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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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Форма поиска

Поддерживает ввод нескольких поисковых фраз (по одной на строку). При поиске обеспечивает поддержку морфологии русского и английского языка
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27-12-2012 дата публикации

Method for preparing acrolein from glycerol or glycerine

Номер: US20120330049A1
Автор: Benjamin Katryniok, Franck Dumeignil, Mickael Capron, Sebastien Paul
Принадлежит: Adisseo France SAS, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS, Universite De Lille 1 Sciences Et Technologies

The invention relates to a method for preparing acrolein from glycerol or glycerin, according to which dehydration of glycerol or glycerin is carried out in the presence of a catalyst which consists in at least one silica modified with zirconium dioxide, titanium dioxide or tungsten trioxide or any combination of these oxides, and a heteropolyacid. This method may be used for making 3-(methylthio)propionic aldehyde (MMP), 2-hydroxy-4-methylthiobutyronitrile (HMBTN), methionine or its analogs, from acrolein.

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Номер записи: 1
25-07-2013 дата публикации

TERPENOID DERIVATIVES OBTAINED FROM TERPENOIDS STEMING FROM RENEWABLE SOURCES

Номер: US20130190518A1
Автор: Caijo Frédéric, Crevisy Christophe, Mauduit Marc
Принадлежит: Ecole Nationale Superieure de Chimie de Rennes

The present invention relates to a process for preparing a terpenoid derivative, the process comprising a metathesis of an olefin and a terpenoid, and to terpenoid derivatives prepared with said process. 3. The process of claim 1 , wherein the terpenoid has only one double bond.4. The process of claim 1 , wherein the terpenoid has at least two double bonds.5. The process of claim 4 , the process further comprising oxidizing at least one allylic carbon of the terpenoid prior to the olefin metathesis.7. The process of claim 1 , wherein the olefin cross-metathesis is a catalyzed olefin cross-metathesis.8. The process of claim 7 , wherein the catalyst is a ruthenium Hoveyda type catalyst.11. A terpenoid derivative prepared by the process according to .14. The terpenoid derivative of claim 13 , wherein R claim 13 , R claim 13 , R claim 13 , Rare the same or different and are each independently hydrogen claim 13 , a lower alkyl claim 13 , aryl claim 13 , ketone claim 13 , ester claim 13 , ether claim 13 , amide claim 13 , or sulfonamide. Owing to both the decrease of the oil stocks and the rise of their price, and environmental aspects such as green house effect, research attention has recently been focused on the use of renewable resources isolated from agro-resources to produce various types of organic compounds, such as for example raw materials, intermediates, fine chemicals, organic polymers, and solvents (Monomers, polymers and composites from renewable resources, M. N. Belgacem and A. Gandini Eds; Elsevier, Amsterdam, 2008; A. Corma, S. Iborra, A. Velty, Chem. Rev. 2007, 107, 2411-2502.).Among the products that can be isolated from agro-resources, such as vegetable oils and sugars, terpenes and terpenoids appear particularly attractive. Terpenoids are a class of compounds formally assembled from terpene building blocks.The term “terpenes” is generally used to indicate compounds derived from five-carbon isoprene units, while the term “terpenoids” is generally used ...

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Номер записи: 2
15-08-2013 дата публикации

Process for preparing carboxamidine compounds

Номер: US20130211130A1
Автор: Jason Alan Mulder, Joe Ju GAO, Keith R. Fandrick, Nitinchandra D. Patel, Xingzhong Zeng
Принадлежит: BOEHRINGER INGELHEIM INTERNATIONAL GMBH

The present invention relates to a process of making a compound of formula (I): Wherein, R 1 , R 2 , R 4 and X are as defined herein.

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Номер записи: 3
07-11-2013 дата публикации

Novel Dihydroxybenzene Derivatives and Antiprotozoal Agent Comprising Same as Active Ingredient

Номер: US20130296422A1
Автор: Kita Kiyoshi, Saimoto Hiroyuki, Yabu Yoshisada, Yamamoto Masaichi
Принадлежит: ARIGEN PHARMACEUTICALS, INC.

Novel compounds below are useful for preventing or treating diseases caused by protozoans. At least one of a compound represented by Formula (I) 2. The compound claim 1 , optical isomer thereof claim 1 , and pharmaceutically acceptable salt thereof of claim 1 , wherein the one or more substituents of Rare each any one of —COOH claim 1 , —COORa (wherein Ra represents a Calkyl group) claim 1 , —CHO claim 1 , —COOCHCH(OH)CHOH claim 1 , —COO—CH—Rb (wherein Rb represents a group formed by removing one hydrogen atom on a carbon atom of aromatic hydrocarbons claim 1 , such as benzene claim 1 , naphthalene claim 1 , and anthracene) claim 1 , —O—CO-Rc (wherein Rc represents a Calkyl group) claim 1 , —OH claim 1 , —O-Rd (Rd represents a Calkyl group) claim 1 , —O—CH—O—CH claim 1 , —HET (HET represents a group formed by removing one hydrogen atom on a carbon or nitrogen atom of heterocyclic compounds) claim 1 , and —O-HET (HET is defined as above).4. The pharmaceutical composition of claim 3 , wherein the one or more substituents of Ris any one of —COOH claim 3 , —COORa (wherein Ra represents a Calkyl group) claim 3 , —CHO claim 3 , —COOCHCH(OH)CHOH claim 3 , —COO—CH—Rb (wherein Rb represents a group formed by removing one hydrogen atom on a carbon atom of aromatic hydrocarbons claim 3 , such as benzene claim 3 , naphthalene claim 3 , and anthracene) claim 3 , —O—CO-Rc (wherein Rc represents a Calkyl group) claim 3 , —OH claim 3 , —O-Rd (wherein Rd represents a Calkyl group) claim 3 , —O—CH—O—CH claim 3 , —HET (wherein HET represents a group formed by removing one hydrogen atom on a carbon or nitrogen atom of heterocyclic compounds) claim 3 , and —O-HET (wherein HET is defined as above).5. The pharmaceutical composition of or claim 3 , further comprising glycerol.7Trypanosoma.. The agent of claim 6 , wherein the protozoans is8Cryptosporidium.. The agent of claim 6 , wherein the protozoans is9. The agent of any one of to claim 6 , further comprising glycerol.11. The kit of ...

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Номер записи: 4
12-12-2013 дата публикации

GLP-1 POTENTIATORS FROM HEDYCHIUM CORONARIUM AND THEIR APPLICATIONS

Номер: US20130331323A1
Автор: Chen Hui-Ling, HUANG Jiann-Jyh, King K-Lim, Lee Shoei-Sheng, WU REY-YUH, Wu Yu-Yuan
Принадлежит: DEVELOPMENT CENTER FOR BIOTECHNOLOGY

A compound for controlling blood glucose level has a structure shown in Formula I: 5. A method for controlling blood glucose level claim 1 , comprising administering to a subject in need thereof the compound of .6. The method of claim 5 , further comprising administering to the subject a glucagon-like peptide-1 (GLP-1) receptor ligand to the subject.7. The method of claim 6 , wherein the GLP-1 receptor ligand is GLP-1 or exendin-4.8. The method of claim 6 , wherein the compound and the GLP-1 receptor ligand are administered together.10. The method of claim 9 , wherein the compound has a structure of 1A.11. The method of claim 9 , wherein the compound has a structure of 1B. 1. Technical Field of the InventionThe present invention relates to new uses of compounds, particularly a diterpenoid Galanal B, in the regulation of blood glucose levels.2. BackgroundGlucagon-like peptide-1 (GLP-1) analogues are a new class of hypoglycemic agents. GLP-1 is a member of the incretin family, which comprises gastrointestinal hormones that help control blood glucose levels after meals. GLP-1 exerts its functions by specific binding to GLP-1 receptor. GLP-1 receptor (GLP-1R) is widely distributed. In addition to pancreatic tissue, GLP-1 receptor is also distributed in the brain, lung, heart, kidney, etc. The wide distribution of this receptor contributes to the wide range of its functions.GLP-1 bind specifically to the GLP-1 receptor on the pancreatic beta cells. Activation of GLP-1R leads to stimulation of the adenylyl cyclase pathway, which eventually leads to increased insulin synthesis and release. In addition to the increased insulin synthesis and release, GLP-1 binding to its receptor also inhibits the production of glucagon and maintains constant levels of blood glucose after meals. Furthermore, GLP-1 also has a neuron regulatory function, which can delay gastric emptying and reduce appetite. At the same time, the hypoglycemic effect of GLP-1 is self-limiting and will not result ...

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Номер записи: 5
02-01-2020 дата публикации

Catalytic oxidation method and method for producing conjugated diene

Номер: US20200001262A1
Автор: Hiroki Hinoishi, Hiroshi Kameo, Kazuyuki IWAKAI, Tetsufumi Yamaguchi
Принадлежит: Mitsubishi Chemical Corp

An object of the present invention is to suppress performance deterioration of a molybdenum composite oxide-based catalyst at the time of performing gas-phase catalytic partial oxidation with molecular oxygen by using a tubular reactor. The present invention relates to a catalytic oxidation method using a tubular reactor in which a Mo compound layer containing a Mo compound and a composite oxide catalyst layer containing a Mo composite oxide catalyst are arranged in this order from a reaction raw material supply port side and under a flow of a mixed gas containing 75 vol % of air and 25 vol % of water vapor at 440° C., a Mo sublimation amount of the Mo compound is larger than a Mo sublimation amount of the Mo composite oxide catalyst under the same conditions.

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Номер записи: 6
11-01-2018 дата публикации

PROCESSES FOR THE PREPARATION OF COMPOUNDS, SUCH AS 3-ARYLBUTANALS, USEFUL IN THE SYNTHESIS OF MEDETOMIDINE

Номер: US20180009744A1
Автор: Eek Margus, Ekambaram Ramesh, Eklund Lars, Maasalu Ants
Принадлежит: CAMBREX KARLSKOGA AB

There is provided a process for the preparation of a compound of formula (I) as defined herein, wherein said process comprises reacting a compound of formula (II) as defined s herein with one or more suitable Vilsmeier reagent. 3. A process of claim 1 , wherein the Vilsmeier reagent is formed by reaction of dimethylformamide and POCl claim 1 , and optionally wherein dimethylformamide also acts as a solvent.5. A process of claim 1 , wherein the process is performed as a one-pot process and/or without isolation of a compound of formula IV.6. A process of claim 1 , further comprising isolating and optionally purifying the compound of formula I.9. A process of claim 7 , wherein the suitable reducing agent is a source of hydrogen and the reaction is performed in the presence of one or more suitable catalyst claim 7 , and optionally performed in the presence of one or more compound suitable for limiting the activity of said catalyst.10. A process of claim 7 , further comprising isolating and optionally purifying the compound of formula V.12. A compound of formula VI of .14. A process of claim 11 , wherein Z represents Na.17. A process of claim 15 , further comprising isolating and optionally purifying the compound of formula VIII.18. (canceled)19. A compound of claim 12 , wherein Z represents Na.20. A process of claim 13 , wherein Z represents Na. The present invention relates to new processes and new chemical compounds used in and obtained from such processes. In particular, it relates to new processes for the preparation of intermediates, such as 3-arylbutanals, useful in the synthesis of medetomidine.Compounds having a 3-arylbutanal core are particularly useful as intermediates in the production of medetomidine, which is a 4-substituted imidazole that is employed as the active ingredient in antifouling products such as Selektope™ and, in the form of the S enantiomer (known as dexmedetomidine), as a therapeutic agent.However, the synthesis of the 3-arylbutanal core ...

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Номер записи: 7
03-02-2022 дата публикации

2-(5-ISOPROPYL-2-METHYL-CYCLOHEX-2-EN- 1-YL-)ACETALDEHYDE AND 2-(6-ISOPROPYL- 3-METHYL-CYCLOHEX-2-EN-1-YL-) ACETALDEHYDE AS NEW ODORANTS

Номер: US20220033338A1
Автор: Gerstmann Frank, Hoelscher Bernd, Mansfeld Mark
Принадлежит:

The present invention relates to novel compounds of formula (I) 5. A mixture comprising (a) at least one compound of formula (II) or a stereoisomer thereof claim 2 , and (b) at least one compound of formula (III) or a stereoisomer thereof according to .10. A process for preparing a compound of formula (II) or a compound of formula (III) according to claim 6 , wherein the radical R of the vinyl ether (R—O) in step (i) is selected from the group consisting of linear C1 to C20 alkyl radical claim 6 , branched C1 to C20 alkyl radical claim 6 , cyclopentyl radical and cyclohexyl radical.11. A method of using at least one compound of the formula (I) or a stereoisomer thereof or a mixture of the compounds of the formula (I) or stereoisomers thereof according to claim 1 , comprising using the compound as a perfume or for the preparation of a perfume composition.12. A perfume or perfume preparation comprising at least one compound of formula (I) or a stereoisomer thereof according to .13. A perfume preparation according to claim 12 , further comprising one or more additional perfume(s) and/or aroma(s) claim 12 , wherein said one or more additional perfume(s) and/or aroma(s) is/are selected from one or more in the group of: extracts of natural raw materials claim 12 , preferably essential oils claim 12 , concretes claim 12 , absolues claim 12 , resins claim 12 , resinoids claim 12 , balsams claim 12 , tinctures and/or single odorants claim 12 , preferably from the group of hydrocarbons claim 12 , aliphatic alcohols claim 12 , aliphatic aldehydes and their acetals claim 12 , aliphatic ketones and their oximes claim 12 , aliphatic sulfur-containing compounds claim 12 , aliphatic nitriles claim 12 , esters of aliphatic carboxylic acids claim 12 , acyclic terpene alcohols claim 12 , acyclic terpene aldehydes and ketones claim 12 , cyclic terpene alcohols claim 12 , cyclic terpene aldehydes and ketones claim 12 , cyclic alcohols claim 12 , cycloaliphatic alcohols claim 12 , cyclic ...

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Номер записи: 8
24-01-2019 дата публикации

Composite Material Containing A Bismuth-Molybdenum-Nickel Mixed Oxide Or A Bismuth-Molybdenum-Cobalt Mixed Oxide And SIO2

Номер: US20190022629A1
Автор: Gabriele Donabauer, Gerhard Mestl, Inga Walzel, Magdalena Pritzl, Robert K. Grasselli, Silvia Neumann
Принадлежит: CLARIANT INTERNATIONAL LTD

The present invention relates to a process for producing a composite material and also the composite material itself. The composite material contains a bismuth-molybdenum-nickel mixed oxide or a bismuth-molybdenum-cobalt mixed oxide and a specific SiO2 as pore former. The present invention also relates to the use of the composite material according to the invention for producing a washcoat suspension and also a process for producing a coated catalyst using the composite material according to the invention. Furthermore, the present invention also relates to a coated catalyst which has a catalytically active shell comprising the composite material according to the invention on a support body. The coated catalyst according to the invention is used for preparing [alpha],[beta]-unsaturated aldehydes from olefins.

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Номер записи: 9
24-01-2019 дата публикации

NITROXIDE HYDROXYLAMINE AND PHENYLENEDIAMINE COMBINATIONS AS POLYMERIZATION INHIBITORS FOR ETHYLENICALLY UNSATURATED MONOMER PROCESSES

Номер: US20190023642A1
Автор: Tong David Youdong
Принадлежит: ECOLAB USA, Inc.

Polymerization inhibitor compositions are provided. The polymerization inhibitor compositions may include at least one hydroxylamine of a nitroxide and at least one phenylenediamine. Methods of inhibiting the unwanted polymerization of monomers are also provided. The methods include adding the presently disclosed polymerization inhibitor compositions to a fluid containing the monomers. The monomers may be ethylenically unsaturated monomers, such as acrylic acid, methacrylic acid, acrylonitrile, methacrylonitrile, acrolein, methacrolein, acrylate, methacrylate, acrylamide, methacrylamide, vinyl acetate, butadiene, ethylene, propylene, and styrene. 1. A method of inhibiting polymerization of butadiene comprising:adding an effective amount of a polymerization inhibitor composition to a fluid comprising butadiene, wherein the polymerization inhibitor composition comprises an effective amount of 4-hydroxy-2,2,6,6-tetramethyl piperidinol and an effective amount of N,N′-di-1,4-dimethylpentyl-1,4-phenylenediamine; andinhibiting polymerization of the butadiene.2. The method of claim 1 , wherein the effective amount of the 4-hydroxy-2 claim 1 ,2 claim 1 ,6 claim 1 ,6-tetramethyl piperidinol and the effective amount of the N claim 1 ,N′-di-1 claim 1 ,4-dimethylpentyl-1 claim 1 ,4-phenylenediamine is from about 1 ppm to about 2 claim 1 ,000 ppm by weight of monomer.3. The method of claim 1 , wherein the polymerization inhibitor composition is added continuously or intermittently to the fluid.4. The method of claim 1 , wherein the polymerization inhibitor composition is added during an ethylene manufacturing process.5. The method of claim 1 , wherein the polymerization inhibitor composition is added during a butadiene manufacturing process.6. A method of inhibiting polymerization of methacrylic acid claim 1 , comprising:adding an effective amount of a polymerization inhibitor composition to a fluid comprising the methacrylic acid, wherein the polymerization inhibitor composition ...

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Номер записи: 10
31-01-2019 дата публикации

PHOSPHINE SUBSTITUTED FERROCENYL COMPLEX

Номер: US20190031697A1
Автор: AZIZ Md. Abdul, HELAL Aasif, SHAIKH M. Nasiruzzaman
Принадлежит: KING FAHD UNIVERSITY OF PETROLEUM AND MINERALS

A functionalized magnetic nanoparticle including an organometallic sandwich compound and a magnetic metal oxide. The functionalized magnetic nanoparticle may be reacted with a metal precursor to fol in a catalyst for various C—C bond forming reactions. The catalyst may be recovered with ease by attracting the catalyst with a magnet. 2. (canceled)3. The complex of claim 1 , wherein Ris an optionally substituted alkyl.4. The complex of claim 1 , wherein Ris an optionally substituted aryl.5. The complex of claim 1 , wherein X is NH.620-. (canceled) This application claims the priority of the filing date of the U.S. Provisional Patent Application No. 62/406,449 filed Oct. 11, 2016, the disclosure of which is hereby incorporated herein by reference in its entirety.This project was funded by the National Plan for Science, Technology and Innovation (MAARIFAH)-King Abdulaziz City for Science and Technology through the Science and Technology Unit at King Fahd University of Petroleum and Minerals (KFUPM), the Kingdom of Saudi Arabia, award number 15-NAN4650-04.Aspects of this technology are described in an article “Magnetic nanoparticle-supported ferrocenylphosphine: a reusable catalyst for hydroformylation of alkene and Mizoroki-Heck olefination” by M. Nasiruzzaman Shaikh, Md. Abdul Aziz, Aasif Helal, Mohamed Bououdina, Zain H. Yamania, and Tae-Jeong Kim, in RSC Advances, 2016, pages 41687-41695, which is incorporated herein by reference in its entirety.The present disclosure relates to a functionalized magnetic nanoparticle including an organometallic sandwich compound and a functional group which can bind to a nanoparticle. The disclosure also relates to a magnetic catalyst which catalyzes C—C bond forming reactions such as hydroformylation and the Mizoroki-Heck coupling reaction.Carbon-carbon bond formation reactions mediated by various transition metals have emerged as increasingly important methodologies for the preparation of numerous organic building blocks for drugs, ...

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Номер записи: 11
30-01-2020 дата публикации

System For Suflide Treatment In Oilfield Systems

Номер: US20200031750A1
Автор: David O. Trahan
Принадлежит: Individual

A process for continuous, on-demand production of dilute acrolein liquid on-site, at or near the point of acrolein injection, by the liquid dehydration of glycerol in an improved tubular reactor where non-aqueous glycerol is combined with a heteropolyacid catalyst, including silicotungstic acid, phosphotungstic acid, or phosphomolybdic acid. The acid catalyst is evenly dissolved and dispersed in the glycerol upstream of the reactor vessel. The reaction is conducted in a tubular reactor which is heated to an elevated reaction temperature. The dilute acrolein produced in the tubular reactor is directed downstream, optionally through a liquid-liquid heat exchanger and then an air-liquid heat exchanger to reduce temperature, and then diluted prior to being injected into sulfide contaminated systems (such as oil & gas water floods, water disposal systems, producing oil wells, and fuel oil storage) via a pressure conduit.

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Номер записи: 12
30-01-2020 дата публикации

Process for the purification of acrolein

Номер: US20200031751A1
Автор: Bruno Krudewig, Haohao Zhu, Martin Koerfer, Michael Eicker, Rainer Malzkorn, Thorsten MERKER
Принадлежит: EVONIK DEGUSSA GmbH

The present invention relates to a process for purifying acrolein. The process includes the steps of a) splitting a liquid feed stream containing acrolein into at least a first liquid stream and a second liquid stream, b) introducing the first liquid stream with a temperature T 1 into a distillation column at a point between the top and the bottom of the distillation column, c) introducing the second liquid stream with a temperature T 2 into the distillation column at the top of the distillation column, d) withdrawing an overhead vapor stream enriched in acrolein from the distillation column, and e) withdrawing a bottom stream depleted in acrolein. The temperature T 2 of the second liquid stream in step c) is lower than the temperature T 1 of the first liquid stream in step b).

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Номер записи: 13
08-02-2018 дата публикации

Myricanol Derivatives and Uses Thereof for Treatment of Neurodegenerative Diseases

Номер: US20180037529A1
Автор: Baker Bill J., Calcul Laurent, Dickey Chad, Jinwal Umesh, Lebar Matthew
Принадлежит:

The subject invention pertains to myricanol derivatives, therapeutic compositions, and methods for treatment of neurodegenerative diseases, in particular, neurodegenerative diseases associated with abnormal accumulation of protein tau. 2. A compound according to claim 1 , having a chemical structure of formula A.3. A compound according to claim 1 , having a chemical structure of formula B.4. A compound according to claim 1 , having a chemical structure of formula C.7. A pharmaceutical composition comprising a compound of .8. A pharmaceutical composition comprising a compound of .9. A pharmaceutical composition comprising a compound of .11. The method according to claim 10 , wherein the compound has a chemical structure of formula G.12. The method according to claim 10 , wherein the compound has a chemical structure of formula B.13. The method according to claim 10 , wherein the compound has a chemical structure of formula H.16. The method according to claim 10 , wherein the cells are in a subject in need of treatment for a neurodegenerative disease.17. The method of claim 16 , wherein the neurodegenerative disease is a tauopathy.18. The method of claim 17 , wherein the subject is a human.19. The method of claim 18 , wherein the neurodegenerative disease is selected from Alzheimer's disease claim 18 , Parkinson's disease claim 18 , frontotemporal dementia claim 18 , frontotemporal dementia with Parkinsonism claim 18 , frontotemporal lobe dementia claim 18 , pallidopontonigral degeneration claim 18 , progressive supranuclear palsy claim 18 , multiple system tauopathy claim 18 , multiple system tauopathy with presenile dementia claim 18 , Wilhelmsen-Lynch disease claim 18 , Pick's disease claim 18 , or Pick's disease-like dementia.20. The method of claim 19 , wherein the neurodegenerative disease is Alzheimer's disease. This application is a continuation of U.S. application Ser. No. 14/390,960, filed Oct. 6, 2014; which is the U.S. national stage application of ...

