СПОСОБ ПОЛУЧЕНИЯ КАТАЛИЗАТОРА НА ОСНОВЕ ОКСИДА АЛЮМИНИЯ И ЕГО ПРИМЕНЕНИЕ (ВАРИАНТЫ)

... 1. Способ получения катализатора, включающего оксид алюминия, пропитанный основанием, которое выбирают из гидроксидов щелочных металлов, отличающийся тем, что проводят обработку водного раствора гидроксида щелочного металла оксидом алюминия в органическом растворителе и высушивают полученную смесь катализатора при температуре менее 150°С. 2. Способ по п.1, отличающийся тем, что органический растворитель выбирают из группы, включающей дихлорметан, диоксан, толуол, ацетонитрил или диметилформамид (ДМФ). 3. Применение катализатора, полученного по п.1, в качестве средства для введения защитных групп. 4. Применение по п.3 для введения защитных групп в амины, представляющие собой первичные или вторичные амины, выбранные из ряда, включающего ароматические, алифатические, гетероциклические или циклические амины. 5. Применение по п.3 для введения защитных групп в тиолы, представляющие собой первичные, вторичные или третичные тиолы, выбранные из ряда, включающего ароматические, алифатические, гетероциклические ...

СПОСОБ ПОЛУЧЕНИЯ ДИАРИЛКАРБОНАТА И ПЕРЕРАБОТКА, ПО МЕНЬШЕЙ МЕРЕ, ОДНОЙ ЧАСТИ ОБРАЗОВАННОГО ПРИ ЭТОМ РАСТВОРА, СОДЕРЖАЩЕГО ХЛОРИД ЩЕЛОЧНЫХ МЕТАЛЛОВ, В НАХОДЯЩЕМСЯ НИЖЕ ПО ТЕХНОЛОГИЧЕСКОЙ ЦЕПОЧКЕ ЭЛЕКТРОЛИЗЕ ХЛОРИДА ЩЕЛОЧНЫХ МЕТАЛЛОВ

... 1. Способ получения диарилкарбоната и переработка, по меньшей мере, одной части образованного при этом раствора, содержащего хлорид щелочных металлов, в находящемся ниже по технологической цепочке электролизе хлорида щелочных металлов, включающем следующие стадии: a) получение фосгена взаимодействием хлора с монооксидом углерода, b) взаимодействие фосгена, образованного согласно стадии а), с, по меньшей мере, одним монофенолом в присутствии основания, при необходимости, основного катализатора до диарилкарбоната и раствора, содержащего хлорид щелочных металлов, c) отделение и переработка диарилкарбоната, образованного на стадии b), d) отделение раствора, содержащего хлорид щелочных металлов, оставшегося согласно стадии с), от остатков растворителя и, при необходимости, остатков катализатора, в частности, путем отпаривания раствора с водяным паром и обработкой адсорбентами, в частности, активированным углем, е) электрохимическое окисление, по меньшей мере, одной части раствора, содержащего ...

СПОСОБ ПОЛУЧЕНИЯ ДИАЛКИЛКАРБОНАТОВ

... 1. Способ получения диалкилдикарбонатов путем реакции обмена соответствующих сложных алкиловых эфиров галоидированной муравьиной кислоты, по меньшей мере, с одной гидроокисью или карбонатом щелочного или щелочноземельного металла в присутствии, по меньшей мере, одного не смешиваемого с водой органического растворителя и в присутствии катализатора и отделения конечного продукта, отличающийся тем, что в качестве катализатора используют, по меньшей мере, один третичный алкиламин формулы (I)где R, R, Rобозначают независимо друг от друга С-С-алкил с прямой или разветвленной цепью или С-С-циклоалкил.2. Способ по п.1, отличающийся тем, что в качестве катализаторов используют, по меньшей мере, один третичный алкиламин формулы (I) по п.1, где R, Rи Rнезависимо друг от друга обозначают С-С-алкил с прямой или разветвленной цепью или С-циклоалкил.3. Способ по одному из пп.1 и 2, отличающийся тем, что в качестве катализатора используют, по меньшей мере, один амин из ряда трис-октиламин, трис-изооктиламин ...

Способ получения ариловых эфиров хлоругольной кислоты или циклических карбонатов

VERFAHREN ZUR HERSTELLUNG VON PYROGALLOLVERBINDUNGEN

VERFAHREN ZUR HERSTELLUNG VON CHLORALKYL-CHLORKOHLENSAEUREESTERN

VERBESSERTES VERFAHREN ZUR HERSTELLUNG VON POLYOL-BIS-(ALLYLCARBONATEN)

ETHER PRODRUGS OF ANTI-INFLAMMATORY OXICAMS

VERFAHREN ZUR HERSTELLUNG VON DIARYLCARBONATEN

2-chloro-3-butyne production - from 1-butyn-3-ol

... 2-Chloro-3-butyne, which is of use as an intermediate for synthetic resins, plastics and plant-protection agents (e.g. herbicides), is produced in improved yields and purity by reacting 1-butyn-3-ol with COCl2 in the presence of N,N-dialkyl carboxylic acid amide catalysts (pref. dimethylformamide), the reaction being carried out in two stages in the first of which 1-butyn-3-ol and COCl2 are reacted at 25 degrees C to form 1-butyn-3-yl chloroformate and in the second of which the reaction mixt. is heated at >60 degrees C to form the desired 2-chloro-3-butyne.

A-BROMODIETHYL CARBONATE AND ITS USE IN THE PREPARATION OF ANTIBIOTICS

IMPROVEMENTS IN THE PREPARATION OF ANTIBIOTICS

PRODUCTION OF CHLOROFORMATES

... 1,200,768. Chloroformates and carbonic esters. FISONS PEST CONTROL Ltd. 5 Feb., 1969 [8 Nov., 1967], No. 50808/67. Heading C2C. Chloroformates of the formula R-O-CO-Cl are obtained by reacting (a) hydroxylic compounds of the formula R-OH with (b) phosgene and (c) alkali in a molar ratio of b: c: a of 1À1 to 1À8: 1À1 to 3:1, R being an optionally substituted alkyl, aryl or cycloalkyl group. Carbonic acid esters, R-O-CO-O-R, may be produced as by-products.

CEPHALOSPORINS

... 1487369 Silylated cephalosporins E R SQUIBB & SONS Inc 9 Dec 1974 [28 Dec 1973 10 May 1974] 53116/74 Heading C3S [Also in Division C2] Novel compounds I (R 1 is H, 1-8C alkyl, phenyl or phenyl-1-8C alkyl-optionally substituted by halo, 1-8C alkyl or alkoxy, OH or COOH- or R 1 is 5-6- membered heterocyclyl optionally substituted by halo, 1-8C alkyl or alkoxy or phenyl; R 2 is 1-8C alkyl; R 3 is tri(1-8C alkyl)silyl and R 4 is H, acetoxy, a quaternary ammonium radical, 1-8C alkylthio, heterocyclylthio or a nitrogenlinked radical of an amine) are prepared by reaction of a compound II or an acylating derivative thereof with a compound III ...

PROCESS FOR THE PREPARATION OF CHLOROFORMATES HAVING TERMINAL ACRYLIC OR METHACRYLIC GROUPS

Improvements in and relating to diaryl carbonates

Diaryl carbonates are prepared by heating under anhydrous conditions either phosgene or a phenol monochloroformate with a monophenol and, as catalyst, a phenate (which may be formed in situ) of Be, Mg, Ca, Sr, Ba or Mn. A number of suitable monophenols are listed. Examples describe the preparation of diphenyl, di-a -naphthyl and di-o-cresyl carbonates.

Photochemical process for producing artemisinin.

Photochemical process for producing artemisinin

Photochemical process for producing artemisinin.

New dichlorés derivatives of the series of the 16@- methyl pregnane, their preparation, their application like drugs and compositions containing them.

Photochemical process for producing artemisinin.

VERFAHREN ZUR HERSTELLUNG NEUER DICHLORIERTER DERIVATE AUS DER REIHE DER 16ALPHA -METHYLPREGNANE

VERFAHREN ZUR HERSTELLUNG VON NEUEN CEPHALO- SPORINDERIVATEN

PROCEDURE FOR THE PRODUCTION OF DIARYLCARBONAT

PROCEDURE FOR THE PRODUCTION OF POLYCARBONATES

PRODUCTION OF ESTERS of the 2-CHLORPROPIONSAEURE.

PRODUCTION OPTICAL OF ACTIVE OF CYCLOHEXYLPHENYLGLYKOLSÄUREESTER

Inzektizides and akarizides means

PROCEDURE AND DEVICE FOR THE PRODUCTION OF MONOFONKTIONELLEN HALO FORMIC ACID ARYL STAR

Modulators of ATP-Binding Cassette Transporters

The present invention relates to modulators of ATP-Binding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.

Process for Making Modulators of Cystic Fibrosis Transmembrane Conductance Regulator

The invention provides a process for the preparation of a compound of Formula 1, N H (Rx-X H R2 Formula 1 comprising coupling a carboxylic acid of Formula 2 (Rx-X OH Formula 2 with an aniline of Formula 3 Formula 3 in the presence of a coupling agent.

Method for the production of aliphatic fluoroformates

PREPARATION OF CHLORINE-SUBSTITUTED CHLOROFORMATES

PREPARATION OF CHLORINE-SUBSTITUTED CHLOROFORMATES

This invention as disclosed provides a continuous process for producing chlorine-substituted chloroformates from phosgene and 1-2 epoxy ring compounds. The process comprises: (1) establishing a circulating stream of the chloroformate; (2) passing this stream through a catalyst bed of activated carbon; (3) injecting the phosgene and epoxy compound into the stream ahead of the catalyst, and (4) drawing off the chloroformate as product. The process gives a high yield of chlorine-substituted chloroformates, of a high degree of purity, and does not require added solvents. The product so obtained is useful in preparing flotation reagents and in other organic syntheses.

2-AMINO-SUBSTITUTED ISOTHIOUREIDOBENZENE

... 2-Amino-substituted-isothioureidobenzene products useful as anthelmintics and fungicides are disclosed. The products are prepared by treating 2-amino-thioureidobenzene with a base and an organic halide or sulfonate.

METHYL CHLOROFORMATE PROCESS

B/1089 METHYL CHLOROFORMATE PROCESS of The Disclosure A continuous process for producing high-purity methyl chloroformate, by reacting liquid methanol with an excess of phosgene at no more than 20.degree.C., preferably about 15.degree.C. Phosgene is absorbed in a large circulating load of pre-formed chloroformate that has also had methanol added to it. The product stream is treated to remove light ends, and a 98% pure product results.

CEPHALOSPORIN DERIVATIVES, THEIR PRODUCTION AND USE

CEPHALOSPORIN DERIVATIVES, THEIR PRODUCTION AND USE A compound of the formula: < IMG > wherein R is 2-methylpropyl, 2,2-dimethylpropyl, 1-ethylpropyl, 1-methylbutyl, 2-methylbutyl, 3-methyl-butyl, n-pentyl, an alkyl group of 6 or 7 carbon atoms, or an alkenyl group of 2 to 7 carbon atoms, or a pharmaceutically acceptable salt thereof,and processes for preparing the same,are provided. The compound can orally be applied as antibiotics having improved absorbability.

PREPARATION OF AROMATIC HALOFORMATE

Aromatic chloroformate is prepared by reacting aromatic alcohol and carbonic dihalide in the presence of quaternary phosphonium salt catalyst.

2-AMINO-SUBSTITUTED ISOTHIOUREIDOBENZENE

MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS

... ²² The present invention relates to a compound having formula A-I:²(see formula A-I);²wherein G1, G2 and G3 are as described herein, and processes for making such²compounds.² ...

PROCESS AND CATALYST FOR PRODUCTION OF DIARYL CARBONATES

... 2067375 9106526 PCTABS00005 A process and a heterogeneous catalyst for the production of diaryl carbonates from the reaction of an aromatic hydroxy compound and a carbonyl halide and elimination of anhydrous hydrogen halide. The catalyst comprises a salt containing one or more metal cations and a neutralizing number of anions, said salt being impregnated on an inert porous support which renders the salt insoluble. The process can be carried out under reaction conditions such that the reactants remain in the gas phase when not adsorbed on the catalyst, and, in another embodiment, the products too remain in the gas phase. The process can be carried out in a fixed bed reactor, a fluidized bed reactor, or a circulating fluidized bed reactor.

Verfahren zur Herstellung eines Guajacolderivates.

Verfahren zur Herstellung von ss-Halogenalkylchlorkohlensäureestern.

Verfahren zur Herstellung eines organischen Materials.

Verfahren zur Herstellung von zur selektiven Unkrautbekämpfung geeigneten Verbindungen

Verfahren zum Herstellen von Kunststoffen hoher Schmelzviskosität

Verfahren zur Herstellung von Säurederivaten

Verfahren zur Herstellung von Dialkylpyrocarbonaten

VERFAHREN ZUR HERSTELLUNG VON TERT.-ALKOXYCARBONYLCHLORIDEN.

Verfahren zur Herstellung von Pyrokohlensäureestern

Verfahren zur Herstellung von zur selektiven Unkrautbekämpfung geeigneten Verbindungen

Composition insecticide contenant un dihydronaphthyl-N-méthylcarbamate

Verfahren zur Herstellung von Carbonatgruppen enthaltenden Dihydroxyverbindungen

Verfahren zur Herstellung von Kohlensäureestern

Verfahren zur Herstellung von Indanyl-N-methylcarbaminsäureestern

Procédé de préparation de dérivés du trinitrophénol, dérivé du trinitrophénol préparé selon le procédé et l'utilisation du chloroformiate de picryle résultant du procédé

Verfahren zur Herstellung von Fluorameisensäureestern

Verfahren zur Herstellung von Fluorameisensäure-arylestern

Procédé de préparation d'acides aminés ou de leurs esters, dont le groupe amino ou imino est protégé par le groupe t-amyloxycarbonyle

Procédé de préparation d'esters d'acides aminés protégés par le groupe t-amyloxycarbonyle

Verfahren zur Herstellung von Fluorkohlensäure-tert.-butylester

Chloroformate esters prodn - by continuous reaction of alcohols with phosgene in aerosol phase

... (A) Process for producing aliphatic, substituted aliphatic, cycloaliphatic, aromatic or araliphatic esters of chloroformic acid from the corresponding alcohols and COCl2, in which the reaction is carried out continuously in unidirectional flow in the aerosol phase under isothermal conditions and the chloroformic acid ester obtained is separated from HCl and excess COCl2. (B) Apparatus for carrying out the above process, consisting of a glass reactor column (1) which is divided into a reaction zone (2), a packed zone (3) and a condensation zone (4) and which is connected to means (5) for separating off the reaction mixture. Chloroformic acid esters are used in the pharmaceutical industry and other branches of the chemical industry (e.g. for producing compounds of the carbamate type). The esters are obtained in very good yields and very high purity. Residence times in the reactor are very short, so that small and therefore inexpensive apparatus can be used. In addition, only small amounts ...

Process for the preparation of isothioureidobenzenes

[...] DE SYNTHESIS DE [...][...] A [...] OU [...].

[...] DE SYNTHESIS INDUSTRIAL DE [...] ET D' [...][...] ET [...] DE.

Acaricide and aphicide

PROCEDURE FOR THE PROTECTION OF REACTIVE GROUPS.

CLOROFORMIATI OF FOREIGN COUNTRIES C-ALCHIL OR C-ALOGENOALCHIL-TARTRONICI.

