01-04-2021 дата публикации
Номер: US20210094953A1
Принадлежит:
Disclosed in the present invention are a pyrazolo [1,5-a]pyrimidine derivative having a structure of formula (I), a pharmaceutical composition comprising the compound of formula (I), and use of the compound in the preparation of a medicament for preventing or treating diseases associated with tropomyosin receptor kinases, in particular for preventing or treating cancers associated with tropomyosin receptor kinases. Each substituent in formula (I) has the same definition as that in the description. 3. The compound according to claim 2 , wherein:{'sup': 1', '6', '8', '7', '7', '7', '7, 'sub': 1', '8', '3', '8', '2', '8', '2', '8', '2', '1', '8', '3', '8', '1', '8, 'Ris selected from H, C-Calkyl, C-Ccycloalkyl, C-Calkenyl or C-Calkynyl, and optionally further substituted with one or more substituents selected from deuterium, halogen, hydroxyl, cyano, —NRR, —NRCOR, —COR, —SOR, —SOR, C-Calkyl, C-Ccycloalkyl, C-Calkoxy, or a 4-10 membered heterocyclic group;'}{'sup': 2', '4', '6', '8', '6', '5', '5', '5', '5, 'sub': 1', '8', '3', '8', '2', '8', '2', '8', '2', '1', '8', '3', '8', '1', '8, 'Rand Rare each independently selected from H, C-Calkyl, C-Ccycloalkyl, C-Calkenyl or C-Calkynyl, and optionally further substituted with one or more substituents selected from deuterium, halogen, hydroxyl, cyano, —NRR, —NRCOR, —COR, —SOR, —SOR, C-Calkyl, C-Ccycloalkyl, C-Calkoxy, or a 4-10 membered heterocyclic group;'}{'sup': 5', '7', '8, 'sub': 1', '8', '3', '8, 'Rand Rare each independently selected from H, C-Calkyl, C-Ccycloalkyl, or —NR;'}{'sup': 6', '8, 'sub': 1', '8', '3', '8, 'Rand Rare each independently selected from H, C-Calkyl, or C-Ccycloalkyl;'}{'sup': 1', '2', '4, 'sub': 3', '8, 'alternatively, any two of R, Rand Rcan independently form a C-Ccycloalkyl group or a 4-10 membered heterocyclic group;'}{'sup': '3', 'Ris halogen; and'}X is selected from CH or N.4. The compound according to claim 3 , wherein:{'sup': 1', '6', '8', '6', '7', '7', '7', '7, 'sub': 1', '8', '3', '8', ...
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