05-09-2013 дата публикации
Номер: US20130231333A1
Described herein are compounds that are estrogen receptor modulators. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well methods of using such estrogen receptor modulators, alone and in combination with other compounds, for treating diseases or conditions that are mediated or dependent upon estrogen receptors. 2. The compound of claim 1 , or a pharmaceutically acceptable salt claim 1 , or N-oxide thereof claim 1 , wherein:ring A is 5- or 6-membered monocyclic heteroaryl or 8-, 9- or 10-membered bicyclic heterocycle;ring B is phenyl, naphthyl, 5- or 6-membered monocyclic heteroaryl or 8-, 9- or 10-membered bicyclic heterocycle;ring C is phenyl, or 5- or 6-membered monocyclic heteroaryl;{'sup': 3', '8', '8′', '9', '9', '10', '10', '10', '9', '10', '10', '9', '9, 'sub': 2', '2', '2', '2', '2', '2', '1', '4', '2', '4', '2', '4', '1', '4', '1', '4', '1', '4', '1', '4, 'each Ris independently selected from H, halogen, —NRR, —CN, —OH, —OR, —SR, —S(═O)R, —S(═O)R, —NHS(═O)R, —S(═O)N(R), —C(═O)R, —OC(═O)R, —COR, —C(═O)N(R), C-Calkyl, C-Calkenyl, C-Calkynyl, C-Cfluoroalkyl, C-Cheteroalkyl, C-Cfluoroalkoxy, and C-Calkoxy;'}{'sup': 4', '8', '8′', '9', '9', '10', '10', '10', '9', '10', '10', '9', '10', '9', '9', '9', '9', '9', '10', '9', '10, 'sub': 2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '1', '6', '2', '6', '2', '6', '1', '6', '1', '6', '1', '6', '1', '6, 'each Ris independently selected from H, halogen, —NO, —NRR, —CN, —OH, —OR, —SR, —S(═O)R, —S(═O)R, —NHS(═O)R, —S(═O)N(R), —C(═O)R, —OC(═O)R, —COR, —OCOR, —C(═O)N(R), —OC(═O)N(R), —NRC(═O)N(R), —NRC(═O)R, —NRC(═O)OR, substituted or unsubstituted C-Calkyl, substituted or unsubstituted C-Calkenyl, substituted or unsubstituted C-Calkynyl, substituted or unsubstituted C-Cfluoroalkyl, substituted or unsubstituted C-Cheteroalkyl, substituted or unsubstituted C-Cfluoroalkoxy, substituted or unsubstituted C-Calkoxy, substituted or unsubstituted phenyl and ...
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