Cephalosporin derivatives, process for their preparation and pharmaceutical preparations containing them

SYNTHESIS OF BIS (ALLYL CARBONATE) POLYOL COMPRISING THE RECOVERY AND RECYCLING OF THE REAGENT.

PROCEDURE FOR THE PRODUCTION OF A AMPICILLIN ESTER.

ALPHA BROMINE DIA. ETHYL CARBONATE, PROCEDURE FOR ITS PRODUCTION AND ITS USE FOR THE PRODUCTION OF PENICILLIN AND CEFALOSPORINESTERN.

THE DERIVATIVES [...] 16ALPHA-METHYL-PREGNANE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC COMPOSITIONS CONTAINING THEM.

COMPOSED FUNGICIDE.

ФОТОХИМИЧЕСКИЙ СПОСОБ ПОЛУЧЕНИЯ АРТЕМИСИНИНА

Описан новый фотохимический способ получения артемисинина. Также описаны некоторые производные дигидроартемисиновой кислоты, подходящие для получения артемисинина.

Production of diaryl carbonate

PROCESS FOR THE PREPARATION OF CHLOROFORMIC ACID ARYL ESTERS AND CYCLIC CARBONATES

ESTERS OF CEFUROXIME, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION

NEW DERIVATIVES DICHLORES OF the SERIES OF 16A-METHYL PREGNANE, THEIR METHOD OF PREPARATION AND THEIR APPLICATION LIKE DRUGS

PROCESS FOR THE PREPARATION OF THE METHYL CHLOROFORMIATE

PROCESS IMPROVES MANUFACTURE OF THE CHLOROFORMIATE OF TRICHLOROETHYLE

METHOD OF PREPARATION OF (A) (ALLYLCARBONATES) OF POLYOL WITH RECOVERY AND RECYCLING OF REAGENTS

PROCEDE DE SYNTHESE D'ESTERS ACTIFS D'ACIDES CARBOXYLIQUES, NOUVEAUX CARBONATES ALPHA-HALOGENES UTILES POUR CETTE SYNTHESE ET LEUR MODE D'OBTENTION

L'INVENTION CONCERNE UN NOUVEAU PROCEDE DE PREPARATION D'ESTERS ACTIFS D'ACIDES CARBOXYLIQUES QUI CONSISTE A FAIRE REAGIR SUR UN ACIDE CARBOXYLIQUE EN PRESENCE D'UN AGENT DE FIXATION D'ACIDE HALOHYDRIQUE UN CARBONATE DE FORMULE:R-O-C-O-CH-RDANS LAQUELLE R REPRESENTE SOIT UN RADICAL DE FORMULE ...

PROCEDE DE PREPARATION DE CHLOROFORMIATES A-CHLORES

PROCEDE DE PREPARATION DE CHLOROFORMIATES A-CHLORES DE FORMULE: (CF DESSIN DANS BOPI) DANS LAQUELLE R EST H, UN RADICAL HYDROCARBONE ALIPHATIQUE AROMATIQUE OU HETEROCYCLIQUE, SUBSTITUE OU NON ET N UN NOMBRE ENTIER. LE PROCEDE CONSISTE A FAIRE REAGIR SUR UN ALDEHYDE DE FORMULE R-(CHO)N, C1COOCC1, C1COCOOCC1 EN PRESENCE D'UN COMPOSE LIBERANT DANS LE MILIEU UNE PAIRE D'IONS, DONT L'ANION EST UNE HALOGENURE QUI POURRA ATTAQUER LA FONCTION ALDEHYDE, ETANT DONNE LE FAIBLE POUVOIR ATTRACTEUR DU CATION DE CE COMPOSE.

Manufactoring process of aryl chloroformiates

Process for the manufacture of the methyl chloroformiate

PROCESS FOR THE PREPARATION OF SUBSTITUTED DINITROPHENYL CHLOROFORMATES

METHOD OF PREPARATION OF EASILY DECOMPOSABLE CHLOROFORMIATES

Azidoformates and their homopolymers and copolymers and compositions of coating the container

Process for the preparation of trichloromethylphenyl chloroformate

NEW DERIVATIVES DICHLORES OF the SERIES OF 16A-METHYL PREGNANE, THEIR METHOD OF PREPARATION AND THEIR APPLICATION LIKE DRUGS

BENZIMIDAZOLES 1-SUBSTITUES ANTIFONGIQUES

PROCESS FOR MAKING MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR

Process for Making Modulators of Cystic Fibrosis Transmembrane Conductance Regulator

The invention provides a process for the preparation of a compound of Formula 1, comprising coupling a carboxylic acid of Formula 2 with an aniline of Formula 3 in the presence of a coupling agent.

Device and process for continuous phosgenation

A continuous process for generation of phosgene from CO and Cl 2 and consumption of the phosgene thus generated in a liquid-phase reaction so as to form organic products P. The process is implemented in two successive reactors R1 and R2, the first reactor R1 being a reactor for catalytic synthesis of phosgene from CO and Cl2 gas, and the second reactor R2 being a piston reactor, the second reactor R2 being equipped with a mechanical axial agitation device.

Modulators of atp-binding cassette transporters

The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.

METHOD FOR PRODUCING DIARYL CARBONATE

The present application relates to a method for the continuous production of diaryl carbonate from phosgene and of at least one monohydroxy compound (monophenol) in the presence of catalysts, and to the use thereof for the production of polycarbonates. 111.-. (canceled)12. A process for preparing diaryl carbonate by reaction of an aromatic hydroxyl compound and a halogenated carbonyl in the presence of a catalyst in a reactor , wherein the ratio G/A is less than 0.010 , where G is the entry volume flow rate of the liquid or dissolved halogenated carbonyl in m/s and A is the internal cross-sectional area orthogonal to the longitudinal axis in m.13. The process as claimed in claim 12 , wherein the reaction takes place in a bubble column reactor in the absence of a solvent.14. The process as claimed in claim 12 , wherein G/A is in the range from 0.0005 [m/s] and 0.0095 [m/s].15. The process as claimed in claim 12 , wherein the ratio H/D is greater than or equal to 2 and H is the height of the liquid phase in the reactor in the gas-free state and D is the diameter of the reactor.16. The process as claimed in claim 12 , wherein the residence time in the reactor is in the range from 0.5 to 4 hours claim 12 , the temperature is in the range from 120 to 220° C. and the pressure is 3 to 100 bar.17. The process as claimed in claim 12 , wherein the halogenated carbonyl is phosgene.18. The process as claimed in claim 12 , wherein the aromatic hydroxyl compound is phenol.19. The process as claimed in claim 12 , wherein the catalyst is pyridine claim 12 , pyridine*HCl claim 12 , TiCl claim 12 , Ti(OPh)or AlCl.20. The process as claimed in claim 12 , wherein the reactor is at least one bubble column reactor.21. The process as claimed in claim 12 , wherein the process is conducted in at least two stages.22. The process as claimed in claim 12 , wherein the phosgene content at the reactor outlet in the liquid phase is less than 100 ppm. The present application relates to a process ...

Method for producing carbonates

In an embodiment, a method of producing a carbonate comprises reacting carbon monoxide and chlorine in a phosgene reactor in the presence of a catalyst to produce a first product comprising phosgene; wherein carbon tetrachloride is present in the first product in an amount of 0 to 10 ppm by volume based on the total volume of phosgene; and reacting a monohydroxy compound with the phosgene to produce the carbonate; wherein the phosgene reactor comprises a tube, a shell, and a space located between the tube and the shell; wherein the tube comprises one or more of a mini-tube section and a second tube section; a first concentric tube concentrically located in the shell; a twisted tube; an internal scaffold; and an external scaffold.

METHOD FOR PREPARING DIALKYL DICARBONATES USING AMINE OXIDES

The present invention relates to a method for preparing dialkyl dicarbonates from the corresponding alkyl chloroformates using specific amine oxides as catalysts. 2. The method according to claim 1 , wherein Ris selected from the group of straight-chain or branched dodecanyl claim 1 , undecanyl claim 1 , tridecanyl claim 1 , tetradecanyl claim 1 , pentadecanyl claim 1 , hexadecanyl claim 1 , heptadecanyl claim 1 , octadecanyl claim 1 , nonadecanyl claim 1 , eicosanyl claim 1 , icosanyl claim 1 , heneicosanyl and dodoconyl.3. The method according to claim 1 , wherein Ris selected from the group of straight-chain or branched C- claim 1 , C claim 1 , C- claim 1 , C- claim 1 , C- claim 1 , C- claim 1 , C- claim 1 , C- claim 1 , and C-alkyl.4. The method according to claim 1 , wherein Rand Rare selected from the group of methyl claim 1 , ethyl claim 1 , n-propyl claim 1 , s-propyl claim 1 , n-butyl claim 1 , s-butyl claim 1 , isobutyl and t-butyl and Ris straight-chain or branched C-C-alkyl.5. The method according to claim 1 , wherein Rand Rare methyl and Ris C-C-alkyl.6. The method according to claim 1 , wherein Rand Rare methyl and Ris selected from the group of dodecanyl claim 1 , tetradecanyl claim 1 , and hexadecanyl.7. The method according to claim 1 , wherein Ris selected from the group of straight-chain or branched C- claim 1 , C- and C-alkyl and Rand Rare methyl and wherein the content of the compound where R=C-alkyl is from 60% by weight to 80% by weight and the content of the compound where R=C-alkyl is from 19% by weight to 30% by weight and the content of the compound where R=C-alkyl is from 1% by weight to 10% by weight claim 1 , based on the total weight of the compound of the formula (I).9. The method according to claim 8 , wherein Ris methyl claim 8 , ethyl claim 8 , n-propyl claim 8 , isopropyl claim 8 , or n-butyl or isobutyl.10. The method according to claim 1 , wherein the alkali metal hydroxides or alkaline earth metal hydroxides and/or carbonates ...

Modulators of atp-binding cassette transporters

The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.

Synthetic route to anti-viral agents

The invention provides methods of synthesizing a viral protease inhibitor in high yield, without using expensive catalysts or challenging reaction conditions.

Modulators of atp-binding cassette transporters

The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.

Process for preparation of 2-amino-5-hydroxy propiophenone

The present invention relates to a process for preparation of 2-Amino-5-hydroxy propiophenone, a key intermediate for the synthesis of camptothecin analogs including 7-Ethyl-10-hydroxycamptothecin (SN-38).

METHOD FOR PRODUCING DIARYL CARBONATES

The invention concerns a method for producing diaryl carbonates from monophenols and phosgene or chloroformic acid aryl esters in the presence of an optionally substituted pyridine or the hydrochloride salt thereof as catalyst, and the recovery and reinjection thereof back into the method. The method is carried out at least partially in a liquid phase without the use of an additional solvent, the catalyst being separated by means of crystallization and recovered. 1. A process for preparing diaryl carbonate comprising:a) reacting a monophenol with phosgene and/or at least one aryl chloroformate in the presence of at least one optionally substituted pyridine, in free form and/or in the form of a hydrochloride salt thereof, as catalyst, wherein the reaction is carried out in a reactor under pressures of 1-50 bar,b) transferring the reaction mixture from the reactor into an apparatus configured for suspension crystallization,c) lowering the temperature in the apparatus, thereby introducing the suspension crystallization and forming a crystallizate,d) separating the crystallizate from the remaining catalyst-containing mother liquor, ande) at least partially recirculating the catalyst-containing mother liquor into the reactor at step a).2. The process as claimed in claim 1 , wherein the monophenol comprises phenol.3. The process as claimed in claim 1 , wherein not more than 10 mol % of the optionally substituted pyridine is present in free form.4. The process as claimed in claim 3 , wherein the catalyst comprises pyridine hydrochloride.5. The process as claimed in claim 1 , wherein an aqueous solution is not used in any of the steps a) to e).6. The process as claimed in wherein hydrogen chloride formed in step a) is not neutralized.7. The process as claimed in claim 1 , wherein hydrogen chloride formed in step a) is separated off by distillation.8. The process as claimed in claim 1 , wherein the ratio of monophenol to diaryl carbonate is set before step c) by a thermal ...

METHOD FOR PRODUCING DIARYL CARBONATES

The invention concerns a method for producing diaryl carbonates from monophenols and phosgene or chloroformic acid aryl esters in the presence of at least one optionally substituted pyridine or the hydrochloride salt thereof as catalyst, and the recovery and reinjection thereof back into the method. The method is carried out at least partially in a liquid phase without the use of an additional solvent, the catalyst being separated by means of distillation and recovered. 1. A process for preparing diaryl carbonate comprising:a. reacting at least one monophenol with phosgene and/or at least one aryl chloroformate in the presence of at least one optionally substituted pyridine, in free form and/or in the form of a hydrochloride salt thereof, as catalyst, wherein the reaction is carried out in a reactor under pressures of 1-50 bar (absolute),b. transferring the reaction mixture from the reactor into a single-stage distillation apparatus or a multistage distillation apparatus,c. separating a catalyst-containing distillate off at the top of at least one distillation column,d. at least partially recirculating the catalyst-containing distillate into the reactor at step a), ande. separating diaryl carbonate off via a side stream from the distillation apparatus.2. The process as claimed in claim 1 , wherein the at least one monophenol comprises phenol.3. The process as claimed in claim 1 , wherein not more than 10 mol % of the optionally substituted pyridine is present in free form.4. The process as claimed in claim 3 , wherein the catalyst comprises pyridine hydrochloride.5. The process as claimed in claim 1 , wherein an aqueous solution is not used in any of the steps a) to e).6. The process as claimed in claim 1 , wherein the hydrogen chloride formed in step a) is not neutralized.7. The process as claimed in claim 1 , wherein hydrogen chloride formed in step a) is separated off by distillation in a first distillation stage and the catalyst-containing distillate and the ...

Modulators of atp-binding cassette transporters

The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.

PROCESS FOR PREPARING 3-CHLORO-2-VINYLPHENYLSULFONATES

The present invention relates to a new process for preparing 3-chloro-2-vinylphenylsulfonate derivatives. 2. A process according to claim 1 , wherein{'sup': '1', 'Rrepresents methyl, ethyl, n-propyl, i-propyl, n-butyl, phenyl, 4-methylphenyl or benzyl;'}{'sup': '2', 'sub': 3', '2', '3', '2', '2', '3, 'Rrepresents F, Cl, FC, FHC, ClC, ClHC, ClHC or ClCO;'}{'sup': 3', '4, 'sub': 3', '2', '3', '2', '2, 'Rand Rindependently from each other represent FC, FHC, ClC, ClHC or ClHC;'}{'sup': '5', 'sub': 3', '2', '2', '3', '2, 'Rrepresents F, Cl, CCl, CHCl, CHCl, CF, CHFor 3-chloro-2-methylphenoxy;'}{'sup': '6', 'sub': 3', '2', '2', '3', '2, 'Rrepresents F, Cl, CCl, CHCl, CHCl, CF, CHFor 3-chloro-2-(dichloromethyl) phenoxy;'}{'sub': '2', 'sup': '1', 'W represents F, Cl or OSOR;'}Q represents Na, K, MgCl or MgBr.3. A process according to claim 1 , wherein{'sup': '1', 'Rrepresents methyl, ethyl, n-propyl, phenyl, 4-methylphenyl;'}{'sup': '2', 'sub': 3', '2', '3', '2', '2', '3, 'Rrepresents F, Cl, FC, FHC, ClC, ClHC, ClHC or ClCO;'}{'sup': 3', '4, 'sub': 3', '3', '2', '2, 'Rand Rindependently from each other represent FC, ClC, ClHC, ClHC;'}{'sup': '5', 'sub': 3', '2', '2', '3', '2, 'Rrepresents F, Cl, CCl, CHCl, CHCl, CF, FHC or 3-chloro-2-methylphenoxy;'}{'sup': '6', 'sub': 3', '2', '2', '3', '2, 'Rrepresents F, Cl, CCl, CHCl, CHCl, CF, FHC or 3-chloro-2-(dichloro)methylphenoxy;'}{'sub': '2', 'sup': '1', 'W represents F, Cl or OSOR;'}Q represents Na, K, MgCl or MgBr.4. A process according to claim 1 , wherein{'sup': '1', 'Rrepresents methyl or 4-methylphenyl;'}{'sup': '2', 'sub': 3', '3, 'Rrepresents F, Cl, FC or ClCO;'}{'sup': 3', '4, 'sub': 3', '3, 'Rand Rindependently from each other represent FC or ClC;'}{'sup': '5', 'sub': 3', '3, 'Rrepresents F, Cl, CCl, FC or 3-chloro-2-methylphenoxy;'}{'sup': '6', 'sub': 3', '3, 'Rrepresents F, Cl, CCl, FC or 3-chloro-2-(dichloro)methylphenoxy;'}{'sub': '2', 'sup': '1', 'W represents F, Cl or OSOR;'}Q represents MgCl or MgBr.5. A process ...

