06-08-2020 дата публикации
Номер: US20200247762A1
Принадлежит:
Provided herein, inter alia, are methods and compounds for modulating K-Ras treating cancer. 2. (canceled)5. The compound of claim 1 , wherein the compound is of Formula (I) claim 1 , or a pharmaceutically acceptable salt thereof claim 1 , wherein:Ring A is phenyl;{'sup': 1', '1', '1', '1', '1D', '1A', '1B', '1A', '1B', '1A', '1B', '1A', '1B', '1A', '1B', '1A', '1B', '1C', '1C', '1A', '1B', '1D', '1A', '1D', '1A', '1C', '1A', '1C', '1A', '1C', '1', '1', '1, 'sub': 3', '2', '2', 'n1', 'v1', 'm1', '2', '3', '2', '2, 'Ris independently halogen, —CX, —CHX, —CHX, —CN, —SOR, —SONRR, —NHNRR, —ONRR, —NHC═(O)NHNRR, —NHC(O)NRR, —N(O), —NRR, —C(O)R, —C(O)—OR, —C(O)NRR, —OR, —NRSOR, —NRC(O)R, —NRC(O)OR, —NROR, —OCX, —OCHX, —OCHX, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, or substituted or unsubstituted heterocycloalkyl; or'}{'sup': '1', 'two adjacent Rsubstituents may optionally be joined to form a substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;'}z1 is an integer from 0 to 4;{'sup': 2', '2', '2', '2', '2A', '2A', '2A', '2B, 'sub': 3', '2', '2, 'Ris independently hydrogen, —CX, —CHX, —CHX, —C(O)R, —C(O)OR, —C(O)NRR, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;'}{'sup': '1', 'Lis a bond, substituted or unsubstituted alkylene, or substituted or unsubstituted cycloalkylene;'}{'sup': 3', '3', '3', '3', '3', '3, 'sub': '2', 'Lis a bond, —S(O)—, —N(R)—, —O—, —S—, —C(O)—, —C(O)N(R)—, —N(R)C(O)—, —N(R)C(O)NH—, —NHC(O)N(R)—, —C(O)O—, —OC(O)—, substituted or unsubstituted alkylene, substituted or unsubstituted heteroalkylene, substituted or unsubstituted cycloalkylene, substituted or unsubstituted ...
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