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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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Поддерживает ввод нескольких поисковых фраз (по одной на строку). При поиске обеспечивает поддержку морфологии русского и английского языка
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Применить Всего найдено 6256. Отображено 100.
05-01-2012 дата публикации

Bile salt adjuvant for animals for improving fat utilization efficiency in the bodies of animals, and animal feed comprising same

Номер: US20120004304A1
Автор: Kwan-Sik Yun
Принадлежит: KIMIN Inc

The present invention relates to a bile salt adjuvant for animals for improving fat utilization efficiency in the bodies of the animals, and to animal feed comprising same. More particularly, the present invention relates to a bile salt adjuvant for animals comprising sodium stearoyl-2-lactylate. The adjuvant is used in animal feed to improve fat utilization efficiency in the bodies of livestock when ingested by said livestock, thereby reducing the amount of fat required to be used in animal feed and improving productivity.

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Номер записи: 1
23-02-2012 дата публикации

Co-deposition methods for the fabrication of organic optoelectronic devices

Номер: US20120045862A1
Автор: Chao Wu, Mark E. Thompson, Zhiwei Liu
Принадлежит: University of Southern California USC

A method for fabricating an OLED by preparing phosphorescent metal complexes in situ is provided. In particular, the method simultaneously synthesizes and deposits copper (I) complexes in an organic light emitting device. Devices comprising such complexes may provide improved photoluminescent and electroluminescent properties.

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Номер записи: 2
05-04-2012 дата публикации

Ionic liquids, the method for preparing the same and method for removing acetylenes from olefin mixtures using the ionic liquids

Номер: US20120083642A1
Автор: Byoung Sung Ahn, Gyeong Taek Gong, Hoon Sik Kim, Hyun Joo Lee, Jin-Hyung Kim
Принадлежит: Korea Advanced Institute of Science and Technology KAIST

There are provided an ionic liquid having ether group(s) in which a copper(I) compound is included, a method for preparing the same, and a method for removing traces amounts of acetylene-based hydrocarbon compounds included in olefin by absorption or extraction using the same. When the disclosed solution is used, oxidation of Cu(I) to Cu(II) is prevented since CuX is stabilized by the ionic liquid. Thus, selective removal efficiency of acetylenic compounds is improved greatly while the removal performance is retained for a long period of time. Further, since the solution according to the present disclosure is applicable as an extractant as well as an absorbent, the associated operation is simple and apparatus cost can be decreased.

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Номер записи: 3
03-05-2012 дата публикации

Nitrogen-Containing Ligands And Their Use In Atomic Layer Deposition Methods

Номер: US20120108062A1
Автор: David Thompson, Jeffrey W. Anthis
Принадлежит: Applied Materials Inc

Methods for deposition of elemental metal films on surfaces using metal coordination complexes comprising nitrogen-containing ligands are provided. Also provided are nitrogen-containing ligands useful in the methods of the invention and metal coordination complexes comprising these ligands.

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Номер записи: 4
05-07-2012 дата публикации

Compositions comprising functionalized carbon-based nanostructures and related methods

Номер: US20120171093A1
Автор: Ezequiel Schmois, John B. Goods, Joseph Walish, Stefanie Sydlik, Timothy M. Swager, Wiktor Lewandowski, William R. Collins
Принадлежит: Massachusetts Institute of Technology

The present invention generally relates to compositions comprising and methods for forming functionalized carbon-based nanostructures.

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Номер записи: 5
16-08-2012 дата публикации

Electroluminescent device using azomethine-lithium-complex as electron injection layer

Номер: US20120205638A1
Автор: Poopathy Kathirgamanathan, Yun Fu Chan
Принадлежит: Merck Patent GmBH

In OLEDs, improved efficiency is obtained by compounds which can form inter alia electron injection layers of the formula (I) wherein R 1 is a 1-5 ring aryl (including polycyclic), aralkyl or heteroaryl group which is optionally substituted with one or more C 1 -C 4 alkyl, alkoxy or cyano; R 2 and R 3 together form a 1-5 ring aryl (including polycyclic), aralkyl or heteroaryl group which is optionally substituted with C 1 -C 4 alkyl, alkoxy or cyano; R 4 is hydrogen, C 1 -C 4 alkyl or aryl; and Ar is monocyclic, bicyclic or tricyclic aryl or heteroaryl which is optionally substituted with one or more C 1 -C 4 -alkyl or alkoxy groups, or an oligomer thereof.

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Номер записи: 6
23-08-2012 дата публикации

Preparation of metal-catecholate frameworks

Номер: US20120215015A1
Автор: Felipe GANDARA-BARRAGAN, Omar M. Yaghi, Shun Wan, Zheng Lu
Принадлежит: UNIVERSITY OF CALIFORNIA

The disclosure provides for metal catecholate frameworks, and methods of use thereof, including gas separation, gas storage, catalysis, tunable conductors, supercapacitors, and sensors.

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Номер записи: 7
25-10-2012 дата публикации

Heterodimers of Glutamic Acid

Номер: US20120269726A1
Автор: Craig N. Zimmerman, John W. Babich, Kevin P. Maresca
Принадлежит: Molecular Insight Pharmaceuticals Inc

Compounds of Formula (Ia) wherein R is a C 6 -C 12 substituted or unsubstituted aryl, a C 6 -C 12 substituted or unsubstituted heteroaryl, a C 1 -C 6 substituted or unsubstituted alkyl or —NR′R′, Q is C(O), O, NR′, S, S(O) 2 , C(O) 2 (CH2)p Y is C(O), O, NR′, S, S(O) 2 , C(O) 2 (CH2)p Z is H or C 1 -C 4 alkyl, R′ is H, C(O), S(O) 2 , C(O) 2 , a C 6 -C 12 substituted or unsubstituted aryl, a C 6 -C 12 substituted or unsubstituted heteroaryl or a C 1 -C 6 substituted or unsubstituted alkyl, when substituted, aryl, heteroaryl and alkyl are substituted with halogen, C 1 -C 12 heteroaryl, —NR′R′ or COOZ, which have diagnostic and therapeutic properties, such as the treatment and management of prostate cancer and other diseases related to NAALADase inhibition. Radiolabels can be incorporated into the structure through a variety of prosthetic groups attached at the X amino acid side chain via a carbon or hetero atom linkage.

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Номер записи: 8
25-10-2012 дата публикации

Metal delivery agents and therapeutic uses of the same

Номер: US20120270850A1
Автор: Anthony Robert White, Kevin Jeffrey Barnham, Paul Stephen Donnelly
Принадлежит: University of Melbourne

The present invention relates to metal complexes, processes for their preparation and their use as pharmaceutical or veterinary agents, in particular for the treatment of conditions in which metal delivery can prevent, alleviate or ameliorate the condition. There are a number of clinical conditions which are caused by or associated with abnormal levels of metals (typically low metal levels). Conditions in of this type include cancer and conditions characterised by or associated with oxidative damage, more specifically neurodegenerative conditions such as Alzheimer's disease, Parkinson's disease or Huntington's disease. The invention also relates to ligands useful in the preparation of metal complexes of this type.

