25-07-2013 дата публикации
Номер: US20130190315A1
Принадлежит:
Provided are substituted benzaldehydes and derivatives thereof that act as allosteric modulators of hemoglobin, methods and intermediates for their preparation, pharmaceutical compositions comprising the modulators, and methods for their use in treating disorders mediate by hemoglobin and disorders that would benefit from increased tissue oxygenation. 2. A compound according to claim 1 , wherein:{'sub': '2', 'Y is O or CH;'}{'sub': '2', 'X is O or CH;'}Q is selected from the group consisting of:{'sup': 'a', 'claim-text': {'sup': 2', '3', '4', '5', 'b', 'd', 'd', 'd', 'd', 'e', 'd', 'd', 'd', 'd', 'd', 'd', 'd', 'd', 'd', 'd', 'e', 'd', 'e', 'd', 'd', 'd', 'e', 'e', 'd', 'e', 'd', 'd, 'sub': 2', 'z', '2', 'z', '2', '2', '2', '2', '2', '2', '3, 'R, R, R, and R, are independently selected from the group consisting of hydrogen, halo, R, OR, O(CH)OR, O(CH)NRR, OC(O)R, SR, CN, NO, COR, CONRR, C(O)R, OC(O)NRR, NRR, NRC(O)R, NRC(O)R, NRC(O)NRR, S(O)R, S(O)R, NRS(O)R, S(O)NRR, and Nwhere z is 1, 2, or 3; and'}, 'i) imidazopyridinyl, methylimidazopyridinyl, indazolyl, pyrrolopyridinyl, pyrrolopyrazinyl, pyrazolopyridinyl, pyrazolopyrazinyl, and quinolinyl, each of which is optionally substituted with one to three R; wherein'}{'sup': 'a', 'claim-text': [{'sup': 2', '3', '4', 'b', 'd', 'd', 'd', 'd', 'e', 'd', 'd', 'd', 'd', 'd', 'd', 'd', 'd', 'd', 'd', 'e', 'd', 'e', 'd', 'd', 'd', 'e', 'e', 'd', 'e', 'd', 'd, 'sub': 2', 'z', '2', 'z', '2', '2', '2', '2', '2', '2', '3, 'R, R, and Rare independently selected from the group consisting of hydrogen, halo, R, OR, O(CH)OR, O(CH)NRR, OC(O)R, SR, CN, NO, COR, CONRR, C(O)R, OC(O)NRR, NRR, NRC(O)R, NRC(O)R, NRC(O)NRR, S(O)R, S(O)R, NRS(O)R, S(O)NRR, and Nwhere z is 1, 2, or 3; and'}, {'sup': 5', 'd, 'Ris selected from the group consisting of halo and OR;'}], 'ii) pyridinyl and piperidinyl, each of which is optionally substituted with one to three R; wherein'}{'sup': 6', '7, 'Rand Rtogether form oxo or an aldehyde protecting group;'}{' ...
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