Elektrolyt für einen Elektrolytkondensator und Elektrolytkondensator der dieses Elektrolyt verwendet.

VERFAHREN ZUR HERSTELLUNG VON ALPHAHALOGENIERTEN DICARBONSAEURE SOWIE DEREN VERWENDUNG

PEPTIDYL DERIVATIVES

Compositions and methods

Improvements in or relating to the manufacture of organic carboxylic acids

... 546,866. Dicarboxylic acids. DU PONT DE NEMOURS & CO., E. I. Jan. 31, 1941, No. 1281. Convention date, Jan. 31, 1940. [Class 2 (iii)] Dicarboxylic acids, mainly undecanedioic and dodecanedioic acids are made by oxidizing an ester of 12 hydroxy-stearic acid such as the glyceride (which may be obtained by hydrogenating castor oil) with nitric acid. The operation may be effected at at least 85‹ C. with nitric acid of at least 60 per cent. strength, and an oxidation catalyst may be used. In an example the glyceride is oxidized in the presence of ammonium vanadate with 70 per cent. nitric acid. Other esters of 12 hydroxystearic acid such as the methyl, ethyl, cyclohexyl, benzyl, methoxyethyl and ethylene glycol esters may be oxidized similarly.

Preparation of esters, secondary alcohols and ketones

In an improvement of the process as claimed in Claim (1) of the parent Specification, the olefinic compound is a C5 to C16 secondary branched chain olefin or a C6 to C16 cyclo-olefin bearing an alkyl substituent in any position not adjacent to a double bond, the perfluorocarboxylic acid has 2 to 6 carbon atoms per molecule and the reaction temperature is between 50 DEG and 300 DEG C. 3-methyl-1-butene is mixed with a molecular excess of trifluoroacetic acid, and the mixture maintained at 50-75 DEG C., preferably at 65 DEG C., until a major portion of the methyl butene is combined with the acid to form a mixture of the perfluoroacetic acid esters of 2-methyl-2-butanol and 3-methyl-2-butanol. The esters are saponified to form the free alcohols which are oxidized to isopropylmethyl ketone, by potassium dichromate-sulphuric acid mixture. The tertiary alcohol in the reaction is decomposed on oxidation; alternatively the alcohols may be separated by close fractionation before oxidation. Similarly ...

Acrylamide compounds as histamine H3 receptor ligands

FATTY ACIDS AND THEIR USE IN CONJUGATION TO BIOMOLECULES

Acrylamide compounds as histamine H3 receptor ligands

Acrylamide compounds as histamine H3 receptor ligands

FATTY ACIDS AND THEIR USE IN CONJUGATION TO BIOMOLECULES

FATTY ACIDS AND THEIR USE IN CONJUGATION TO BIOMOLECULES

COSMETIC COMPOSITIONS AND PROCEDURES FOR YOUR USE FOR THE IMPROVEMENT OF THE AESTHETIC APPEARANCE OF THE SKIN

POLYMER DISPERSING AGENT WITH ALTERNATIVE POLYALKYLEN AND GROUPS OF AMBER.

Acrylamide compounds as Histamine H3 receptor ligands

The present invention relates to novel acrylamide compounds of formula (I), and their pharmaceutically acceptable salts and process of their preparation. (The chemical formula should be inserted here.) The compounds of formula (I) are useful in the treatment of various disorders that related to Histamine H ...

Salt of monocyclic pyridine derivative and crystal thereof

Provided is: a salt that can be used as an active pharmaceutical ingredient of a drug, the salt comprising an organic carboxylic acid selected from the group consisting of succinic acid and maleic acid, and a compound represented by formula (I); or a crystal of the salt.

ALKOXYALKYLMERCURIC SALTS

INTERMEDIATES FOR PREPARING 1,4-DIHYDRO-4-OXO-QUINOLINE-3-CARBOXYLIC ACID ESTERS

COMPOSITIONS AND METHODS FOR SIMULTANEOUS INACTIVATION OF ALKALINE PHOSPHATASE AND PEROXIDASE ENZYMES DURING AUTOMATED MULTIPLEX TISSUE STAINING ASSAYS

Disclosed are compositions and methods for inactivating one or more enzymes in a biological sample.

ALIPHATIC MATERIALS AND USES THEREOF IN HEATING AND COOLING APPLICATIONS

Aliphatic materials and their use in passive heating and cooling applications are generally disclosed. In some embodiments, dibasic acids and esters (diesters) thereof and their use in passive heating and cooling applications are disclosed. In some embodiments, C18 dibasic acids and esters thereof are disclosed, including their use in passive heating and cooling applications. In some embodiments, various olefins, including alkenes and olefinic acids and esters, are disclosed, including their use in passive heating and cooling applications.

SUBSTITUTED 4-BIARYLBUTYRIC OR 5-BIARYLPENTANOIC ACIDS AND DERIVATIVES AS MATRIX METALLOPROTEASE INHIBITORS

Inhibitors for matrix metalloproteases, pharmaceutical compositions containing them, and a process for using them to treat a variety of physiological conditions. The compounds of the invention have the generalized formula (T) x A-B-D-E-G, wherein A and B are aryl or heteroaryl rings; each T is a substituent group; x is 0, 1 or 2; the group D represents (a), (b), (c), (d), or (e); the group E represents a two or three carbon chain bearing one to three substituent groups which are independent or are involved in ring formation, possible structures being shown in the text and claims; and the group G represents -PO3H2, -M, (f), (g), or (h), in which M represents -CO2H, -CON(R11)2, or -CO2R12; and R13 represents any of the side chains of the 19 noncyclic naturally occurring amino acids, and include pharmaceutically acceptable salts thereof.

Verfahren zur Herstellung organischer Alkaliverbindungen

Verfahren zur Herstellung von therapeutisch wirksamen Chinolizin-Derivaten

Procédé de préparation d'agents anti-inflammatoires

Verfahren zur Herstellung von therapeutisch wirksamen Chinolizin-Derivaten

Procédé de préparation de dérivés de l'acide a-phényl-propinoique

Procédé de préparation de dérivés de l'acide a-phényl-propionique

Procédé de préparation de nouveaux diacides carboxyliques a,a,a',a'-tétrasubstitués

Verfahren zur Herstellung von Estern von Dicarbonsäuremonochloriden

2 (4 (4 (4,4-DIALKYL-2,6-PIPERIDINDION-1-YL) BUTYL) - 1-PIPERAZINYL) PYRIDINE.

DOUBLE INHIBITORS MEN AND FRES FOR TREATMENT OF KASTRATsIONNO - RESISTANT PROSTATE CANCER AND OSTEOBLASTIChESKIKh BONE METASTASES IN

Useful chemical compositions like detergents and inhibitors of rust

Tétraméthyl-4, 4,5,5 octane-dione-2, 7, its derivatives and process for obtaining of the aforesaid products

Improvements with the halogenous derivatives of the acids dicarboxylic

SALTS ACID POLYCARBOXYLIQUE/AMINE, AQUEOUS SYSTEM THE CONTAINER AND A METHOD FOR INHIBITING THE CORROSION OF METALS

2 (4 (4,4-DIALKYL-2,6-PIPERIDINEDION-1-YL) BUTYL) - 1-PYPERAZINYL) PYRIDINES AND THEIR PHARMACOLOGICAL APPLICATION

히드록시카르복실산, 비-이온성 계면활성제 및 효소를 함유하는 산 액체 압축 세척제

... 본 발명은 액체 세척제의 총 중량을 기준으로 하여, (i) 5 내지 30 중량%, 바람직하게는 10 내지 30 중량%, 특히 15 내지 25 중량%의 2 내지 8개의 탄소 원자를 갖는 적어도 1종의 히드록시카르복실산, (ii) 15 내지 55 중량%, 바람직하게는 20 내지 55 중량%, 특히 35 내지 50 중량%의 적어도 1종의 비-이온성 계면활성제, (iii) 0 내지 20 중량%의 물, 및 (iv) pH < 7의 최적 pH를 갖는 적어도 1종의 효소를 함유하는, < 6.5, 바람직하게는 2 내지 5 범위의 pH 값을 갖는 액체 세척제에 관한 것이다. 상기 액체 세척제는, 특히 탈취제로부터의 성분 및 잔류물 뿐만 아니라, 녹, 장과류, 차 및 레드 와인 잔류물에 기반한 얼룩에 대해 증가된 세정력을 갖는다.

SALT OF MONOCYCLIC PYRIDINE DERIVATIVE AND CRYSTAL THEREOF

produção de ácido carboxílico e co-produtos salinos

Novel fatty acids and their use in conjugation to biomolecules

The invention provides a conjugate comprising a biomolecule linked to a fatty acid via a linker wherein the fatty acid has the following Formulae A1, A2 or A3: wherein R1, R2, R3, R4, Ak, n, m and p are defined herein. The invention also relates to a method for manufacturing the conjugate of the invention such as GDF15 conjugate. and its therapeutic uses such as treatment or prevention of metabolic disorders or diseases, type 2 diabetes mellitus, obesity, pancreatitis, dyslipidemia, alcoholic and nonalcoholic fatty liver disease/steatohepatitis and other progressive liver diseases, insulin resistance, hyperinsulinemia, glucose intolerance, hyperglycemia, metabolic syndrome, hypertension, cardiovascular disease, atherosclerosis, peripheral arterial disease, stroke, heart failure, coronary heart disease, diabetic complications (including but not limited to chronic kidney disease), neuropathy, gastroparesis and other metabolic disorders. The present invention further provides a combination ...

OPTICALLY ACTIVE 'alpha'-SUBSTITUTED CARBOXYLIC ACID DERIVATIVE AND PROCESS FOR PRODUCING THE SAME

An optically active 'alpha'-substituted carboxylic acid derivative represented by general formula (I) wherein R1 represents hydroxy, -C(=CH2)-COOR3 or -CH(CH3)-COOR3; R2 represents methyl or chloro; R3 represents hydrogen or C1-C6 alkyl; n represents an integer of 1 or 2; and the asterisk represents asymmetric carbon, provided when R1 represents hydroxy, R2 represents chloro; and a process for producing the derivative or an enantiomer thereof by using a culture of a microorganism capable of asymmetrically hydrolyzing an ester linkage or a cell thereof which may have been suitably treated. These compounds are useful as the starting material of various liquid crystals and as an intermediate for synthesizing optically active drugs and pesticides.

Deuterated tetramethyl dioic acids, compositions comprising them and uses thereof

This invention relates to deuterated tetramethyl dioic acids, compositions comprising them and uses thereof in the treatment of Metabolic Syndrome and any diseases, disorders or symptoms associated therewith.

СПОСОБ ПОЛУЧЕНИЯ РАСТВОРА СОЛЕЙ ДИКИСЛОТ/ДИАМИНОВ

FIELD: chemistry. ^ SUBSTANCE: invention relates to an improved method of preparing diamine and diacid salt solutions, obtained by mixing diacid and diamine, with weight concentration of the salt ranging from 50% to 80%. The method involves obtaining in a first reactor an aqueous solution of diamine and diacid with molar ratio of diacid to diamine ranging from 1.5 to 5 and with concentration of dissolved particles in water ranging from 40 to 75 wt %, by feeding into the said reactor either an aqueous solution with at least 50 vol. % diamine and diacid with molar ratio ranging from 1.5 to 5, or water making up at least 10% of the total amount of water fed into said reactor, a stream containing diacid, a stream containing diamine and, possibly, a stream of water at temperature T1, where the flow of the fed streams containing acid and the stream containing diamine are is regulated such that temperature of the solution in the reactor constantly remains below the boiling point at operating pressure of the reactor, and molar ratio of diacid to diamine is greater than 1.1, wherein the amount of the fed acid is at least 90% of the total weight of the acid needed to obtain the desired amount of aqueous salt solution; the amount of the fed water is at least 75% of the total weight of the water needed to obtain the desired amount of aqueous salt solution. The aqueous solution obtained in the first reactor is then moved to a second reactor fitted with a condenser and a stream containing diamine is fed into the second reactor to obtain molar ratio of diacid to diamine between 0.9 and 1.1, wherein the temperature of the solution is raised to a value at most equal to boiling point of the solution at operating pressure at least by removing heat released during the reaction between the diamine and diacid and, possibly, the amount of water and/or additional diacid need to obtain a salt solution with the desired concentration and molar ratio of diacid to diamine is used. ^ EFFECT: ...

ЧЕТВЕРТИЧНЫЕ АММОНИЕВЫЕ СОЕДИНЕНИЯ В КАЧЕСТВЕ ДОБАВОК К ТОПЛИВУ ИЛИ СМАЗОЧНЫМ МАТЕРИАЛАМ

FIELD: chemistry. SUBSTANCE: invention relates to an improved method of producing a diesel fuel composition. Method comprises producing quaternary ammonium compound by reaction (a) a tertiary amine of formula R 1 R 2 R 3 N, with (b) epoxide selected from styrene oxide, ethylene oxide, propylene oxide, butylene oxide, epoxy hexane, octene oxide, stilbene oxide, other oxides of alkyls and alkenyls containing from 2 to 50 carbon atoms, glycidyl ethers and glycidyl ethers, in the presence of (c) a monoacid or a mono-ester of a diacid, comprising a hydrocarbyl moiety containing at least 6 carbon atoms; and mixing quaternary ammonium compound with diesel fuel. In tertiary amine R 1 R 2 R 3 N each of R 1 , R 2 and R 3 is independently selected from an alkyl or hydroxyalkyl group containing 1 to 10 carbon atoms; or R 1 is an alkyl group containing 1 to 10 carbon atoms; R 2 represents an alkyl group containing 1 to 10 carbon atoms, and R 3 is a succinimide fragment having formula , where R is a hydrocarbyl group containing 6 to 400 carbon atoms, and L is ethylene, propylene or butylene. Preferably, quaternary ammonium compound has formula where R 1 , R 2 and R 3 are as defined above; R 4 , R 5 , R 6 and R 7 are determined based on epoxide, as defined above; and R includes an alkyl or alkenyl moiety containing at least 6 carbon atoms, and where RCOO - is a residue of said monoacid or a monoether of diacid. Method may involve addition of one or more additional detergents into the diesel composition. Invention also relates to a method of improving operational characteristics of a diesel engine. Proposed method comprises production of diesel fuel composition by said method and combustion of said diesel fuel composition in engine. Diesel engine has a fuel injection system which includes a high pressure fuel injection (HPFI) system in which fuel pressure exceeds 1350 bar (1.35⋅10 8 Pa). Improvement of operational characteristics occurs as a result of counteraction to deposits in ...

СПОСОБ КАТАЛИТИЧЕСКОГО ОКИСЛЕНИЯ ЛИГНИТА ПРИ АТМОСФЕРНОМ ДАВЛЕНИИ С ИСПОЛЬЗОВАНИЕМ КИСЛОРОДА В КАЧЕСТВЕ ОКИСЛИТЕЛЯ

FIELD: technological processes. SUBSTANCE: invention relates to a method for catalytic oxidation of lignite using oxygen as an oxidant at atmospheric pressure. Method is used for soft oxidation of lignite using oxygen as an oxidant under action of a nitroxyl radical as a catalyst and a salt or a metal oxide as a cocatalyst. Process consists of the following stages: grinding lignite to 200 mesh or less, drying the pulverized-coal sample at temperature of 80 °C in vacuum for 10 hours at weight of 0.5 g of treated coal, successive addition of 10 ml of acetic acid, 0.5 mM of catalyst and 0.15–0.25 mM of cocatalyst into flask with round bottom, connection of T-joint with upper hole of condenser tube, three-fold replacement of oxygen in vacuum so that bulb with round bottom is filled with oxygen, maintaining oxygen pressure at level of 0.1 MPa, reaction at temperature of 80 °C to 120 °C for 4 to 12 hours; filtration after termination of reaction; decompressing the filtrate to remove acetic acid, adding a small amount of ethyl acetate for dissolution, and then adding excess CH 2 N 2 /ester solution for etherification at room temperature for 10 hours, use of filter paper 0.45 mcm for filtration and analysis of esterified product using gas chromatograph-mass spectrometer. EFFECT: technical result consists in using oxygen as an oxidiser, having low cost, non-toxic, thereby ensuring environmental protection and mild conditions. 3 cl, 1 dwg, 6 ex РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (51) МПК B01J 31/04 C07C 51/21 C07C 55/02 C07C 55/14 C07C 57/03 C07C 59/01 ФЕДЕРАЛЬНАЯ СЛУЖБА C07C 59/08 ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ C07C 63/06 C07C 65/21 (12) (11) (13) 2 700 265 C1 (2006.01) (2006.01) (2006.01) (2006.01) (2006.01) (2006.01) (2006.01) (2006.01) (2006.01) ОПИСАНИЕ ИЗОБРЕТЕНИЯ К ПАТЕНТУ (52) СПК B01J 31/04 (2019.05); C07C 51/21 (2019.05); C07C 55/02 (2019.05); C07C 55/14 (2019.05); C07C 59/01 (2019.05); C07C 59/08 (2019.05); C07C 63/06 (2019.05); C07C 65/21 (2019.05) 2018145388, 07.12. ...

VERWENDUNG VON ALKALI- ODER AMINSALZEN EINES GEMISCHES AUS 2- UND 3-ALKYLADIPINSAEUREN ALS KORROSIONSINHIBITOR

Peptidyl derivatives

PCT No. PCT/GB91/02143 Sec. 371 Date Jul. 29, 1992 Sec. 102(e) Date Jul. 29, 1992 PCT Filed Dec. 3, 1991 PCT Pub. No. WO90/05719 PCT Pub. Date May 31, 1990.A compound of formula (I): (* CHEMICAL STRUCTURE *) (I) wherein R represents a -CONHOH, carboxyl (-CO2H) or esterified carboxyl group; X represents an amino (-NH2), or substituted amino, hydroxyl or substituted hydroxyl group; and their use as metalloproteinase inhibitors.

Piperazine derivatives

... 1-?4-(4,4-Dialkyl-2,6-piperidinedion-1-yl)butyl!piperazines with 2-2-(3-cyano)pyridyl substituents in the 4- position have been synthesized and demonstrate useful psychotropic properties.

