23-01-2014 дата публикации
Номер: US20140024842A1
The invention discloses a method for the preparation of tert-butyl 6-chloro-3,5-dioxohexanoate from Meldrum's acid derivative and its use for the preparation of tert-butyl(4R,65)-(6-hydroxymethyl-2,2-dimethyl-1,3-dioxan-4-yl)acetate (BHA), Rosuvastatin and Atorvastatin. 120-. (canceled)22. Method (B) according to claim 21 , wherein R1-IV and R3 are identical and are Cl or Br.23. Method (B) according to claim 21 , wherein base (B) is selected from the group consisting of N(R4)(R5)R6 claim 21 , 1 claim 21 ,4-diazabicyclo[2.2.2]octane claim 21 , a hexamethyldisilazide claim 21 , a Calkoxide salt of claim 21 , a Ccarboxylate salt of claim 21 , a carbonate salt of claim 21 , a hydrogen carbonate salt of claim 21 , a phosphate salt of claim 21 , a monohydrogenphosphate salt of or a dihydrogenphosphate salt of Na claim 21 , of K or of Li claim 21 , 1 claim 21 ,8-diazabicyclo[5.4.0]undec-7-ene claim 21 , NaNH claim 21 , KNH claim 21 , NaH claim 21 , KH claim 21 , CaH claim 21 , pyridine claim 21 , pyridine substituted with 1 or 2 independently selected identical or different Calkyl residues claim 21 , N claim 21 ,N-dimethyl-4-pyridinamine claim 21 , morpholine claim 21 , 4-methylmorpholine claim 21 , 1-methylpiperidine claim 21 , imidazol claim 21 , benzimidazol claim 21 , 2-methylimidazole claim 21 , 4-methylimidazole claim 21 , 2-ethylimidazole claim 21 , 2-ethyl-4-methylimidazole claim 21 , 2-isopropylimidazole claim 21 , 2-phenylimidazole claim 21 , 4-phenylimidazole claim 21 , picoline claim 21 , CsCO claim 21 , NaOH claim 21 , KOH claim 21 , Ca(OH)and mixtures thereof; with R4 claim 21 , R5 and R6 as defined in .24. Method (B) according to claim 21 , wherein R4 claim 21 , R5 claim 21 , R6 are identical or different and independently from each other selected from the group consisting of cyclohexyl claim 21 , phenyl claim 21 , methyl claim 21 , ethyl claim 21 , n-propyl claim 21 , iso-propyl claim 21 , n-butyl claim 21 , iso-butyl claim 21 , sec-butyl claim 21 , tert- ...
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