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Номер записи: 14
08-02-2018 дата публикации

PERFUME SYSTEMS

Номер: US20180037843A1
Автор: Denutte Hugo Robert Germain, Pintens An, Smets Johan, VAN AKEN Koen, Vrielynck Freek Annie Camiel
Принадлежит:

The present application relates to perfume raw materials, perfume delivery systems and consumer products comprising such perfume raw materials and/or such perfume delivery systems, as well as processes for making and using such perfume raw materials, perfume delivery systems and consumer products. Such perfume raw materials and compositions, including the delivery systems, disclosed herein expand the perfume communities' options as such perfume raw materials can provide variations on character and such compositions can provide desired odor profiles. 1. A perfume raw material selected from Table 1 Nos. (S)-2 ,2-dimethyl-3-(4-(prop-1-en-2-yl)cyclohex-1-enyl)propanenitrile; 3-cyclopropyl-2-(cyclopropylmethyl)-2-methylpropanenitrile; 1-(cyclopropylmethyl)cyclo-propanecarbonitrile; (S)-3 ,3-dimethyl-4-(4-(prop-1-en-2-yl)cyclohex-1-enyl)butan-2-one; 3 ,3-dimethyl-4-((S)-4-(prop-1-en-2-yl)cyclohex-1-enyl)butan-2-(R ,S)-ol; (S)-2 ,2-dimethyl-3-(4-(prop-1-en-2-yl)cyclohex-1-enyl)propanal; 3-cyclopropyl-2-(cyclo-propylmethyl)-2-methylpropanal; 3-cyclopropyl-2-(cyclopro-pylmethyl)-2-methylpropan-1-ol; (S)-2 ,2-dimethyl-3-(4-(prop-1-en-2-yl)cyclohex-1-enyl)propan-1-ol; (R ,S)-2 ,2-di(cyclohex-2-enyl)propanenitrile; 1-cyclopropyl-2-(cyclopropylme-thyl)-2 ,4-(R ,S)-dimethylhexan-3-one; 1-(1-(cyclopropyl-methyl)cyclopropyl)ethanone; 1-(1-(cyclopropylmethyl)-cyclopropyl)pentan-1-one; 2-methyl-2-((1R ,S)(5R)-2-methyl-5-(prop-1-en-2-yl)cyclohex-2-enyl)propanenitrile; 1-(1-(cyclopropylmethyl)-cyclopropyl)pentan-1-(R ,S)ol; 3-((1R ,5S)-6 ,6-dimethylbicyclo[3.1.1]hept-2-en-2-yl)propanenitrile; (2R ,S)-3-((1R ,5S)-6 ,6-dimethylbicyclo[3.1.1]hept-2-en-2-yl)-2-methylpropanenitrile; 1-(((1R ,5S)-6 ,6-dimethyl-bicyclo[3.1.1]hept-2-en-2-yl)-methyl)cyclobutanecarbonitrile; 4-allyl-4-methylnon-1-en-5-one; 4-allyl-4-methylnon-1-en-5-(R ,S)-ol; iso-butyl 2 ,5-dimethylhex-4-enoate; 7-cyclopentylideneheptan-2-one; 8-cyclopentylideneoctan-3-one; (E/Z)-11-methyldodec-8-en-3-one (9:1—E:Z); (E/Z)-10- ...

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Номер записи: 15
18-02-2016 дата публикации

Composite Material Containing A Bismuth-Molybdenum-Nickel Mixed Oxide Or A Bismuth-Molybdenum-Cobalt Mixed Oxide And SIO2

Номер: US20160045900A1
Автор: DONABAUER Gabriele, GRASSELL Robert, MESTL Gerhard, NEUMANN Silvia, PRITZI Magdalena, WALZEL Inga
Принадлежит: CLARIANT INTERNATIONAL LTD.

The present invention relates to a process for producing a composite material and also the composite material itself. The composite material contains a bismuth-molybdenum-nickel mixed oxide or a bismuth-molybdenum-cobalt mixed oxide and a specific SiO2 as pore former. The present invention also relates to the use of the composite material according to the invention for producing a washcoat suspension and also a process for producing a coated catalyst using the composite material according to the invention. Furthermore, the present invention also relates to a coated catalyst which has a catalytically active shell comprising the composite material according to the invention on a support body. The coated catalyst according to the invention is used for preparing [alpha],[beta]-unsaturated aldehydes from olefins. 1. A process for producing a composite material , comprising the steps of:(a) preparing a first aqueous solution containing salts of bismuth and of nickel or of bismuth and of cobalt;(b) preparing a second aqueous solution containing a molybdenum compound and optionally a binder;(c) adding the first aqueous solution to the second aqueous solution, forming a first suspension;{'sub': '2', '(d) adding a second suspension to the first suspension to form a third suspension, the second suspension containing SiOwhich has a pore volume in the range from 0.1 to 10 ml/g and an average particle size in the range from 3 to 20 μm; and'}(e) spray-calcining the third suspension at a temperature in the range from 200 to 600° C., to give the composite material containing a bismuth-molybdenum-nickel mixed oxide or bismuth-molybdenum-cobalt mixed oxide.2. The process as claimed in claim 1 , wherein in step (a) the first aqueous solution further comprises a salt of magnesium claim 1 , a salt of iron or a combination thereof.3. The process as claimed in claim 1 , wherein in step (a) the first aqueous solution contains a potassium compound.4. The process as claimed in claim 1 , ...

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Номер записи: 16
19-02-2015 дата публикации

Aldehydes as perfuming ingredients

Номер: US20150051133A1
Автор: Robert Moretti
Принадлежит: FIRMENICH SA

An aldehyde of formula (I) in the form of any one of its stereoisomers or a mixture thereof, wherein each dotted line, independently from each other, represents a single or double bond; n is 0 or 1; R 1 is a hydrogen atom or a methyl group; R 2 is a hydrogen atom or a methyl or ethyl group; and R 3 , which can be present in any of positions 2 to 6 of the cyclic moiety, is a hydrogen atom or a methyl or ethyl group, or a CH 2 group bridging positions 3 and 6. Also, the use of the aldehyde as perfuming ingredient to impart odor notes of the aldehyde, lily of the valley type.

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Номер записи: 17
19-02-2015 дата публикации

Myricanol Derivatives and Uses Thereof for Treatment of Neurodegenerative Diseases

Номер: US20150051294A1
Автор: Baker Bill J., Calcul Laurent, Dickey Chad, Jinwal Umesh
Принадлежит: Universtiy of South Florida

The subject invention pertains to myricanol derivatives, therapeutic compositions, and methods for treatment of neurodegenerative diseases, in particular, neurodegenerative diseases associated with abnormal accumulation of protein tau. 2. A compound according to claim 1 , having a chemical structure of formula A.3. A compound according to claim 1 , having a chemical structure of formula B.4. A compound according to claim 1 , having a chemical structure of formula C.7. A pharmaceutical composition comprising a compound of .8. A pharmaceutical composition comprising a compound of .9. A pharmaceutical composition comprising a compound of .11. The method according to claim 10 , wherein the compound has a chemical structure of formula A.12. The method according to claim 10 , wherein the compound has a chemical structure of formula B.13. The method according to claim 10 , wherein the compound has a chemical structure of formula C.16. The method according to claim 10 , wherein the cells are in a subject in need of treatment for a neurodegenerative disease.17. The method of claim 16 , wherein the neurodegenerative disease is a tauopathy.18. The method of claim 17 , wherein the subject is a human.19. The method of claim 18 , wherein the neurodegenerative disease is selected from Alzheimer's disease claim 18 , Parkinson's disease claim 18 , frontotemporal dementia claim 18 , frontotemporal dementia with Parkinsonism claim 18 , frontotemporal lobe dementia claim 18 , pallidopontonigral degeneration claim 18 , progressive supranuclear palsy claim 18 , multiple system tauopathy claim 18 , multiple system tauopathy with presenile dementia claim 18 , Wilhelmsen-Lynch disease claim 18 , Pick's disease claim 18 , or Pick's disease-like dementia.20. The method of claim 19 , wherein the neurodegenerative disease is Alzheimer's disease. This application claims the benefit of U.S. provisional application Ser. No. 61/621,278, filed Apr. 6, 2012, and U.S. provisional application Ser. No. ...

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Номер записи: 18
25-02-2016 дата публикации

PERFUME COMPOSITIONS CONTAINING ISOMERIC ALKADIENALS

Номер: US20160052855A1
Автор: ANSARI Hifzur R., BEDOUKIAN Robert H., PESAK Douglas Jay, Swierczek Krzysztof
Принадлежит:

A perfume composition comprising an effective amount of at least one alkadienal selected from 4,8-undecadienal and isomers thereof, 4,9-dodecadienal and isomers thereof, and 4,10-tridecadienal and isomers thereof. The isomers of 4,8-undecadienal comprise Z,Z-4,8-undecadienal, E,E-4,8-undecadienal, and mixed Z/E isomers of 4,8-undecadienal; the isomers of 4,9-dodecadienal comprise Z,Z-4,9-dodecadienal, E,E-4,9-dodecadienal, and mixed Z/E isomers of 4,9-dodecadienal; and the isomers of 4,10-tridecadienal comprise Z,Z-4,10-tridecadienal, E,E-4,10-tridecadienal, and mixed Z/E isomers of 4,10-tridecadienal. A composition comprising an effective amount of at least one alkadienal selected from 4,8-undecadienal and isomers thereof, 4,9-dodecadienal and isomers thereof, and 4,10-tridecadienal and isomers thereof. Processes for the preparation of the isomer mixtures of alkadienals are provided. The isomeric alkadienals have a range of fresh, watery, ozone, grapefruit, tangerine, orange peel, aldehydic notes of exceptional strength. 1. A composition comprising an alkadienal selected from the group consisting 4 ,8-undecadienal and isomers thereof , 4 ,9-dodecadienal and isomers thereof , and 4 ,10-tridecadienal and isomers thereof.2. The composition of which is a fragrance composition or a flavor composition.3. The composition of wherein the isomers of 4 claim 1 ,8-undecadienal comprise Z claim 1 ,Z-4 claim 1 ,8-undecadienal claim 1 , E claim 1 ,E-4 claim 1 ,8-undecadienal claim 1 , and mixed Z/E isomers of 4 claim 1 ,8-undecadienal; the isomers of 4 claim 1 ,9-dodecadienal comprise Z claim 1 ,Z-4 claim 1 ,9-dodecadienal claim 1 , E claim 1 ,E-4 claim 1 ,9-dodecadienal claim 1 , and mixed Z/E isomers of 4 claim 1 ,9-dodecadienal; and the isomers of 4 claim 1 ,10-tridecadienal comprise Z claim 1 ,Z-4 claim 1 ,10-tridecadienal claim 1 , E claim 1 ,E-4 claim 1 ,10-tridecadienal claim 1 , and mixed Z/E isomers of 4 claim 1 ,10-tridecadienal.4. The composition of wherein the isomers ...

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Номер записи: 19
08-05-2014 дата публикации

Microorganisms and methods for production of specific length fatty alcohols and related compounds

Номер: US20140127765A1
Автор: Anthony P. Burgard, Robin E. Osterhout
Принадлежит: Genomatica Inc

The invention provides non-naturally occurring microbial organisms containing a fatty alcohol, fatty aldehyde or fatty acid pathway, wherein the microbial organisms selectively produce a fatty alcohol, fatty aldehyde or fatty acid of a specified length. Also provided are non-naturally occurring microbial organisms having a fatty alcohol, fatty aldehyde or fatty acid pathway, wherein the microbial organisms further include an acetyl-CoA pathway. In some aspects, the microbial organisms of the invention have select gene disruptions or enzyme attenuations that increase production of fatty alcohols, fatty aldehydes or fatty acids. The invention additionally provides methods of using the above microbial organisms to produce a fatty alcohol, a fatty aldehyde or a fatty acid.

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Номер записи: 20
13-02-2020 дата публикации

RESTARTING METHOD

Номер: US20200048175A1
Автор: Kawamura Tomoyuki, Kobayashi Tomoaki, Kurakami Tatsuhiko, Yoshida Hideo
Принадлежит: Nippon Kayaku Kabushiki Kaisha

A method for producing at least one oxidation product selected from the group consisting of acrolein and acrylic acid is provided. This method can alleviate concerns about deterioration of a gas-phase oxidation catalyst and reaction runaway in a restart period after a shutdown, and can allow the reaction to proceed in a stable state. Using a fixed-bed reactor filled with a gas-phase oxidation catalyst, at least one source gas selected from the group consisting of propylene and acrolein is subjected to a gas-phase contact oxidation reaction while a heating medium is caused to contact with or circulate through the fixed-bed reactor and thereby to heat the fixed-bed reactor. The temperature of the heating medium when the load is maximum in the restart period after the shutdown is controlled to be lower than the temperature of the heating medium when the load is maximum in an initial start-up period. 1. A method for producing at least one oxidation product selected from the group consisting of acrolein and acrylic acid , with use of a fixed-bed reactor filled with a gas-phase oxidation catalyst , by subjecting at least one source gas selected from the group consisting of propylene and acrolein to a gas-phase contact oxidation reaction while causing a heating medium to contact with or circulate through the fixed-bed reactor and thereby heating the fixed-bed reactor ,wherein a temperature of the heating medium when a load is maximum in a restart period after a shutdown is controlled to be lower than a temperature of the heating medium when a load is maximum in an initial start-up period.2. The method for producing an oxidation product according to claim 1 , wherein production of the oxidation product is restarted after the shutdown within 9000 hours after an initial start-up of the reaction.4. The method for producing an oxidation product according to claim 1 ,wherein the fixed-bed reactor is a multistage fixed-bed reactor which is equipped with a first fixed-bed reactor ...

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Номер записи: 21
22-02-2018 дата публикации

Method for producing methylmethacrylate

Номер: US20180050977A1
Автор: Alexander Lygin, Martin Koestner, Matthias Groemping, Rudolf Burghardt, Steffen Krill, Torsten Balduf
Принадлежит: Evonik Roehm GmbH

The present invention relates to a process for producing methyl methacrylate, comprising the following steps: A) producing methacrolein and B) reacting the methacrolein obtained in step A) in an oxidative esterification reaction to give methyl methacrylate, characterized in that the two steps A) and B) take place in a liquid phase at a pressure of from 2 to 100 bar, and step B) is carried out in the presence of a heterogeneous noble-metal-containing catalyst comprising metals and/or comprising metal oxides.

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Номер записи: 22
26-02-2015 дата публикации

NOVEL ORGANOLEPTIC COMPOUNDS

Номер: US20150057207A1
Автор: Amorelli Benjamin, Arruda Edward Mark, BELKO Robert P., Cai Tingwei, Closson Adam P., Giffin Nicole L., Mertz Gary J., Monteleone Michael G.
Принадлежит:

The present invention relates to novel compounds and their use as fragrance materials. 1. A compound selected from the group consisting of:1,1-diethyl-4,6-dimethyl-1,3,3a,4,7,7a-hexahydro-isobenzofuran;1,1-diethyl-4,6-dimethyl-1,3,3a,6,7,7a-hexahydro-isobenzofuran;1,1-diethyl-5,7-dimethyl-1,3,3a,4,5,7a-hexahydro-isobenzofuran;1,1-diethyl-5,7-dimethyl-1,3,3a,4,7,7a-hexahydro-isobenzofuran;cyclopentadecanone;cyclopentadec-3-enone;5-methyl-hept-5-enal;2,4-dimethyl-hex-4-enal;2,4,8-trimethyl-deca-4,9-dienal;5-ethyl-3-methylhexahydro-1-benzofuran-2(3H)-one;6-ethyl-3-methylhexahydro-1-benzofuran-2(3H)-one;methyl-2-(propan-2-yl)cyclohexyl carbonate;2-[3-methoxy-2-propen-1-yl]-6,6-dimethyl-bicyclo[3.1.1]hept-2-ene;but-2-enoic acid 1-cyclopentyl-ethyl ester;1,2,4-trimethyl-cyclohex-3-enecarboxylic acid ethyl ester;1,3,5-trimethyl-cyclohex-3-enecarboxylic acid ethyl ester;13-methyl-3a,4,5,6,7,8,9,10,11,13a-decahydro-1H,3H-2-oxa-cyclopentacyclododecene;and a mixture thereof.2. A fragrance formulation containing an olfactory acceptable amount of a compound selected from the group consisting of:1,1-diethyl-4,6-dimethyl-1,3,3a,4,7,7a-hexahydro-isobenzofuran;1,1-diethyl-4,6-dimethyl-1,3,3a,6,7,7a-hexahydro-isobenzofuran;1,1-diethyl-5,7-dimethyl-1,3,3a,4,5,7a-hexahydro-isobenzofuran;1,1-diethyl-5,7-dimethyl-1,3,3a,4,7,7a-hexahydro-isobenzofuran;cyclopentadecanone;cyclopentadec-3-enone;5-methyl-hept-5-enal;2,4-dimethyl-hex-4-enal;2,4,8-trimethyl-deca-4,9-dienal;5-ethyl-3-methylhexahydro-1-benzofuran-2(3H)-one;6-ethyl-3-methylhexahydro-1-benzofuran-2(3H)-one;methyl-2-(propan-2-yl)cyclohexyl carbonate;2-[3-methoxy-2-propen-1-yl]-6,6-dimethyl-bicyclo[3.1.1]hept-2-ene;but-2-enoic acid 1-cyclopentyl-ethyl ester;1,2,4-trimethyl-cyclohex-3-enecarboxylic acid ethyl ester;1,3,5-trimethyl-cyclohex-3-enecarboxylic acid ethyl ester;13-methyl-3a,4,5,6,7,8,9,10,11,13a-decahydro-1H,3H-2-oxa-cyclopentacyclododecene;and a mixture thereof.3. The fragrance formulation of claim 2 , wherein the ...

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Номер записи: 23
15-05-2014 дата публикации

Hydroformylation method having improved catalyst stability in reaction

Номер: US20140135533A1
Автор: Dae-Chul Kim, Dong-Hyun Ko, Jae-Hui Choi, Moo-Ho Hong, O-Hak Kwon, Sung-Shik Eom
Принадлежит: LG Chem Ltd

Disclosed is a hydroformylation method having improved catalyst stability in a reaction. Advantageously, provided is a hydroformylation method in which a specific α,β-unsaturated carbonyl compound is incorporated during a hydroformylation reaction to prevent alkyl phosphite decomposed from a phosphite ligand from acting as a catalyst poison, thereby improving a yield of reaction and inhibiting decomposition of ligand and catalyst.

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Номер записи: 24
02-03-2017 дата публикации

NOVEL GLYCEROL DEHYDRATION METHODS AND PRODUCTS THEREOF

Номер: US20170057898A1
Автор: Ye Xiaofei
Принадлежит:

Methods and systems for suppressing coking in dehydration reactions catalyzed by solid acids. Dehydration reactions catalyzed by one or more solid acid catalysts can be performed in the presence of a super critical carbon dioxide medium which prevents or minimizes coking of the solid acid catalysts. Methods and systems are provided for producing glycerol products, such as acrolein, acrylic acid, acetol, by performing a dehydration reaction of glycerol using one or more solid acid catalysts in the presence of a super critical carbon dioxide reaction medium. Such methods and systems can be nm for extended periods of time, or continuously, due to catalyst regeneration and/or recycling. Such methods and systems are configured to produce glycerol products from crude glycerol feedstock with minimal pretreatment. 1. A method for producing a glycerol product , comprising exposing glycerol to a solid acid catalyst in a supercritical or subcritical carbon dioxide (SCF CO) reaction medium , whereby a glycerol product is produced by solid acid catalyzed dehydration of the glycerol.2. The method of claim 1 , wherein coking of the solid acid catalyst is decreased during the solid acid catalyzed dehydration of the glycerol in the presence of SCF COas compared to solid acid catalyzed dehydration of glycerol in the absence of an SCF COreaction medium.3. The method of claim 1 , wherein the active lifetime of the catalyst is extended as compared to the active lifetime of the catalyst during glycerol dehydration in a reaction medium other than SCF CO.4. The method of claim 1 , wherein the glycerol product is selected from the group consisting of acrolein claim 1 , acrylic acid claim 1 , acetol and combinations thereof.5. The method of claim 1 , wherein the solid acid catalyst is selected from the group consisting of heteropoly acids claim 1 , salts of heteropoly acids claim 1 , zeolites claim 1 , metal oxides claim 1 , cation-exchange resins claim 1 , carbonaceous solid acids claim 1 , ...

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Номер записи: 25
04-03-2021 дата публикации

Process for preparing 4-penten-2-ynal

Номер: US20210061745A1
Автор: Naoki Ishibashi, Takeshi Kinsho, Yuki Miyake
Принадлежит: Shin Etsu Chemical Co Ltd

A process for preparing 4-penten-2-ynal of the following formula (2): CH 2 ═CHC≡CCHO  (2) the process comprising a step of hydrolyzing a 5,5-dialkoxy-1-penten-3-yne compound of the following general formula (1): CH 2 ═CHC≡CCH(OR 1 )(OR 2 )  (1) wherein R 1 and R 2 represent, independently of each other, a monovalent hydrocarbon group having 1 to 15 carbon atoms, preferably 1 to 8, more preferably 1 to 4, or R 1 and R 2 may be bonded to each other to form a divalent hydrocarbon group, R 1 -R 2 , having from 2 to 10 carbon atoms, to obtain 4-penten-2-ynal (2).

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Номер записи: 26
22-05-2014 дата публикации

Novel Fragrance Compounds

Номер: US20140142343A1
Автор: Anne Dominique Fortineau
Принадлежит: Givaudan Nederland Services BV

A compound having the structure wherein R is hydrogen or methyl, having a strong odour and for use as a perfumery ingredient.