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Номер записи: 9
06-12-2012 дата публикации

Process for the preparation of perfluoroalkylcyano- or perfluoroalkylcyanofluoroborates

Номер: US20120309981A1
Автор: Jan Sprenger, Maik Finze, Michael Schulte, Nikolai (Mykola) Ignatyev, Walter Frank
Принадлежит: Merck Patent GmBH

The invention relates to a process for the preparation of salts having perfluoroalkyltricyano- or perfluoroalkylcyanofluoroborate anions, ((per)fluoro)phenyltricyano- or ((per)fluoro)phenylcyanofluoroborate anions, phenyltricyanoborate anions which are mono- or disubstituted by perfluoroalkyl groups having 1 to 4 C atoms or phenylcyanofluoroborate anions which are mono- or disubstituted by perfluoroalkyl groups having 1 to 4 C atoms, by reaction of alkali metal trifluoroperfluoroalkylborate with trialkylsilyl cyanide and a subsequent salt-exchange reaction or by direct reaction of an organic trifluoroperfluoroalkyl borate with trialkylsilyl cyanide.

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Номер записи: 10
14-03-2013 дата публикации

Methods and systems for forming boronic acids and intermediates thereof

Номер: US20130066115A1
Автор: Catherine A. MENNING, D. Wayne Blaylock, Mark V. M. Emonds
Принадлежит: DOW AGROSCIENCES LLC

Methods for forming boronic acids, and intermediates thereof, are disclosed. The method may include mixing a 1-chloro-2-substituted-3-fluorobenzene starting material with an alkyllithium in a first reactor to form a reaction mixture. The 1-chloro-2-substituted-3-fluorobenzene starting material may react with the alkyllithium to form a lithiated intermediate. The reaction mixture may be continuously transferred to a second reactor and a borate may be continuously introduced to form a boronate. The boronic acids may be formed by treating the boronate with aqueous potassium hydroxide followed by acidification. Such methods may provide continuous formation of the boronic acids and may reduce an amount of a reactive intermediate present during processing as well as cycle times. Systems for forming the boronic acids are also disclosed.

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Номер записи: 11
04-04-2013 дата публикации

CARBOXYLATION CATALYSTS

Номер: US20130085276A1
Автор: Cazin Catherine, NOLAN Steven P.
Принадлежит:

The use of a complex of the form Z—M—OR in the carboxylation of a substrate is described. The group Z is a two-electron donor ligand, M is a metal and OR is selected from the group consisting of OH, alkoxy and aryloxy. The substrate may be carboxylated at a C—H or N—H bond. The metal M may be copper, silver or gold. The two-electron donor ligand may be a phosphine, a carbene or a phosphite ligand. Also described are methods of manufacture of the complexes and methods for preparing isotopically labelled caboxylic acids and carboxylic acid derivatives. 134-. (canceled)25. A method of carboxylation of a substrate , the method comprising;{'sub': '2', 'contacting a complex of the form Z—M—OR ,wherein the group Z is a two-electron donor ligand, M is a metal, and OR is selected from the group consisting of OH, alkoxy and aryloxy; with a substrate and a source of CO.'}26. The method according to claim 25 , wherein the metal M is selected from the group consisting of copper claim 25 , silver and gold.27. The method according to claim 25 , wherein the carboxylation is carried out in the presence of a base.28. The method according to claim 27 , wherein the base is an alkali metal hydroxide or alkoxide.29. The method according to claim 25 , wherein the two-electron donor ligand Z is selected from the group consisting of phosphines claim 25 , carbenes claim 25 , or phosphites.30. The method according to claim 29 , wherein the two-electron donor ligand Z is a nitrogen containing heterocyclic carbene ligand.33. The method according to claim 26 , wherein the complex is selected from the group consisting of: [M(OH)(IMes)] claim 26 , [M(OH)(SIMes)] claim 26 , [M(OH)(IPr)] claim 26 , [M(OH)(ItBu)] claim 26 , and [M(OH)(SIPr)] claim 26 , where M is Au claim 26 , Ag or Cu.34. The method according to claim 25 , wherein the substrate is carboxylated at a C—H or N—H bond.35. The method according to claim 25 , wherein the substrate is a substituted or unsubstituted aromatic compound.36. The ...

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Номер записи: 12
18-04-2013 дата публикации

COMPOSITE OF ORGANIC COMPOUND AND COPPER NANOPARTICLES, COMPOSITE OF ORGANIC COMPOUND AND COPPER(I) OXIDE NANOPARTICLES, AND METHODS FOR PRODUCING THE COMPOSITES

Номер: US20130095320A1
Автор: Jin Ren-Hua, Kawamura Kaori, SANO Yoshiyuki, Uota Masafumi
Принадлежит: DIC CORPORATION

Provided is a composite including copper nanoparticles or copper(I) oxide nanoparticles and a thioether-containing organic compound represented by X(OCHCHR)OCHCH(OH)CHSZ [X represents an alkyl group; Rrepresents a hydrogen atom or a methyl group; n represents an integer of 2 to 100; Ris independent between repeating units and may be the same or different; and Z represents an alkyl group, an allyl group, an aryl group, an arylalkyl group, —R—OH, —R—NHR, or —R—(COR)(where Rrepresents a saturated hydrocarbon group; Rrepresents a hydrogen atom, an acyl group, an alkoxycarbonyl group, or a benzyloxycarbonyl group; Rrepresents a hydroxy group, an alkyl group, or an alkoxy group; and m represents 1 to 3)]. Provided is a method for producing a composite of an organic compound and copper nanoparticles or a composite of an organic compound and copper(I) oxide nanoparticles, the method including reducing a copper compound in the presence of a thioether-containing organic compound represented by the general formula (1) above. 110-. (canceled)11. A composite of an organic compound and copper nanoparticles , the composite comprising a thioether-containing organic compound (A) represented by a general formula (1) below and copper nanoparticles (B){'br': None, 'sub': 2', 'n', '2', '2, 'sup': '1', 'X—(OCHCHR)—O—CH—CH(OH)—CH—S—Z\u2003\u2003(1)'}{'sub': 1', '8', '2', '12', 'm', '1', '4', '2', '4', '2', '4', '1', '4', '1', '8', '1', '4', '1', '8, 'sup': 1', '1', '2', '2', '3', '2', '4', '2', '3', '4, '[in the formula (1), X represents a Cto Calkyl group; Rrepresents a hydrogen atom or a methyl group; n represents a repeating number, an integer of 2 to 100; Ris independent between repeating units and may be the same or different; and Z represents a Cto Calkyl group, an allyl group, an aryl group, an arylalkyl group, —R—OH, —R—NHR, or —R—(COR)(where Rrepresents a Cto Csaturated hydrocarbon group; Rrepresents a hydrogen atom, a Cto Cacyl group, a Cto Calkoxycarbonyl group, or a ...

