СПОСОБ ПОЛУЧЕНИЯ МОНОНИТРАТА СЕРТАКОНАЗОЛА И МОНОГИДРАТ МОНОНИТРАТА СЕРТАКОНАЗОЛА

... 1. Способ получения мононитрата сертаконазола (I), в котором сначала осуществляют химическую реакцию 1-(2,4-дихлорфенил)-2-(1H-имидазол-1-ил)этанола (II) с 3-бромметил-7-хлорбензо[b]тиофеном (III) в присутствии гидросульфата тетрабутиламмония (IV, Z=HSO4) и гидроксида натрия в толуоле при 30-45°С, после чего к смеси добавляют воду, ее охлаждают до температуры 0-15°С и затем твердое вещество отделяют фильтрованием и промывают водой и толуолом; полученное таким образом свободное основание сертаконазола смешивают с абсолютным этанолом и нагревают в колбе с обратным холодильником до полного растворения; смесь нагревают до 60-80°С и к ней добавляют воду, затем смесь охлаждают до 5-15°С; полученное твердое вещество отделяют фильтрованием и промывают раствором этанола в воде; полученное чистое свободное основание сертаконазола растворяют в абсолютном этаноле при 70-80°С, смесь охлаждают до 65-75°С, добавляют раствор, содержащий 60%-ную азотную кислоту в воде, и выдерживают при этой температуре ...

IMIDAZOLYLPHENYL AMIDINES

Compounds

Compounds of general formula (I): wherein R1, R2, R3, R4, R5a, R5b X1, X2, Z and Y are as defined herein are positive modulators of the calcium-activated chloride channel (CaCC), TMEM16A. The compounds are useful for treating diseases and conditions affected by modulation of TMEM16A, particularly respiratory diseases and conditions.

BENZIMIDAZOLE DERIVATIVES

Method of preparation of new diaza-cyclo-alkanes.

Method of preparation of new heterocyclic compounds, inter alia 1 (5-nitro-thiazolyl- (2) - 2-oxo-tétrahydro-imidazol.

New 2-oxo-1,3-diaza-cyclo-alkanes and process for their preparation.

BIOZIDE MITTEL

PROCEDURE FOR THE PRODUCTION OF CYANAETHYLIERTER BENZODIAZEPINE

MALONIC ACID NITRILE CONNECTION AND THEIR USE

IMIDAZOLYL-PHENYL AMIDINES

2-PHENOXYMETHYL-IMIDAZOLINE DERIVATIVES

3-CARBONYL-1-AMINOALKYL-1H-INDOLES AND THEIR USE AS ANALGESICS

IMIDAZOLYLPHENYL AMIDINES, PROCESSES FOR THEIR PREPARATION AND THEIR PHARMACEUTICAL USE, AND INTERMEDIATES OF PREPARATION

ABSTRACT OF THE DISCLOSURE The object of the present invention is new pharma-cologically active substituted imidazolylphenyl amidines of the following formula (I) in which R, R1 and R3, which may be the same of different represent a hydrogen atom or a lower alkyl group, and R2 represents a linear or branched alkyl, alkenyl or alkynyl group, a cyano group, a hydroxyl group, a substituted or unsubstituted cycloalkyl or cycloaliphatic alkyl group, a bicyclic group, an aralkyl or aryl group (optionally substituted by a halogen atom, a methyl, methoxy or methylenedioxy group) or a substituted or unsubstituted heterocycloalkyl or heterocyclic group which may also contain a further hetero atom; end non-toxic acid addition salts thereof. Processes for the preparation of the compounds of formula I and their intermediates as well as pharmaceutical compositions containing them are also objects of this invention. The new compounds are H2 receptor blocking agents which inhibit gastric acid secretion and are useful antiulcer agents.

COMPOUNDS

Compounds of general formula (I): wherein R1, R2, R3, R4, R5a, R5b X1, X2, Z and Y are as defined herein are positive modulators of the calcium-activated chloride channel (CaCC), TMEM16A. The compounds are useful for treating diseases and conditions affected by modulation of TMEM16A, particularly respiratory diseases and conditions.

IMIDAZOLE HYDRAZONE DERIVATIVES

Verfahren zur Herstellung neuer Imidazole

Verfahren zur Herstellung neuer heterocyclischer Verbindungen

Verfahren zur Herstellung neuer Diazacycloalkanverbindungen

Verfahren zur Herstellung neuer Diazacycloalkanverbindungen

Verfahren zur Herstellung neuer Imidazole

Verfahren zur Herstellung neuer Imidazole

BENZIMIDAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND ANTI-ULCER AGENTS CONTAINING THE SAME.

IMIDAZOLYL PROPIONITRILE ONE, PROCEDURE FOR THE PRODUCTION OF THESE CONNECTIONS AS WELL AS THESE CONTAINING BIOCIDES MEANS AND MEANS WITH GROWTH-ADJUSTING EFFECT.

IN THE MEDICINE USABLE ONE N-IMIDAZOLYLDERIVATE ONE OF BICYCLI CONNECTIONS.

SUBSTITUTED [1.2, 4] TRIAZOLE AND IMIDAZOLE COMPOUNDS AS FUNGICIDES

Halogen-free epoxy resin composition, prepreg containing same, laminated board and printed circuit board

METHOD FOR THE PRODUCTION OF CHIRAL IMIDAZOLIDIN-2-ONES

The invention relates to a method for producing chiral imidazolidin-2-ones of general formula I, in which R1 represents C1-C8-alkyl, cyclohexyl-, phenyl-, a phenyl radical substituted with C1-C6-alkyl-, halo-, nitro-, C1-C6-alkoxy-, C1-C6-alkylmercapto-, or CF3-, naphthyl-, or a naphthyl radical substituted with C1-C6-alkyl-, halo-, nitro-, C1-C6-alkoxy-, or CF3-, R2 represents C1-C8-alkyl-, C1-C8-alkenyl, cyclohexyl-, phenyl-, or a phenyl-C1-C6-alkyl radical which can be substituted with a nitro-, C1-C6-alkoxy-, methylendioxi-, or CF3 radical, and R3 represents C1-C12 alkyl-, C1-C8-alkenyl-, cyclohexyl-, phenyl-, or a phenyl radical substituted with C1-C6-alkyl-, halo-, nitro-, C1-C6-alkoxy, methylendioxi-, dialkylamine-, or CF3-, by reacting a compound of general formula II or the salt thereof, R1, R2, and R3 having the meaning indicated above, with urea in the presence of a non-volatile ammonium salt, said reaction being carried out in the presence of an aprotic polar organic solvent ...

КОМПОЗИЦИИ И СПОСОБЫ ЛЕЧЕНИЯ ИНФЕКЦИОННЫХ ЗАБОЛЕВАНИЙ РОТОВОЙ ПОЛОСТИ

Neue Tetrahydro-imidazole und Verfahren zu ihrer Herstellung

N-Imidazolyl derivatives for treating nephropathies

Compounds of formula: <IMAGE> where <IMAGE> wherein Y completes a single bond or is oxygen or a -CH2-group and --- is a single or a double bond or (b> <IMAGE> and --- is a double bond; one of R1, R2, R3 and R4 is -CH2OH, C2-C4 acyl, <IMAGE> in which each each of R7, R8 and R9 is hydrogen or C1-C4 alkyl and the others are chosen from hydrogen, hydroxy, halogen, C1-C4 alkyl, C1C4 alkoxy and -COOR7 wherein R7 is as above, and one of R5 and R6 is hydrogen and the other is hydrogen, C1-C6 alkyl or phenyl; or a pharmaceutically acceptable salt thereof are used to treat nephropathies.

Compounds

5-(INDOL-3-YLMETHYLENE)-1,3-DIMETHYL-2-METHYLIMINO-4-IMIDAZOLIDINONE

AETHEROXIDDERIVATE OF ZYKLOPROPYLPHENOLEN.

PROCEDURE FOR THE PRODUCTION OF PHENYLAETHYLTRIAZOLEN.

Procedure for the production of new 2-Oxo-1,3-diazacycloalkanverbindungen

Procedure for the production of new 2-Oxo-1,3-diazacycloalkanverbindungen

METHOD FOR THE PRODUCTION OF CHIRAL IMIDAZOLIDIN-2-ONES

Method for the production of chiral imidazolidin-2-ones

PROCESS FOR THE PREPARATION OF NOVEL ETHER-OXYDES DERIVED FROM CYCLOPROPYLPHENOLS

ABSTRACT OF THE DISCLOSURE The present invention relates to a process for the preparation of novel imidazolines of general formula (I)

BENZODIAZEPINE ANALOGS

TITLE OF THE INVENTION BENZODIAZEPINE ANALOGS ABSTRACT OF THE DISCLOSURE Benzodiazepine analogs of the formula: I are disclosed which are antagonists of cholecysto-kinin (CCK).