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Номер записи: 27
27-02-2020 дата публикации

Process for preparing (e2,z6)-2,6-nonadienal

Номер: US20200062682A1
Автор: Miyoshi Yamashita, Takeshi Kinsho, Yuki Miyake
Принадлежит: Shin Etsu Chemical Co Ltd

The object of the present invention is to provide an industrial and economical process for preparing (E2,Z6)-2,6-nonadienal of the following formula (4): The present invention provides a process for preparing (E2,Z6)-2,6-nonadienal (4), comprising at least steps of: subjecting (Z3,Z6)-3,6-nonadien-1-ol of the following formula (1): to oxidation with a sulfoxide compound of the following formula (2): CH 3 (R′)S═O  ( 2 ) in which R 1 represents a monovalent hydrocarbon group having from 1 to 12 carbon atoms, in the presence of a sulfur trioxide complex and an amine compound of the following formula (3): N(R 2 )(R 3 )(R 4 )  ( 3 ) in which R 2 , R 3 , and R 4 each independently represent a monovalent hydrocarbon group having from 1 to 12 carbon atoms, or R 3 and R 4 may be bonded to each other to form a divalent hydrocarbon group having from 3 to 12 carbon atoms, R 3 -R 4 , to form the aforesaid (E2,Z6)-2,6-nonadienal (4).

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Номер записи: 28
27-02-2020 дата публикации

FRAGRANCE AND FLAVOR MATERIALS

Номер: US20200063062A1
Автор: Blandino Maureen, Lankin Michael E.
Принадлежит: TAKASAGO INTERNATIONAL CORPORATION

The present disclosure is directed to the synthesis and application of undecavertol derivatives having unique and desired flavor and/or fragrant characteristics. The compounds of the present disclosure can be employed alone or incorporated as fragrance or flavor ingredients in fragrance or flavor compositions. The present disclosure is also directed to consumer products comprising such derivatives and/or fragrance or flavor compositions. 4. (canceled)5. A fragrance or flavor composition comprising one or more compounds of .6. A consumer product containing the flavor or fragrance composition of .7. A fragrance or flavor composition comprising one or more compounds of .8. A fragrance or flavor composition comprising one or more compounds of .9. A consumer product containing the flavor or fragrance composition of .10. A consumer product containing the flavor or fragrance composition of . The present application claims priority to U.S. Provisional Application No. 62/438,374, filed on Dec. 22, 2016, the content of which is incorporated herein by reference in its entirety.The present application relates to compounds useful as fragrance or flavor components in fragrance or flavor compositions.There is a continuing interest in the preparation of synthetic fragrance and flavor components and their use in consumer products. One strategy to prepare such compounds is to apply a known synthetic chemical reaction to readily available substrates. The Claisen Rearrangement is a reaction known to one skilled in the art of organic synthesis. When an allylic alcohol is converted to the vinyl ether and treated with acid and heat, the vinyl ether rearranges to a 4-alkenal. There are several Claisen products known for their use in the flavor and fragrance industry (Nowicki, Molecules 2000, 1033-1050). A similar rearrangement is the Johnson Rearrangement, also known to one skilled in the art, whereby an allylic alcohol is converted to a 4-alkenoic ester.There remains a need and demand for ...

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Номер записи: 29
17-03-2016 дата публикации

Organic compounds

Номер: US20160075627A1
Автор: Andreas Goeke, Francis VOIROL, Heike LAUE, Philip Kraft, Yue Zou
Принадлежит: Givaudan SA

An aryl-substituted alkanal compound having a molecular weight of less than 300 g/mol and which bears a substituent on the aryl ring ortho to a substituent bearing the aldehyde functionality. Said compounds are useful as perfume ingredients in personal care and household care products.

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Номер записи: 30
05-03-2020 дата публикации

CYCLOHEXENE DERIVATIVES AS PERFUMING INGREDIENTS

Номер: US20200071253A1
Автор: BIRKBECK Anthony Alexander
Принадлежит:

The present invention concerns a compound of formula (I) in the form of any one of its stereoisomers or a mixture thereof, and wherein n is 0 or 1; R and R′, independently from each other, represent a hydrogen atom or a Clinear alkyl group provided that one of said groups represents a hydrogen atom and the other a Clinear alkyl group; each R, independently from each other, represents a hydrogen atom or a methyl group; and Rand Rrepresent, independently of each other, a Clinear alkyl group; or Rand R, when taken together, represent a Clinear, branched alkanediyl or alkenediyl. The use of compound of formula (I) as perfuming ingredients of floral type and the invention's compounds as part of a perfuming composition or of a perfuming consumer product are also part of the present invention. 2. The compound according to claim 1 , characterized in that n is 0.3. The compound according to claim 1 , characterized in that Ris hydrogen atom.5. The compound according to claim 1 , characterized in that Ris a methyl group.6. The compound according to claim 1 , characterized in that Ris a methyl group.7. The compound according to claim 1 , characterized in that Rand R claim 1 , when taken together claim 1 , are a Clinear alkanediyl.8. The compound according to claim 1 , characterized in that R and R′ claim 1 , independently from each other claim 1 , represent a hydrogen atom or a methyl group provided that one of said groups represents a hydrogen atom and the other a methyl group.9. The compound according to claim 1 , characterized in that the compound of formula (I) is a mixture comprising 3-(4-isopropyl-6-methyl-1-cyclohexen-1-yl)propanal and 3-(4-isopropyl-2-methyl-1-cyclohexen-1-yl)propanal.10. A method to confer claim 1 , enhance claim 1 , improve or modify the odor properties of a perfuming composition or of a perfumed article claim 1 , which method comprises adding to said composition or article an effective amount of at least one compound of formula (I) as defined in .11. ...

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Номер записи: 31
14-03-2019 дата публикации

METHOD FOR PRODUCING METHYLMETHACRYLATE

Номер: US20190077742A1
Автор: Balduf Torsten, BURGHARDT Rudolf, Groemping Matthias, KOESTNER Martin, KRILL Steffen, LYGIN Alexander
Принадлежит: Evonik Roehm GmbH

The present invention relates to a process for producing methyl methacrylate, comprising the following steps: A) producing methacrolein and B) reacting the methacrolein obtained in step A) in an oxidative esterification reaction to give methyl methacrylate, characterized in that the two steps A) and B) take place in a liquid phase at a pressure of from 2 to 100 bar, and step B) is carried out in the presence of a heterogeneous noble-metal-containing catalyst comprising metals and/or comprising metal oxides. 1. A process for producing methyl methacrylate , the process comprising:A) producing methacrolein from propanal and formaldehyde andB) reacting the methacrolein in an oxidative esterification reaction to obtain methyl methacrylate, whereinthe producing A) and the reacting B) take place in a liquid phase at a pressure of from 2 to 100 bar, andthe reacting B) is carried out in the presence of a heterogeneous noble-metal-comprising catalyst comprising at least one selected from the group consisting of gold and nickel.2. The process according to claim 1 , wherein the producing A) is carried out in the presence of from 0.1 to 20 mol % of organic base and from 0.1 to 20 mol % of acid claim 1 , based in each case on propanal.3. The process according to claim 1 , wherein the producing A) is carried out at a temperature of from 100 to 300° C.4. The process according to claim 1 , wherein the producing A) is carried out at a pressure of from 5 to 100 bar.5. The process according to claim 1 , wherein the heterogeneous oxidation catalyst comprises one or more ultra-finely dispersed metals with an average particle size of <20 nm selected from the group consisting of gold and nickel.6. (canceled)7. The process according to claim 2 , wherein the organic base comprises a secondary amine.8. The process according to claim 2 , wherein the acid comprises at least one organic acid.9. The process according to claim 2 , wherein a molar ratio of the acid to the organic base ranges from ...

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Номер записи: 32
22-03-2018 дата публикации

Carbidopa and L-Dopa Prodrugs and Methods of use

Номер: US20180079762A1
Автор: CARDINAL-DAVID Benoit, Chan Vincent S., Dempah Kassibla, ENRIGHT Brian P., Henry Rodger F., HO Raimundo, HUANG Ye, HUTERS Alexander D., KLIX Russell C., KRABBE Scott W., Kym Philip R., Lao Yanbin, Lou Xiaochun, MACKEY Sean E., MATULENKO Mark A., MAYER Peter T., MILLER Christopher P., STAMBULI James, Stella Valentino J., Voight Eric A., Wang Zhi, ZHANG Geoff G.
Принадлежит: AbbVie Inc.

The present disclosure relates to (a) carbidopa prodrugs, (b) pharmaceutical combinations and compositions comprising a carbidopa prodrug and/or an L-dopa prodrug, and (c) methods of treating Parkinson's disease and associated conditions comprising administering a carbidopa prodrug and an L-dopa prodrug to a subject with Parkinson's disease. 130-. (canceled)32. A method of treating Parkinson's disease comprising administering to a subject in need thereof a therapeutically effective amount of the pharmaceutical composition according to .33. The method of claim 32 , further comprising administering another anti-Parkinson's agent to the subject.34. A kit comprising the pharmaceutical composition of . The present disclosure relates to (a) carbidopa prodrugs, (b) L-dopa prodrugs, (c) pharmaceutical combinations and compositions comprising a carbidopa prodrug and/or an L-dopa prodrug, and (d) methods of treating Parkinson's disease and associated conditions comprising administering a carbidopa prodrug and an L-dopa prodrug to a subject with Parkinson's disease.Parkinson's disease is a chronic and progressive neurodegenerative condition characterized by reduced levels in the brain of the neurotransmitter dopamine (i.e., 3,4-dihydroxyphenethylamine). Administration of L-dopa (i.e., L-3,4-dihydroxyphenylalanine) currently is the most effective therapy for treating a patient with Parkinson's disease. L-dopa, which unlike dopamine can cross the blood-brain barrier, is enzymatically converted in the brain to dopamine resulting in an increase in dopamine levels:The conversion of L-dopa to dopamine is catalyzed by aromatic L-amino acid decarboxylase, a ubiquitous enzyme that promotes central as well as peripheral metabolism of L-dopa to dopamine. Due to the peripheral metabolism of L-dopa, a relatively large dose of L-dopa is required to achieve therapeutically effective dopamine levels in the brain. Administration of such large L-dopa doses results in elevated peripheral ...

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Номер записи: 33
30-03-2017 дата публикации

NOVEL COMPOUND, AND FLAVOR COMPOSITION AND/OR FRAGRANCE COMPOSITION CONTAINING SAME

Номер: US20170088503A1
Автор: ADACHI Kenichiro, Matsuda Hiroyuki
Принадлежит: TAKASAGO INTERNATIONAL CORPORATION

The present invention addresses the problem of providing a novel compound capable of imparting a highly appealing floral and verdant scent, and a flavor composition and/or fragrance composition containing the same. This compound is a racemic or optically active compound represented by general formula (1). 2. A flavor composition and/or fragrance composition comprising the racemic or optically active compound represented by the general formula (1) according to .3. A product imparted with a scent claim 2 , wherein the flavor composition and/or fragrance composition according to is combined with at least one product selected from the group consisting of beverages claim 2 , foods claim 2 , flagrances or cosmetics claim 2 , toiletry products claim 2 , air care products claim 2 , daily necessities and household goods claim 2 , compositions for oral use claim 2 , hair care products claim 2 , skin care products claim 2 , body care products claim 2 , detergents for clothing claim 2 , soft finishing agents for clothing claim 2 , quasi drugs claim 2 , and drugs.4. A method for improving a scent of a flavor and/or fragrance claim 1 , comprising adding the racemic or optically active compound represented by the general formula (1) according to . The present invention relates to a novel compound having a 3,5,5-trimethylheptane structure, a flavor composition and/or fragrance composition containing the compound, a fragrance or cosmetic, toiletry product, bathing agent, beverage, food, quasi drug, or drug containing the flavor composition and/or fragrance composition, and a method for strengthening a scent of a flavor and/or fragrance.In recent years, with the diversification of various food ingredients, food additives, beverages, foods (including favorite foods), fragrances or cosmetics, sanitation materials, sundries, drugs, and the like, formerly unknown new demands have been increasing for a flavor and/or fragrance used therein, and development of flavor substance and/or ...

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Номер записи: 34
19-06-2014 дата публикации

Isoprene oligomer, polyisoprene, processes for producing these materials, rubber composition, and pneumatic tire

Номер: US20140171675A1
Автор: Naoya Ichikawa, Norimasa Ohya, Yukino Miyagi
Принадлежит: Sumitomo Rubber Industries Ltd, Yamagata University NUC

The invention relates to an isoprene oligomer that contains a trans structural moiety and a cis structural moiety, which can be represented by the following formula (1), wherein at least 1 atom or group in the trans structural moiety is replaced by another atom or group. The invention also relates to a polyisoprene, which is biosynthesized using the isoprene oligomer and isopentenyl diphosphate. Further, this invention provides a rubber composition comprising the isoprene oligomer and/or the polyisoprene, and a pneumatic tire, including tire components (e.g., treads and sidewalls) formed from the rubber composition. wherein n represents an integer from 1 to 10; m represents an integer from 1 to 30; and Y represents a hydroxy group, a formyl group, a carboxy group, an ester group, a carbonyl group, or a group represented by the following formula (2):

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Номер записи: 35
01-04-2021 дата публикации

METHOD FOR PRODUCING RECYCLED MATERIAL, AND TIRE AND METHOD FOR PRODUCING TIRE

Номер: US20210095210A1
Автор: Iwasa Koichiro
Принадлежит:

There is provided a method for producing a recycled material, whereby a recycled material can be efficiently obtained from a tire. The method for producing a recycled material according to the present invention includes a step of subjecting a tire to a gasification treatment to generate a gas containing a C1 gas from the tire, and a step of obtaining a recycled material containing at least one species selected from the group consisting of isoprene, butadiene, a butanediol compound, a butanol compound, a butenal compound, succinic acid, and polymers of these compounds by using the gas containing the C1 gas. 111-. (canceled)12. A method for producing a tire , the method comprising: a step of subjecting a tire to a gasification treatment to generate a gas comprising a C1 gas from the tire , a step of obtaining a recycled tire material comprising at least one species selected from the group consisting of isoprene , butadiene , and polymers of these compounds by using the gas comprising the C1 gas , and a step of obtaining a tire by using the recycled tire material.13. The method for producing a tire according to claim 12 , wherein the tire to be used for the gasification treatment is a waste tire.14. The method for producing a tire according to claim 12 , wherein the gas comprising the C1 gas comprises COgas and hydrogen gas and x in the COgas is 1≤x≤2.151. The method for producing a tire according to claim 13 , wherein the gas comprising the C gas comprises COgas and hydrogen gas and x in the COgas is 1≤x≤2.16. The method for producing a tire according to claim 12 , wherein the step of obtaining a recycled tire material is a step of synthesizing isoprene by growing a microbial catalyst prepared by introducing a nucleic acid capable of coding isoprene synthase into a Clostridium microorganism in the presence of the resulting gas containing the C1 gas and hydrogen gas to obtain a recycled tire material comprising at least one species selected from the group consisting of ...

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Номер записи: 36
01-04-2021 дата публикации

Aldehydic Odorant

Номер: US20210095225A1
Автор: BIRKBECK Anthony Alexander, Chapuis Christian, MORETTI Robert
Принадлежит:

Described herein is compound of formula (I) 2. The method according to claim 1 , wherein R represents a n-butyl group.3. The method according to claim 1 , wherein the compound of formula (I) is selected from the group consisting of 3-(4-n-butyl-1-cyclohexen-1-yl)propanal and 3-[4-(1 claim 1 ,2-dimethylpropyl)-1-cyclohexen-1-yl]propanal.4. The method according to claim 1 , wherein the compound of formula (I) is 3-(4-n-butyl-1-cyclohexen-1-yl)propanal.5. A method to confer claim 1 , enhance claim 1 , improve or modify the odor properties of a perfuming composition or of a perfumed article claim 1 , the method comprising adding to the perfuming composition or the perfumed article an effective amount of at least a compound of formula (I) as defined in .6. A compound of formula (I) as defined in .7. A perfuming composition comprising:{'claim-ref': {'@idref': 'CLM-00006', 'claim 6'}, 'i) at least one compound of formula (I), as defined in ;'}ii) at least one ingredient selected from the group consisting of a perfumery carrier and a perfumery base; andiii) optionally at least one perfumery adjuvant.8. A perfumed consumer product comprising at least one compound of formula (I) claim 6 , as defined in .9. The perfumed consumer product according to claim 8 , wherein the perfumed consumer product is a perfume claim 8 , a fabric care product claim 8 , a body-care product claim 8 , a cosmetic preparation claim 8 , a skin-care product claim 8 , an air care product claim 8 , or a home care product.10. The perfumed consumer product according to claim 9 , wherein the perfumery consumer product is a fine perfume claim 9 , a splash or eau de perfume claim 9 , a cologne claim 9 , a shave or after-shave lotion claim 9 , a liquid or solid detergent claim 9 , a fabric softener claim 9 , a fabric refresher claim 9 , an ironing water claim 9 , a paper claim 9 , a bleach claim 9 , a carpet cleaner claim 9 , curtain-care products claim 9 , a shampoo claim 9 , a coloring preparation claim 9 , ...

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Номер записи: 37
12-05-2022 дата публикации

HYDROFORMYLATED TRIGLYCERIDES AND USES THEREOF

Номер: US20220144735A1
Автор: Hong Jian, Ionescu Mihail, Petrovic Zoran
Принадлежит:

This disclosure provides methods for the chemical modification of triglycerides that are highly enriched in specific fatty acids and subsequent use thereof for producing functionally versatile polymers. 122-. (canceled)23. A method of producing a triglyceride polyol composition , the method comprising:(a) hydroformylating a triglyceride oil having a fatty acid profile of at least 60% of C18:1 fatty acids to form a hydroformylated oil;(b) hydrogenating the hydroformylated oil of (a) to generate the triglyceride polyol composition having a fatty acid profile of at least 60% of C18 fatty acids that each have a primary hydroxyl group.24. The method of claim 23 , wherein the triglyceride oil has a fatty acid profile of at least 80% of C18:1 fatty acids.25. The method of claim 23 , wherein the triglyceride oil has a fatty acid profile of at least 90% of C18:1 fatty acids.26. The method of claim 23 , wherein the triglyceride oil has up to 9 triacylglycerol (TAG) species present in an amount of 1% or more.27. The method of claim 23 , wherein the triglyceride oil has up to 8 TAG species present in an amount of 1% or more.28. The method of claim 23 , wherein the triglyceride oil has up to 7 TAG species present in an amount of 1% or more.29. The method of claim 23 , wherein the triglyceride oil comprises 60% or more of triolein.30. A method of producing a polyurethane claim 23 , comprising:{'claim-ref': {'@idref': 'CLM-00023', 'claim 23'}, 'reacting the triglyceride polyol composition of with an isocyanate, thereby generating the polyurethane.'}31. A triglyceride polyol composition comprising:triacylglycerides having a fatty acid profile of at least 60% of C18 fatty acids that each have a primary hydroxyl group.32. The triglyceride polyol composition of claim 31 , wherein the triacylglycerides have a fatty acid profile of at least 80% of C18 fatty acids with a primary hydroxyl group.33. The triglyceride polyol composition of claim 31 , wherein the triacylglycerides have a ...

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Номер записи: 38
08-04-2021 дата публикации

CYCLOHEXENE PROPANAL DERIVATIVES AS PERFUMING INGREDIENTS

Номер: US20210101860A1
Автор: BIRKBECK Anthony Alexander, COULOMB Julien, QUINTAINE Julie
Принадлежит:

Described herein is a compound of formula (I) 3. A method to confer claim 1 , enhance claim 1 , improve or modify the odor properties of a perfuming composition or of a perfumed article claim 1 , which method comprises adding to said composition or article an effective amount of at least one compound of formula (I) as defined in .4. A method of using a compound of formula (I) as defined in claim 1 , said method comprising using the compound as a perfuming ingredient.5. A perfuming composition comprising;{'claim-ref': {'@idref': 'CLM-00001', 'claim 1'}, 'i) at least one compound of formula (I), as defined in ;'}ii) at least one ingredient selected from the group consisting of a perfumery carrier and a perfumery base; andiii) optionally at least one perfumery adjuvant.6. A perfumed consumer product comprising at least one compound of formula (I) claim 1 , as defined in .7. The perfumed consumer product according to claim 6 , wherein the product is a perfume claim 6 , a fabric care product claim 6 , a body-care product claim 6 , a cosmetic preparation claim 6 , a skin-care product claim 6 , an air care product claim 6 , or a home care product.8. The perfumed consumer product according to claim 6 , wherein the perfumery consumer product is a fine perfume claim 6 , a splash or eau de parfum claim 6 , a cologne claim 6 , a shave or after-shave lotion claim 6 , a liquid or solid detergent claim 6 , a fabric softener claim 6 , a fabric refresher claim 6 , an ironing water claim 6 , a paper claim 6 , a bleach claim 6 , a carpet cleaner claim 6 , a curtain-care product claim 6 , a shampoo claim 6 , a coloring preparation claim 6 , a color care product claim 6 , a hair shaping product claim 6 , a dental care product claim 6 , a disinfectant claim 6 , an intimate care product claim 6 , a hair spray claim 6 , a vanishing cream claim 6 , a deodorant or antiperspirant claim 6 , a hair remover claim 6 , a tanning or sun product claim 6 , a nail product claim 6 , a skin cleansing ...

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Номер записи: 39
21-04-2016 дата публикации

3-(4-ISOBUTYL-2-METHYLPHENYL) PROPANAL AS PERFUME INGREDIENT

Номер: US20160108342A1
Автор: Goeke Andreas, Kraft Philip, LAUE Heike, VOIROL Francis, ZOU Yue
Принадлежит:

A compound according to the formula (I) 2. A method comprising utilizing the compound according to formula (I) as a perfume ingredient in a composition comprising adding to said composition the compound according to formula (I).3. The method according to claim 2 , wherein the perfume ingredient has muguet odour characteristics.4. A perfume composition comprising the compound according to the formula (I).5. The perfume composition according to that is free of aryl-substituted alkanal odourants that are unsubstituted on the aryl ring at a position ortho to the substituent bearing the aldehyde functionality.6. The perfume composition according to comprising one or more additional fragrance ingredients.7. The perfume composition according to claim 4 , which exhibits muguet odour characteristics.8. A personal care or household care composition comprising a compound of formula (I) according to .9. A method of producing a muguet odour characteristic to a perfume composition comprising the step of adding to said composition the compound as defined in .10. A personal care or household care composition comprising a perfume composition as defined in .11. A personal care or household care composition comprising a perfume composition as defined in .12. A personal care or household care composition comprising a perfume composition as defined in .13. The perfume composition according to that is free of aryl-substituted propanals that are unsubstituted on the aryl ring at a position ortho to the substituent bearing the aldehyde functionality.14. The perfume composition according to that is free of 3-(4-tert-butylphenyl)-2-methylpropanal.15. The perfume composition according to comprising one or more additional fragrance ingredients. This invention relates to a perfume ingredient and perfume preparations containing same. In particular, the invention relates to said perfume ingredient or perfume preparations that exhibit muguet (lily of the valley) odour characteristics. Still more ...