SYNTHETIC ROUTE TO ANTI-VIRAL AGENTS

The invention provides methods of synthesizing a viral protease inhibitor in high yield, without using expensive catalysts or challenging reaction conditions. 118-. (canceled)23. The composition of claim 22 , wherein solvent A is dichloromethane.24. The composition of or claim 22 , wherein solvent B comprises water.29. The composition of claim 28 , wherein solvent A is dichloromethane.30. The composition of or claim 28 , wherein solvent B comprises water.35. The composition of claim 34 , wherein solvent A is dichloromethane.36. The composition of or claim 34 , wherein solvent B comprises water. This application claims the benefit of priority to U.S. Provisional Patent Application Ser. No. 62/026,412, filed Jul. 18, 2014, the contents of which are hereby incorporated by reference.Complex biologically active molecules are challenging, expensive, and time-consuming to synthesize. Synthesizing chiral, non-racemic compounds with good enantio- and diastereoselectivity is even more challenging. An example of such a molecule is Compound 1:This compound is a potent inhibitor of the hepatitis C virus (HCV) NS3/4A protease; it shows broad genotype activity and substantially improved in vitro profile compared to earlier generation HCV NS3/4A protease inhibitors.The original synthesis of this compound requires a ring closing metathesis (RCM) reaction for synthesis of the macrocycle (see WO 2012/040167). However, this RCM reaction involves high catalyst loading and expensive starting materials, resulting in low throughput due to dilute reaction conditions and increased costs.There exists a need for new, efficient synthetic methods to construct Compound 1.In certain embodiments, the invention relates to a compound selected from:or a salt thereof.In certain embodiments, the invention relates to a compound selected from:or a salt thereof.In certain embodiments, the invention relates to a compound selected from:or a salt thereof.In certain embodiments, the invention relates to a ...

SYNTHETIC ROUTE TO ANTI-VIRAL AGENTS

The invention provides methods of synthesizing a viral protease inhibitor in high yield, without using expensive catalysts or challenging reaction conditions. 118-. (canceled)20. The method of claim 19 , wherein the solvent comprises toluene claim 19 , dichloromethane claim 19 , THF claim 19 , acetone claim 19 , heptane claim 19 , hexane claim 19 , methyl tert-butyl ether claim 19 , ethyl acetate claim 19 , dioxane claim 19 , DMF claim 19 , DMA claim 19 , acetonitrile claim 19 , or DMSO claim 19 , or a mixture thereof.21. The method of claim 20 , wherein the solvent comprises toluene claim 20 , acetonitrile claim 20 , or dichloromethane or a mixture thereof.22. The method of claim 19 , wherein the reaction of scheme B takes place at a temperature from about −20° C. to about 10° C.23. The method of claim 22 , wherein the temperature is about −20° C. claim 22 , about −15° C. claim 22 , about −10° C. claim 22 , about −5° C. claim 22 , about 0° C. claim 22 , about 5° C. claim 22 , or about 10° C.24. The method of claim 22 , wherein the temperature is about −10° C. to about 10° C.25. The method of claim 22 , wherein the temperature is about 0° C. This application claims the benefit of priority to U.S. Provisional Patent Application Ser. No. 62/026,412, filed Jul. 18, 2014, the contents of which are hereby incorporated by reference.Complex biologically active molecules are challenging, expensive, and time-consuming to synthesize. Synthesizing chiral, non-racemic compounds with good enantio- and diastereoselectivity is even more challenging. An example of such a molecule is Compound 1:This compound is a potent inhibitor of the hepatitis C virus (HCV) NS3/4A protease; it shows broad genotype activity and substantially improved in vitro profile compared to earlier generation HCV NS3/4A protease inhibitors.The original synthesis of this compound requires a ring closing metathesis (RCM) reaction for synthesis of the macrocycle (see WO 2012/040167). However, this RCM reaction ...

Process for the work-up and reuse of salt-containing process water

A process for the work-up of salt-containing process water which contains an alkali metal chloride as salt in a concentration of at least 4% by weight and organic or inorganic and organic impurities from chemical production processes and reuse of the salt by a combination of prepurification and concentration, crystallization and purification of the salt and optionally subsequently use of the salt in an electrolysis for producing basic chemicals are described.

PURIFICATION OF AROMA CHEMICALS

The presently claimed invention relates to a process for purification of aroma compounds by distillation. Specifically, it relates to a process for purification of carbonic esters of formula (I) using a combination of distillative processes. 118.-. (canceled)22. The method according to claim 19 , wherein in step a) the steam stripping is carried out in a stripping column having a sump temperature in the range of ≥50° C. to ≤120° C. and head temperature in the range of ≥40° C. to ≤60° C.23. The method according to claim 19 , wherein the steam stripping is carried out at a pressure in the range of ≥100 mbar to ≤200 mbar.24. The method according to claim 19 , wherein in step a) the mixture comprises at least one compound having a vapor pressure in the range of ≥0.0001 bar to ≤0.20 bar at 60° C.25. The method according to claim 24 , wherein the at least one compound having a vapor pressure in the range of ≥0.0001 bar to ≤0.20 bar at 60° C. is selected from the group consisting of non-polar organic solvents and impurities formed during the synthesis of the carbonic esters of formula (I).26. The method according to claim 25 , wherein the non-polar organic solvents are selected from the group consisting of aliphatic hydrocarbons claim 25 , aromatic hydrocarbons and ethers.27. The method according to claim 25 , wherein the impurities formed during the synthesis of carbonic esters of formula (I) are menthyl chloride and menthol.28. The method according to claim 25 , wherein the mixture comprising at least one compound having a vapor pressure in the range of ≥0.0001 bar to ≤0.20 bar at 60° C. is further separated by batch distillation.29. The method according to claim 28 , wherein the batch distillation is carried out at a sump temperature range of ≥50° C. to ≤80° C. and head temperature in the range of ≥30° C. to ≤60° C.30. The method according to claim 28 , wherein the batch distillation is carried out at a pressure in the range of ≥50 mbar to ≤150 mbar.31. The method ...

FLUORINATED CARBONATES COMPRISING DOUBLE BOND-CONTAINING GROUPS, METHODS FOR THEIR MANUFACTURE AND USES THEREOF

Fluorinated carbonates comprising double-bond containing groups were prepared and their use as solvent additives or solvents in lithium ion batteries, lithium air batteries, lithium sulphur batteries and supercapacitors is described. Preferred compounds contain at least one alkenyl or at least one (hetero)aryl group. 1. A compound of general formula (I) ,{'br': None, 'sup': 1', '2', '3, 'RRCF—O—C(O)—O—R'}{'sup': 1', '2, 'wherein Rand Rare independently H, F, alkyl, cycloalkyl, alkylene-aryl, or alkylene-heteroaryl; and'}{'sup': '3', 'wherein Ris a double bond-containing group.'}2. The compound according to wherein Ris an alkenyl.3. The compound according to wherein Ris an aryl group or an alkylene-aryl group.4. The compound according to wherein Ris H.5. The compound according to wherein Ris H or an alkyl group.6. The compound according to wherein R1 is methyl claim 1 , R2 is H claim 1 , R3 is allyl and the compound is (1-fluoroethyl)allyl carbonate.7. The compound according to wherein R1 is methyl claim 1 , R2 is H claim 1 , R3 is phenyl and the compound is (1-fluoroethyl)phenyl carbonate.8. A method for the manufacture of a compound of general formula (I) claim 1 ,{'br': None, 'sup': 1', '2', '3, 'RRCF—O—C(O)—O—R'} {'br': None, 'sup': 1', '2, 'RRCF—O—C(O)F'}, 'the method comprising a step of reacting a fluoroformate of general formula (II),'}{'sup': '3', 'with an alcohol of general formula (III), R—OH;'}{'sup': '1', 'wherein Ris H, F, alkyl, cycloalkyl, alkylene-aryl, or alkylene-heteroaryl;'}{'sup': '2', 'wherein Ris H, and'}{'sup': '3', 'wherein Ris a double bond-containing group.'}9. A method for the manufacture of a compound of general formula (I) claim 1 ,{'br': None, 'sup': 1', '2', '3, 'RRCF—O—C(O)—O—R'}{'sup': 1', '2, 'claim-text': {'br': None, 'sup': 1', '2, 'RRCF—O—C(O)X'}, 'the method comprising a first step of reacting phosgene or a phosgene analogue with a compound of the general formula (IV) RRCF—OH to form an intermediate of the general formula (V ...

PROCESS FOR PRODUCING CHLOROFORMATE COMPOUND

The present invention provides a method for safely producing a large amount of chloroformate compound with high yield. The chloroformate compound can be produced by mixing and reacting a solution of triphosgene, an amine and an alcohol compound in a flow reactor. The chloroformate compound can also be produced by mixing and reacting a solution of triphosgene with a solution comprising an amine and an alcohol compound in a flow reactor. The amine is preferably tributylamine, and preferably used in an amount of 0.8 to 3 equivalents relative to an amount of the alcohol compound. 1: A process for producing a chloroformate compound , comprising:mixing and reacting a first solution comprising triphosgene with a second solution comprising an amine compound and an alcohol compound in a flow reactor.2: The process according to claim 1 , wherein the amine compound is tributylamine.3: The process according to claim 1 , wherein an amount of the amine compound is 0.8 to 3 equivalents relative to an amount of the alcohol compound.4: The process according to claim 1 , wherein each of the first solution and the second solution comprises a solvent selected from the group consisting of an aromatic hydrocarbon solvent claim 1 , an ether solvent claim 1 , and a combination thereof.5: The process according to claim 1 , wherein each of the first solution and the second solution comprises a solvent selected from the group consisting of toluene claim 1 , tetrahydrofuran claim 1 , and a combination thereof.6: The process according to claim 1 , wherein an amount of the triphosgene is 0.3 to 1 equivalent relative to an amount of the alcohol compound.7: The process according to claim 1 , wherein a flow channel of the flow reactor has a cross-sectional area of 10 mmto 30 cm.8: The process according to claim 1 , wherein a reaction temperature in a flow channel of the flow reactor is 60° C. or lower.9: The process according to claim 1 , wherein a retention time in a flow channel of the flow ...

FLUORINATED CARBONATES COMPRISING DOUBLE BOND-CONTAINING GROUPS, METHODS FOR THEIR MANUFACTURE AND USES THEREOF

Fluorinated carbonates comprising double-bond containing groups were prepared and their use as solvent additives or solvents in lithium ion batteries, lithium air batteries, lithium sulphur batteries and supercapacitors is described. Preferred compounds contain at least one alkenyl or at least one (hetero)aryl group. 1. A compound of general formula (I) ,{'br': None, 'sup': 1', '2', '3, 'RRCF—O—C(O)—O—R'}{'sup': '1', 'wherein Ris methyl, ethyl, propyl, isopropyl, butyl, t-butyl, pentyl, isopentyl or hexyl,'}{'sup': '2', 'Ris H; and'}{'sup': '3', 'Ris an alkenyl group.'}2. (canceled)3. (canceled)4. (canceled)5. (canceled)6. The compound according to wherein R1 is methyl claim 1 , R2 is H claim 1 , R3 is allyl and the compound is (1-fluoroethyl)allyl carbonate.7. (canceled)8. A method for the manufacture of a compound of general formula (I) claim 1 ,{'br': None, 'sup': 1', '2', '3, 'RRCF—O—C(O)—O—R'} {'br': None, 'sup': 1', '2, 'RRCF—O—C(O)F'}, 'the method comprising a step of reacting a fluoroformate of general formula (II),'}{'sup': '3', 'with an alcohol of general formula (III), R—OH;'}{'sup': '1', 'wherein Ris H, F, alkyl, cycloalkyl, alkylene-aryl, or alkylene-heteroaryl;'}{'sup': '2', 'wherein Ris H, and'}{'sup': '3', 'wherein Ris a double bond-containing group.'}9. A method for the manufacture of a compound of general formula (I) claim 1 ,{'br': None, 'sup': 1', '2', '3, 'RRCF—O—C(O)—O—R'}{'sup': 1', '2, 'claim-text': {'br': None, 'sup': 1', '2, 'RRCF—O—C(O)X'}, 'the method comprising a first step of reacting phosgene or a phosgene analogue with a compound of the general formula (IV) RRCF—OH to form an intermediate of the general formula (V)'}{'sup': '3', 'and a second step of reacting the intermediate of the general formula (V) with a compound of the general formula (VI) R—OH;'}{'sup': '3', 'claim-text': {'br': None, 'sup': '3', 'R—O—C(O)X'}, 'or comprising a first step of reacting phosgene or a phosgene analogue with a compound of the general formula (VI) R— ...

Fluorinated carbonyl compounds comprising a triple bond, methods for their manufacture and uses thereof

Fluorinated carbonyl compounds comprising a triple bond were prepared and their use as solvent additives or solvents in lithium ion batteries, lithium air batteries, lithium sulphur batteries and supercapacitors is described. Preferred compounds contain at least one nitrile or at least one alkynyl group.

PROCESS FOR PURIFICATION OF DIPHENYL CARBONATE FOR THE MANUFACTURING OF HIGH QUALITY POLYCARBONATE

A process for purifying a diaryl carbonate, comprises introducing an aqueous stream to a diaryl carbonate stream that comprises a metal contaminant, wherein the aqueous stream reacts with the metal contaminant to form a precipitate; wherein introducing the aqueous stream to the diaryl carbonate stream results in introducing 100 to 10,000 ppm water based on the total composition of the diaryl carbonate stream and the aqueous stream; removing the precipitate via one or both of a separation column and a filter to result in a purified diaryl carbonate. 1. A process for purifying a diaryl carbonate , comprising:introducing an aqueous stream to a diaryl carbonate stream that comprises a metal contaminant, wherein the diaryl carbonate stream comprises greater than or equal to 70 wt % diaryl carbonate based on the total weight of the diaryl carbonate stream, wherein the aqueous stream reacts with the metal contaminant to form a precipitate; wherein introducing the aqueous stream to the diaryl carbonate stream results in introducing 100 to 10,000 ppm water based on the total composition of the diaryl carbonate stream and the aqueous stream;removing the precipitate via one or both of a separation column and a filter to result in a purified diaryl carbonate; removing a bottom stream comprising the precipitate from the separation column;', 'removing a top stream from the separation column;', 'directing a top stream first portion into the separation column and collecting a top stream second portion, wherein the top stream second component comprises the purified diaryl carbonate., 'wherein when the removing utilizes the separation column, the process further comprises2. The process of claim 1 , wherein the removing utilizes the separation column claim 1 , and wherein the introducing occurs before the diaryl carbonate stream enters the separation column.3. The process of claim 1 , wherein the removing utilizes the separation column claim 1 , and wherein the introducing occurs ...