IMIDAZOLE-HYDRAZONES HAS ACTIVITY ANTIBACTERIENNE AND METHOD OF PREPARATION

Method of preparation of new heterocyclic compounds, inter alia 1 [5-nitro-thiazolyl- (2)]- 2-oxo-tétrahydro-imidazol

New imidazols and process for their preparation

Imidazole hydrazone derivatives

Compounds corresponding to the following general formula: wherein Ar and Ar1, which may be the same or different, each represents an aromatic radical which may be substituted one or more times by halogen and/or nitro and/or lower alkyl and/or trihalomethyl and/or cyano and/or lower alkoxy and/or di-lower alkyl-amino, the alkyl groups optionally completing a ring optionally incorporating a further heteroatom, and/or lower alkyl sulphonyl; Alk1 and Alk2, which may be the same or different, each represents an alkylene group containing from one to eight carbon atoms which may be substituted one or more times by aryl and/or cycloalkyl and/or lower alkyl and if two such alkyl groups are present, they may complete a ring optionally containing a heteroatom and in which imidazole ring may be further substituted; and m represents 0 or 1; provided that not both Ar and Ar1 represent phenyl; and acid addition salts thereof. Such compounds are prepared by reaction of a compound corresponding ...

PROCESS FOR THE PREPARATION OF PHENYLETHYL TRIAZOLES

5-nitrothiazolyl-oxodiazacycloalkanes and process for their manufacture

The invention comprises compounds of the formula in which R1 represents a hydrogen atom or a C1- 7 alkyl group, Z represents a C3- 7 alkylene group which separates the two nitrogen atoms by 3 to 5 carbon atoms and which may be substituted by one or more C1- 7 alkyl groups, and R represents a hydrogen atom, a C2- 7 alkenyl group or a C1- 7 alkyl group which is unsubstituted or substituted by a hydroxy group or by a free or mono- or di-C1- 7 alkyl-substituted amino group or by an alkyleneimino or an oxa-, aza- or thiaalkyleneimino groups; acid addition salts thereof; and their preparation by (a) intramolecularly condensing a compound of the formula in which Z represents a C3- 7 alkylene group which separates the chlorine atom from its nearest nitrogen atom by 3 to 5 carbon atoms and which may be substituted by one or more C1- 7 alkyl groups, by heating in the presence of a basic condensation agent, and, if desired, reacting the compound obtained with ...

BENZODIAZEPIN DERIVATIVES AND THESE CONTAINING DRUGS.

VERFAHREN ZUR HERSTELLUNG CYANAETHYLIERTER BENZODIAZEPINE

PROCEDURE FOR THE PRODUCTION OF IMIDAZOLVERBINDUNGEN AND SALTING AND THEIR PSEUDOPOLYMORPHEN

Talarazole metabolites

Metal complexes of poly(carboxyl)amine-containing ligands having an affinity for carbonic anhydrase IX

The present invention is directed to CA I X inhibitors that conform to Formula 1 where the substituents X, A, B, D, E, E' and G are as defined above. Also described are Pt, ...

Benzimidazole derivatives for antiulcercous purposes

SPRAYER AND DIAPHRAGM PUMP THEREFOR

A garden sprayer for dispensing pressurized liquids has a pressure vessel mounted within a liquid reservoir container. The pressure vessel carries a diaphragm pump which is detachable as a complete unit and which extends from the container for connection to a pivoted actuating lever that is fulcrumed on the container. The diaphragm, which is directly driven by the pivoted lever, is guided in position and orientation by a guide piston fixed to the diaphragm and slidably guided within the pumping chamber. A pair of input and output check valves, mounted at the end of the pump, permit liquid from the container to be drawn into the pumping chamber and to be forced from the pumping chamber into the pressure vessel. A manually controlled valve on a spray nozzle, which is connected to the pressure vessel, controls pressurized discharge of liquid.

N-IMIDAZOLYL DERIVATIVES OF BICYCLIC COMPOUNDS USEFUL IN MEDICINE

A B S T R A C T N-Imidazolyl Derivatives of Bicyclic Compounds useful in medicine. The invention relates to the use of a compound of formula (I) (I) wherein (a) is wherein Y completes a single bond or is oxygen or a -CH2- group and the symbol represents a single or a double bond or (b) is and the symbol represents a double bond; one of R1, R2, R3 and R4 is -CH2OH, C2-C4 acyl, , -COOR7, -CH2-COOR7, , -CH-?-COOR? or

COMPOSITIONS AND METHODS FOR THE TREATMENT OF ORAL INFECTIOUS DISEASES

The invention relates to the compounds or its pharmaceutical acceptable polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula I, formula II, formula III, formula IV, formula V, formula VI, formula VII, formula VIII, formula IX, formula X, formula XI and formula XII and, the methods for the treatment of oral infectious diseases may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, lozenge, spray, intravenous, oral solution, buccal mucosal layer tablet, parenteral administration, syrup, or injection. Such compositions may be used to treatment of oral infectious diseases.

TALARAZOLE METABOLITES

Novel metabolites of talarazole of formula (I) have been isolated and cha racterized, wherein R = H, OH, OSO3H or O-gly; R1, = H, OH, OSO3H, O-gly or =0; and gly = a glucuronate, or a pharmaceutically acceptable salt thereof. These compounds are targeted for the treatment of various skin-, hair- and n ail-associated disorders.

Imidazole derivatives for treatment of allergic and hyperproliferative disorders

The preferred embodiments are directed to small molecule inhibitors of the IgE response to allergens, which are useful in the treatment of allergy and/or asthma or any diseases where IgE is pathogenic. The preferred embodiments also relate to imidazole molecules that are cellular proliferation inhibitors and thus are useful as anticancer agents. The preferred embodiments further relate to small molecules which suppress cytokines and leukocytes.

Compounds as nuclear transport modulators and uses thereof

The present invention relates compounds of Formula I'-III', as well as their preparation and uses, and further relates pharmaceutical compositions comprising these compounds and their uses as nuclear transport modulators. The present invention also relates to uses of the compounds or pharmaceutical compositions in treating or preventing certain neurological disorders and diseases as well as certain types of cancer in humans.

ИОННЫЕ ЖИДКОСТИ С СИЛОКСАНОВЫМ ФРАГМЕНТОМ В СОСТАВЕ КАТИОНА В КАЧЕСТВЕ ТЕПЛОНОСИТЕЛЕЙ

FIELD: chemistry. SUBSTANCE: invention relates to liquid heat carriers. Disclosed are ionic liquids with siloxane fragment in cation of general formula I, where R=Y=CH 3 , X=(-Si(CH 3 ) 2 ) 2 O, n=1 or 3, or X=(-Si(C 2 H 5 ) 2 ) 2 O, n=1; either R=CH 3 , Y=H, n=1, X=-Si(CH 3 ) 2 OSi(CH 3 )(C 6 H 5 )OSi(CH 3 ) 2 -; either R=C 6 H 5 (CH 3 ) 2 SiOSi(CH 3 ) 2 -, Y=H, X=CH 2 , n=1, as heat carriers. Novel dicationic ionic liquids with one or two siloxane fragments in a cation of general formula I have significantly lower evaporation capacity (volatility) (less than 0.07 mg/h with area of 1 cm 2 in conditions of dynamic vacuum) and low pressure of saturated vapour (<10 -4 mm Hg) in region of high temperatures (230 °C) in comparison to other existing heat carriers (including ionic liquids studied at present moment), which ensures their explosion safety and considerably lower volatility in dynamic vacuum and open space, as well as physical and chemical and thermophysical properties (viscosity, density, volatility, heat capacity and heat conductivity), enabling their use as heat carriers, as well as components of lubricating and sealing fluids. EFFECT: low evaporating capacity and low pressure of saturated vapour. 1 cl, 2 tbl, 5 ex РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 2 600 932 C1 (51) МПК C07F 7/10 (2006.01) C09K 5/04 (2006.01) C09K 5/10 (2006.01) C07D 233/00 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ОПИСАНИЕ (21)(22) Заявка: ИЗОБРЕТЕНИЯ К ПАТЕНТУ 2015151073/04, 30.11.2015 (24) Дата начала отсчета срока действия патента: 30.11.2015 (45) Опубликовано: 27.10.2016 Бюл. № 30 2 6 0 0 9 3 2 R U (54) ИОННЫЕ ЖИДКОСТИ С СИЛОКСАНОВЫМ ФРАГМЕНТОМ В СОСТАВЕ КАТИОНА В КАЧЕСТВЕ ТЕПЛОНОСИТЕЛЕЙ (57) Реферат: Изобретение относится к области жидких теплоносителями (включая изученные к теплоносителей. Предложены ионные жидкости настоящему времени ионные жидкости), что с силоксановым фрагментом в составе катиона обеспечивает их взрывобезопасность и общей формулы I ...

Sprayer and diaphragm pump for it

A garden sprayer (10) for dispensing liquids under pressure has a pressure vessel (50) mounted within a liquid reservoir (12). The pressure vessel (50) carries a diaphragm pump (124) which is detachable as a unit and which is pivotally connected to an actuating lever (40) that is pivotally connected to the reservoir (12). The diaphragm (129) of the pump is directly driven by the pivoted lever (40) and, is guided in position and orientation by a guide piston (152) fixed to the diaphragm (129) and slidably guided within a cylindrical portion (66) of a pumping chamber (70). A pair of input and output non-return valves (100, 102) mounted at the end of the pump, permit liquid from the reservoir (12) to be drawn into the pumping chamber (70) and then to be forced from the pumping chamber (70) into the pressure vessel (50). A manually controlled valve on a spray nozzle, which is connected to the pressure vessel (50) controls pressurized discharge of liquid. ...

