthrene, picene ...

Hydrogenation of peroxidic ozonolysis products to carbonyl compounds using a monolith catalyst; apparatus therefor

Method and apparatus for the preparation of aldehydes

A method and an apparatus for producing aromatic aldehydes, including benzaldehyde and metatolualdehyde. Raw materials and a source of oxygen are fed into a tube reactor. The raw materials may be in a liquid or vapor phase. The reaction to form the aldehyde is catalyzed by suitable solid or liquid catalysts, including copper containing catalysts.

Preparation of carbonyl compounds

The invention relates to a process for the preparation of monocarbonyl or biscarbonyl compounds by reacting organic carbon compounds having one or more olefinic or aromatic double bonds in the molecule with the equivalent amount of ozone and by subsequently catalytically hydrogenating the ozonization products, wherein the peroxide-containing ozonization solution is fed continuously into a suspension of the hydrogenation catalyst in a lower aliphatic alcohol, while a peroxide content of not more than 0.1 mole/l is maintained, and the ozonization products are continuously cleaved reductively to give the corresponding carbonyl compounds.

Process for producing aromatic carbonyl compounds and peroxide compounds

Arylpiperazines having activity at the serotonin 1A receptor.

Ozonolysis operations for generation of reduced and/or oxidized product streams

The present invention relates to methods for safe and efficient use of hydrogen and oxygen in ozonolysis operations. The invention also relates to an ozonolysis process involving elements of both reductive and oxidative ozonolysis which are integrated in a continuous process. In one embodiment, the ozonolysis process of the present invention uses hydrogen and/or oxygen generated from water and electricity, which may be recycled to generate water and/or electricity.

ARYLIPIPERASINS WITH ACTIVITY WITH RESPECT TO 1A SEROTONIN RECEPTOR

Ряд соединений арилпиперазина являются эффективными фармацевтическими средствами для лечения состояний, связанных или зависимых от 1A-рецептора серотонина; эти соединения являются особенно эффективными антагонистами к этому рецептору и чрезвычайно полезны для купирования симптомов синдрома отмены никотина и табака.Международная заявка была опубликована вместе с отчетом о международном поиске. A number of arylpiperazine compounds are effective pharmaceuticals for treating conditions associated with or dependent on the 1A serotonin receptor; These compounds are particularly effective antagonists to this receptor and are extremely useful for alleviating the symptoms of nicotine and tobacco withdrawal syndrome. The international application was published along with an international search report.

Process for preparation of monocarbonyl or biscarbonyl compounds

The invention relates to a process for the preparation of monocarbonyl or biscarbonyl compounds by reacting organic carbon compounds having one or more olefinic or aromatic double bonds in the molecule with the equivalent amount of ozone and by subsequently catalytically hydrogenating the ozonization products, wherein the peroxide-containing ozonization solution is fed continuously into a suspension of the hydrogenation catalyst in a lower aliphatic alcohol, while a peroxide content of not more than 0.1 mole/l is maintained, and the ozonization products are continuously cleaved reductively to give the corresponding carbonyl compounds.

Guerbet alcohols and methods for preparing and using same

The invention relates to Guerbet alcohol precursors and Guerbet alcohols, as well as to processes for synthesizing them.

Oxidative cleavage of unsaturated oils and products obtained therefrom

The invention provides a solid composite material comprising a matrix formed from a particulate or fibrous material and a cured thermosetting resin, wherein the cured thermosetting resin is derived from an oxidative cleavage product selected from aldehydes and peroxides and mixtures thereof formed by the oxidative cleavage of an unsaturated bond in an unsaturated plant or animal oil, other than the ozonolysis cleavage product of cashew nut shell liquid. Also provided is a process for the production of aldehydes and/or peroxides, which process comprises the treatment of a vegetable oil with ozone (e.g. in the presence of an alcohol as a solvent for the oil) so that hydroperoxides are produced, and the reductive cleavage of the hydroperoxides with a reducing sugar.

Process for the preparation of glyoxal,alkylglyoxals and acetals thereof

Die Erfindung betrifft ein Verfahren zur Herstellung von Glyoxal, Alkylglyoxalen und von deren Acetalen durch Umsetzung von alpha-ß-ungesättigten Dialkylacetalen mit der äquivalenten Menge an Ozon und anschließender katalytischer Hydrierung der Ozonisierungsprodukte, wobei die peroxidhältige Ozonisierungslösung kontinuierlich unter Einhaltung eines Peroxidgehalts von maximal 0.1 Mol/l in eine Suspension des Hydrierkatalysators eingespeist und die Ozonisierungsprodukte reduktiv gespalten werden, worauf die bei der Hydrierung entstehenden Dialkylacetale gewünschtenfalls zu Glyoxal oder Alkylglyoxalen gespalten werden.

OZONID-REDUCING AGENT