METHOD FOR PRODUCING DIALKYLDICARBONATES USING TERTIARY AMINES AS CATALYSTS

The present invention relates to a method for preparing dialkyl dicarbonates from the corresponding alkyl chloroformates using specific tertiary amines as catalysts. 2. The method as claimed in claim 1 , wherein the at least one tertiary amine of the formula (I) comprises at least one tertiary alkylamine of the formula (I) where:{'sup': '1', 'R=methyl, ethyl, propyl or butyl,'}{'sup': '2', 'sub': 17', '20, 'R=C-C-alkyl, and'}{'sup': '3', 'sub': 2', '3', 'n', '2', '3', '2', '2', '2', 'n', '2', '2', '2, 'R=—[CH—CH(CH)—O]—[CH—CH(CH)]—OH or —[CH—CH—CH—O]—[CH—CH—CH]—OH where n=6 to 10.'}3. The method as claimed in claim 2 , wherein:{'sup': '1', 'R=methyl,'}{'sup': '2', 'sub': '18', 'R=straight-chain C-alkyl, and'}{'sup': '3', 'sub': 2', '2', 'n', '2', '3, 'R=—[CH—CH(CH)—O]—[CH—CH(CH)]—OH where n=8.'}4. The method as claimed in claim 1 , wherein:the catalyst comprises a mixture of two or more different tertiary amines of the formula (I), and{'sup': '3', 'sub': 2', '3', 'n', '2', '3, 'Ris —[CH—(CH(CH))—O]—[CH—(CH(CH))]—OH where n =8, 9, 10 or 11.'}5. The method as claimed in claim 1 , wherein the catalyst comprises a mixture of the tertiary amines of the formula (I) claim 1 , comprising various radicals Rthat are straight-chain or branched C- claim 1 , C- claim 1 , C- claim 1 , C- claim 1 , C- or C-alkyl.7. The method as claimed in claim 1 , wherein the alkali metal hydroxides claim 1 , alkaline earth metal hydroxides and/or carbonates are in the form of aqueous solutions.8. The method as claimed in claim 1 , wherein the at least one water-immiscible organic solvent is selected claim 1 , from the group consisting of aliphatic and aromatic hydrocarbons claim 1 , chlorinated hydrocarbons claim 1 , dialkyl carbonates claim 1 , and water-immiscible ethers and esters.9. The method as claimed in claim 1 , wherein the contacting is done in the presence of 0.001 to 0.5 mol % of the tertiary amines of the formula (I) is claim 1 , based on the alkyl haloformates.10. The method as ...

METHOD FOR PRODUCING FLUORINE-CONTAINING DIALKYL CARBONATE COMPOUNDS

The present invention relates to a method for producing fluorine-containing dialkyl carbonate compounds, which are suitable as non-aqueous solvents for non-aqueous electrolytes used in secondary batteries. When an alkyl chloroformate and an alcohol are reacted in the presence of an ether-containing imidazole derivative base, the reaction can be carried out at room temperature as compared with the prior art, and the products can be separated within a short time from the reactants. This is an economical process, and according to the present invention, it is possible to obtain alkyl carbonates containing fluorine atoms simply and without difficulty in the removal of solvents, salts formed during the reaction, and by-products. Accordingly, the production method of the present invention can be effectively applied to the production of fluorine-containing dialkyl carbonates used for various applications such as electrolytes of lithium ion secondary batteries, medicines and fine chemicals, pesticides, polar aprotic solvents, synthetic lubricating oils and the like. 2. The method for producing a dialkyl carbonate of claim 1 , wherein the reaction temperature is in the range of 10 to 35° C.3. The method for producing a dialkyl carbonate of claim 1 , wherein the separation of the reaction product from the reactants is performed by layer separation.4. The method for producing a dialkyl carbonate of claim 1 , wherein the base is 1-(2-ethoxyethyl) imidazole.5. The method for producing a dialkyl carbonate of claim 1 , wherein the reaction time is less than 6 hours.6. The method for producing a dialkyl carbonate of claim 1 , wherein the mixing molar ratio of the base claim 1 , the alkyl chloroformate and the alcohol is 1:1:1. The present invention relates to a method for producing fluorine (F)-containing dialkyl carbonate compounds. More specifically, the present invention relates to a method for producing fluorine-containing dialkyl carbonate compounds by reacting an alkyl ...

PROCESS FOR THE MANUFACTURE OF 1, 1'-DIFLUOROSUBSTITUTED DIALKYL CARBONATES, ISOMERS THEREOF AND ELECTROLYTE COMPOSITIONS CONTAINING THEM

Fluoroalkyl alkyl carbonates which are suitable as additives or solvents in lithium ion batteries are prepared from fluoroalkyl fluoroformiates and an aldehyde, preferably formaldehyde and acetaldehyde. 1,1′-difluoromethyl carbonate and 1,1′-di-fluorodiethylcarbonate are the preferred compounds prepared by the process of the present invention. 1. A process for the manufacture of 1 ,1′-difluorodialkyl carbonates of the general formula (I) , RCHF—OC(O)—OCHFR , wherein Rand Rare the same or different and denote H or linear or branched alkyl with 1 to 3 C atoms , the process comprising reacting a fluoroformiate of formula (II) , RCHFOC(O)F wherein Rhas the meaning given above , with an aldehyde of formula (III) , R—CH(O) wherein Rhas the meaning given above.2. The process of wherein Ris H or CH.3. The process of wherein Ris H or CH.4. The process of wherein CHF—OC(O)—OCHF or CHCHF—OC(O)—OCHFCHare produced.5. The process of wherein an acylation catalyst is applied.6. The process of wherein the molar ratio between the fluoroformiate of formula (II) and the aldehyde of formula (III) is from 0.9:1 to 5:1.7. The process of wherein the reaction of the fluoroformiate of formula (II) and the aldehyde of formula (III) is performed at a temperature from 0° C. to 150° C.8. The process of wherein the fluoroformiate of formula (II) is prepared from carbonyl fluoride and an aldehyde of formula (IV) RCH(O) wherein Rhas the meaning given above.9. The process of wherein the 1 claim 8 ,1′-difluorodialkyl carbonate is manufactured from carbonyl fluoride and the aldehyde of formula (IV) in a 1-pot reaction.10. The process of wherein the reaction is performed in the presence of an acylation catalyst.11. The process of wherein the acylation catalyst is selected from the group consisting of tertiary amines.12. A racemate of bis-(R)-1-fluoroethyl carbonate and bis-(S)-1-fluoroethyl carbonate.13. (R)-1-fluoroethyl-(S)-1′-fluoroethyl carbonate.14. An electrolyte solvent for Li ion batteries ...

A Process for Manufacturing Isocyanates and/or Polycarbonates

A process for manufacturing isocyanates or polycarbonates comprising the steps of: providing a chlorine stream and carbon monoxide stream; reacting said chlorine stream and said carbon monoxide stream for providing a phosgene stream; cooling the phosgene stream to a temperature at which the phosgene in the phosgene stream is liquid, preferably, to a temperature that is 4° C. less or more than 4° C. less than the boiling point of phosgene, to form a liquid phosgene stream and a gas stream; separating the gas stream and the liquid phosgene stream; removing residual chlorine from the liquid phosgene stream to form a chlorine depleted phosgene stream and reacting the chlorine depleted phosgene stream to form an isocyanate or a polycarbonate.

PROCESS FOR MAKING MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR

The invention provides a process for the preparation of a compound of Formula 1, 158-. (canceled)60. The process of claim 59 , wherein PG is propoxy formyl claim 59 , methanesulfonyl claim 59 , 4-nitro-benzoyl claim 59 , ethoxy formyl claim 59 , butoxy formyl claim 59 , t-butoxy formyl claim 59 , i-propoxy formyl or methoxy formyl.61. The process of claim 60 , wherein PG is methoxy formyl.63. The process of claim 62 , wherein the solvent is diethyl ether claim 62 , or methylene chloride.64. The process of claim 63 , wherein the solvent is methylene chloride.67. The process of claim 66 , wherein the reaction is quenched by adding the reaction mixture to cold water.68. The process of claim 66 , wherein the aqueous layer is extracted with dichloromethane.69. The process of claim 68 , wherein the dichloromethane is further washed with water.70. The process of claim 66 , wherein the product is isolated by crystallization with hexane. This application is a continuation of PCT Application No. PCT/US2010/028069 filed Mar. 19, 2010, which claims the priority of U.S. Application No. 61/162,148 filed Mar. 20, 2009; U.S. Application No. 61/246,303 filed Sep. 28, 2009; and U.S. Application No. 61/248,565 filed Oct. 5, 2009, which are hereby incorporated by reference in their entirety.The present invention relates to a process for making modulators of cystic fibrosis transmembrane conductance regulator (“CFTR”).Cystic fibrosis (CF) is a recessive genetic disease that affects approximately 30,000 children and adults in the United States and approximately 30,000 children and adults in Europe. Despite progress in the treatment of CF, there is no cure.CF is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene that encodes an epithelial chloride ion channel responsible for aiding in the regulation of salt and water absorption and secretion in various tissues. Small molecule drugs, known as potentiators that increase the probability of CFTR channel ...

METHOD FOR THE PHOSGENATION OF COMPOUNDS COMPRISING HYDROXYL, THIOL, AMINO AND/OR FORMAMIDE GROUPS

A method of reacting a first compound with a second compound, wherein the first compound has a GHS hazard identification of GHS06 and is obtainable from the reaction of at least one first fluid precursor compound and one second fluid precursor compound and wherein the second compound is capable of a chemical reaction with the first compound is provided 1. A method of reacting a first compound with a second compound ,wherein the first compound has a GHS hazard identification of GHS06 and is obtainable from the reaction of at least one first fluid precursor compound and one second fluid precursor compoundand wherein the second compound is capable of a chemical reaction with the first compound,comprising:(I) providing a liquid phase containing the second compound in a reactor having an upper end and a lower end viewed in the direction of gravity; the lower end of the contact tube is immersed into the liquid phase containing the second compound and', 'a catalyst bed present in the contact tube is set up to catalyze the reaction between the first and second precursor compounds to give the first compound;, '(II) providing a contact tube having an upper end and a lower end in the reactor, wherein'}(III) introducing the first and second precursor compounds through the contact tube, with the first compound formed in the contact tube exiting from the lower end of the contact tube and coming into contact with liquid phase containing the second compound.2. The method as claimed in claim 1 , wherein the first compound is phosgene claim 1 , the first precursor compound is carbon monoxide claim 1 , the second precursor compound is chlorine claim 1 , the catalyst present in the catalyst bed is an activated carbon catalyst and the second compound is a compound containing one or more of hydroxyl claim 1 , thiol claim 1 , amino and/or formamide groups.3. The method as claimed in claim 2 , wherein the activated carbon catalyst has a BET surface area of ≧300 to ≦2000 m/g and a dof the ...

PRODUCTION METHOD OF ASYMMETRIC CHAIN CARBONATE

A method for producing an asymmetric chain carbonate by reacting an alcohol with a halocarbonate ester compound in the presence of a basic magnesium salt. 1. A composition comprising: {'br': None, 'sup': 1', '2, 'ROCOOR\u2003\u2003(3),'}, 'an asymmetric chain carbonate represented by Formula (3){'sup': 1', '2', '1, 'wherein, in Formula (3), Ris an organic group; and Ris an organic group different from R, and'} {'br': None, 'sup': 1', '1, 'ROCOOR\u2003\u2003(4),'}, 'at least one selected from the group consisting of symmetric chain carbonates represented by Formula (4){'sup': '1', 'wherein, in Formula (4), Ris as defined above; and'} {'br': None, 'sup': 2', '2, 'ROCOOR\u2003\u2003(5),'}, 'symmetric chain carbonates represented by Formula (5){'sup': '2', 'wherein, in Formula (5), Ris as defined above.'}2. A composition comprising: {'br': None, 'sup': 1', '2, 'ROCOOR\u2003\u2003(3),'}, 'an asymmetric chain carbonate represented by Formula (3){'sup': 1', '2', '1, 'wherein, in Formula (3), Ris an organic group; and Ris an organic group different from R, and'}water,the composition containing water in an amount of 100 ppm or less. This application is a continuation of U.S. application Ser. No. 15/774,829, filed May 9, 2018, which is a National Stage of International Application No. PCT/JP2016/084621, filed Nov. 22, 2016, which claims priority from Japanese Patent Application No. 2015-229018, filed Nov. 24, 2015, the disclosures of which are incorporated herein by reference in their respective entireties.The present invention relates to a method for producing an asymmetric chain carbonate. The present invention also relates to a composition containing an asymmetric carbonate.Patent Literature 1 reports production of methyl-2,2,2-trifluoroethyl carbonate with a yield of 46% by adding methyl chloroformate to a solution containing 2,2,2-trifluoroethanol, pyridine, and dichloromethane.Patent Literature 2 and Patent Literature 3 describe production of highly purified methyl-2,2, ...

METHOD FOR PRODUCING CARBONATES

In an embodiment, a method of producing carbonate can comprise: reacting a feed comprising carbon monoxide and chlorine in a tube of a reactor to produce a product composition comprising phosgene, wherein the tube has a particulate catalyst contained therein, wherein a thermally conductive material separate from the tube contacts at least a portion of the particulate catalyst, and wherein carbon tetrachloride is present in the product composition in an amount of 0 to 10 ppm by volume based on the volume of the phosgene; and reacting a monohydroxy compound with the phosgene to produce the carbonate. 1. A method of producing carbonate , comprising:reacting a feed comprising carbon monoxide and chlorine in a tube of a reactor to produce a product composition comprising phosgene, wherein the tube has a particulate catalyst contained therein, wherein a thermally conductive material separate from the tube contacts at least a portion of the particulate catalyst, and wherein carbon tetrachloride is present in the product composition in an amount of 0 to 10 ppm by volume based on the volume of the phosgene, wherein the reactor is capable of producing greater than or equal to 2,000 kilograms of the product composition per hour; andreacting a monohydroxy compound with the phosgene to produce the carbonate.2. The method of claim 1 , wherein the thermally conductive material provides a thermally conductive path between the particulate catalyst and the tube.3. The method of claim 1 , comprising the thermally conductive material in the form of a coating disposed on at least a portion of an exterior surface of the particulate catalyst claim 1 , or a portion of an exterior surface of agglomerates of the particulate catalyst claim 1 , or both.4. The method of claim 1 , comprising the thermally conductive material in the form of a thermally conductive claim 1 , 3-dimensional mesh claim 1 , optionally; and/or comprising the thermally conductive material in the form of a particulate ...

