23-01-2014 дата публикации
Номер: US20140024690A1
The present invention is directed to a new class of hydroxamic acid derivatives, their use as LpxC inhibitors and, more specifically, their use to treat bacterial infections. 2. The compound according to wherein{'sup': '1', 'sub': 1', '3, 'Ris (C-C)alkyl;'}{'sup': '2', 'sub': 1', '3, 'Ris (C-C)alkyl;'}{'sup': '3', 'Ris hydrogen;'}{'sub': 2', 'n', '2', 'n', '2', 'p', '2', 'n', '2', 'p', '2', 'n', '2', 'p', '2', 'n', '2', '2', 'p', '2', 'n', '2', 'p', '2', 'n', '2', 'p, 'sup': 4', '4', '4', '4, 'L is a bond, —(CH)—, —(CH)O(CH)—, —(CH)S(CH)—, —(CH)NR(CH)—, —(CH)SONR(CH)—, —(CH)CONR(CH)—, or —(CH)NRCO(CH)—;'}{'sup': 4', '5, 'sub': 1', '6', '3', '8, 'Rand Rare independently hydrogen, (C-C)alkyl, or (C-C)cycloalkyl;'}n is 0, 1, or 2;p is 0, 1, or 2;{'sup': 6', '4', '5, 'sub': 1', '6', '1', '6', '1', '6', '1', '6', '6', '12', '6', '12', '3', '8', '5', '12', '1', '10, 'Ris (C-C)alkoxy(C-C)alkyl, (C-C)alkoxycarbonyl, (C-C)alkylthiocarbonyl, (C-C)aryl, (C-C)aryloxy, (C-C)cycloalkyl, (C-C)heteroaryl, hydroxy(C-C)alkyl, or (NRR)carbonyl; and'}{'sup': '7', 'sub': 3', '13, 'Ris absent or (C-C)heterocycle.'}3. The compound according to wherein{'sup': '1', 'Ris methyl;'}{'sup': '2', 'Ris methyl;'}{'sup': '3', 'Ris hydrogen;'}{'sub': 2', 'n', '2', 'n', '2', 'p', '2', 'n', '2', 'p', '2', 'n', '2', 'p', '2', 'n', '2', '2', 'p', '2', 'n', '2', 'p', '2', 'n', '2', 'p, 'sup': 4', '4', '4', '4, 'L is a bond, —(CH)—, —(CH)O(CH)—, —(CH)S(CH)—, —(CH)NR(CH)—, —(CH)SONR(CH)—, —(CH)CONR(CH)—, or —(CH)NRCO(CH)—;'}{'sup': '4', 'sub': 1', '6', '3', '8, 'Ris hydrogen, (C-C)alkyl, or (C-C)cycloalkyl;'}n is 0, 1, or 2;p is 0, 1, or 2;{'sup': '6', 'sub': 6', '12', '6', '12', '6', '12', '1', '6', '1', '6', '1', '6, 'Ris (C-C)aryl or (C-C)aryloxy, wherein the (C-C)aryl group for each is phenyl optionally substituted with 1, 2, or 3 substituents that are independently (C-C)alkoxy, (C-C)alkyl, halo(C-C)alkoxy, halogen, or methylenedioxy; and'}{'sup': '7', 'sub': 3', '13', '3', '13, 'Ris absent or (C-C) ...
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