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Номер записи: 13
16-05-2013 дата публикации

SELF-DECONTAMINATING METAL ORGANIC FRAMEWORKS

Номер: US20130123563A1
Автор: Chen Banglin, Lee Yongwoo, Modzelewski Thomasz, Puglia John P., Weiss Steven E.
Принадлежит:

A self-decontaminating metal organic framework including an acid linked to a metal producing a metal organic framework configured for the sorption of chemical warfare agents and/or toxic industrial chemicals, the metal organic framework including reactive sites for the degradation of the agents and chemicals. 1. A method for producing a self-decontaminating metal organic framework , the method comprising:combining an acid with a linking agent and a metal to produce a self-decontaminating metal organic framework for sorption of chemical warfare agents and/or toxic industrial chemicals, the self-decontaminating metal organic framework including reactive sites for the degradation of said agents and chemicals.2. The method of in which the acid is a triple bonded acid.3. The method of in which the acid is acetylenedicareoxylic acid (ADA).4. The method of in which the metal is copper nitrate.5. The method of in which the self-decontaminating metal organic framework is linked to the metal with a linking agent.6. The method of in which the linking agent includes Pyrazine claim 5 , 2 claim 5 ,6-dimethylpyrazine claim 5 , 2-6-dichloropyrazine claim 5 , dipyridylethlene claim 5 , 4 claim 5 ,4′-dipyridyl claim 5 , or 2 claim 5 ,3 claim 5 ,5 claim 5 ,6-tetramethylpyrazine.7. The method of further including the step of adding an enzyme to the metal organic framework to assist in the degradation of said agents and chemical.8. The method of in which the size of the pores of the self-decontaminating metal organic framework are tailored for specific said agents and chemicals.9. The method of in which the surface area of the self-decontaminating metal organic framework is tailored for specific said agents and chemicals.10. A method of absorbing and degrading chemical warfare agents and toxic industrial chemicals claim 1 , the method comprising:adding a self-decontaminating metal organic framework to fabric or filter material, the self-decontaminating metal organic framework comprising ...

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Номер записи: 14
30-05-2013 дата публикации

METHOD OF SYNTHESIZING A COMPLEX [CU(NNS)CL] ACTIVE AGAINST THE MALARIA PARASITE PLASMODIUM FALCIPARUM

Номер: US20130137872A1
Автор: Kiremire Enos
Принадлежит:

Metal complex of Copper (II) containing a dithio-based ligand have been synthesized and characterized by elemental analysis, mass spectrometry, Proton NMR and FT-IR spectrometry. A single crystal X-ray structure of the copper complex has been analyzeThis paper describes the synthesis and characterization of the said metal complex containing deprotonated 3-[1-(2-pyridyl) ethylidene]hydrazinecarbodithioate ligand (FIG. ). 119-. (canceled)20. A method of producing a copper ligand chloride complex (CuLCl) having biological activity against a malaria parasite includes providing a source of 3-[1-(2-pyridyl) ethylidene]hydrazinecarbodithioate ligands (L) , deprotonating the ligands to form deprotonated ligands (L−) , contacting the deprotonated ligands with a copper chloride compound under conditions suitable to form the copper ligand chloride complex , and recovering the copper ligand chloride complex so formed.21. A method according to claim 20 , wherein the copper chloride compound is copper chloride dihydrate.22. A method according to claim 20 , wherein the source of ligands (L−) and copper chloride compound are provided respectively in solution claim 20 , the respective ligand and copper chloride solutions being mixed together to form a precipitate of the copper ligand chloride complex.23. A method according to claim 22 , wherein the copper chloride compound is dissolved in water to form the copper chloride solution and the source of ligands is dissolved in ethanol to form the ligand solution.24. A method according to claim 22 , wherein the copper ligand chloride complex precipitate is filtered off claim 22 , washed claim 22 , dried claim 22 , and then recrystallized.25. A method according to claim 24 , wherein the copper ligand chloride complex precipitate is recrystallized from acetone.26plasmodium falciparum.. A method according to claim 20 , wherein the copper ligand chloride complex is potent against the malaria parasite27plasmodium falciparum.. A method ...

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Номер записи: 15
30-05-2013 дата публикации

Catalyst for Akili-Free Purification of Oil Raw Materials from Mercaptans

Номер: US20130137888A1
Автор: Irina Tarkhanova, Sergey Chernyshev, Vladmir Konovalov
Принадлежит: Greendane Ltd

A catalyst for alkali-free purification of oil raw materials includes a solid metalocomplex or a liquid metalocomplex with a general formula (Cu M Cl)20(Li)2̂(L 2 )î, where Li is amino alcohol, L2 is acetonitryl or single atom alcohol.

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Номер записи: 16
06-06-2013 дата публикации

SYSTEM AND METHOD FOR GENERATING AND/OR SCREENING POTENTIAL METAL-ORGANIC FRAMEWORKS

Номер: US20130139686A1
Автор: Farha Omar K., Hupp Joseph T., Leaf Michael, Snurr Randall Q., WILMER CHRISTOPHER E.
Принадлежит: Northwestern University

A system and method for systematically generating potential metal-organic framework (MOFs) structures given an input library of building blocks is provided herein. One or more material properties of the potential MOFs are evaluated using computational simulations. A range of material properties (surface area, pore volume, pore size distribution, powder x-ray diffraction pattern, methane adsorption capability, and the like) can be estimated, and in doing so, illuminate unidentified structure-property relationships that may only have been recognized by taking a global view of MOF structures. In addition to identifying structure-property relationships, this systematic approach to identify the MOFs of interest is used to identify one or more MOFs that may be useful for high pressure methane storage. 1. A metal organic framework (MOF) comprising a polymeric crystalline structure comprising the coordination product of a metal component comprising a metal center selected from ZnO , Zn , Cu , VOand ZrO , an organic ligand component selected from the ligands of and combinations thereof , and optionally a solvent.2. The MOF of claim 1 , wherein said metal center is selected from Cuand ZnO.3. The MOF of in a composition comprising one or more of a binder claim 1 , an organic viscosity-enhancing agent claim 1 , and a liquid.4. The MOF of substantially absent a solvent.5. The MOF of comprising a sorbed gas claim 1 , said gas selected from hydrogen claim 1 , oxygen claim 1 , nitrogen claim 1 , the noble gases claim 1 , acetylene claim 1 , methane claim 1 , ethane claim 1 , propane claim 1 , natural gases claim 1 , synthesis gases claim 1 , carbon monoxide claim 1 , carbon dioxide claim 1 , arsine claim 1 , hydrogen selenide claim 1 , and combinations thereof.6. The MOF of comprising sorbed natural gas.8. The MOF of substantially absent a solvent.9. The MOF of in a composition comprising one or more of a binder claim 7 , an organic viscosity-enhancing agent claim 7 , and a liquid. ...

