ПРОИЗВОДНЫЕ 2-ФЕНОКСИ И 2-ФЕНИЛСУЛЬФОНАМИДА С ССR3 АНТАГОНИСТИЧЕСКОЙ АКТИВНОСТЬЮ ДЛЯ ЛЕЧЕНИЯ АСТМЫ И ДРУГИХ ВОСПАЛИТЕЛЬНЫХ ИЛИ ИММУНОЛОГИЧЕСКИХ ЗАБОЛЕВАНИЙ

... 1. Производное бензолсульфонамида, имеющее формулу (I), его таутомерные и стереоизомерные формы и его соли где Х представляет О или S; R1 представляет водород, галоген, гидрокси, нитро, циано, С1-6алкоксикарбонил, амино, С1-6алкиламино, ди(С1-6алкил)амино, С1-6алканоил, фенил, С1-6алкил, необязательно замещенный одним, двумя или тремя галогенами, или С1-6алкокси, необязательно замещенный одним, двумя или тремя галогенами; R2 представляет водород, галоген, гидрокси, нитро, циано, С1-6алкоксикарбонил, С1-6алкиламино, ди(С1-6алкил)амино, С1-6 алканоил, фенил, С1-6алкил, необязательно замещенный одним, двумя или тремя галогенами, или С1-6алкокси, необязательно замещенный одним, двумя или тремя галогенами; R3 представляет водород, галоген, гидрокси, нитро, циано, амино, карбокси, тетразолил, С1-6алкокси, С1-6алкоксикарбонил, С1-6алканоил, С1-6 алканоиламино, С1-6алкил, необязательно замещенный одним, двумя или тремя галогенами или гидрокси; R4 представляет или где R40 представляет С1-6алкил, ...

BORIDE CATALYST FOR EPOXIDIZING OLEFINIC COMPOUNDS

PROCEDURE FOR EPOXYDIERUNG OF CYCLODODECEN OR TRICYCLODECEN-3.

Benzenesulfonamide derivatives

PROCESS FOR OXIDATION OF OLEFINICALLY-UNSATURATED COMPOUNDS

K 541 PROCESS FOR OXIDATION OF OLEFINICALLY-UNSATURATED COMPOUNDS The invention provides a process for epoxidising an olefinic double bond in an olefinically-unsaturated compound other than an (.alpha.,.beta.)-unsaturated carboxylic acid or a compound containing a sixmembered ring wherein 3 to 4 member atoms are carbon atoms having sp2 hybrid orbitals, by treatment of a liquid phase mixture of the olefinically-unsaturated compound, an aldehyde containing at least two carbon atoms and a suitable solvent with oxygen in the presence of a catalyst which is soluble in the reaction mixture and which comprises a praseodymium compound. The process has particularly advantageous application to oxidation of aldrin to dieldrin.

Procédé de préparation des époxy-dérivés du cyclopentanonaphtalène

Verfahren zur Herstellung neuer, in Stellung 5 substituierter 5H-Dibenzo-(a,d)cycloheptene

Verfahren zur Herstellung neuer, in Stellung 5 substituierter 5H-Dibenzo(a,d)cycloheptene

Tricyclic aliphatic cpds - for use as aroma agents

Cpds. have the general formula (in which Z is gps. (a) and X is gps. (e) -CH2- or (j) - CH - CH = CH-R; where R is H or 1-6C alkyl, and R' is H or a lower acyl). Pref. cpds. I (bf), I (bg), I (bh), I (ah), I (bi), and I (bj). These cpds. are chemically stable, have scent with woody, fruity or 'green' nuances, and can be used in foodstuffs, drinks, tobacco, pharmaceuticals, perfumes and cosmetics.

Tricyclic aliphatic cpds - for use as aroma agents

Verfahren zur Herstellung von Tricyclo-(4,3,1,13,8)-undecan-4-on

Tricyclic aliphatic cpds - for use as aroma agents

Cpds. have the general formula (in which Z is gps. (a) and X is gps. (e) -CH2- or (j) - CH - CH = CH-R; where R is H or 1-6C alkyl, and R' is H or a lower acyl). Pref. cpds. I (bf), I (bg), I (bh), I (ah), I (bi), and I (bj). These cpds. are chemically stable, have scent with woody, fruity or 'green' nuances, and can be used in foodstuffs, drinks, tobacco, pharmaceuticals, perfumes and cosmetics.

1,2,6-Trimethyltricyclododeca-5-ene useful as a perfume intermediate

1,2,6-Trimethyltricyclododeca-5-ene useful as a perfume intermediate produced from trimethylcyclo-dodecatriene-1,5,9by intramol ring closure

HYDROXYL TRICYCLIC COMPOUNDS AND THEIR USE AS PERFUMING INGREDIENTS.

TRICYCLIC EPOXIDE AND ITS USE AS PERFUMING INGREDIENT.

PROCEDURE FOR THE PRODUCTION OF OXYGENIERTEN MONOTERPENOIDEN HYDROCARBONS.

Tricyclic hydrocarbon and process for producing the same

Epoxy Polycyclopentadienes and their method of preparation

Tricyclic hydrocarbon and process for producing the same

Process for the manufacture of oxygenated monoterpenoid hydrocarbons

a) Process for the manufacture of oxygenated monoterpenoid hydrocarbons. b) Process, characterised in that terpenes of general formula (I), in which R1 to R5, which can be identical or different, represent hydrogen, an alkyl or an alkenyl and in which R1 and R5 or R2 and R5 radicals can also form a cycloalkyl or cycloalkenyl ring, are dissolved in an organic solvent and in that the latter are oxidised with air, as the oxygen source, under the effect of electromagnetic radiation in the wavelength region ranging from 200 to 800 nm in the presence of ferric, manganic or molybdic tetraphenylporphyrins as catalyst at temperatures between 10 and 60 DEG C with air or oxygen.

BENCENOSULFONAMIDA DERIVATIVES

Los derivados de bencenosulfonamida tienen actividad antagonista de CCR3 (receptor de quimioquina de tipo CC), y pueden utilizarse para la profilaxis y el tratamiento de enfermedades asociadas a la actividad CCR3, en particular para el tratamiento de asma, dermatitis atópica, rinitis alérgica y otros trastornos inflamatorios/inmunológicos. Reivindicación 1: Un derivado de bencenosulfonamida de fórmula (1), su forma tautomérica o estereoisomérica, o una sal del mismo, en la que: X representa O o S; R1 representa hidrógeno, halógeno, hidroxi, nitro, ciano, alcoxi(C1-6) carbonilo, amino, alquil(C1-6) amino, di(alquil (C1-6))amino, alcanoilo C1-6, fenilo, alquilo C1-6 opcionalmente sustituido con mono-, di- o trihalógeno, o alcoxi C1-6 opcionalmente sustituido con mono-, di- o trihalógeno; R2 representa hidrógeno, halógeno, hidroxi, nitro, ciano, alcoxi(C1-6) carbonilo, amino, alquil(C1-6) amino, di(alquil (C1-6))amino, alcanoilo C1-6, fenilo, alquilo C1-6 opcionalmente sustituido con mono- ...

СПОСОБ ПОЛУЧЕНИЯ 3,16,19-ТРИОКСАГЕКСАЦИКЛО[10.5.3.0.0.0.0]ИКОС-13-ЕНА, ПРОЯВЛЯЮЩЕГО ПРОТИВООПУХОЛЕВУЮ АКТИВНОСТЬ

FIELD: pharmaceuticals.SUBSTANCE: invention relates to a method of producing 3,16,19-trioxahexacyclo[10.5.3.0.0.0.0]icos-13-ene. Method involves interaction tricyclo[9.4.2.0]geptadeka-2,12,14,16-tetraene (CH) with m-chloroperoxybenzoic acid (m-CPBA) in molar ratio CH:m-CPBA=2:(10–20) at 0–40 °C in dichloromethane for 3–23 hours. Invention also relates to 3,16,19-trioxahexacyclo[10.5.3.0.0.0.0]icos-13-ene, exhibiting anti-tumor activity.EFFECT: disclosed is a method of producing 3,16,19-trioxahexacyclo[10_5_3_0_0_0_0]icos-13-ene, exhibiting antitumour activity.2 cl, 2 tbl, 2 ex РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 2 726 355 C1 (51) МПК C07D 301/14 (2006.01) C07D 303/06 (2006.01) A61K 31/336 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ОПИСАНИЕ ИЗОБРЕТЕНИЯ К ПАТЕНТУ (52) СПК C07D 301/14 (2020.02); C07D 303/06 (2020.02); A61K 31/336 (2020.02) (21)(22) Заявка: 2019104498, 18.02.2019 (24) Дата начала отсчета срока действия патента: Дата регистрации: 13.07.2020 (45) Опубликовано: 13.07.2020 Бюл. № 20 2 7 2 6 3 5 5 R U (56) Список документов, цитированных в отчете о поиске: V.A. D’YAKONOV et al., Cobalt(I)сatalyzed [6π+2π]-сycloadditions of 1,2-dienes to 1,3,5,7-cyclooctatetraene, TETRAHEDRON LETT., 2015, V.56, N.15, P.2005-2007. RU 2017110613 A, 29.03.2017. В.А. ДЬЯКОНОВ и др. Каталитическое [6π+2π]циклоприсоединение 1,2-диенов к бис(циклогепта-1,3,5-триен-7-ил)алканам при действии Ti(acac)2Cl2-Et2AlCl, ЖУРНАЛ (см. прод.) (54) СПОСОБ ПОЛУЧЕНИЯ 3,16,19-ТРИОКСАГЕКСАЦИКЛО[10.5.3.0 2,4 .0 2,11 .0 15,17 .0 18,20 ]ИКОС13-ЕНА, ПРОЯВЛЯЮЩЕГО ПРОТИВООПУХОЛЕВУЮ АКТИВНОСТЬ (57) Реферат: Изобретение относится к способу получения мольном соотношении С17Н22:m-СРВА=2:(10-20) 3 , 1 6 , 1 9 - т р и о к с а г е к с а ц и к л о при 0-40°С в дихлорметане в течение 3-23 ч. [10.5.3.02,4.02,11.015,17.018,20]икос-13-ена. Сущность способа заключается во взаимодействии трицикло Изобретение относится также к самому 3,16,19т р и о к с а г е к с а ц и к л о [9.4.2.02,10] ...

EPOXIDES

... 1363404 Epoxides L GIVAUDAN & CIE SA 19 March 1973 [20 March 1972] 13054/73 Heading C2C [Also in Divisions A5 and C5] The invention comprises 4,4a-epoxy-6,8aethano - 1,1,6 - trimethyl - decahydronaphthalene and 4,4a - epoxy - 7,8a - ethano - 1,1,7- trimethyl - decahydronaphthalene. The compounds are prepared by epoxidizing the appropriate octahydronaphthalenes.