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Номер записи: 40
23-04-2015 дата публикации

AROMATIC ALDEHYDE, AND EPOXY RESIN CURING AGENT AND EPOXY RESIN COMPOSITION COMPRISING THE AROMATIC ALDEHYDE

Номер: US20150111991A1
Автор: ASAI Yuiga, Kitamura Mitsuharu, Kuwahara Hisayuki, MATSUURA Yutaka, Wada Tomotaka
Принадлежит: MITSUBISHI GAS CHEMICAL COMPANY, INC.

There are provided a novel aromatic aldehyde compound capable of providing an epoxy resin coating film and an epoxy resin cured material satisfying all of the excellent surface property (smoothness, gloss), drying property, water resistance, transparency and adhesion, and an epoxy resin curing agent and an epoxy resin composition containing the aromatic aldehyde compound. The aromatic aldehyde has a branched alkyl group having 10 to 14 carbon atoms. 1. An aromatic aldehyde comprising a branched alkyl group , wherein the branched alkyl group has 10 to 14 carbon atoms.3. The aromatic aldehyde according to claim 1 , wherein the aromatic aldehyde is at least one selected from the group consisting of 4-(dodecan-6-yl)benzaldehyde and 4-(dodecan-5-yl)benzaldehyde.4. An epoxy resin curing agent claim 1 , comprising (A) a polyamine compound and (B) the aromatic aldehyde according to .5. The epoxy resin curing agent according to claim 4 , wherein (A) the polyamine compound is at least one selected from the group consisting of a polyamine represented by the following general formula (A1) claim 4 , a linear aliphatic polyamine represented by the following general formula (A2) claim 4 , and a compound obtained by adding a polyamine represented by the following general formula (A1) or (A2) to a compound comprising a glycidyl group in one molecule thereof:{'br': None, 'sub': 2', '2', '2', '2, 'HN—CH-A-CH—NH\u2003\u2003(A1)'} {'br': None, 'sub': 2', '2', '2', 'n', '2', '2', '2, 'HN—(CHCHNH)—CHCHNH\u2003\u2003(A2)'}, 'wherein A is a phenylene group or a cyclohexylene group; and'}wherein n is an integer of 0 to 4.6. An epoxy resin composition claim 4 , comprising the epoxy resin curing agent according to .7. The epoxy resin composition according to claim 6 , employed for coating or for civil engineering and construction.8. A cured epoxy resin coating film claim 6 , manufactured by curing the epoxy resin composition according to .9. A cured epoxy resin claim 6 , manufactured by curing ...

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Номер записи: 41
19-04-2018 дата публикации

A METHOD FOR PREPARING OPTICALLY ACTIVE CARBONYL COMPOUND

Номер: US20180105477A1
Автор: Chen Zhirong, Feng Ming, LI Haoran, SHAO Weikang, SHI Xingxing, Su Weiwei, YU GUANGXIONG, Yu Ming, YUAN Jintao, Zhang Yin, Zhang Yuhong, Zhao Lei, ZHOU YOUGUI, ZHU XIANDONG
Принадлежит:

The present invention discloses a method for preparing optically active carbonyl compound, comprising the following steps: under the catalysis of chiral amine salt and transition metal catalysts, with hydrogen and catalytic amount of dihydropyridine compound as hydrogen source, use α, β-unsaturated aldehydes or α, β-unsaturated troponoid compounds to conduct asymmetric catalytic reaction to obtain the optically active carbonyl compound. This method comes in moderate reaction condition, simple operation, and catalytic amount of dihydropyridine compounds usage, the target product is easy to be separated and purified from the reaction system, and the metal catalyst can be recycled, it is economical. 2. The method for preparing an optically active carbonyl compound according to claim 1 , which is characterized in that: in the R claim 1 , Rand R claim 1 , alkyl is alkyl containing 1 to 30 carbon atoms;heteroaryl is aromatic heterocyclic aryls containing 3 to 9 carbon atoms;alkoxy is cyclo-alkoxy or linear or branched alkoxys containing 1 to 30 carbon atoms, and these alkoxys can be substituted by fluorine, chlorine, bromine, iodine, hydroxy or aryl;acylaminos are acylaminos containing 1 to 20 carbon atoms.3. The method for preparing an optically active carbonyl compound according to claim 2 , which is characterized in that: the heteroaryl is: 2-furyl claim 2 , 2-pyrryl claim 2 , 2-thienyl claim 2 , 2-pyridyl claim 2 , 2-indolyl claim 2 , 3-furyl claim 2 , 3-pyrryl claim 2 , 3-thienyl claim 2 , 3-pyridyl claim 2 , or 3-indolyl;the alkoxies are: methoxyl, ethyoxyl, n-propoxyethyl, isopropoxy, n-butoxy, isobutoxy, 2-butoxy, tert-butoxy, n-pentyloxy, 2-pentyloxy, 2-pentyloxy, tert-pentyloxy, n-hexyloxy, cyclopropoxy, cyclobutoxy, cyclopentyloxy, cyclohexyloxy, heptyloxy, octyloxy, nonyloxy, decyloxy, undecyloxy, dodecyloxy, tridecyloxy, tetradecyloxy, pentadecyloxy, hexadecyloxy, heptadecyloxy, octadecyloxy, nonadecyloxy, eicosyloxy, phenylmethoxy, 1-phenylethoxy, or 2- ...

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Номер записи: 42
03-07-2014 дата публикации

Process for the preparation of beta-santalol

Номер: US20140187811A1
Автор: Anthony A. Birkbeck
Принадлежит: FIRMENICH SA

The present invention concerns a process for the preparation of a compound of formula (I) in the form of any one of its stereoisomers or mixtures thereof, wherein R represents a C 2 -C 10 group of formula COR a wherein R a is an alkyl or alkenyl group optionally comprising one or two ether functional groups or is a phenyl or benzyl group optionally substituted by one to three alkyl, alkoxyl, carboxyl, acyl, amino or nitro groups or halogen atoms.

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Номер записи: 43
29-04-2021 дата публикации

Dienal compound and flavor composition

Номер: US20210122693A1
Автор: Akihiro KAWARAYA, Kyoko Zaizen, Teruhiko Inaba, Tomoya Takahashi
Принадлежит: Takasago International Corp

The present invention relates to: a novel dienal compound which has an aromatic odor useful for use as a compound flavor raw material or the like; and a flavor composition containing the dienal compound. The dienal compound according to the present invention is characterized by being represented by general formula (1): (wherein R represents an alkyl group having 8 to 10 carbon atoms; and a wavy line represents a cis form, a trans form, or a mixture of a cis form and a trans form).

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Номер записи: 44
27-05-2021 дата публикации

METHOD FOR PRODUCING AT LEAST ONE OF UNSATURATED ALDEHYDE AND UNSATURATED CARBOXYLIC ACID AND CATALYST FOR PRODUCING AT LEAST ONE OF UNSATURATED ALDEHYDE AND UNSATURATED CARBOXYLIC ACID

Номер: US20210155569A1
Автор: Hiraoka Ryota, Kawamura Tomoyuki, Nakano Takanori, YASUDA Shogo
Принадлежит: Nippon Kayaku Kabushiki Kaisha

Provided is a method for producing at least one of an unsaturated aldehyde and an unsaturated carboxylic acid from an alkene by an oxidation reaction, in which a n-layered catalyst layer (n≥2) is provided in a gas flow direction in a reaction tube, two or more kinds of catalysts having different activities are used; and the catalysts are packed in such a manner that dT≤20° C. is satisfied, when a difference between a temperature PTof an exothermic peak in a n-th layer as counted from a gas inlet and a minimum value mTof a temperature of a catalyst layer which appears between an exothermic peak in a (n−1)th layer and an exothermic peak in a n-th layer from the gas inlet is represented as dT (=PT−mT), and the change rate of dT is 2.5 or less at a reaction bath temperature within a range of ±6° C. of a reaction bath temperature at which the highest yield is obtained. 1. A method for producing at least one of an unsaturated aldehyde and an unsaturated carboxylic acid from an alkene by an oxidation reaction ,wherein a n-layered catalyst layer (n≥2) is provided in a gas flow direction in a reaction tube,two or more kinds of catalysts having different activities are used; and{'sub': n', 'n-1', 'n', 'n-1, 'the catalysts are packed in such a manner that dT≤20° C. is satisfied, when a difference between a temperature PTof an exothermic peak in a n-th layer as counted from a gas inlet and a minimum value mTof a temperature of a catalyst layer which appears between an exothermic peak in a (n−1)th layer and an exothermic peak in a n-th layer from the gas inlet is represented as dT (=PT−mT), and'}the change rate of dT is 2.5 or less at a reaction bath temperature within a range of ±6° C. of a reaction bath temperature at which the highest yield is obtained.2. The method for producing at least one of an unsaturated aldehyde and an unsaturated carboxylic acid according to claim 1 ,wherein at the reaction bath temperature within a range of ±6° C. of the reaction bath temperature at ...

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Номер записи: 45
01-09-2022 дата публикации

Modular Chemical Probe For Detection Of Amino Acid Citrulline In Physiological Samples

Номер: US20220276257A1
Автор: Grant Jennifer E., Kadnikov Dmitry V.
Принадлежит:

An improved chemical probe for the detection of the amino acid citrulline combines: 1) a reactive head formed of 1,3-dicarbonyl moiety that reacts with a citrulline side chain in an improved manner compared to currently used 1,2-dicarbonyl moieties; and 2) a modular action of the probe where citrulline side chains are labeled first using reactive heads described above, and attachment of a read-out subunit or tag, be it a fluorophore, a nanoparticle, or an antigen is performed separately. The modular nature of the chemical probe increases the sensitivity of the probes due to their smaller size. Additionally, the chemical probes of the present disclosure allow the same sample to be analyzed using a variety of read-out methods. 1. A chemical probe for the detection of the amino acid citrulline comprising a reactive head , wherein the reactive head is formed of 1 ,3-dicarbonyl moiety.3. The probe of wherein the reactive head includes a triple bond opposite the 1 claim 1 ,3-dicarbonyl moeity.4. The probe of wherein the 1 claim 3 ,3-dicarbonyl moiety includes a ketone-ketone claim 3 , a ketone-aldehyde claim 3 , or an aldehyde-aldehyde structure.11. The probe of further comprising a detection tag bonded to reactive head.12. The probe of wherein the detection tag comprises:a. a probe linker attached to the reactive head; andb. a read-out tag attached to the probe linker.13. The probe of wherein the probe tinker is an azide-modified probe linker.14. The probe of wherein the read-out tag is a fluorescent read-out tag.16. The probe of wherein the read-out tag is a biotinylated read-out tag.18. The probe of wherein the read-out tag is a superparamagnetic nanoparticle read-out tag.20. A method for detecting the presence of the amino acid citrulline in proteins from biological samples claim 12 , the method comprising the steps of:{'claim-ref': {'@idref': 'CLM-00001', 'claim 1'}, 'a) providing the detection probe of ;'}b) reacting the reactive head of the probe with citrulline to ...

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Номер записи: 46
17-05-2018 дата публикации

MIXED METAL OXIDE AMMOXIDATION CATALYSTS

Номер: US20180133699A1
Автор: Brazdil James F., Toft Mark A.
Принадлежит: INEOS EUROPE AG

A catalytic composition useful for the conversion of an olefin selected from the group consisting of propylene, isobutylene or mixtures thereof, to acrylonitrile, methacrylonitrile, and mixtures thereof. The catalytic composition comprises a complex of metal oxides comprising rubidium, bismuth, cerium, molybdenum, iron and other promoters, with a desirable composition. 1. A catalytic composition comprising a complex of metal oxides wherein the relative ratios of the listed elements in said catalyst are represented by the following formula:{'br': None, 'sub': m', 'a', 'b', 'c', 'd', 'e', 'f', 'g', 'h', 'n', 'x, 'MoBiFeADEFGCeRbO'} D is at least one element selected from the group consisting of nickel, cobalt, manganese, zinc, magnesium, calcium, strontium, cadmium and barium;', 'E is at least one element selected from the group consisting of chromium, tungsten, boron, aluminum, gallium, indium, phosphorus, arsenic, antimony, vanadium and tellurium;', 'F is at least one element selected from the group consisting of lanthanum, praseodymium, neodymium, samarium, europium, gadolinium, terbium, dysprosium, holmium, erbium thulium, ytterbium, lutetium, scandium, yttrium, titanium, zirconium, hafnium, niobium, tantalum, aluminum, gallium, indium, thallium, silicon lead and germanium;', 'G is at least one element selected from the group consisting of silver, gold, ruthenium, rhodium, palladium, osmium, iridium, platinum and mercury; and, 'wherein A is at least one element selected from the group consisting of lithium, sodium, potassium, and cesium; and'} a is greater than 0, but less than or equal to 7,', 'b is 0.1 to 7,', 'c is greater than 0, but less than or equal to 5,', 'd is 0.1 to 12,', 'e is 0 to 5,', 'f is 0 to 5,', 'g is 0 to 0.2,', 'h is 0.01 to 5,', 'm is 10 to 15,', 'n is greater than 0, but less than or equal to 5,', 'x is the number of oxygen atoms required to satisfy the valence requirements of the other component elements present; and, 'a, b, c, d, e, f, g, ...

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Номер записи: 47
07-08-2014 дата публикации

TETRA-O-SUBSTITUTED BUTANE-BRIDGE MODIFIED NDGA DERIVATIVES, THEIR SYNTHESIS AND PHARMAECUTICAL USE

Номер: US20140221384A1
Автор: Chen Qingqi, Heller Jonathan Daniel, Lopez Rocio Alejandra, Morris Amanda Jean
Принадлежит: ERIMOS PHARMACEUTICALS LLC

The present invention relates to nordihydroguaiaretic acid derivative compounds, namely, butane bridge modified nordihydroguaiaretic acid (NDGA) compounds and butane bridge modified tetra-O-substituted NDGA compounds, pharmaceutical compositions containing them, methods of making them, and methods of using them and kits including them for the treatment of diseases and disorders, in particular, diseases resulting from or associated with a virus infection, such as HIV infection, HPV infection, or HSV infection, an inflammatory disease, such as various types of arthritis and inflammatory bowel diseases, metabolic diseases, such as diabetes and hypertension, or a proliferative disease, such as diverse types of cancers. 2. A composition comprising the BB-N compound of and a pharmaceutically acceptable carrier claim 1 , optionally with other pharmaceutically acceptable excipients.3. A method of administering to a subject an amount of the BB-N compound of alone or as part of a pharmaceutical composition effective prophylactically or for treating a viral infection.4. A method of administering to a subject an amount of the BB-N compound of alone or as part of a pharmaceutical composition effective prophylactically or for treating a proliferative disease.5. A method of administering to a subject an amount of the BB-N compound of alone or as part of a pharmaceutical composition effective prophylactically or for treating an inflammatory disease.6. A method of administering to a subject an amount of the BB-N compound of alone or as part of a pharmaceutical composition effective prophylactically or for treating a metabolic disease.7. A method of administering to a subject an amount of the BB-N compound of alone or as part of a pharmaceutical composition effective prophylactically or for treating a vascular disease.8. A kit comprising a pharmaceutical composition comprising the BB-N compound of and instructions for its use prophylactically or for treating at least one of a viral ...

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Номер записи: 48
02-06-2016 дата публикации

BI-CYCLO ALDEHYDE AS PERFUMING INGREDIENT

Номер: US20160152921A1
Автор: MORETTI Robert
Принадлежит: FIRMENICH SA

The present invention relates to the field of perfumery and provides certain bi-cyclo derivatives of formula (I) 3. A compound according to claim 1 , wherein Rrepresents a hydrogen atom or a methyl or ethyl group.4. A compound according to claim 1 , wherein A represents a Calkanediyl group of formula CHCHCHCH claim 1 , or CRCRCHwherein each R claim 1 , independently from each other is a hydrogen atom or a methyl group.5. A compound according to claim 4 , wherein A represents a group of formula CHCHCHor CHCHC(CH).6. A compound according to claim 1 , characterized in that it is in the form of mixture consisting of isomers E and Z and wherein said isomers E represent at least 50% of the total mixture.7. A compound according to claim 1 , which is 5-(2 claim 1 ,3-dihydro-1H-inden-5-yl)-4-methylpent-4-enal.8. (canceled)9. A perfuming composition comprising{'claim-ref': {'@idref': 'CLM-00001', 'claim 1'}, 'i) at least one compound of formula (I), as defined in ;'}ii) at least one ingredient selected from the group consisting of a perfumery carrier and a perfumery base; andiii) optionally at least one perfumery adjuvant.10. A perfuming consumer product comprising at least one compound of formula (I) claim 1 , as defined in .11. A perfuming consumer product according to claim 10 , characterized in that the perfumery consumer product is a perfume claim 10 , a fabric care product claim 10 , a body-care product claim 10 , an air care product or a home care product.12. A perfuming consumer product according to claim 10 , wherein the perfumery consumer product is a fine perfume claim 10 , a cologne claim 10 , an after-shave lotion claim 10 , a liquid or solid detergent claim 10 , a fabric softener claim 10 , a fabric refresher claim 10 , an ironing water claim 10 , a paper claim 10 , a bleach claim 10 , a shampoo claim 10 , a coloring preparation claim 10 , a hair spray claim 10 , a vanishing cream claim 10 , a deodorant or antiperspirant claim 10 , a perfumed soap claim 10 , ...

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Номер записи: 49
07-05-2020 дата публикации

Process for preparing methacrolein

Номер: US20200140363A1
Автор: Dmitry A. KRAPCHETOV, Jinsuo Xu, Mark A. SILVANO, Reetam Chakrabarti
Принадлежит: Rohm and Haas Co

Provided is a process for preparing methacrolein which maximizes capture of methanol. Also provided are processes for producing methacrylic acid and methyl methacrylate.

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Номер записи: 50
21-05-2020 дата публикации

PROCESS FOR PREPARING METHACROLEIN

Номер: US20200157032A1
Автор: Chakrabarti Reetam, Krapchetov Dmitry A., Silvano Mark A., Xu Jinsuo
Принадлежит:

Provided is a process for preparing methacrolein which maximizes capture of methanol. Also provided are processes for producing methacrylic acid and methyl methacrylate. 1. A process for preparing methacrolein comprising:(a) mixing water and an amine-acid catalyst to provide a catalyst stream;(b) sending the catalyst stream and a reaction stream comprising propionaldehyde, formaldehyde, and methanol to a reactor to produce a first intermediate stream comprising methacrolein, methanol, and at least 8 weight % water;(c) providing the first intermediate stream to a first phase separator to produce (i) a first aqueous phase comprising methacrolein, methanol, amine-acid catalyst, and at least 65 weight % water, and (ii) a first organic phase comprising water, at least 85 weight % methacrolein, and less than 5 weight % methanol;(d) distilling the first aqueous phase in a first distillation column to produce (i) a second intermediate stream comprising methacrolein, water, and less than 75 weight % methanol, (ii) a bottoms stream comprising amine-acid catalyst, and (iii) a side draw stream comprising methanol and water;(e) distilling the first organic phase and the second intermediate stream in a second distillation column to produce (i) a third intermediate stream comprising methacrolein and less than 2 weight % methanol, and (ii) an overhead stream;(f) distilling the third intermediate stream in a third distillation column to produce (i) a product stream comprising methacrolein and water greater than 97 weight %, less than 2 weight % methanol, and less than 1 weight % of impurities comprising one or more of acetic acid, propionic acid, methacrolein dimer, and 2-methyl-2-pentenal, and (ii) a waste stream;(g) recycling at least part of the overhead stream to the first phase separator; and(h) recycling at least part of the bottoms stream to the catalyst stream.2. The process of claim 1 , wherein the propionaldehyde is produced by contacting ethylene with CO and Hin the ...

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Номер записи: 51
21-06-2018 дата публикации

NOVEL AROMA CHEMICALS HAVING A 1,2,2-TRIMETHYLCYCLOPENTAN-1-YL MOIETY

Номер: US20180171262A1
Автор: ARDEKAR Sadanand, HINDALEKAR Shrirang, PELZER Ralf, Rüdenauer Stefan, Swaminathan Vijay Narayanan
Принадлежит:

The present invention relates to novel compounds of general formulae (la), (lb) and (Ic) and to the stereoisomers thereof. The compounds are useful as a fragrance or as flavor as they have a sandalwood like scent. The invention also relates to a method for imparting or modifying a scent or a flavor to a composition by including said compounds into such composition, to a fragrance containing composition and/or a fragrance material containing said compound and to a process for preparing these compounds. X is C(R)—OH or C═O; Ris selected from the group consisting of hydrogen, C-C-alkyl, C-C-alkenyl and C-C-cycloalkyl, Ris selected from the group consisting of hydrogen, C-C-alkyl, C-C-alkenyl and C-C-cycloalkyl, Ris C-C-alkyl, Ris selected from the group consisting of hydrogen and C-C-alkyl, Ris hydrogen or together with Ris CH; Ris selected from the group consisting of hydrogen and C-C-alkyl. 114.-. (canceled)16. The compound or mixture of claim 15 , wherein X is CO.17. The compound or mixture of claim 15 , wherein X is CH—OH.18. The compound or mixture of claim 15 , which is a compound of formula (Ia) claim 15 , a mixture of compounds of formula (Ia) or a mixture of at least one compound of formula (Ia) with one or more compounds of the formulae (Ic).19. The compound or mixture of claim 15 , which is a compound of formula (Ic) claim 15 , a mixture of compounds of formula (Ic) or a mixture of at least one compound of formula (Ic) with one or more compounds of the formulae (Ia).20. The compound of claim 15 , which is selected from the group consisting of4-(1,2,2-trimethylcyclopentyl)but-2-enal,2-methyl-4-(1,2,2-trimethylcyclopentyl)but-2-enal,2-ethyl-4-(1,2,2-trimethylcyclopentyl)but-2-enal,5-(1,2,2-trimethylcyclopentyl)pent-3-en-2-one,3-methyl-5-(1,2,2-trimethylcyclopentyl)pent-3-en-2-one,3-ethyl-5-(1,2,2-trimethylcyclopentyl)pent-3-en-2-one,6-(1,2,2-trimethylcyclopentyl)hex-4-en-3-one,4-methyl-6-(1,2,2-trimethylcyclopentyl)hex-4-en-3-one,4-(1,2,2-trimethylcyclopentyl) ...