PRODUCTION METHOD OF ASYMMETRIC CHAIN CARBONATE

A method for producing an asymmetric chain carbonate by reacting an alcohol with a halocarbonate ester compound in the presence of a basic magnesium salt. 2. The production method according to claim 1 ,{'sup': '1', 'wherein Ris an alkyl group having no fluorine atom or an alkyl group having a fluorine atom, and'}{'sup': '2', 'Ris an alkyl group having no fluorine atom or an alkyl group having a fluorine atom.'}4. The production method according to claim 3 ,{'sup': '1', 'wherein Ris an alkyl group having no fluorine atom or an alkyl group having a fluorine atom, and'}{'sup': '2', 'Ris an alkyl group having no fluorine atom or an alkyl group having a fluorine atom.'}5. The production method according to claim 3 ,wherein the inorganic base is at least one selected from the group consisting of carbonates of alkali metals, hydroxides of alkali metals, oxides of magnesium, oxides of alkaline earth metals, hydroxides of magnesium, hydroxides of alkaline earth metals, carbonates of magnesium, carbonates of alkaline earth metals, acetates of magnesium, and acetates of alkaline earth metals.6. The production method according to claim 3 ,wherein the desiccant is at least one selected from the group consisting of neutral calcium salts, zeolite, silica gel, alumina, and activated carbon. The present invention relates to a method for producing an asymmetric chain carbonate. The present invention also relates to a composition containing an asymmetric carbonate.Patent Literature 1 reports production of methyl-2,2,2-trifluoroethyl carbonate with a yield of 46% by adding methyl chloroformate to a solution containing 2,2,2-trifluoroethanol, pyridine, and dichloromethane.Patent Literature 2 and Patent Literature 3 describe production of highly purified methyl-2,2,2-trifluoroethyl carbonate by mixing trifluoroethanol, pyridine, and triglyme, and dropwise adding methyl chlorocarbonate to the mixture to synthesize methyl-2,2,2-trifluoroethyl carbonate, followed by rectification to collect ...

METHOD FOR PHOSGENATING COMPOUNDS CONTAINING HYDROXYL, THIOL, AMINO AND/OR FORMAMIDE GROUPS

The invention relates to a method particularly for reacting phosgene with compounds that contain hydroxyl, thiol, amino and/or formamide groups, comprising the steps of: (I) providing a reactor which has a first reaction chamber () and a second reaction chamber (), the first and the second reaction chambers being separated from one another by means of a porous carbon membrane (); (II) providing carbon monoxide and chlorine in the first reaction chamber; and simultaneously (III) providing a compound containing hydroxyl, thiol, amino and/or formamide groups in the second reaction chamber. The porous carbon membrane is configured to catalyse the reaction of carbon monoxide and chlorine to obtain phosgene, and to allow this formed phosgene to pass into the second reaction chamber. The invention also relates to a reactor that is suitable for carrying out the claimed method. 1. A reactor for reaction of phosgene with one or more_compounds containing one or more hydroxyl , thiol , amino and/or formamide groups , comprising:a first reaction space and a second reaction space, wherein the first and second reaction spaces are separated from one another by a porous carbon membrane;anda catalyst for the reaction of phosgene with the compound containing hydroxyl, thiol, amino and/or formamide groups, arranged at least partly on the side of the porous carbon membrane facing the second reaction space.2. The reactor as claimed in claim 1 , wherein an open-cell foam is additionally present in the first reaction space.3. The reactor as claimed in claim 1 , wherein the reactor comprises a multitude of first reaction spaces surrounded by a common second reaction space. This is a Divisional Application of U.S. patent application Ser. No. 15/503,855, filed Aug. 17, 2015, which is a § 371 National Stage Application of PCT/EP2015/068811, filed Aug. 17, 2015, which claims priority to German Application No. 10 2014 111 902.9 filed Aug. 20, 2014. Each of these applications is incorporated by ...

BISCHLOROFORMATE COMPOSITION, BISCHLOROFORMATE COMPOSITION PRODUCTION METHOD, BISCHLOROFORMATE COMPOSITION-CONTAINING SOLUTION, POLYCARBONATE RESIN, POLYCARBONATE RESIN PRODUCTION METHOD, COATING LIQUID, ELECTROPHOTOGRAPHIC PHOTORECEPTOR, AND ELECTROPHOTOGRAPHIC DEVICE

A bischloroformate composition is represented by a formula (1) below, contains a plurality of Ar components, and has an average number of monomer units (m1), which is calculated by an expression (Numerical Expression 1) below, ranging from 1.0 to 1.99. The plurality of Ar components are each independently Aror Ar. The plurality of Ar components include at least one Arand at least one Ar. Aris a group represented by a formula (2) below. Aris a group represented by a formula (3) below. A molar composition ratio represented by Ar/(Ar+Ar) ranges from 45 mol % to 99 mol %. 3. The bischloroformate composition according to claim 2 , comprising:one type of the first bischloroformate compound; andone type of the second bischloroformate compound.5. The production method of the bischloroformate composition according to claim 4 , wherein an aliphatic tertiary amine is further used.6. The production method of the bischloroformate composition according to claim 4 , comprising:continuously reacting a solution with the phosgene compound in a micrometer-order fine flow path under the presence of the hydrophobic organic solvent, the solution being prepared by dissolving the bisphenol compound represented by the formula (4) and the biphenol compound represented by the formula (5) in an alkali solution.7. A bischloroformate-composition-containing solution comprising:{'claim-ref': {'@idref': 'CLM-00001', 'claim 1'}, 'the bischloroformate composition according to ; and'}a solvent.9. A production method of a polycarbonate resin claim 1 , wherein at least the bischloroformate composition according to claim 1 , an organic solvent claim 1 , an alkali solution claim 1 , and a dihydric phenol compound are used claim 1 , the method comprising mixing an organic layer and an aqueous layer to cause interfacial polycondensation.10. The production method of the polycarbonate resin according to claim 9 , wherein the organic solvent is an organic solvent that is substantially immiscible with water and ...

Two atom bridged dicarbonate compounds as internal donors in catalysts for polypropylene manufacture

A solid, hydrocarbon-insoluble, catalyst component useful in polymerizing olefins, said catalyst component containing magnesium, titanium, and halogen, and further containing an internal electron donor having a structure: [R 1 —O—C(O)—O—] x R 2 wherein R 1 is independently at each occurrence, an aliphatic or aromatic hydrocarbon, or substituted hydrocarbon group containing from 1 to 20 carbon atoms; x is 2-4; and R 2 is an aliphatic or aromatic hydrocarbon, or substituted hydrocarbon group containing from 1 to 20 carbon atoms, provided that there are 2 atoms in the shortest chain connecting a first R 1 —O—C(O)—O— group and a second R 1 —O—C(O)—O— group.

Two atom bridged dicarbonate compounds as internal donors in catalysts for polypropylene manufacture

A solid, hydrocarbon-insoluble, catalyst component useful in polymerizing olefins, said catalyst component containing magnesium, titanium, and halogen, and further containing an internal electron donor having a structure: [R 1 -O-C(O)-O-] x R 2 wherein R 1 is independently at each occurrence, an aliphatic or aromatic hydrocarbon, or substituted hydrocarbon group containing from 1 to 20 carbon atoms; x is 2-4; and R 2 is an aliphatic or aromatic hydrocarbon, or substituted hydrocarbon group containing from 1 to 20 carbon atoms, provided that there are 2 atoms in the shortest chain connecting a first R 1 O C(O)-O- group and a second R 1 -O-C(O)-O- group.

Efficient and selective chemical recycling of carbon dioxide to methanol, dimethyl ether and derived products

An efficient and environmentally beneficial method of recycling and producing methanol from varied sources of carbon dioxide including flue gases of fossil fuel burning powerplants, industrial exhaust gases or the atmosphere itself. Converting carbon dioxide by chemical or electrochemical reduction secondary treatment to produce essentially methanol, dimethyl ether and derived products.

Process for producing diaryl carbonate

A process for producing diaryl carbonate of the present invention comprises steps of: (1) a diaryl carbonate production step of subjecting an aromatic monohydroxy compound and phosgene to condensation reaction at a temperature of 80 to 180° C. in the presence of an aromatic nitrogen-containing heterocyclic compound catalyst to obtain the diaryl carbonate; (2) a purification step of removing impurities from a hydrogen chloride gas by-produced upon the condensation reaction; (3) a chlorine recovery step of recovering chlorine usable for the production of phosgene from the purified hydrogen chloride gas; and (4) a phosgene production step of reacting the recovered chlorine with carbon monoxide to obtain phosgene usable in the diaryl carbonate production step. Such a process for producing diaryl carbonate by reacting an aromatic monohydroxy compound with phosgene using a catalyst comprising an aromatic nitrogen-containing heterocyclic compound has merits that the diaryl carbonate can be produced in an industrially advantageous manner even at a high conversion rate, and the by-produced hydrogen chloride is converted into chlorine and then is used in phosgene production process.

Process for producing diaryl carbonate

Three and four atom bridged dicarbonate compounds as internal donors in catalysts for polypropylene manufacture

A solid, hydrocarbon-insoluble, catalyst component useful in polymerizing olefins, said catalyst component containing magnesium, titanium, and halogen, and further containing an internal electron donor having a structure: [R 1 —O—C(O)—O—] x R 2 wherein R 1 is independently at each occurrence, an aliphatic or aromatic hydrocarbon, or substituted hydrocarbon group containing from 1 to 20 carbon atoms; x is 2-4; and R 2 is an aliphatic or aromatic hydrocarbon, or substituted hydrocarbon group containing from 1 to 20 carbon atoms, provided that there are from 3 to 4 atoms in the shortest chain connecting a first R 1 —O—C(O)—O— group and a second R 1 —O—C(O)—O— group.

Three and four atom bridged dicarbonate compounds as internal donors in catalysts for polypropylene manufacture

A solid, hydrocarbon-insoluble, catalyst component useful in polymerizing olefins, said catalyst component containing magnesium, titanium, and halogen, and further containing an internal electron donor having a structure: [R1-O-C(O)-O-] x R 2 wherein R 1 is independently at each occurrence, an aliphatic or aromatic hydrocarbon, or substituted hydrocarbon group containing from 1 to 20 carbon atoms; x is 2-4; and R 2 is an aliphatic or aromatic hydrocarbon, or substituted hydrocarbon group containing from 1 to 20 carbon atoms, provided that there are from 3 to 4 atoms in the shortest chain connecting a first R 1 -O-C(O)-O- group and a second R 1 -O-C(O)-O- group.

Two atom bridged dicarbonate compounds as internal donors in catalysts for polypropylene manufacture

A solid, hydrocarbon-insoluble, catalyst component useful in polymerizing olefins, said catalyst component containing magnesium, titanium, and halogen, and further containing an internal electron donor having a structure: [R 1 —O—C(O)—O—] x R 2 wherein R 1 is independently at each occurrence, an aliphatic or aromatic hydrocarbon, or substituted hydrocarbon group containing from 1 to 20 carbon atoms; x is 2-4; and R 2 is an aliphatic or aromatic hydrocarbon, or substituted hydrocarbon group containing from 1 to 20 carbon atoms, provided that there are 2 atoms in the shortest chain connecting a first R 1 —O—C(O)—O— group and a second R 1 —O—C(O)—O— group.

Three and four atom bridged dicarbonate compounds as internal donors in catalysts for polypropylene manufacture

A solid, hydrocarbon-insoluble, catalyst component useful in polymerizing olefins, said catalyst component containing magnesium, titanium, and halogen, and further containing an internal electron donor having a structure: [R1-O-C(O)-O-]xR2 wherein R1 is independently at each occurrence, an aliphatic or aromatic hydrocarbon, or substituted hydrocarbon group containing from 1 to 20 carbon atoms; x is 2-4; and R2 is an aliphatic or aromatic hydrocarbon, or substituted hydrocarbon group containing from 1 to 20 carbon atoms, provided that there are from 3 to 4 atoms in the shortest chain connecting a first R1-O-C(O)-O- group and a second R1-O-C(O)-O- group.

Componente catalisador sólido insolúvel em hidrocarboneto, método para polimerizar uma olefina e composto

sistema de determinação de propriedade de combustível para motor de combustão interna. a presente invenção refere-se a uma pressão de injeção de combustível (per) em um tempo no qual uma concentração de nox (temperatura de combustão) indica um valor máximo, sob a condição que um tempo de injeção de combustível (injt) seja fixo a um primeiro tempo de injeção (int1) e seja gravado como uma primeira pressão de injeção de pico de nox (per1). similarmente, uma segunda pressão de injeção de pico de nox (pcr2) é gravada sob a condição que o tempo de injeção de combustível (injt) seja fixo a um segundo tempo de injeção (int2). um número de cetanos (cn) e uma propriedade de destilação (t90) do combustível são determinados com base nestas pressões de injeção de pico de nox (per1 e pcr2).

Compuestos de dicarbonato puenteados por dos atomos como donadores internos en catalizadores para la fabricacion de polipropileno.

Un componente catalizador sólido, insoluble en hidrocarburo, útil para polimerizar olefinas, dicho componente catalizador contiene magnesio, titanio, y halógeno, y contiene además un donador de electrones interno que tiene una estructura: [R1-O-C(O)O-]xR2 donde R1 es independientemente en cada incidencia, un hidrocarburo alifático o aromático, o grupo hidrocarburo sustituido con contenido de 1 a 20 átomos de carbono; x es 2-4; y R2 es un hidrocarburo alifático o aromático, o grupo hidrocarburo sustituido con contenido de 1 a 20 átomos de carbono, visto que existen 2 átomos en la cadena más corta que conectan con un primer grupo R1-O-C(O)-O y un segundo grupo R1- O-C(O)-O.

Preparation of chloroformate compounds

클로로포메이트 화합물을, 안전하고 또한 고수율로 대량 생산하는 방법을 제공한다. 클로로포메이트 화합물은, 트리포스겐의 용액, 아민, 알코올 화합물을, 플로우식 리액터 중에서 혼합하고, 반응시킴으로써 제조된다. 혹은 트리포스겐의 용액과, 아민 및 알코올 화합물의 용액을, 플로우식 리액터 중에서 혼합하고, 반응시킴으로써 제조된다. 상기 아민이 트리부틸아민인 것이 바람직하고, 상기 아민의 사용량이 상기 알코올 화합물에 대하여 0.8 내지 3당량인 것이 바람직하다. A method for mass production of a chloroformate compound safely and in high yield is provided. A chloroformate compound is produced by mixing and reacting a solution of triphosgene, an amine, and an alcohol compound in a flow reactor. Alternatively, a solution of triphosgene and a solution of an amine and alcohol compound are mixed in a flow reactor and reacted. It is preferable that the said amine is tributylamine, and it is preferable that the usage-amount of the said amine is 0.8-3 equivalent with respect to the said alcohol compound.

Patent JPS5440280B2

Method for producing a polycarbonate oligomer

Polycarbonate oligomer having uniform qualities is prepared by reacting an aqueous alkaline solution of 2,2-(4,4'-dihydroxydiphenyl) propane with phosgene in the presence of methylene chloride and as a characteristic point of this method, in the presence of an inert gas in an amount of 1 to 10 mol % based upon the phosgene.

디아릴 카르보네이트의 제조 방법

본 발명은 1종 이상의 촉매의 존재 하에 및 부가적 용매의 첨가 없이 용융된 모노히드록시 방향족 및 포스겐으로부터 디아릴 카르보네이트 및 기체상 염화수소를 제조하는 방법에 관한 것이며, 기체상 염화수소는 99.0 중량% 초과의 순도를 갖는다. 본 발명은 형성된 기체상 염화수소에 응축, 스크러빙 또는 증류를 포함한 군으로부터 선택되는 1종 이상의 정제 수단을 수행하여 부산물을 제거하는 것을 특징으로 한다.

Method for the preparation of aliphatic chloroformates

Method for the preparation of aromatic chloroformates

Three and four atom bridged dicarbonate compounds as internal donors in catalysts for polypropylene manufacture

A solid, hydrocarbon-insoluble, catalyst component useful in polymerizing olefins, said catalyst component containing magnesium, titanium, and halogen, and further containing an internal electron donor having a structure: [R1-O-C(O)-O-]xR2 wherein R1 is independently at each occurrence, an aliphatic or aromatic hydrocarbon, or substituted hydrocarbon group containing from 1 to 20 carbon atoms; x is 2-4; and R2 is an aliphatic or aromatic hydrocarbon, or substituted hydrocarbon group containing from 1 to 20 carbon atoms, provided that there are from 3 to 4 atoms in the shortest chain connecting a first R1-O-C(O)-O- group and a second R1-O-C(O)-O- group.