Tricyclic aliphatic cpds

Tricyclic aliphatic cpds

Cpds. have the general formula (in which Z is gps. (a) and X is gps. (e) -CH2- or (j) - CH - CH = CH-R; where R is H or 1-6C alkyl, and R' is H or a lower acyl). Pref. cpds. I (bf), I (bg), I (bh), I (ah), I (bi), and I (bj). These cpds. are chemically stable, have scent with woody, fruity or 'green' nuances, and can be used in foodstuffs, drinks, tobacco, pharmaceuticals, perfumes and cosmetics.

2-PHENOXY- AND 2-PHENYLSULFOMAMIDE DERIVATIVES WITH CCR3 ANTAGONISTIC ACTIVITY FOR THE TREATMENT OF ASTHMA AND OTHER INFLAMMATORY OR IMMUNOLOGICAL DISORDERS

The present invention relates to a benzenesulfonamide derivative of formula (I), which is useful as an active ingredient of pharmaceutical preparations. The benzenesulfonamide derivatives of the present invention have CCR3 (CC type chemokine receptor) antagonistic activity, and can be used for the prophylaxis and treatment of diseases associated with CCR3 activity, in particular for the treatment of asthma, atopic dermatitis, allergic rhinitis and other inflammatory/immunological disorders. In said formula, X represents O or S; R represents formulae (a), (b), (c), (d), (e), (f), (g), (h), (i) or (j), the other substituents are as defined in claim 1.4 © KIPO & WIPO 2007 ...

Method for preparing alicyclic type epoxy (meth) acrylic acid esters

A new compound that has 3, 4-epoxytricyclo[5.2.1.02, 6]decane frame and the polymerization unsaturated bonding and the process of manufacture thereof are provided. Moreover, it is characterized by the copolymer consisting of unit of (A) alkali solubility radical containing monomer and (B) monomer corresponding to epoxy radical containing polymerization unsaturated compound, alternatively, in addition to the above-mentioned monomer (A) and (B), the copolymer comprising the epoxy radical non-containing polymerization unsaturated compound corresponding to N-substituted maleimide and the like, wherein the ratio of above-mentioned monomer unit(B) is 40 to 90% by weight, based on the unit of total monomers, and in the above-mentioned monomer unit (B), 30% or above of which is a monomer corresponding to the specific 3, 4-epoxytricyclo[5.2.1.02, 6]decane frame containing compound. By using the said copolymer, the preservation stability of the resin composition including the resin ...

Method for producing ethylene carbonate and ethylene glycol

A method for producing ethylene carbonate comprises the steps of obtaining a reaction solution containing ethylene carbonate by reacting carbon dioxide and ethylene oxide in the presence of a catalyst and purifying produced ethylene carbonate by means of crystallization, the method comprising extracting a solution containing the catalyst from the reaction solution, adding water to the extracted solution in an amount of not less than 20 times by weight an amount of the catalyst dissolved in the extracted solution to deposit undissolved matters, removing the deposited undissolved matters from the extracted solution, and then circulating the solution to the reaction solution. Accordingly, it is possible to efficiently produce ethylene carbonate from which any colored component is removed. Further, in an ethylene glycol production process, the operation can be performed stably for a long period of time while avoiding the clog-up or blockade.

ФЛУОРЕНОВЫЕ ПРОИЗВОДНЫЕ

ÐÎÑÑÈÉÑÊÀß ÔÅÄÅÐÀÖÈß (19) RU (11) 2006 107 371 (13) A (51) ÌÏÊ C07C 279/22 (2006.01) ÔÅÄÅÐÀËÜÍÀß ÑËÓÆÁÀ ÏÎ ÈÍÒÅËËÅÊÒÓÀËÜÍÎÉ ÑÎÁÑÒÂÅÍÍÎÑÒÈ, ÏÀÒÅÍÒÀÌ È ÒÎÂÀÐÍÛÌ ÇÍÀÊÀÌ (12) ÇÀßÂÊÀ ÍÀ ÈÇÎÁÐÅÒÅÍÈÅ (21), (22) Çà âêà: 2006107371/04, 17.02.2005 (71) Çà âèòåëü(è): ÀÑÒÅËËÀÑ ÔÀÐÌÀ ÈÍÊ. (JP) (30) Êîíâåíöèîííûé ïðèîðèòåò: 20.02.2004 JP 2004-044122 (43) Äàòà ïóáëèêàöèè çà âêè: 10.09.2006 Áþë. ¹ 25 (87) Ïóáëèêàöè PCT: WO 2005/080322 (01.09.2005) Àäðåñ äë ïåðåïèñêè: 129010, Ìîñêâà, óë. Á.Ñïàññêà , 25, ñòð.3, ÎÎÎ "Þðèäè÷åñêà ôèðìà Ãîðîäèññêèé è Ïàðòíåðû", ïàò.ïîâ. Ã.Á. Åãîðîâîé (74) Ïàòåíòíûé ïîâåðåííûé: Åãîðîâà Ãàëèíà Áîðèñîâíà R U (57) Ôîðìóëà èçîáðåòåíè 1. Ôëóîðåíîâîå ïðîèçâîäíîå, ïðåäñòàâëåííîå ñëåäóþùåé îáùåé ôîðìóëîé (I), èëè åãî ôàðìàöåâòè÷åñêè ïðèåìëåìà ñîëü A 2 0 0 6 1 0 7 3 7 1 A (54) ÔËÓÎÐÅÍÎÂÛÅ ÏÐÎÈÇÂÎÄÍÛÅ (ñèìâîëû â ôîðìóëå èìåþò ñëåäóþùèå çíà÷åíè : R 1 è R 2 âë þòñ îäèíàêîâûìè èëè îòëè÷íûìè äðóã îò äðóãà, è êàæäûé ïðåäñòàâë åò ñîáîé -R 0, íèçøèé àëêåíèë, íèçøèé àëêèíèë, ãàëîãåí, -OH, -O-R 0, -OCO-R 0, -NH2, -NR 6-R 0, -CN, -NO2, -CHO, -CONH2, -CONR 6-R 0, -CO2H, -CO2-R 0, -CO-R 0, -NR 6-CO-R 0, -NR 6-CO2-R 0, -O-CO-NR 6-R 0, -SH, -S(O)p-R 0, -S(O)2-NH2, -S(O)2-NR 6-R 0, -NR 6-S(O)2-R 0, -R 00-OCO-R 0, -R 00-NR 6-R 0, -R 00-CN, -R 00-CONH2, -R 00-CONR 6-R 0, -R 00-CO2H, -R 00-CO2-R 0, -R 00-CO-R 0, -R 00-NR 6-CO-R 0, -R 00-NR 6-CO2-R 0, -R 00-O-CONR 6-R 0, öèêëîàëêèë èëè àçîòñîäåðæàùèé íàñûùåííûé ãåòåðîöèêë, ãäå óêàçàííûé àçîòñîäåðæàùèé íàñûùåííûé ãåòåðîöèêë ìîæåò áûòü çàìåùåí 1 èëè 2 çàìåñòèòåë ìè, âûáðàííûìè èç ãðóïïû, âêëþ÷àþùåé íèçøèé àëêèë, -OH, -O-R 0, -NH2, -NR 6-R 0 è îêñî (=O); R 0 âë þòñ îäèíàêîâûìè èëè îòëè÷íûìè äðóã îò äðóãà, è êàæäûé ïðåäñòàâë åò ñîáîé íèçøèé àëêèë, êîòîðûé ìîæåò áûòü çàìåùåí îäíèì èëè íåñêîëüêèìè çàìåñòèòåë ìè, Ñòðàíèöà: 1 RU 2 0 0 6 1 0 7 3 7 1 (86) Çà âêà PCT: JP 2005/002950 (17.02.2005) R U (85) Äàòà ïåðåâîäà çà âêè PCT íà íàöèîíàëüíóþ ôàçó: 09.03.2006 (72) Àâòîð(û): ßÌÀÄÀ Õèðîéîñè (JP), ÈÒÀÕÀÍÀ Õèðîöóíå (JP), ÌÎÐÈÒÎÌÎ Àéàêî (JP), ...

Mischungen ungesättigter makrocyclischer Epoxide als Riechstoffe

Isomerengemisch von Isomeren von 17-Oxabicyclo[14.1.0]heptadec-8-en, mit einem Anteil an einem (E)-17-Oxabicyclo[14.1.0]heptadec-8-en-Isomer (1) und/oder (2), dadurch gekennzeichnet, dass a) wenn das Isomerengemisch vier Isomere (1), (2), (3) und (4) enthält, der Anteil an Isomer (1) größer als 32 Gew.-% ist und/oder der Anteil an Isomer (2) größer als 12 Gew.-% ist, b) wenn das Isomerengemisch nur zwei oder drei Isomere ausgewählt aus den Isomeren (1), (2), (3) und (4) enthält, der Anteil an Isomer (1) und/oder Isomer (2) zumindest 45 Gew.-% beträgt, jeweils bezogen auf das Gesamtgewicht des Isomerengemischs.

Polyzyklische Aromaten Ringspaltungsverfahren

Organic compounds

TRICYCLIC HYDROCARBON AND PROCESS FOR PRODUCING THE SAME

TRICYCLIC HYDROCARBONS AND PRODUCTION THEREOF

CYCLOALIPHATIC COMPOUNDS AS ODOUR AND TASTEMODIFYING AGENTS

Procédé de fabrication d'hydrocarbures oxygénés mono-terpenoïdes.

... a) Procédé de fabrication d'hydrocarbures mono-terpénoïdes oxygénés. b) Procédé caractérisé en ce que l'on dissout des terpènes de formule générale (I) dans laquelle R1 à R5 , qui peuvent être identiques ou différents, représentent de l'hydrogène, un alcoyle ou un alcényle et dans laquelle les radicaux R1 et R5 ou R2 et R5 peuvent former également un cycle cycloalcoyle ou cycloalcényle, dans un solvant organique et que l'on oxyde ceux-ci par l'air pour l'oxygène sous action d'un rayonnement électromagnétique dans la zone des longueurs d'onde allant de 200 à 800 nm en présence de tétraphénylporphyrines ferriques, manganiques ou molybdéniques comme catalyseur à des températures entre 10 et 60degré C avec de l'air ou de l'oxygène. (CF DESSIN DANS BOPI) ...