... 1296702 ,,1,1 - Tetrahydrocarbylalkandioic acid or ester BRITISH PETROLEUM CO Ltd 1 June 1970 [30 June 1969] 32891/69 Heading C2C ,,1,1 - Tetrahydrocarbylalkandioic acids or esters are prepared by reacting a diene of formula CH 2 =CH-(CH 2 ) x -CH x -=CH 2 (x is 0, 1, 2 or 5 to 10) with a monocarboxylic acid or ester of formula where R is hydrogen, a C 1-12 alkyl or cycloalkyl group or a C 6-12 aryl group and R1 and R2 which may be the same or different are C 1-12 alkyl or cycloalkyl groups or C 6-12 aryl groups, in the presence of a free-radical generating initiator. Organic peroxides and azo and diazo compounds such as di-t-butyl peroxide, azobisisobutyronitrile, benzoyl peroxide and diisopropyl peroxycarbonate, reducible transition metal compounds, e.g. mangones, cobalt, iron, cesium, and rhenium, acid anhydride and/or monocarboxylic acids or esters are used as initiators. Examples describe the preparation of 2,2,9,9- tetramethyl ...

VERFAHREN ZUR HERSTELLUNG VON NEUEN 2-(4-((4,4 -DIALKYL-2,6-PIPERIDIN-DION-1-YL)-BUTYL)-1-PIPE - AZINYL)-PYRIDINEN UND VON DEREN PHARMAZEUTISCH ZULAESSIGEN SAEUREADDITIONSSALZEN

PEPTIDYLDERIVATE.

PEPTIDYL DERIVATIVES

Carboxylic acids and derivatives thereof and pharmaceutical compositions contai ning them

INTERMEDIATES FOR PREPARING 1,4-DIHYDRO-4-OXO-QUINOLINE-3-CARBOXYLIC ACID ESTERS

NOVEL POLYMERIC DISPERSANTS HAVING ALTERNATING POLYALKYLENE AND SUCCINIC GROUPS

Salt of monocyclic pyridine derivative and crystal thereof

Provided is: a salt that can be used as an active pharmaceutical ingredient of a drug, the salt comprising an organic carboxylic acid selected from the group consisting of succinic acid and maleic acid, and a compound represented by formula (I); or a crystal of the salt.

Salts or co-crystals of 3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol

Abstract: The invention relates to a salt or cocrystal of 3-(3-dimethylamino-1-ethyl-2-methyl-propyl) phenol (component a) and at least one acid component (b1) or at least one acid component (b2), wherein the salt or cocrystal of component (a) and component (b2) is present in crystalline and/or amorphous form, a medicament comprising said salt or cocrystal as well as said salt or cocrystal for use in the treatment of pain.

POLYMERIC DISPERSANTS HAVING ALTERNATING POLYALKYLENE AND SUCCINIC GROUPS

Novel copolymers of unsaturated acidic reactants and high molecular weight olefins wherein at least 20 percent of the total high molecular weight olefin comprises the alkylvinylidene isomer are useful as dispersants in lubricating oils and fuels and also may be used to prepare polysuccinimides and other post-treated additives useful in lubricating oils and fuels.

2-[4-[(4,4,-DIALKYL-2,6,-PIPERIDINEDION-1- YL)BUTYL]-1-PIPERAZINYL] PYRIDINES

POLYMERS PREPARED FROM MEVALONOLACTONE AND DERIVATIVES

Described herein polymer precursor compounds (aka polymer building blocks) of derived from biobased compounds, and specifically biobased mevalonolactone and its related derivatives. Through oxidation these biobased precursors can be reacted to yield building blocks for (unsaturated-) polyesters, polyester polyols and polyamides, as well as precursors for glycidyl esters and omega-alkenyl esters. Through reduction, these biobased precursors can be reacted to yield building blocks for (unsaturated-) polyesters, polyester polyols, polycarbonates, as well as precursors for glycidyl ethers and omega-alkenyl ethers. Through nucleophilic ring opening and/or amidation, these biobased precursors can be reacted to yield building blocks for polyester polyols, chain-extender for polyurethanes, or polyester-amides.

POLYMERS PREPARED FROM MEVALONOLACTONE AND DERIVATIVES

Described herein polymer precursor compounds (aka polymer building blocks) of derived from biobased compounds, and specifically biobased mevalonolactone and its related derivatives. Through oxidation these biobased precursors can be reacted to yield building blocks for (unsaturated-) polyesters, polyester polyols and polyamides, as well as precursors for glycidyl esters and omega-alkenyl esters. Through reduction, these biobased precursors can be reacted to yield building blocks for (unsaturated-) polyesters, polyester polyols, polycarbonates, as well as precursors for glycidyl ethers and omega-alkenyl ethers. Through nucleophilic ring opening and/or amidation, these biobased precursors can be reacted to yield building blocks for polyester polyols, chain-extender for polyurethanes, or polyester-amides.

COMPLEXES OF 1-METHYLCYCLOPROPENE WITH METAL COORDINATION POLYMER NETWORKS

Disclosed are adsorption complexes that include 1-methylcyclopropene (1-MCP) and a metal coordination polymer network (MCPN), wherein the MCPN is a porous material, and the 1- MCP is adsorbed into the MCPN. Also disclosed are kits for containing 1-MCP that include the adsorption complex in a 1-MCP-impermeable package. Also disclosed are methods of releasing 1- methylcyclopropene (1-MCP) from the kit that include the application of aqueous fluids, heat, and/or pressure.

PROCESS FOR THE SEPARATION, RECOVERY AND PURIFICATION OF DICARBOXYLIC ACIDS

A process for removing, isolating and purifying dicarboxylic acid from fermentation broths, which comprises the following steps: f) removal of the biomass and any solids present from the fermentation broth in two successive stages, g) removal of the dicarboxylic acid solution from the biomass-free fermentation broth by simulated moving bed (SMB) chromatography, h) fine purification of the dicarboxylic acid solution, i) multistage evaporative concentration and crystallization, j) separation and drying of the crystals.

FATTY ACIDS AND THEIR APPLICATION FOR CONJUGATION WITH NATOTUBES

ACRYLAMIDE COMPOUNDS AS LIGANDS H-HISTAMINE RECEPTOR

Diamides substituted drifting of acids alkylene-dicarboxyliques and their methods of preparation

Improvements with the method of preparation of esters of acids alpha-méthylènecarboxyliques

2-(4-(4,4-DIALKYL-2,6-PIPERIDINEDION-1-YL) BUTYL)-1-PYPERAZINYL) PYRIDINES ET LEUR APPLICATION PHARMACOLOGIQUE

A TITRE DE PRODUITS INDUSTRIELS NOUVEAUX, UN COMPOSE APPARTENANT AU GROUPE DE COMPOSES PRESENTANT LA FORMULE I AINSI QUE LES SELS D'ADDITION D'ACIDES ACCEPTABLES DU POINT DE VUE PHARMACEUTIQUE ET NON TOXIQUES DE FORMULE: (CF DESSIN DANS BOPI) DANS LAQUELLE: R ET R INDEPENDAMMENT L'UN DE L'AUTRE, CONSISTENT EN DES GROUPES ALKYLES COMPRENANT 1 A 4 ATOMES DE CARBONE; Z ETANT UN ATOME D'HYDROGENE, D'HALOGENE OU PSEUDOHALOGENE, DE PREFERENCE UN ATOME DE FLUOR, DE CHLORE OU GROUPE TRIFLUOROMETHYLE.

DUAL INHIBITORS OF MET AND VEGF FOR THE TREATMENT OF CASTRATION- RESISTANT PROSTATE CANCER AND OSTEOBLASTIC BONE METASTASES

Method of treating cancer

This invention is directed to the treatment of cancer, particularly castration-resistant prostate cancer and osteoblastic bone metastases, with a dual inhibitor of MET and VEGF.

SERUM TRIGLYCERIDE-LOWERING COMPOSITIONS

FERMENTATION PRODUCTION OF LONG CHAIN 'alpha','omega'-DICARBOXYLIC ACIDS FROM ALKANES BY USE OF A MICROORGANISM

Provided is a method for producing long chain 'alpha','omega'-dicarboxylic acids by fermentation from long chain alkanes and recovering the produced dicarboxylic acids. Also provided is a novel microorganism useful for carrying out the method of the invention.

Salts of an epidermal growth factor receptor kinase inhibitor

The present invention provides a salt form and compositions thereof, which are useful as an inhibitor of EGFR kinases and which exhibits desirable characteristics for the same.

CONTINUOUS PROCESS OF OXIDATIVE CLEAVAGE OF VEGETABLE OILS

A continuous process for the oxidative cleavage of vegetable oils containing triglycerides of unsaturated carboxylic acids, to obtain saturated carboxylic acids, comprising feeding to a first continuous reactor a vegetable oil, an oxidizing compound and catalyst capable of catalyzing the oxidation reaction of the olefinic double bond to obtain an intermediate compound containing vicinal diols: feeding to a second continuous reactor said intermediate compound, a compound containing oxygen and a catalyst capable of catalyzing the oxidation reaction of the vicinal diols to carboxylic groups, to obtain saturated monocarboxylic acids (i) and triglycerides containing saturated carboxylic acids with more than one acid function (ii); separating the saturated monocarboxylic acids (i) from the triglycerides (ii); hydrolyzing in a third reactor the triglycerides (ii) to obtain glycerol and saturated carboxylic acids with more than one acid function; and purifying said saturated carboxylic acids by fractioned crystallization by means of wash column (melt crystallization). 1. A continuous process for the oxidative cleavage of vegetable oils containing triglycerides of unsaturated carboxylic acids , for obtaining saturated carboxylic acids , which comprises the steps of:a) feeding to a first continuous reactor at least a vegetable oil and an oxidizing compound in the presence of a catalyst capable of catalyzing the oxidation reaction of the olefinic double bond to obtain an intermediate compound containing vicinal diols;b) feeding to a second continuous reactor said intermediate compound, oxygen or a compound containing oxygen, and a catalyst capable of catalyzing the oxidation reaction of said diols to carboxylic groups, to obtain saturated monocarboxylic acids (i) and triglycerides containing saturated monocarboxylic acids with more than one acid function (ii);c) transferring the product of step b) to an apparatus suitable to separate the saturated monocarboxylic acids (i) from ...

Aliphatic Materials and Uses Thereof in Heating and Cooling Applications

Aliphatic materials and their use in passive heating and cooling applications are generally disclosed. In some embodiments, dibasic acids and esters (diesters) thereof and their use in passive heating and cooling applications are disclosed. In some embodiments, Cdibasic acids and esters thereof are disclosed, including their use in passive heating and cooling applications. In some embodiments, various olefins, including alkenes and olefinic acids and esters, are disclosed, including their use in passive heating and cooling applications. 25-. (canceled)6. The method of claim 1 , wherein Xis —(CH)—.7. (canceled)8. (canceled)9. The method of claim 1 , wherein Ris an unbranched Calkyl claim 1 , which is optionally substituted one or more times by —OH.10. The method of claim 9 , wherein Ris methyl claim 9 , ethyl claim 9 , propyl claim 9 , butyl claim 9 , pentyl claim 9 , hexyl claim 9 , heptyl claim 9 , or octyl.11. The method of claim 9 , wherein Ris —CH—OH claim 9 , —CH—CH—OH claim 9 , —CH(—CH)—CH—OH claim 9 , or —CH—CH(—OH)—CH.12. The method of claim 1 , wherein Ris a branched Calkyl claim 1 , which is optionally substituted one or more times by —OH.13. The method of claim 12 , wherein Ris a branched Calkyl that comprises branching at the α-position.14. The method of claim 13 , wherein Ris isopropyl claim 13 , sec-butyl claim 13 , or tert-butyl.15. The method of claim 12 , wherein Ris a branched Calkyl that comprises branching at the β-position.16. The method of claim 15 , wherein Ris isobutyl or 2-ethylhexyl.17. The method of claim 12 , wherein Ris a branched Calkyl that comprises branching at the ψ-position.18. The method of claim 17 , wherein Ris isobutyl claim 17 , isoamyl claim 17 , neopentyl claim 17 , or 3 claim 17 ,5 claim 17 ,5-trimethylhexyl.1924-. (canceled)25. The method of claim 9 , wherein Ris an unbranched Calkyl claim 9 , which is optionally substituted one or more times by —OH.26. The method of claim 25 , wherein Ris methyl claim 25 , ethyl claim 25 ...

СОЛИ ИНГИБИТОРА КИНАЗЫ РЕЦЕПТОРА ЭПИДЕРМАЛЬНОГО ФАКТОРА РОСТА

FIELD: chemistry.SUBSTANCE: invention relates to novel salt forms of a compound of formula 2 or a hydrate or solvate thereof. Compounds have selective inhibition properties of at least one epidermal growth factor receptor (EGFR) mutant compared to wild-type EGFR (EGFR WT). Mutant of epidermal growth factor receptor kinase (EGFR) receptors is an activating mutant, a deletion mutant, a mutation with a point mutation or a mutant selected from T790M, deIE746-A750, L858R and G719S. Salts of compound 2 are described by general formulawhere n is 1 or 2; and X is hydrobromic acid, benzenesulphonic acid, camphorsulphonic acid, 1,2-ethane disulphonic acid, hydrochloric acid, maleic acid, methanesulphonic acid, naphthalene-2-sulphonic acid, 1,5-naphthalene disulphonic acid, oxalic acid, 4-toluenesulphonic acid or 2,4,6-trihydroxybenzoic acid. Also described are crystal forms of salts characterized by data of X-ray powder diffraction pattern.EFFECT: compounds can be used in treating tumorous diseases, such as non-small-cell lung cancer.31 cl, 87 dwg, 21 tbl, 16 ex РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 2 711 077 C2 (51) МПК C07D 403/12 (2006.01) A61K 31/506 (2006.01) A61P 35/00 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ОПИСАНИЕ ИЗОБРЕТЕНИЯ К ПАТЕНТУ (52) СПК C07D 403/12 (2013.01); A61K 31/506 (2013.01); C07B 2200/13 (2013.01) (21)(22) Заявка: 2014136893, 13.03.2013 (24) Дата начала отсчета срока действия патента: Дата регистрации: 15.01.2020 (73) Патентообладатель(и): Селджен КАР ЛЛС (BM) 15.03.2012 US 61/611,400 (43) Дата публикации заявки: 10.05.2016 Бюл. № 13 (45) Опубликовано: 15.01.2020 Бюл. № 2 (85) Дата начала рассмотрения заявки PCT на национальной фазе: 15.10.2014 2 7 1 1 0 7 7 US 2013/030996 (13.03.2013) C 2 C 2 (86) Заявка PCT: (56) Список документов, цитированных в отчете о поиске: WO 2010129053 A2, 11.11.2010. OGISO H. et al. Crystal structure of the complex of human epidermal growth factor and receptor extracellular domains CELL, CELL ...

КРИСТАЛЛЫ СОЛИ

Настоящее изобретение относится к (6aR,9aS)-5,6a,7,8,9,9a-гексагидро-5-метил-3-(фениламино)-2-((4-(6-фторпиридин-2-ил)фенил)метил)-циклопента[4,5]имидазо[1,2-a]пиразоло[4,3-e]пиримидина-4(2H)-ону в форме кислотно-аддитивной соли монофосфата, в частности к кристаллам такой соли. Изобретение также относится к композиции, содержащей их, и способу получения кристаллов такой соли и использованию такой соли. Технический результат – получение стабильной кислотно-аддитивной соли, подходящей для изготовления галеновых препаратов. 5 н. и 21 з.п. ф-лы, 5 ил., 7 табл., 7 пр.

Polycarboxylic fatty acids prodn - using thin layer process

Fatty acids with >1 carboxyl gp. are prepd. by reaction of homogeneous mixts. of OH-gp. contg. fatty acids and polycarboxylic acids or their derivs. in a thin layer. Normally cyclic or heterocyclic acids or their derivs. are used. e.g. itaconic acid. and phthalic acid anhydride.

Anti-Inflammatory Agents

... 971,700. Araliphatic acids, esters, alcohols and amines. BOOTS PURE DRUG CO. Ltd. Jan. 12, 1962 [Feb. 2, 1961], No. 3999/61. Heading C2C. [Also in Division A5] The invention comprises compounds of general formula which are (A) acids, and their inorganic and organic salts, wherein X is COOH, R1 is isobutyl, s-butyl, pentyl (other than n-pentyl), 1-methylcyclohexyl, 1-ethylcyclohexyl or cycloheptyl, and R2 is hydrogen or methyl, and if R2 is methyl R1 may also be ethyl, n-propyl, t-butyl or cyclohexyl, (B) alcohols wherein X is CH 2 OH, R1 is isobutyl, s-butyl, pentyl (other than n-pentyl or t-pentyl); 1-methylcyclohexyl, 1-ethylcyclohexyl or cycloheptyl, and R2 is hydrogen or methyl, and, if R2 is methyl, R1 may also be n-propyl, iso-propyl, t-butyl or t-pentyl, (C) esters wherein X is COOR3, R1 is isobutyl, pentyl (other than n-pentyl or t-pentyl), cyclohexyl, 1-methylcyclohexyl, 1-ethylcyclohexyl ...

Conductive ink

Stable water-in-oil emulsion

Stable water-in-oil emulsions suitable for use as lubricants and hydraulic fluids comprise 1-80 parts (by weight) of water and 20-99 parts of oil, and 0.2-10 parts per 100 parts of emulsion of an ester derived from a substantially saturated (i.e. no more than 5% unsaturated bonds) hydrocarbon-substituted succinic acid having at 50 aliphatic carbon atoms in the substituent and a non-acylated polyhydric alcohol which is free from amino groups, but which may contain one or more ether linkages. Typical esters are prepared by reacting polyisobutylene-substituted succinic anhydride with polypropylene glycol, sorbitol or 1,4-butane diol, others being exemplified. The oil may be a mineral oil, or a mixture of different oils such as mineral oil, vegetable oil, animal oil, silicon-containing oils, polyolefin oils, and polyester oils. Many other additives may optionally be present, these being as described in the parent Specification.ALSO:Sorbitol is reacted with propylene oxide in the equivalents ...