BENZIMIDAZOLE DERIVATIVES

Benzimidazole derivatives of the formula (where R1 is hydrogen, C1-8 alkyl, cycloalkyl, phenyl or aralkyl, R2 is hydrogen or C1-8 alkyl, or R1 and R2 together form a ring with the adjacent nitrogen atom, and R3 and R4 are hydrogen, halogen, trifluoromethyl, alkyl, alkoxy, alkoxycarbonyl or amino) are antiulcer agents.

PROCEDURE FOR THE PRODUCTION OF CHIRALEN IMIDAZOLIDIN-2-ONEN

ISOHEXID NUCLEOSIDES, PROCEDURES FOR YOUR PRODUCTION AND YOUR USE AS DRUGS.

LIPID DERIVATIVES, YOUR PRODUCTION AND USE.

3-CARBONYL-1-AMINOALKYL-1H-INDOLE, USABLE AS ANALGESICS AND YOUR PRODUCTION.

IMIDAZOLYLPHENYLAMIDINE, PROCEDURE FOR THE PRODUCTION, YOUR PHARMACEUTICAL APPLICATION AND INTERMEDIATE PRODUCTS FOR YOUR PRODUCTION.

PROCEDURE FOR the PRODUCTION OF 5-METHYL-4IMIDAZOLCARBONS|UREESTERN.

3-CARBONYL-1-AMINOALKYL-1H-INDOLES AND THEIR USE AS ANALGESICS

ISOHEXIDE-NUCLEOSIDE

Substituted [1,2,4]triazole and imidazole compounds as fungicides

The present invention relates to compounds of the formula (I) wherein the variables are defined in the claims and the specification, to their preparation and their use as fungicides.

Novel compounds

ISOHEXIDE-NUCLEOSIDE

Abstract The invention relates to novel isohexide nucleosides of the general formula I

SALT Of ANION PENTACYLIQUE AND ITS USE AS ELECTROLYTE

IMIDAZOLE-HYDRAZONES A ACTIVITE ANTIBACTERIENNE ET PROCEDE DE PREPARATION

L'INVENTION CONCERNE DES IMIDAZOLE-HYDRAZONES. CES COMPOSES REPONDENT A LA FORMULE QUI SUIT: (CF DESSIN DANS BOPI) DANS LAQUELLE AR ET AR, IDENTIQUES OU DIFFERENTS, REPRESENTENT UN RADICAL AROMATIQUE EVENTUELLEMENT SUBSTITUE ET ALK ET ALK, IDENTIQUES OU DIFFERENTS, REPRESENTENT CHACUN UN GROUPE ALKYLENE DE 1 A 8ATOMES DE CARBONE EVENTUELLEMENT SUBSTITUE, M REPRESENTE 0 OU 1 ET AR ET AR NE PEUVENT PAS TOUS DEUX REPRESENTER DES RADICAUX PHENYLE. CES COMPOSES SONT DES SUBSTANCES ANTIBACTERIENNES.

IMIDAZOL-HYDRAZON-DERIVAT

ПРОИЗВОДНЫЕ МАЛОНОНИТРИЛА И ИХ ПРИМЕНЕНИЕ

FIELD: chemistry. ^ SUBSTANCE: invention relates to novel malononitryl derivatives of formula (I), which can be applied to fight pest insects. In formula (I) R1 represents hydrogen atom; R2 represents hydrogen atom; R represents hydrogen atom; R4 represents C1-C5-alkyl group substituted with at least one halogen atom, C2-C5-alkenyl group; R5 represents hydrogen atom, halogen atom, C1-C5-alkyl group; at least one of X1, X2 and X3 values represents CR6, the other represent nitrogen atoms; R represents hydrogen atom, halogen atom, cyanogroup, nitrogroup, formyl group, C1-C5-alkyl group optionally substituted with at least one halogen atom, C1-C5-alkyltiogroup, substituted with at least one halogen atom, C2-C6-alkylcarbonyl group substituted with at east one halogen atom, C2-C5-alkoxycarbonyl group or group (CH2)mQ, where m = 0, and Q stands for phenyl; and in case when one of R5 and R6 is bonded with two atoms in adjacent positions or two R6 are bonded with two atoms in adjacent positions, they can be bonded to each other in end positions with formation of C2-C6-alkandiyl group, or C4-C6-alkenediyl group. Invention also relates to composition and method used to fight pest-insects. ^ EFFECT: obtaining novel malononitryl derivatives of formula (I), which can be applied to fight pest-insects. ^ 11 cl, 90 ex РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) 2 362 769 (13) (51) МПК C07D C07D C07D C07D C07D C07D ФЕДЕРАЛЬНАЯ СЛУЖБА C07D ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ, C07D ПАТЕНТАМ И ТОВАРНЫМ ЗНАКАМ C07D C07D (12) ОПИСАНИЕ 209/12 209/42 209/30 207/42 207/34 249/08 231/12 231/14 231/16 231/18 C07D C07D A01N A01N A01N A01N A01N A01N A01P (2006.01) (2006.01) (2006.01) (2006.01) (2006.01) (2006.01) (2006.01) (2006.01) (2006.01) (2006.01) C2 231/54 (2006.01) 233/68 (2006.01) 43/36 (2006.01) 43/38 (2006.01) 43/50 (2006.01) 43/56 (2006.01) 43/653 (2006.01) 47/02 (2006.01) 7/04 (2006.01) ИЗОБРЕТЕНИЯ К ПАТЕНТУ (21), (22) Заявка: 2006129638/04, 12.01.2005 (24) Дата начала отсчета срока действия ...

Patent RU2019119103A3

РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (51) МПК A61K 31/00 (2006.01) A61P 31/10 (2006.01) C07D 233/00 (2006.01) C07D 233/58 (2006.01) C07D 233/60 (2006.01) C07D 233/62 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА C07D 233/91 (2006.01) ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ C07D 249/08 (2006.01) C07D 401/06 (2006.01) C07D 403/06 (2006.01) (12) (13) 2019 119 103 A C07D 405/06 (2006.01) C07D 405/14 (2006.01) C07D 409/12 (2006.01) ЗАЯВКА НА ИЗОБРЕТЕНИЕ (21)(22) Заявка: 2019119103, 19.04.2017 (71) Заявитель(и): ЦЕЛЛИКС БИО ПРАЙВЕТ ЛИМИТЕД (IN) Приоритет(ы): (30) Конвенционный приоритет: (43) Дата публикации заявки: 21.12.2020 Бюл. № 36 (72) Автор(ы): КАНДУЛА, Махеш (IT) (86) Заявка PCT: IB 2017/052244 (19.04.2017) (87) Публикация заявки PCT: R U Адрес для переписки: 105215, Москва, а/я 26 Рыбина Н. А. (54) КОМПОЗИЦИИ И СПОСОБЫ ЛЕЧЕНИЯ ИНФЕКЦИОННЫХ ЗАБОЛЕВАНИЙ РОТОВОЙ ПОЛОСТИ (57) Формула изобретения 1. Соединение с формулой I, A 2 0 1 9 1 1 9 1 0 3 A WO 2018/096405 (31.05.2018) 2 0 1 9 1 1 9 1 0 3 (85) Дата начала рассмотрения заявки PCT на национальной фазе: 19.06.2019 R U 28.11.2016 IN 201641040639 Формула I, и его фармацевтически приемлемые гидраты, сольваты, энантиомеры и стереоизомеры; где RH независимо представляет собой Стр.: 1 A 2 0 1 9 1 1 9 1 0 3 R1, R2, R3 независимо представляет собой A R U где при условии, что 2 0 1 9 1 1 9 1 0 3 ; R U 1-гидрокси-2-нафтойную кислоту, 2,2-дихлоруксусную кислоту, 2гидроксиэтансульфоновую кислоту, 2-оксоглутаровую кислоту, 4-ацетамидобензойную кислоту, 4-аминосалициловую кислоту, уксусную кислоту, адипиновую кислоту, аскорбиновую кислоту, аспарагиновую кислоту, бензолсульфоновую кислоту, бензойную кислоту, камфорную кислоту, камфора-10-сульфоновую кислоту, каприновую кислоту (декановую кислоту), капроновую кислоту (гексановую кислоту), угольную кислоту, коричную кислоту, лимонную кислоту, цикламиновую кислоту, додецилсерную кислоту, этан-1,2-дисульфокислоту, этансульфоновую кислоту, муравьиную кислоту, галактаровую кислоту, гентизиновую кислоту, ...

Дикатионные ионные жидкости с полисилоксановым фрагментом в составе катиона в качестве теплоносителей

Изобретение относится к области жидких теплоносителей. Предложены дикатионные ионные жидкости с полисилоксановым фрагментом в составе катиона общей формулы (I), где R 1 и R 2 - метил или фенил, R 3 - CH 2 или (СН 2 ) 3 , n=3-8, в качестве теплоносителей. Технический результат – предложенные новые дикатионные ионные жидкости (ИЖ) с полисилоксановым фрагментом в составе катиона общей формулы (I) являются жидкими при нормальных условиях и имеют более низкое давление насыщенных паров (ниже 10 -6 мм рт.ст.) в области высоких температур (>200°С) по сравнению с прототипом и с другими известными теплоносителями (включая изученные к настоящему времени ИЖ), что обеспечивает их взрывобезопасность и значительно меньшую испаряемость в условиях динамического вакуума <1 мг⋅час -1 ⋅см -2 (200°С). Эти свойства полученных ИЖ позволяют использовать их в открытом космическом пространстве в качестве теплоносителей. Они также имеют физико-химические и теплофизические характеристики (вязкость, плотность, летучесть, теплоемкость и теплопроводность), необходимые для использования их в качестве теплоносителей. 1 табл., 6 пр.