WORKING METHOD FOR PREPARING cyclopentaananimenCYCLOPENTAANANIMEN AS WELL AS OF THESE CONNECTIONS CONTAINING RESOURCES

2-PHENOXYUND 2-PHENYLSULFANYL-BENZENESULFONAMID of DERIVATIVES WITH CCR3 of ANTAGONISTIC ACTIVITY FOR the TREATMENT OF ASTHMA AND OTHER INFLAMMATORY OR IMMUNOLOGICAL ILLNESSES

VERFAHREN ZUR HERSTELLUNG VON NEUEN VER- AETHERTEN CYCLOPENTAN-1-AMINEN SOWIE DEREN SALZEN

POLYCYCLIC AROMATIC RING CLEAVAGE (PARC) PROCESS

ABSTRACT A process for the processing or upgrading of heavy oil fractions containing polynuclear aromatics is disclosed. The process comprises selectively oxidizing a feedstock under low severity conditions in a multi-phase system, wherein one phase is an aqueous and contains water-soluble catalyst, deoxygenating that product followed by hydroprocessing to yield a substantially mononuclear product. pat2.qtd

CYCLOALIPHATIC COMPOUNDS AS ODOUR AND TASTEMODIFYING AGENTS

DIBENZOCYCLOHEPTENES

Organophotoreceptor with a charge transport material having two epoxidated-hydrazone groups, a method for preparing the same and a method for using the same

Novel crosslinker unit for use in reversibly crosslinking polymer systems

The invention relates to a novel crosslinker unit for use in Diels-Alder crosslinking systems for reversibly crosslinking polymer systems, wherein this system in the present case may consist of just one component for the first time.

2-phenoxy- and 2-phenylsulfonamide derivatives with CCR3 antagonistic activity for the treatment of inflammatory or immunological disorders

Provided herein are 2-phenoxy- and 2-phenylsulfonamide derivatives with CCR3 antagonistic activity. These compounds are useful for the treatment of diseases associated with CCR3 activity, including but not limited to, atopic dermatitis, allergic rhinitis, rheumatoid arthritis, Grave's disease, HIV infection, Alzheimer's disease, atherosclerosis and other inflammatory and/or immunological disorders.

Halogenated amino methyl adamantane derivatives

Novel 2-substituted-1-methylamino adamantanes of formula: where X is hydroxyl or halogeno, and R1, R2 and R3 are hydrogen or C1-4 alkyl or R2 and R3 together with the nitrogen form a heterocyclic ring, having anti-Parkinsonian activity, pharmaceutical formulations containing the active adamantanes and novel 4-protoadamantane spiro oxirane and 1,2-difunctionalized intermediates useful in the preparation of the final products of the invention.

Flourene Derivative

This invention relates to a novel fluorene derivative having a characteristic structure in which guanidino group or the like functional group is linked to the fluorene structure via carbonyl group, or a salt thereof. The compound of the invention has an advantage in that it has high affinity for serotonin receptor subtypes, particularly for 5-HT_2B receptor and 5-HT₇ receptor, and shows excellent pharmacological effects in comparison with the conventional compounds which have only one of the antagonistic activities of 5-HT_2B receptor and 5-HT₇ receptor, this is useful as a prophylactic antimigraine agent having high safety and excellent effect.

ПРОИЗВОДНЫЕ 2-ФЕНОКСИ И 2-ФЕНИЛСУЛЬФОНАМИДА С ССR3 АНТАГОНИСТИЧЕСКОЙ АКТИВНОСТЬЮ ДЛЯ ЛЕЧЕНИЯ АСТМЫ И ДРУГИХ ВОСПАЛИТЕЛЬНЫХ ИЛИ ИММУНОЛОГИЧЕСКИХ ЗАБОЛЕВАНИЙ

FIELD: chemistry. ^ SUBSTANCE: invention relates to novel derivatives of benzene sulphonamide of formula (I), tautomeric and stereoisomeric forms and physiologically acceptable salts thereof: where X is O, S; R1 is H, halogen; R2 is H, halogen; halogen; R3 is NO2, CN; R4 is: , ^ where R71 is H; R72 is H; Z1 is -[CH2]P-, where p = 2. ^ EFFECT: compounds have antagonistic activity towards CCR3, which enables for their use in making medicinal agents. ^ 13 cl, 1 tbl, 3 ex РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) 2 380 356 (13) C2 (51) МПК C07C C07D C07D C07D A61K A61K 311/37 (2006.01) 401/04 (2006.01) 241/04 (2006.01) 487/04 (2006.01) 31/18 (2006.01) 31/4965 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ, ПАТЕНТАМ И ТОВАРНЫМ ЗНАКАМ (12) ОПИСАНИЕ ИЗОБРЕТЕНИЯ К ПАТЕНТУ (21), (22) Заявка: 2005132616/04, 11.03.2004 (24) Дата начала отсчета срока действия патента: 11.03.2004 (43) Дата публикации заявки: 20.04.2006 (56) Список документов, цитированных в отчете о поиске: WO 03/022277 А1, 20.03.2003. JP 11243960, 14.09.1999. RU 2155760 C1, 10.09.2000. (85) Дата перевода заявки PCT на национальную фазу: 24.10.2005 (73) Патентообладатель(и): АКТИМИС ФАРМАСЬЮТИКАЛЗ, ИНК. (US) 2 3 8 0 3 5 6 R U (87) Публикация PCT: WO 2004/084898 (07.10.2004) C 2 C 2 (86) Заявка PCT: EP 2004/002496 (11.03.2004) Адрес для переписки: 129090, Москва, ул. Б.Спасская, 25, стр.3, ООО "Юридическая фирма Городисский и Партнеры", пат.пов. Е.Е.Назиной (54) ПРОИЗВОДНЫЕ 2-ФЕНОКСИ И 2-ФЕНИЛСУЛЬФОНАМИДА С ССR3 АНТАГОНИСТИЧЕСКОЙ АКТИВНОСТЬЮ ДЛЯ ЛЕЧЕНИЯ АСТМЫ И ДРУГИХ ВОСПАЛИТЕЛЬНЫХ ИЛИ ИММУНОЛОГИЧЕСКИХ ЗАБОЛЕВАНИЙ (57) Реферат: Изобретение относится к новым производным бензолсульфонамида формулы (I), его таутомерным, стереоизомерным формам, его физиологически приемлемым солям: где Х означает О, S; R 1 означает Н, Ñòð.: 1 ru 2 3 8 0 3 5 6 (45) Опубликовано: 27.01.2010 Бюл. № 3 R U (30) Конвенционный приоритет: 24.03.2003 EP 03006293.9 (72) Автор(ы): ЛИ Инфу (JP), БЭЙКОН Кевин (JP), СУГИМОТО Хироми (JP), ...

Process

Cyclopentaindene fragrance ingredients

... 3a,6,9-Trimethyl-2,3,3a,4,5,7,8,9-octahydro-1H-cyclopenta[c]indene and derivatives thereof, in particular 5a,6-epoxy-3a,6,9-trimethyl-2,3,3a,4,5,7,8,9-octahydro-1H-cyclopenta[c]indene, are useful as fragrance ingredients having woody, ambery notes.

DIBENZOCYCLOHEPTENE DERIVATIVES

... 1311005 Dibenzocycloheptene derivatives SANDOZ Ltd 23 March 1970 [4 April 1969] 37785/72 Divided out of 1311004 Heading C2C Novel compounds I: (in which Z is -CH=CH- or -CH 2 -CH 2 -) are prepared by reacting a compound II: (in which R1 is C 1-4 alkyl) with hydrazine and subjecting the resulting carbohydrazide of Formula III: to rearrangement and cyclization in an acidic medium using a metal nitrite. Compounds II in which Z is -CH = CH- are prepared from the corresponding dibenzocyclohepten-5-one by the Reformatsky reaction.

TRICYCLIC HYDROCARBON AND PROCESS FOR PRODUCING THE SAME

ABSTRACT OF THE DISCLOSURE 5,6-Epoxy-1,2,6-trimethyltricyclo[5,3,2,02,7]dodecane having the formula (I)

DIBENZOCYCLOHEPTENES

epoxy-derivatives of cyclopentanonaphtalene and their method of preparation

Antiviral spiro tricyclo undecanes

METHODS OF TREATING AN OVERWEIGHT OR OBESE SUBJECT

Process for Preparing Terpinene-4-ol

The present invention relates to a process for preparing terpinene-4-ol from limonene-4-ol via a hydrogenation reaction in the presence of a nickel catalyst.

CYCLOALIPHATISCHE VERBINDUNGEN

CYCLOALIPHATIC COMPOUNDS AS ODOUR AND TASTEMODIFYING AGENTS

... 1363814 Cycloaliphatic compounds FIRMENICH SA 11 Oct 1972 [11 Oct 1971 19 May 1972] 46847/72 Heading C2C [Also in Divisions A5 A2 and C5] The invention comprises compounds of the formula where Z is a radical of the formula or and X is a radical of the formula -CH 2 -, or where R is hydrogen or C 1 -C 6 alkyl and R1 is hydrogen or acyl. The compounds may be prepared by (a) treating isoprene with a compound of the formula (b) epoxidizing a compound of the formula wherein the dotted lines show that the methyl group is either at position 4 or position 5, (c) catalytically hydrogenating the ethylenic bond in a compound of the formula (d) reducing the keto group of the compound of formula Ibh or of the saturated ketone derived therefrom to yield alcohols which may subsequently be esterified, (e) epoxidizing 5-methyl, tricyclo-[6.2.1.02,7]-undec-4-ene to yield an epoxide which may subsequently be treated with an acidic or basic agent to give 5-methyl-4-oxotricyclo-[6.2.1.0 ...

C14-HYDROXYL ESTERIFIED AMINO ACID DERIVATIVES OF TRIPTOLIDE, AND PREPARATION METHOD AND USE THEREOF

The present invention belongs to the field of natural pharmaceuticals and pharmaceutical chemistry, and relates to novel esterified amino acid derivatives of triptolide of general formulae I and II or a pharmaceutically acceptable adduct, complex, salt and catabolites and metabolites thereof, and a method for preparing these compounds, a pharmaceutical composition containing the compound, and a use thereof in the preparation of drugs for against tumours, immunological diseases, or diseases associated with abnormal expressions of XPB or Pol II or oncogene c-myc.