New alpha,alpha,alpha',alpha'-Tetrasubstituted Carboxylic Diacids and process for their preparation

... 1,159,503. Di-carboxylic acids. SOC. D'ELECTRO-CHIMIE D'ELECTROMETALLURGIE ET DES ACIERIES ELECTRIQUES D'UGINE. 2 Nov., 1966 [5 Nov., 1965; 3 May, 1966], No. 49160/66. Heading C2C. Diacids of formulµ in which R and R1 represent an alkyl group (1-5 C), an arylaliphatic group, or an aromatic group, or in which R and R1 are joined by one or two carbon-carbon bonds or carbon-heteroatom bonds, e.g. carbon-oxygen or carbonnitrogen to form a divalent radical with e.g. a 2-11 C chain, which may be saturated or unsaturated, and may be substituted, e.g. by alkyl or aryl groups or other functions are prepared by reacting, preferably in an anhydrous medium, a diester of 2-methylene 1,3-propanediol with either a hydride, amide or alcoholate of an alkali metal, or a Grignard reagent, neutralizing with a strong acid and separating the product. The unsaturated diacid may be reduced by catalytic hydrogenation to the diacid (II). Examples describe the preparation of 4-methylene 2,2,6,6- ...

Improvements in or relating to cyclic anhydrides

... 1,127,777. Substituted cyclic anhydrides. GENERAL ANILINE & FILM CORP. 8 Oct., 1965 [9 Oct., 1964], No. 42878/65. Heading C2C. Alkylated cyclic anhydrides are prepared by heating from 0À01-10 moles of an -olefin of 2-100 C atoms, or a chloro-fluoro--olefin or fluoro--olefin of 2 C atoms with one mole of a cyclic anhydride of formula wherein R represents a single bond joining the two CH 2 groups, or is an -O-, or -CH 2 - group, at 100-200‹ C. for 3-60 hours in the presence of 0À02-0À3 moles of an organic peroxide per mole of -olefin used, using elevated pressure with the 2-6 C olefins or the haloolefins. The products are claimed per se when they leave the formula wherein R is -O- or -CH 2 -, and R1 is the residue of the added olefin.

Compositions and methods

PROCEDURE FOR the PRODUCTION OF NEW ONE 2 (4 ((4.4 - DIALKYL-2,6-PIPERIDIN-DION-1-YL) - BUTYL) - 1-PIPE - AZINYL) - PYRIDINEN AND OF THEIR PHARMACEUTICAL PERMISSIBLE SAEUREADDITIONSSALZEN

HEMMER THE KOLLAGENASE SAEUGETIERE.

SUBSTITUTED 4-BIARYLBUTYR-ODER 5 - BIARYLPENTASÄUREN AND DERIVATIVES AS MATRIX METALLOPROTEASE INHIBITORS

PROCEDURE FOR the PRODUCTION OF NEW ONE 2 (4 ((4.4 - DIALKYL-2,6-PIPERIDIN-DION-1-YL) - BUTYL) - 1-PIPE - AZINYL) - PYRIDINEN AND OF THEIR PHARMACEUTICAL PERMISSIBLE ACID ADDITION SALTS

-1-PIPERAZINYL PYRIMIDINES

Process for removing, isolating and purifying dicarboxylic acids

A process for removing, isolating and purifying dicarboxylic acid from fermentation broths, which comprises the following steps: f) removal of the biomass and any solids present from the fermentation broth in two successive stages, g) removal of the dicarboxylic acid solution from the biomass-free fermentation broth by simulated moving bed (SMB) chromatography, h) fine purification of the dicarboxylic acid solution, i) multistage evaporative concentration and crystallization, j) separation and drying of the crystals.

Salts or co-crystals of 3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol

Abstract Salts or co-crystals of 3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-pheno The invention relates to a salt or cocrystal of 3-(3-dimethylamino-1-ethyl-2-methyl-propyl) phenol (component a) and at least one acid component (b1) or at least one acid component (b2), wherein the salt or cocrystal of component (a) and component (b2) is present in crystalline and/or amorphous form, a medicament comprising said salt or cocrystal as well as said salt or cocrystal for use in the treatment of pain.

PRODUCTION OF SUBSTITUTED-BUTANEDIPEROXOIC ACIDS

PRODUCTION OF SUBSTITUTED-BUTANEDIPEROXOIC ACIDS ABSTRACT Substituted-butanediperoxoic acid is produced by reacting substituted succinic anhydride with a mixture of concentrated sulfuric acid and hydrogen peroxide. The succinic anhydride preferably has the formula wherein R is alkyl of 6 to 18 carbon atoms or phenyl. The substituted-butanediperoxoic acids are particularly useful as bleaching agents.

DUAL INHIBITORS OF MET AND VEGF FOR THE TREATMENT OF CASTRATION-RESISTANT PROSTATE CANCER AND OSTEOBLASTIC BONE METASTASES

This invention is directed to the treatment of cancer, particularly castration-resistant prostate cancer and osteoblastic bone metastases, with a dual inhibitor of MET and VEGF.

Production of carboxylic acid and salt co-products

This invention provide processes for producing carboxylic acid product, along with useful salts. The carboxylic acid product that is produced according to this invention is preferably a C 2 -C 12 carboxylic acid. Among the salts produced in the process of the invention are ammonium salts.

Purification of succinic acid from the fermentation broth containing ammonium succinate

This present invention relates to the processes for the purification of succinic acid from a fermentation broth containing ammonium succinate. The process for the purification of succinic acid described in this invention involves the use of ion exchange resins for splitting the ammonium succinate in the fermentation broth. During the passage of the fermentation broth through a cationic ion exchange resin, the ammonium succinate is split into ammonium cation and the succinate anion. The proton on the resin surface is exchanged for the ammonium ions and the succinate anion is reduced to succinic acid with the protons released from the ion exchange resin. The bound ammonium is released from the resin with the addition of a strong acid such as sulfuric acid and thereby the ion exchange resin is regenerated for subsequent use. The ammonium sulfate by-product resulting from the regeneration step of this process can be used as a source of fertilizer. This process for the separation of succinic acid from the fermentation broth containing ammonium succinate can also be carried out with an anionic ion exchange resin wherein the succinate anion is retained on the surface of the ion exchange resin and subsequently released from the ion exchange resin during the regeneration step.

Process for removing, isolating and purifying dicarboxylic acids

A process for removing, isolating and purifying dicarboxylic acid from fermentation broths, which includes the following steps: 1) removal of the biomass and any solids present from the fermentation broth in two successive stages, 2) removal of the dicarboxylic acid solution from the biomass-free fermentation broth by simulated moving bed (SMB) chromatography, 3) fine purification of the dicarboxylic acid solution, 4) multistage evaporative concentration and crystallization, and 5) separation and drying of the crystals.

Method of Treating Cancer

This invention is directed to the treatment of cancer, particularly castration-resistant prostate cancer and osteoblastic bone metastases, with a dual inhibitor of MET and VEGF. 2. (canceled)3. (canceled)4. (canceled)7. The compound of claim 6 , which is N-(4-{[6 claim 6 ,7-bis(methyloxy)quinolin-4-yl]oxy}phenyl)-N′-(4-fluorophenyl)cyclopropane-1 claim 6 ,1-dicarboxamide.8. The method of claim 1 , wherein the compound of Formula (I) claim 1 , Formula I(a) and Compound 1 is the (L)- or (D)-malate salt.9. The method of claim 1 , wherein the compound of Formula (I) is in the crystalline N-1 form of the (L) malate salt and/or the (D) malate salt.10. The method of wherein the compound of Formula I claim 1 , I(a) claim 1 , or Compound 1 claim 1 , or a pharmaceutically acceptable salt thereof claim 1 , is administered as a pharmaceutical composition additionally comprising a pharmaceutically acceptable carrier claim 1 , excipient claim 1 , or diluent.11. A method for treating osteoblastic bone metastases associated with CRPC claim 1 , comprising administering a pharmaceutical composition comprising Compound of Formula I or the malate salt of Compound of Formula I or another pharmaceutically acceptable salt of Compound of Formula I claim 1 , to a patient in need of such treatment.12. A method for ameliorating abnormal deposition of unstructured bone accompanied by increased skeletal fractures claim 1 , spinal cord compression claim 1 , and severe bone pain of osteoblastic bone metastases claim 1 , comprising administering to a patient in need of such treatment a therapeutically effective amount of a compound of Formula I in any of the embodiments disclosed herein.13. A method for reducing or stabilizing metastatic bone lesions associated with CRPC claim 1 , comprising administering a therapeutically effective amount of a pharmaceutical composition comprising Compound of Formula I or the malate salt of Compound of Formula I or another pharmaceutically acceptable salt of ...

NOVEL FATTY ACIDS AND THEIR USE IN CONJUGATION TO BIOMOLECULES

The invention provides a conjugate comprising a biomolecule linked to a fatty acid via a linker wherein the fatty acid has the following Formulae A1, A2 or A3: 124-. (canceled)26. The compound according to claim 25 , or an amide claim 25 , ester or pharmaceutically acceptable salt thereof claim 25 , wherein the compound is of Formula A1 wherein at least one of Rand Ris COH.29. A peptide selected from MH(199-308)hGDF15 (SEQ ID NO: 4) claim 25 , MHA(200-308)hGDF15 (SEQ ID NO: 6) claim 25 , AHA(200-308)hGDF15 (SEQ ID NO: 7) claim 25 , AH(199-308)hGDF15 (SEQ ID NO: 5) claim 25 , MHHHHHHM-hGDF15 (SEQ ID NO: 2) and MHHHHHH-hGDF15 (SEQ ID NO: 1). This application is a divisional application of U.S. application Ser. No. 15/985,060, filed on May 21, 2018, now allowed, which is a divisional of Ser. No. 14/738,272, filed on Jun. 12, 2015, now U.S. Pat. No. 10,588,980, which claims priority to, and the benefit under 35 U.S.C. § 119(e) of U.S. Provisional Application No. 62/107,016, filed Jan. 23, 2015, U.S. Provisional Application No. 62/082,327, filed on Nov. 20, 2014, and U.S. Provisional Application No. 62/015,862 filed on Jun. 23, 2014, the entire contents of each of which are incorporated herein by reference in their entireties.The contents of the text file named “PAT056274-US-DIV02_Sequence Listing_ST25.txt,” which was created on May 26, 2020 and is 33 KB in size, are hereby incorporated by reference in their entireties.The present invention relates to novel conjugates of GDF15 which have improved half-life and duration of action, method of making them and using them. The invention further relates to novel fatty acids and their use in extending the half-life of biomolecules via conjugation.Peptides and proteins are widely used in medical practice, and since they can be produced by recombinant DNA technology it can be expected that their importance will increase also in the years to come. The number of known endogenous peptides and proteins with interesting biological ...

SALTS OF AN EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR

The present invention provides a salt form and compositions thereof, which are useful as an inhibitor of EGFR kinases and which exhibits desirable characteristics for the same. 132-. (canceled)34. The compound of claim 33 , wherein:X is benzenesulfonic acid;n is 2; andthe compound is characterized by one or more peaks in a X-ray powder diffraction pattern selected from those at about 5.62, about 17.41, about 18.90, about 19.07 and about 19.52 degrees 2-theta.35. The compound of claim 34 , wherein the compound is characterized by substantially all of the peaks in a X-ray powder diffraction pattern selected from those at about 5.62 claim 34 , about 7.89 claim 34 , about 11.23 claim 34 , about 12.64 claim 34 , about 17.41 claim 34 , about 18.90 claim 34 , about 19.07 claim 34 , about 19.52 claim 34 , about 22.63 claim 34 , about 23.17 claim 34 , about 25.28 and about 28.92 degrees 2-theta.36. The compound of claim 33 , wherein:X is hydrochloric acid;n is 2; andthe compound is characterized by one or more peaks in a X-ray powder diffraction pattern selected from those at about 17.58, about 23.32, about 25.53 and about 28.37 degrees 2-theta.37. The compound of claim 36 , wherein the compound is characterized by substantially all of the peaks in a X-ray powder diffraction pattern selected from those at about 17.58 claim 36 , about 20.13 claim 36 , about 22.14 claim 36 , about 23.32 claim 36 , about 25.53 claim 36 , about 26.60 claim 36 , about 27.80 and about 28.37 degrees 2-theta.38. The compound of claim 33 , wherein:X is maleic acid;n is 1; andthe compound is characterized by one or more peaks in a X-ray powder diffraction pattern selected from those at about 8.38, about 23.59 and about 23.80 degrees 2-theta.39. The compound of claim 38 , wherein the compound is characterized by substantially all of the peaks in a X-ray powder diffraction pattern selected from those at about 8.38 claim 38 , about 13.74 claim 38 , about 16.35 claim 38 , about 16.54 claim 38 , about 20. ...

CONDUCTIVE INK

A method of forming transparent electrodes using printable conductive ink containing conductive materials dispersed in a viscous liquid which upon printing and thermal treatment will vaporise fully leaving behind the conductive material only. The viscous liquid acts as a medium by which conductive material dispersions are made processable for use in various printing techniques, allowing conductive patterns to be printed onto substrates (e.g. plastics, glass, metals, ceramics). 1. A method of producing a printable conductive ink , comprising:forming a mixture of a first composition, comprising at least one amine;a second composition, comprising at least one carboxylic acid; anda conductive material.2. The method according to claim 1 , wherein the conductive material is mixed with the first composition prior to mixing of the second composition.3. The method according to claim 1 , wherein the conductive material is mixed with the second composition prior to mixing of the first composition.4. The method according to claim 1 , wherein the conductive material is mixed with the first and second compositions after mixing of the first and second compositions.5. The method according to claim 1 , wherein the at least one amine is a primary amine or carbon-bridged diamine.6. The method according to claim 1 , wherein the at least one amine is a primary amine having a total carbon count of 1 claim 1 , 2 claim 1 , 3 claim 1 , 4 claim 1 , or 5.7. The method according to claim 1 , wherein the at least one amine is a primary amine having a total carbon count of less than 6.8. The method according to claim 1 , wherein the at least one amine is a carbon-bridged diamine having a carbon count of 1 claim 1 , 2 claim 1 , 3 claim 1 , 4 claim 1 , 5 claim 1 , 6 claim 1 , 7 claim 1 , 8 claim 1 , or 9.9. The method according to claim 1 , wherein the at least one amine is a carbon-bridged diamine having a carbon count less than 10.10. The method according to claim 1 , wherein the at least one ...

Functionalized long-chain hydrocarbon mono- and di-carboxylic acids and their use for the prevention or treatment of disease

This invention provides compounds of Formulae (IA), (IB), (IC), (ID), (IE), (IF), (IG), (IH), (IJ), (IK), (IL), (II), (III), (IIIA), and (IIIB); pharmaceutically acceptable salts and solvates thereof; and compositions thereof. This invention further provides methods for treating a disease, including but not limited to, liver disease or an abnormal liver condition; cancer (such as hepatocellular carcinoma or cholangiocarcinoma); a malignant or benign tumor of the lung, liver, gall bladder, bile duct or digestive tract; an intra- or extra-hepatic bile duct disease; a disorder of lipoprotein; a lipid-and-metabolic disorder; cirrhosis; fibrosis; a disorder of glucose metabolism; a cardiovascular or related vascular disorder; a disease resulting from steatosis, fibrosis, or cirrhosis; a disease associated with increased inflammation (such as hepatic inflammation or pulmonary inflammation); hepatocyte ballooning; a peroxisome proliferator activated receptor-associated disorder; an ATP citrate lyase disorder; an acetyl-coenzyme A carboxylase disorder; obesity; pancreatitis; or renal disease.

NOVEL FATTY ACIDS AND THEIR USE IN CONJUGATION TO BIOMOLECULES

The invention provides a conjugate comprising a biomolecule linked to a fatty acid via a linker wherein the fatty acid has the following Formulae A1, A2 or A3: 4. A conjugate according to wherein the linker comprises alkyl claim 1 , alkenyl claim 1 , cycloalkyl claim 1 , aryl claim 1 , heteroaryl claim 1 , heterocyclyl claim 1 , polyethylene glycol claim 1 , one or more natural or unnatural amino acids claim 1 , or combination thereof claim 1 , wherein each of the alkyl claim 1 , alkenyl claim 1 , cycloalkyl claim 1 , aryl claim 1 , heteroaryl claim 1 , heterocyclyl claim 1 , polyethylene glycol and/or the natural or unnatural amino acids are optionally combined and linked together or linked to the biomolecule and/or to the fatty acid moiety via a chemical group selected from —C(O)O— claim 1 , —OC(O)— claim 1 , —NHC(O)— claim 1 , —C(O)NH— claim 1 , —O— claim 1 , —NH— claim 1 , —S— claim 1 , —C(O)— claim 1 , —OC(O)NH— claim 1 , —NHC(O)—O— claim 1 , ═NH—O— claim 1 , ═NH—NH— or ═NH—N(alkyl)-; or an amide claim 1 , ester or a pharmaceutically acceptable salt thereof.7. A conjugate according to wherein the linker comprises one or more amino acids independently selected from histidine claim 1 , methionine claim 1 , alanine claim 1 , glutamine claim 1 , asparagine and glycine; or an amide claim 1 , an ester or a pharmaceutically acceptable salt thereof.8. A conjugate according to wherein the biomolecule is selected from: 1) human Growth Differentiation Factor 15 (GDF15) claim 1 , homologs claim 1 , variants claim 1 , mutants claim 1 , fragments and other modified forms thereof or a dimer thereof; 2) an APJ agonist peptide claim 1 , 3) oxytocin receptor agonist peptide claim 1 , 4) serelaxin claim 1 , 5) NPFF claim 1 , 6) a PIP peptide claim 1 , 7) an FGF23 peptide 8) AgRP peptide and 9) a siRNA; or an amide claim 1 , an ester or a pharmaceutically acceptable salt thereof.10. A mixture comprising the conjugate according to having Formula C and the conjugate according to ...