ПРОИЗВОДНЫЕ МАЛОНОНИТРИЛА И ИХ ПРИМЕНЕНИЕ

... 1. Производное малононитрила, представленное формулой (I) где R1 представляет собой С1-С5-алкильную группу, необязательно замещенную, по меньшей мере, одним атомом галогена, С2-С5-алкенильную группу, необязательно замещенную, по меньшей мере, одним атомом галогена, С2-С5-алкинильную группу, необязательно замещенную, по меньшей мере, одним атомом галогена, или атом водорода; R2 представляет собой С1-С5-алкильную группу, необязательно замещенную, по меньшей мере, одним атомом галогена, С1-С5-алкоксигруппу, необязательно замещенную, по меньшей мере, одним атомом галогена, С2-С5-алкенильную группу, необязательно замещенную, по меньшей мере, одним атомом галогена, С2-С5-алкинильную группу, необязательно замещенную, по меньшей мере, одним атомом галогена, цианогруппу или атом водорода; каждый из R3 и R4 представляет собой С1-С5-алкильную группу, необязательно замещенную, по меньшей мере, одним атомом галогена, С2-С5-алкенильную группу, необязательно замещенную, по меньшей мере, одним атомом галогена ...

N-IMIDAZOLYLDERIVATE BIZYKLISCHER VERBINDUNGEN, DIE FUER DEN MEDIZINISCHEN BEREICH GEEIGNET SIND

BIOCIDAL IMIDAZOLYLPROPIONITRILE DERIVATIVES

SPRAYER & DIAPHRAGM PUMP

ISOHEXIDE-NUCLEOSIDE

2- 1-IMIDAZOLYL -PROPIONITRILES

IMIDAZOLE HYDRAZONE DERIVATIVES

Compounds as nuclear transport modulators and uses thereof

Provided are compounds of Formula I'-III', as well as their preparation and uses, and pharmaceutical compositions comprising these compounds and their uses as nuclear transport modulators. Provided are also uses of the compounds or pharmaceutical compositions in treating or preventing certain neurological disorders and diseases as well as certain types of cancer in humans.

BENZODIAZEPINE ANALOGS

New 2-oxo-tetrahydro-imidazole compounds and processes for preparing them

Compounds

Compounds of general formula (1): wherein R1, R2, R3, R4, R5 a , R* X1, X2, Z and Y are as defined herein are positive modulators of the N H calcium-activated chloride channel (CaCC), TMEM16A. The compounds are useful for treating diseases and conditions affected by modulation of TMEM16A, particularly respiratory diseases and conditions.

СПОСОБ ПОЛУЧЕНИЯ МОНОНИТРАТА СЕРТАКОНАЗОЛА И МОНОГИДРАТ МОНОНИТРАТА СЕРТАКОНАЗОЛА

Настоящее изобретение относится к способу получения мононитрата сертаконазола взаимодействием 1-(2,4-дихлорфенил)-2-(1Н-имидазол-1-ил)этанола с 3-бромметил-7-хлорбензо[b]тиофеном в присутствии гидросульфата тетрабутиламмония и гидроксида натрия в толуоле при 30-45°С. Полученное свободное основание сертаконазола переводят в моногидрат мононитрата сертаконазола, затем последний переводят в мононитрат сертаконазола. Описан и охарактеризован промежуточный продукт моногидрат мононитрата сертаконазола. Настоящий способ позволяет значительно упростить технологию процесса. 2 н. и 4 з.п. ф-лы, 5 ил., 2 табл.

ПРОИЗВОДНЫЕ ИМИДАЗОЛА ДЛЯ ЛЕЧЕНИЯ АЛЛЕРГИЧЕСКИХ ИГИПЕРПРОЛИФЕРАТИВНЫХ НАРУШЕНИЙ

ÐÎÑÑÈÉÑÊÀß ÔÅÄÅÐÀÖÈß (19) RU (11) 2005 134 670 (13) A (51) ÌÏÊ C07D 233/00 (2006.01) ÔÅÄÅÐÀËÜÍÀß ÑËÓÆÁÀ ÏÎ ÈÍÒÅËËÅÊÒÓÀËÜÍÎÉ ÑÎÁÑÒÂÅÍÍÎÑÒÈ, ÏÀÒÅÍÒÀÌ È ÒÎÂÀÐÍÛÌ ÇÍÀÊÀÌ (12) ÇÀßÂÊÀ ÍÀ ÈÇÎÁÐÅÒÅÍÈÅ (21), (22) Çà âêà: 2005134670/04, 09.04.2004 (71) Çà âèòåëü(è): ÀÂÀÍÈÐ ÔÀÐÌÀÑÜÞÒÈÊÀËÑ (US) (30) Êîíâåíöèîííûé ïðèîðèòåò: 10.04.2003 US 60/462.090 (43) Äàòà ïóáëèêàöèè çà âêè: 10.06.2006 Áþë. ¹ 16 (74) Ïàòåíòíûé ïîâåðåííûé: Öåòîâè÷ Íàòàëü Ëåîíèäîâíà (87) Ïóáëèêàöè PCT: WO 2004/091610 (28.10.2004) Àäðåñ äë ïåðåïèñêè: 125502, Ìîñêâà, óë. Ëàâî÷êèíà, 50-1, êâ.24, ïàò.ïîâ. Í.Ë. Öåòîâè÷ (54) ÏÐÎÈÇÂÎÄÍÛÅ ÈÌÈÄÀÇÎËÀ ÄËß ËÅ×ÅÍÈß ÀËËÅÐÃÈ×ÅÑÊÈÕ È (57) Ôîðìóëà èçîáðåòåíè 1. Ñîåäèíåíèå, èìåþùåå îäíó èç ñëåäóþùèõ ôîðìóë R U A 2 0 0 5 1 3 4 6 7 0 A ÃÈÏÅÐÏÐÎËÈÔÅÐÀÒÈÂÍÛÕ ÍÀÐÓØÅÍÈÉ Ñòðàíèöà: 1 RU 2 0 0 5 1 3 4 6 7 0 (86) Çà âêà PCT: US 2004/011010 (09.04.2004) R U (85) Äàòà ïåðåâîäà çà âêè PCT íà íàöèîíàëüíóþ ôàçó: 10.11.2005 (72) Àâòîð(û): ÑÈÐÊÀÐ Äæàãàäèø Ñ. (US), ÒÎÌÀÑ Ðè÷àðä Äæ. (US), ÐÈ×ÀÐÄÑ Ìàðê Ë. (US), ÊÕÀÒÓÈß Õåéðèïàäà (US) A 2 0 0 5 1 3 4 6 7 0 A R U 2 0 0 5 1 3 4 6 7 0 Ñòðàíèöà: 2 R U ãäå R âûáðàí èç ãðóïïû, ñîñòî ùåé èç âîäîðîäà, C1-C5 àëêèëà, áåíçèëà, ð-ôòîðáåíçèëà è äèàëêèëàìèíàëêèëà, à óïîì íóòûé C1-C5 àëêèë âûáðàí èç ãðóïïû, ñîñòî ùåé èç àëêèëà ñ ïð ìîé öåïüþ, ðàçâåòâëåííîãî àëêèëà èëè öèêëè÷åñêîãî àëêèëà, ãäå R3, X è Y íåçàâèñèìî âûáðàíû èç ãðóïïû, ñîñòî ùåé èç âîäîðîäà, ãàëîãåíà, àëêîêñè, çàìåùåííîé àëêîêñè, àëêèëà, çàìåùåííîãî àëêèëà, äèàëêèëàìèíîàëêèëà, ãèäðîêñèàëêèëà, ÎÍ, ÎÑÍ3, ÑÎÎÍ, CN, CF3, OCF3, NO2, COOR", ÑÍÎ è COR", ãäå R1 è R2 íåçàâèñèìî âûáðàíû èç ãðóïïû, ñîñòî ùåé èç âîäîðîäà, àëêèëà, çàìåùåííîãî àëêèëà, Ñ3-Ñ9 öèêëîàëêèëà, çàìåùåííîãî Ñ3-Ñ9 öèêëîàëêèëà, ïîëèöèêëè÷åñêèõ àëèôàòè÷åñêèõ ãðóïï, ôåíèëà, çàìåùåííîãî ôåíèëà, íàôòèëà, çàìåùåííîãî íàôòèëà, ãåòåðîöèêëîâ è çàìåùåííûõ ãåòåðîöèêëîâ, ïðè÷åì óïîì íóòûå ãåòåðîöèêëû è çàìåùåííûé ãåòåðîöèêëû ñîäåðæàò 1-3 ãåòåðîàòîìà, à óïîì íóòûå ãåòåðîàòîìû íåçàâèñèìî âûáðàíû èç ãðóïïû, ñîñòî ùåé èç àçîòà, êèñëîðîäà è ñåðû, ïðè÷åì ...

3-CARBONYL-1-AMINOALKYL-1H-INDOLE, VERWENDBAR ALS ANALGETIKA UND IHRE HERSTELLUNG.