TRICYCLOUNDECANE DERIVATIVES

Methods of Treating an Overweight or Obese Subject

The disclosure herein generally relates to methods of treating an overweight or obese condition, and overweight- or obesity-related conditions. In one embodiment, the disclosure provides a method of treating an overweight or obese condition involving administering to the subject in need thereof, an amount of a pharmaceutical composition including a MetAP-2 inhibitory compound, or a salt, ester, or prodrug thereof, effective to result in weight loss in the subject. 3. The method of claim 1 , wherein the subject has a Body Mass Index measurement selected from the group consisting of: at least about 25 kg/m claim 1 , at least about 30 kg/m claim 1 , and at least about 40 kg/m.412.-. (canceled)14. (canceled) This application is a continuation of U.S. Ser. No. 14/802,473, filed Jul. 17, 2015, which is a continuation of U.S. Ser. No. 14/616,002, filed Feb. 6, 2015, which is a continuation of U.S. Ser. No. 13/133,062, filed Sep. 22, 2011, (now abandoned) which is a national phase filing under 35 U.S.C. §371 of PCT/US2009/066809, filed Dec. 4, 2009, which claims priority to U.S. provisional applications U.S. Ser. No. 61/119,875 filed Dec. 4, 2008, U.S. Ser. No. 61/119,881 filed Dec. 4, 2008, U.S. Ser. No. 61/119,884 filed Dec. 4, 2008, U.S. Ser. No. 61/119,886 filed Dec. 4, 2008, U.S. Ser. No. 61/275,688 filed Aug. 3, 2009, and U.S. Ser. No. 61/260,194 filed Nov. 11, 2009, each application of which is hereby incorporated by reference in its entirety.Obesity is a complex medical disorder of appetite regulation and metabolism resulting in excessive accumulation of adipose tissue mass. Typically defined as a body mass index (BMI) of 30 kg/mor more, obesity is a world-wide public health concern that is associated with cardiovascular disease, diabetes, certain cancers, respiratory complications, osteoarthritis, gallbladder disease, decreased life expectancy, and work disability. The primary goals of obesity therapy are to reduce excess body weight, improve or prevent obesity- ...

2-phenoxy- and 2-phenylsulfanyl-benzenesulfonamide derivatives with ccr3 antagonistic activity for the treatment of asthma and other inflammatory or immunological disorders

The present invention relates to a benzenesulfonamide derivative of formula (I), which is useful as an active ingredient of pharmaceutical preparations. The benzenesulfonamide derivatives of the present invention have CCR3 (CC type chemokine receptor) antagonistic activity, and can be used for the prophylaxis and treatment of disease associated with CCR3 activity, in particular for the treatment of asthma, atopic dermatitis, allergic rhinitis and other inflammatory/immunological disorders. wherein X represents O or S; R4 represents the other substituents are as defined in claim 1.

Polycyclic aromatic ring cleavage method

Process for preparing terpinene-4-ol

The present invention relates to a process for preparing terpinene-4-ol from limonene-4-ol via a hydrogenation reaction in the presence of a nickel catalyst.

PROCESS FOR OXIDATION OF OLEFINICALLY-UNSATURATED COMPOUNDS

TRICYCLOUNDECANE DERIVATIVES

TRICYCLIC HYDROCARBONS AND PRODUCTION THEREOF

2-Phenoxy- and 2-phenylsulfomamide derivatives with ccr3 antagonistic activity for the treatment of asthma and other inflammatory or immunological disorders

The present invention relates to a benzenesulfonamide derivative of formula (I), which is useful as an active ingredient of pharmaceutical preparations. The benzenesulfonamide derivatives of the present invention have CCR3 (CC type chemokine receptor) antagonistic activity, and can be used for the prophylaxis and treatment of diseases associated with CCR3 activity, in particular for the treatment of asthma, atopic dermatitis, allergic rhinitis and other inflammatory/immunological disorders. In said formula, X represents O or S; R4 represents formulae (a), (b), (c), (d), (e), (f), (g), (h), (i) or (j), the other substituents are as defined in claim 1.

Verfahren zur Epoxydierung olefinisch ungesaettigter Verbindungen

5,6-EPOXY-1,2,6-TRIMETHYLTRICYCLO ECKIGE KLAMMER AUF 5,3,2,0 HOCH 2,7 ECKIGE KLAMMER ZU DODECAN, VERFAHREN ZU SEINER HERSTELLUNG UND SEINE VERWENDUNG ALS RIECHSTOFF

ADAMANTANE DERIVATIVES

... 1507671 2 - Halo - 1 - aminomethyl - adamantanes LILLY INDUSTRIES Ltd 4 April 1975 [2 March 1974 (2)] 9521/74 and 9576/74 Heading C2C Novel 2 - halo - 1 - aminomethyl - adamanwherein X is a halogen atom, R1 is a hydrogen atom or C 1-4 alkyl gtoup and each of R2 and R3 is a hydrogen atom or C 1-4 alkyl group or NR2R3 is a mononuclear heterocyclic ring having 4-6 carbon atoms and not more than 2 heteroatoms, the ring being optionally substituted by phenyl or C 1-4 alkyl, and acid addition salts thereof, are prepared by reacting a 4- aminomethyl-protoadamantane-4-ol of the general formula with HX and optionally N-alkylating a product in which at least one of R2 and R3 is a hydrogen atom, followed optionally by salification. 4 - Aminomethyl - protoadamantane - 4 - ols of the second general formula above and acid addition salts thereof are prepared by reacting an oxirane of the general formula with R2R3NH, followed ...

New cyclopentano-naphthalene derivatives and their formation

The invention comprises 1-acyloxy-6-keto-7-(g - keto - butyl)-7,7a-epoxy-9a-methyl-3a,3b,4,5,8,9 - hexahydro-cyclopentano-[2,1-c]-naphthalenes of the general formula in which -OAc represents an acyloxy radical derived from an aliphatic, araliphatic or aromatic carboxylic acid and a process for the preparation thereof which comprises reacting a 1-acyloxy-6-keto-7-(g -keto-butyl)-9a-methyl-3a,3b,4,5,8,9 - hexahydro-cyclopentano-[2,1-c]-naphthalene with a per acid as oxidizing agent so as to introduce an epoxy configuration and thus to form the corresponding 1-acyloxy-6-keto-7-(g -keto-butyl)-7,7a-epoxy - 9a - methyl-3a,3b,4,5,8,9 - hexahydro-cyclopentano-[2,1-c]-naphthalene, the acyloxy radical being as defined above. The 1-acyloxy-6-keto-7-(g -keto-butyl) - 9a - methyl - 3a,3b,4,5,8,9-hexahydro-cyclopentano-[2,1-c]-naphthalene employed as starting material may be formed by condensing the corresponding 1-acyloxy-6-keto-9a-methyl - 3a,4,5,7,8,9 - hexahydro-cyclopentano ...

C14-hydroxyl esterified amino acid derivatives of triptolide, and preparation method and use thereof

The present invention belongs to the field of natural pharmaceuticals and pharmaceutical chemistry, and relates to novel esterified amino acid derivatives of triptolide of general formulae I and II or a pharmaceutically acceptable adduct, complex, salt and catabolites and metabolites thereof, and a method for preparing these compounds, a pharmaceutical composition containing the compound, and a use thereof in the preparation of drugs for against tumours, immunological diseases, or diseases associated with abnormal expressions of XPB or Pol II or oncogene c-myc.

EPOXIDES

METHOD FOR MANUFACTURING DIEPOXIDE COMPOUND

The present invention provides a method for manufacturing a diepoxide compound. The method for manufacturing a diepoxide compound of the present invention comprises a step for epoxidizing enzyme catalysts, hydrogen peroxide and diolefin compound under the presence of a buffer to manufacture the diepoxide compound. The method for manufacturing a diepoxide compound of the present invention is safe and environment-friendly since no hydrogen peroxide, alkyl peroxide and metal catalyst are used. COPYRIGHT KIPO 2018 ...

NEW ANTIVIRAL AGENTS

PROCESS FOR THE PREPARATION OF NEW TRICYCLE 4 4 1 1 3 8 UNDECANO 4 AMINO SUBSTITUIDAS AND YOU LEAVE THE SAME ONES

Method for producing epoxy compound

To provide a method for producing an epoxy compound at a high yield by means of hydrogen peroxide while suppressing the generation of by-products, wherein an organic compound having a carbon-carbon double bond is used as a raw material. The present invention provides a method for producing an epoxy compound, the method comprising a step for subjecting an organic compound having a carbon-carbon double bond to hydrogen peroxide in the presence of a catalyst to oxidize the carbon-carbon double bond, wherein the catalyst contains: a tungsten compound; a phosphoric acid, a phosphonic acid, or salts thereof; and an onium salt having alkyl sulfate ions as anions and represented by formula (I) [in the formula, R1 is a C1-18 linear or branched aliphatic hydrocarbon group which may be substituted by 1 to 3 phenyl groups].

EPOXIDES OF TRICYCLIC OLEFINIC C15H24 HYDROCARBONS

5,6-EPOXY-1,2,6-TRIMETHYLTRICYCLO ECKIGE KLAMMER AUF 5,3,2,0 HOCH 2,7 ECKIGE KLAMMER ZU DODECAN, VERFAHREN ZU SEINER HERSTELLUNG UND SEINE VERWENDUNG ALS RIECHSTOFF

VERFAHREN ZUR HERSTELLUNG VON ALLYLHYDROXYLIERTEN TERPENOIDEN KOHLENWASSERSTOFFEN

EPOXIDE OF A TRICYCLIC HYDROCARBON AND THE PREPARATION THEREOF

... 1453912 Perfumes TAKASAGO PERFUMERY CO Ltd 24 Dec 1974 [11 Jan 1974] 55826/ 74 Heading A5B [Also in Division C2] Perfume compositions contain a compound of the formula ...

OXIDATION OF OLEFINICALLY-UNSATURATED COMPOUNDS

NOVEL ANTIVIRAL AGENTS

2-PHENOXY- AND 2-PHENYLSULFOMAMIDE DERIVATIVES WITH CCR3 ANTAGONISTIC ACTIVITY FOR THE TREATMENT OF ASTHMA AND OTHER INFLAMMATORY OR IMMUNOLOGICAL DISORDERS

The present invention relates to a benzenesulfonamide derivative of formula (I), which is useful as an active ingredient of pharmaceutical preparations. The benzenesulfonamide derivatives of the present invention have CCR3 (CC type chemokine receptor) antagonistic activity, and can be used for the prophylaxis and treatment of diseases associated with CCR3 activity, in particular for the treatment of asthma, atopic dermatitis, allergic rhinitis and other inflammatory/immunological disorders. In said formula, X represents O or S; R4 represents formulae (a), (b), (c), (d), (e), (f), (g), (h), (i) or (j), the other substituents are as defined in claim 1.

BENZENESULFONAMIDE DERIVATIVES

The present invention relates to a benzenesulfonamide derivative of formula (I), which is useful as an active ingredient of pharmaceutical preparations. The benzenesulfonamide derivatives of the present invention have CCR3 (CC type chemokine receptor) antagonistic activity, and can be used for the prophylaxis and treatment of diseases associated with CCR3 activity, in particular for the treatment of asthma, atopic dermatitis, allergic rhinitis and other inflammatory/immunological disorders. In said formula, X represents O or S; R4 represents formulae (a), (b), (c), (d), (e), (f), (g), (h), (i) or (j), the other substituents are as defined in claim 1.

FLUORENE DERIVATIVE

A novel fluorene characterized by having a fluorene skeleton to which a functional group such as a guanidino group is attached via a carbonyl group, or its salt. This compound has such an advantage as showing a high affinity particularly for 5-HT2B receptor and 5-HT7 receptor, among serotonin receptor subtypes, and exhibiting an excellent pharmacological effect compared with a conventional compound having an antagonistic activity to only one of the 5-HT2B receptor and 5-HT7 receptor. Thus, it is useful as a highly efficacious and safe preventive for migraine.