( ) (2R,3S)-2-AMINO-3-HYDROXY-3-PYRIDIN-4-YL-1-PYRROLIDIN-1-YL-PROPAN-1-ONE (L)-(+) TARTRATE SALT, ITS METHOD OF PRODUCTION AND USE

The present invention is directed to (−)-(2R,3S)-2-amino-3-hydroxy-3-pyridin-4-yl-1-pyrrolidin-1-yl-propan-1-one (L)-(+)tartrate salt, a pharmaceutical composition comprising said salt, a process for making said salt, and the use of said salt in the treatment of pain. 1. (−)-(2R ,3S)-2-amino-3-hydroxy-3-pyridin-4-yl-1-pyrrolidin-1-yl-propan-1-one (L)-(+)tartrate salt.2. The salt of claim 1 , which is crystalline.4. A pharmaceutical composition comprising the tartrate salt of claim 1 , and at least one pharmaceutically acceptable carrier.5. A method of treating pain in a mammal claim 1 , said method comprising administering to said mammal in need thereof claim 1 , a therapeutically effective amount of the salt of .6. The method of claim 5 , wherein said pain is chronic pain.7. A method of treating a cognitive disorder in a mammal claim 1 , said method comprising administering to said mammal in need thereof claim 1 , a therapeutically effective amount of the salt of .8. The method of claim 7 , wherein the cognitive disorder is selected from the group consisting of an agnosia claim 7 , an amnesia claim 7 , an aphasia claim 7 , an apraxia claim 7 , a delirium claim 7 , a dementia claim 7 , and a learning disorder.9. The method of claim 7 , wherein the cognitive disorder is selected from the group consisting of AIDS dementia complex claim 7 , Binswanger's disease claim 7 , dementia with Lewy Bodies claim 7 , frontotemporal dementia claim 7 , mild cognitive impairment claim 7 , multi-infarct dementia claim 7 , Pick's disease claim 7 , semantic dementia claim 7 , senile dementia claim 7 , and vascular dementia.10. The method of claim 8 , wherein the learning disorder is selected from the group consisting of Asperger's syndrome claim 8 , attention deficit disorder claim 8 , attention deficit hyperactivity disorder claim 8 , autism claim 8 , childhood disintegrative disorder claim 8 , and Rett syndrome.11. The method of claim 8 , wherein the aphasia is progressive non-fluent ...

Liquid composition

A liquid composition includes copper particles, an organic acid, and a solvent. The copper particle has a particle size of 0.5 μm˜30 μm which falls in a micron scale. The liquid composition performs reaction sintering by redox reactions taken place between the copper particles and an organic acid solution at a low temperature of 150° C. in order to produce a dense copper layer and improve the conventional micron-scale copper particles that requires a protective atmosphere for the high-temperature sintering before achieving the required densification. This liquid composition also prevents an excessive oxidation of the nano copper particles during the low-temperature sintering process and a failure of the dense sintering. Due to the agglomeration of nano copper particles, some areas have to be sintered first, so that the sintered products have a good uniformity of tissue and a low resistance below 0.04 ohm per square (Ω/□).

PURIFICATION OF LONG CHAIN DIACIDS

The present disclosure relates to methods for separating and purifying a long chain diacid from other long chain diacids, monocarboxylic acids, hydroxyl acids or alkanes by simulated or actual moving bed chromatography. 1. A method for separating a C6- to C18-carbon diacid from at least one impurity in a solution , comprising:(a) introducing a feed stream comprising a solution comprising at least one 6- to 18-carbon diacid and at least one impurity, the at least one impurity comprising a component more polar than the diacid, a component less polar than the diacid, or both, into a first zone of moving bed chromatography apparatus (MBCA) having one or more zones;(b) collecting a raffinate stream or an extract stream from the first zone of the MBCA, the raffinate stream comprising the diacid and one or more components more polar than the diacid, and the extract stream comprising the diacid and one or more components less polar than the diacid;(c) introducing the raffinate stream or the extract stream into a second zone of the MBCA;(d) collecting a second raffinate stream or a second extract stream from the second zone of the MBCA, the raffinate stream comprising the diacid and components more polar than the diacid, and the extract stream comprising the diacid and components less polar than the diacid;(e) introducing the second raffinate stream or the second extract stream into the first zone or the second zone of the MBCA;(f) optionally repeating steps (d) and (e) until a desired degree of separation is achieved; and(g) collecting a final raffinate stream or a final extract stream from a zone of the MBCA, the final raffinate stream or the extract stream comprising the diacid, thereby separating a C6- to C18-carbon diacid from the at least one impurity in the solution.2. A method for separating a C6- to C18-carbon diacid from at least one impurity in a solution , comprising:(a) introducing a feed stream comprising a solution comprising at least one 6- to 18-carbon ...

CHEMICAL COMPOUNDS

The present invention relates to novel compounds of polyfunctionalized polyethylene and polypropylene glycols, their synthesis and their use, in particular as tracers in applications related to oil and gas production, and especially as specific markers of various target fluids. 1. A compound with the following generic structure{'br': None, 'sup': 1', '2', '3', '4', '5', '6', '7', '8', '9, 'sub': 2', 'n', '2', 'm', 'p, 'RRR—(—OCHR—CH—)—R—[(—CH—CHRO)—RRR]'}{'sup': '5', 'wherein the core unit Ris further connected to 2-4 units by carbon, ether or ester bonds;'}{'sup': 4', '6, 'sub': '3', 'Rand Ris H or —CHto give PEG or PPG chains;'}n and m are integers between 2 and 12 in which n could be the same or different from m;{'sup': '5', 'p is an integer between 1 and 3 depending on R;'}{'sup': 3', '7, 'Rand Rare aliphatic or aromatic hydrocarbon moieties with 2-40 carbon coupled to the PEG units or the PPG units by an ester or ether bond;'}{'sup': 1', '2', '8', '9, 'R, R, Rand Rare all H or identical or different hydrophilic functional groups preferably carboxylic, sulfonic or phosphonic acid groups; or salts, hydrates and solvates thereof;'}with the exception of 1,2-bis(2-(2-(benzyloxy)ethoxy)ethoxy)benzene.2. A compound according to claim 1 , wherein n and m are integers between 3 and 12.3. A compound according to claim 1 , wherein the core Runit consist of C claim 1 , O and H atoms.4. A compound according to claim 3 , wherein the core Runit consist of at least one halogen atom.5. A compound according to claim 3 , wherein the core Runit consist of at least one sulfonic acid or sulfonic acid salt.6. A compound according to claim 1 , wherein the core Runit is selected from aryl or aralkyl units with from 3 to 30 carbon atoms claim 1 , more preferably 3-24 carbon atoms claim 1 , specifically preferable 3-15 carbon atoms claim 1 , which also may contain one or more ether functions and/or ester functions or branched; or linear alkyl units with from 3 to 12 carbon atoms which ...

METHODS FOR STABILIZING WATER SENSITIVE CLAYS AND MIGRATING FINES IN SUBTERRANEAN FORMATIONS

Clay stabilization compositions include one or a plurality of triamino compounds and/or derivatives thereof, fluids containing an effective amount of the clay stabilization compositions and methods for making and using same. 1. A method comprising: a base fluid; and', [ {'br': None, 'sup': 1', '2', '3', '4', '5', '6, 'HC(RNRR)(R′NRR)(R″NRR)\u2003\u2003(I), and'}, 'one or more tri-functional primary amine compounds comprising one or more compounds of Formula (I), {'br': None, 'sup': +', '1', '2', '7', '+', '3', '4', '8', '+', '5', '6', '9, 'sub': 'n', 'HC(RNRRR)(R′NRRR)(R″NRRR)X\u2003\u2003(II),'}, 'one or more salts comprising one or more compounds of Formula (II)], 'an effective of a clay stabilizing composition comprising, the R, R′, and R″ groups are the same or different comprising hydrocarbyl linking groups including between 1 and 8 carbon atoms, and when the R, R′, and R″ groups include between 2 and 8 carbon atoms, then one or more carbon atoms may be replaced by acetate groups, or carbonyl groups,', {'sup': 1-6', '1-6', '7-9, 'claim-text': (a) absent and their associated nitrogen atoms do not bear a charge,', '(b) the same or different comprising a hydrogen atom and their associated nitrogen atoms bears a charge, or', '(c) the same or different comprising a hydrocarbyl group including between 1 and 24 carbon atoms and their associated nitrogen atoms bears a charge;', {'sup': 7-9', '7-9, 'provided that at least one of the Rgroups comprising a hydrogen atom or a hydrocarbyl group, and when the Rgroups including between 2 and 24 carbon atoms, then one or more carbon atoms may be replaced by oxygen atoms, acetate groups, or carbonyl groups;'}], 'the Rgroups are the same or different comprising hydrogen atoms or hydrocarbyl groups including between 1 and 6 carbon atoms, and when the Rgroups include between 2 and 6 carbon atoms, then one or more carbon atoms may be replaced by oxygen atoms, acetate groups, or carbonyl groups, the Rgroups are, 'the X groups are the ...

COMPOSITIONS AND METHODS FOR STABILIZING WATER SENSITIVE CLAYS AND MIGRATING FINES IN SUBTERRANEAN FORMATIONS

Clay stabilization compositions include one or a plurality of triamino compounds and/or derivatives thereof, fluids containing an effective amount of the clay stabilization compositions and methods for making and using same. 1. A clay stabilizing composition comprising one or a plurality of tri-functional primary amines and/or derivatives thereof , where the composition is capable of stabilizing swelling clays and migrating fines when drilling or stimulation fluid including an effective amount of the clay stabilizing composition is in contact with a subterranean formation.3. The composition of claim 2 , wherein the R claim 2 , R′ claim 2 , and R″ groups are the same or different and are linear alkyl linking groups having between 1 and 8 carbon atoms of the formula —(CH)— claim 2 , where m is an integer having a value between 2 and 8.4. The composition of claim 3 , wherein the R group is a linear alkyl group having between 1 and 3 carbon atoms claim 3 , the R′ group is linear alkyl group having between 2 and 4 carbon atoms claim 3 , and the R″ group is linear alkyl linking groups having between 3 and 5 carbon atoms.5. The composition of claim 4 , wherein each of the X groups is derived from an organic acid claim 4 , a mineral acid claim 4 , or an alkylating agent.6. The composition of claim 5 , wherein:the mineral acid is selected from the group consisting of hydrochloric acid, nitric acid, sulfuric acid, phosphoric acid, and mixtures thereof,the organic acid is selected from the group consisting of formic acid, acetic acid, citric acid, lactic acid, fumaric acid, and mixtures thereof, andthe strong alkylating agent is selected from the group consisting of benzyl chloride, diethyl sulfate, epichlorohydrin, 2-chloroethylether, and mixtures thereof.11. A drilling or simulating fluid composition comprising:an effective amount clay stabilizing composition comprising one or a plurality of tri-functional primary amines and/or derivatives thereof, where the composition is ...

COMPLEXES OF 1-METHYLCYCLOPROPENE WITH METAL COORDINATION POLYMER NETWORKS

Disclosed are adsorption complexes that include 1-methylcyclopropene (1-MCP) and a metal coordination polymer network (MCPN), wherein the MCPN is a porous material, and the 1-MCP is adsorbed into the MCPN. Also disclosed are kits for containing 1-MCP that include the adsorption complex in a 1-MCP-impermeable package. Also disclosed are methods of releasing 1-methylcyclopropene (1-MCP) from the kit that include the application of aqueous fluids, heat, and/or pressure. 1. An adsorption complex comprising 1-methylcyclopropene (1-MCP) and a metal coordination polymer network (MCPN) , wherein the MCPN is a porous material , and the 1-MCP is adsorbed into the MCPN.2. The adsorption complex of claim 1 , wherein the MCPN has a mean pore diameter of 1 to 50 Å.3. The adsorption complex of claim 1 , wherein the MCPN is a magnesium coordination polymer network or a calcium coordination polymer network.4. The adsorption complex of claim 1 , wherein the MCPN comprises a metal node claim 1 , and wherein the metal node is Mg claim 1 , Mn claim 1 , Ca claim 1 , Cu claim 1 , Al claim 1 , Zn claim 1 , Fe claim 1 , or Co.5. The adsorption complex of claim 1 , wherein the MCPN is magnesium formate; [Ca(4 claim 1 ,4′-sulfonyldibenzoate).HO]; Cu-TDPAT (also referred to as 2 claim 1 ,4 claim 1 ,6-tris(3 claim 1 ,5-dicarboxylphenylamino)-1 claim 1 ,3 claim 1 ,5-triazine); Zn(tcbpe) (also referred to as the reaction product of tetra-(4-bromo-phenyl)ethylene (tpe-Br) and 4-(methoxycarbonyl)phenylboronic acid); [Co(biphenyldicarboxylate)4 claim 1 ,4′bipyridine].4DMF.HO; [Co(biphenyldicarboxy-late)(4 claim 1 ,4′bipyridine)]0.5DMF; [Zn(biphenyldicarboxylate)(1 claim 1 ,2-bipyridylethene)].2DMF claim 1 , Mg(CC—C—H—CO); aluminum terephthalate; Cu(benzene-1 claim 1 ,3 claim 1 ,5-tricarboxylate); Fe(1 claim 1 ,3 claim 1 ,5-benzenetricarboxylate); 2-methylimidazole zinc salt; Co(2-methylimidazole); or Al(OH)fumarate.6. The adsorption complex of claim 1 , wherein the MCPN is thermally stable at a ...

POLYMERS PREPARED FROM MEVALONOLACTONE AND DERIVATIVES

Described herein polymer precursor compounds (aka polymer building blocks) of derived from biobased compounds, and specifically biobased mevalonolactone and its related derivatives. Through oxidation these biobased precursors can be reacted to yield building blocks for (unsaturated-) polyesters, polyester polyols and polyamides, as well as precursors for glycidyl esters and omega-alkenyl esters. Through reduction, these biobased precursors can be reacted to yield building blocks for (unsaturated-) polyesters, polyester polyols, polycarbonates, as well as precursors for glycidyl ethers and omega-alkenyl ethers. Through nucleophilic ring opening and/or amidation, these biobased precursors can be reacted to yield building blocks for polyester polyols, chain-extender for polyurethanes, or polyester-amides. 2. The compound of claim 1 , wherein each Y is —N(H) or —N(R).3. The compound of claim 1 , wherein each Ris selected from the group consisting of C-Calkyls.4. The compound of claim 1 , wherein Q is a linear hydrocarbyl selected from the group consisting of C-Calkyls.5. The compound of claim 1 , wherein said compound has a 14C/12C ratio greater than zero.6. A biobased polymer comprising recurring monomeric units synthesized from a compound according to .8. The compound of claim 1 , wherein each Ris selected from the group consisting of C-Calkyls.9. The compound of claim 7 , wherein said compound has a 14C/12C ratio greater than zero.10. A biobased polymer comprising recurring monomeric units synthesized from a compound according to .12. The compound of claim 11 , wherein each Y is —N(H) or —N(R).13. The compound of claim 11 , wherein each Ris selected from the group consisting of C-Calkyls.14. The compound of claim 11 , wherein Q is a linear hydrocarbyl selected from the group consisting of C-Calkyls15. The compound of claim 11 , wherein said compound has a 14C/12C ratio greater than zero.16. A biobased polymer comprising recurring monomeric units synthesized from a ...

Quaternary ammonium compounds as fuel or lubricant additives

A quaternary ammonium compound which is the reaction product of: (a) a tertiary amine having a molecular weight of less than 1000; (b) an acid-activated alkylating agent; and (c) a diacid including an optionally substituted hydrocarbyl moiety having at least (5) carbon atoms.

PURIFICATION OF LONG CHAIN DIACIDS

The present disclosure relates to methods for separating and purifying a long chain diacid from other long chain diacids, monocarboxylic acids, hydroxyl acids or alkanes by simulated or actual moving bed chromatography. 1. A method for separating a C6- to C18-carbon diacid from at least one impurity in a solution , the method comprising either: (b) collecting a raffinate stream or an extract stream from the first zone of the MBCA, the raffinate stream comprising the diacid and components more polar than the diacid, and the extract stream comprising the diacid and components less polar than the diacid,', '(c) introducing the raffinate stream or the extract stream into a second zone of the MBCA,', '(d) collecting a second raffinate stream or a second extract stream from the second zone of the MBCA, the raffinate stream comprising the diacid and components more polar than the diacid, and the extract stream comprising the diacid and components less polar than the diacid,', '(e) introducing the second raffinate stream or the second extract stream into the first zone or the second zone of the MBCA,', '(f) optionally repeating steps (d) and (e) until a desired degree of separation is achieved, and', '(g) collecting a final raffinate stream or a final extract stream from a zone the MBCA, the final raffinate stream or the extract stream comprising the diacid, thereby separating a C6- to C18-carbon diacid from the at least one impurity in the solution; or, '(1) (a) introducing a feed stream comprising a solution comprising at least one 6- to 18-carbon diacid and at least one impurity, the at least one impurity comprising a component more polar than the diacid, a component less polar than the diacid, or both, into a first zone of moving bed chromatography apparatus (MBCA) having one or more zones,'} (b) collecting a raffinate stream or an extract stream from the MBCA, the raffinate stream comprising and diacid and components more polar than the diacid, and the extract stream ...

Salts of an epidermal growth factor receptor kinase inhibitor

The present invention provides a salt form and compositions thereof, which are useful as an inhibitor of EGFR kinases and which exhibits desirable characteristics for the same.

SILVER INK

Provided is a silver ink including, as a major component, a silver malonate precursor represented by Formula 1 or Formula 2. 3. The silver ink according to claim 1 , wherein Rand Rare each independently selected from the group consisting of hydrogen claim 1 , methyl claim 1 , ethyl claim 1 , n-propyl claim 1 , iso-propyl claim 1 , n-butyl claim 1 , iso-butyl claim 1 , t-butyl claim 1 , n-pentyl claim 1 , amyl claim 1 , n-hexyl claim 1 , 2-ethylhexyl claim 1 , n-heptyl claim 1 , octyl claim 1 , iso-octyl claim 1 , nonyl claim 1 , decyl claim 1 , dodecyl claim 1 , hexadecyl claim 1 , octadecyl claim 1 , docodecyl claim 1 , cyclopropyl claim 1 , cyclopentyl claim 1 , cyclohexyl claim 1 , allyl claim 1 , propargyl claim 1 , acetyl claim 1 , benzoyl claim 1 , hydroxyethyl claim 1 , methoxyethyl claim 1 , 2-hydroxypropyl claim 1 , methoxypropyl claim 1 , aminoethyl claim 1 , cyanoethyl claim 1 , mercaptoethyl claim 1 , chloroethyl claim 1 , methoxy claim 1 , ethoxy claim 1 , butoxy claim 1 , hexyloxy claim 1 , phenoxy claim 1 , methoxyethoxyethyl claim 1 , methoxyethoxyethoxyethyl claim 1 , imidazolyl claim 1 , carboxymethyl claim 1 , trimethoxysilylpropyl claim 1 , triethoxysilylpropyl claim 1 , phenyl claim 1 , methoxyphenyl claim 1 , cyanophenyl claim 1 , tolyl claim 1 , benzyl claim 1 , and derivatives thereof.4. A silver ink comprising the silver malonate precursor according to and one or more additives selected from the group consisting of solvents claim 1 , complexing agents claim 1 , resins claim 1 , stabilizers claim 1 , dispersants claim 1 , reducing agents claim 1 , coupling agents claim 1 , leveling agents claim 1 , surfactants claim 1 , wetting agents claim 1 , thickeners claim 1 , and thixotropic agents.5. The silver ink according to claim 4 , wherein the ink has a viscosity in the range of 0.1 to 2 claim 4 ,000 cps claim 4 , as measured at room temperature 20° C.6. A silver ink as a hybrid ink produced by mixing or reacting the silver ink according to with ...