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Номер записи: 52
28-06-2018 дата публикации

SELECTIVE AEROBIC OXIDATION OF DIMETHYLBIPHENYLS

Номер: US20180179138A1
Автор: ALLEN Joshua W., Dakka Jihad M., DeFLORIO Victor, LANCI Michael P., METZ Jarid M., Patel Bryan A., Salciccioli Michael, Weber Michael W., Zushma Stephen
Принадлежит:

A process for selective oxidation of dimethyl-1,1′-biphenyl to form methyl-1,1′-biphenyl mono-carboxylic acid(s), comprising contacting a solution of dimethyl-1,1′-biphenyl in acetic acid solvent in the presence of a Co(II) acetate catalyst and air, and optionally adding a co-solvent, or adding sodium or potassium acetate, and oxidizing the dimethyl-1,1′-biphenyl under time and temperature conditions sufficient to form one or more methyl-1,1′-biphenyl mono-carboxylic acid(s). The mono-carboxylic acids are advantageously isolated and esterified to form biphenyl mono-esters for use as plasticizers. 2. The process of claim 1 , wherein the selectivity for formation of methyl-1 claim 1 ,1′-biphenyl mono-carboxylic acids is enhanced relative to the formation of other 1 claim 1 ,1′-biphenyl oxygenates.3. The process of claim 1 , comprising adding the co-solvent claim 1 , wherein the co-solvent is one that affects the acid strength of the solution.4. The process of claim 3 , wherein the co-solvent is trifluorotoluene.5. The process of claim 1 , comprising adding sodium acetate or potassium acetate.6. The process of claim 1 , further comprising adding one or more of Mn(II) acetate claim 1 , Ni(II) acetate claim 1 , Zn(II) acetate claim 1 , Zr(IV) acetate claim 1 , Fe(II) acetate.7. The process of claim 1 , wherein the dimethyl-1 claim 1 ,1′-biphenyl is provided in a mixture of dimethylbiphenyl isomers.8. The process of claim 7 , further comprising limiting the total conversion to 55-70% when the 3 claim 7 ,3′-isomers of dimethylbiphenyl comprise less than 10 wt % in the feed claim 7 , so as to increase the overall yield of methyl-1 claim 7 ,1′-biphenyl mono-carboxylic acids relative to other 1 claim 7 ,1′-biphenyl oxygenates.9. The process of claim 7 , further comprising limiting the total conversion to 45-55% when the 3 claim 7 ,3′-isomers of dimethylbiphenyl comprise between 10 and 30 wt % in the feed claim 7 , so as to increase the overall yield of methyl-1 claim 7 ,1′- ...

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Номер записи: 53
28-06-2018 дата публикации

Storage of 3-methylthiopropionaldehyde and methyl mercaptan

Номер: US20180179155A1
Автор: Andrea Kopp, Christian Kaiser, Harald Jakob, Judith Hierold, Lucas GEIST, Sascha Ceylan, Stephan Rautenberg
Принадлежит: EVONIK DEGUSSA GmbH

A compound, which is 1-(1,3-bis(methylthio)propoxy)-3-(methylthio)propan-1-ol, a composition containing the compound, a method for the preparation thereof, a method for preparing 3-methylthiopropionaldehyde by reacting 1-(1,3-bis(methylthio)propoxy)-3-(methylthio)propan-1-ol with acrolein, and also to the use of 1-(1,3-bis(methylthio)propoxy)-3-(methylthio)propan-1-ol or compositions containing the compound for the storage and/or transport of 3-methylthiopropionaldehyde and/or methyl mercaptan.

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Номер записи: 54
29-06-2017 дата публикации

PROCESS FOR PRODUCING 2,6-DIMETHYL-5-HEPTEN-1-AL

Номер: US20170183280A1
Автор: PELZER Ralf, Schneider Daniel, TELES Joaquim H., Vautravers Nicolas
Принадлежит:

The present invention relates to a process for producing 2,6-dimethyl-5-hepten-1-al, which comprises reacting 3,7-dimethyl-1,6-octadiene (dihydromyrcene, beta-citronellene) with NO in a solvent or solvent mixture containing at least one solvent having a proton-donating functional group. 110.-. (canceled)11. A process for preparing 2 ,6-dimethyl-5-hepten-1-al , which comprises reacting 3 ,7-dimethyl-1 ,6-octadiene with NO in a solvent or solvent mixture containing at least one solvent having a proton-donating functional group.12. The process of claim 11 , wherein the solvent having a proton-donating functional group is an aliphatic alcohol.13. The process of claim 11 , wherein the solvent having a proton-donating functional group is a C-C-alkanol.14. The process of claim 11 , wherein the solvent having a proton-donating functional group is methanol.15. The process of claim 11 , wherein the amount of solvent having a proton-donating functional group is present in an amount of 6 to 40 mol per 1 mol of 3 claim 11 ,7-dimethyl-1 claim 11 ,6-octadiene.16. The process of claim 11 , wherein the concentration of 3 claim 11 ,7-dimethyl-1 claim 11 ,6-octadiene in the solvent or solvent mixture is from 10 to 40% by weight claim 11 , based on the total weight of solvent or solvent mixture and 3 claim 11 ,7-dimethyl-1 claim 11 ,6-octadiene.17. The process of claim 11 , wherein the reaction of 3 claim 11 ,7-dimethyl-1 claim 11 ,6-octadiene with NO is performed until the conversion of 3 claim 11 ,7-dimethyl-1 claim 11 ,6-octadiene is in the range of from 3 to 20%.18. The process of claim 11 , wherein the reaction is performed at a pressure in the range of 5 to 400 bar.19. The process of wherein the molar ratio of NO to 3 claim 11 ,7-dimethyl-1 claim 11 ,6-octadiene is in the range from1:20 to 4:1.20. The process of claim 11 , wherein the molar ratio of NO to 3 claim 11 ,7-dimethyl-1 claim 11 ,6-octadiene is in the range from 1:10 to 1:1.21. The process of claim 14 , wherein the ...

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Номер записи: 55
18-09-2014 дата публикации

(z,z,e)-1-chloro-6,10,12-pentadecatriene and method for preparing (z,z,e)-7,11,13-hexadecatrienal by using same

Номер: US20140275656A1
Автор: Miyoshi Yamashita, Naoki Ishibashi, Takehiko Fukumoto, Yuki Miyake
Принадлежит: Shin Etsu Chemical Co Ltd

Provided are (Z,Z,E)-1-chloro-6,10,12-pentadecatriene that can be synthesized without an oxidation reaction and a method for preparing (Z,Z,E)-7,11,13-hexadecatienal by using (Z,Z,E)-1-chloro-6,10,12-pentadecatriene while not using an oxidation reaction. More specifically, provided is a method for preparing (Z,Z,E)-7,11,13-hexadecatrienal including a step of reacting a Grignard reagent into which (Z,Z,E)-1-chloro-6,10,12-pentadecatriene is converted with ethyl orthoformate to obtain (Z,Z,E)-1,1-diethoxy-7,11,13-hexadecatriene, and a step of treating the (Z,Z,E)-1,1-diethoxy-7,11,13-hexadecatriene with an acid to obtain (Z,Z,E)-7,11,13-hexadecatrienal.

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Номер записи: 56
15-07-2021 дата публикации

CONTINUOUS PREPARATION OF AN OPTICALLY ACTIVE CARBONYL COMPOUND BY ASYMMETRIC HYDROGENATION

Номер: US20210214296A1
Автор: Bey Oliver, Zehner Peter
Принадлежит:

Process for the continuous production of an optically active carbonyl compound by asymmetric hydrogenation of a prochiral α,β-unsaturated carbonyl compound with hydrogen in the presence of a homogeneous rhodium catalyst that has at least one chiral ligand, wherein a liquid reaction mixture comprising the prochiral α,β-unsaturated carbonyl compound is subjected in a first, backmixed reactor to a gas/liquid two-phase hydrogenation, and the liquid reaction mixture is then further hydrogenated in a second reactor, wherein the prochiral α,β-unsaturated carbonyl compound is employed in the first reactor in a concentration from 3% to 20% by weight. The process allows a high total conversion to the prochiral α,β-unsaturated carbonyl compound. 1. A process for the continuous production of an optically active carbonyl compound by asymmetric hydrogenation of a prochiral α ,β-unsaturated carbonyl compound with hydrogen in the presence of a homogeneous rhodium catalyst that has at least one chiral ligand , whereina liquid reaction mixture comprising the prochiral α,β-unsaturated carbonyl compound is subjected in a first, backmixed reactor to a gas/liquid two-phase hydrogenation, andthe liquid reaction mixture is then further hydrogenated in a second reactor,wherein the prochiral α,β-unsaturated carbonyl compound is employed in the first reactor in a concentration from 3% to 20% by weight.2. The process according to claim 1 , wherein hydrogen gas undergoes dispersion in the liquid reaction mixture in a section of the second reactor located at the entrance to the second reactor.3. The process according to claim 1 , wherein the prochiral α claim 1 ,β-unsaturated carbonyl compound is employed in the first reactor in a concentration at which the reaction rate is at least 0.8 times V claim 1 , Vbeing the maximum value for the reaction rate in a plot of the reaction rate against the concentration of the prochiral α claim 1 ,β-unsaturated carbonyl compound.4. The process according to ...

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Номер записи: 57
05-07-2018 дата публикации

METHOD FOR PRODUCING UNSATURATED ALDEHYDE AND/OR UNSATURATED CARBOXYLIC ACID

Номер: US20180186712A1
Автор: Hiraoka Ryota, Kawamura Tomoyuki, Sugiyama Motohiko, YASUDA Shogo
Принадлежит: Nippon Kayaku Kabushiki Kaisha

Provided is a method for producing an unsaturated aldehyde and/or an unsaturated carboxylic acid, which enables one to achieve an operation stably over a long period of time while improving an effective yield, even in a high-load reaction, and in the method for producing an unsaturated aldehyde and/or an unsaturated carboxylic acid, multilayer filling of stacking two or more catalyst layers each containing a complex metal oxide catalyst in the axial direction of the tube under specified conditions is performed, and the catalyst layer on the most gas outlet side in the tube axis contains a catalyst containing a compound represented by a specified formulation formula. 2. The method for producing an unsaturated aldehyde and/or an unsaturated carboxylic acid according to claim 1 ,wherein in a step of preparing the compound represented by the formula (1), a molybdenum component raw material is constituted of only an ammonium molybdate, and a weight of water for dissolution is 8.5 times or less relative to a weight of molybdenum contained in the ammonium molybdate; anda bismuth component raw material is constituted of only bismuth nitrate, a weight of a nitric acid aqueous solution for dissolution is 2.3 times or more relative to a weight of bismuth contained in the bismuth nitrate, and a concentration of nitric acid of the nitric acid aqueous solution for dissolving bismuth nitrate therein is 10% by weight or more.3. The method for producing an unsaturated aldehyde and/or an unsaturated carboxylic acid according to claim 1 ,wherein the complex metal oxide catalyst is a spherical coating catalyst in which catalytic active components are supported on a surface of an inert carrier.4. The method for producing an unsaturated aldehyde and/or an unsaturated carboxylic acid according to claim 1 ,wherein a load of the alkene in the raw material gas to be supplied into the multitubular reactor is 100 times or more (converted in a standard state) relative to a unit catalyst volume ...

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Номер записи: 58
11-06-2020 дата публикации

PROCESS FOR PREPARING METHACROLEIN

Номер: US20200181053A1
Автор: Chakrabarti Reetam, Como Charles, Hruby Sarah L., Krapchetov Dmitry A., Ngo Minh N., Sathiosatham Muhunthan, Silvano Mark A.
Принадлежит:

Provided is a process for preparing dry methacrolein which maximizes capture of methanol. Also provided is a process for producing methyl methacrylate. 1. A process for preparing methacrolein comprising:(a) mixing water and an amine-acid catalyst to provide a catalyst stream;(b) sending the catalyst stream and a reaction stream comprising propionaldehyde, formaldehyde, and methanol to a reactor to produce a first intermediate stream comprising methacrolein, methanol, and at least 8 weight % water;(c) providing the first intermediate stream to a phase separator to produce (i) an organic phase comprising (A) less than 4 weight % water, and (B) at least 70 weight % methacrolein, and (ii) an aqueous phase comprising methacrolein, methanol, amine-acid catalyst, and at least 70 weight % water, wherein the phase separator is operated at a temperature of less than 25° C.;(d) distilling the organic phase in a first distillation column to produce (i) a first product stream comprising (A) methacrolein and methanol in a combined amount of at least 95 weight %, (B) less than 4 weight % water, and (C) less than 1 weight % of impurities comprising one or more of acetic acid, propionic acid, methacrolein dimer, and 2-methyl-2-pentenal, and (ii) a first waste stream;(e) distilling the aqueous phase in a second distillation column to produce (i) a second product stream comprising methacrolein, methanol, and less than 5 weight % water, (ii) a bottoms stream comprising amine-acid catalyst, and (iii) a side draw stream comprising water and less than 2 weight % methanol; and(h) recycling at least part of the bottoms stream to the catalyst stream.2. The process of claim 1 , wherein the propionaldehyde is produced by contacting ethylene with CO and Hin the presence of a hydroformylation catalyst.3. The process of claim 1 , further comprising providing at least part of the first product stream to a process comprising contacting the methacrolein with methanol and an oxygen-containing gas in ...

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Номер записи: 59
11-06-2020 дата публикации

7-methyl-3-methylene-7-octenal acetal compund and methods for producing aldehyde compound and ester compound using the same

Номер: US20200181059A1
Автор: Akihiro Baba, Takeshi Kinsho, SR., Tomohiro Watanabe, Yusuke Nagae
Принадлежит: Shin Etsu Chemical Co Ltd

There are provided methods of efficiently producing compounds that are, for example, sex pheromones of San Jose Scale. For example, there is provided a method for producing a 7-methyl-3-methylene-7-octenyl carboxylate compound (4), the method including the steps of: hydrolyzing a 7-methyl-3-methylene-7-octenal acetal compound (1) to obtain 7-methyl-3-methylene-7-octenal (2); reducing the 7-methyl-3-methylene-7-octenal (2) to obtain 7-methyl-3-methylene-7-octenol (3); and esterifying the 7-methyl-3-methylene-7-octenol (3) to obtain a 7-methyl-3-methylene-7-octenyl carboxylate compound (4).

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Номер записи: 60
23-07-2015 дата публикации

COMPOUNDS FROM ANTRODIA CAMPHORATE AND THEIR USE IN TREATMENT OF DIABETES MELLITUS

Номер: US20150203430A1
Автор: Chen Chin-piao, Hsu Chia-Yu, Shivaji Sulake Rohidas, WENG CHING-FENG
Принадлежит: National Dong Hwa University

The present invention relates to a method or composition for treating diabetes mellitus, comprising administering a subject with a pharmaceutical composition comprising a therapeutically effective amount of an active compound from , such as antroquinonols, and a pharmaceutically acceptable carrier. In addition, the prevent invention provides a new process for the total synthesis of antroquinonol. Also provided are the new compounds produced during the process for preparing of antroquinonol. 2. (canceled)3. The method of claim 1 , wherein the compound having the general formula (I) is antroquinonol.4. The method of claim 1 , wherein the compound having the general formula (I) is (+)-antroquinonol.5. The method of claim 1 , wherein the compound having the general formula (I) is (−)-antroquinonol.6. (canceled)7. The method of claim 1 , wherein the diabetes mellitus is type 2 diabetes mellitus.8. The method of claim 1 , wherein the subject is a patient suffered from diabetes mellitus with insulin resistance.9. The method of claim 1 , wherein the compound having the general formula (I) is effective for improving glucose uptake.10. The method of claim 1 , wherein the compound having the general formula (I) provides an effect on the glycemic control.11. The method of claim 1 , wherein antroquinonol is effective for inhibiting Dipeptidyl peptidase-4 (DPP4) activity and enhancing AMP-activated protein kinase (AMPK) activation.12. The method of claim 1 , wherein antroquinonol provides synergistic effects in combination of and insulin.13. A process for preparation of antroquinonol comprising the steps of asymmetric addition of diethyl zinc claim 1 , Claisen rearrangement claim 1 , ring-closing metathesis claim 1 , and lactonization.15. (canceled)17. A pharmaceutical composition for treating diabetes mellitus comprising the compound of .18. A pharmaceutical composition for treating diabetes mellitus comprising insulin or an insulin analogue in combination of the compound of ...

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Номер записи: 61
18-06-2020 дата публикации

Pheromone clathrates

Номер: US20200187503A1
Автор: Jallal Gnaim
Принадлежит: Agrorim Ltd

A slow-release composition comprising: first host material comprising a mesoporous molecular sieve; guest material within the first host material, the guest material comprising at least one pheromone, wherein the pheromone is selected from a group consisting of: 1,7-dioxaspiro-5,5-undecane; Z-7-Tetradecenal; E-11-hexadecenal; E-11-Hexedecenyl-1-acetate; E,E-8,11-dodecandien-1-ol; Z,E-9,11,13-Tetradecatrienal, and E,Z,Z-3,8,11-Tetradecatrienyl acetate, and mixtures thereof.

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Номер записи: 62
29-07-2021 дата публикации

CYCLOPROPYL RING OPENING BY ALPHA ALKYLATION OF AN ALDEHYDE WITH A POLYCYCLIC OLEFIN

Номер: US20210230089A1
Автор: QUINTAINE Julie
Принадлежит:

Described herein is a process including alpha alkylation of an aldehyde with a polycyclic olefin followed by a ring opening step in order to provide a compound of formula 2. The process according to claim 1 , wherein the aldehyde is propanal.4. The process according to claim 1 , wherein the photoredox catalyst is an organic photocatalyst claim 1 , an iridium complex claim 1 , or a ruthenium complex.6. The process according to claim 1 , wherein the compound of formula (I) is selected from the group consisting of 2-methyl-3-(2 claim 1 ,3 claim 1 ,4 claim 1 ,4-tetramethylcyclohex-1-en-1-yl)prop anal claim 1 , 2-methyl-3-(3-methyl-2-pentylcyclopent-1-en-1-yl)propanal claim 1 , 3-(3-isopropyl-3-methylcyclopent-1-en-1-yl)-2-methylpropanal claim 1 , and 3 -((R)-3-isopropyl-3-methylcyclopent-1-en-1-yl)-2-methylpropanal.8. A method to confer claim 7 , enhance claim 7 , improve or modify the odor properties of a perfuming composition or of a perfumed article claim 7 , which method comprises adding to said composition or article an effective amount of the compound of formula (I) as defined in .9. A method of using the compound of formula (I) as defined in claim 7 , the method comprising using the compound of formula (I) as a perfuming ingredient.10. A perfuming composition comprising{'claim-ref': {'@idref': 'CLM-00007', 'claim 7'}, 'i) at least one compound of formula (I) as defined in ;'}ii) at least one ingredient selected from the group consisting of a perfumery carrier and a perfumery base; andiii) optionally at least one perfumery adjuvant.11. A perfumed consumer product comprising at least one compound of formula (I) as defined in .12. The perfumed consumer product according to claim 11 , wherein the product is a perfume claim 11 , a fabric care product claim 11 , a body-care product claim 11 , a cosmetic preparation claim 11 , a skin-care product claim 11 , an air care product or a home care product.13. The perfumed consumer product according to claim 12 , wherein the ...

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Номер записи: 63
20-07-2017 дата публикации

3-(4-ISOBUTYL-2-METHYLPHENYL) PROPANAL AS PERFUME INGREDIENT

Номер: US20170204038A1
Автор: Goeke Andreas, Kraft Philip, LAUE Heike, VOIROL Francis, ZOU Yue
Принадлежит:

A compound according to the formula (I) 2. A perfume composition comprising the compound according to the formula (I) as defined in .3. The perfume composition according to claim 2 , which exhibits muguet odour characteristics.4. The perfume composition according to comprising one or more additional fragrance ingredients.5. The perfume composition according to that is free of aryl-substituted alkanal odourants that are unsubstituted on the aryl ring at a position ortho to the substituent bearing the aldehyde functionality.6. The perfume composition according to that is free of 3-(4-tert-butylphenyl)-2-methylpropanal.7. The perfume composition according to claim 5 , which exhibits muguet odour characteristics.8. The perfume composition according to comprising one or more additional fragrance ingredients.9. A personal care or household care composition comprising a compound of formula (I) according to .10. A personal care or household care composition comprising a perfume composition as defined in .11. A personal care or household care composition comprising a perfume composition as defined in .12. A personal care or household care composition comprising a perfume composition as defined in .13. A method of producing a muguet odour characteristic to a perfume composition comprising the step of adding to said composition the compound as defined in .14. A method of imparting muguet odour characteristics to a composition comprising the step of adding to said composition a compound according to formula (I) as defined in or a perfume composition containing said compound.15. The method according to claim 14 , wherein the composition is a personal care or household care composition.17. The method according to claim 14 , wherein the perfume ingredient has muguet odour characteristics.18. The method according to claim 14 , wherein the composition is a personal care or household care composition. The present application is a continuation of co-pending U.S. Ser. No. 14/888,633, ...

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Номер записи: 64
19-07-2018 дата публикации

COMPOUND HAVING A MUGUET ODOR

Номер: US20180201873A1
Автор: COULOMB Julien
Принадлежит: FIRMENICH SA

The present invention relates to phenylpropanal derivatives of formula (I) 4. A compound according to claim 1 , characterized in that n is 1.5. A compound according to claim 1 , characterized in that one or two of said R claim 1 , Rand Rmay represent a hydrogen atom claim 1 , and the other or others a methyl group.6. A compound according to claim 1 , wherein the compound is 3-[4-(2-hydroxy-2-methylpropyl)phenyl]propanal.7. The compound of formula (I) of claim 1 , wherein the compound is a perfuming ingredient.8. A perfuming composition comprising{'claim-ref': {'@idref': 'CLM-00001', 'claim 1'}, 'i) at least one compound of formula (I) of ;'}ii) at least one ingredient selected from the group consisting of a perfumery carrier and a perfumery base; andiii) optionally at least one perfumery adjuvant.9. A perfuming consumer product comprising at least one compound of formula (I) of .10. A perfuming consumer product according to claim 9 , characterized in that the perfumery consumer product is a perfume claim 9 , a fabric care product claim 9 , a body-care product claim 9 , a cosmetic preparation claim 9 , a skin-care product claim 9 , an air care product or a home care product.11. A perfuming consumer product according to claim 9 , characterized in that the perfumery consumer product is a fine perfume claim 9 , a splash or eau de perfume claim 9 , a cologne claim 9 , an shave or after-shave lotion claim 9 , a liquid or solid detergent claim 9 , a fabric softener claim 9 , a fabric refresher claim 9 , an ironing water claim 9 , a paper claim 9 , a bleach claim 9 , a carpet cleaners claim 9 , curtain-care products a shampoo claim 9 , a coloring preparation claim 9 , a color care product claim 9 , a hair shaping product claim 9 , a dental care product claim 9 , a disinfectant claim 9 , an intimate care product claim 9 , a hair spray claim 9 , a vanishing cream claim 9 , a deodorant or antiperspirant claim 9 , hair remover claim 9 , tanning or sun product claim 9 , nail ...