EPOXIDES

TRIAZOLE AND IMIDAZOLE COMPOUNDS

Novel 3.2.1-bicyclo-octane compounds

The present invention relates to novel compounds and their use in fragrance compositions. Novel 3.2.1-bicyclo-octane compounds of the present invention are represented by formula: wherein R is selected from the group consisting of carbonyl and [1,3]dioxolane; R′ is selected from the group consisting of hydrogen and allyl; or R and R′ taken together represent

Process

The present invention provides a continuous process for the epoxidation of an olefinic compound with an oxidant, which process comprises reaction of an olefinic compound with an oxidant in the presence of a catalyst in an apparatus that comprises a reactive distillation column, which column comprises (i) a reactive section, which comprises the catalyst (ii) a rectifying section situated above the reactive section and adapted to allow separation of reagents and/or by-products from products (ix) a stripping section situated below the reactive section and adapted to allow separation of product from reagents and/or by-products (x) a vessel situated below the stripping section and adapted to provide a source of heat for the column and in which initial vaporisation of one or more of the reagents can occur, wherein the temperature in the reactive section (i) is a temperature at which the reaction between the olefinic compound and the oxidant takes place and the temperature in the stripping section (iii) is higher than the temperature in the rectifying section (ii).

Commands and method of treating cancer via RHO pathway

Lanosterol derivatives useful as anti-cancer agent, which can inhibit the growth of lung cancer cells, liver cancer cells, mammary cancer cells, brain cancer cells and pancreatic cancer cells, possibly by acting on the RHO pathway. These lanosterol derivatives are represented by compound LD030:

EPOXIDATION PROCESS

A method for producing ethylene oxide comprising: a) providing one or more feed components, wherein the one or more feed components contains at least ethylene obtained by dehydrating ethanol; b) contacting the one or more feed components with an ethylene oxide catalyst bed disposed in a reactor tube, the ethylene oxide catalyst bed comprising: (1) an upstream ethylene oxide catalyst having a first cesium concentration and (2) a downstream ethylene oxide catalyst having a second cesium concentration, wherein the first cesium concentration is higher than the second cesium concentration. 1. A method for producing ethylene oxide comprising:a) providing one or more feed components, wherein the one or more feed components contain at least ethylene;b) contacting the one or more feed components with an ethylene oxide catalyst bed disposed in a reactor tube, the ethylene oxide catalyst bed comprising: (1) an upstream ethylene oxide catalyst having a first cesium concentration and (2) a downstream ethylene oxide catalyst having a second cesium concentration, wherein the first cesium concentration is higher than the second cesium concentration.2. The method of claim 1 , wherein the ethylene is obtained by dehydrating ethanol.3. The method of claim 1 , wherein the ethylene is obtained from petroleum sources.4. The method of claim 1 , wherein the ethylene oxide catalyst bed comprises from about 10 wt % to about 90 wt % of the upstream ethylene oxide catalyst and about 10 wt % to about 90 wt % of the downstream epoxidation catalyst.5. The method of claim 1 , wherein the first cesium concentration is from about 200 ppm to about 1000 ppm and the second cesium concentration is from about 100 ppm to about 700 ppm.6. The method according to claim 1 , wherein the one or more feed components further comprises oxygen and a ballast gas.7. A system for producing ethylene oxide comprising:(a) a source of ethylene;(b) an ethylene oxide reactor containing a plurality of reactor tubes; and(c) ...

C14-HYDROXYL ESTERIFIED AMINO ACID DERIVATIVE OF TRIPTOLIDE, AND PREPARATION METHOD AND USE THEREOF

The present invention belongs to the field of natural medicines and medicinal chemistry, and relates to novel esterified amino acid derivatives of triptolide of general formula I and general formula II or pharmaceutically acceptable adducts, complexes, salts, and catabolites and metabolites thereof, preparation methods of these compounds, pharmaceutical compositions comprising the compound, and uses thereof in preparing drugs against tumors, immune diseases, or diseases related to abnormal expression of XPB or Pol II or oncogene c-myc. 2. A pharmaceutically acceptable adduct or complex of the C14-hydroxyl esterified amino acid derivative of triptolide according to .3. A pharmaceutically acceptable salt of the C14-hydroxyl esterified amino acid derivative of triptolide according to .4. A catabolite and a metabolite of the C14-hydroxyl esterified amino acid derivative of triptolide according to .5. A pharmaceutically acceptable adduct claim 1 , complex claim 1 , salt claim 1 , and catabolite and metabolite of the C14-hydroxyl esterified amino acid derivative of triptolide according to claim 1 , wherein Rand Rare selected from substituted or unsubstituted C-Calkyl claim 1 , substituted or unsubstituted C-Calkenyl claim 1 , substituted or unsubstituted C-Cconjugated alkenyl claim 1 , substituted or unsubstituted C-Ccycloalkyl or cycloalkenyl claim 1 , substituted or unsubstituted aryl claim 1 , substituted or unsubstituted heterocyclyl and aromatic heterocyclyl claim 1 , and substituted or unsubstituted amino acid side-chain alkyl claim 1 , the amino acid may be racemic claim 1 , or may be optically pure levorotary or dextrorotary; the substituents are selected from halogen claim 1 , amino claim 1 , C-Csubstituted amino claim 1 , nitro claim 1 , cyano claim 1 , hydroxyl claim 1 , C-Calkoxy claim 1 , mercapto claim 1 , and C-Calkylthio; Rand R claim 1 , Rand Rare or are not protecting groups; Rand Rare the same or different; Rand Rare the same or different; wherein R ...

Limonene-based (meth)acrylates for use in 3d printing

The present invention relates to photocurable compositions, comprising a limonene-based (meth)acrylate (A) obtainable by reacting a) 1 equivalent of a compound of formula, especially (I) with 1 to 3 equivalents of a compound of formula (II) in the presence of a catalyst and an inhibitor at elevated temperature and its use in a photopolymerization 3D printing process. The limonene-based (meth)acrylate (A) significantly increases stiffness and glass transition temperatures of photo-cured acrylate compositions. While such effects are usually achieved with the use of aromatic or bisphenol A based compounds, the limonene-based (meth)acrylate (A) offers a sustainable alternative at much lower viscosity.

EPOXY COMPOUND, CURABLE COMPOSITION, CURED PRODUCT, METHOD OF PRODUCING EPOXY COMPOUND, AND REACTIVE DILUENT

The present invention discloses a monoepoxy compound represented by the following Formula (1), a curable composition containing the same, a cured product therefrom, a method of producing the monoepoxy compound, and a reactive diluent containing the monoepoxy compound. The monoepoxy compound represented by the Formula (1) is useful in that it is capable of reducing the viscosity of a curable composition containing the monoepoxy compound, while preventing a reduction in the heat resistance of the curable composition as well as a reduction in the weight of the curable composition upon curing. 2. The monoepoxy compound according to claim 1 , comprising a stereoisomer(s) of the compound represented by the Formula (1) claim 1 , wherein the ratio claim 1 , as measured by C-NMR analysis claim 1 , of a peak area(s) derived from a stereoisomer(s) in which the bridgehead of the norbornane skeleton and the vinyl group in the Formula (1) are in a trans relationship claim 1 , to the total peak area within the chemical shift range of from 140 to 145 ppm claim 1 , is 66% or more.4. The monoepoxy compound according to claim 1 , wherein claim 1 , in the C-NMR analysis of the compound represented by the Formula (1) claim 1 , the ratio of the total peak area within the chemical shift range of from 140 to 142 ppm to the total peak area within the chemical shift range of from 140 to 145 ppm is 66% or more.5. The monoepoxy compound according to claim 2 , wherein claim 2 , in the C-NMR analysis of the compound represented by the Formula (1) claim 2 , the ratio of the area of the first peak from the low magnetic field side claim 2 , among peaks within the chemical shift range of from 140 to 142 ppm claim 2 , to the total peak area within the chemical shift range of from 140 to 145 ppm is 35% or more.6. A curable composition comprising:{'claim-ref': {'@idref': 'CLM-00001', 'claim 1'}, 'the monoepoxy compound according to ; and'}one kind selected from the group consisting of a curing agent, a ...

NEUROACTIVE SUBSTITUTED CYCLOPENTA[b]PHENANTHRENES AS MODULATORS FOR GABA TYPE-A RECEPTORS

The present disclosure is generally directed to neuroactive substituted cyclopenta[b]phenanthrenes as referenced herein, and pharmaceutically acceptable salts thereof, for use as, for example, an anesthetic, and/or in the treatment of disorders relating to GABA function and activity. The present disclosure is further directed to pharmaceutical compositions comprising such compounds.

NOVEL SPIROSESQUITERPENE COMPOUND, FLAVORING COMPOSITION AND FOOD/DRINK CONTAINING SAID COMPOUND, AND METHOD FOR PRODUCING SAID FOOD/DRINK

The present invention pertains to a compound represented by formula (1) with which it is possible to impart or enhance an aroma and flavor associated with the feeling of a highly natural fruit or fruit juice, or ripeness. The present invention also pertains to a flavoring composition containing said compound, a food/drink containing said compound or said flavoring composition, and a method for producing said food/drink. 2. A flavor composition containing the compound according to .3. The flavor composition according to claim 2 , which is a flavor composition having a fruit-like aroma.4. The flavor composition according to claim 3 , wherein the fruit-like aroma is a citrus fruit aroma.5. The flavor composition according to claim 4 , wherein the citrus fruit is at least one selected from the group consisting of grapefruit claim 4 , orange and lemon.6. The flavor composition according to claim 2 , which is a flavor composition for a food/beverage.7. The flavor composition according to claim 6 , wherein the food/beverage is a beverage.8. The flavor composition according to claim 7 , wherein the beverage is a citrus beverage.9. A food/beverage containing the compound according to .10. A food/beverage containing the flavor composition according .11. A method for producing a food/beverage claim 1 , comprising adding the compound according to .12. A method for producing a food/beverage claim 2 , comprising adding the flavor composition according to . The present invention is related to a novel spirosesquiterpene compound, a flavor composition and a food/beverage each containing the compound, and a method for producing the food/beverage. More specifically, the present invention is related to an epoxyspirolepechinene having a woody aroma, a flavor composition and a food/beverage each containing the epoxyspirolepechinene as an effective ingredient, and a method for producing the food/beverage.In recent years, along with a diversification in consumer needs for foods or ...