Chemical compounds

The present invention relates to novel compounds of polyfunctionalized polyethylene and polypropylene glycols, their synthesis and their use, in particular as tracers in applications related to oil and gas production, and especially as specific markers of various target fluids.

Acrylamide compounds as histamine h3 receptor ligands

The present invention relates to novel acrylamide compounds of formula (I), and their pharmaceutically acceptable salts and process of their preparation. (The chemical formula should be inserted here.) The compounds of formula (I) are useful in the treatment of various disorders that related to Histamine H 3 receptors.

Cosmetic Compositions and Methods for Using Same to Improve the Aesthetic Appearance of Skin

The present invention relates to compositions useful in treating hyperpigmentation and the various signs of dermatological aging in human skin. The present invention also relates to cosmetic compositions and methods of using such compositions that improve the aesthetic appearance of skin. Further, the present invention relates to methods of applying the compositions to the skin to effect treatment and to improve the aesthetic appearance of skin, particularly, by providing anti-aging benefits to the skin. 2. The composition of claim 1 , wherein the Formula I compound is present from about 0.0001 wt % to about 98 wt % based on the total weight of the composition.3. The composition of claim 1 , wherein the Formula I compound is present from about 0.001 wt % to about 30 wt % based on the total weight of the composition.4. The cosmetic composition of claim 1 , wherein the Formula I compound is 3 claim 1 ,3′-thiodipropionic acid.5. The cosmetic composition of claim 1 , further comprising an ingredient selected from the group consisting of hydroquinone claim 1 , ascorbic acid claim 1 , licorice extract claim 1 , retinoid claim 1 , bisabolol claim 1 , salicylic acid claim 1 , an oxa acid claim 1 , oxa diacid claim 1 , an alpha hydroxy acid claim 1 , a beta hydroxy acid claim 1 , a keto acid claim 1 , and any combination thereof.6. The cosmetic composition of claim 5 , wherein the ingredient is selected from the group consisting of: lactic acid claim 5 , glycolic acid claim 5 , 3 claim 5 ,6 claim 5 ,9-trioxaundecanedioic acid claim 5 , and any combination thereof.7Gymnostemma pentaphyllumStenolama chusanaMorinda citrifoliaButea frondosaNaringi crenulataferutinin, Ilex purpureaAsmunda japonicarhapontin, Uncaria gambirLigusticum chianxiongAzadirachta indicaAframomum melegueata. The cosmetic composition of claim 1 , further comprising an ingredient selected from the group consisting of palmatoyl tetrapeptide-3 claim 1 , and/or an extract therefrom claim 1 , and/or an extract ...

SALTS OF AN EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR

The present invention provides a salt form and compositions thereof, which are useful as an inhibitor of EGFR kinases and which exhibits desirable characteristics for the same. 132-. (canceled)34. The composition of claim 33 , wherein the composition comprises at least about 90% by weight of Compound 2.35. The composition of claim 34 , wherein the composition comprises at least about 95% by weight of Compound 2.36. The composition of claim 35 , wherein the composition comprises at least about 97% by weight of Compound 2.37. The composition of claim 36 , wherein the composition comprises at least about 98% by weight of Compound 2.38. The composition of claim 37 , wherein the composition comprises at least about 99% by weight of Compound 2.39. The composition of claim 33 , wherein the composition contains no more than 5.0 area percent HPLC of total organic impurities relative to the total area of an HPLC chromatogram of Compound 2.40. The composition of claim 39 , wherein the composition contains no more than 3.0 area percent HPLC of total organic impurities relative to the total area of an HPLC chromatogram of Compound 2.41. The composition of claim 40 , wherein the composition contains no more than 1.5 area percent HPLC of total organic impurities relative to the total area of an HPLC chromatogram of Compound 2.42. The composition of claim 41 , wherein the composition contains no more than 1.0 area percent HPLC of total organic impurities relative to the total area of an HPLC chromatogram of Compound 2.43. The composition of claim 33 , wherein X is hydrobromic acid.45. The composition of claim 44 , wherein Compound 2 is at least 90% crystalline.46. The composition of claim 45 , wherein Compound 2 is at least 95% crystalline.47. The composition of claim 46 , wherein Compound 2 is at least 97% crystalline.48. The composition of claim 47 , wherein Compound 2 is at least 98% crystalline.49. The composition of claim 48 , wherein Compound 2 is at least 99% crystalline.50. ...

SALT OF MONOCYCLIC PYRIDINE DERIVATIVE AND CRYSTAL THEREOF

The present invention provides salts consisting of an organocarboxylic acid selected from the group consisting of succinic acid and maleic acid and a compound represented by formula (I) 2. The salt according to claim 1 , which is a succinate salt.3. The salt according to claim 2 , which is 5-({2-[({4-[1-(2-hydroxyethyl)piperidin-4-yl]phenyl}carbonyl)amino]pyridin-4-yl}oxy)-6-(2-methoxyethoxy)-N-methyl-1H-indole-1-carboxamide 1.5 succinate salt.4. The salt according to claim 2 , which is 5-({2-[({4-[1-(2-hydroxyethyl)piperidin-4-yl]phenyl}carbonyl)amino]pyridin-4-yl}oxy)-6-(2-methoxyethoxy)-N-methyl-1H-indole-1-carboxamide 0.5 succinate salt.5. The salt according to claim 1 , which is 5-({2-[({4-[1-(2-hydroxyethyl)piperidin-4-yl]phenyl}carbonyl)amino]pyridin-4-yl}oxy)-6-(2-methoxyethoxy)-N-methyl-1H-indole-1-carboxamide maleate salt.8. A crystal of 5-({2-[({4-[1-(2-hydroxyethyl)piperidin-4-yl]phenyl}carbonyl)amino]pyridin-4-yl}oxy)-6-(2-methoxyethoxy)-N-methyl-1H-indole-1-carboxamide 1.5 succinate salt claim 1 , having a diffraction peak at a diffraction angle (2θ6 0.2°) of 22.4° in a powder X-ray diffraction.9. The crystal according to claim 8 , having diffraction peaks at diffraction angles (2θ6 0.2°) of 22.4° claim 8 , 25.3° and 23.3° in a powder X-ray diffraction.10. A crystal (a) of 5-({2-[({4-[1-(2-hydroxyethyl)piperidin-4-yl]phenyl}carbonyl)amino]pyridin-4-yl}oxy)-6-(2-methoxyethoxy)-N-methyl-1H-indole-1-carboxamide 0.5 succinate salt claim 8 , having a diffraction peak at diffraction angles (2θ±0.2°) of 19.8° in a powder X-ray diffraction.11. A crystal of 5-({2-[({4-[1-(2-hydroxyethyl)piperidin-4-yl]phenyl}carbonyl)amino]pyridin-4-yl}oxy)-6-(2-methoxyethoxy)-N-methyl-1H-indole-1-carboxamide maleate salt claim 8 , having a diffraction peak at a diffraction angle (2θ±0.2°) of 20.10 in a powder X-ray diffraction.12. A crystal of 5-({2-[({4-[1-(2-hydroxyethyl)piperidin-4-yl]phenyl}carbonyl)amino]pyridin-4-yl}oxy)-6-(2-methoxyethoxy)-N-methyl-1H-indole-1- ...

MOLD RELEASE AGENT FOR WATER GLASS-CONTAINING SAND MOLD MOLDING

[Task] There is provided a mold release agent for forming a water glass-containing sand mold with high release properties which can prevent attachment of a water glass to a flask and the accumulation of the water glass on the flask in the formation of the sand mold when using the water glass as a binder. 1. A mold release agent for forming a water glass-containing sand mold characterized by comprising an organic compound having a proton-donating functional group that reacts with water glass to produce silicon dioxide in the functional group.2. The mold release agent for forming a water glass-containing sand mold according to claim 1 , characterized in that the proton-donating functional group is a carboxyl group.3. A mold release agent for forming a water glass-containing sand mold characterized by comprising a chain organic compound having a carboxyl group in an amount of more than 0.0001 mol/kg and 0.0500 mol/kg or less. The present invention relates to a mold release agent used in forming a sand mold using water glass as a binder (mold release agent for forming a water glass-containing sand mold).Conventionally, a technique of forming a casting mold using foundry sand to which water glass is added was used (Patent Document 1). This technique is a technique in which 1 to 4% (% by weight) of water glass is added and kneaded in foundry sand, and a casting mold is formed from the kneaded mixture, and then dried.Patent Document 1: Japanese Patent Application Publication No. H9-174194 (JP H9-174194 A)When a sand mold (casting mold: main mold and core) is formed using water glass as a binder as in BACKGROUND ART described above, water glass (sodium silicate) is easily attached (fixed) to a flask used in forming the sand mold, and the sand mold is likely to collapse during mold release. This is because water glass has high affinity to another substance such as metal.Water glass is likely to accumulate on the flask, even though the sand mold can be released. The flask has ...

SALT CRYSTALS

The present invention relates to acid addition salt and salt crystals of (6aR,9aS)-5,6a,7,8,9,9a-hexahydro-5-methyl-3-(phenylamino)-2-((4-(6-fluoropyridin-2-yl)phenyl)methyl)-cyclopent[4,5]imidazo[1,2-a]pyrazolo[4,3-e]pyrimidin-4(2H)-one, composition comprising the same and the method of making and using such salt and crystal 1. The compound (6aR ,9aS)-5 ,6a ,7 ,8 ,9 ,9a-hexahydro-5-methyl-3-(phenylamino)-2-((4-(6-fluoropyridin-2-yl)phenyl)methyl)-cyclopent[4 ,5]imidazo[1 ,2-a]pyrazolo[4 ,3-e]pyrimidin-4(2H)-one in an acid addition salt form.2. The salt according to claim 1 , wherein said salt is in crystallinic form.3. The salt crystals according to selected from mesylate claim 2 , fumarate claim 2 , L-tartrate and phosphate salt crystals.4. The salt crystals according to claim 2 , wherein the salt crystals exhibit an X-ray powder diffraction pattern comprising at least five peaks having 2-theta angle values selected from the group consisting of 11.5 claim 2 , 12.1 claim 2 , 16.5 claim 2 , 16.9 claim 2 , 18.2 claim 2 , 18.9 claim 2 , 19.2 claim 2 , 19.6 claim 2 , 20.6 claim 2 , 21.3 claim 2 , 21.6 claim 2 , 22.9 claim 2 , 23.6 claim 2 , 24.4 claim 2 , 25.7 claim 2 , 27.7 claim 2 , 28.2 and 31.3 degrees claim 2 , wherein the XRPD pattern is measured in a diffractometer using copper anode; or at least five peaks having d-spacing values selected from the group consisting of 7.68 claim 2 , 7.28 claim 2 , 5.36 claim 2 , 5.23 claim 2 , 4.87 claim 2 , 4.71 claim 2 , 4.62 claim 2 , 4.52 claim 2 , 4.31 claim 2 , 4.17 claim 2 , 4.12 claim 2 , 3.88 claim 2 , 3.77 claim 2 , 3.65 claim 2 , 3.46 claim 2 , 3.22 claim 2 , 3.17 and 2.86 Å; and wherein the values have a ±10% deviation.5. The salt crystals according to claim 2 , wherein the salt crystals exhibit an X-ray powder diffraction pattern comprising at least five peaks having 2-theta angle values selected from 7.2 claim 2 , 8.0 claim 2 , 10.1 claim 2 , 11.2 claim 2 , 11.7 claim 2 , 12.5 claim 2 , 13.2 claim 2 , 14.4 claim 2 ...

BRANCHED FLUORINE-CONTAINING COMPOUND

A novel branched fluorine-containing compound represented by formula (1): 2. The branched fluorine-containing compound according to claim 1 , wherein L is a trivalent carbon-containing linker moiety represented by formula (L-1-1) or a tetravalent carbon-containing linker moiety represented by formula (L-1-2); and Y claim 1 , in each occurrence claim 1 , is the same or different and represents (1) a divalent linking group selected from the group consisting of —O— claim 1 , —CONR— claim 1 , and —NRCO— or (2) a bond.3. The branched fluorine-containing compound according to claim 2 , wherein X is an alkylene chain or a bond.4. The branched fluorine-containing compound according to claim 3 , wherein X is a bond.5. The branched fluorine-containing compound according to claim 1 , wherein L is a tetravalent carbon-containing linker moiety represented by formula (L-2); and at least one Y is —O— claim 1 , —COO— claim 1 , —OCO— claim 1 , —CONR— claim 1 , or —NRCO—.6. The branched fluorine-containing compound according to claim 1 , wherein n1 is 1 or 2; and n2 is 2.7. A surfactant comprising the branched fluorine-containing compound according to .8. An aqueous dispersant comprising the branched fluorine-containing compound according to . The present invention relates to a branched fluorine-containing compound.Patent Literature 1 discloses, as a conventional branched fluorine-containing compound, a branched fluorine-containing compound useful as a surfactant.PTL 1: WO2014/012661However, there is a further need to develop a branched fluorine-containing compound useful as a novel fluorine-containing surfactant (in particular, an interface promoter, a viscosity reducer, a dispersant, or an emulsifier).The present inventors conducted extensive research, and found that the above object can be achieved by a branched fluorine-containing compound represented by formula (1):(Rf—YLX-A)  (1)wherein L represents (1) a trivalent carbon-containing linker moiety represented by formula (L-1-1 ...

COMPLEXES OF 1-METHYLCYCLOPROPENE WITH METAL COORDINATION POLYMER NETWORKS

Disclosed are adsorption complexes that include 1-methylcyclopropene (1-MCP) and a metal coordination polymer network (MCPN), wherein the MCPN is a porous material, and the 1-MCP is adsorbed into the MCPN. Also disclosed are kits for containing 1-MCP that include the adsorption complex in a 1-MCP-impermeable package. Also disclosed are methods of releasing 1-methylcyclopropene (1-MCP) from the kit that include the application of aqueous fluids, heat, and/or pressure. 122.-. (canceled)23. A composition comprising:i. 1-methylcyclopropene (1-MCP) and{'sub': 2', '2', '2', '2', '3', '2', '10', '6', '2', '3', '3', '2', '2, 'ii. a metal coordination polymer network (MCPN), wherein the MCPN is a porous material selected from the group consisting of magnesium formate; [Ca(4,4′-sulfonyldibenzoate).HO]; Cu-2,4,6-tris(3,5-dicarboxylphenylamino)-1,3,5-triazine); Zn(tcbpe) (wherein tcbpe is a reaction product of tetra-(4-bromo-phenyl)ethylene (tpe-Br) and 4-(methoxycarbonyl) phenylboronic acid); [Zn(biphenyldicarboxylate)(1,2-bipyridylethene)].2DMF, Mg(OC—C—H—CO); aluminum terephthalate; Cu(benzene-1,3,5-tricarboxylate); Fe(1,3,5-benzenetricarboxylate); 2-methylimidazole zinc salt; Co(2-methylimidazole); and Al(OH)fumarate,'}wherein the 1-MCP is adsorbed to a surface of the MCPN.24. The composition of claim 23 , wherein the surface of the MCPN is a surface defining a pore in the MCPN.25. The composition of claim 23 , wherein the surface of the MCPN is a surface outside of a pore in the MCPN.26. The composition of claim 23 , wherein the MCPN is [Ca(4 claim 23 ,4′-sulfonyldibenzoate).HO].27. The composition of claim 23 , wherein the MCPN is Cu-2 claim 23 ,4 claim 23 ,6-tris(3 claim 23 ,5-dicarboxylphenylamino)-1 claim 23 ,3 claim 23 ,5-triazine).28. The composition of claim 23 , wherein the MCPN is Zn(tcbpe) (wherein tcbpe is a reaction product of tetra-(4-bromo-phenyl)ethylene (tpe-Br) and 4-(methoxycarbonyl) phenylboronic acid).29. The composition of claim 23 , wherein the MCPN ...

Complexes of 1-methylcyclopropene with metal coordination polymer networks

Disclosed are adsorption complexes that include 1-methylcyclopropene (1-MCP) and a metal coordination polymer network (MCPN), wherein the MCPN is a porous material, and the 1-MCP is adsorbed into the MCPN. Also disclosed are kits for containing 1-MCP that include the adsorption complex in a 1-MCP-impermeable package. Also disclosed are methods of releasing 1-methylcyclopropene (1-MCP) from the kit that include the application of aqueous fluids, heat, and/or pressure.

Branched fluorine-containing compound

A novel branched fluorine-containing compound represented by formula (1):wherein L represents a predetermined carbon-containing linker moiety; Rf, in each occurrence, is the same or different and represents fluoroalkyl optionally having at least one ether bond; Y, in each occurrence, is the same or different and represents a predetermined divalent linking group or a bond; RY, in each occurrence, is the same or different and represents hydrogen or an organic group; L represents an (n1+n2)-valent carbon-containing linker moiety having at least one carbon atom; n1 represents a number greater than or equal to 1; n2 represents a number greater than or equal to 1; n1+n2 is a number from 3 to 6; X, in each occurrence, is the same or different and represents a divalent linking group or a bond; A, in each occurrence, is the same or different and represents -ArSO3M or the like; M, in each occurrence, is the same or different and represents hydrogen, —NR4, or a metal salt; and R represents hydrogen or a C1-4 organic group.