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Номер записи: 65
04-08-2016 дата публикации

ISOPRENE OLIGOMER, POLYISOPRENE, PROCESSES FOR PRODUCING THESE MATERIALS, RUBBER COMPOSITION, AND PNEUMATIC TIRE

Номер: US20160222418A1
Автор: ICHIKAWA Naoya, Miyagi Yukino, Ohya Norimasa
Принадлежит:

The invention relates to an isoprene oligomer that contains a trans structural moiety and a cis structural moiety, which can be represented by the following formula (1), wherein at least 1 atom or group in the trans structural moiety is replaced by another atom or group. The invention also relates to a polyisoprene, which is biosynthesized using the isoprene oligomer and isopentenyl diphosphate. Further, this invention provides a rubber composition comprising the isoprene oligomer and/or the polyisoprene, and a pneumatic tire, including tire components (e.g., treads and sidewalls) formed from the rubber composition. 5. The isoprene oligomer according to claim 4 , wherein the biosynthesis is carried out using an enzyme that shows prenyltransferase activity.8. The process for producing the isoprene oligomer according to claim 7 , wherein the biosynthesis is carried out using an enzyme showing prenyltransferase activity. This application is a Divisional of copending application Ser. No. 13/809,616, filed on Jan. 11, 2013, which was filed as PCT International Application No. PCT/JP2011/064774 on Jun. 28, 2011, which claims the benefit under 35 U.S.C. §119(a) to Patent Application No. 2010-160120, filed in Japan on Jul. 14, 2010 and Patent Application No. 2010-277384, filed in Japan on Dec. 13, 2010, all of which are hereby expressly incorporated by reference into the present application.The present invention relates to an isoprene oligomer and a polyisoprene; processes for producing these materials; a rubber composition including the isoprene oligomer and/or the polyisoprene; and a pneumatic tire formed from the rubber composition.Conventionally, in order to impart novel properties, in addition to the original properties of rubber, to rubber products, filler and the like of various materials or shapes are introduced into rubber compositions according to the uses to achieve the desired properties. For automobile tires, for example, in order to improve properties such as ...

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Номер записи: 66
03-08-2017 дата публикации

ORGANIC COMPOUNDS

Номер: US20170218299A1
Автор: Goeke Andreas, Kraft Philip, LAUE Heike, VOIROL Francis, ZOU Yue
Принадлежит:

An aryl-substituted alkanal compound having a molecular weight of less than 300 g/mol and which bears a substituent on the aryl ring ortho to a substituent bearing the aldehyde functionality. Said compounds are useful as perfume ingredients in personal care and household care products. 2. A method of utilizing the compound according to as a perfume ingredient exhibiting muguet odour characteristics to a personal care or household care composition comprising the step of adding to said composition the compound or a perfume composition containing said compound.3. A perfume composition comprising the compound as defined in claim 1 , which composition is free of any aryl-substituted alkanal claim 1 , optionally free of any aryl-substituted propanal claim 1 , odourants that are unsubstituted on the aryl ring at a position ortho to the substituent bearing the aldehyde functionality claim 1 , and optionally free of 3-(4-tert-butylphenyl)-2-methylpropanal.4. A personal care or household care composition perfumed with an aryl-substituted alkanal compound according to .5. A personal care or household care composition according to containing enzymes.6. The personal or household care composition according to characterised in that it is a textile treatment product.7. The personal or household care composition according to characterised in that it is a detergent composition.8. A method of imparting muguet odour characteristics to a fine fragrance or consumer product comprising the step of adding thereto an aryl-substituted alkanal compound defined in claim 1 , and selectively excluding from said fine fragrance or consumer product any aryl-substituted alkanal compounds claim 1 , which are unsubstituted on the ring at the position ortho to the substituent containing aldehyde functionality claim 1 , said selective addition or exclusion being based on the susceptibility of said compounds to enzymatically-mediated degradation to their benzoic acid derivatives when incubated with ...

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Номер записи: 67
03-08-2017 дата публикации

Methods and Materials for Producing 7-Carbon Monomers

Номер: US20170218406A1
Автор: Botes Adriana L., Chen Changlin, CONRADIE Alexander Van Eck, Foster Alec
Принадлежит: INVISTA North America S.a.r.l.

This document describes biochemical pathways for producing pimeloyl-CoA using a polypeptide having the enzymatic activity of a hydroperoxide lyase to form non-3-enal and 9-oxononanoate from 9-hydroxyperoxyoctadec-10,12-dienoate. Non-3-enal and 9-oxononanoate can be enzymatically converted to pimeloyl-CoA or a salt thereof using one or more polypeptides having the activity of a dehydrogenase, a CoA ligase, an isomerase, a reductase, a thioesterase, a monooxygenase, a hydratase, and/or a thiolase. Pimeloyl-CoA can be enzymatically converted to pimelic acid, 7-aminoheptanoic acid, 7-hydroxyheptanoic acid, heptamethylenediamine, or 1,7-heptanediol, or corresponding salts thereof. This document also describes recombinant microorganisms producing pimeloyl-CoA, as well as pimelic acid, 7-aminoheptanoic acid, 7-hydroxyheptanoic acid, heptamethylenediamine, and 1,7-heptanediol, or corresponding salts thereof. 1. A method of producing non-3-enal and 9-oxononanoate in a recombinant microorganism , said method comprising enzymatically converting 9-hydroxyperoxyoctadec-10 ,12-dienoate to non-3-enal and 9-oxononanoate using an exogenous polypeptide having the activity of a hydroperoxide lyase classified under EC 4.2.99.- ,said method optionally further comprising enzymatically converting non-3-enal to azelaic acid using one or more polypeptides comprising at least one polypeptide having the activity of a dodecenoyl-CoA isomerase classified under EC 5.3.3.8 or at least one polypeptide having the activity of an enoate reductase classified under EC 1.3.1.31.2. (canceled)3. (canceled)4. The method of claim 1 , said method comprising enzymatically converting non-3-enal to azelaic acid using one or more polypeptides claim 1 , comprising:at least one polypeptide having the activity of a dodecenoyl-CoA isomerase classified under EC 5.3.3.8, wherein said at least one polypeptide having the activity of a dodecenoyl-CoA isomerase classified under EC 5.3.3.8 enzymatically converts non-3- ...

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Номер записи: 68
16-10-2014 дата публикации

OMEGA-HALO-2-ALKYNAL, METHOD FOR PRODUCING SAME, AND METHOD FOR PRODUCING CONJUGATED Z-ALKEN-YN-YL ACETATE USING SAME

Номер: US20140309452A1
Автор: Fukumoto Takehiko, Kinsho Takeshi, Yamashita Miyoshi
Принадлежит: SHIN-ETSU CHEMICAL CO., LTD.

Provided is a method for industrially producing a conjugated Z-alken-yn-yl acetate such as Z-13-hexadecen-11-yn-yl acetate which is a sex pheromone component of a pine processionary moth, and an intermediate for the conjugated Z-alken-yn-yl acetate under mild conditions at a high yield. More specifically, provided is a method for producing a conjugated Z-alken-yn-yl acetate (5) comprising the steps of: reacting an ω-halo-2-alkynal (1) with an alkylidene triphenylphosphorane (3) through a Wittig reaction to obtain a conjugated Z-alken-yn-yl halide (4), and acetoxylating the conjugated Z-alken-yn-yl halide (4) into a conjugated Z-alken-yn-yl acetate (5). 3. The method for producing a conjugated Z-alken-yn-yl acetate according to claim 2 , wherein the conjugated Z-alken-yn-yl acetate is Z-13-hexadecen-11-yn-yl acetate. This application claims priority from Japanese Patent Application No. 2013-083861, filed Apr. 12, 2013, the disclosure of which is incorporated by reference herein in its entirety.The present invention relates to methods for producing a conjugated Z-alken-yn-yl acetate and an ω-halo-2-alkynal which is an intermediate thereof, particularly to a method for producing Z-13-hexadecen-11-yn-yl acetate which is a sex pheromone component of a pine processionary moth (scientific name: ), which is a forest pest insect in Europe.A pine processionary moth (scientific name: ) is an insect widely inhabiting European countries such as France, Italy, Spain, Portugal and Greece. It has become a problem as a forest pest insect because of feeding damage to trees such as pine and cedar. In addition, poisonous hair of the larva of this moth is known to cause a serious allergic reaction in humans, livestock, pets and the like. Moreover, in recent years, the habitat of the moth has been expanding northward from the Mediterranean region due to the effect of global warming. There is therefore a demand for the development of a novel control method of the moth.It has been reported ...

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Номер записи: 69
11-08-2016 дата публикации

Method for Producing Asymmetric Conjugated Diyne Compound and Method for Producing Z,Z-Conjugated Diene Compound Using the Same

Номер: US20160229829A1
Автор: Akihiro Baba, Miyoshi Yamashita, Naoki Ishibashi, Takeshi Kinsho, Yuki Miyake, Yusuke Nagae
Принадлежит: Shin Etsu Chemical Co Ltd

Provided are a method for efficiently producing an asymmetric conjugated diyne from an inexpensive and safe alternative compound to hydroxylamine hydrochloride and a method for producing a Z,Z-conjugated diene compound from the asymmetric conjugated diyne compound thus obtained. More specifically, provided is a method for producing an asymmetric conjugated diyne compound comprising a step of subjecting a terminal alkyne compound (1): HC≡C—Z 1 —Y 1 to a coupling reaction with an alkynyl halide (2) Y 2 —Z 2 —C≡C—X by using sodium borohydride in water and an organic solvent in the presence of a copper catalyst and a base to obtain the asymmetric conjugated diyne compound (3): Y 2 —Z 2 —C≡C—C≡C—Z 1 —Y 1 . In addition, provided is a method for producing a Z,Z-conjugated diene compound by reducing the resulting asymmetric conjugated diyne compound, or the like.

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Номер записи: 70
23-10-2014 дата публикации

PERFUMING INGREDIENTS OF THE FLORAL AND/OR ANIS TYPE

Номер: US20140314699A1
Автор: MORETTI Robert
Принадлежит: FIRMENICH SA

The present invention concerns a compound of formula 2. A compound according to claim 1 , wherein the compound (II) is one wherein R claim 1 , Ror Rrepresents a hydrogen atom or methyl group claim 1 , R represents a hydrogen atom and X represents a CHO.3. A compound according to claim 1 , wherein the compound (I) is (4E)-4-methyl-5-(4-methylphenyl)-4-pentenal claim 1 , (4E)-2 claim 1 ,4-dimethyl-5-(4-methylphenyl)-4-pentenal claim 1 , 2 claim 1 ,4-dimethyl-5-phenyl-4-pentenal claim 1 , 4-methyl-5-phenyl-4-hexenal claim 1 , 4-methyl-5-phenyl-4-pentenal or methyl (4E)-4-methyl-5-(4-methylphenyl)-4-pentenoate.4. The compound according to claim 1 , wherein R claim 1 , Ror Rrepresents a hydrogen atom or methyl group claim 1 , Rrepresents a methyl group and X represents a CHO group.5. The compound according to claim 1 , wherein:R is an ortho, meta or para substituent of the phenyl ring and represents a hydrogen atom or a methyl or ethyl group;{'sup': '1', 'Rrepresents a methyl or ethyl group;'}{'sup': '2', 'Rrepresents a hydrogen atom or a methyl or ethyl group;'}{'sup': '3', 'Rrepresents a hydrogen atom or a methyl or ethyl group; and'}{'sup': 4', '4, 'X represents a CHO, COORor CN group, Rbeing a methyl or ethyl group.'}6. The compound according to associated with or incorporated in a solid or liquid detergent claim 1 , a fabric softener claim 1 , a perfume claim 1 , a cologne or after-shave lotion claim 1 , a perfumed soap claim 1 , a shower or bath salt claim 1 , mousse claim 1 , oil or gel claim 1 , a hygiene product claim 1 , a hair care product claim 1 , a shampoo claim 1 , a body-care product claim 1 , a deodorant or antiperspirant claim 1 , an air freshener claim 1 , a cosmetic preparation claim 1 , a fabric refresher claim 1 , an ironing water claim 1 , a paper claim 1 , a wipe or a bleach. This application is a division of U.S. application Ser. No. 13/123,642 filed Apr. 11, 2011, which is the 371 filing of International Patent Application no. PCT/IB209/054864 ...

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Номер записи: 71
18-07-2019 дата публикации

Myricanol Derivatives and Uses Thereof for Treatment of Neurodegenerative Diseases

Номер: US20190218165A1
Автор: Baker Bill J., Calcul Laurent, Dickey Chad, Jinwal Umesh, Lebar Matthew
Принадлежит:

The subject invention pertains to myricanol derivatives, therapeutic compositions, and methods for treatment of neurodegenerative diseases, in particular, neurodegenerative dieses associated with abnormal accumulation of protein tau. 2. The method according to claim 1 , wherein the compound has a chemical structure of formula G.3. The method according to claim 1 , wherein the compound has a chemical structure of formula H.4. The method according to claim 1 , wherein the compound has a chemical structure of formula I.8. The method according to claim 1 , wherein the cells are in a subject in need of treatment for a neurodegenerative disease.9. The method of claim 1 , wherein the neurodegenerative disease is a tauopathy.10. The method of claim 9 , wherein the subject is a human.11. The method of claim 10 , wherein the neurodegenerative disease is selected from Alzheimer's disease claim 10 , Parkinson's disease claim 10 , frontotemporal dementia claim 10 , frontotemporal dementia with Parkinsonism claim 10 , frontotemporal lobe dementia claim 10 , pallidopontonigral degeneration claim 10 , progressive supranuclear palsy claim 10 , multiple system tauopathy claim 10 , multiple system tauopathy with presenile dementia claim 10 , Wilhelmsen-Lynch disease claim 10 , Pick's disease claim 10 , or Pick's disease-like dementia.12. The method of claim 11 , wherein the neurodegenerative disease is Alzheimer's disease.14. The method according to claim 13 , wherein the compound has a chemical structure of formula G.15. The method according to claim 14 , wherein the compound has a chemical structure of formula H.16. The method according to claim 15 , wherein the compound has a chemical structure of formula I. This application is a divisional of U.S. application Ser. No. 15/993,232, filed May 30, 2018; which is a divisional of U.S. application Ser. No. 15/414,242, filed Jan. 24, 2017; which is a continuation of U.S. application Ser. No. 14/390,960, filed Oct. 6, 2014, now U.S. Pat. ...

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Номер записи: 72
18-07-2019 дата публикации

Continuous Production Method for 2-Methylene Alkanals

Номер: US20190218166A1
Автор: Balzarek Christoph, MEIER Gregor, RAHE Jan-Henry, Schalapski Kurt, Strutz Heinz
Принадлежит:

The present invention relates to the continuous production of 2-methylene alkanals in a tube reactor, wherein in the 2-position non-branched alkanals are reacted with formaldehyde under acid-base catalysis in the presence of secondary amines and carboxylic acids under laminar flow conditions. 2. The method according to claim 1 , wherein the Reynolds number is kept constant within the tube reactor.3. The method according to claim 1 , wherein the liquid/liquid two-phase system is formed by separately introducing at least one organic and at least one aqueous phase in a co-current flow into the tube reactor.4. The method according to claim 1 , wherein the carboxylic acid is introduced into the reactor together with the secondary amine dissolved in an organic solvent.5. The method according claim 4 , wherein the solvent is selected from the group consisting of mono-alcohols with 6 to 12 carbon atoms or mixtures thereof.6. The method according to claim 1 , wherein the reaction is carried out at a temperature of greater than or equal to 70° C. and less than or equal to 150° C.7. The method according to claim 1 , wherein no additional surface-active substances are present in the two-phase system.8. The method according to claim 1 , wherein the tube reactor is operated with a Reynolds number of greater than or equal to 50 and less than or equal to 500.9. The method according to claim 1 , wherein the reactor load V/Vh with respect to the total mass flow of reactants is greater than or equal to 3.0 hand less than or equal to 42.0 h.10. The method according to claim 1 , wherein the carboxylic acid is selected from the group consisting of aliphatic or aromatic C2-C12 monocarboxylic acids.11. The method according to claim 1 , wherein the molar ratio of alkanal claim 1 , formaldehyde in the formalin and secondary amine is in the range from 1:1:0.01 to 1:1.2:0.07.12. The method according to claim 1 , wherein the residue Ris an aliphatic C5-C13 hydrocarbon residue.13. The method ...

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Номер записи: 73
27-08-2015 дата публикации

Oxide catalyst and method for producing the same, and methods for producing unsaturated aldehyde, diolefin, and unsaturated nitrile

Номер: US20150238939A1
Автор: Jun Yoshida, Tatsuo Yamaguchi
Принадлежит: Asahi Kasei Chemicals Corp

An object of the present invention is to provide an oxide catalyst that prevents the reduction degradation of the catalyst even during industrial operation for a long time and less reduces unsaturated aldehyde yields, diolefin yields, or unsaturated nitrile yields, and a method for producing the same, and methods for producing unsaturated aldehyde, diolefin, and unsaturated nitrile using the oxide catalyst. The present invention provides an oxide catalyst for use in the production of unsaturated aldehyde, diolefin, or unsaturated nitrile from olefin and/or alcohol, the oxide catalyst satisfying the following (1) to (3): (1) the oxide catalyst comprises molybdenum, bismuth, iron, cobalt, and an element A having an ion radius larger than 0.96 Å (except for potassium, cesium, and rubidium); (2) an atomic ratio a of the bismuth to 12 atoms of the molybdenum is 1≦a≦5, an atomic ratio b of the iron to 12 atoms of the molybdenum is 1.5≦b≦6, an atomic ratio c of the element A to 12 atoms of the molybdenum is 1≦c≦5, and an atomic ratio d of the cobalt to 12 atoms of the molybdenum is 1≦d≦8; and (3) the oxide catalyst comprises a disordered phase consisting of a crystal system comprising the molybdenum, the bismuth, the iron, and the element A.

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Номер записи: 74
16-08-2018 дата публикации

COMPOSITIONS AND METHODS RELATED TO THE PRODUCTION OF ACRYLONITRILE

Номер: US20180229222A1
Автор: Goyal Amit
Принадлежит:

Disclosed herein is a method useful in the process of contacting a first product that includes ethylene glycol, propylene glycol, and glycerol with the catalyst composition, thereby producing a second product that includes acrolein and acetaldehyde. 1. A method comprising the step of: {'br': None, 'sub': x', 'y', 'z, 'M1M2M3O'}, 'a) contacting a first product comprising ethylene glycol, propylene glycol, and glycerol with the catalyst composition, thereby producing a second product comprising acrolein and acetaldehyde, wherein the catalyst composition comprises a catalyst having the formulawherein M1 is a metal promoting dehydrogenation and C—O cleavage,wherein M2 is a metal with acid sites promoting dehydration,wherein M3 is an amphoteric catalyst support, with acid and base sites, promoting both dehydration and dehydrogenation in conjunction with M1,wherein x is a molar ratio from about 0.25 to about 4,wherein y is a molar ratio from about 0.25 to about 4,wherein z is the total amount of oxygen bound to M1, M2, and M3, and corresponds to the sum of the oxidation states of M1, M2, and M3.2. The method of claim 1 , wherein the method further comprises the steps of:b) separating at least a portion of the acetaldehyde from the second product; andc) following step b) converting at least a portion of the acrolein in the second product to acrylonitrile.3. The method of claim 1 , wherein the first product is produced from C5 and/or C6 sugars in a single step using a multifunctional catalyst.4. The method of claim 3 , wherein the C5 and/or C6 sugars is C5 and/or C6 hemicellulose and cellulose derived sugars.5. The method of claim 1 , wherein from about 10 wt % to about 90 wt % of the propylene glycol and glycerol in the first product are converted to acrolein.6. The method of claim 1 , wherein the second product comprises from about 20 wt % to about 75 wt % of acrolein.7. The method of claim 3 , wherein the multifunctional catalyst comprises one or more metals selected ...

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Номер записи: 75
16-08-2018 дата публикации

ORGANIC COMPOUNDS

Номер: US20180230399A1
Автор: Goeke Andreas, LAUE Helke, Natsch Andreas, VOIROL Francis
Принадлежит:

The use of a compound represented by the formula I 2. The perfume ingredient according to claim 1 , wherein the compound has muguet odour characteristics.6. A perfume composition according to that is free of any aryl-substituted propanal claim 5 , odourants that are unsubstituted on the aryl ring at a position ortho to the substituent bearing the aldehyde functionality and/or not bearing butanal as the aldehyde functionality claim 5 , in particular Lilial™.7. A perfume composition according to comprising one or more additional fragrance ingredients selected from: 3-(4-isobutyl-2-methylphenyl)propanal and 3-(4-(tert-butyl)-2-methylphenyl)-2-methylpropanal.9. A personal care or household care composition according to claim 8 , further comprising enzymes.10. A personal or household care composition according to which is a textile treatment product.11. A personal or household care composition according to which is a detergent composition.13. The pro-perfume of claim 4 , which is an aminal and/or enamine of the compound represented by the formula I.14. A personal care or household care composition comprising a perfume composition according to .15. A personal care or household care composition comprising a perfume composition according to .16. A personal care or household care composition comprising a perfume composition according to . This invention relates to perfume ingredients and perfume preparations containing same. In particular, the invention relates to said perfume ingredients or perfume preparations that exhibit muguet (lily of the valley) odour characteristics. Still more particularly, the invention relates to said perfume preparations that contain no, or substantially no, Lilial™. The invention further relates to methods of making said perfume ingredients and perfume preparations, as well as the use of said perfume ingredients and perfume preparations in fine fragrances and consumer products, such as personal care and household care products. The invention ...