Neue Diazacyloalkanverbindungen

SPRAYER AND DIAPHRAGM PUMP FOR IT

N-IMIDAZOLYL DERIVATIVES OF BICYCLIC COMPOUNDS USEFUL IN MEDICINE

A 1-pyridylimidazole derivative and its production and use

BENZODIAZEPINE DERIVATIVES

BENZIMIDAZOLE DERIVATIVES FOR ANTIULCERCOUS PURPOSES

1,3-DISUBSTITUTED IMIDAZOLES AND A PROCESS FOR THEIR PRODUCTION

ABSRACT OF THE DISCLOSURE This invention discloses novel 1,3-disubstituted imidazoles of the general formula (I) < IMG > (I) wherein A and B may be the same or different, and each is a straight- or branched-chain alkylene or alkenylene group having 1 to 8 carbon atoms, Y is an acyl group having 2 to 10 carbon atoms, an alkoxycarbonyl group having 2 to 7 carbon atoms or an dialkoxymethyl group having 3 to 13 carbon atoms, Z is a cyano group or an alkoxycarbonyl group having 2 to 7 carbon atoms, X is a halogen atom, n is zero or 1. These compounds are useful as intermediates for producing the imidazole derivatives of the general formula (V) < IMG > (V) wherein A and B are defined herebefore, zl is a carboxyl group or an alkoxycarbonyl group,n is zero or 1 which possess strong and specific inhibitory effects on thromboxane synthetase and thus are useful as therapeutical agents for treatment of diseases caused by thromboxane A2.

Halogen-free epoxy resin composition, prepreg, laminate and printed circuit board containing the same

The present invention relates to a halogen-free epoxy resin composition, a prepreg and a laminate containing the same. The halogen-free epoxy resin composition comprises 60 parts by weight of epoxy resin, from 15 to 28 parts by weight of benzoxazine resin, and from 10 to 20 parts by weight of styrene-maleic anhydride. The present invention discloses using from 15 to 28 parts by weight of benzoxazine resin and from 10 to 20 parts by weight of styrene-maleic anhydride to cure 60 parts by weight of epoxy resin, to ensure the Df stability of prepregs at different curing temperature conditions while maintaining low dielectric constant and low dielectric loss. The prepregs and laminates prepared from the resin composition have comprehensive performances, such as low dielectric constant, low dielectric loss, excellent flame retardancy, heat resistance, cohesiveness, low water absorption and moisture resistance, and are suitable for use in halogen-free multilayer circuit boards.

3,5-di-tert-butyl-4-hydroxyphenyl-substituted heterocyclic compound

Preparation method for imidazolphenyl amidine derivatives

Imidazolylphenyl amidine derivs (I) [R, R1, R3=H or alkyl; R2=alkyl, alkenyl, alkynyl, cyano, OH, (un)substd. cycloalkyl or cycloaliphatic alkyl, a bicyclic gp., aralkyl or aryl, or (un) substd. heterocyclic alkyl or heterocyclic gp. opt. contg. a further heteroatom , their tautomers and acid addn. salts are prepd. Thus, HCONHMe is reacted with 4-(4-aminophenyl)-1Himidazole and PhCOCl to give the resp. I (R=R1=R3=H, R2=Me). The amidines are useful as H2 receptor blockers which inhibit gastric secretion and are thus useful as antiulcer agents.

Fungicide

Process for preparing imidazolylpropionnitriles or their organic or inorganic acid salts

Способ получени  производных имидаэолнппропионнтрилов общей формулы ORi.К R-g-dH -l/J rl-KT J CN где R - фенил, незамещенный, моноили дизамещенный галогеном, Ci-C4 алкилом или -алкоксигруппой, R - Ci-Cj -алкил, -алкенил или фенилалкильный остаток, или их солей органических или неорганических кислот, отличающийс  тем, что соединение общей формулы OKiо R-C - 5Нго|с1Нз dN О где Rи R имеют указанные значени , подвергают взаимодействию с имидаСО золом в среде диметилформамида с вьделением целевого продукта в свободном виде или в виде соли органической или неорганической кислоты. The method of obtaining imidae derivatives of the general formula ORi. To Rg-dH -l / Jrl-KT J CN where R is phenyl, unsubstituted, mono-or disubstituted with halogen, Ci-C4 alkyl or -alkoxy, R-Ci-Cj-alkyl, -alkenyl or a phenylalkyl residue, or their organic or inorganic acid salts, characterized in that the compound of the general formula OKiO RC - 5H1O / C 1H 3 dN O where R and R have the indicated values, is reacted with imidASol in dimethylformamide to freeze the desired product in free form or in the form of organic salt or neor anicheskoy acid.

Process for preparing derivatives of imidazolyl phenylimidine or their salts

Способ получени  производных имидазрлилфениламидйна общей формулы 4-р HP -N C-N-R где 1) при О JL Н RI R и R J одинаковы или различны и означают атом водорода или метил, а Вз - алкил с числом атомов углерода 1-8, аллил, незаме-;, щенный или замещенный метилом, пренил, гидроксил, циклоалкил с числом атомов угле рода 3-6, незамещенный или замещенный метилом , бициклогептил, бензил, фурфурил, пропаргил . . . 2Упри О 3-р и г -N C-N-RZ I Н . . А-. , R и RI означают атом водорода иЛи метил а RZ - метил или циано, или их солей, отличающийс  тем, что соединение общей формулы R (Л л сн где А 3-В или 4 - В, i , где R и RI имеют указанные значени , О подвергают взаимодействию с соединением 00 эр общей формулы. . HjN-Rj . ND где На имеет указанные значени , в водной среде с последующим выделением целевого продукта в свободном виде или в виде соли. The method of obtaining imidazrlylphenylamidine derivatives of the general formula 4-p HP -N CNR where 1) when O JL H RI, R and RJ are the same or different and mean a hydrogen atom or methyl, and Bs - alkyl with 1-8 carbon atoms, allyl, , whelping or substituted by methyl, prenyl, hydroxyl, cycloalkyl with the number of carbon atoms of genus 3-6, unsubstituted or substituted by methyl, bicycloheptyl, benzyl, furfuryl, propargyl. . . 2Urti O 3-p and g -N C-N-RZ I H. . BUT-. , R and RI denote a hydrogen atom, and Li methyl and RZ is methyl or cyano, or their salts, characterized in that the compound of the general formula R (L nc where A 3-B or 4 is B, i, where R and RI have the indicated meaning, O is reacted with a compound of 00 er of the general formula H.N.-Rj. ND where H has the indicated values, in an aqueous medium, followed by isolation of the desired product in free form or as a salt.

Method for preparing 3,5-di-tert-butyl-4-hydroxyphenyl-substituted heterocyclic compound

내용 없음

Process for preparing imidazole compound

내용 없음

Method for purifying a ionic liquid and method for dehumidifying air

在100到200℃的温度和至多100mbar的压力下、在至少0.1h的期间内通过解吸挥发性化合物净化Q + A ? 结构的离子液体，其中Q + 为1，3?二烷基咪唑 离子，其中烷基彼此独立地为直链C 1 ?C 4 ?烷基，和A ? 为pK a 小于3的酸HA的阴离子。

Compositions and methods of treating infectious diseases of the oral cavity

FIELD: pharmaceutics. SUBSTANCE: group of inventions relates to compounds and pharmaceutical compositions for treating infectious diseases of the oral cavity. Disclosed is a compound of formula IX, or its enantiomers or stereoisomers. Also disclosed is a pharmaceutical composition containing an effective amount of the declared compound and a pharmaceutically acceptable carrier. (IX). EFFECT: group of inventions provides obtaining compounds for preventing and/or treating fungal infections, candidiasis or infectious diseases of the oral cavity. 4 cl, 10 dwg, 1 ex РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 2 770 033 C2 (51) МПК A61K 31/496 (2006.01) A61K 31/4196 (2006.01) C07D 405/14 (2006.01) C07C 69/60 (2006.01) A61P 31/10 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ОПИСАНИЕ ИЗОБРЕТЕНИЯ К ПАТЕНТУ (52) СПК A61K 31/496 (2021.08); A61K 31/4196 (2021.08); C07D 405/14 (2021.08); C07C 69/60 (2021.08); A61P 31/10 (2021.08) (21)(22) Заявка: 2019119103, 19.04.2017 19.04.2017 (73) Патентообладатель(и): ЦЕЛЛИКС БИО ПРАЙВЕТ ЛИМИТЕД (IN) Дата регистрации: 14.04.2022 28.11.2016 IN 201641040639 (43) Дата публикации заявки: 21.12.2020 Бюл. № 36 (56) Список документов, цитированных в отчете о поиске: WO 9843970 A1, 08.10.1998. WO 2014136086 A1, 12.09.2014. WO 2016087878 A1, 09.06.2016. WO 2015095346 A1, 25.06.2015. JAN HEERES et al, Conazoles, Molecules, 2010, no.15, p.4129-4188. (45) Опубликовано: 14.04.2022 Бюл. № 11 (86) Заявка PCT: IB 2017/052244 (19.04.2017) C 2 C 2 (85) Дата начала рассмотрения заявки PCT на национальной фазе: 19.06.2019 (87) Публикация заявки PCT: 2 7 7 0 0 3 3 WO 2018/096405 (31.05.2018) R U 2 7 7 0 0 3 3 Приоритет(ы): (30) Конвенционный приоритет: R U (24) Дата начала отсчета срока действия патента: (72) Автор(ы): КАНДУЛА, Махеш (IN) Адрес для переписки: 105215, Москва, а/я 26 Рыбина Н. А. (54) КОМПОЗИЦИИ И СПОСОБЫ ЛЕЧЕНИЯ ИНФЕКЦИОННЫХ ЗАБОЛЕВАНИЙ РОТОВОЙ ПОЛОСТИ (57) Реферат: Группа изобретений относится к области инфекций, кандидоза или ...