Deuterated Tetramethyl Dioic Acids, Compositions Comprising Them And Uses Thereof

This invention relates to deuterated tetramethyl dioic acids, compositions comprising them and uses thereof in the treatment of Metabolic Syndrome and any diseases, disorders or symptoms associated therewith. 4. A compound according to claim 1 , wherein at least one of R-Ris D.5. A compound according to claim 1 , wherein at least one of R-Ris CD.6. A compound according to claim 1 , wherein at least one of R-Ris CD.7. A compound according to claim 1 , wherein at least one of R-Ris D.8. A compound according to any one of claim 1 , wherein L is any one of —(CH)— and —(CH)—.9. (canceled)10. A compound according to claim 1 , wherein at least one of R-Ris D and at least one of R-Ris CD.11. A compound according to claim 1 , wherein at least one of R-Ris CDand at least one of R-Ris D.19. A composition comprising a compound according to or any salts claim 1 , esters claim 1 , anhydrides or prodrugs thereof.2027-. (canceled)28. A method of treating a disease claim 1 , condition claim 1 , symptom or disorder associated with Metabolic Syndrome in a subject claim 1 , said method comprising administering to said subject an effective amount of at least one compound as defined in .29. A method according to claim 28 , wherein said disease claim 28 , condition or disorder associated with Metabolic Syndrome is selected from dyslipidemia claim 28 , diabetes claim 28 , obesity claim 28 , cancer claim 28 , hypertension and neurodegeneration. This invention relates to deuterated tetramethyl dioic acids, compositions comprising them and uses thereof in the treatment of Metabolic Syndrome and any diseases, disorders or symptoms associated therewith.U.S. Pat. No. 4,634,795 discloses long-chain alpha, omega-di-carboxylic acids and derivatives for the treatment of obesity, hyperlipidemia and maturity-onset diabetes. US2002049345 discloses carboxylic acids and derivatives thereof, compositions comprising them for the treatment of obesity, hyperlipidemia and maturity onset diabetes. US2009018199 ...

Method for producing a long chain dicarboxylic acid by fermentation, fermentation broth, treated fermentation broth and wastewater

The present invention discloses a method for producing a long chain dicarboxylic acid by fermentation as well as a fermentation broth, a treated fermentation broth and a wastewater. The salt content in the fermentation broth is controlled to be below 20% by the fermentation method of the present invention. The method for producing a long chain dicarboxylic acid by fermentation provided by the present invention can effectively reduce the amount of alkali used in the fermentation process and the amount of acid used in the subsequent extraction of the long chain dicarboxylic acid, thereby reducing the amount of salt in the whole production process of the long chain dicarboxylic acid. At the same time, the method of the present invention also has many advantages such as shortening the fermentation time, increasing the acid production, reducing the amount of medium, and suitable for the production of various types of long-chain dicarboxylic acids, etc. Compared with the existing production process, the method of the present invention not only has significant cost advantages, but also can effectively reduce the pressure on resource and environment, thus it has a very obvious value advantage in industrialization.

BRANCHED FLUORINE-CONTAINING COMPOUND

A novel branched fluorine-containing compound represented by formula (1): 2. The branched fluorine-containing compound according to claim 1 , wherein L is a trivalent carbon-containing linker moiety represented by formula (L-1-1) or a tetravalent carbon-containing linker moiety represented by formula (L-1-2); and Y claim 1 , in each occurrence claim 1 , is the same or different and represents (1) a divalent linking group selected from the group consisting of —O— claim 1 , —CONR— claim 1 , and —NRCO— or (2) a bond.3. The branched fluorine-containing compound according to claim 2 , wherein X is an alkylene chain or a bond.4. The branched fluorine-containing compound according to claim 3 , wherein X is a bond.5. The branched fluorine-containing compound according to claim 1 , wherein L is a tetravalent carbon-containing linker moiety represented by formula (L-2); and at least one Y is —O— claim 1 , —COO— claim 1 , —OCO— claim 1 , —CONR— claim 1 , or —NRCO—.6. The branched fluorine-containing compound according to claim 1 , wherein n1 is 1 or 2; and n2 is 2.7. A surfactant comprising the branched fluorine-containing compound according to .8. An aqueous dispersant comprising the branched fluorine-containing compound according to . The present invention relates to a branched fluorine-containing compound.Patent Literature 1 discloses, as a conventional branched fluorine-containing compound, a branched fluorine-containing compound useful as a surfactant.PTL 1: WO2014/012661However, there is a further need to develop a branched fluorine-containing compound useful as a novel fluorine-containing surfactant (in particular, an interface promoter, a viscosity reducer, a dispersant, or an emulsifier).The present inventors conducted extensive research, and found that the above object can be achieved by a branched fluorine-containing compound represented by formula (1):(Rf—YLX-A)  (1)wherein L represents (1) a trivalent carbon-containing linker moiety represented by formula (L-1-1 ...

Aliphatic Materials and Uses Thereof in Heating and Cooling Applications

Aliphatic materials and their use in passive heating and cooling applications are generally disclosed. In some embodiments, dibasic acids and esters (diesters) thereof and their use in passive heating and cooling applications are disclosed. In some embodiments, Cdibasic acids and esters thereof are disclosed, including their use in passive heating and cooling applications. In some embodiments, various olefins, including alkenes and olefinic acids and esters, are disclosed, including their use in passive heating and cooling applications. 2. The method of claim 1 , wherein Xis Calkylene or Calkenylene claim 1 , each of which is optionally substituted one or more times by substituents selected independently from R.3. The method of claim 1 , wherein Xis Calkylene claim 1 , which is optionally substituted one or more times by substituents selected independently from the group consisting of —OH and Coxyalkyl.4. The method of claim 1 , wherein Xis Calkylene claim 1 , which is optionally substituted one or more times by substituents selected independently from the group consisting of —OH and Coxyalkyl.5. The method of claim 1 , wherein Xis —(CH)— claim 1 , —(CH)— claim 1 , —(CH)— claim 1 , —(CH)— claim 1 , —(CH)— claim 1 , or —(CH)—.6. The method of claim 1 , wherein Xis —(CH)—.7. The method of claim 1 , wherein Ris a hydrogen atom.8. The method of claim 1 , wherein Ris Calkyl claim 1 , which is optionally substituted one or more times by substituents selected independently from R.918-. (canceled)19. The method of claim 1 , wherein Ris Coxyalkyl claim 1 , which is optionally substituted one or more times by substituents selected independently from the group consisting of —OH and Coxyalkyl.20. (canceled)21. The method of claim 1 , wherein Ris Ccycloalkyl claim 1 , which is optionally substituted one or more times by substituents selected independently from R.22. (canceled)23. The method of claim 1 , wherein Ris a hydrogen atom.24. The method of claim 1 , wherein Ris Calkyl ...

ACID LIQUID COMPACT WASHING AGENT INCLUDING HYDROXYCARBOXYLIC ACID, NON-IONIC SURFACTANT, AND AN-AMYLASE

The invention relates to liquid washing agents having a pH value of <6.5, preferably in the range of 2 to 5, containing, based on the total weight of the liquid washing agent, (i) 5 to 30% by weight, preferably 10 to 30% by weight, in particular 15 to 25% by weight of at least one hydroxycarboxylic acid having 2 to 8 carbon atoms, (ii) 15 to 55% by weight, preferably 20 to 55% by weight, in particular 35 to 50% by weight of at least one non-ionic surfactant, (iii) 0 to 20% by weight of water, and (iv) at least one α-amylase having a pH optimum of pH <7. Said liquid washing agents have an increased cleaning power, in particular on stains on the basis of components and residues from deodorants but also of grates, berries, tea and red wine residues. 1. A liquid washing agent , comprising , in relation to the total weight of the liquid washing agent ,(i) 5 to 30 wt. % of at least one hydroxycarboxylic acid having 2 to 8 carbon atoms and(ii) 15 to 55 wt. % of at least one non-ionic surfactant,(iii) 0 to 20 wt. % water,(iv) at least one α-amylase having a pH optimum of pH <7wherein the liquid washing agent has a pH value <6.5.2. The liquid washing agent according to claim 1 , wherein at least one aliphatic hydroxycarboxylic acid having 3 to 6 carbon atoms is included as said hydroxycarboxylic acid claim 1 , and wherein said hydroxycarboxylic acid is linear or branched.3. The liquid washing agent according to claim 1 , wherein at least one hydroxycarboxylic acid selected from the group consisting of citric acid claim 1 , lactic acid claim 1 , tartaric acid claim 1 , hydroxysuccinic acid claim 1 , and salicylic acid.4. The liquid washing agent according to claim 1 , wherein the at least one non-ionic surfactant comprises a fatty alcohol ethoxylate.5. The liquid washing agent according to claim 1 , wherein the agent comprises at least one α-amylase having a pH optimum of pH 1 to pH 6.6Aspergillus oryzaePenicillium oxalicumMicrococcusBacillusFerdowsicous.. The liquid washing ...

ACID LIQUID COMPACT WASHING AGENT INCLUDING HYDROXYCARBOXYLIC ACID, NON-IONIC SURFACTANT, AND AN ENZYME

The invention relates to liquid washing agents having a pH value of <6.5, preferably in the range of 2 to 5, containing, based on the total weight of the liquid washing agent, (i) 5 to 30% by weight, preferably 10 to 30% by weight, in particular 15 to 25% by weight of at least one hydroxycarboxylic acid having 2 to 8 carbon atoms, (ii) 15 to 55% by weight, preferably 20 to 55% by weight, in particular 35 to 50% by weight of at least one non-ionic surfactant, (iii) 0 to 20% by weight of water, and (iv) at least one enzyme having a pH optimum of pH<7. Said liquid washing agents have an increased cleaning power, in particular on stains on the basis of components and residues from deodorants but also of grates, berries, tea and red wine residues. 1. A liquid washing agent , containing in relation to the total weight of the liquid washing agent(i) 5 to 30 wt. % of at least one hydroxycarboxylic acid having 2 to 8 carbon atoms and(ii) 15 to 55 wt. % of at least one non-ionic surfactant,(iii) 0 to 20 wt. % water,(iv) at least one protease having a pH optimum of pH<7wherein the liquid washing agent has a pH value<6.5.2. The liquid washing agent according to claim 1 , wherein at least one aliphatic hydroxycarboxylic acid having 3 to 6 carbon atoms is included as said hydroxycarboxylic acid claim 1 , wherein said hydroxycarboxylic acid is linear or branched.3. The liquid washing agent according to claim 1 , wherein at least one hydroxycarboxylic acid selected from the group consisting of citric acid claim 1 , lactic acid claim 1 , tartaric acid claim 1 , hydroxysuccinic acid claim 1 , and salicylic acid.4. The liquid washing agent according to claim 1 , wherein the at least one non-ionic surfactant comprises a fatty alcohol ethoxylate.5. The liquid washing agent according to claim 1 , wherein the agent comprises at least one protease having a pH optimum from pH 1 to pH 6.6. The liquid washing agent according to claim 1 , wherein said protease is selected from at least one ...

Method for producing 3,5-dimethyldodecanoic acid

Provided is a process for producing 3,5-dimethyldodecanoic acid, which is an active ingredient of the pheromone of California prionus. More specifically provided is a method for producing 3,5-dimethyldodecanoic acid (5) comprising the steps of converting 2-methylnonyl halide (1) to a 2-methylnonyl metal reagent (2), and reacting the 2-methylnonyl metal reagent (2) with 2-ethylidene malonic acid ester (3) to form 2-(1,3-dimethyldecyl)malonic acid ester (4) as a result of 1,4-addition of the 2-methylnonyl metal reagent (2) to the 2-ethylidene malonic acid ester (3), as shown in the following scheme:

Novel fatty acids and their use in conjugation to biomolecules

The invention provides a conjugate comprising a biomolecule linked to a fatty acid via a linker wherein the fatty acid has the following Formulae A1, A2 or A3: wherein R 1 , R 2 , R 3 , R 4 , Ak, n, m and p are defined herein. The invention also relates to a method for manufacturing the conjugate of the invention such as GDF15 conjugate, and its therapeutic uses such as treatment or prevention of metabolic disorders or diseases, type 2 diabetes mellitus, obesity, pancreatitis, dyslipidemia, alcoholic and nonalcoholic fatty liver disease/steatohepatitis and other progressive liver diseases, insulin resistance, hyperinsulinemia, glucose intolerance, hyperglycemia, metabolic syndrome, hypertension, cardiovascular disease, atherosclerosis, peripheral arterial disease, stroke, heart failure, coronary heart disease, diabetic complications (including but not limited to chronic kidney disease), neuropathy, gastroparesis and other metabolic disorders. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

Method of Treating Cancer

This invention is directed to the treatment of cancer, particularly castration-resistant prostate cancer and osteoblastic bone metastases, with a dual inhibitor of MET and VEGF.

PURIFICATION OF POLYCARBOXYLIC ACIDS

A process for purifying a polycarboxylic acid from a mixture is provided. Optionally, the mixture is an aqueous solution and optionally the process comprises an acidification step and/or the use of one or more organic solvents. Also provided in part are compositions of polycarboxylic acids. 1. A method for purifying a polycarboxylic acid of interest from an aqueous mixture , comprising: (a) reducing the pH of the aqueous medium comprising the polycarboxylic acid such that the polycarboxylic acid is precipitated from said medium; (b) contacting the precipitated polycarboxylic acid with at least one suitable organic solvent at one or more selected temperatures; (c) separating the polycarboxylic acid from the at least one suitable organic solvent; and (d) collecting the purified polycarboxylic acid.2. The method of wherein the aqueous solution is a fermentation broth.3. The method of claim 2 , wherein the polycarboxylic acid of interest is a dicarboxylic acid43. The method of any one of - claims 1 , comprising a separating process between (a) and (b).5. The method of claim 4 , wherein the polycarboxylic acid is chosen from azelaic acid claim 4 , sebacic acid claim 4 , UDDA claim 4 , DDDA claim 4 , brassylic acid claim 4 , TDDA claim 4 , thapsic acid claim 4 , traumatic acid claim 4 , octadecanedioic acid claim 4 , 9-octadecenedioic acid claim 4 , octadeca-c6 claim 4 ,c9-diene-1 claim 4 ,18-dioate octadeca-c3 claim 4 ,c6 claim 4 ,c9-triene-1 claim 4 ,18-dioate claim 4 , and icosanedioic acid.6. The method of wherein the polycarboxylic acid is DDDA.76. The method of any one of - claims 1 , wherein the organic solvent is an acid.8. The method of claim 7 , wherein the organic solvent is acetic acid.98. The method of any one of - wherein the organic solvent is heated to solubilize the polycarboxylic acid of interest.10. The method of wherein the organic solvent is slowly cooled after heating thereby precipitating the polycarboxylic acid of interest.11. The method of wherein ...

MEDICAL LUBRICANT

A medical lubricant may comprise a base oil. The medical lubricant can be used on a surgical device. 2. The formulation of claim 1 , wherein Ris H; or a salt thereof.3. The formulation of claim 1 , wherein Ris C-Calkyl claim 1 , and wherein each hydrogen atom in C-Calkyl is independently optionally substituted with halo claim 1 , hydroxy claim 1 , amino claim 1 , oxo claim 1 , or OR; or a salt thereof.5. The formulation of claim 1 , wherein Ris independently H claim 1 , C-Calkyl claim 1 , C-Calkenyl claim 1 , C-Calkynyl claim 1 , C-Calkyl claim 1 , C-Calkenyl claim 1 , C-Calkynyl claim 1 , and wherein each hydrogen atom in C-Calkyl claim 1 , C-Calkenyl claim 1 , C-Calkynyl claim 1 , C-Calkyl claim 1 , C-Calkenyl claim 1 , and C-Calkynyl is independently optionally substituted with halo claim 1 , hydroxy claim 1 , or amino; or a salt thereof.6. The formulation of claim 1 , wherein the base oil has a smoke point of at least 450° F. claim 1 , at least 475° F. claim 1 , at least 490° F. claim 1 , at least 500° F. claim 1 , or at least 510° F.7. The formulation of claim 1 , wherein at least the base oil is at least 40% by weight of the formulation.8. The formulation of claim 1 , wherein compound of formula I is at least 20% by weight of the base oil.10. The formulation of claim 1 , wherein the phospholipid or a salt thereof is at least 2% by weight of the formulation.11. The formulation of claim 1 , wherein the salt of formula II is calcium stearate.13. A method of coating an electrocautery device with a formulation according to claim 1 , the method comprising{'claim-ref': {'@idref': 'CLM-00001', 'claim 1'}, 'contacting a surface of an electrocautery device with the formulation according to .'}14. A method of preparing the formulation according claim 12 , comprising heating a base oil claim 12 ,mixing the base oil with a compound of formula V, andmixing the base oil with a phospholipid.15. The method of claim 14 , wherein the step of heating comprising heating the base ...

COMPLEXES OF 1-METHYLCYCLOPROPENE WITH METAL COORDINATION POLYMER NETWORKS

Disclosed are adsorption complexes that include 1-methylcyclopropene (1-MCP) and a metal coordination polymer network (MCPN), wherein the MCPN is a porous material, and the 1-MCP is adsorbed into the MCPN. Also disclosed are kits for containing 1-MCP that include the adsorption complex in a 1-MCP-impermeable package. Also disclosed are methods of releasing 1-methylcyclopropene (1-MCP) from the kit that include the application of aqueous fluids, heat, and/or pressure. 122.-. (canceled)23. A method for adsorbing 1-methyl cyclopropane (1-MCP) to a surface of a metal coordination polymer network (MCPN) comprising the steps of:a) generating 1-MCP in a first vessel; andb) adsorbing the 1-MCP to the surface of the MCPN in a second vessel.24. The method of claim 23 , wherein the MCPN comprises a metal node selected from Mg claim 23 , Mn claim 23 , Ca claim 23 , Cu claim 23 , Al claim 23 , Zn claim 23 , Fe claim 23 , Co claim 23 , or a combination thereof.25. The method of claim 23 , wherein the surface of the MCPN is a surface defining a pore in the MCPN.26. The method of claim 23 , wherein the surface of the MCPN is a surface outside of a pore in the MCPN.27. The method of claim 23 , wherein the metal node is Mg.28. The method of claim 23 , wherein the metal node is Mn.29. The method of claim 23 , wherein the metal node is Ca.30. The method of claim 23 , wherein the metal node is Cu.31. The method of claim 23 , wherein the metal node is Al.32. The method of claim 23 , wherein the metal node is Zn.33. The method of claim 23 , wherein the metal node is Fe.34. The method of claim 23 , wherein the method is a solid-based method.35. The method of claim 23 , wherein the method is a solution-based method.36. The method of claim 23 , wherein the MCPN is dried in a vacuum oven.37. The method of claim 36 , wherein the drying in the vacuum oven is performed at a temperature of about 100° C.38. The method of claim 23 , wherein the MCPN is continuously agitated during the step of ...