SYNERGISTIC ANTICOAGULANT COMPOSITION

A composition is provided that, when utilized in combination with a coumarin anticoagulant, greatly improves the anticoagulant effects of the anticoagulant in mammalian subjects. The composition is a compound having a naphthohydroquinone ring system substantially similar to the ring system of the reduced form of vitamin Kand has the general formula: 9. The composition in claim 5 , wherein the anticoagulant is a coumarin-based anticoagulant.10. The composition in claim 6 , wherein the anticoagulant is a coumarin-based anticoagulant.11. The composition in claim 7 , wherein the anticoagulant is a coumarin-based anticoagulant.12. The composition in claim 8 , wherein the anticoagulant is a coumarin-based anticoagulant.13. The composition in claim 5 , wherein the anticoagulant is warfarin.14. The composition in claim 6 , wherein the anticoagulant is warfarin.15. The composition in claim 7 , wherein the anticoagulant is warfarin.16. The composition in claim 8 , wherein the anticoagulant is warfarin.17. The composition in claim 5 , wherein the anticoagulant is a second-generation coumarin anticoagulant.18. The composition in claim 6 , wherein the anticoagulant is a second-generation coumarin anticoagulant.19. The composition in claim 7 , wherein the anticoagulant is a second-generation coumarin anticoagulant.20. The composition in claim 8 , wherein the anticoagulant is a second-generation coumarin anticoagulant.21. The composition in claim 8 , wherein the adjuvant composition is obtained by hydrolysis of the composition in and wherein the anticoagulant is a coumarin-based anticoagulant.22. The composition in claim 8 , wherein the adjuvant composition is obtained by hydrolysis of the composition in and wherein the anticoagulant is a coumarin-based anticoagulant.23. The composition in claim 8 , wherein the adjuvant composition is obtained by hydrolysis of the composition in and wherein the anticoagulant is warfarin.24. The composition in claim 8 , wherein the adjuvant ...

EPOXY COMPOUND, RESIST COMPOSITION, AND PATTERN FORMING PROCESS

An epoxy compound of formula (1) is provided. A resist composition comprising the epoxy compound is capable of adequately controlling the diffusion length of acid generated from an acid generator without sacrificing sensitivity. 5. A pattern forming process comprising the steps of applying the resist composition of to form a resist film on a substrate claim 2 , exposing the resist film to high-energy radiation claim 2 , and developing the exposed resist film in a developer.6. The process of wherein an alkaline aqueous solution is used as the developer in the developing step to form a positive pattern wherein the exposed region of film is dissolved and the unexposed region of film is not dissolved.7. The process of wherein an organic solvent is used as the developer in the developing step to form a negative pattern wherein the unexposed region of film is dissolved and the exposed region of film is not dissolved. This non-provisional application claims priority under 35 U.S.C. § 119(a) on Patent Application No. 2019-040260 filed in Japan on Mar. 6, 2019, the entire contents of which are hereby incorporated by reference.This invention relates to an epoxy compound, a resist composition comprising the same, and a pattern forming process using the resist composition.To meet the demand for higher integration density and operating speed of LSIs, the effort to reduce the pattern rule is in rapid progress. As the advanced micropatterning technology, the ArF immersion lithography involving exposure through a liquid (typically water) held between a projection lens and a substrate is implemented in a mass scale. Besides, studies are being made on the multi-patterning of ArF lithography and the lithography using extreme ultraviolet (EUV) of wavelength 13.5 m.The mainstream ArF lithography resist compositions are chemically amplified resist compositions comprising a base polymer and a photoacid generator as essential components. Upon light exposure, the acid generator generates an ...

Process for the Preparation of Chiral Epoxides

본 발명은 키랄 에폭사이드를 제조하는 방법에 관한 것으로서, 구체적으로 이온성 액체 용매에서 키랄 살렌금속촉매 존재하에 올레핀과 산화제를 반응시켜 비대칭 에폭시화 반응에 의해 키랄 에폭사이드를 제조하는 방법에 관한 것으로, 본 발명의 제조방법에 의하면 반응 후 고가의 키랄 살렌금속촉매의 회수를 용이하게 하여 반복적으로 사용할 수 있으므로 경제적으로 키랄 에폭사이드를 제조할 수 있다. The present invention relates to a method for preparing chiral epoxide, and more particularly, to a method for preparing chiral epoxide by an asymmetric epoxidation reaction by reacting an olefin and an oxidant in the presence of a chiral salen metal catalyst in an ionic liquid solvent. According to the production method of the present invention, it is easy to recover the expensive chiral salen metal catalyst after the reaction, and thus can be repeatedly used, thereby economically preparing chiral epoxides.

Proceso para preparar terpinen-4-ol

Un proceso para preparar terpinen-4-ol a partir de limonen-4-ol mediante una reacción de hidrogenación en presencia de un catalizador de níquel y de al menos un solvente orgánico. Reivindicación 8: El proceso de acuerdo con cualquiera de las reivindicaciones 1 a 7, caracterizado porque limonen-4-ol de la fórmula (1) se prepara mediante isomerización de terpinolen epóxido de la fórmula (2).

Epoxy compound, curable composition, cured product, method for preparing epoxy compound and reactive diluent

이하의 식(1)의 모노에폭시 화합물, 이것을 포함하여 이루어지는 경화성 조성물, 그 경화물, 그 모노에폭시 화합물의 제조 방법, 및 그 모노에폭시 화합물을 포함하여 이루어지는 반응 희석제가 개시된다. 식(1)의 모노에폭시 화합물은, 경화성 조성물에 함유시켰을 때, 경화성 조성물의 내열성의 저하 및 이 경화성 조성물을 경화시켰을 때의 중량 감소를 방지하면서, 경화성 조성물의 점도를 저하시킬 수 있는 점에서 유용하다. (식 중, R 1 내지 R 6 은 각각 독립하여, 수소, 알킬기 및 알콕시기로 이루어지는 군으로부터 선택된다.) A monoepoxy compound of the following formula (1), a curable composition comprising the same, a cured product thereof, a method for producing the monoepoxy compound, and a reaction diluent comprising the monoepoxy compound are disclosed. When the monoepoxy compound of formula (1) is contained in the curable composition, it is useful in that it can reduce the viscosity of the curable composition while preventing the decrease in heat resistance of the curable composition and weight loss when the curable composition is cured do. (Wherein, R 1 to R 6 are each independently selected from the group consisting of hydrogen, an alkyl group, and an alkoxy group.)

Functionalized matrixes for dispersion of nanostructures

本发明提供了用半导体纳米晶体掺杂的基质。在某些具体实施方案中，该半导体纳米晶体具有使得在特定波长下它们吸收或发射光的尺寸和组成。该纳米晶体可以包含允许用于与不同的基质材料混合的配体，包括聚合物，以至于最少部分的光被该基质散射。该基质任选由配体形成。本发明的基质还可以用于折射率的匹配应用。在其他的具体实施方案中，将半导体纳米晶体嵌入基质中以形成纳米晶体密度梯度，由此产生有效的折射率梯度。本发明的基质还可以用作光学器件上的滤波器和抗反射涂层并且用作下变频层。本发明还提供了用于制备包含半导体纳米晶体的基质的方法。本发明还描述了具有高量子效率、小尺寸、和/或窄的尺寸分布的纳米结构体、制备磷化铟纳米结构体和具有第II-VI族的壳的核-壳纳米结构体的方法。

Fluorene derivative

本发明涉及一种具有特征结构的新颖芴衍生物或其盐，该特征结构具有通过羰基连接到芴结构的胍基等官能团。本发明化合物的优点是对血清素受体亚型，特别是对5－HT 2B 受体和5－HT 7 受体具有高的亲和力，与只对5－HT 2B 受体和5－HT 7 受体之一具有拮抗活性的常规化合物相比显示优良的药理效果，这种化合物能用作高安全性并具有良好效果的抗偏头痛的预防剂。

Tricycloundecane derivatives

C14 hydroxyl esterified amino acid derivative of tryptride, and its production method and use

Novel crosslinker unit for use in reversibly crosslinking polymer systems

The invention relates to a novel crosslinker unit for use in Diels-Alder crosslinking systems for reversibly crosslinking polymer systems. According to the invention, said system can consist of a single component for the first time.

C14-hydroxyl esterified amino acid derivatives of triptolide, and methods for their preparation and uses

본 발명은 천연 제약 및 제약 화학의 분야에 속하고, 화학식 I 및 II의 트리프톨리드의 신규 에스테르화 아미노산 유도체 또는 그의 제약상 허용되는 부가물, 착물, 염 및 이화대사물 및 대사물, 이들 화합물의 제조 방법, 화합물을 함유하는 제약 조성물, 및 종양, 면역 질환, 또는 XPB 또는 Pol II 또는 종양유전자 c-myc의 비정상적 발현과 연관된 질환에 대한 약물을 제조하는 데 있어서의 그의 용도에 관한 것이다. The present invention belongs to the field of natural pharmaceuticals and pharmaceutical chemistry and includes novel esterified amino acid derivatives of triptolide of formulas I and II or pharmaceutically acceptable adducts, complexes, salts and catabolites and metabolites thereof, these compounds to a method for the preparation of, pharmaceutical compositions containing the compound, and its use in the manufacture of a medicament for tumors, immune diseases, or diseases associated with abnormal expression of XPB or Pol II or the oncogene c-myc.

Alicyclic epoxy (meth)acrylates, process for production thereof, and copolymers

본 발명은, 3,4-에폭시트리시클로[5.2.1.0 2,6 ]데칸 골격 및 중합성 불포화 결합을 갖는 신규 화합물 및 그의 제조 방법을 제공한다. 또한, (A) 알칼리 가용성기를 포함하는 단량체 단위 및 (B) 에폭시기 함유 중합성 불포화 화합물에 대응하는 단량체 단위를 포함하는 공중합체, 또는 상기 단량체 단위 (A) 및 (B) 뿐만 아니라 (C) N-치환 말레이미드 등의 에폭시기 비함유 중합성 불포화 화합물에 대응하는 단량체 단위를 포함하는 공중합체이며, 상기 단량체 단위 (B)의 비율이 전체 단량체 단위에 대하여 40 내지 90 중량％이고, 상기 단량체 단위 (B) 중 30 중량％ 이상이 특정한 3,4-에폭시트리시클로[5.2.1.0 2,6 ]데칸 골격 함유 화합물에 대응하는 단량체 단위인 것을 특징으로 한다. 상기 공중합체에 의해 내열성 등이 우수한 피막을 형성할 수 있음과 동시에, 상기 수지를 포함하는 수지 조성물의 보존 안정성이 매우 높으며, 상기 공중합체는 합성도 용이하다. 지환식 에폭시 불포화 카르복실산에스테르, 지환식 에폭시(메트)아크릴레이트 The present invention provides a novel compound having a 3,4-epoxytricyclo [5.2.1.0 2,6 ] decane skeleton and a polymerizable unsaturated bond and a method for producing the same. Moreover, the copolymer containing (A) the monomer unit containing an alkali-soluble group, and (B) the monomer unit corresponding to an epoxy group containing polymerizable unsaturated compound, or said monomer unit (A) and (B), as well as (C) N It is a copolymer containing the monomer unit corresponding to an epoxy-group-containing polymerizable unsaturated compound, such as substituted maleimide, The ratio of the said monomer unit (B) is 40-90 weight% with respect to all monomer units, The said monomer unit ( 30% by weight or more in B) is a monomer unit corresponding to the specific 3,4-epoxytricyclo [5.2.1.0 2,6 ] decane skeleton-containing compound. The copolymer can form a film having excellent heat resistance and the like, and also has a very high storage stability of the resin composition containing the resin, and the copolymer can be easily synthesized. Alicyclic epoxy unsaturated carboxylic ester, alicyclic epoxy (meth) acrylate