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Номер записи: 17
13-06-2013 дата публикации

Labeled Alginate Conjugates for Molecular Imaging Applications

Номер: US20130149242A1
Автор: Deckwerth Thomas L., Meglasson Martin D., Ruan Fuqiang
Принадлежит: Ikaria Development Subsidiary One LLC

Described are bifunctional NOTA-based derivatives capable of conjugating with alginate and with metal ions, as well as NOTA-alginate conjugates which can be labeled with stable or radioactive metal ions. Also described are conjugation methods of the bifunctional NOTA-based linker with alginate, and methods of using radiometal-labeled NOTA-alginate conjugates or other radio-labeled alginate conjugates as imaging reagents. 2. The compound of claim 1 , wherein the compound further comprises a stable or radioactive metal ion chelated by the 1 claim 1 ,4 claim 1 ,7-triazacyclononane-1 claim 1 ,4 claim 1 ,7-triacetic acid moiety.3. The compound of claim 2 , wherein the stable or radioactive metal ion comprises a gallium ion.4. The compound of claim 2 , wherein the radioactive metal ion comprises Cu claim 2 , Cu claim 2 , Cu claim 2 , Cu claim 2 , Cu claim 2 , or In.6. The alginate conjugate of claim 5 , wherein the conjugate further comprises a stable or radioactive metal ion chelated by the 1 claim 5 ,4 claim 5 ,7-triazacyclononane-1 claim 5 ,4 claim 5 ,7-triacetic acid moiety of the conjugate.7. The alginate conjugate of claim 6 , wherein the stable or radioactive metal ion comprises a gallium ion.8. The alginate conjugate of claim 6 , wherein the radioactive metal ion comprises Cu claim 6 , Cu claim 6 , Cu claim 6 , Cu claim 6 , Cu claim 6 , or In.9. A method of imaging in a mammal comprising:administering a radio-labeled alginate conjugate to a mammal; andimaging the temporal and spatial distribution of the radio-labeled alginate conjugate.11. The method of claim 10 , wherein the stable or radioactive metal ion comprises a gallium ion.12. The method of claim 10 , wherein the radioactive metal ion comprises Cu claim 10 , Cu claim 10 , Cu claim 10 , Cu claim 10 , Cu claim 10 , or In.13. The method of claim 9 , wherein the alginate is conjugated to an iodinated tyramine or tyramine derivative.14. The method of claim 9 , wherein the radio-labeled alginate conjugate is ...

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Номер записи: 18
27-06-2013 дата публикации

COPPER ORGANIC METAL, METHOD FOR PREPARING COPPER ORGANIC METAL AND COPPER PASTE

Номер: US20130161571A1
Автор: KIM Dong Hoon, Kwon Ji Han, LEE Kwi Jong
Принадлежит: SAMSUNG ELECTRO-MECHANICS CO., LTD.

Disclosed herein are a copper organic metal, a method for preparing a copper organic metal and a copper paste. The copper organic metal is constituted to combine a copper atom, [R—CO] and amine based ligand (L), thereby making it possible to be subjected to a low temperature sintering process and having an improved conductivity at the time of forming a conductive pattern as compared to the related art. 2. The copper organic metal according to claim 1 , wherein the amine based ligand includes alkylamine.3. The copper organic metal according to claim 2 , wherein the alkylamine is any one material selected from R—NH claim 2 , R—NH—R′ claim 2 , or R—N.4. The copper organic metal according to claim 1 , wherein the amine based ligand includes a hydroxyl (—OH) group.5. The copper organic metal according to claim 1 , wherein the amine based ligand includes HO—R—NH.6. A method for preparing a copper organic metal having an amine based ligand comprising:preparing a first solution by dissolving alkanoic acid or fatty acid in an aqueous sodium hydroxide solution or an aqueous potassium hydroxide solution;mixing the first solution and a second solution having a dissolved copper salt therein; andseparating and purifying a copper organic metal from the mixed solution including the first solution and the second solution.7. A method for preparing a copper organic metal having an amine based ligand comprising:preparing a first solution by dissolving alkanoic acid or fatty acid in an aqueous sodium hydroxide solution or an aqueous potassium hydroxide solution;mixing the first solution and a second solution having a dissolved copper salt therein;separating and purifying a copper organic metal from the mixed solution including the first solution and the second solution; andreacting the separated and purified copper organic metal with amine based solvent.8. The method according to claim 7 , wherein the amine based ligand includes alkylamine.9. The method according to claim 8 , wherein ...

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Номер записи: 19
27-06-2013 дата публикации

SILAFLUORENE METALLOPORPHYRIN- BENZENE ORGANIC SEMICONDUCTOR MATERIAL AND PREPARING METHOD AND USES THEREOF

Номер: US20130165646A1
Автор: Huang Jie, liu Yijin, Zhou Mingjie
Принадлежит:

A silafluorene metalloporphyrin-benzene organic semiconductor material and preparing method and uses thereof are provided. The structure of the silafluorene metalloporphyrin-benzene organic semiconductor material is defined by structure formula (I); wherein: n is an integer between 1 and 100, R, R, R, Rare H, alkyl with C-C, phenyl, alkyl benzene or alkoxyl benzene containing one or more C-C, M is a metal ion. The silafluorene metalloporphyrin-benzene organic semiconductor material has good solubility, high carrier mobility, strong absorbance, wide absorbent range to light and elevated utilization ratio of solar light. Besides, the process of the preparing method is simple and easy to operate and control. 2. The silafluorenyl metalloporphyrin-benzene organic semiconductor material according to claim 1 , wherein said metal ion is Zn claim 1 , Cu claim 1 , Fe claim 1 , Co claim 1 , Cd claim 1 , Pt claim 1 , Zr claim 1 , Mn claim 1 , Ni claim 1 , Pb or Sn.4. The preparing method according to claim 3 , wherein claim 3 , in said step S1 claim 3 , molar ratio of said dipyrromethane claim 3 , the first silafluorene derivative and the second silafluorene derivative is a:(b+c)=1:1 claim 3 , where a≧b>0 claim 3 , and c≧0; said the first catalyst is propionic acid claim 3 , trifluoroacetic acid; said oxidant is 2 claim 3 ,3-dichloro-5 claim 3 ,6-dicyano-1 claim 3 ,4-benzoquinone; said the first organic solvent is one or two of trichloromethane and dichloromethane.5. The preparing method according to claim 3 , wherein claim 3 , in said step S2 claim 3 , the molar ratio of used said silafluorenyl porphyrin derivative to used said brominating agent is in the range of 1:2 to 1:5; said brominating agent is N-bromobutanimide; said the second organic solvent is at least one of tetrahydrofuran claim 3 , chloroform claim 3 , dimethylformamide and orthodichlorobenzene.6. The preparing method according to claim 3 , wherein claim 3 , in said step S3 claim 3 , molar ratio of said dibromo- ...