COMPLEXES OF 1-METHYLCYCLOPROPENE WITH METAL COORDINATION POLYMER NETWORKS

Disclosed are adsorption complexes that include 1-methylcyclopropene (1-MCP) and a metal coordination polymer network (MCPN), wherein the MCPN is a porous material, and the 1-MCP is adsorbed into the MCPN. Also disclosed are kits for containing 1-MCP that include the adsorption complex in a 1-MCP-impermeable package. Also disclosed are methods of releasing 1-methylcyclopropene (1-MCP) from the kit that include the application of aqueous fluids, heat, and/or pressure. 1. An adsorption complex , comprising: 1-methyl cyclopropane (1-MCP); and a metal coordination polymer network (MCPN) , comprising a metal node selected from Mg , Mn , Ca , Cu , Al , Zn , Fe , Co , or a combination thereof , and one or more ligands coupled to the metal node.2. The adsorption complex of claim 1 , wherein the one or more ligands comprise one or more carboxylate groups.3. The adsorption complex of claim 1 , wherein the one or more ligands are selected from an amino acid or citric acid.4. The adsorption complex of claim 1 , wherein the one or more ligands are selected from 2 claim 1 ,4 claim 1 ,6-tris(3 claim 1 ,5-dicarboxylphenylamino)-1 claim 1 ,3 claim 1 ,5-triazine claim 1 , biphenyldicarboxylate claim 1 , 4 claim 1 ,4′-bipyridine claim 1 , 1 claim 1 ,2-bipyridylethene claim 1 , O(O)C—C—H—C(O)O— claim 1 , formate claim 1 , terephthalate claim 1 , benzene-1 claim 1 ,3 claim 1 ,5-tricarboxylate claim 1 , 2-methylimidazole claim 1 , fumarate claim 1 , —OH claim 1 , a reaction product of tetra-(4-bromo-phenyl)ethylene and 4-(methoxycarbonyl) phenylboronic acid claim 1 , 4 claim 1 ,4′-sulfonyldibenzoate claim 1 , or a combination thereof.5. The adsorption complex of claim 1 , wherein the MCPN has a mean pore diameter of 1 to 50 Å.6. The adsorption complex of claim 1 , wherein the MCPN is a magnesium coordination polymer network or a calcium coordination polymer network.7. The adsorption complex of claim 1 , wherein the MCPN is Co(biphenyldicarboxylate)34 claim 1 ,4′bipyridine].4DMF.HO or [Co ...

POLYMERS PREPARED FROM MEVALONOLACTONE AND DERIVATIVES

Described herein polymer precursor compounds (aka polymer building blocks) of derived from biobased compounds, and specifically biobased mevalonolactone and its related derivatives. Through oxidation these biobased precursors can be reacted to yield building blocks for (unsaturated-) polyesters, polyester polyols and polyamides, as well as precursors for glycidyl esters and omega-alkenyl esters. Through reduction, these biobased precursors can be reacted to yield building blocks for (unsaturated-) polyesters, polyester polyols, polycarbonates, as well as precursors for glycidyl ethers and omega-alkenyl ethers. Through nucleophilic ring opening and/or amidation, these biobased precursors can be reacted to yield building blocks for polyester polyols, chain-extender for polyurethanes, or polyester-amides. 2. The compound of claim 1 , wherein each Ris selected from the group consisting of C-Calkyls.3. The compound of claim 1 , wherein said compound being selected from the group consisting of Formula (XXVb) claim 1 , Formula (XXVc) claim 1 , Formula (XXVd) claim 1 , Formula (XXVe) claim 1 , Formula (XXVf) claim 1 , and combinations thereof4. The compound of claim 1 , wherein said compound being selected from the group consisting of Formula (XXVd) claim 1 , Formula (XXVe) claim 1 , Formula (XXVf) claim 1 , and combinations thereof5. The compound of claim 1 , wherein said compound being selected from the group consisting of Formula (XXVa) claim 1 , Formula (XXVb) claim 1 , Formula (XXVc) claim 1 , and combinations thereof.6. The compound of claim 1 , wherein said compound is Formula (XXVb).7. The compound of claim 1 , wherein said compound is Formula (XXVc).8. The compound of claim 1 , wherein said compound is Formula (XXVd).9. The compound of claim 1 , wherein said compound is Formula (XXVe).10. The compound of claim 1 , wherein said compound is Formula (XXVf).12. The compound of claim 11 , wherein each Ris selected from the group consisting of C-Calkyls.13. The compound ...

Process for preparing di-substituted succinates

The invention relates to a process for preparing (2,3) disubstituted succinates that allows (2,3) disubstituted succinates to be obtained in good purity and with acceptable reaction yields. The (2) and (3) substitutions may be the same or different. The process comprises reacting a haloacetate with a malonic acid ester into a tricarboxylate, which is further reacted to a (2,3) disubstituted tricarboxylate, hydrolyzed, decarboxylated and optionally esterified. Esterified (2,3) disubstituted succinic esters may be used as internal donor in Ziegler-Natta type catalysts for the polymerization of olefins.

Ashless mannich despersants, their preparation, and their use

Ashless dispersants are formed using polymers of propylene characterized in that they are liquid substantially linear polymers, they have stereo-irregularity in the polymer chain, at least 60 mol percent of the polymer has a terminal vinylidene group and, optionally, the polymer contains up to 25 mol percent of ethylene or a C 4 to C 10 monoolefin polymerized into the polymer chains.

펩티딜(peptidyl) 유도체

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一种无氟烷基羧酸离子液体及其制备方法和应用

本发明提供了一种无氟烷基羧酸离子液体，具有如下通式(I)所示结构，其中：R 1 -R 4 分别独立选自碳原子数为1-18的烷基，或者苄基；R 5 选自碳原子数为1-6的烷基，或者通式(II)所示的基团，n选自2-12之间的任意整数。本发明提供的无氟烷基羧酸离子液体由于所采用的原料为低毒、廉价的季铵盐和脂肪酸钠盐，因此合成成本低、毒性小；由于不含氟元素，因此水解稳定性高，避免对金属基底材料造成腐蚀，是一种绿色环保的液体润滑剂，可作为钢/钢、钢/铜和钢/铝摩擦副的润滑剂，具有优异的减摩抗磨性能。

Quaternary ammonium compounds as additives to fuel or lubricants

FIELD: machine building. SUBSTANCE: invention relates to a novel diesel fuel composition which contains as an additive one or more quaternary ammonium compounds of formula (X) , (X'), where each of R 0 , R 1 , R 2 and R 3 independently represents C 1 -C 6 alkyl group optionally substituted with a hydroxy group and/or alkoxy group, and A is CHRCH 2 , where R is a polyisobutenyl group having a molecular weight of 260 to 1000, or C 10 -C 24 alkyl or alkenyl group. Preferably, the composition contains a quaternary ammonium compound (X'), where each of R 1 , R 2 and R 3 and A have values given above, each of R 4 , R 5 , R 6 and R 7 is independently selected from hydrogen or alkyl group, optionally substituted with hydroxy group and/or alkoxy group. Compound (X) can be a reaction product of (a) a tertiary amine of formula R 1 R 2 R 3 N, molecular weight of which is less than 1000; (b) epoxide of formula ; and (c) a diacid of formula HOOCCHRCH 2 COOH, where R is a polyisobutenyl group having a molecular weight of 260 to 1000, or C 10 -C 24 alkyl group, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 and R 7 have values given above. Invention also relates to a method of improving operational characteristics of a diesel engine by burning said composition in an engine. Engine represents a diesel engine with a fuel injection system, which includes a high pressure fuel injection system (HPFI), in which fuel pressure exceeds 1350 bar (1.35⋅10 8 Pa). Use of additive counteracts formation of deposits in engine, in particular formation of internal deposits in injectors of diesel engine and external deposits on nozzles of diesel engine, including deposits on injector nozzle and deposits on nozzle tip, and also formation of deposits on fuel filter. Use of the additive in the composition also helps to maintain purity or purification of the engine. EFFECT: use of fuel with the proposed additive in comparison with the known additive leads to increase of torque and increases average flow ...

Method for producing diamine salt, diamine salt solution, diamine salt and polymer

本发明提供了一种二元酸胺盐的制备方法、二元酸胺盐溶液、二元酸胺盐和聚合得到的聚合物。所述二元酸胺盐的制备方法包括：将含有1，5‑戊二胺盐的混合物和含有二元酸盐的混合物分别通入所述电渗析装置的淡化室，两个淡化室间隔排列，从连通所述电渗析装置的浓缩室的部分浓缩管中得到纯化的二元酸胺盐溶液。本发明直接针对含有多种杂质、体系复杂的、含有1.5‑戊二胺盐的混合物和含有二元酸盐的混合物，通过电渗析处理，能够有效降低产品二元酸胺盐中杂质含量和色度。电渗析后的无机酸盐可以套用到下一次发酵过程，原子利用率高。本发明有效解决了现有技术中聚合级二元酸和聚合级胺单体的制备、提纯过程复杂，成本高、收率低的问题。

Preparation of difunctional compounds

Salt of monocyclic pyridine derivative and crystal thereof

본 발명은 약제를 위한 벌크 물질로서 사용될 수 있는, 숙신산 및 말레산으로 이루어진 군으로부터 선택된 유기카복실산 및 하기 화학식 (I)로 표현되는 화합물로 이루어진 염, 및 이의 결정을 제공한다: [화학식 I]

Chemical compositions and methods of making them

Reaction products of polyfunctional compounds with two or more coordination elements are described.

Salt of monocyclic derivative of pyridine and crystal thereof

FIELD: chemistry. SUBSTANCE: invention relates to salts consisting of succinic acid and maleic acid and a compound represented by the formula (I) . Invention also relates to crystals thereof and a pharmaceutical composition based thereon. EFFECT: obtaining novel compounds that can be used in medicine to treat cancer. 15 cl, 3 tbl, 15 dwg, 6 ex РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 2 658 821 C1 (51) МПК C07D 401/14 (2006.01) A61K 31/4545 (2006.01) A61P 35/00 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ОПИСАНИЕ ИЗОБРЕТЕНИЯ К ПАТЕНТУ (52) СПК C07D 401/14 (2006.01); A61K 31/4545 (2006.01) (21)(22) Заявка: 2017103439, 17.08.2015 (24) Дата начала отсчета срока действия патента: (73) Патентообладатель(и): ЭЙСАЙ Ар ЭНД Ди МЕНЕДЖМЕНТ КО., ЛТД. (JP) Дата регистрации: 25.06.2018 (56) Список документов, цитированных в отчете о поиске: RU 2005108999 А, 27.08.2005. WO 18.08.2014 JP 2014-166118 2013/010380 A1, 24.01.2013. EP 1415987 A1, 06.05.2004. (45) Опубликовано: 25.06.2018 Бюл. № 18 (85) Дата начала рассмотрения заявки PCT на национальной фазе: 02.02.2017 (86) Заявка PCT: WO 2016/027781 (25.02.2016) Адрес для переписки: 129090, Москва, ул. Б. Спасская, 25, стр. 3, ООО "Юридическая фирма Городисский и Партнеры" (54) СОЛЬ МОНОЦИКЛИЧЕСКОГО ПРОИЗВОДНОГО ПИРИДИНА И ЕЕ КРИСТАЛЛ (57) Реферат: Изобретение относится к солям, состоящим Изобретение также относится к их кристаллам из янтарной кислоты и малеиновой кислоты, и и фармацевтической композиции на их основе. соединения, представленного формулой (I) Технический результат: получены новые соединения, которые могут найти свое применение в медицине для лечения рака. 9 н. и 6 з.п. ф-лы, 3 табл., 15 ил., 6 пр. R U 2 6 5 8 8 2 1 (87) Публикация заявки PCT: Стр.: 1 C 1 C 1 JP 2015/073047 (17.08.2015) 2 6 5 8 8 2 1 Приоритет(ы): (30) Конвенционный приоритет: R U 17.08.2015 (72) Автор(ы): ОДЗАКИ Сунсуке (JP), ЙОСИДА Кенси (JP) RUSSIAN FEDERATION (19) RU (11) (13) 2 658 821 C1 (51) Int. Cl. C07D 401/14 (2006.01) ...

Quaternary ammonium compounds as fuel or lubricant additives

(a) 1000 미만의 분자량을 갖는 3급 아민; (b) 산-활성화된 알킬화제; 및 (c) 적어도 5개의 탄소 원자를 갖는 임의로 치환된 히드로카르빌 모이어티를 포함하는 이산의 반응 생성물인 4급 암모늄 화합물이 제공된다. (a) a tertiary amine having a molecular weight of less than 1000; (b) acid-activated alkylating agents; and (c) a diacid comprising an optionally substituted hydrocarbyl moiety having at least 5 carbon atoms.

Electrolyte for electrolytic capacitor and electrolytic capacitor using the same

다음 일반식(I) 또는 (II)로 표시되는 3급 디카르복실산의 염을 함유함을 특징으로하는 전해 콘덴서용 전해액: An electrolytic solution for an electrolytic capacitor, comprising a salt of a tertiary dicarboxylic acid represented by the following general formula (I) or (II): (식중 n은 1 내지 5의 정수이고, R 1 내지 R 4 는 탄소수 4이하인 알킬기임) Wherein n is an integer of 1 to 5 and R 1 to R 4 are alkyl groups having 4 or less carbon atoms. (식중 n은 상기 정의한 바와 같고, ℓ및 m은 각각 정수 4 또는 5를 나타내며, R 5 및 R 6 은 각각 수소원자, 메틸기 또는 에틸기를 표시한다) (Wherein n is as defined above, l and m each represent an integer of 4 or 5, and R 5 and R 6 each represent a hydrogen atom, a methyl group or an ethyl group) 및 이를 이용한 전해 콘덴서가 개시된다. And an electrolytic capacitor using the same.

Acrylamide Compounds as Histamine H3 Receptor Ligands

본 발명은 하기 일반식 (I)의 신규한 아크릴아미드 화합물 및 이의 약제학적으로 허용가능한 염, 및 이들의 제조방법에 관한 것이다. 일반식 (I)의 화합물은 히스타민 H 3 수용체와 관련된 각종 장애의 치료에 유용하다. The present invention relates to novel acrylamide compounds of the general formula (I), their pharmaceutically acceptable salts, and processes for their preparation. A compound represented by the general formula (I) are useful in the treatment of various disorders related to the histamine H 3 receptor.

Salt crystal

本发明涉及盐晶体，特别涉及(6aR,9aS)‑5,6a,7,8,9,9a‑六氢‑5‑甲基‑3‑(苯基氨基)‑2‑((4‑(6‑氟吡啶‑2‑基)苯基)甲基)‑环戊二烯并[4,5]咪唑并[1,2‑a]吡唑并[4,3‑e]嘧啶‑4(2H)‑酮的酸加成盐和盐晶体，包含其的组合物以及制备和使用所述盐和晶体的方法。

Epidermal growth factor receptor kinase inhibitor salts.

Buluş, EGFR kinazların inhibitörü olarak yararlı ve bunlar için arzu edilen özellikler sergileyen tuz formları ve bunların bileşimlerini sağlamaktadır. The invention provides salt forms and compositions thereof which are useful as inhibitors of EGFR kinases and exhibit desirable properties therefor.

Patent RU2016104250A3

ВИ“? 2016104250” АЗ Дата публикации: 25.04.2018 Форма № 18 ИЗПМ-2011 Федеральная служба по интеллектуальной собственности Федеральное государственное бюджетное учреждение 5 «Федеральный институт промышленной собственности» (ФИПС) ОТЧЕТ О ПОИСКЕ 1. . ИДЕНТИФИКАЦИЯ ЗАЯВКИ Регистрационный номер Дата подачи 2016104250/04(006762) 28.07.2014 РСТ/СВ2014/052311 28.07.2014 Приоритет установлен по дате: [ ] подачи заявки [ ] поступления дополнительных материалов от к ранее поданной заявке № [ ] приоритета по первоначальной заявке № из которой данная заявка выделена [ ] подачи первоначальной заявки № из которой данная заявка выделена [ ] подачи ранее поданной заявки № [Х] подачи первой(ых) заявки(ок) в государстве-участнике Парижской конвенции (31) Номер первой(ых) заявки(ок) (32) Дата подачи первой(ых) заявки(ок) (33) Код страны 1. 1313423.4 26.07.2013 СВ Название изобретения (полезной модели): [Х] - как заявлено; [ ] - уточненное (см. Примечания) ЧЕТВЕРТИЧНЫЕ АММОНИЕВЫЕ СОЕДИНЕНИЯ В КАЧЕСТВЕ ДОБАВОК К ТОПЛИВУ ИЛИ СМАЗОЧНЫМ МАТЕРИАЛАМ Заявитель: ИННОСПЕК ЛИМИТЕД, СВ 2. ЕДИНСТВО ИЗОБРЕТЕНИЯ [Х] соблюдено [ ] не соблюдено. Пояснения: см. Примечания 3. ФОРМУЛА ИЗОБРЕТЕНИЯ: [Х] приняты во внимание все пункты (см. Примечания) [ ] приняты во внимание следующие пункты: [ ] принята во внимание измененная формула изобретения (см. Примечания) 4. КЛАССИФИКАЦИЯ ОБЪЕКТА ИЗОБРЕТЕНИЯ (ПОЛЕЗНОЙ МОДЕЛИ) (Указываются индексы МПК и индикатор текущей версии) С07С 211/62 (2006.01) С 1ОГ. 1/188 (2006.01) СТОМ 133/04 (2006.01) С1ОГ. 1/232 (2006.01) С 10Г. 10/06 (2006.01) С1ОГ. 1/222 (2006.01) С 10Г. 10/18 (2006.01) 5. ОБЛАСТЬ ПОИСКА 5.1 Проверенный минимум документации РСТ (указывается индексами МПК) С07С 211/62, СЛОТ, 1/232, СЛОТ, 1/222, СТОГ, 1/188, СЛОГ, 10/06, СТОГ, 10/18, С1ОМ 133/04 5.2 Другая проверенная документация в той мере, в какой она включена в поисковые подборки: 5.3 Электронные базы данных, использованные при поиске (название базы, и если, возможно, поисковые термины): СТРО, РЕРАТБ ...