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Номер записи: 76
25-07-2019 дата публикации

LILY OF THE VALLEY ODORANT

Номер: US20190225913A1
Автор: Chapuis Christian
Принадлежит:

The present invention concerns a compound of formula (I) in the form of any one of its stereoisomers or as a mixture thereof, and wherein carbon 4 of the cyclohexenyl group has an absolute S configuration and R represents a hydrogen atom or a methyl group and their use in perfumery to impart odor notes of white peach and floral type. 3. A method to confer claim 1 , enhance claim 1 , improve or modify the odor properties of a perfuming composition or of a perfumed article claim 1 , which method comprises adding to said composition or article an effective amount of at least a compound of formula (I) as defined in .4. A perfuming ingredient comprising a compound of formula (I) as defined in .5. A perfuming composition comprising{'claim-ref': {'@idref': 'CLM-00001', 'claim 1'}, 'i) at least one compound of formula (I), as defined in ;'}ii) at least one ingredient selected from the group consisting of a perfumery carrier and a perfumery base; andiii) optionally at least one perfumery adjuvant.6. A perfumed consumer product comprising at least one compound of formula (I) claim 1 , as defined in .7. The perfumed consumer product according to claim 6 , wherein the product is a perfume claim 6 , a fabric care product claim 6 , a body-care product claim 6 , a cosmetic preparation claim 6 , a skin-care product claim 6 , an air care product or a home care product.8. The perfumed consumer product according to claim 7 , wherein the perfumery consumer product is a fine perfume claim 7 , a splash or eau de perfume claim 7 , a cologne claim 7 , an shave or after-shave lotion claim 7 , a liquid or solid detergent claim 7 , a fabric softener claim 7 , a fabric refresher claim 7 , an ironing water claim 7 , a paper claim 7 , a bleach claim 7 , a carpet cleaner claim 7 , a curtain-care product claim 7 , a shampoo claim 7 , a coloring preparation claim 7 , a color care product claim 7 , a hair shaping product claim 7 , a dental care product claim 7 , a disinfectant claim 7 , an intimate ...

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Номер записи: 77
16-07-2020 дата публикации

CYCLAMEN ODORANT

Номер: US20200224119A1
Автор: BIRKBECK Anthony Alexander, Chapuis Christian
Принадлежит:

Described herein are compounds of formula (I) 3. The compound according claim 1 , characterized in that one Ris a hydrogen atom and the other two Rmay each independently be a hydrogen atom or a methyl group.4. The compound according to claim 1 , characterized in that Ris a hydrogen atom.5. The compound according to claim 1 , characterized in that Ris a methyl claim 1 , an ethyl or an isopropyl group.6. The compound according to claim 1 , characterized in that Ris a methyl claim 1 , an ethyl or a propyl group.7. The compound according to claim 1 , characterized in that Rand R claim 1 , when taken together claim 1 , is a Clinear alkanediyl group or a Cbranched alkanediyl group.8. The compound according to claim 1 , characterized in that the compound of formula (I) is 3-(4-ethyl-4-methyl-1-cyclohexen-1-yl)propanal claim 1 , 3-spiro[4.5]dec-7-en-8-ylpropanal claim 1 , 3-(spiro[5.5]undec-2-en-3-yl)propanal or 3-(4 claim 1 ,4-diethylcyclohex-1-en-1-yl)propanal.9. A method to confer claim 1 , enhance claim 1 , improve or modify the odor properties of a perfuming composition or of a perfumed article claim 1 , wherein the method comprises adding to said perfuming composition or perfumed article an effective amount of at least a compound of formula (I) as defined in .10. A method of using the compound of formula (I) as defined in claim 1 , the method comprising using the compound of formula (I) as a perfuming ingredient.11. A perfuming composition comprising{'claim-ref': {'@idref': 'CLM-00001', 'claim 1'}, 'i) at least one compound of formula (I), as defined in ;'}ii) at least one ingredient selected from the group consisting of a perfumery carrier and a perfumery base; andiii) optionally at least one perfumery adjuvant.12. A perfumed consumer product comprising at least one compound of formula (I) claim 1 , as defined in .13. The perfumed consumer product according to claim 12 , characterized in that the product is a perfume claim 12 , a fabric care product claim 12 , a body ...

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Номер записи: 78
25-08-2016 дата публикации

SIDE-CHAIN VARIANTS OF REDOX-ACTIVE THERAPEUTICS FOR TREATMENT OF MITOCHONDRIAL DISEASES AND OTHER CONDITIONS AND MODULATION OF ENERGY BIOMARKERS

Номер: US20160244392A1
Автор: HECHT Sidney M., JANKOWSKI Orion D., Miller Guy M., MOLLARD Paul, WESSON Kieron E.
Принадлежит:

Methods of treating or suppressing mitochondrial diseases, such as Friedreich's ataxia (FRDA), Leber's Hereditary Optic Neuropathy (LHON), mitochondrial myopathy, encephalopathy, lactacidosis, stroke (MELAS), or Kearns-Sayre Syndrome (KSS) are disclosed, as well as compounds useful in the methods of the invention. Methods and compounds useful in treating other disorders are also disclosed. Energy biomarkers useful in assessing the metabolic state of a subject and the efficacy of treatment are also disclosed. Methods of modulating, normalizing, or enhancing energy biomarkers, as well as compounds useful for such methods, are also disclosed. 145-. (canceled)47. The compound of claim 46 , wherein R claim 46 , R claim 46 , and Rare independently selected from the group consisting of —H claim 46 , —C-Calkyl claim 46 , —C-Chaloalkyl claim 46 , —C-Calkenyl claim 46 , —C-Chaloalkenyl claim 46 , —C-Calkynyl claim 46 , and —C-Chaloalkynyl claim 46 , and where at least one of R claim 46 , R claim 46 , and Ris independently selected from the group consisting of —C-Calkyl claim 46 , —C-Chaloalkyl claim 46 , —C-Calkenyl claim 46 , —C-Chaloalkenyl claim 46 , —C-Calkynyl claim 46 , and —C-Chaloalkynyl.48. The compound of claim 47 , wherein at least one of R claim 47 , R claim 47 , and Ris independently selected from the group consisting of —C-Calkyl claim 47 , —C-Chaloalkyl claim 47 , —C-Calkenyl claim 47 , —C-Chaloalkenyl claim 47 , —C-Calkynyl claim 47 , and —C-Chaloalkynyl.49. The compound of claim 46 , wherein at least two of R claim 46 , R claim 46 , and Rare independently selected from the group consisting of —C-Calkyl claim 46 , —C-Chaloalkyl claim 46 , —C-Calkenyl claim 46 , —C-Chaloalkenyl claim 46 , —C-Calkynyl claim 46 , and —C-Chaloalkynyl.50. The compound of claim 49 , wherein R claim 49 , R claim 49 , and Rare independently selected from the group consisting of —C-Calkyl claim 49 , —C-Chaloalkyl claim 49 , —C-Calkenyl claim 49 , —C-Chaloalkenyl claim 49 , —C-Calkynyl ...

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Номер записи: 79
30-08-2018 дата публикации

METHOD OF PRODUCING ORGANIC COMPOUND

Номер: US20180244604A1
Автор: HAGA Yayoi, KAWAMOTO Fumio, KEMMOKU Akira
Принадлежит: FUJIFILM FINECHEMICALS CO., LTD.

A method of producing an organic compound, which contains a step of performing a deodorization step using a flow reaction in a flow passage to remove, from a reaction liquid, a malodorous material generated or remaining in a reaction step, 1. A method of producing an organic compound , comprising:performing a deodorization using a flow reaction in a flow passage to remove, from a reaction liquid, a malodorous material generated or remaining in a reaction,wherein the organic compound is an industrially useful compound.2. The production method according to claim 1 , wherein the reaction is an oxidation reaction using a sulfur atom-containing organic compound.3. The production method according to claim 1 , wherein claim 1 , in the reaction claim 1 , an alcohol compound having 2 to 50 carbon atoms is oxidized to produce an aldehyde or ketone compound having 2 to 50 carbon atoms.4. The production method according to claim 2 , wherein the oxidation reaction using a sulfur-atom-containing organic compound is an oxidation reaction using a dialkyl sulfoxide compound having 2 to 8 carbon atoms claim 2 , and an acid anhydride having 4 to 10 carbon atoms or an acid halide having 2 to 7 carbon atoms.5. The production method according to claim 1 , wherein the malodorous material is a dialkyl sulfide having 2 to 8 carbon atoms.6. The production method according to claim 1 , wherein the deodorization is an oxidation reaction of the malodorous material.7. The production method according to claim 1 , wherein the deodorization is an oxidation reaction in which the malodorous material is oxidized by using an oxidizing agent selected from the group consisting of hypochlorous acid or a salt thereof claim 1 , a halogenating agent claim 1 , and peracetic acid.8. The production method according to claim 7 , wherein an amount of the oxidizing agent is 0.5 to 5.0 molar equivalents claim 7 , based on an amount of the acid anhydride or the acid halide in the reaction.9. The production method ...

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Номер записи: 80
08-09-2016 дата публикации

PROCESSES FOR PREPARING (R)-1-(5-CHLORO-[1,1`-BIPHENYL]-2-YL)-2,2,2-TRIFLUOROETHANOL AND 1-(5-CHLORO-[1,1`-BIPHENYL]-2-YL)-2,2,2-TRIFLUOROETHANONE

Номер: US20160257633A1
Автор: DE LOMBAERT Stephane, Goldberg Daniel R.
Принадлежит:

The present invention relates to processes for the preparation of (R)-1-(5-chloro-[1,1′-biphenyl]-2-yl)-2,2,2-trifluoroethanol, 1-(5-chloro-[1,1′-biphenyl]-2-yl)-2,2,2-trifluoroethanone, and intermediates thereof, which are useful in the preparation of inhibitors of TPH1 for the treatment of, for example, gastrointestinal, cardiovascular, pulmonary, inflammatory, metabolic, low bone mass diseases, serotonin syndrome, and cancer. 2. The process of claim 1 , wherein said reacting is carried out under Suzuki coupling conditions.3. The process of claim 1 , wherein said reacting is carried out in the presence of a Pd catalyst.4. The process of wherein said Pd catalyst is Pd(dppf)Cl.5. The process of claim 1 , wherein said reacting is carried out in the presence of a solvent.6. The process of wherein said solvent comprises dioxane.7. The process of wherein said solvent comprises aqueous sodium carbonate.8. The process of claim 1 , wherein said reacting is carried out at elevated temperature.9. The process of claim 8 , wherein said elevated temperature is about 90° C.11. The process of claim 10 , wherein said chiral catalyst comprises iridium.12. The process of claim 10 , wherein said chiral catalyst is prepared by combining dichloro(pentamethylcyclopentadienyl)iridium(III) dimer with (1R claim 10 ,2R)-(−)-N-(4-toluenesulfonyl)-1 claim 10 ,2-diphenylethylenediamine.13. The process of claim 10 , wherein said reducing is carried out at elevated temperature.14. The process of wherein said elevated temperature is about 40° C.15. The process of claim 10 , wherein said reducing is carried out in the presence of formate.16. The process of claim 15 , wherein said formate is potassium formate.17. The process of claim 10 , wherein said reducing is carried out in the presence of a solvent.18. The process of claim 17 , wherein said solvent comprises acetonitrile.20. The process of claim 19 , wherein said combining is carried out in the presence of CsF.21. The process of claim 19 , ...

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Номер записи: 81
06-09-2018 дата публикации

SYNTHESIS OF METHACRYLIC ACID FROM METHACROLEIN-BASED ALKYL METHACRYLATE

Номер: US20180251418A1
Автор: Groemping Matthias, KRILL Steffen, LYGIN Alexander
Принадлежит: Evonik Roehm GmbH

The present invention relates to a process for preparing alkyl methacrylates, especially MMA, and methacrylic acid, based on methacrolein, which has been oxidatively esterified in a second process stage. Methacrolein is obtainable in principle from Cand Cunits. The present process has the advantage that the alkyl methacrylate and methacrylic acid can be obtained in a simple manner, in high yields and high purities, either as a mixture or as isolated product streams. In particular, the process of the invention has the great advantage that especially the ratio of the desired methacrylic acid and alkyl methacrylate, especially MMA, products can be adjusted freely within a wide range and varied by chemical engineering measures and operating parameters. 1. A process for preparing at least one alkyl methacrylate and methacrylic acid , the process comprising:a) synthesizing methacrolein in a reactor I,b) carrying out oxidative esterification of methacrolein with an alcohol and oxygen to give an alkyl methacrylate in a reactor II ande) reacting at least a portion of the alkyl methacrylate with water to give methacrylic acid in a reactor III.2. The process according to claim 1 , comprising:c) removing excess methacrolein and at least partially removing the alcohol, optionally followed by treating with an acid and/or by carrying out phase separation of an alkyl methacrylate-containing composition,d) of separating the alkyl methacrylate-containing composition and optionally a methacrylic acid-containing composition with supply of water as an organic phase from an aqueous phase in an extraction I,f) transferring a composition comprising the methacrylic acid and the alkyl methacrylate from e) into the extraction I andg) of optionally separating the methacrylic acid from the alkyl methacrylate in a separation stage M.32. The process according to or claim 1 ,wherein water of reaction formed in b) is separated from the alkyl methacrylate between b) and e) and fed wholly or partly ...

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Номер записи: 82
06-09-2018 дата публикации

ORGANIC COMPOUNDS

Номер: US20180251706A1
Автор: Goeke Andreas, Kraft Philip, LAUE Heike, VOIROL Francis, ZOU Yue
Принадлежит:

An aryl-substituted alkanal compound having a molecular weight of less than 300 g/mol and which bears a substituent on the aryl ring ortho to a substituent bearing the aldehyde functionality. Said compounds are useful as perfume ingredients in personal care and household care products. 1. A personal care or household care composition perfumed with an aryl-substituted alkanal compound having a molecular weight of less than 300 g/mol and which bears a substituent on the aryl ring ortho to a substituent bearing the aldehyde functionality , which composition is free of any aryl-substituted alkanal odourants that are unsubstituted on the aryl ring at a position ortho to the substituent bearing the aldehyde functionality , and is optionally free of 3-(4-tert-butylphenyl)-2-methylpropanal.2. The personal care or household care composition according to claim 1 , which is free of any aryl-substituted propanal odourants that are unsubstituted on the aryl ring at a position ortho to the substituent bearing the aldehyde functionality.3. The personal care or household care composition according to claim 1 , which is free of 3-(4-tert-butylphenyl)-2-methylpropanal.4. The personal care or household care composition according to claim 1 , containing enzymes.5. The personal or household care composition according to claim 4 , characterised in that it is a textile treatment product.6. The personal or household care composition according to claim 4 , characterised in that it is a detergent composition.7. The personal care or household care composition according to claim 1 , perfumed with a compound selected from the group consisting of 3-(4-(tert-butyl)-2-methylphenyl)propanal and 3-(4-isopropyl-2-methylphenyl)propanal.8. A method of imparting muguet odour characteristics to a fine fragrance or consumer product comprising the step of adding thereto an aryl-substituted alkanal compound having a molecular weight of less than 300 g/mol and which bears a substituent on the aryl ring ortho ...

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Номер записи: 83
15-08-2019 дата публикации

COMPOSITION HAVING A MUGUET ODOR

Номер: US20190249111A1
Автор: COULOMB Julien, WALTHER Eric
Принадлежит:

A composition of matter including: 4. The composition according to claim 1 , wherein Ris a hydrogen atom.5. The composition according to claim 1 , wherein n is 1.6. The composition according to claim 1 , wherein the composition comprises 2-(4-(2-hydroxy-2-methylpropyl)phenyl)propanal and 3-(4-(2-hydroxy-2-methylpropyl)phenyl)propanal.7. The composition according to ; wherein the composition comprises 3-[4-(2-hydroxy-2-methylpropyl)phenyl]propanal in an amount comprised between 50% w/w and 99% w/w and 2-[4-(2-hydroxy-2-methylpropyl)phenyl]propanal in an amount comprised between 0.5% w/w and 49% w/w claim 6 , relative to the weight of the composition of matter.8. (canceled)9. A perfuming composition comprising{'claim-ref': {'@idref': 'CLM-00001', 'claim 1'}, 'i) at least a composition of matter as defined in ;'}ii) at least one ingredient selected from the group consisting of a perfumery carrier and a perfumery base; andiii) optionally at least one perfumery adjuvant.10. A perfuming consumer product comprising at least a composition of matter as defined in .11. The perfuming consumer product according to claim 10 , wherein the perfumery consumer product is a perfume claim 10 , a fabric care product claim 10 , a body-care product claim 10 , a cosmetic preparation claim 10 , a skin-care product claim 10 , an air care product or a home care product.12. A perfuming consumer product according to claim 11 , wherein the perfumery consumer product is a fine perfume claim 11 , a splash or eau de perfume claim 11 , a cologne claim 11 , an shave or after-shave lotion claim 11 , a liquid or solid detergent claim 11 , a fabric softener claim 11 , a fabric refresher claim 11 , an ironing water claim 11 , a paper claim 11 , a bleach claim 11 , a carpet cleaners claim 11 , curtain-care products a shampoo claim 11 , a coloring preparation claim 11 , a color care product claim 11 , a hair shaping product claim 11 , a dental care product claim 11 , a disinfectant claim 11 , an intimate ...

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Номер записи: 84
13-09-2018 дата публикации

CATALYST FOR DEHYDRATION OF GLYCERIN, PREPARATION METHOD THEREOF, AND PRODUCTION METHOD OF ACROLEIN USING THE CATALYST (AS AMENDED)

Номер: US20180257063A1
Автор: Cheon Joo Young, CHOI Jun Seon, JOE Wang Rae, KIM Ji Yeon, Kim Kyung Soo, OK Hye Jeong
Принадлежит:

The present disclosure relates to a catalyst for dehydration of glycerin, a preparation method thereof, and a production method of acrolein using the catalyst. 1. A catalyst for dehydration of glycerin represented by the following Chemical Formula 1:{'br': None, 'sub': a', 'b', 'c', 'd', 'e', 'x', 'y, 'sup': 1', '2, 'Zr(M)(M)WPHO\u2003\u2003[Chemical Formula 1]'}wherein, in Chemical Formula 1,{'sup': 1', '2, 'Mand Mare the same as or different from each other, and are independently V, Fe, Nb, Zn, or a combination thereof;'}a, b, c, d, and e represent ratios of atoms, wherein a is 0.1 to 6, b/a is 0 to 1, c/a is 0 to 1, d/a is 0 to 1, and e/a is 0 to 10, provided that at least one of b and c is not 0; andx and y are values determined according to a bonding state of crystallization water, and are independently 0 to 10.2. The catalyst for dehydration of glycerin according to claim 1 , wherein a is 0.5 to 1 claim 1 , b is 0.01 to 0.3 claim 1 , c is 0.01 to 0.3 claim 1 , d is 0.01 to 0.3 claim 1 , and e is 1 to 5.3. The catalyst for dehydration of glycerin according to claim 1 , wherein the catalyst is ZrZnWPHO claim 1 , ZrFeWPHO claim 1 , ZrVWPHO claim 1 , ZrNbFeWPHO claim 1 , ZrZnFeWPHO claim 1 , ZrZnVWPHO claim 1 , ZrZnVWPHO claim 1 , ZrZn(FeV)WPHO claim 1 , ZrZnFeWPHO claim 1 , ZrZnVWPHO claim 1 , or ZrZnVWPHO claim 1 , wherein x may be 2 to 6 claim 1 , and y may be 1 to 3.4. A preparation method of a catalyst for dehydration of glycerin claim 1 , comprising the step of mixing one or more precursors selected from the group consisting of precursors of V claim 1 , Fe claim 1 , Nb claim 1 , and Zn claim 1 , a zirconium precursor claim 1 , a phosphorus precursor claim 1 , and a tungsten precursor claim 1 , followed by drying and calcining to produce a catalyst represented by the following Chemical Formula 1:{'br': None, 'sub': a', 'b', 'c', 'd', 'e', 'x', 'y, 'sup': 1', '2, 'Zr(M)(M)WPHO\u2003\u2003[Chemical Formula 1]'}wherein, in Chemical Formula 1,{'sup': 1', '2, ' ...

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Номер записи: 85
06-08-2020 дата публикации

NOVEL COMPOUNDS AND PROCESS FOR PREPARATION OF THE SAME FROM CASHEW NUT SHELL LIQUID (CNSL)

Номер: US20200247834A1
Автор: CHIKKALI Samir Hujur, Pandey Swechchha
Принадлежит: COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH

The present invention relates to isomerizing hydroformylation of plant oils to feedstock chemicals and monomers. More particularly, the present invention relates to compound of formula (I) and process for preparation thereof using isomerizing functionalization of cashew nut shell liquid (CNSL). 2. The compound as claimed in claim 1 , wherein said compound is selected from 16-3(hydroxyphenyl) hexadecanal and is 16-(3-methoxyphenyl) hexadecanal.3. The compound as claimed in claim 1 , wherein said compound used as monomer to synthesize polymers or copolymers.4. A process for the preparation of compound of formula (I) comprising the steps of:a) adding catalyst to a solution of cardanol in solvent followed by refluxing the reaction mixture for the period in the range of 16 to 18 hrs at temperature in the range of 85 to 90° C. to obtain monoene;b) adding metal precursor and ligand to the mixture of monoene of step (a) in suitable solvent followed by pressurizing and heating the reaction mixture at temperature in the range of 100 to 125° C. for the period in the range of 16 to 48 hours to afford corresponding aldehyde compound of formula (I) andc) optionally reacting monoene of step (a) and potassium carbonate in solvent followed by adding alkyl iodide to the mixture and refluxed for the period in the range of 4 to 6 hrs at temperature in the range of 56 to 60° C. to afford alkyl-protected monoene.5. The process as claimed in claim 4 , wherein said catalyst of step (a) is Ruthenium(III) chloride (RuCl).6. The process as claimed in claim 4 , wherein said metal precursor of step (b) is (Acetylacetonato)dicarbonylrhodium(I).7. The process as claimed in claim 4 , wherein said ligand of step (b) is selected from 1 claim 4 ,2-Bis(di-tert-butylphosphinomethyl)benzene claim 4 , 1 claim 4 ,3-phenylenetetra(naphthalen-1-yl) bis(phosphite)-L2 claim 4 , Xantphos claim 4 , 2 claim 4 ,2′-Bis(diphenylphosphino)-1 claim 4 ,1′-binaphthalene.8. The process as claimed in claim 4 , wherein ...