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Номер записи: 20
04-07-2013 дата публикации

Novel Imidazolium Salts and Carbene Metal Complexes Based Thereon for Use as Bioanalytical Markers for Biomolecules

Номер: US20130171071A1
Автор: Kuehl Olaf
Принадлежит: ERNST-MORITZ-ARNDT-UNIVERSITAT GREIFSWALD

The present invention relates to imidazolium salts, particularly imidazolium salts of the general formula I as well as the respective carbene metal complexes and their utilisation as bioanalytical tags for biomolecules. 2. Imidazolium salts according to claim 1 , wherein the groups R claim 1 , R claim 1 , and R claim 1 , where applicable claim 1 , are the same or different and chosen from the group of C-C-n-alkyl groups.3. Imidazolium salts according to claim 1 , wherein n claim 1 , m claim 1 , and q claim 1 , where applicable claim 1 , are zero or 1 and b and l are zero.4. Imidazolium salts according to claim 1 , wherein R″ is a C-C-n-alkyl group.7. Carbene metal complexes according to claim 6 , wherein the metal is chosen from the group consisting of copper claim 6 , iron claim 6 , ruthenium claim 6 , nickel claim 6 , and palladium or from the group consisting of technetium claim 6 , rhenium and cobalt.8. Carbene metal complexes according to claim 6 , wherein the ligand L is chosen from the group consisting ofCO;nitrile;isonitrile;nitrosyl;halogenide ion;hydrogen atom;{'sub': 1', '12', '6', '14', '1', '12', '6', '14', '1', '12', '6', '14', '1', '12', '6', '14', '6', '14', '1', '12', '1', '12, 'C-C-alkyl anion, allyl anion, methylallyl anion, benzyl anion, C-C-aryl anion, C-C-alkoxy anion, C-C-aryloxy anion, C-C-heteroalkyl anion, C-C-heteroaryl anion, C-C-heteroalkoxy anion, C-C-heteroaryloxy anion or C-C-heteroaryloxy anion, which is unsubstituted or the same or differently substituted by one or more C-C-alkyl groups or C-C-heteroalkyl groups, whereby the heteroatoms are chosen from the group B, Al, Ga, In, N, P, As, Sb, Bi, Si, Ge, Sn, Pb, O, S, Se, and Te and wherein the anions are unsubstituted or wholly or partially substituted with one or more than one, same, or different heteroatoms from the same group, in the form of functional groups, wherein the cyclic and aromatic systems are single rings or several annelated or isolated rings;'}primary, secondary, ...

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Номер записи: 21
04-07-2013 дата публикации

Anti-microbial metal organic framework

Номер: US20130171228A1
Автор: Russell Edward Morris
Принадлежит: University of St Andrews

The present invention relates to metal organic framework materials which possess anti-microbial properties. The present invention also provides methods of preparing such metal organic framework materials and uses of the metal organic framework materials to prevent or treat microbial infections, or provide surfaces which limit contamination by micro-organisms.

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Номер записи: 22
01-08-2013 дата публикации

Luminescent gold(iii) compounds for organic light-emitting devices and their preparation

Номер: US20130193428A1
Автор: Keith Man-Chung Wong, Mei-Yee Chan, Vivian Wing-Wah Yam, Vonika Ka-Man AU
Принадлежит: University of Hong Kong HKU

In one embodiment, the present invention provides a class of luminescent gold(III) compounds containing a tridentate ligand with one strong σ-donating group. The present invention also provides methods for synthesizing these compounds, as well as uses of these compounds as electrophosphorescent materials in phosphorescent organic light-emitting devices (OLEDs) to provide electroluminescence (EL).

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Номер записи: 23
15-08-2013 дата публикации

PHOTOLABILE CAGED TRANSITION METAL COMPLEXES AND METHODS OF USING THE SAME

Номер: US20130210793A1
Автор: Ciesienski Katie L., Franz Katherine J.
Принадлежит: Duke University

The present invention provides compounds of Formula I: 2. The compound of claim 1 , wherein Z is absent.3. The compound of claim 1 , wherein Z is a transition metal.4. The compound of claim 1 , wherein Z is a transition metal selected from the group consisting of copper claim 1 , platinum claim 1 , iron and zinc.5. The compound of claim 1 , wherein at least one adjacent pair of Rand Rtogether form a heteroaryl selected from the group consisting of pyrimidine claim 1 , thiazole claim 1 , thiophene claim 1 , isoquinoline claim 1 , imidazole claim 1 , and pyrroline.6. The compound of claim 1 , wherein Ris selected from the group consisting of: H claim 1 , alkyl claim 1 , alkoxy claim 1 , halo claim 1 , and sulfonate.7. The compound of claim 1 , wherein Ris selected from the group consisting of: H claim 1 , alkyl claim 1 , alkoxy claim 1 , halo claim 1 , and sulfonate.8. The compound of claim 1 , wherein Ris selected from the group consisting of: H claim 1 , alkyl claim 1 , alkoxy claim 1 , halo claim 1 , and sulfonate.9. The compound of claim 1 , wherein Ris selected from the group consisting of: H claim 1 , alkyl claim 1 , alkoxy claim 1 , halo claim 1 , and sulfonate.10. The compound of claim 1 , wherein Rand Rtogether form oxo.11. The compound of claim 1 , wherein each Ris independently selected from the group consisting of: H claim 1 , alkyl claim 1 , alkoxy claim 1 , halo claim 1 , and sulfonate.12. The compound of claim 1 , wherein each Ris independently selected from the group consisting of: H claim 1 , alkyl claim 1 , alkoxy claim 1 , halo claim 1 , and sulfonate.13. The compound of claim 1 , wherein each Ris independently selected from the group consisting of: H claim 1 , alkyl claim 1 , alkoxy claim 1 , and halo.14. The compound of claim 1 , wherein each Ris independently selected from the group consisting of: H claim 1 , alkyl claim 1 , alkoxy claim 1 , and halo.16. A composition comprising a compound of in a pharmaceutically acceptable carrier.1718-. ( ...

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Номер записи: 24
29-08-2013 дата публикации

Fluoroalkylation Methods And Reagents

Номер: US20130225815A1
Автор: Hiroyuki Morimoto, John F. Hartwig, Patrick Fier
Принадлежит: University of Illinois

A method of forming a fluorinated molecular entity includes reacting in a reaction mixture an aromatic halide, copper, a fluoroalkyl group, and a ligand. The aromatic halide includes an aromatic group and a halogen substituent bonded to the aromatic group. The ligand includes at least one group-V donor selected from phosphorus and an amine. The overall molar ratio of copper to aromatic halide in the reaction mixture is from 0.2 to 3. The method further includes forming a fluoroalkylarene including the aromatic group and the fluoroalkyl group bonded to the aromatic group. A composition, which may be used in the method, consists essentially of copper, the fluoroalkyl group, and the ligand, where the molar ratio of copper to the fluoroalkyl group is approximately 1.