Dicarboxylic acids production process

FIELD: industrial organic synthesis. SUBSTANCE: invention relates to improved process for production of dicarboxylic acids useful for various applications, for example as additive to various products, in manufacture of concrete, as well as monomers in polymer production. Process consists of oxidizing cyclohexane with oxygen or oxygen-containing gas in presence of oxidation catalyst and lipophilic-type oxidation solvent. Process comprises stage of extraction of dicarboxylic acids formed in oxidation stage, which extraction stage consisting in performing liquid-phase extraction of diatomic acids with the aid of first extraction solvent, wherein at least oxidation solvent and cyclohexane are insoluble, said extraction being carried out in countercurrent liquid-liquid extraction column. EFFECT: enhanced process efficiency due to efficient diacid extraction stage and complete oxidation solvent recycling. 15 cl, 2 ex ÐÎÑÑÈÉÑÊÀß ÔÅÄÅÐÀÖÈß RU (19) (11) 2 296 742 (13) C2 (51) ÌÏÊ C07C C07C C07C C07C 51/31 51/09 55/14 55/02 (2006.01) (2006.01) (2006.01) (2006.01) ÔÅÄÅÐÀËÜÍÀß ÑËÓÆÁÀ ÏÎ ÈÍÒÅËËÅÊÒÓÀËÜÍÎÉ ÑÎÁÑÒÂÅÍÍÎÑÒÈ, ÏÀÒÅÍÒÀÌ È ÒÎÂÀÐÍÛÌ ÇÍÀÊÀÌ (12) ÎÏÈÑÀÍÈÅ ÈÇÎÁÐÅÒÅÍÈß Ê ÏÀÒÅÍÒÓ (21), (22) Çà âêà: 2005116245/04, 28.10.2003 (24) Äàòà íà÷àëà îòñ÷åòà ñðîêà äåéñòâè ïàòåíòà: 28.10.2003 (30) Êîíâåíöèîííûé ïðèîðèòåò: 30.10.2002 FR 02 13579 (73) Ïàòåíòîîáëàäàòåëü(è): ÐÎÄÈÀ ÏÎËÈÀÌÈÄ ÈÍÒÅÐÌÅÄÈÝÉÒÑ (FR) (43) Äàòà ïóáëèêàöèè çà âêè: 27.01.2006 R U (72) Àâòîð(û): ÁÎÍÍÅ Äèäüå (FR), ÀÌÎÐÎ Äàíèåëü (FR), ÑÈÌÎÍÀÒÎ Æàí-Ïüåð (FR), ÎÆÜÅ Ôðåäåðèê (FR), ÁÐÎÃËÈÎ Ìàðèà-Èíüåñ (FR) (45) Îïóáëèêîâàíî: 10.04.2007 Áþë. ¹ 10 2 2 9 6 7 4 2 (56) Ñïèñîê äîêóìåíòîâ, öèòèðîâàííûõ â îò÷åòå î ïîèñêå: FR 2806079 A, 14.09.2001. US 4032569 À, 28.06.1977. GB 820518 À, 23.09.1959. US 2916502 À, 08.12.1959. SU 806670 À, 25.02.1981. (85) Äàòà ïåðåâîäà çà âêè PCT íà íàöèîíàëüíóþ ôàçó: 30.05.2005 2 2 9 6 7 4 2 R U (87) Ïóáëèêàöè PCT: WO 2004/041768 (21.05.2004) C 2 C 2 (86) Çà âêà PCT: FR 03/03196 (28.10.2003) Àäðåñ äë ...

METHOD FOR MANUFACTURING A SOLUTION OF DIACID / DIAMINE SALTS

La présente invention concerne un procédé de fabrication d'une solution d'un sel de diamine et de diacide pour la fabrication de polyamide.L'invention concerne, plus particulièrement, un procédé pour la fabrication d'un d'une solution concentrée en sel adipate d'hexaméthylène diammonium, appelé également sel Nylon, utilisée comme matière première pour la fabrication de polyamide, plus précisément de PA66. Le procédé de fabrication de solution aqueuse de sels de diamines et diacides obtenus par mélange d'un diacide et d'une diamine, à une concentration pondérale en sel comprise entre 50 et 80%, consiste à réaliser dans une première étape une solution aqueuse de diacide et diamine présentant un rapport molaire diacide/diamine supérieur à 1,1 et dans une deuxième étape à ajuster le rapport molaire diacide/diamine par addition de diamine à une valeur comprise entre 0,9 et 1,1, de préférence entre 0,99 et 1,01, et à fixer la concentration pondérale en sel par, éventuellement, addition d'eau. The present invention relates to a process for producing a solution of a diamine and diacid salt for the manufacture of polyamide. The invention relates, more particularly, to a process for the production of a concentrated salt solution. hexamethylene diammonium adipate, also called nylon salt, used as a raw material for the manufacture of polyamide, more specifically PA66. The process for producing an aqueous solution of diamine and diacid salts obtained by mixing a diacid and a diamine, at a salt concentration by weight of between 50 and 80%, consists in producing, in a first step, an aqueous solution of diacid and diamine having a diacid / diamine molar ratio greater than 1.1 and in a second step to adjust the diacid / diamine molar ratio by adding diamine to a value between 0.9 and 1.1, preferably between 0, 99 and 1.01, and to fix the weight concentration of salt by, optionally, addition of water.

Advanced processes for the preparation of nitroacetates and nitrocetones

Patent FR3124M

Lithium dicarboxylic acid salts - in compositions for treatment of psychoses, esp. manic depression

Method of producing aqueous salt solution

Изобретение относится к усовершенствованному способу непрерывного получения раствора солей, в частности получения адипата гексаметилендиамина, и к устройству для осуществления такого способа. Способ непрерывного получения водного раствора солей осуществляют путем проведения реакции алкандикарбоновых кислот с 6-12 атомами углерода и алкандиаминов с 6-12 атомами углерода с проведением следующих стадий: a) определенное количество алкандикарбоновой кислоты в виде твердого вещества дозируют в первый реактор через по меньшей мере одну первую точку подачи, и субстехиометрическое количество неразбавленного алкандиамина дозируют в по меньшей мере одной второй точке подачи, а также одновременно дозируют воду в по меньшей мере одной третьей точке подачи первого реактора для получения в реакторе водного раствора соли, где стехиометрическое отношение алкандикарбоновой кислоты к алкандиамину в первом реакторе составляет от 1:0,95 до 1:0,99; b) полученный раствор соли непрерывно переносят в последовательно присоединенный второй реактор и c) во втором реакторе проводят подпитку алкандиамина, при этом стехиометрические отношения в первом и втором реакторах регулируют путем измерения значения рН при постоянной температуре. Устройство для непрерывного получения водного раствора солей включает: a) первый реактор (1), оборудованный нагревающей или охлаждающей рубашкой, или нагревающим или охлаждающим устройством, предназначенный для проведения реакции алкандикарбоновых кислот с алкандиамином, при этом первый реактор (1) имеет по меньшей мере одну первую точку (4) подачи для алкандикарбоновых кислот, по меньшей мере одну вторую точку (5) подачи для алкандиамина и по меньшей мере одну третью точку (6) подачи для воды, b) второй реактор (2), оборудованный нагревающей или охлаждающей рубашкой, или нагревающим или охлаждающим устройством, который соединен с первым реактором (1) и который имеет по меньшей мере одну дополнительную точку (10) подачи для алкандиамина, а также c) измерительные ...

Hydraulic fluid compositions

Preparation of polar organic compounds

Compounds of formual: Z1-A-Z2 (where Z2 = -COOH, COOR4, -OH, -OCOR4, -CHO, -CH(OR4)2, -COR4, -CN, R4 = low alkyl group of 1-4 C, Z1 = Z2, H or phenyl radical and A = divalent hydrocarbon residue of 8-38 C) are prepd. by reaction between ozone, a compound of formula : R1CH=CHCH2R2Z (where R1 = CH3 or H, R2 = divalent hydrocarbon residue of 3-18 C and Z = Z1) and compounds of formula: CH = CX - R3 (where R3 = divalent saturated hydrocarbon residue of 3-18 C or a group of formula: -CH2CH(CH=CHCH2CH2)n where n = 1 or 2 and X = H, R4O- or R4COO-) to give a product which is treated with a redox reducer in the presence of an organic solvent and absence of Cl-, Br-, I-, CN-, SCN-, N3-, S2O3 = or SO3 = anions).

Improved process for the preparation of metallo-derivatives using alkali metals

Patent FR2244485B1

Substituted 4-biarylbutyric or 5-byarylpentanic acids or derivatives thereof, methods of preparation thereof, pharmaceutical composition, and method of medical treatment

FIELD: medicine. SUBSTANCE: described are new substituted 4-biarylbutyric or 5-biarylpentanic acids or derivatives thereof of general formula: (T) x A-B-D-E-G wherein (T) x A,B,D,E,G are as defined in claim 1. Said compounds are capable of inhibiting matrix metalloprotease. Also described are method of preparation of said compounds, pharmaceutical composition based thereon and method of medical treatment. EFFECT: improved properties of the title compounds. 28 cl, 3 dwg, 429 ex ГэЭресбс ПЧ сэ РОССИЙСКОЕ АГЕНТСТВО ПО ПАТЕНТАМ И ТОВАРНЫМ ЗНАКАМ ВО ”” 2 159 761 ' (51) МПК? 13) С2 С 07С 59/88, 59/48, 59/68, 59/90, С 07 0 213/00, 333/00, А 61 К 31/19 12) ОПИСАНИЕ ИЗОБРЕТЕНИЯ К ПАТЕНТУ РОССИЙСКОЙ ФЕДЕРАЦИИ (21), (22) Заявка: 97110108/04, 09.11.1995 (24) Дата начала действия патента: 09.11.1995 (30) Приоритет: 15.11.1994 Ц$ 08/339846 (46) Дата публикации: 21.11.2000 (56) Ссылки: ЕР 046879 АЛ, 15.01.1992. ЕР 0180290 АЛ, 07.05.1986. Ц$ 0182061 А, 04.05.1965. СВ 1565616 А, 23.04.1980. ЕК 2503140 А, 08.10.1982. ЗЦ 519130 А, 25.06.1976. ЗИ 1524809 АЗ, 23.11.1989. Машковский М.Д. "Лекарственные средства", М., Медицина, т.1, с.130. 4$ 5190937 А, 02.03.1993. МО 9519965 А, 27.07.1995. (85) Дата перевода заявки РСТ на национальную фазу: 16.06.1997 (86) Заявка РСТ: 1$ 95/14002 (09.11.1995) (87) Публикация РСТ: М/О 96/15096 (23.05.1996) (98) Адрес для переписки: 129010, Москва, ул. Большая Спасская 25, стр.3, ООО "Городисский и Партнеры", Лебедевой Н.Г. (71) (72) (73) Заявитель: . БАИЕР КОРПОРЕИШН (1$) Изобретатель: Харольд Клинтон Юджен КЛЮЭНДЕР (13), Гюнтер Ханс Хайнц Херберт БЕНЦ (ОЕ), Дэвид Росс БРИТТЕЛЛИ (4$), Уилльям Харрисон БАЛЛОК (4$), Керри Жанн КОУМЗ (0$), Брайан Ричард ДИКСОН (4$), Стефан ШНАЙДЕР (ОЕ), Джилл Элизабет ВУД (0$), Майкл Кристофер ВАНЗАНДТ (0$), Дональд Джон ВОЛАНИН (1$), Скотт М. ВИЛЬГЕЛЬМ (43) Патентообладатель: БАЙЕР КОРПОРЕЙШН (1$) (54) ЗАМЕЩЕННЫЕ 4-БИАРИЛМАСЛЯНЫЕ ИЛИ 5-БИАРИЛПЕНТАНОВЫЕ КИСЛОТЫ ИЛИ ИХ ПРОИЗВОДНЫЕ, СПОСОБЫ ИХ ПОЛУЧЕНИЯ, ФАРМАЦЕВТИЧЕСКАЯ ...

Salts of epidermal growth factor receptor kinase inhibitors

本发明提供一种盐形式和其组合物，其用作EGFR激酶的抑制剂并且其展现所述抑制剂的所需特征。

POLYCARBOXYLIC ACID / AMINE SALTS, AQUEOUS SYSTEM CONTAINING THEM AND METHOD FOR INHIBITING CORROSION OF METALS

L'INVENTION CONCERNE DES INHIBITEURS UTILES POUR EMPECHER LA CORROSION DE SURFACES METALLIQUES QUI VIENNENT EN CONTACT AVEC DES SYSTEMES AQUEUX LES CONTENANT. ILS COMPRENNENT DES SELS D'ACIDES POLYCARBOXYLIQUES ET DE MONOAMINES. DES INHIBITEURS DE CORROSION TYPIQUES SONT PREPARES A PARTIR D'ACIDES TELS QUE LES ACIDES SEBACIQUE ET AZELAIQUE ET DE MONOAMINES TELLES QUE L'ETHANOLAMINE, LA DI- ET LA TRI-ETHANOLAMINE ET LA N,N-DIETHYL-ETHANOLAMINE. THE INVENTION RELATES TO USEFUL INHIBITORS FOR PREVENTING CORROSION OF METAL SURFACES WHICH COME IN CONTACT WITH AQUEOUS SYSTEMS CONTAINING THEM. THEY CONTAIN SALTS OF POLYCARBOXYLIC ACIDS AND MONOAMINES. TYPICAL CORROSION INHIBITORS ARE PREPARED FROM ACIDS SUCH AS SEBACIC AND AZELAIC ACIDS AND MONOAMINES SUCH AS ETHANOLAMINE, DI- AND TRI-ETHANOLAMINE AND N, N-DIETHYL-ETHANOLAMINE.

Synthesis of alpha-methylene carboxylic acid esters from allene, carbon monoxide, and an alcohol with iron or ruthenium carbonyl catalysts

Fatty oil acid ester

Quaternary ammonium compounds as fuel or lubricant additives

하기 화학식 X의 4급 암모늄 화합물이 제공된다: <화학식 X> 상기 식에서, R 0 , R, R 2 및 R 3 은 각각 독립적으로 임의로 치환된 알킬, 알케닐 또는 아릴 기이고, R은 적어도 5개의 탄소 원자를 갖는 임의로 치환된 히드로카르빌 모이어티를 포함하는 포함한다. Quaternary ammonium compounds of formula (X) are provided: <Formula X> wherein R 0 , R , R 2 and R 3 are each independently an optionally substituted alkyl, alkenyl or aryl group, wherein R comprises an optionally substituted hydrocarbyl moiety having at least 5 carbon atoms. do.

Branched fluorine-containing compound

A novel branched fluorine-containing compound represented by formula (1):(Rf—Yn1LX-A)n2  (1)wherein L represents a predetermined carbon-containing linker moiety; Rf, in each occurrence, is the same or different and represents fluoroalkyl optionally having at least one ether bond; Y, in each occurrence, is the same or different and represents a predetermined divalent linking group or a bond; RY, in each occurrence, is the same or different and represents hydrogen or an organic group; L represents an (n1+n2)-valent carbon-containing linker moiety having at least one carbon atom; n1 represents a number greater than or equal to 1; n2 represents a number greater than or equal to 1; n1+n2 is a number from 3 to 6; X, in each occurrence, is the same or different and represents a divalent linking group or a bond; A, in each occurrence, is the same or different and represents —ArSO3M or the like; M, in each occurrence, is the same or different and represents hydrogen, —NR4, or a metal salt; and R represents hydrogen or a C1-4 organic group.

Process for converting nitrile compounds to carboxylic acids and corresponding esters

The present invention relates to a process for converting hydrocarbon-based compounds comprising at least one nitrile function to compounds comprising at least one carboxylic function, and also to a process for obtaining ester compounds from the resulting carboxylic compounds. The process comprises reacting the nitrile compound with a basic hydroxyl compound in solution in a solvent at a temperature of 80 to 200°C, removing the ammonia formed, reacting the resulting salt with an inorganic acid and then recovering the compound comprising at least one carboxylic function and, optionally, esterifying the resulting acids by reacting same with an alcohol.

METHOD FOR MANUFACTURING A SOLUTION OF DIACID / DIAMINE SALTS

Aliphatic materials and uses thereof in heating and cooling applications

Aliphatic materials and their use in passive heating and cooling applications are generally disclosed. In some embodiments, dibasic acids and esters (diesters) thereof and their use in passive heating and cooling applications are disclosed. In some embodiments, C 18 dibasic acids and esters thereof are disclosed, including their use in passive heating and cooling applications. In some embodiments, various olefins, including alkenes and olefinic acids and esters, are disclosed, including their use in passive heating and cooling applications.

Purification of polycarboxylic acids

A process for purifying a polycarboxylic acid from a mixture is provided. Optionally, the mixture is an aqueous solution and optionally the process comprises an acidification step and/or the use of one or more organic solvents. Also provided in part are compositions of polycarboxylic acids.

Preparation of dicarboxylic acids by oxidation, with oxygen or an oxygen-containing gas, of a cycloaliphatic hydrocarbon in the presence of a catalyst and a lipophilic monocarboxylic acid

Process for the preparation of a dicarboxylic acid from a cycloaliphatic hydrocarbon by oxidation with oxygen or an oxygen-containing gas in the presence of a catalyst and a lipophilic solvent. It comprises an extraction stage of dicarboxylic acids by liquid phase extraction using a primary extraction solvent in which the oxidation solvent and cycloaliphatic hydrocarbon are not soluble.

Copper complexes, their preparation, their use in controlling plant pests, and agents for such control

ABSTRACT OF THE DISCLOSURE A pesticidal composition containing a plant-tolerated copper ammino salt of a polycarboxylic acid, wherein the acid is a coploymer of 60 to 100% of acrylic acid or methacrylic acid and 0 to 40% of an acrylic acid ester or methacrylic acid ester.

Metal salts of alkenyl succinic acid

Quaternary ammonium compounds as fuel or lubricant additives

A quaternary ammonium compound of formula (X), wherein R

PROCESS FOR THE TRANSFORMATION OF NITRILIC COMPOUNDS OF CARBOXYLIC ACIDS AND CORRESPONDING ESTERS

Saturated biaribultiric or 5-biaripentanoic acids and derivatives as inhibitors of metalloprotease matrices