26-09-2013 дата публикации
Номер: US20130252922A1
The present invention relates to substituted phenoxypyridine compounds of general formula (I) in which R1, R2 and R3 are as defined in the claims, to methods of preparing said compounds, to intermediates for the preparation of said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients. 2. The compound according to claim 1 , wherein:{'sub': 1', '6', '2', '6', '3', '6, 'claim-text': a halogen atom, or a', {'sub': 1', '6', '1', '6', '2', '1', '6', '1', '6', '1', '6', '1', '6', '1', '6', '1', '6', '1', '6', '1', '6', '3', '10', '1', '6', '1', '6', '1', '6', '1', '6', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '1', '6', '2', '1', '6', '2', '2', '2', '2', '2', '2, 'CN, C-C-alkyl-, halo-C-C-alkyl-, HN—C-C-alkyl-, R(R′)N—C-C-alkyl-, HO—C-C-alkyl, C-C-alkyl substituted with two OH groups, C-C-alkoxy-C-C-alkyl-, halo-C-C-alkoxy-C-C-alkyl-, C-C-cycloalkyl-C-C-alkyl-, 3- to 10-membered 3- to 7-membered heterocycloalkyl-C-C-alkyl-, aryl-C-C-alkyl-, heteroaryl-C-C-alkyl-, —C(═O)R, —C(═O)NH, —C(═O)N(H)R, —C(═O)N(R)R′, —C(═O)OH, —C(═O)OR, —NH, —N(H)R, —N(R)R′, —N(H)C(═O)H, —N(H)C(═O)R, —N(R)C(═O)R′, —N(H)C(═O)NH, —N(H)C(═O)N(H)R, —N(H)C(═O)N(R)R′, —N(R)C(═O)NH, —N(R)C(═O)N(H)R, —N(R)C(═O)N(R)R′, —N(H)C(═O)OR, —N(R)C(═O)OR, —NO, —N(H)S(═O)R, —N(R)S(═O)R′, —N(H)S(═O)NH, —N(H)S(═O)N(H)R, —N(H)S(═O)N(R)R′, —N(R)S(═O)NH, —N(R)S(═O)N(H)R′, —N(R)S(═O)N(R′)R″, —N(H)S(═O)R, —N(H)S(═O)—C3-C6-cycloalkyl, —N(R)S(═O)R′, —N(H)S(═O)NH, —N(H)S(═O)N(H)R, —N(H)S(═O)N(R)R′, —N(R)S(═O)NH, —N(R)S(═O)N(H)R, —N(R)S(═O)N(R′)R″, —N═S(═O)(R)R′, —OH, C-C-alkoxy-, —OC(═O)H, —OC(═O)R, —OC(═O)NH, —OC(═O)N(H)R, —OC(═O)N(R)R′, —OC(═O)OR, —SH, C-C-alkyl-S—, —SC(═O)NH, —SC(═O)N(H)R, ...
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