Two atom bridged dicarbonate compounds as internal donors in catalysts for polypropylene manufacture

Diatomic bridged dicarbonate compounds as internal donors in catalysts for the production of polypropylene

Two atom bridged dicarbonate compounds as internal donors in catalysts for polypropylene manufacture

본 발명은 마그네슘, 티타늄 및 할로겐을 함유하고 구조 (식 중, R 1 은 각 경우에 독립적으로 지방족 또는 방향족 탄화수소 또는 1 내지 20개의 탄소 원자를 함유하는 치환된 탄화수소 기이고; x는 2 내지 4이고; R 2 는 지방족 또는 방향족 탄화수소 또는 1 내지 20개의 탄소 원자를 함유하는 치환된 탄화수소 기이되, 단 제1 R 1 -O-C(O)-O- 기 및 제2 R 1 -O-C(O)-O- 기를 연결하는 최단 쇄에 2개의 원자가 존재함)를 갖는 내부 전자 공여체를 추가로 함유하는, 올레핀 중합에 유용한 고체의 탄화수소-불용성 촉매 성분에 관한 것이다. The present invention relates to a composition containing magnesium, titanium and a halogen, Wherein R 1 is independently in each occurrence an aliphatic or aromatic hydrocarbon or a substituted hydrocarbon group containing from 1 to 20 carbon atoms, x is from 2 to 4, R 2 is an aliphatic or aromatic hydrocarbon, or from 1 to 20 being one substituted hydrocarbon odd containing carbon atoms, with the proviso of claim 1 R 1 -OC (O) -O- group and a 2 R 1 -OC (O) is present two atoms in the shortest chain linking -O- groups Insoluble &lt; / RTI &gt; catalyst component of a solid useful for olefin polymerization.

作为用于聚丙烯制造的催化剂中的内部给体的两个原子桥接的二碳酸酯化合物

可用于聚合烯烃的不溶于烃的固体催化剂组分，所述催化剂组分含有镁、钛、和卤素，并进一步含有具有以下结构的内部电子给体：[R 1 -O-C(O)-O-] x R 2 其中R 1 在各出现处独立地为含有1~20个碳原子的脂族或芳族烃，或取代的烃基；x为2-4；以及R 2 为含有1~20个碳原子的脂族或芳族烃，或取代的烃基，条件是在连接第一R 1 -O-C(O)-O-基团和第二R 1 -O-C(O)-O-基团的最短链中有2个原子。

Solid catalyst component insoluble in hydrocarbon and method for polymerizing an olefin

componente catalisador sólido insolúvel em hidrocarboneto, método para polimerizar uma olefina e composto um componente de catalisador sólido insolúvel em hidrocarboneto, útil na polimerização de olefinas, dito componente de catalisador contendo magnésio, titânio e halogênio, e contendo ainda um doador de elétrons interno com a estrutura: [r1-0-c(o)-o-jxr2 , onde r1 é independentemente, em cada ocorrência, um hidrocarboneto alifático ou aromático, ou grupo hidrocarboneto substituído de 1 a 20 átomos de carbono; x é 2-4; e r2 é um hidrocarboneto alifático ou aromático, ou grupo hidrocarboneto substituído contendo de 1 a 20 átomos de carbono, contanto que existam de 2 átomos na cadeia mais curta que conecta um primeiro grupo r1-0-c (o) -0- e um segundo grupo r1-0-c(0)-0-. hydrocarbon insoluble solid catalyst component, method for polymerizing an olefin and compound a hydrocarbon insoluble solid catalyst component, useful in the polymerization of olefins, said catalyst component containing magnesium, titanium and halogen, and also containing an internal electron donor with structure: [r1-0-c (o) -o-jxr2, where r1 is independently, at each occurrence, an aliphatic or aromatic hydrocarbon, or substituted hydrocarbon group of 1 to 20 carbon atoms; x is 2-4; and r2 is an aliphatic or aromatic hydrocarbon, or substituted hydrocarbon group containing from 1 to 20 carbon atoms, as long as there are 2 atoms in the shortest chain that connects a first group r1-0-c (o) -0- and a second group r1-0-c (0) -0-.

Two atom bridged dicarbonate compounds as internal donors in catalysts for polypropylene manufacture

A solid, hydrocarbon-insoluble, catalyst component useful in polymerizing olefins, said catalyst component containing magnesium, titanium, and halogen, and further containing an internal electron donor having a structure: [R1-O -C(O)- O-]xR2 wherein R1 is independently at each occurrence, an aliphatic or aromatic hydrocarbon, or substituted hydrocarbon group containing from 1 to 20 carbon atoms; x is 2-4; and R2 is an aliphatic or aromatic hydrocarbon, or substituted hydrocarbon group containing from 1 to 20 carbon atoms, provided that there are 2 atoms in the shortest chain connecting a first R1 O C(O)-O- group and a second Ri-O-C(O)-O- group.

Dicarbonate compounds with two bridging atoms as internal donors in catalysts for polypropylene production

FIELD: chemistry. SUBSTANCE: invention relates to solid hydrocarbon-insoluble component of catalyst for olefin polymerisation and to method of polymerisation in presence of said catalyst component. Catalyst component contains magnesium, titanium, halogen and additionally internal donor of electrons, which has structure [R 1 -O-C(O)-O-] x R 2 , where R 1 independently in each case represents aliphatic or aromatic hydrocarbon or substituted hydrocarbon group, containing from 1 to 20 carbon atoms; x equals 2-4; R 2 represents aliphatic or aromatic hydrocarbon or substituted hydrocarbon group, containing from 1 to 20 carbon atoms, on condition that in the shortest chain, connecting first R 1 -O-C(O)-O- group and second R 1 -O-C(O)-O- group, 2 atoms are contained. EFFECT: high efficiency of catalyst work and obtaining polymer with improved and various properties. 14 cl, 4 tbl, 13 ex РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 2 576 519 C2 (51) МПК C08F 4/651 (2006.01) B01J 31/02 (2006.01) C08F 110/06 (2006.01) C08F 4/646 (2006.01) C07C 69/96 (2006.01) C07C 68/00 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ОПИСАНИЕ (21)(22) Заявка: ИЗОБРЕТЕНИЯ К ПАТЕНТУ 2012127352/04, 30.11.2010 (24) Дата начала отсчета срока действия патента: 30.11.2010 Приоритет(ы): (30) Конвенционный приоритет: (72) Автор(ы): КОУЛТЕР Джозеф Н. III (US), ЛЕУНГ Так В. (US), ТАО Тао (US), ГАО Куаньцян (US) (43) Дата публикации заявки: 10.01.2014 Бюл. № 1 R U (73) Патентообладатель(и): У.Р.ГРЕЙС ЭНД КО.-КОНН. (US) 02.12.2009 US 61/265,931 (45) Опубликовано: 10.03.2016 Бюл. № 7 C 2 C 2 (85) Дата начала рассмотрения заявки PCT на национальной фазе: 02.07.2012 (86) Заявка PCT: 2 5 7 6 5 1 9 US 2010/058262 (30.11.2010) R U 2 5 7 6 5 1 9 (56) Список документов, цитированных в отчете о поиске: US 20080103191 A1, 01.05.2008. US 20050244746 A1, 03.11.2005. Eugen Muller et al. Stabile ortho-Semichinonsalze, Justus liebigs annalen der chemie, Verlag chemie GMBH, Weinheim, DE, vol. 688, 1 January ...

Two atom bridged dicarbonate compounds as internal donors in catalysts for polypropylene manufacture

A solid, hydrocarbon-insoluble, catalyst component useful in polymerizing olefins, said catalyst component containing magnesium, titanium, and halogen, and further containing an internal electron donor having a structure: [R1-O-C(O)-O-]xR2 wherein R1 is independently at each occurrence, an aliphatic or aromatic hydrocarbon, or substituted hydrocarbon group containing from 1 to 20 carbon atoms; x is 2-4; and R2 is an aliphatic or aromatic hydrocarbon, or substituted hydrocarbon group containing from 1 to 20 carbon atoms, provided that there are 2 atoms in the shortest chain connecting a first R1 O C(O)-O- group and a second R1-O-C(O)-O- group.

Two atom bridged dicarbonate compounds as internal donors in catalysts for polypropylene manufacture

A solid, hydrocarbon-insoluble, catalyst component useful in polymerizing olefins, said catalyst component containing magnesium, titanium, and halogen, and further containing an internal electron donor having a structure: [R 1 -O-C(O)-O-] x R 2 wherein R 1 is independently at each occurrence, an aliphatic or aromatic hydrocarbon, or substituted hydrocarbon group containing from 1 to 20 carbon atoms; x is 2-4; and R 2 is an aliphatic or aromatic hydrocarbon, or substituted hydrocarbon group containing from 1 to 20 carbon atoms, provided that there are 2 atoms in the shortest chain connecting a first R 1 O C(O)-O- group and a second R 1 -O-C(O)-O- group.

作为用于聚丙烯制造的催化剂中的内部给体的两个原子桥接的二碳酸酯化合物

可用于聚合烯烃的不溶于烃的固体催化剂组分，所述催化剂组分含有镁、钛、和卤素，并进一步含有具有以下结构的内部电子给体：[R 1 -O-C(O)-O-] x R 2 其中R 1 在各出现处独立地为含有1~20个碳原子的脂族或芳族烃，或取代的烃基；x为2-4；以及R 2 为含有1~20个碳原子的脂族或芳族烃，或取代的烃基，条件是在连接第一R 1 -O-C(O)-O-基团和第二R 1 -O-C(O)-O-基团的最短链中有2个原子。

hydrocarbon insoluble solid catalyst component to polymerize an olefin and compound

Three and four atom bridged dicarbonate compounds as internal donors in catalysts for polypropylene manufacture

2-氯-3-甲基苯甲酸及其中间体的制备方法

本发明公开了一种2‑氯‑3‑甲基苯甲酸及其中间体的制备方法。一种2‑氯‑3‑甲基苯甲酸及其中间体的制备方法，包含以下步骤，在氧气压力为0.1MPa～0.8MPa的条件下，催化剂和助催化剂的作用下，将2,6‑二甲基氯苯进行氧化反应，即可；其中，所述2,6‑二甲基氯苯与所述氧气的摩尔用量比为1:1.8～1:2.2。该2‑氯‑3‑甲基苯甲酸的制备方法，以工业上较易购得的原料进行反应，后处理简单、产率高、纯度好、对环境污染小，更适合工业化。

Atp-binding casette transporter modulators

FIELD: chemistry. SUBSTANCE: novel compound is N-(5-hydroxy-2,4-di-tert-butylphenyl)-4-oxo-1H-quinoline-3-carboxamide or its pharmaceutically acceptable salts. The invention also relates to a pharmaceutical composition. EFFECT: obtaining a novel biologically active compound with CFTR activity modulation properties. 2 cl, 485 ex, 3 tbl (19) РОССИЙСКАЯ ФЕДЕРАЦИЯ RU (11) (51) МПК C07D C07D C07D C07D C07D C07D ФЕДЕРАЛЬНАЯ СЛУЖБА C07D ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ, C07D ПАТЕНТАМ И ТОВАРНЫМ ЗНАКАМ C07D A61K (12) ОПИСАНИЕ 2 382 779 401/12 (2006.01) 215/56 (2006.01) 209/12 (2006.01) 209/14 (2006.01) 209/18 (2006.01) 405/12 (2006.01) 409/12 (2006.01) 413/12 (2006.01) 417/12 (2006.01) 31/47 (2006.01) (13) C2 A61K 31/4709 (2006.01) A61P 25/00 (2006.01) A61P 31/00 (2006.01) ИЗОБРЕТЕНИЯ К ПАТЕНТУ (21), (22) Заявка: 2007102578/04, 24.06.2005 (24) Дата начала отсчета срока действия патента: 24.06.2005 (43) Дата публикации заявки: 27.07.2008 2 3 8 2 7 7 9 R U (56) Список документов, цитированных в отчете о поиске: WO 01/34570 А, 17.05.2001. US 4786644 А, 22.11.1988. Т.VAN ES ET AL, SOUTH AFRICAN JOURNAL OF CHEMISTRY, vol.54, 2001, pages 102-117. I.M.HEILBRONN ET AL, JOURNAL OF THE CHEMICAL SOCIETY, 1928, pages 934-941. K.GROHE ET AL, LIEBIGS ANNALEN DER CHEMIE, 1987, pages 871-879. Y.ITO ET AL, NEUROPHARMACOLOGY, vol.35, no.9/10, 1996, pages 1263-1269. (см. прод.) C 2 C 2 (45) Опубликовано: 27.02.2010 Бюл. № 6 (85) Дата перевода заявки PCT на национальную фазу: 24.01.2007 (86) Заявка PCT: US 2005/022768 (24.06.2005) (87) Публикация PCT: WO 2006/002421 (05.01.2006) Адрес для переписки: 129090, Москва, ул. Б.Спасская, 25, стр.3, ООО "Юридическая фирма Городисский и Партнеры", пат.пов. Е.Е.Назиной (54) МОДУЛЯТОРЫ ТРАНСПОРТЕРОВ АТФ-СВЯЗЫВАЮЩЕЙ КАССЕТЫ (57) Реферат: Изобретение соединению, относится к представляющего N-(5-гидрокси-2,4-ди-трет-бутилфенил)4-оксо-1Н-хинолин-3-карбоксамид, или к его фармацевтически приемлемым солям. новому собой Ñòð.: 1 ru 2 3 8 2 7 7 9 (73) ...

불소화 디알킬 카보네이트의 제조 방법

본 발명은 불소화 디알킬 카보네이트의 제조방법에 관한 것으로서, 더욱 상세하게는 이미다졸 유도체 존재하에 불소를 함유하는 알코올과 클로로포메이트 유도체를 반응시켜 불소화 디알킬 카보네이트를 제조함으로써, 유독성 원료를 사용하지 않으면서 온화한 조건에서 높은 수율로 불소화 디알킬 카보네이트를 제조할 수 있으며 불순물의 분리가 용이하도록 개선된 불소화 디알킬 카보네이트의 제조방법에 관한 것이다. 디알킬 카보네이트, 불소화, 이미다졸 화합물

Atp－结合弹夹转运蛋白的调控剂

本发明涉及ATP－结合弹夹(“ABC”)转运蛋白或其片段的调控剂、包括囊性纤维化跨膜电导调节剂、其组合物和与之有关的方法。本发明也涉及使用这类调控剂治疗ABC转运蛋白介导的疾病的方法。

Process for purification of diphenyl carbonate for the manufacturing of high quality polycarbonate

디아릴 카보네이트의 정제 방법은 수성 스트림을 금속 오염물을 포함하는 디아릴 카보네이트 스트림에 도입하는 단계로서, 상기 수성 스트림은 상기 금속 오염물과 반응하여 침전물을 형성하고; 상기 수성 스트림을 상기 디아릴 카보네이트 스트림에 도입하는 단계는 상기 디아릴 카보네이트 스트림 및 상기 수성 스트림의 총 조성물을 기준으로 물 100 내지 10,000 ppm을 도입하는 단계를 낳는 단계; 상기 침전물을 분리 컬럼 및 필터 중 하나 또는 둘 다를 통해 제거하여 정제된 디아릴 카보네이트를 생성하는 단계를 포함한다. A process for purifying diaryl carbonates comprises introducing an aqueous stream into a diaryl carbonate stream comprising metal contaminants, the aqueous stream reacting with the metal contaminants to form a precipitate; Introducing the aqueous stream into the diaryl carbonate stream results in introducing 100 to 10,000 ppm water based on the diaryl carbonate stream and the total composition of the aqueous stream; Removing the precipitate through one or both of a separation column and a filter to produce purified diaryl carbonate.