CYCLOPENTANE-1-AMINES, PROCESS FOR THEIR PREPARATION AND PRODUCTS CONTAINING THESE COMPOUNDS

L'invention concerne des composés chimiques nouveaux et leur préparation. L'invention concerne des cydopentane-1-amines de formule 1: The invention relates to novel chemical compounds and their preparation. The invention relates to cydopentane-1-amines of formula 1:

Patent FR2375187B1

Epoxidation process

A method for producing ethylene oxide comprising: a) providing one or more feed components, wherein the one or more feed components contains at least ethylene obtained by dehydrating ethanol; b) contacting the one or more feed components with an ethylene oxide catalyst bed disposed in a reactor tube, the ethylene oxide catalyst bed comprising: (1) an upstream ethylene oxide catalyst having a first cesium concentration and (2) a downstream ethylene oxide catalyst having a second cesium concentration, wherein the first cesium concentration is higher than the second cesium concentration.

Process for preparing terpinen-4-ols

本发明涉及一种通过在镍催化剂存在下氢化反应从苧烯‑4‑醇制备萜品烯‑4‑醇的方法。

Compound and application thereof in field of optoelectronics

Disclosed is a compound comprising at least one structural unit represented by formulas (1)-(4). The compound comprises at least one cross-linkable group. The compound has a relatively large molar extinction coefficient and high fluorescence luminous efficiency. A color conversion layer made of same can absorb incident light more effectively to facilitate the preparation of a relatively thin color conversion layer. In addition, an absorption spectrum of the compound can be adjusted by modifying the molecular structure thereof. Different types of color conversion layers can be prepared by using compounds of different chemical structures, light of different colors can be absorbed, and in cooperation with narrow half-peak width luminescent materials of different colors, display devices having high color gamut can be fabricated.

Epoxidation catalyst and preparation method thereof, epoxidation catalyst system and preparation method of epoxidation catalyst system

本发明涉及一种环氧化催化剂及其制备方法，一种环氧化催化剂体系及其制备方法。所述环氧化催化剂的结构式如下：

Derivatives of the a-neo-oleanane series

1,244,980. A-Neo-oleananes. BIOREX LABORATORIES Ltd. 25 Nov., 1969 [18 Dec., 1968], No. 60209/68. Heading C2U. The invention comprises compounds of formula wherein X is H or alkyl; and their preparation by oxidation of the corresponding compounds having an additional carbon-carbon bond in place of the epoxy group.

Epoxy compound, curable composition, cured product, method for producing epoxy compound, and reactive diluent

本發明揭示以下之式(1)之單環氧化合物、含有其而成之硬化性組合物、其硬化物、該單環氧化合物之製造方法、以及含有該單環氧化合物而成之反應稀釋劑。式(1)之單環氧化合物於在含有於硬化性組合物中時可防止硬化性組合物之耐熱性之降低及使該硬化性組合物硬化時之重量減少，並且降低硬化性組合物之黏度之方面較有用。□(式中，R1至R6分別獨立地選自由氫、烷基及烷氧基所組成之群中)

A manufacturing method of cycloaliphatic epoxy compound

지환식 에폭시 화합물의 제조방법에 관한 것으로, 일 양상에 따른 제조 방법은 OXONE을 이용하여 지환식 올레핀 화합물을 제조함에 따라 보다 효율적이고 안정적으로 고순도 및 고수율의 지환식 에폭시 화합물을 제조할 수 있다.

Epoxidation process

PROCEDURE FOR PREPARING THE TERPINEN-4 OL

Patent JPS6049619B2

Resin composition capable of polymerizing

一种可聚合树脂组合物，所述可聚合树脂组合物包含(A)树脂、(B)可聚合化合物、(C)引发剂、(C－1)引发助剂、(T)多官能硫醇化合物和(D)溶剂，其中所述引发助剂(C－1)包含式(V)的化合物，在式(V)中，X所示的点线表示芳族环，Y表示氧原子或硫原子，R 1 表示含1至6个碳原子的烷基，R 2 表示任选被卤原子取代的含1至12个碳原子的烷基或任选被卤原子取代的含6至12个碳原子的芳基。

The triptolide amino acid derivativges of C14 hydroxy esterifications, and its preparation method and application

本发明属于天然药物及药物化学领域并涉及通式I和通式II的新型雷公藤甲素的酯化氨基酸衍生物或其药学上可接受的加成物、复合物、盐、以及分解和代谢产物，制备这些化合物的方法、包含该化合物的药物组合物及其在制备抗肿瘤、免疫性疾病、XPB或Pol II或致癌基因c‑myc异常表达相关疾病药物中的用途。

Triazole and imidazole compounds, a process for preparing them, their use as plant fungicides and fungicidal compositions containing them

Compounds of the formula: having pesticidal (especially fungicidal) and plant growth regulating activity wherein R is a bridging group -(CH₂) n - where n is 0, 1 or 2, or a bridging group -CH=CH-, or is -O-, -S-, -NH-, or --; X is =N- or =CH-; Y and Z, which may be the same or different, are halogen, alkyl, alkoxy, halo-alkoxy, halo-alkyl, nitro, phenyl or phenoxy; m and p are 0, 1, 2 or 3; and salts, metal complexes and functional derivatives thereof.

process for producing caryophyllene oxide

A presente invenção se refere a um processo para a oxidação de beta-cariofileno com oxigênio, em particular oxigênio atmosférico, o qual dispensa o uso de catalisadores, enzimas e solventes. Além disso, a presente invenção provê uma mistura compreendendo determinados óxidos de cariofileno e seu uso como um aromatizante e/ou odorante. A presente invenção também se refere a produtos e produtos semiacabados compreendendo a mistura de acordo com a presente invenção. The present invention relates to a process for the oxidation of beta-caryophyllene with oxygen, in particular atmospheric oxygen, which eliminates the need for catalysts, enzymes and solvents. In addition, the present invention provides a mixture comprising certain caryophyllene oxides and their use as a flavoring and/or odorant. The present invention also relates to semi-finished products and products comprising the mixture according to present invention.

Asiatic acid derivatives and medicines for treating wounds, which contains the same

The present invention relates to asiatic acid derivatives represented by formula (1), and medicines for treating wounds, which contains the same as an active component.

Procedure for the preparation of a mixture of terpene alcohols

Un procedimiento para la preparación de una mezcla de alcoholes de terpeno que comprende limoneno-4-ol de la fórmula (II) **(Ver fórmula)** y terpineno-4-ol de la fórmula (III) **(Ver fórmula)** en el que dicho procedimiento comprende el contacto de epóxido de terpinoleno de la fórmula (I) **(Ver fórmula)** con hidrógeno en presencia de por lo menos un catalizador de cobre y por lo menos un solvente orgánico inerte seleccionado de ésteres de ácido carboxílico. A process for the preparation of a mixture of terpene alcohols comprising limonene-4-ol of formula (II) ** (See formula) ** and terpinene-4-ol of formula (III) ** (See formula ) ** wherein said process comprises the contact of terpinolene epoxide of formula (I) ** (See formula) ** with hydrogen in the presence of at least one copper catalyst and at least one selected inert organic solvent of carboxylic acid esters.

Process

The present invention provides a continuous process for the epoxidation of an olefinic compound with an oxidant, which process comprises reaction of an olefinic compound with an oxidant in the presence of a catalyst in an apparatus that comprises a reactive distillation column, which column comprises (i) a reactive section, which comprises the catalyst (ii) a rectifying section situated above the reactive section and adapted to allow separation of reagents and/or by-products from products (ix) a stripping section situated below the reactive section and adapted to allow separation of product from reagents and/or by-products (x) a vessel situated below the stripping section and adapted to provide a source of heat for the column and in which initial vaporisation of one or more of the reagents can occur, wherein the temperature in the reactive section (i) is a temperature at which the reaction between the olefinic compound and the oxidant takes place and the temperature in the stripping section (iii) is higher than the temperature in the rectifying section (ii).

Processes for functionalization and polymerization of polyaromatic feedstock

Processes for chemically treating polyaromatic feedstock to form aromatic-containing oligomers or polymers are provided. The processes are characterized by treatment of a plurality of different polyaromatic hydrocarbon molecules and/or polyheterocychc molecules present in polyaromatic feedstock with a first reagent so as to functionalize the molecules. Further treatment in a second step affords oligomeric or polymeric products which may be crosslinked. The products may be thermoplastic or thermoset materials and may find use in, for example, infrastructure applications, composites, fillers, fire retardants and 3-D printing materials.

The preparation method of diepoxide

本发明提供二环氧化物的制备方法，本发明的二环氧化物的制备方法包括在酶催化剂、过氧化氢及缓冲剂的存在下将二烯烃化合物进行环氧化来制备二环氧化物的步骤。

Epoxy compound, resist composition, and pattern formation method

本发明涉及环氧化合物、抗蚀剂组合物、及图案形成方法。本发明的课题为提供无损感度而能适当地控制产生自产酸剂的酸的扩散长度的抗蚀剂组合物、及使用了该抗蚀剂组合物的图案。该课题的解决方法为以下式(1)表示的环氧化合物、及含有该环氧化合物的抗蚀剂组合物。 式中，X 1 及X 2 分别独立地为‑CH 2 ‑或‑O‑。k A 为0或1。R 1 及R 2 分别独立地为碳数4～20的叔烃基、或选自于下式中的基团。

Patent JPS5335141B2

2-PHENOXY- AND 2-PHENYLSULFANYL-BENZENESULFONAMIDE DERIVATIVES WITH CCR3 ANTAGONISTIC ACTIVITY FOR THE TREATMENT OF ASTHMA AND OTHER FLAMMABLE OR IMMUNOLOGICAL DISEASES

Fluorene derivative

A novel fluorene characterized by having a fluorene skeleton to which a functional group such as a guanidino group is attached via a carbonyl group, or its salt. This compound has such an advantage as showing a high affinity particularly for 5-HT2B receptor and 5-HT7 receptor, among serotonin receptor subtypes, and exhibiting an excellent pharmacological effect compared with a conventional compound having an antagonistic activity to only one of the 5-HT2B receptor and 5-HT7 receptor. Thus, it is useful as a highly efficacious and safe preventive for migraine.