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Номер записи: 86
13-09-2018 дата публикации

PERFUME SYSTEMS

Номер: US20180258371A1
Автор: Denutte Hugo Robert Germain, Pintens An, Smets Johan, VAN AKEN Koen, Vrielynck Freek Annie Camiel
Принадлежит:

The present application relates to perfume raw materials, perfume delivery systems and consumer products comprising such perfume raw materials and/or such perfume delivery systems, as well as processes for making and using such perfume raw materials, perfume delivery systems and consumer products. Such perfume raw materials and compositions, including the delivery systems, disclosed herein expand the perfume communities' options as such perfume raw materials can provide variations on character and such compositions can provide desired odor profiles. 2. A perfume according to comprising claim 1 , based on total perfume weight claim 1 , from about 0.0001% to about 50% of said perfume raw material.3. A consumer product comprising the perfume according to and an adjunct ingredient.4. A consumer product comprising the perfume according to claim 2 , said consumer product being a cleaning and/or treatment composition and comprising an adjunct ingredient.5. A consumer product according to claim 4 , said consumer product being a fabric and/or hard surface cleaning and/or treatment composition claim 4 , said composition comprising claim 4 , based on total composition weight claim 4 , from about 0.00001% to about 35% of said perfume.6. A consumer product according to claim 4 , said consumer product being a detergent claim 4 , said detergent comprising claim 4 , based on total detergent weight claim 4 , from about 0.00001% to about 35% of said perfume.7. A consumer product according to claim 4 , said consumer product being a highly compacted consumer product claim 4 , said highly compacted consumer product comprising claim 4 , based on total highly compacted consumer product weight claim 4 , from about 0.00001% to about 35% of said perfume.8. A perfume delivery system comprising claim 1 , based on total delivery system weight claim 1 , from about 0.001% to about 99% of the perfume of claim 1 , said perfume delivery system being a polymer assisted delivery system; a molecule- ...

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Номер записи: 87
20-09-2018 дата публикации

Myricanol Derivatives and Uses Thereof for Treatment of Neurodegenerative Diseases

Номер: US20180265442A1
Автор: Baker Bill J., Calcul Laurent, Dickey Chad, Jinwal Umesh, Lebar Matthew
Принадлежит:

The subject invention pertains to myricanol derivatives, therapeutic compositions, and methods for treatment of neurodegenerative diseases, in particular, neurodegenerative dieses associated with abnormal accumulation of protein tau. 2. The method according to claim 1 , wherein the compound has a chemical structure of formula G.3. The method according to claim 1 , wherein the compound has a chemical structure of formula B.4. The method according to claim 1 , wherein the compound has a chemical structure of formula H.7. The method according to claim 1 , wherein the cells are in a subject in need of treatment for a neurodegenerative disease.8. The method of claim 7 , wherein the neurodegenerative disease is a tauopathy.9. The method of claim 8 , wherein the subject is a human.10. The method of claim 9 , wherein the neurodegenerative disease is selected from Alzheimer's disease claim 9 , Parkinson's disease claim 9 , frontotemporal dementia claim 9 , frontotemporal dementia with Parkinsonism claim 9 , frontotemporal lobe dementia claim 9 , pallidopontonigral degeneration claim 9 , progressive supranuclear palsy claim 9 , multiple system tauopathy claim 9 , multiple system tauopathy with presenile dementia claim 9 , Wilhelmsen-Lynch disease claim 9 , Pick's disease claim 9 , and Pick's disease-like dementia.11. The method of claim 10 , wherein the neurodegenerative disease is Alzheimer's disease. This application is a divisional of U.S. application Ser. No. 15/414,242, filed Jan. 24, 2017; which is a continuation of U.S. application Ser. No. 14/390,960, filed Oct. 6, 2014, now U.S. Pat. No. 9,598,338, issued Mar. 21, 2017; which is the U.S. national stage application of International Patent Application No. PCT/US2013/035628, filed Apr. 8, 2013; which claims the benefit of U.S. provisional application Ser. No. 61/621,278, filed Apr. 6, 2012; and 61/678,409, filed Aug. 1, 2012; which are herein incorporated by reference in their entirety.Intracellular aggregation of ...

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Номер записи: 88
20-08-2020 дата публикации

Production of fatty olefin derivatives via olefin metathesis

Номер: US20200261898A1
Автор: Hasan MEHDI, Keith M. WAMPLER, Levente Ondi, Pedro COELHO, Peter Meinhold, Vu Bui
Принадлежит: Provivi Inc

In one aspect, the invention provides a method for synthesizing a fatty olefin derivative. The method includes: a) contacting an olefin according to Formula I with a metathesis reaction partner according to Formula IIb in the presence of a metathesis catalyst under conditions sufficient to form a metathesis product according to Formula IIIb: and b) converting the metathesis product to the fatty olefin derivative. Each R 1 is independently selected from H, C 1-18 alkyl, and C 2-18 alkenyl; R 2b is C 1-8 alkyl; subscript y is an integer ranging from 0 to 17; and subscript z is an integer ranging from 0 to 17. In certain embodiments, the metathesis catalyst is a tungsten catalyst or a molybdenum catalyst. In various embodiments, the fatty olefin derivative is a pheromone. Pheromone compositions and methods of using them are also described.

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Номер записи: 89
27-09-2018 дата публикации

METHOD FOR THE HYDROFORMYLATION OF 2-SUBSTITUTED BUTADIENES AND THE PRODUCTION OF SECONDARY PRODUCTS THEREOF, ESPECIALLY AMBROX

Номер: US20180273458A1
Автор: BREUER MICHAEL, Hofmann Peter, Paciello Rocco, REIN Christian, Rüdenauer Stefan, Schmidt Sebastian, SIEGEL Wolfgang, Strautmann Julia, WEINGARTEN Melanie
Принадлежит: RUPRECHT-KARLS-UNIVERSITAT HEIDELBERG

The present invention relates to a method for the regioselective hydroformylation of polyunsaturated acyclic hydrocarbons, which are 1, 3 butadienes, which, in the 2 position, bear a saturated or monounsaturated or polyunsaturated acyclic hydrocarbon radical. The present invention also relates to the production of secondary products of these hydroformylation products, especially of ambrox. 116.-. (canceled)20. The process according to claim 17 , wherein the compounds of the formula (II) have only one vinyl group in the molecule.21. The process according to claim 17 , wherein the compound of the general formula (II) is selected from the group consisting of isoprene claim 17 , β-myrcene and β-farnesene.22. The process according to claim 17 , wherein the reaction mixture obtained in the hydroformylation (step a)) comprises at least 55% by weight claim 17 , based on the total weight of the reaction mixture claim 17 , of at least one compound of the general formula (I).23. The process according to claim 17 , wherein the reaction mixture obtained in the hydroformylation (step a)) comprises at least 60% by weight claim 17 , based on the total weight of the reaction mixture claim 17 , of at least one compound of the general formula (I).24. The process according to claim 17 , wherein the reaction mixture obtained in the hydroformylation (step a)) comprises at least 65% by weight based on the total weight of the reaction mixture claim 17 , of at least one compound of the general formula (I).25. The process according to claim 17 , comprising at least one reaction step in which β-farnesene is subjected to a reaction with carbon monoxide and hydrogen in the presence of a hydroformylation catalyst (=step a)) claim 17 , wherein a reaction mixture is obtained which comprises at least 50.1% by weight claim 17 , based on the total weight of the reaction mixture claim 17 , of (7E)-8 claim 17 ,12-dimethyl-4-methylenetrideca-7 claim 17 ,11-dienal.26. The process according to claim 17 , ...

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Номер записи: 90
20-08-2020 дата публикации

Carbidopa prodrugs

Номер: US20200262852A1
Автор: Alexander D. HUTERS, Benoit CARDINAL-DAVID, Brian P. ENRIGHT, Christopher P. Miller, Eric A. Voight, Geoff Zhang, James Stambuli, Kassibla E. Dempah, Mark A. Matulenko, Peter T. Mayer, Philip R. Kym, Raimundo Ho, Rodger F. Henry, Russell C. Klix, Scott W. KRABBE, Sean E. MACKEY, Valentino J. Stella, Vincent S. Chan, Xiaochun Lou, Yanbin Lao, Ye Huang, ZHI Wang
Принадлежит: AbbVie Inc

The present disclosure relates to (a) carbidopa prodrugs, (b) pharmaceutical combinations and compositions comprising a carbidopa prodrug and/or an L-dopa prodrug, and (c) methods of treating Parkinson's disease and associated conditions comprising administering a carbidopa prodrug and an L-dopa prodrug to a subject with Parkinson's disease.

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Номер записи: 91
25-11-2021 дата публикации

CONTINUOUS PROCESS FOR PREPARING METHACROLEIN

Номер: US20210363089A1
Автор: Balduf Torsten, BURGHARDT Rudolf, GRÖMPING Matthias, KRILL Steffen, LYGIN Alexander
Принадлежит: Röhm GmbH

Methacrolein is prepared in a continuous process by a Mannich condensation reaction of formaldehyde with propanal. A methacrolein polymerization inhibitor is introduced during the production process and a part thereof is recycled back into the reactor where the Mannich condensation reaction is carried out. 1: A continuous process for preparing methacrolein by a Munich condensation reaction of formaldehyde with propanal , said comprising:introducing a methacrolein polymerization inhibitor into a production process system, andrecycling a part of said methacrolein polymerization inhibitor back into a reactor where the Mannich condensation reaction is carried out,said production process system comprising flow lines, a reactor, a distillation column, a reboiler, a condenser, and a phase separator.2: The continuous process for preparing methacrolein according to claim 1 , wherein the methacrolein polymerization inhibitor is introduced into the distillation column in the production process system.3: The continuous process for preparing methacrolein according to claim 2 , wherein the methacrolein polymerization inhibitor is introduced into the distillation column at an upper portion thereof.4: The continuous process for preparing methacrolein according to claim 3 , wherein a temperature at the upper portion of the distillation column is in the range from 40 to 85° C.5: The continuous process for preparing methacrolein according to claim 1 , wherein the methacrolein polymerization inhibitor is introduced into a flow line connecting an upper portion of the distillation column and the condenser in the production process system.6: The continuous process for preparing methacrolein according to claim 1 , wherein the methacrolein polymerization inhibitor is introduced into a flow line connecting the condenser with the phase separator in the production process system.7: The continuous process for preparing methacrolein according to claim 1 , wherein the methacrolein polymerization ...

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Номер записи: 92
06-10-2016 дата публикации

COMPOUND WITH A WOODY ODOUR

Номер: US20160289595A1
Автор: Chapuis Christian
Принадлежит: FIRMENICH SA

The present invention concerns 2-methyl-5-[2-methyl-3-methylene-bicyclo[2.2.1]hept-5-en-2-yl)]-2-penten-1-ol in any of its stereometric forms or a lower ester thereof and their use as perfuming ingredient, in particular to impart sandalwood and cedar wood notes. 2. A compound according to claim 1 , wherein R is a hydrogen atom.3. A compound according to claim 1 , wherein said compound is in the form of a mixture of stereoisomers comprising more than 50% (w/w) of the (1SR claim 1 ,2SR claim 1 ,4RS) stereoisomer and of a mixture of isomers E and Z wherein said isomers Z represent at least 75% of the total mixture.4. A compound according to claim 1 , wherein said compound is (−)-(2Z)-2-methyl-5-[(1R claim 1 ,2R claim 1 ,4S)-2-methyl-3-methylenebicyclo[2.2.1]hept-5-en-2-yl)]-2-penten-1-ol.5. A perfuming ingredient comprising a compound of formula (I) claim 1 , as defined in .6. A perfuming composition comprising{'claim-ref': {'@idref': 'CLM-00001', 'claim 1'}, 'i) at least one compound of formula (I), as defined in ;'}ii) at least one ingredient selected from the group consisting of a perfumery carrier and a perfumery base; andiii) optionally at least one perfumery adjuvant.7. A perfuming consumer product claim 1 , wherein it comprises at least one compound of formula (I) claim 1 , as defined in .8. A perfuming consumer product according to claim 1 , wherein said product is a perfume claim 1 , a fabric care product claim 1 , a body-care product claim 1 , an air care product or a home care product.9. A perfuming consumer product according to claim 1 , wherein said product is a fine perfume claim 1 , a cologne claim 1 , an after-shave lotion claim 1 , a liquid or solid detergent claim 1 , a fabric softener claim 1 , a fabric refresher claim 1 , an ironing water claim 1 , a paper claim 1 , a bleach claim 1 , a shampoo claim 1 , a coloring preparation claim 1 , a hair spray claim 1 , a vanishing cream claim 1 , a deodorant or antiperspirant claim 1 , a perfumed soap claim 1 ...

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Номер записи: 93
04-10-2018 дата публикации

A green, lily of the valley perfuming ingredient

Номер: US20180282660A1
Автор: Anthony Alexander Birkbeck, Robert Moretti
Принадлежит: FIRMENICH SA

in the form of any one of its stereoisomers or a mixture thereof, and wherein the exocyclic dotted line represents a carbon-carbon single or double bond, and one endocyclic dotted to line represents a carbon-carbon single bond and the other endocyclic dotted line represents a carbon-carbon double bond; and R, R1 and R2 represent, independently from each other, a hydrogen atom or a C1-3 alkyl group; and their use in perfumery to impart odor notes of the green, floral type.

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Номер записи: 94
23-12-2021 дата публикации

Perfuming ingredients with lily of the valley note

Номер: US20210395641A1
Автор: Bernd Hölscher, Eva KIERMASCH, Vijayanand CHANDRASEKARAN
Принадлежит: SYMRISE AG

The present invention primarily relates to the use of 3-(4-isobutyl-2-methyl-cyclohexyl)pro-panal, 3-(4-Isobutyl-6-methyl-cyclohexa-1,5-dien-1-yl)propanal, 3-(4-isobutyl-6-meth-ylene-cyclohexen-1-yl)propanal, or 3-(4-isobutyl-6-methyl-cyclohexen-1-yl)propanal as perfuming ingredients. Moreover, the present invention relates to perfume compositions and perfumed products comprising the before mentioned perfuming ingredients. Still more particularly, the invention relates to a method for producing said perfumed products and a method of imparting and/or increasing i) floral and/or ii) green and/or iii) lily of the valley odor characteristics to perfumed products. This invention also relates to 3-(4-isobutyl-2-methyl-cyclohexyl)propanal, 3-(4-Isobutyl-6-methyl-cyclohexa-1,5-dien-1-yl)propanal, 3-(4-isobutyl-6-methylene-cyclohexen-1-yl)propanal, or 3-(4-isobutyl-6-methyl-cyclohexen-yl)propanal and a process for the preparation of said compounds.

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Номер записи: 95
12-09-2019 дата публикации

Composition having a muguet odor

Номер: US20190276769A1
Автор: Eric Walther, Francesco Santoro, Lionel Saudan
Принадлежит: FIRMENICH SA

A composition of matter comprising a) at least one compound of formula in the form of any one of its isomers or a mixture thereof; wherein R 1 represents a hydrogen atom or a C 1-2 alkyl group; and R represents a group of formula —CH 2 C(Me) 2 OH; with R being, relative to position 1, a meta, a para substituent of the aromatic ring or a mixture thereof; and b) at least one compound of formula in the form of any one of its isomers or a mixture thereof; wherein R 1 and R have the same meaning as defined in formula (I); their uses as perfuming ingredients as well as perfuming composition and consumer products including such a composition of matter and a process to prepare the composition.

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Номер записи: 96
03-09-2020 дата публикации

METHODS AND MATERIALS FOR PRODUCING 7-CARBON MONOMERS

Номер: US20200277634A1
Автор: Botes Adriana L., Chen Changlin, Conradie Alex Van Eck, FOSTER Alexander Brett
Принадлежит: INVISTA North America S.a.r.l.

This document describes biochemical pathways for producing pimeloyl-CoA using a polypeptide having the enzymatic activity of a hydroperoxide lyase to form non-3-enal and 9-oxononanoate from 9-hydroxyperoxyoctadec-10,12-dienoate. Non-3-enal and 9-oxononanoate can be enzymatically converted to pimeloyl-CoA or a salt thereof using one or more polypeptides having the activity of a dehydrogenase, a CoA ligase, an isomerase, a reductase, a thioesterase, a monooxygenase, a hydratase, and/or a thiolase. Pimeloyl-CoA can be enzymatically converted to pimelic acid, 7-aminoheptanoic acid, 7-hydroxyheptanoic acid, heptamethylenediamine, or 1,7-heptanediol, or corresponding salts thereof. This document also describes recombinant microorganisms producing pimeloyl-CoA, as well as pimelic acid, 7-aminoheptanoic acid, 7-hydroxyheptanoic acid, heptamethylenediamine, and 1,7-heptanediol, or corresponding salts thereof. 1. A method of producing azelaic acid in a recombinant microorganism via a fermentation process , said method comprising:enzymatically converting 9-hydroxyperoxyoctadec-10,12-di enoate to non-3-enal and 9-oxononanoate using an exogenous polypeptide having the activity of a hydroperoxide lyase and at least 85% sequence identity to the polypeptide of SEQ ID NO: 13 or SEQ ID NO: 14; andenzymatically converting non-3-enal to azelaic acid using one or more polypeptides comprising at least one polypeptide having the activity of a dodecenoyl-CoA isomerase and at least 85% sequence identity to the polypeptide of SEQ ID NO: 17 or at least one polypeptide having the activity of an enoate reductase and at least 85% sequence identity to the polypeptide of SEQ ID NO: 15 or SEQ ID NO: 16.23-. (canceled)4. The method of claim 1 , wherein enzymatically converting non-3-enal to azelaic acid using one or more polypeptides comprises:{'i': Pseudomonas putida', 'Polaromonas', 'cerevisiae., 'enzymatically converting nonanoic acid to 9-hydroxynonanoic acid using one or more polypeptides ...

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Номер записи: 97
29-10-2015 дата публикации

Improvements In or Relating to Organic Compounds

Номер: US20150307432A1
Автор: Alchenberger Alain, Berbez Chloe, Finn Clare, LELIEVRE Dominique, LOVCHIK Martin Alan, Poignon-Martel Roseline, Romey Gilles
Принадлежит:

5,9-dimethyl-9-hydroxy-decen-4-al, having the formula (I) 2. Compounds according to formula (I) of claim 1 , present in an E/Z isomer ratio of from 8:2 to 2:8.3. A perfume composition comprising a compound according to .4. A perfume composition according to and one or more additional compounds selected from the group consisting of: 2-cyclohexylidene-2-phenylacetonitrile; 4-(octahydro-4 claim 1 ,7-methano-5H-inden-5-ylidene)butanal; 4-Methyl-2-(2-methylpropyl)tetrahydro-2H-pyran-4-ol; and methyl 2-(2-hexyl-3-oxocyclopentyl)acetate.5. A perfume composition according to wherein 2-cyclohexylidene-2-phenylacetonitrile is present in 0.001 to 10 parts by weight per 1 part by weight 5 claim 4 ,9-dimethyl-9-hydroxy-decen-4-al.6. A perfume composition according to wherein 4-methyl-2-(2-methylpropyl)tetrahydro-2H-pyran-4-ol is employed in 0.001 to 20 parts by weight per 1 part by weight 5 claim 4 ,9-dimethyl-9-hydroxy-decen-4-al.7. A perfume composition according to wherein 4-(octahydro-4 claim 4 ,7-methano-5H-inden-5-ylidene)butanal claim 4 , is employed in 0.0001 to 0.5 parts by weight per 1 part by weight 5 claim 4 ,9-dimethyl-9-hydroxy-decen-4-al.8. A perfume composition according to wherein the 5 claim 4 ,9-dimethyl-9-hydroxy-decen-4-al compound is present in said perfume composition in an amount of 1 to 30% by weight based on the total weight of said perfume composition.9. A perfume composition according to comprising at least one additional perfume ingredient.10. A perfume composition according to wherein said at least one additional perfume ingredient si not cyclohexal.11. A process of forming the compound of claim 1 , said process comprising the steps of:I) Reacting hydroxylinalool with ethyl vinyl ether in acid under an inert gas atmosphere at 1 to 100 bar, and a temperature of (−) 10 to 200 degrees centigrade, to form a reaction mixture comprising acetals;II) acidifying the cooled reaction mixture at (−20) to 40 degrees centigrade and atmospheric pressure to ...

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Номер записи: 98
19-10-2017 дата публикации

Process for producing alcohol analogue

Номер: US20170297990A1
Автор: Motomu Kanai, Shigeki Matsunaga
Принадлежит: Takasago International Corp

Provided is a process for producing an optically active hydroxyaldehyde or aminohydroxyaldehyde. The process for producing an optically active hydroxyaldehyde or aminohydroxyaldehyde is characterized by reacting an aldehyde or an imine with a boric acid enol ester in the presence of a copper compound and an optically active bidentate phosphine compound.

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Номер записи: 99
19-10-2017 дата публикации

IMPROVEMENTS IN OR RELATING TO ORGANIC COMPOUNDS

Номер: US20170297992A1
Автор: BAUMGARTNER Corinne, ZELENAY Veronika
Принадлежит:

A fragrance precursor of 3-(4-isobutyl-2-methyl phenyl)propanal, comprising at least an enamine and/or an aminal as reaction product of 3-(4-isobutyl-2-methylphenyl)propanal (compound according to formula (I)) and a primary and/or secondary amine 1. A fragrance precursor of 3-(4-isobutyl-2-methylphenyl)propanal , comprising at least an enamine and/or an aminal as reaction product of 3-(4-isobutyl-2-methylphenyl)propanal and a primary and/or secondary amine.3. A fragrance precursor according to comprising at least (E/Z)-methyl 2-((3-(4-isobutyl-2-methylphenyl)prop-1-en-1-yl)amino)benzoate and/or dimethyl 2 claim 1 ,2′-((3-(4-isobutyl-2-methylphenyl)propane-1 claim 1 ,1-diyl)bis(azanediyl))-dibenzoate.4. A perfume ingredient comprising a fragrance precursor according to .5. A perfume ingredient comprising a fragrance according to claim 4 , wherein the perfume ingredient can release an ingredient with muguet odour characteristics.6. A perfume composition comprising a fragrance precursor according to .7. A perfume composition according to that is substantially free of aryl-substituted propanals that are unsubstituted on the aryl ring at a position ortho to the substituent bearing the aldehyde functionality claim 6 , in particular Lilial™.8. A perfume composition according to further comprising 3-(4-isobutyl-2-methylphenyl)propanal.9. A perfume composition according to comprising one or more additional fragrance ingredients.10. A perfume composition according to which can release an ingredient with muguet odour characteristics.11. A personal care or household care composition comprising at least a fragrance precursor according to .12. A method of imparting a muguet odour characteristic to a perfume composition comprising the step of: adding to the perfume composition a fragrance precursor according to .13. A perfume ingredient comprising a fragrance precursor according to .14. A perfume ingredient comprising a fragrance precursor according to .15. A fragrance precursor ...

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Номер записи: 100