Ibuprofen ester derivative and emulsion preparation thereof

本申请涉及一种布洛芬酯衍生物及其乳状制剂。本申请通过对消旋布洛芬或S‑布洛芬的羧基进行衍生化，得到化合物N9及其右旋对映异构体N9(S)，并进一步将其制成乳状制剂，克服了现有布洛芬/右布洛芬注射液临床应用中存在的一些安全性和患者顺应性问题，达到了降低血管刺激性、增加临床使用方法、提高临床应用中制剂稳定性等目的。

Method of producing diaryl carbonate

FIELD: chemistry. SUBSTANCE: invention relates to a method of producing diaryl carbonate coupled with electrolysis of the formed alkali metal chloride-containing spent aqueous solutions. The method of producing diaryl carbonate and treating at least a portion of the formed alkali metal chloride-containing solution comprises the following steps: a) reacting phosgene, obtained from reacting chlorine with carbon monoxide, with at least one monophenol in the presence of a base and, optionally, in the presence of a base catalyst to form diaryl carbonate and an alkali metal chloride-containing solution, b) separating and extracting the diaryl carbonate formed at step (a), c) separating the alkali metal chloride-containing solution remaining after step (b) from solvent residue and, optionally, catalyst residue with subsequent treatment with adsorbents, wherein before treatment with adsorbents, pH of the alkali metal chloride-containing solution is set equal to or lower than 8, d) electrochemical oxidation of at least a portion of the alkali metal chloride-containing solution from step (c), which takes place with formation of chlorine, an alkali metal hydroxide solution and in the corresponding case hydrogen, wherein at least a portion of the obtained chlorine is used to produce phosgene and/or e) returning at least a portion of the alkali metal hydroxide solution obtained at step (d) to step (a) for producing diaryl carbonate, where at least a portion of the alkali metal chloride-containing solution formed at step (c) is returned to step (a). EFFECT: along with other advantages, the disclosed method improves recycling through electrolysis of the alkali metal chloride-containing solution formed when producing diaryl carbonate. 12 cl, 4 ex РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) 2 496 765 (51) МПК C07C C07C C02F C02F C07C C25B ФЕДЕРАЛЬНАЯ СЛУЖБА C01D ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ C01D C25B C01B (12) ОПИСАНИЕ 68/06 68/02 1/28 1/461 69/96 1/46 3/04 3/06 1/34 31/28 (2006.01) ( ...

ATP-binding cassette transporter modulator

Three and four atom-bridged dicarbonate compounds as internal donors in catalysts for producing polypropylene

FIELD: chemistry. SUBSTANCE: catalyst component contains magnesium, titanium and a halogen and additionally contains an internal electron donor, having the structure [R 1 -O-C(O)-O-] x R 2 , where R 1 independently in each case represents an aliphatic or aromatic hydrocarbon or a substituted hydrocarbon group containing 1-20 carbon atoms; x equals 2-4 and R 2 represents an aliphatic or aromatic hydrocarbon or a substituted hydrocarbon group containing 1-20 carbon atoms, under the condition that the shortest chain linking the first R 1 -O-C(O)-O-group and the second R 1 -O-C(O)-O-group contains 3-4 atoms. A method of polymerising olefins is carried out in the presence of the said component. The compound has the structure [R 1 -O-C(O)-O-] x R 2 , where R 1 independently in each case represents an aliphatic or aromatic hydrocarbon or a substituted hydrocarbon group containing 1-20 carbon atoms, x equals 2-4 and R 2 represents a 1,8-disubstituted naphthalene moiety. EFFECT: said internal donors provide high catalytic activity and high hydrogen response during polymerisation, and enable to obtain propylene-based polymers with high isotacticity, commonly expressed as a xylene soluble fraction and/or final melting temperature. 15 cl, 5 tbl РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 2 580 831 C2 (51) МПК C08F 4/651 (2006.01) B01J 31/02 (2006.01) C08F 110/06 (2006.01) C08F 4/646 (2006.01) C07C 69/96 (2006.01) C07C 68/00 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ОПИСАНИЕ (21)(22) Заявка: ИЗОБРЕТЕНИЯ К ПАТЕНТУ 2012127354/04, 30.11.2010 (24) Дата начала отсчета срока действия патента: 30.11.2010 Приоритет(ы): (30) Конвенционный приоритет: (72) Автор(ы): КОЛУТЕР III Джозеф Н. (US), ЛЕУНГ Так В. (US), ТАО Тао (US), ГАО Куаньцян (US) (43) Дата публикации заявки: 10.01.2014 Бюл. № 1 R U (73) Патентообладатель(и): У.Р.ГРЕЙС ЭНД КО.-КОНН. (US) 02.12.2009 US 61/265,934 (45) Опубликовано: 10.04.2016 Бюл. № 10 2 5 8 0 8 3 1 (85) Дата начала рассмотрения заявки PCT ...

Method of producing alpha-chlorinated chlorformiates

1. СПОСОБ ПОЛУЧЕНИЯ ni -ХЛО РИРОВАННЫХ ХЛОРФОРМИАТОВ общей К-(СН-0-С-С1)ш Iи С1 о где R - метил, изопропил, бутил, изобутил, винил, CCIj, CBtj, , где X - 2-С1, 4-СНО, циклогексен-3-ил, 2-хлорЭТШ1 , то 1-2, взаимодействием фосгена с альдегидом общей формулы R(CHO), где значение R и m указано вьте, в присутствии катализатора, отличающийс  тем, что, с целью повышени  выхода и расширени  ассортимента целевых продуктов, в качестве катализатора используют соединени , выбранные из группы: пиридин, N,Ы-диметиланилин,N,Ы-диметиламинопиридин ,имидазол,тетраметилмочевина,тетрабутилмочевина , хлористый тетра-н-бутиламмоний - продукт реакции тетрабутнлмочевины с фосгеном, хлористый три-н-бутилбензиламмоний, хлористый тетра-н-бутиламмоний, триоктилфосфин, гексаметилфосфотриамид , диметилформамид, ди(п-диметипаминофенил )кетон, тетра-н-гексиламСО монийбромид, КС1 + криптофикс 1. METHOD OF OBTAINING ni-CHLOROUS RANATED CHLORFORMIATS of total K- (CH-0-C-C1) w I and C1 o where R is methyl, isopropyl, butyl, isobutyl, vinyl, CCIj, CBtj, where X is 2-C1, 4-CHO, cyclohexen-3-yl, 2-chloro ELN1, then 1-2, by reacting phosgene with an aldehyde of the general formula R (CHO), where the value of R and m is indicated, in the presence of a catalyst, characterized in that output and expansion of the range of target products, as the catalyst used compounds selected from the group: pyridine, N, N-dimethylaniline, N, N-dimethylaminopyridine, imidazole, tetramethylurea, tet abutylurea, tetra-ni KC1 + cryptofix

Modulators of ATP-binding cassette transporters

本发明涉及ATP-结合弹夹(“ABC”)转运蛋白或其片段的调控剂、包括囊性纤维化跨膜电导调节剂、其组合物和与之有关的方法。本发明也涉及使用这类调控剂治疗ABC转运蛋白介导的疾病的方法。

A kind of chloromethyl butylperoxyisopropyl carbonate continuous reacting device and method

本发明涉及一种氯甲基异丙基碳酸酯反应装置及方法，是一种将氯甲酸氯甲酯和异丙醇反应生产氯甲基异丙基碳酸酯的多级全混釜和连续反应精馏塔组合的连续化反应装置。该反应装置的特点是首先从储罐连续将氯甲酸氯甲酯和异丙醇混合后进入串联的多级反应釜中，在反应的同时抽走氯化氢，在多级反应釜反应完成后将物料泵送入精馏塔中，通过再沸器的加热将氯化氢脱除干净，在塔釜达到反应平衡后去精馏装置得到成品。塔顶的氯化氢气体通过冷凝脱除异丙醇后进入真空泵中，被真空泵脱除后去氯化氢吸收工段得到盐酸。

Modulators of atp-binding cassette transporters

The present invention relates to a compound of formula I: (see formula I) wherein R1, R2, R3, R4, R5, R6, R7 and Ar1 are as described herein, and which may be used as modulators of ATP-Binding Cassette ("ABC") transporteres or fragments thereof.

Process for making modulators of cystic fibrosis transmembrane conductance regulator

Method of obtaining modulators of cystic fibrousis transmembrane conductance regulator

FIELD: chemistry. SUBSTANCE: invention relates to field of organic chemistry, namely to method of obtaining compound of formula 1, including condensation of carboxylic acid of formula 2 with aniline of formula 3 in presence of TZR®, where each R 2 and R 4 independently represents C 1-6 alkyl with linear or branched chain, and each C 1-6 alkyl with linear or branched chain is independently and optionally substituted with -OR'; each R 5 represents OC(O)OR' or R 4 and R 5 , taken together, form group , y represents 0, each R' represents C 1-4 alkyl group, optionally substituted with one or more groups, selected from oxo and -O-C 1-4 -alkyl group. Invention also relates to intermediate compounds and methods of their obtaining. EFFECT: elaborated is novel method of obtaining formula 1 compound, which can be useful as modulator of cystic fibrosis transmembrane conductance regulator (CFTR). 52 cl, 10 ex РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 2 543 714 C2 (51) МПК C07D 215/233 (2006.01) C07D 307/87 (2006.01) C07C 209/36 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ОПИСАНИЕ (21)(22) Заявка: ИЗОБРЕТЕНИЯ К ПАТЕНТУ 2011142295/04, 19.03.2010 (24) Дата начала отсчета срока действия патента: 19.03.2010 Приоритет(ы): (30) Конвенционный приоритет: (43) Дата публикации заявки: 27.04.2013 Бюл. № 23 2 5 4 3 7 1 4 R U Paritala, H. et al: "Benzo(h)quinoline derivatives as G-quadruplex binding agents", Bioorganic & Medicinal Chemistry Letters, 19(6), 2009, pp.1584-1587 . WO 2009/036412 A1, 19.03.2009. WO 2006002421 A2, 05.01.2006. Wentland M.P. et al: "Mammalian topoisomerase II inhibitory activity of (см. прод.) (73) Патентообладатель(и): ВЕРТЕКС ФАРМАСЬЮТИКАЛЗ ИНКОРПОРЕЙТЕД (US) (85) Дата начала рассмотрения заявки PCT на национальной фазе: 20.10.2011 (86) Заявка PCT: US 2010/028069 (19.03.2010) (87) Публикация заявки PCT: WO 2010/108162 (23.09.2010) Адрес для переписки: 129090, Москва, ул. Большая Спасская, 25, стр. 3, ООО "Юридическая фирма " ...

Efficient and selective conversion of carbon dioxide to methanol, dimethyl ether and derived products

CA-4 carbonates derivative, its preparation method, pharmaceutical composition and medicinal use

本发明涉及CA-4碳酸酯类衍生物、其制备方法、药物组合物与医药用途。所述CA-4碳酸酯类衍生物是具有通式6的化合物，是CA-4分子中的酚羟基被氯甲酸酯酯化后而制得的一类侧链含有烷基酯基的CA-4酯类衍生物。本发明还提供该CA-4碳酸酯类衍生物的制备方法和药物组合物。所述CA-4碳酸酯类衍生物用于制备抗肿瘤药物，特别是在抗人乳腺癌或白血病药物中的应用。

Method for producing modulators of cystic fibrosis membrane conductance regulators

Preparing (co)polycarbonate or diaryl carbonate, useful in e.g. sunglasses, comprises converting di-, mono-phenol and phosgene to chloroformic acid aryl ester, oligo- or diaryl-carbonate, and reacting the product under alkaline solution

Continuously preparing polycarbonate or copolycarbonate and/or diaryl carbonate comprises (a) continuously producing a mixture of an organic phase containing a solvent suitable for the polycarbonate and/or diaryl carbonate, and aqueous phase containing a solvent suitable for diphenol, monophenol, water and alkaline solution; (b) converting the diphenol, monophenol and phosgene to oligocarbonate and/or chloroformic acid aryl ester and/or diaryl carbonate; and (c) reacting an oligocarbonate, chloroformic acid aryl ester and/or diaryl carbonate under the addition of alkaline solution. Continuous preparation of polycarbonate or copolycarbonate and/or diaryl carbonate after the interfacial phase process of at least a diphenol and/or monophenol, phosgene and at least a catalyst optionally in the presence of at least a chain breaker and/or brancher, comprises (a) continuously producing a mixture of an organic and aqueous phase, where the organic phase contains at least a solvent suitable for the polycarbonate and/or diaryl carbonate and the phosgene and the aqueous phase contains the diphenol, monophenol, water and alkaline solution; (b) converting the diphenol, monophenol and phosgene to oligocarbonate and/or chloroformic acid aryl ester and/or diaryl carbonate; and (c) subsequently reacting an oligocarbonate, chloroformic acid aryl ester and/or diaryl carbonate in at least a reactor under the addition of further alkaline solution, optionally chain breaker and optionally at least a further catalyst, where: the steps (a) and (b) takes place in one or more pump(s), which have at least an inlet for the organic and aqueous phase and optionally further inlet for catalyst, chain breaker, brancher and/or alkali solution, respectively, and at least an outlet for the oligocarbon containing and/or chloroformic acid aryl ester-diaryl carbonate mixture; and the pump has thermostatic temperature and operates in stator-rotor principle.

Method for making polycarbonates

Mono carbonylation of Benzene diols

본 발명은 정밀화학 산업에서 널리 유용한 하기 화학식(II)의 벤젠 디올의 모노카르보닐화 방법에 관한 것으로 화학식(II)의 벤젠 디올을 무수산 혹은 카르보닐할라이드를 이용하여 고 수율로 모노카르보닐화 벤젠 디올을 제조하는 방법이다. 특히 염기를 사용하지 않는 것을 특징으로 한다 . The present invention relates to a monocarbonylation method of benzene diol of formula (II), which is widely used in the fine chemical industry, and to monocarbonylation of benzene diol of formula (II) with anhydrous acid or carbonyl halide in high yield. It is a method for preparing benzene diol. In particular, no base is used. 상기식에서, R은 수소 또는 탄소수 1 내지 15의 알킬기, 사이클로알킬기, 아릴기, 알콕시, 아릴옥시, 디알킬아미노기, 알킬아릴아미노기, 또는 디아릴아미노기를 나타내며, X는 일반적인 이탈기를 의미한다. Wherein R represents hydrogen or an alkyl group having 1 to 15 carbon atoms, a cycloalkyl group, an aryl group, an alkoxy, aryloxy, dialkylamino group, alkylarylamino group, or diarylamino group, and X means a general leaving group. R은 바람직하게는 수소 또는 탄소수 1 내지 15의 알킬기, 탄소수 3 내지 7의 사이클로알킬기, 페닐기, 탄소 수 1 내지 4의 알콕시, 페닐옥시, (C 1 -C 4 )디알킬아미노기, (C 1 -C 4 )알킬페닐아미노기, 또는 디페닐아미노기이고 X는 바람직하게는 염소, 아세톡시 등의 이탈기이다. R is preferably hydrogen or an alkyl group having 1 to 15 carbon atoms, a cycloalkyl group having 3 to 7 carbon atoms, a phenyl group, an alkoxy having 1 to 4 carbon atoms, phenyloxy, a (C 1 -C 4 ) dialkylamino group, (C 1- C 4 ) alkylphenylamino group or diphenylamino group, and X is preferably a leaving group such as chlorine, acetoxy or the like.