Malononitrile compound and use thereof

式(I)代表腈化合物。其对防治害虫高度有效，并因此用作害虫防治剂的活性成分。

Process for preparing isohexide nucleosides

An isohexide nucleoside of formula (I) and its pharmaceutically acceptable acid addn. salt is prepd. by reactiong a cpd. of formula (II) with a cpd. of formula B-H, and pref. removing protective gp. and reacting with phosphoring agent. In the formulas, R= H, C2-5 fatty acyl, benzyl or phosphate; B= 5 or 6 membered N-contd. heterocyclic aromatic gp.; R1= protective gp.; A= leaving gp. or atom. (I) is useful as a virus inhibitor.

Malononitrile compounds and use thereof

A nitrile compound represented by the formula (1). It is highly effective in controlling pests and is hence useful as an active ingredient for a pest control agent.

BENZIMIDAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND ANTI-ULCER AGENTS CONTAINING THEM

Compound and its preparation method and application

本发明提供了化合物及其制备方法和应用，该化合物为式I所示化合物或其对映异构体、非对映异构体、外消旋体、药学上可接受的盐、结晶水合物或溶剂合物。利用该化合物，能够用于在制备治疗癌症相关疾病的药物中的应用，尤其是用于在制备由间变性淋巴瘤激酶介导的非小细胞肺癌药物中的应用。在式I所示化合物中，R 1 、R 2 、R 3 、R 4 如说明书所定义。

Patent FR2519635B1

5-(6-alkylindol-3-ylmethylene)-1, 3-dimethyl-2- (methylimino)-4-imidazolidinones

ABSTRACT The invention relates to novel compounds of the formula

Process for obtaining benzodiazepine

hydrazone

ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE IMIDAZOLYLPHENYLAMIDINES.

Imidazolylphenyl amidines

Pentacyclic anion salt and use thereof as an electrolyte

Imidazole derivatives for treatment of allergic and hyperproliferative disorders

The preferred embodiments are directed to small molecule inhibitors of the IgE response to allergens, which are useful in the treatment of allergy and/or asthma or any diseases where IgE is pathogenic. The preferred embodiments also relate to imidazole molecules that are cellular proliferation inhibitors and thus are useful as anticancer agents. The preferred embodiments further relate to small molecules which suppress cytokines and leukocytes.

IMIDAZOL DERIVATIVES FOR THE TREATMENT OF ALLERGIC AND HYPERPROLIFERATIVE DISORDERS

Las realizaciones preferidas son pequenas moléculas inhibidoras de la respuesta de la IgE a alérgenos, que son útiles en el tratamiento de las alergias y/o el asma o cualquier enfermedad donde la IgE sea patogénica. Las realizaciones preferidas también se relacionan con moléculas de imidazol que son inhibidores de la proliferación celular y por lo tanto son útiles como agentes anticancerígeno. Las realizaciones preferidas además se relacionan con pequenas moléculas las cuales suprimen las citoquinas y los leucocitos. Reivindicación 1: Una composición farmacéutica para tratar o prevenir una reacción alérgica asociada con niveles incrementados de IgE o para inhibir la proliferación celular en un mamífero que comprende uno o más de cualquiera del resto de grupo de fórmulas (1), donde R se selecciona entre el grupo que consiste en H, alquilo C1-5, bencilo, p-fluorobencilo, y dialquilaminoalquilo, donde dicho alquilo C1-5 se selecciona entre el grupo que consiste en un alquilo de cadena lineal, ramificada o cíclica; donde R3, X y Y se seleccionan en forma independiente entre el grupo que consiste en H, halógeno, alcoxi, alcoxi, sustituido, alquilo, alquilo sustituido, dialquilaminoalquilo, hidroxialquilo, OH, OCH3, COOH, CN, CF3, OCF3, NO2, COOR'', CHO, y COR''; donde R1 y R2 se seleccionan en forma independiente entre el grupo que consiste en H, alquilo, alquilo sustituido, cicloalquilo C3-9, cicloalquilo C3-9 sustituido, grupos alifáticos policíclicos, fenilo, fenilo sustituido, naftilo, naftilo sustituido, heterociclo, y heterociclo sustituido, donde dicho heterociclo y dicho heterociclo sustituido contienen 1-3 heteroátomos, donde dicho heteroátomo se selecciona en forma independiente entre el grupo que consiste en nitrógeno, oxígeno y azufre; donde dichos sustituyentes se seleccionan entre el grupo que consisten en H, halógeno, alcoxi, alcoxi sustituido, alquilo, alquilo sustituido, dialquilaminoalquilo, hidroxialquilo, OH, OCH3, COOH, COOR', COR ...

BIOCIDE MEDIUM

Die Erfindung betrifft biozide Mittel fuer die Anwendung in der Landwirtschaft, im Material- und Vorratsschutz sowie auf dem Hygienesektor. Ziel der Erfindung ist die Bereitstellung neuer Mittel mit starker fungizider Wirkung und breitem Wirkungsspektrum. Erfindungsgemaesz werden in den neuen Mitteln als Wirkstoff Imidazolyl-propionitrile der allgemeinen Formel I angewandt, in der R einen gegebenenfalls ein- oder mehrfach, gleich oder verschieden durch Halogen, (C&ind1!-C&ind4!)-Alkyl, (C&ind1!-C&ind4!)-Alkoxy, (&ind1!-C&ind4!)-Alkylthio, Trifluormethyl oder die Nitrogruppe substituierten aromatischen Kohlenwasserstoffrest und R&ind1! (C&ind1!-C&ind10!)-Alkyl, (C&ind3!-C&ind8!)-Alkenyl, (&ind3!-C&ind8!)-Alkinyl oder einen gegebenenfalls ein- oder mehrfach, gleich oder verschieden durch Halogen, (C&ind1!-C&ind4!)-Alkyl, (C&ind1!-C&ind4!)-Alkoxy, (C&ind1!-C&ind4!)-Alkylthio, Trifluormethyl oder die Nitrogruppe substituierten Phenylalkylrest bedeuten. The invention relates to biocidal agents for use in agriculture, in material and storage protection and in the hygiene sector. The aim of the invention is the provision of new agents with a strong fungicidal action and a broad spectrum of activity. According to the invention, imidazolyl-propionitriles of general formula I are used as active ingredient in the new compositions, in which R is optionally mono- or polysubstituted, identically or differently, by halogen, (C 1 -C 4 -alkyl), (C 1 -C 4) -Alkoxy, (& ind1! -C & ind4!) - alkylthio, trifluoromethyl or the nitro group-substituted aromatic hydrocarbon radical and R & ind1! (C & ind1! -C & ind10!) - alkyl, (C & ind3! -C & ind8!) - alkenyl, (& ind3! -C & ind8!) - alkynyl or an optionally mono- or polysubstituted by identical or different halogen, (C & ind1! -C & ind4!) Alkyl, (C & ind1! -C & ind4) - alkoxy, (C & ind1! -C & ind4!) - ...

5-(indol-3-ylmethylene)-1,3-dimethyl-2-methylimino-4- imidazolidinone

ABSTRACT OF THE DISCLOSURE The invention relates to the novel 5-(indol-3--ylmethylene)-1,3-dimethyl-2-methylimino-4-imidazolidinone of the formula E-isomer or Z-isomer

IMIDAZOLYL PROPIONITRILES, SET FOR THE PREPARATION OF THESE COMPOUNDS AND BIOCIDA AGENTS CONTAINING THEM

Novel imidazole compound, synthesis of said compound, and method for rust prevention of metallic silver using said compound

5-nitro-thiazolyl-2-oxo-diazacyclo-alkane compounds and process for preparing same

MEDICINALLY EASY N-IMIDAZOLYL DERIVATIVES OF BICYCLIC COMPOUNDS

Malononitrile compound and use thereof

A nitrile compound shown by the formula (1) has an excel lent pesticidal activity and it is useful as an active ingredient of pesticide.

Imidazolylpropionitriles,process for the manufacture of these compounds and their use as biocidal agents

Process for preparing 3-carbonyl-1-aminoalkyl-1h-indoles

The title compds. (I; R2=H, alkyl, Cl, (un)substituted Ph, PhCH2; R3=cyclohexyl, alkoxycyclohexyl, biphenyl, thienyl, furyl, benzo(b) furyl, benzo(b)thienyl, quinolyl, styryl, naphthyl; R4=H, alkyl, OH, alkoxy, halo; Z=O, NOH; N:B=N3 azetidinyl, hexahydro-4H -1,4- diazepin-4-yl, morpholinyl, piperazinyl; (CH2)n=alkylene substd. on alpha- or w-carbon by alkyl); m=1,2; n=2-6) and their salts, useful as analgesic, antirhematic and antiinflammatory agents, were prepd.

