04-02-2016 дата публикации
Номер: US20160031820A1
Принадлежит:
This invention provides compounds of formula (I): 3. The compound of claim 2 , wherein:{'sub': 1', '2, 'Vis —C(O)—, —C(O)—NH—, or —S(O)—;'}{'sub': '2', 'Vis —NH— or —O—;'}{'sup': '1', 'Ris chloro, fluoro, cyano, hydroxy, methoxy, ethoxy, trifluoromethoxy, trifluoromethyl, methyl, or ethyl;'}{'sup': '2', 'each occurrence of Ris independently fluoro, methyl, or trifluoromethyl;'}m is 0-1; andn is 0-2.5. The compound of claim 2 , wherein:{'sup': 3', '5', '5', '5a', '5d', '5d', '5d, 'sub': 3', '3', '3, 'Rwhen substituted is substituted with 1-4 independent occurrences of —R, wherein Ris —R, —R, -L-R, or —V-L-R;'}{'sup': 5a', '5b', '5b', '5c', '5c', '5c', '5b', '5b', '5b', '5b', '5b', '5e', '5b', '5e', '5c', '5e', '5b', '5e', '5b', '5e', '5b', '5dd', '5b', '5b', '5c', '5c', '5c', '5b', '5b', '5b', '5b', '5b', '5e', '5b', '5e', '5c', '5e', '5b', '5e', '5b', '5e', '5b, 'sub': 1-3', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '1-4', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2, 'each occurrence of Ris independently halogen, Caliphatic, —CN, —NO, —N(R), —OR, —SR, —S(O)R, —S(O)R—C(O)R, —C(O)OR, —C(O)N(R), —S(O)N(R), —OC(O)N(R), —N(R)C(O)R, —N(R)SOR, —N(R)C(O)OR, —N(R)C(O)N(R), or —N(R)SON(R), or a Caliphatic substituted with R, halogen, —CN, —NO, —N(R), —OR, —SR, —S(O)R, —S(O)R—C(O)R, —C(O)OR, —C(O)N(R), —S(O)N(R), —OC(O)N(R), —N(R)C(O)R, —N(R)SOR, —N(R)C(O)OR, —N(R)C(O)N(R), or —N(R)SON(R);'}{'sup': 5b', '5b, 'sub': '1-6', 'each occurrence of Ris independently hydrogen or an optionally substituted group selected from Caliphatic, 3-10-membered cycloaliphatic, 4-10-membered heterocyclyl having 1-4 heteroatoms independently selected from nitrogen, oxygen, and sulfur, 6-10-membered aryl, or 5-10-membered heteroaryl having 1-4 heteroatoms independently selected from nitrogen, oxygen, and sulfur; or two occurrences of Ron the same nitrogen atom can be taken together with the nitrogen atom to which they are bound to form an optionally substituted 4-7-membered ...
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