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Номер записи: 25
05-09-2013 дата публикации

Cyclometalated Au(III) Complexes Suitable for Electroluminescent Devices

Номер: US20130231482A1
Автор: Alexander Zalan Claude Szentkuti, Jai Anand Garg Narayana RAO, Koushik Venkatesan
Принадлежит: Universitaet Zuerich

Monocyclometalated Au(III) complexes, cis-[(N̂C)AuL 1 L 2 ] and cis-[(N̂C)Au L 1 ̂L 2 ] represented by generic chemical formulae 1a and 1b respectively with ligands L 1 and L 2 being either similar (L 1 =L 2 ) or dissimilar (L 1 ≠L 2 ) but with at least one of either (L 1 or L 2 ) comprising a σ-donating carbanionic group is described here. Also described are Au(III) complexes of formula in which L 3 denotes a neutral donor ligand bound in a tridentate fashion. The complexes depicted by the formulae 1a, 1b and 1c in the present invention are suitable as emissive phosphorescent organometallic materials in OLEDs.

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Номер записи: 26
26-09-2013 дата публикации

METHOD FOR PRODUCING CYANOACETIC ACID, METHOD FOR PRODUCING CYANOACETIC ACID DERIVATIVE AND METHOD FOR PRODUCING METAL CONTAINING COMPOUND

Номер: US20130253213A1
Автор: Ikemizu Dai, ISHIDAI Keiko, IWAMOTO Ryohei, OOKUBO Kimihiko
Принадлежит: Konica Minolta Business Technologies, Inc.

Provided is a method for producing cyanoacetic acid in a hydrolysis reaction of a predetermined cyanoacetate in the presence of an acid catalyst. Further, are provided methods for producing a cyanoacetic acid derivative and a metal containing compound by using the produced cyanoacetic acid as a staring material. Herein, the method for producing cyanoacetic acid enables the content of a malonic acid byproduct generated in the hydrolysis reaction to be greatly lowered, allowing the produced cyanoacetic acid to be used as a starting material without any purification treatments. Those advantageous effects result in the great improvement in the purity and yields of the cyanoacetic acid derivative and the metal containing compound produced by said cyanoacetic acid. Accordingly, the above mentioned methods make it possible to produce cyanoacetic acid, the cyanoacetic acid derivative and the metal containing compound, as excellent in the productivity and economical efficiency. 2. The method for producing cyanoacetic acid according to claim 1 , the alcohol produced in the hydrolysis reaction is included in 0.5 to 20 mol % with respect to the produced cyanoacetic acid claim 1 , when hydrolysis reaction is completed.3. The method for producing cyanoacetic acid according to claim 1 , the cyanoacetate of the formula (1) is included in 0.5 to 2.0 mol % with respect to the produced cyanoacetic acid claim 1 , when the hydrolysis reaction is completed.4. The method for producing cyanoacetic acid according to claim 1 , wherein the acid catalyst is selected from a group of sulfuric acid claim 1 , hydrochloric acid claim 1 , acetic acid claim 1 , cyanoacetic acid claim 1 , phosphoric acid claim 1 , and p-toluenesulfonic acid.5. The method for producing cyanoacetic acid according to claim 1 , wherein the acid catalyst is used in 0.2 to 10 mol % with respect to the cyanoacetate of the formula (1) in the hydrolysis reaction.6. The method for producing cyanoacetic acid according to claim 5 ...

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Номер записи: 27
10-10-2013 дата публикации

Hydroxy Acid Complexes for Skin Antiaging, Acne, and Skin Whitening

Номер: US20130267483A1
Автор: GUPTA SHYAM K
Принадлежит: BIODERM RESEARCH

This invention relates to complexes of certain divalent and polyvalent d-orbital metals of first transition series of the Periodic Table of Elements, from Group IV to Group VI, and including molybdenum, having a hydroxy acid [HA] and an amino acid [AA] moiety concurrently bound to a single said metal and having a spirocyclic, bidentate chelate structure of formula (I). Upon topical application said metal complexes undergo enhanced skin penetration without causing skin irritation. The said metal complexes are useful for topical conditions that includes dry skin, xerosis, ichthyosis, dandruff, brownish spots, keratoses, melasma, lentigines, age spots, dark circles around eyes, skin pigmentation, topical inflammation, liver spots, pigmented spots, wrinkles, blemishes, skin lines, oily skin, acne, warts, eczema, pruritic skin, psoriasis, inflammatory dermatoses, disturbed keratinization, dandruff, bacterial infection, fungal infection, wound healing, body odor, and skin changes associated with aging; 2. A composition comprising the complex of claim 1 , wherein said composition treats a dermatological disorder.5. A composition comprising the complex of claim 1 , wherein said composition is for topical application.6. A composition of claim 2 , wherein said dermatological disorder is selected from the group consisting of dry skin claim 2 , dandruff claim 2 , age spots claim 2 , dark circles under the eyes claim 2 , skin pigmentation claim 2 , darkened skin claim 2 , skin wrinkles claim 2 , skin blemishes claim 2 , skin lines claim 2 , crow's feet claim 2 , oily skin claim 2 , acne claim 2 , warts claim 2 , eczema claim 2 , pruritic skin claim 2 , psoriasis claim 2 , disturbed keratinization claim 2 , skin changes associated with aging claim 2 , and combinations thereof.7. A composition of further comprising a carrier or base.8. A composition of claim 6 , wherein said dermatological disorder is dandruff.9. A composition of claim 6 , wherein said dermatological disorder is ...

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Номер записи: 28
17-10-2013 дата публикации

HIGHLY HEAT-RESISTANT PHTHALOCYANINE

Номер: US20130274462A1
Автор: Enomura Masakazu, Honda Daisuke, Maekawa Masaki
Принадлежит: M. TECHNIQUE CO., LTD.

The problem addressed by the present invention is to provide a high heat-resistant phthalocyanine. The phthalocyanine is separated by mixing a phthalocyanine separation solvent and a phthalocyanine solution wherein a phthalocyanine starting material is dissolved in a solvent. THe phthalocyanine is wherein having high heat resistance, the decomposition temperature of the separated phthalocyanine being at least 10° C. higher than the decomposition temperature of the phthalocyanine starting material. Also, the phthalocyanine solution may be the result of dissolving at least two types of phthalocyanine starting material in the solvent, the separated phthalocyanine being wherein containing a solid solvent of the at least two types of phthalocyanine starting material and by the decomposition temperature of the separated phthalocyanine being at least 10° C. higher than the decomposition temperature of a mixture of at least two types of phthalocyanine separated by mixing the phthalocyanine separation solvent and each of at least two types of phthalocyanine solution resulting from dissolving each of the at least two types of phthalocyanine starting material in a solvent.