Process for preparing derivatives of imidazolyl phenylimidine or their salts

Способ получени  производных имндаэо. лилфеииламидина общей формулы где R. - C;(-Cgi- алкнл. аллил. незамещенный илн замещенный метилом, прени ., пропаргил , Cj-C0 циклоалкнл, незамещенный или замещенный одной или двум  метальными труппами, фенил, бицнклогешнл. бензил, фурфурил: или их солей, о тличающнйс  тем, что 4-(аминофенил)-1Н-нмндазол формулы ИС С HN 1 ЦНг Чи подвергают взаимодействию с соединением общей формулы Фв I X ,, (У) где R имеет указанное значение; X - хлорид или фторборат; А - бензоилоксн или зтокси. или с его основанием с последующим выделе- g нием целевого продукта в свободном виде нли в виде соли. The method of obtaining imndaeo derivatives. lilpheylamidine of the general formula where R. is C; (—Cgi-alkyl. allyl. unsubstituted or substituted by methyl, pregeni., propargyl, Cj-C0 cycloalkyl, unsubstituted or substituted by one or two methyl groups, phenyl, benzyl, benzyl, furfuryl; or their salts, characterized by the fact that 4- (aminophenyl) -1H-nmnazole of the formula IC C HN 1 TsNg Chi is subjected to interaction with the compound of the general formula Fv IX ,, (Y) where R has the indicated value; X is chloride or fluoroborate; A - benzoyloxn or ztoxy. or with its base, followed by the release of the desired product into free NLI form a salt.

Dilithiated 2-(o-tolyl)-2-imidazolines

Imidazo[2,1-a]isoquinolines useful as anorexics and antidepressants are prepared from a dilithium derivative of a 2-(o-tolyl)-2-imidazoline.

Process for preparing 5-methyl-4-imidazolecarboxylic acid esters

A process for the preparation of 5-methyl-4-imidazolecarboxylic acid esters from acetoacetic acid esters. The products of this process are useful as intermediates for preparing cimetidine.

5-(6-Alkylindol-3-ylmethylene)-1,3-dimethyl-2-(methylimino)-4-imidazolidinones

5-(6-alkylindol-3-ylmethylene)-1,3-dimethyl-2-(methylimino)-4-imidazolidinones, prepared, inter alia, from the corresponding substituted indole-3-carboxaldehyde and dimethylcreatinine, are described. The imidazolidinones are useful as antidepressants.

Method for producing of benzimidazole derivatives

내용 없음. No content.

Reactive ionic liquid, ion-fixing metal oxide particles using same, ion-fixing elastomer, and transducer

本发明提供一种包含在含离子层中且作为在施加电压时向高电阻层的移动受到抑制的离子成分的反应性离子液体，所述含离子层是与作为转换器的介电层的高电阻层接触而形成的。制成包含以下阴离子成分与阳离子成分的离子对的反应性离子液体。其中，(a)阴离子成分：(a1)作为反应性基团而具有烷氧基甲硅烷基。(a2)作为阴离子基团而具有羧酸酯基(-COO - 基)或磺酸酯基(-SO 3 - 基)。(b)阳离子成分：(b1)包含咪唑鎓阳离子、铵阳离子、吡咯烷鎓阳离子、吗啉鎓阳离子、磷鎓阳离子中的任一种。(b2)不具有N-H基或P-H基。

Benzodiazepine derivatives and pharmaceutical compositions containing them

Benzodiazepine analogs of the formula: <CHEM> are disclosed which are antagonists of cholecystokinin (CCK). h

Compositions and methods for the treatment of oral infectious diseases

Portable sprayer with leak control and agitator

A pressure vessel for a backpack agricultural sprayer is mounted within a container of the sprayer and connected to the sprayer pump so that liquid from the container is forced under pressure into the pressure vessel for a spraying discharge therefrom. Leakage of liquid past the piston of the sprayer pump is contained by a leak proof diaphragm in a diaphragm chamber which is connected by a conduit to the interior of the sprayer container. The diaphragm is connected to the piston to be operated therewith thus providing two separate but simultaneously acting pumps. The first pump is the piston pump for pressurizing the liquid for spraying discharge. The second pump is the diaphragm which forces liquid back and forth between the container and the diaphragm chamber in a high velocity stream which agitates the contents as the stream is projected into the container interior.

Process for preparing 1,2 di-substituted-4-haloimidazole-5-acetic acid derivatives

Title compds. (I; R1 = H, nitro, amino; R2 = substituted phenyl, furyl, thienyl; R3 = H, lower alkyl; X = halogen), useful as diuretic, were prepd. by hydrolysis of compd.(II) or by alcoholysis with R3OH. Thus, the mixt. of 1-benzyl-2-(p-methoxyphenyl)-4-chloro-5-cyanomethylimidazole 2.8 g, conc HCl 15 ml, water 15 ml and glacial acetic acid 15 ml was refluxed for 5 hr, diluted with water 1l and then ice cooled to give 1-benzyl-2-(p-methoxyphenyl)-4-chloroimidazole-5-acetic acid 4 g. (m.p. 170-180≰C).

ISOHEXID-NUKLEOCID.

Process for the preparation of new 2-Arylhydrazino-imidazolinen- (2)

Benzodiazepine derivatives and pharmaceutical compositions containing them.

Benzodiazepine analogs of the formula: < CHEM > are disclosed which are antagonists of cholecystokinin (CCK). h

Mixed photoinitiators of hexaarylbisimidazoles and their uses

NOVEL ETHER-OXIDES DERIVED FROM CYCLOPROPYLPHENOLS

The present invention relates to imidazolines of general formula (I) (I) and the addition salts formed therefrom with the pharmaceutically acceptable mineral or organic acids, possibly having their own specific pharmacological properties. The invention further relates to the preparation of these products, to their use as new medicines and to the medicinal compositions containing them.

Hexaarylbisimidazole mixed photoinitiator

본 발명은 1-2’ 연결위치를 갖는 화학식 (I) 화합물 및 2’-3 연결위치를 갖는 화학식 (II) 화합물을 포함하고, 두 화합물의 함량 합은 혼합 광개시제의 97% 이상을 차지하는 2,2’-비스(o-클로로페닐)-4,4’,5,5’-테트라페닐디이미다졸 혼합 광개시제를 개시한다. 2,2’-비스(o-클로로페닐)-4,4’,5,5’-테트라페닐디이미다졸 혼합 광개시제는, 감광성 수지 조성물에 적용된 후, 감광도가 우수하고 해상도가 뛰어나 건식필름 및 습식필름의 방식으로 인쇄 회로 기판, 보호 패턴, 도체 패턴, 리드 프레임, 반도체 패키징 등의 제조 영역에 널리 응용될 수 있다. The present invention includes a compound of formula (I) having a 1-2' linking position and a compound of formula (II) having a 2'-3 linking position, and the sum of the contents of the two compounds accounts for 97% or more of the mixed photoinitiator 2, A 2'-bis(o-chlorophenyl)-4,4',5,5'-tetraphenyldiimidazole mixed photoinitiator is disclosed. The 2,2'-bis(o-chlorophenyl)-4,4',5,5'-tetraphenyldiimidazole mixed photoinitiator, after being applied to the photosensitive resin composition, has excellent photosensitivity and excellent resolution, making it suitable for use in dry film and wet film applications. As a film method, it can be widely applied to manufacturing areas such as printed circuit boards, protective patterns, conductor patterns, lead frames, and semiconductor packaging.

New Nltrothiazole Derivatives and Process for Their Preparation

Pentacyclic Anion Salt And Use Thereof As An Electrolyte

本发明涉及五元环阴离子盐及其用于电解质组合物中的用途。所述化合物包括化合价为m(1≤m≤3)的无机阳离子、有机阳离子或有机金属阳离子M和m个符合式(I)的阴离子 ，其中R f 是-CFZ'Z”基团，其中Z'是F或具有1到3个碳原子的全氟烷基；Z”是H、F或Cl基、具有1到5个碳原子的任选地氟化或全氟化的烷氧基、具有1到5个碳原子的任选地氟化或全氟化的氧杂烷氧基或具有1到5个碳原子的任选地氟化或全氟化的烷基；当Z’是F时，Z”不是F。本发明还涉及电解质组合物，该组合物包含所述盐在液体溶剂或聚合物溶剂中的溶液。

5-(indol-3-ylmethylene)-1,3-dimethyl-2-methylimino-4-imidazolynone

Novel compounds

New tetrahydro-imidazoles

ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTICALLY ACTIVE BENZODIAZEPINE ANALOGS

Imidazole hydrazone derivatives

ABSTRACT Compounds corresponding to the following general formula: wherein Ar and Ar1, which may be the same or different, each represents an aromatic radical which may be substituted one or more times by halogen and/or nitro and/or lower alkyl and/or trihalomethyl and/or cyano and/or lower alkoxy and/or di-lower akyl-amino, the alkyl groups optionally completing a ring optionally incorporating a further heteroatom, and/or lower alkyl sulphonyl; Alk1 and Alk2, which may be the same or different, each represents an alkylene group containing from one to eight carbon atoms which may be substituted one or more times by aryl an and/or cycloalkyl and/or lower alkyl and if two such alkyl groups are present, they may complete a ring optionally containing a heteroatom and in which imidazole ring may be further substituted; and m represents 0 or 1; provided that not both Ar and Ar1 represent phenyl; and acid addition salts thereof such compounds are prepared by reaction of a compound corresponding to the following general formula: with a compound of the formula: Ar1-NH-NH2 The compounds have an anti-fungal activity as well as an antianerobic and anti-thrombotic activity.