C14-hydroxyl esterified amino acid derivatives of triptolide, and preparation method and use thereof

Method for producing epoxy compound

The invention provides a method for producing an epoxy compound by hydrogen peroxide using an organic compound having a carbon-carbon double bond as a raw material, wherein a by-product is suppressed from being generated and the epoxy compound is produced in a high yield. In particular, the invention provides a method for producing an epoxy compound involving oxidizing a carbon-carbon double bond in an organic compound with hydrogen peroxide in the presence of a catalyst, wherein the catalyst comprises a tungsten compound; a phosphoric acid, a phosphonic acid or salts thereof; and an onium salt having an alkyl sulfate ion represented by formula (I) as an anion: wherein R 1 is a linear or branched aliphatic hydrocarbon group having 1 to 18 carbons, which may be substituted with 1 to 3 phenyl groups.

Process for producing ethylene carbonate and ethylene glycol

Limonene-based (meth)acrylates for use in 3d printing

The present invention relates to photocurable compositions, comprising a limonene-based (meth)acrylate (A) obtainable by reacting a) 1 equivalent of a compound of formula especially with 1 to 3 equivalents of a compound of formula in the presence of a catalyst and an inhibitor at elevated temperature and its use in a photopolymerization 3D printing process. The limonene-based (meth)acrylate (A) significantly increases stiffness and glass transition temperatures of photo-cured acrylate compositions. While such effects are usually achieved with the use of aromatic or bisphenol A based compounds, the limonene-based (meth)acrylate (A) offers a sustainable alternative at much lower viscosity.

Process for preparing terpinene-4-ol

The present invention relates to a process for preparing terpinene-4-ol from limonene-4-ol via a hydrogenation reaction in the presence of a nickel catalyst.

Patent JPS495958A

Cyclopentan-1-amines

Compounds of the Formula ##STR1## and the physiologically acceptable salts thereof, wherein R 1 and R 2 each is hydrogen or benzyl; R 3 is alkyl of 5-10 C-atoms or 2-hydroxyalkyl of 5-10 C-atoms; R 4 is hydrogen, methyl or ethyl; R 5 is alkyl of 5-10 C-atoms or --C n H 2n COOR 6 ; R 6 is hydrogen or alkyl of 1-4 C-atoms; and n is 0, 4, 5 or 6 are effective for inhibiting adhesion and/or agglomeration of thrombocytes.

Epoxide, solidification compound, solidfied material, the preparation method of epoxide and reactive diluent

本发明公开了以下的式(1)的单环氧化合物、含有该单环氧化合物的固化性组合物、其固化物、该单环氧化合物的制备方法、以及含有该单环氧化合物的反应稀释剂。式(1)的单环氧化合物在以下方面是有用的：包含在固化性组合物中时，能够防止：固化性组合物的耐热性降低以及使该固化性组合物固化时的重量减少，且能够降低固化性组合物粘度。式中，R 1 至R 6 各自独立地选自由氢、烷基以及烷氧基组成的组。

Method for manufacturing an epoxy compound and method for epoxidizing a carbon-carbon double bond

本发明提供环氧化合物的制造方法，其特征在于，对于具有碳-碳双键的有机化合物，在催化剂和中性无机盐的存在下，利用过氧化氢使该双键氧化，所述催化剂为钨化合物(a)、选自由磷酸类、膦酸类以及它们的盐组成的组中的至少一种磷化合物(b)和表面活性剂(c)的组合；并且提供环氧化方法，其特征在于，在上述催化剂和中性无机盐的存在下，利用过氧化氢使碳-碳双键氧化。

Methods for functionalization and polymerization of polyaromatic feedstocks

다환방향족 공급원료를 화학적으로 처리하여 방향족-함유 올리고머 또는 중합체를 형성하는 방법이 제공된다. 상기 방법은, 분자를 작용화하기 위해, 상기 다환방향족 공급원료에 존재하는 복수의 상이한 다환방향족 탄화수소 분자 및/또는 폴리헤테로환형 분자를 제1 시약으로 처리하는 것을 특징으로 한다. 제2 단계에서의 추가 처리는, 가교결합될 수 있는 올리고머성 또는 중합체성 생성물을 제공한다. 상기 생성물은 열가소성 또는 열경화성 물질일 수 있고, 예를 들어, 기반 시설 용도, 복합체, 충전제, 난연제 및 3D 인쇄 물질에 사용될 수 있다.

Tricyclic aliphatic cpds - for use as aroma agents

Tricyclic compounds and use thereof as perfume ingredients

New tricyclic compounds and use thereof as perfume ingredients. Perfume compositions and perfumed articles containing same.

Carnation alkene oxide

本发明涉及一种用氧，特别是大气氧来氧化β‑石竹烯的方法，该方法避免使用催化剂、酶和溶剂。此外，本发明提供一种包含某些石竹烯氧化物的混合物及其作为香料和/或香水的用途。本发明还涉及包含根据本发明的混合物的产品和半成品。

Patent JPS5530686B2

Cyclopentan-1-amines and the preparation thereof

Resin composition, cured product, laminate, method for producing cured product, semiconductor device, and compound

환화 수지 및 그 전구체로 이루어지는 군으로부터 선택되는 적어도 1종의 수지, 및, 연결기를 개재하여 서로 결합되어 있는 중합성기와 아마이드 결합을 갖는 중합성 화합물을 포함하고, 상기 아마이드 결합은 상기 연결기와 카보닐기 측에서 결합되어 있으며, 상기 중합성 화합물을 이용하여 단일 중합체를 합성한 경우, 상기 단일 중합체는 250℃의 가열에 의하여 주쇄로부터 유리되는 염기를 발생하는 성질을 나타내는 수지 조성물, 상기 수지 조성물을 경화하여 이루어지는 경화물, 상기 경화물을 포함하는 적층체, 상기 경화물의 제조 방법, 및, 상기 경화물 또는 상기 적층체를 포함하는 반도체 디바이스, 및, 신규 화합물.

A therapeutic agent for irritable bowel disease

Process for preparing terpene alcohol mixtures

本发明涉及一种通过在铜催化剂存在下异构化和/或氢化反应从萜品油烯环氧化物制备包含苧烯‑4‑醇和萜品烯‑4‑醇的萜烯醇混合物的方法。

Fluorenderivat

Fluoren hvor en funksjonell gruppe, så som guanidingruppe, er bundet via en karbonylgruppe til fluorenskjelettet, eller et salt av dette. Forbindelsen viser høy affinitet for 5-HT2B-reseptor og 5-HT7-reseptor blant serotoninreseptorundertypene, og viser utmerket farmakologisk virkning sammenlignet med en konvensjonell forbindelse som har antagonistisk aktivitet bare overfor én av 5-HT2B-reseptor og 5-HT7-reseptor. Forbindelsen er anvendelig som et effektivt og sikkert middel for forhindring av migrene.

Tricyclic hydrocarbon and process for producing the same

5,6-Epoxy-1,2,6-trimethyltricyclo[5,3,2,0 2 ,7 ]dodecane having the formula (I) ##SPC1## and a process for producing this compound. This compound is useful as a perfume.

Medicament For Irritable Bowel Syndrome

The invention relates to a medicament for IBS, which comprises a dual antagonist for 5-HT 2B and 5-HT 7 receptors having selective binding affinities for 5-HT 2B and 5-HT 7 receptors. The pharmaceutical composition of the invention is useful as a drug which is excellent in the therapeutic effect on IBS and shows lessened side effects occurring in the existing remedies for IBS, because it showed good pharmacological actions in comparison with the case of independently using a 5-HT 2B receptor antagonist having selective binding affinity for 5-HT 2B receptor or a 5-HT 7 receptor antagonist having selective binding affinity for 5-HT 7 receptor.

3.2.1-bicyclo-octane compounds

The present invention relates to novel compounds and their use in fragrance compositions. Novel 3.2.1-bicyclo-octane compounds of the present invention are represented by formula: wherein R is selected from the group consisting of carbonyl and [1,3]dioxolane; R′ is selected from the group consisting of hydrogen and allyl; or R and R′ taken together represent

Mixtures of dimethyl-tricyclo (5.2.1.02,6) decane derivatives together with their preparation and use as a scent-and flavor materials

Mixtures of new dimethyl-tricyclo[5.2.1.0 2 ,6 ]decane derivatives, notably the primary isomers of the common formula A, wherein R 1 and R 2 mean either methyl group or hydrogen, one of the substituents being a methyl group and the other hydrogen, R 3 and R 4 mean either methyl group or hydrogen, one of the substituents being a methyl group and the other hydrogen, and X indicates the π-system of a C-C double bond or an epoxide system, can advantageously be used as new acent- and flavor materials. The compounds of the common formula A, were prepared by hydrogenation of dimeric methylcyclopentadiene selectively in the norbornane part and when desired by epoxidation of the remaining double bond. ##STR1##

1,2,6-Trimethyltricyclo [5,3,2,0 → 2.7 →] dodeca-5-ene in the cis-decalin form and process for its preparation

Diepoxides of omega-alkenylbicycloheptyl compounds

Patent JPS50142553A

Adamantane derivative, method for producing the same, resin composition containing the same, and use of the same

一种杂环铼离子液体及其制备方法和在催化烯烃环氧化反应中的应用

本发明涉及一种杂环铼离子液体及其制备方法和在催化烯烃环氧化反应中的应用。采用的技术方案是：取AgReO 4 置于Schlenk管中，在氮气保护下，加入CH 3 CN溶液，室温搅拌，加入定量的SiMe 3 Cl，搅拌10‑50min后，逐滴加入N‑甲基咪唑，或吡啶，或吗啉，或喹啉，或哌啶，关闭氮气，继续搅拌，30‑80℃下反应1‑5h，过滤除去固体，然后旋转蒸发除溶剂，乙醚清洗，真空干燥，制得杂环铼离子液体。以杂环铼离子液体作为催化剂，催化烯烃环氧化反应，产率可达97％。本发明用杂环铼离子液体做催化剂，工艺简单，反应绿色无污染，催化剂可循环利用，保护了环境，实现了经济效益和社会效益的最大化。

Process for epoxidizing crude polyenes

シクロドデセン又はトリシクロデセン−３のエポキシド化法

Carbocyclic sulfone ror modulators

Described are RORγ modulators of the formula (I), or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates, or prodrugs thereof, wherein all substituents are defined herein. Also provided are pharmaceutical compositions comprising the same. Such compounds and compositions are useful in methods for modulating RORγ activity in a cell and methods for treating a subject suffering from a disease or disorder in which the subject would therapeutically benefit from modulation of RORγ activity, for example, autoimmune and/or inflammatory disorders.

Limonene-based (meth)acrylates for use in 3d printing