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Номер записи: 29
31-10-2013 дата публикации

IONIC FLUIDS

Номер: US20130288886A1
Автор: ADURI Pavan Kumar, RATNAPARKHI Uday, SAKHALKAR Mangesh, Uppara Parasuveera
Принадлежит: RELIANCE INDUSTRIES LTD.

A method for preparing an ionic compound by mixing at least one compound of formula CA-zHO (1) with at least one hydrogen donor and heating the mixture obtained is provided. The said ionic compound remains in a physical state selected from the group consisting of liquid and semisolid at a temperature below 150° C., preferably below 125° C. 19.-. (canceled)10. A process for preparation of an ionic compound that remains in a physical state selected from the group consisting of liquid and semisolid , at a temperature below 150° C. , preferably below 125° C. , comprising mixing at least one compound of Formula CA.zHO (I) with at least one hydrogen donor and heating the resulting mixture to obtain an ionic compound;wherein, C is independently selected from the group consisting of Na, K, Li, Mg, Ca, Cr, Mn, Fe, Co, Mo, Ni, Cu, Zn, Cd, Sn, Pb, St, Bi, La, Ce, Al, Hg, Cs, Rb, Sr, V, Pd, Zr, Au, Pt, quaternary ammonium, immidazolium, phosphonium, and pyridinium, pyrrolidinium;{'sub': 3', '4', '3', '2', '4, 'A is independently selected from the group consisting of Cl, Br, F, I, NO, SO, CHCOO, HCOO and CO; and'}z is 0 to 20.11. The process as claimed in claim 10 , wherein the hydrogen donor is at least one selected from the group consisting of toluene-4-sulphonic acid monohydrate claim 10 , oxalic acid claim 10 , maleic acid claim 10 , citric acid and methane sulfonic acid.12. The process as claimed in claim 10 , wherein the mixture is heated to up to 150° C.13. A process as claimed in claim 10 , further comprising the method step of dissolving the ionic compound in at least one solvent selected from the group consisting of carboxylic acids claim 10 , amides claim 10 , alcohols claim 10 , amines claim 10 , ketones (aldehydes) claim 10 , esters claim 10 , alkyl halides claim 10 , ethers claim 10 , aromatics for example; methanol claim 10 , ethanol claim 10 , propan-1-ol claim 10 , propan-2-ol claim 10 , 1-butanol claim 10 , isobutanol claim 10 , 2-butanol claim 10 , tert- ...

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Номер записи: 30
05-12-2013 дата публикации

PHARMACEUTICAL COMPOSITION CONTAINING CYCLOMETALATED N-HETEROCYCLIC CARBENE COMPLEXES FOR CANCER TREATMENT

Номер: US20130324511A1
Автор: CHE Chi Ming, Chow Lok Fung, Sun Raymond Wai-Yin, Yan Jing
Принадлежит: The University of Hong Kong

The present disclosure is related to a pharmaceutical composition for treatment of cancer comprising a cyclometalated N-heterocyclic carbene complex. The cyclometalated N-heterocyclic carbene complex contains a gold(III) or a platinum(II) atom. The pharmaceutical composition possesses anti-cancer activity such as the induction of cell death, inhibition of cellular proliferation, inhibition of topoisomerase and/or poisoning of topoisomerase. 2. The method of claim 1 , comprising administering an effective amount of a pharmaceutical composition having the formula (I) claim 1 , wherein claim 1 ,{'sup': '3+', 'M is Au;'}X is a carbon atom;{'sup': 1', '2', '3', '4', '5, 'R, R, R, R, and Rare each —H;'}{'sup': 6', '7, 'sub': '3', 'Rand Rare each —CH;'}{'sub': 2', '3, 'A is a OSOCFanion;'}n is +1;b is −1; andy is 1 (complex 1).10. The method of claim 1 , comprising administering an effective amount of a pharmaceutical composition having the formula (I) claim 1 , wherein claim 1 ,{'sup': '2+', 'M is Pt;'}X is a nitrogen atom;{'sup': 1', '2', '3', '4', '5, 'R, R, R, R, and Rare each —H;'}{'sup': 6', '7, 'sub': '3', 'Rand Rare each —CH;'}{'sub': '6', 'A is a PFanion;'}n is +1;b is −1; andy is 1 (complex 11).11. The method of claim 1 , comprising administering an effective amount of a pharmaceutical composition having the formula (I) claim 1 , wherein claim 1 ,{'sup': '2+', 'M is Pt;'}X is a nitrogen atom;{'sup': 1', '2', '3', '4', '5, 'R, R, R, R, and Rare each —H;'}{'sup': 6', '7, 'sub': 2', '5, 'Rand Rare each —CH;'}{'sub': '6', 'A is a PFanion;'}n is +1;b is −1; andy is 1 (complex 12).12. The method of claim 1 , comprising administering an effective amount of a pharmaceutical composition having the formula (I) claim 1 , wherein claim 1 ,{'sup': '2+', 'M is Pt;'}X is a nitrogen atom;{'sup': 1', '2', '3', '4', '5, 'R, R, R, R, and Rare each —H;'}{'sup': 6', '7, 'sub': 3', '7, 'Rand Rare each —CH;'}{'sub': '6', 'A is a PFanion;'}n is +1;b is −1; andy is 1 (complex 13).13. The ...

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Номер записи: 31
05-12-2013 дата публикации

TREATING MYCOBACTERIAL INFECTION WITH CU+/++ BOOSTING THERAPEUTICS

Номер: US20130324598A1
Автор: Kutsch Olaf, Wolschendorf Frank
Принадлежит: THE UAB RESEARCH FOUNDATION

Provided herein are methods of treating a subject with a mycobacterial infection. The methods comprise administering to the subject a Cu boosting therapeutic. Also provided are compositions comprising a Cu boosting therapeutic. Further provided are methods of screening for a Cu boosting therapeutic. 1. A method of treating a subject with a mycobacterial infection , the method comprising administering to the subject a Cu boosting therapeutic.2. The method of claim 1 , wherein the Cu boosting therapeutic is selected from the group consisting of a therapeutic pre-complexed with Cu; a therapeutic capable of complexing Cu from tissue claim 1 , blood claim 1 , or intracellular compartments; and a therapeutic that interferes with Cu homeostatsis without complexing Cu.3. The method of claim 2 , wherein the Cu boosting therapeutic is a therapeutic pre-complexed with Cu.5. The method of claim 4 , wherein R claim 4 , R claim 4 , R claim 4 , R claim 4 , R claim 4 , and Rare each independently selected from hydrogen and substituted or unsubstituted C-Calkyl.6. The method of claim 4 , wherein Rand Rare hydrogen.7. The method of claim 4 , wherein R claim 4 , R claim 4 , R claim 4 , and Rare each independently selected from hydrogen and methyl.11. The method of claim 3 , wherein the Cu boosting therapeutic is disulfiram pre-complexed with Cu.13. The method of claim 1 , further comprising administering to the subject a supplement capable of increasing Cu availability.14. The method of claim 1 , wherein the mycobacterial infection is the result of an infection by a bacteria from the Mycobacteriaceae family.15. A composition comprising a Cu boosting therapeutic.16. The composition of claim 15 , wherein the Cu+/++ boosting therapeutic is selected from the group consisting of a therapeutic pre-complexed with Cu; a therapeutic capable of complexing Cu from tissue claim 15 , blood claim 15 , or intracellular compartments; and a therapeutic that interferes with Cu homeostatsis without ...