N-imidazolyl derivatives of pharmaceutical bicyclic compounds

내용 없음

Method of new imidazolylphenylamidines production

The object of the present invention are new pharmacologically active substituted imidazolylphenyl amidines as H 2 receptor blocking agents, which inhibit gastric acid secretion and which are useful antiulcer agents of the following formula in which R, R, and R 3 , which may be the same or different, represent a hydrogen atom or a lower alkyl group, and R 2 represents a linear or branched alkyl, alkenyl or alkynyl group, a cyano group, a hydroxyl group, a substituted or unsubstituted cycloalkyl or cycloaliphatic alkyl group, a bicyclic group, an aralkyl or aryl group (optionally substituted by halogen, a methyl, methoxy or methylenedioxy group) or a substituted or unsubstituted heterocyclicalkyl or heterocyclic group which may also contain a further hetero atom; and non-toxic acid addition salts thereof. The processes for the preparation of the compounds of formula and their intermediates as well as pharmaceutical compositions containing them are also object of this invention.

IMIDAZOLYL PROPIONITRILS, SET FOR THE PREPARATION OF THESE COMPOUNDS AND BIOCIDA MEDIUM-CONTAINING THEM

Novel imidazolylpropionitriles of the general formula <IMAGE> in which R represents an aromatic hydrocarbon radical that is unsubstituted or substituted by one of more of the same or different substituents selected from halogen atoms, (C1-C4)- alkyl, (C1-C4)-alkoxy and (C1-C4)-alkylthio radicals and trifluoromethyl and nitro groups, and R1 represents a (C1-C10)-alkyl, (C3-C8)-alkenyl, (C3-C8)-alkynyl or phenylalkyl radical each of which is unsubstituted or substituted by one or more of the same or different substituents selected from halogen atoms, (C1-C4)-alkyl, (C1-C4)-alkoxy and (C1-C4)-alkylthio radicals and trifluoromethyl and nitro groups, and their acid addition salts with inorganic and organic acids, possess a fungicidal, growth-regulating and bactericidal action.

New imidazole which can be used in therapy, in particular as an antischistosomal and antiamoebic agent.

New nitrothiazole derivatives and processes for their preparation

Pentacyclic anion salt and use thereof as electrolyte

Cyclic compounds

3-carbonyl-1-aminoalkyl-1h-indoles useful as analgesics and preparation thereof

AETHEROXIDE DERIVATIVES OF CYCLOPROPYLPHENOLS.

The present invention relates to imidazolines of general formula (I) <IMAGE> (I) and the addition salts formed therefrom with the pharmaceutically acceptable mineral or organic acids, possibly having their own specific pharmacological properties. The invention further relates to the preparation of these products, to their use as new medicines and to the medicinal compositions containing them.

Imidazole hydrazone derivative

Gold or gold alloy surface treatment solution

Benzodiazepine analogs and pharmaceutical compositions containing them

Benzodiazepine analogs of the formula: <CHEM> are disclosed which are antagonists of cholecystokinin (CCK). h

4-(5)-alkylmercaptoimidazole derivatives, a process for their production and medicaments containing these compounds

4-(5)-alkylmercaptoimidazole derivatives corresponding to the following general formula <IMAGE> in which R1 represents a methyl or ethyl group and X reprosents sulfur, an N-cyano group or a nitromethylene group, and their salts with pharmaceutically acceptable acids have activity as histamine antagonists.

Manufacture of phenylethyltriazole

Method for manufacturing imidazole compounds and salts and pseudopolymorphs thereof

本发明涉及生产舍他康唑一硝酸盐的方法。本发明还涉及舍他康唑一硝酸盐，其特征在于粒径，还涉及舍他康唑一硝酸盐一水化物。

Method for preventing rusting in silver by using novel imidazole-4(5)-dithiocarboxylic acids in organic solvent

Disclosed is an imidazole-4(5)-dithiocarboxylic acid compound represented by the following general formula: ##STR1## wherein R 2 stands for a hydrogen atom or a monovalent hydrocarbon group having up to 20 carbons, R 4 stands for a hydrogen atom or an alkyl group having up to 4 carbon atoms, and X stands for a hydrogen atom or an alkali metal atom. This compound has an excellent rust preventive action to silver. This compound is prepared according to a process which comprises reacting an imidazole compound represented by the following general formula: ##STR2## wherein R 2 and R 4 are as defined above, with carbon disulfides and an alkali metal hydroxide in the presence of a solvent, and if necessary, acidifying the obtained imidazole compound.

Imidazole derivatives for treatment of allergic and hyperproliferative disorders

The preferred embodiments are directed to small molecule inhibitors of the IgE response to allergens, which are useful in the treatment of allergy and/or asthma or any diseases where IgE is pathogenic. The preferred embodiments also relate to imidazole molecules that are cellular proliferation inhibitors and thus are useful as anticancer agents. The preferred embodiments further relate to small molecules which suppress cytokines and leukocytes.

Resin composition, cured product, laminate, method for producing cured product, semiconductor device, and compound

환화 수지 및 그 전구체로 이루어지는 군으로부터 선택되는 적어도 1종의 수지, 및, 연결기를 개재하여 서로 결합되어 있는 중합성기와 아마이드 결합을 갖는 중합성 화합물을 포함하고, 상기 아마이드 결합은 상기 연결기와 카보닐기 측에서 결합되어 있으며, 상기 중합성 화합물을 이용하여 단일 중합체를 합성한 경우, 상기 단일 중합체는 250℃의 가열에 의하여 주쇄로부터 유리되는 염기를 발생하는 성질을 나타내는 수지 조성물, 상기 수지 조성물을 경화하여 이루어지는 경화물, 상기 경화물을 포함하는 적층체, 상기 경화물의 제조 방법, 및, 상기 경화물 또는 상기 적층체를 포함하는 반도체 디바이스, 및, 신규 화합물.

Hexaarylbiimidazole hybrid photoinitiator and application

A hexaarylbiimidazole hybrid photoinitiator, having a structure as represented by formula (I), and containing a biimidazole compound having four attachment sites, i.e., 1'-2, 2-3', 1-2' and 2'-3. The total mass percentage content of the biimidazole compound having the four attachment positions in the hybrid photoinitiator is above 92%. Ar 1 , Ar 2 , Ar 3 , Ar 4 , Ar 5 , and Ar 6 in the formula (I) each independently represents a substituted or unsubstituted aryl group. A photosensitive resin composition containing the hexaarylbiimidazole hybrid photoinitiator has good compatibility, excellent photosensitivity, and a small amount of developing waste, and can be widely used in the forms of a dry film and a wet film.

Compounds of [1,2,4] triazole and imidazole substituted as fungicides.

Alpha-adrenoreceptor agonistic 2-[(2-cyclopropyl-5-methyl- or 2-cyclopropyl-5-chlorophenoxy)methyl]-2-imidazolines

The present invention relates to imidazolines of general formula (I) ##STR1## and the addition salts formed therefrom with the pharmaceutically acceptable mineral or organic acids, possibly having their own specific pharmacological properties. The invention further relates to the preparation of these products, to their use as new medicines and to the medicinal compositions containing them.

1-square bracket to 5-nitrothiazolyl- (2) square bracket to -2oxo-hexahydropyrimidine

Compounds

Process for manufacturing of pyrrolidines derivatives

Pyrrolidin derivs of formula (I) and their acid addn. salts are prepd by removing a protective gp. of Z from a compd. of formula (II). In the formulas, R2 is H or lower alkyl; R3 is H, lower alkyl or -(CH2)nNR4R5; R4 and R5 are each H or lower alkyl; NR4R5 is pyrrolidino, piperidino, piperazino or morpholino substd. by 1 or 2 lower alkyl gps.; n is 2-4. (I) are useful for curing and preventing a cerebral insufficiency, and improving an intellectual ability.

Process for preparing 2,6-disubstituted 2-phenyl-imido-imidazolidines

Title compd. (I, Z = 2-ethyl-6 methylpheny1, 2-chloro-6-fluouophenyl, 2, 6-ditrifluoromethoxyphenyl, 2-bromo-6-chloro-phenyl, 2-chloro-6-trifluoro-methylphenyl or 2-fluoro-6-trifluoromethylphenyl) and its salt, useful as anti-hypertensive, was prepd. by treating compd. II (X and Y are same or not, halogen, sulfohydryl, hydroxy, amino, C1-4 alkylthio, alkoxy) with ethylenediamine. Thus, 332 g N-(2-ethyl-6-methylphenyl) -s-methylisothouronium hydroiodide and 96 ml ethylenediamine were heated to 150≰C for 20 min in oil bath gave 32.4 g 2-(2-ethyl-6-methylphenylamino)-imdazolidine.

IMMIDAZOLIL-PROPIONITRILI, PROCEDURE FOR THE PREPARATION OF THESE COMPOUNDS AS WELL AS BIOCIDAL MEDIA CONTAINING THEM

Patent FR4613M