Method of obtaining chlorine fomiate of s1-c2 alkyl esters of c1-c2-c-alkyltartronic acid

Chloroformates of alkyl esters of C-alkyl or C-haloalkyl tartronic acids of the general formula: <IMAGE> in which: R represents an alkyl or haloalkyl group having from 1 to 5 carbon atoms, and R1 represents an alkyl group having from 1 to 5 carbon atoms, may be prepared by reaction of phosgene in an inert solvent with the corresponding ester of the C-alkyl-tartronic acid of the desired compound at a temperature of from 0 DEG to 20 DEG C. in the presence of at least a stoichiometric amount of a tertiary amine.

Method for the preparation of aliphatic chloroformates

一种制备脂族氯甲酸酯的方法，它包括，将至少一种脂族羟基化合物、光气、至少一种溶剂和任选至少一种有机碱的混合物引入流动反应器，以得到单向流动反应混合物。维持该单向流动反应混合物在约0℃－约60℃，以产生含有用于聚碳酸酯和共聚碳酸酯的制备的脂族氯甲酸酯的单一产物流。

Method of producing diaryl carbonate and processing at least one portion of resultant solution containing alkali metal chloride in alkali metal chloride electrolysis cell down processing chain

FIELD: chemistry. SUBSTANCE: invention relates to a method of producing diaryl carbonate and processing at least a portion of the resultant solution which contains an alkali metal chloride in an alkali metal chloride electrolysis cell down the process chain, which involves the following steps: a) obtaining phosgene by reacting chlorine with carbon monoxide, b) reacting phosgene formed at step a) with at least one monophenol in the presence of a base, optionally a base catalyst, to diarylcarbonate and a solution which contains an alkali metal chloride, c) separating the organic phase which contains the diaryl carbonate formed at step b) and at least one-time washing of the organic phase containing diaryl carbonate, d) separating the solution which contains the alkali metal chloride remaining in accordance with step c) from solvent residue and, optionally, catalyst residue by stripping the solution with water vapour and treating with adsorbents, e) electrochemical oxidation of at least a portion of the solution which contains an alkali metal chloride from step d) to form chlorine, an alkali and, optionally, hydrogen, where during separation d) of the solution before treatment with adsorbents, the pH of the solution is set below or equal to 8 and f) at least a portion of the chlorine obtained according to step e) is returned to producing phosgene according to step a) and/or g) at least a portion of the obtained alkali solution obtained according to step e) is returned to producing diaryl carbonate according to step b). EFFECT: method enables to obtain an end product with high purity and high output while cutting environmental contamination and solving the problem of waste water. 20 cl, 6 ex РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) 2 484 082 (13) C2 (51) МПК C07C C02F C02F C07C C25B C01D C01D ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ C25B C01B C25B (12) ОПИСАНИЕ 68/02 1/28 1/461 69/96 1/46 3/04 3/06 1/34 31/28 1/26 (2006.01) (2006.01) (2006.01) (2006.01) (2006.01) ( ...

Method for starting up and shutting down a phosgene generator

본 발명은 일산화탄소와 염소를 반응 챔버에 배열된 활성탄 촉매 상에서 기체상으로 반응시킴으로써 포스겐을 제조하기 위한 포스겐 발생기의 작동 방법이며, 상기 방법에서, 미리 규정가능한 작동 기간 후, 포스겐 제조는 가동정지 기간에 걸쳐 포스겐 발생기를 가동정지함으로써 적어도 일시적으로 중단되고, 미리 규정가능한 휴지기간 후, 포스겐 제조는 시동 기간에 걸쳐 포스겐 발생기를 시동함으로써 재개되며, 여기서 상기 방법은 포스겐 발생기를 시동하기 전에 일산화탄소를 첨가함으로써 활성탄 촉매에서 염소를 제거하여, 시동 기간 동안, 반응 챔버의 바로 하류의 기체 스트림에서의 염소의 최대 농도가 1000 ppmv를 초과하지 않는 것을 특징으로 하는 방법에 관한 것이다. 본 발명은 또한 폴리카르보네이트 및 이소시아네이트의 제조에서의 이와 같이 수득된 포스겐의 용도에 관한 것이다. The present invention is a method of operating a phosgene generator for the production of phosgene by reacting carbon monoxide and chlorine in a gas phase over an activated carbon catalyst arranged in a reaction chamber, wherein, after a predeterminable operating period, the phosgene production is carried out during a shutdown period. is stopped at least temporarily by shutting down the phosgene generator over and after a predeterminable rest period, phosgene production is resumed by starting the phosgene generator over the start-up period, wherein the method comprises activated carbon by adding carbon monoxide prior to starting the phosgene generator. and removal of chlorine from the catalyst such that, during the start-up period, the maximum concentration of chlorine in the gas stream immediately downstream of the reaction chamber does not exceed 1000 ppmv. The invention also relates to the use of phosgene thus obtained in the production of polycarbonates and isocyanates.

Process for the preparation of diaryl carbonate

Es wird ein Verfahren zur Herstellung von Diarylcarbonat und Verarbeitung mindestens eines Teils der dabei anfallenden Alkalichlorid-haltigen Lösung in einer nachgeschalteten Alkalichlorid-Elektrolyse beschrieben. The invention relates to a process for the preparation of diaryl carbonate and to the processing of at least part of the resulting alkali metal chloride-containing solution in a subsequent alkali metal chloride electrolysis.

Process for the preparation of diaryl carbonate

Die Erfindung betrifft ein Verfahren zur Herstellung von Diarylcarbonat, kombiniert mit der Elektrolyse des erhaltenen Alkalichlorid-haltigen Prozessabwassers. Das erfindungsgemäße Verfahren ermöglicht unter anderem eine verbesserte Verwertung der aus der Herstellung des Diarylcarbonats erhaltenen Alkalichlorid-haltigen Lösung in der Elektrolyse. The invention relates to a process for the preparation of diaryl carbonate, combined with the electrolysis of the obtained alkali metal chloride-containing process wastewater. Among other things, the process according to the invention makes possible an improved utilization of the alkali metal chloride-containing solution obtained in the production of the diaryl carbonate in electrolysis.

Method of producing dialkyl dicarbonates using tertiary amines as catalysts

FIELD: chemistry. SUBSTANCE: invention relates to a method of producing dimethyldicarbonate by reacting a methyl ester of chloroformic acid with at least one hydroxide of an alkali metal selected from a group of sodium hydroxide and potassium hydroxide, in the presence of at least one water-immiscible organic solvent selected from cyclohexane, toluene, xylene, methylene chloride and diethyl ether, and in the presence of a catalyst, wherein the catalyst used is at least one tertiary amine of formula (I): NR 1 R 2 R 3 (I), in which R 1 denotes methyl, R 2 denotes unbranched alkyl with 18 carbon atoms and R 3 denotes -[CH 2 -CH(CH 3 )-O] n -[CH 2 -CH(CH 3 )]-OH, wherein n denotes a number varying from 8 to 11, and amount of used tertiary amine of formula (I) ranges from 0.001 to 0.5 mol. %. in terms of an ester of chloroformic acid. EFFECT: present invention enables to obtain an end product with high output. 6 cl РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (51) МПК C07C 68/02 C07C 68/06 C07C 67/02 C07C 69/96 (11) (13) 2 722 826 C1 (2006.01) (2006.01) (2006.01) (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ОПИСАНИЕ ИЗОБРЕТЕНИЯ К ПАТЕНТУ (52) СПК C07C 68/02 (2019.08); C07C 68/06 (2019.08); C07C 67/02 (2019.08); C07C 69/96 (2019.08) (21)(22) Заявка: 2019109429, 02.09.2016 (24) Дата начала отсчета срока действия патента: (73) Патентообладатель(и): ЛЕНКСЕСС ДОЙЧЛАНД ГМБХ (DE) Дата регистрации: 04.06.2020 (45) Опубликовано: 04.06.2020 Бюл. № 16 (85) Дата начала рассмотрения заявки PCT на национальной фазе: 02.04.2019 (86) Заявка PCT: EP 2016/070701 (02.09.2016) 2 7 2 2 8 2 6 (56) Список документов, цитированных в отчете о поиске: WO 2005110964 A1, 24.11.2005. US 3240796 A1, 15.03.1966. US 3326958 A1, 20.06.1967. US 5523481 A1, 04.06.1996. RU 2490251 C9, 27.01.2014. SU 1267746 A1, 27.02.2000. RU 2358967 C2, 20.06.2009. Приоритет(ы): (22) Дата подачи заявки: 02.09.2016 R U 02.09.2016 (72) Автор(ы): ВОГЛЬ, Эрасмус (DE), ХОФМАНН, Кристоф (DE) 2 7 2 2 8 2 6 R U WO 2018/ ...

Three and four atom bridged dicarbonate compounds as internal donors in catalysts for polypropylene manufacture

可用于聚合烯烃的不溶于烃的固体催化剂组分，所述催化剂组分含有镁、钛、和卤素，并进一步含有具有以下结构的内部电子给体：[R 1 -O-C(O)-O-] x R 2 其中R 1 在各出现处独立地为含有1~20个碳原子的脂族或芳族烃，或取代的烃基；x为2-4；以及R 2 为含有1~20个碳原子的脂族或芳族烃，或取代的烃基，条件是在连接第一R 1 -O-C(O)-O-基团和第二R 1 -O-C(O)-O-基团的最短链中有3~4个原子。

Three and four atom bridged dicarbonate compounds as internal donors in catalysts for polypropylene manufacture

可用于聚合烯烃的不溶于烃的固体催化剂组分，所述催化剂组分含有镁、钛、和卤素，并进一步含有具有以下结构的内部电子给体：[R 1 -O-C(O)-O-] x R 2 其中R 1 在各出现处独立地为含有1~20个碳原子的脂族或芳族烃，或取代的烃基；x为2-4；以及R 2 为含有1~20个碳原子的脂族或芳族烃，或取代的烃基，条件是在连接第一R 1 -O-C(O)-O-基团和第二R 1 -O-C(O)-O-基团的最短链中有3~4个原子。

Three and four atom bridged dicarbonate compounds as internal donors in catalysts for polypropylene manufacture

본 발명은 마그네슘, 티타늄 및 할로겐을 함유하고 구조 (식 중, R 1 은 각 경우에 독립적으로 지방족 또는 방향족 탄화수소 또는 1 내지 20개의 탄소 원자를 함유하는 치환된 탄화수소 기이고; x는 2 내지 4이고; R 2 는 지방족 또는 방향족 탄화수소 또는 1 내지 20개의 탄소 원자를 함유하는 치환된 탄화수소 기이되, 단 제1 R 1 -O-C(O)-O- 기 및 제2 R 1 -O-C(O)-O- 기를 연결하는 최단 쇄에 3 내지 4개의 원자가 존재함)를 갖는 내부 전자 공여체를 추가로 함유하는, 올레핀 중합에 유용한 고체의 탄화수소-불용성 촉매 성분에 관한 것이다. The present invention relates to a composition containing magnesium, titanium and a halogen, Wherein R 1 is independently in each occurrence an aliphatic or aromatic hydrocarbon or a substituted hydrocarbon group containing from 1 to 20 carbon atoms, x is from 2 to 4, R 2 is an aliphatic or aromatic hydrocarbon, or from 1 to 20 substituted hydrocarbons containing carbon atoms are marvelous, provided that the 1 R 1 -OC (O) -O- group and a 2 R 1 -OC (O) 3 to 4 atoms in the shortest chain linking -O- groups Insoluble &lt; / RTI &gt; catalytic component of a solid useful for olefin polymerization, further containing an internal electron donor having an &lt; RTI ID = 0.0 &gt;

Modulators of ATP-binding cassette transporters

The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.

Method for synthesizing allyl chloroformate by phosgene method

本发明公开了一种光气法合成氯甲酸烯丙酯的方法，包括如下步骤：步骤一、底投Ag氯甲酸烯丙酯于反应容器中，并控制反应容器中的物料温度在‑2℃～2℃之间；步骤二、通过流量计向反应容器预先通入Bg光气；步骤三、用恒压滴液漏斗滴加烯丙醇至反应容器，控制反应在‑2℃～2℃；同时通入光气并且调节单位时间内；步骤四、烯丙醇滴加完毕，停止通光，得到合格的氯甲酸烯丙酯产品。本发明有效防止了副反应的生成，并且在最后升温到15‑20℃保温，使得烯丙醇反应更加完全，从而有效降低了产物中烯丙醇的含量，大大提高了产品的纯度，降低了储存时出现涨桶和产品浓度下降的可能性。

Method of preparing ester-substituted diaryl carbonates

The present invention relates to an interfacial method of preparing ester-substituted diaryl carbonates. The method includes the steps of: forming a reaction mixture comprising phosgene, an ester-substituted phenol, an organic solvent, and a catalyst selected from the group consisting of a tertiary amine catalyst and a phase transfer catalyst, said reaction mixture having an organic phase and an aqueous phase, wherein said aqueous phase has a brine strength; allowing the reaction mixture to react wherein during the reaction, (i) the aqueous phase has a pH, and the pH is adjusted, if necessary, by the addition of an alkali metal hydroxide solution in amounts such that the pH is greater than or equal to 9.0 during at least some portion of the reaction, and (ii) the brine strength of the aqueous phase is adjusted, if necessary, by varying the concentration of the alkali metal hydroxide solution being added to maintain the pH such that the brine strength is between 15% and a saturated brine solution during at least some portion of the reaction: thereby forming an ester-substituted diaryl carbonate, wherein the reaction mixture is formed with less than 15% water of formulation, and wherein the brine strength is maintained at or above 15% and the pH is maintained at or above 9 for a sufficient portion of the process that the ester-substituted diaryl carbonate is formed with a conversion of at least 90% and a selectivity of at least 98%.

Salicylic acid ester derivative and its production

The present invention provides a salicylic acid ester derivative having an impurity content lower than a specific level and expressed by the following formula (1) (in the formula, R 1 is methyl group or ethyl group, R 2 , which may be substituted optionally, is an alkyl group having a carbon number of from 1 to 30, alkoxy group having a carbon number of from 1 to 30, aryl group having a carbon number of from 6 to 30, aryloxy group having a carbon number of from 6 to 30, aralkyl group having a carbon number of from 6 to 30 or aralkyloxy group having a carbon number of from 6 to 30). The salicylic acid ester derivative is effective as a terminal blocking agent or a polymerization. promoting agent for a polycarbonate, and gives a polycarbonate having good color tone and suitable for optical material use.

Interfacial method of preparing ester-substituted diaryl carbonates

High yields of ester-substituted diary carbonates such as bis-methyl salicyl carbonate were obtained by the condensation of methyl salicylate with phosgene in the presence of a phase transfer catalyst (PTC) in an interfacial reaction system in which the pH of the aqueous phase was greater than 9.3. Using the method of the present invention conversions of greater than 99% were obtained whereas under standard conditions using triethylamine as the catalyst conversions were limited to 70-75% of the methyl salicylate starting material even with a 20 mole % excess of added phosgene. The optimized conditions of the of the present invention use only a slight excess of phosgene and represent an attractive route for the manufacture of bis methyl salicyl carbonate and ester-substituted diaryl carbonates generally.