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Номер записи: 32
02-01-2014 дата публикации

Metal-organic framework materials with ultrahigh surface areas

Номер: US20140005428A1
Автор: Bhaskarjyoti Borah, Christopher E. Wilmer, Diego A. Gomez-Gualdron, Ibrahim ERYAZICI, Joseph T. Hupp, Omar K. Farha, Randall Q. Snurr
Принадлежит: Northwestern University

A metal organic framework (MOF) material including a Brunauer-Emmett-Teller (BET) surface area greater than 7,010 m 2 /g. Also a metal organic framework (MOF) material including hexa-carboxylated linkers including alkyne bond. Also a metal organic framework (MOF) material including three types of cuboctahedron cages fused to provide continuous channels. Also a method of making a metal organic framework (MOF) material including saponifying hexaester precursors having alkyne bonds to form a plurality of hexa-carboxylated linkers including alkyne bonds and performing a solvothermal reaction with the plurality of hexa-carboxylated linkers and one or more metal containing compounds to form the MOF material.

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Номер записи: 33
09-01-2014 дата публикации

Transition metal complexes of a bis[thiohydrazide amide] compound

Номер: US20140011864A1
Автор: Jianhua Shen, Masazumi Nagai
Принадлежит: Individual

The present invention is directed to a compound comprising a bis[thiohydrazide amide] or a deprotonated form thereof, complexed to a transition metal cation, wherein the bis[thiohydrazide amide] is represented by Structural Formula (I): or a prodrug, isomer, ester, salt, hydrate, solvate, polymorph or a deprotonated form thereof. The present invention also provides a pharmaceutical composition comprising a compound of the invention and method of use thereof.

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Номер записи: 34
23-01-2014 дата публикации

Process For The Preparation Of A Sulfated Derivative Of 3,5-Diiodo-O-[3-Iodophenyl]-L-Tyrosine

Номер: US20140024717A1
Автор: ANELLI Pier Lucio, Argese Maria, BOI Valeria, CAVALIERI Livio, Galimberti Laura, Gazzetto Sonia, Lattuada Luciano, MAISANO Federico, RIVOLTA Giovanni, VELLA Fulvia
Принадлежит: BRACCO IMAGING S.P.A.

The present invention relates to a process for the preparation of the mono sodium salt of the derivative 3,5-diiodo-O-[3-iodo-4-(sulphooxy)phenyl]-L-tyrosine (T3S) by starting from the corresponding phenolic compound, in the presence of chloro-sulfonic acid and dimethylacetamide as a solvent. The so obtained T3S compound may conveniently be isolated in a pure form as a solid in good yields. The present invention further relates to the process for T3S preparation, wherein the starting reagent is T2 and further comprising the formulation of such compound in tablets. Furthermore, the invention discloses non-radioactive immunoassays based on T3S derivatives. 2. The process according to claim 1 , wherein said inorganic salt is a sodium salt.3. The process according to claim 1 , wherein the molar ratio between CSA and the compound of formula I is comprised from 4 to 10.4. The process according to claim 1 , wherein in step a) the concentration of the compound of formula I in DMAC is comprised from 0.060 to 0.090 mol/L of DMAC.5. The process according to claim 1 , wherein the sulfation reaction in step a) is carried out at a temperature below 10° C.6. The process according to claim 5 , wherein the sulfation in step a) is left to occur for at least 2 hours.7. The process according to claim 1 , wherein the salification according to step b) is carried out in an aqueous solution of NaHCO.8. The process according to claim 1 , wherein step c) is preceded by a filtration step.9. The process according to claim 1 , wherein said decreasing polarity mixture is a mixture of water and a polar solvent in a ratio comprised from 1.0:0 to 0.7:0.3.109. The process according to any one of - claims 8 , wherein after elution claims 8 , the solution is concentrated to at least 10 g of Formula II compound/kg claims 8 , and the solution is brought to pH values comprised from 5.5 to 6.5.11. The process according to claim 1 , wherein the compound of formula II is obtained as a solid after treatment ...

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Номер записи: 35
06-02-2014 дата публикации

Method for Producing Amino Acid Chelate Compounds, Amino Acid Chelate Compounds and Use of Amino Acid Chelate Compounds

Номер: US20140037960A1
Автор: Gock Eberhard, Mathies Edmund, Ramhold Dietmar, Strauch Wolfram
Принадлежит: ISF GMBH

A method for producing amino acid chelate compounds, characterized in that metal oxides and/or metal carbonates and/or metal sulfates and/or metal chlorides and/or metal hydroxides in solid form are activated mechanically and then the activated metal oxides and/or metal carbonates and/or metal hydroxides and/or metal sulfates and/or metal chlorides are brought together with amino acids in solid form and converted to amino acid chelate compounds in a solid-state reaction. 1. A method for producing amino acid chelate compounds , whereinmetal oxides and/or metal carbonates and/or metal sulfates and/or metal chlorides and/or metal hydroxides in solid form are activated mechanically and then the activated metal oxides and/or metal carbonates and/or metal hydroxides and/or metal sulfates and/or metal chlorides are brought together with amino acids in solid form and converted to amino acid chelate compounds in a solid-state reaction.2. The method according to claim 1 , in which at least one reactant is thermally activated.3. The method according to claim 2 , in which the thermal activation takes place at the same time as the mechanical activation and/or in which the thermal activation takes place at the same time as the conversion.4. The method according to claim 1 , in which water created during the conversion is separated from the reactants.5. The method according to claim 4 , in which the water is separated by evaporation from the reactants.6. The method according to claim 1 , in which the raw materials are added dry.7. The method according to claim 1 , in which the metal compounds are added as a mixture of loose particles and/or amino acids as a mixture of loose particles.8. The method according to claim 1 , in which the activation and the conversion are executed in the same reactor.9. The method according to claim 1 , in which the activation and the conversion are executed in different reactors.10. The method according to claim 1 , in which the activation and/or the ...

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Номер записи: 36
06-02-2014 дата публикации

COLOR MATERIAL AND METHOD FOR PRODUCING THE SAME

Номер: US20140039201A1
Автор: Kinoshita Satoshi, Okada Masato
Принадлежит:

Color materials represented by the following general formula (I): 2. The color material according to claim 1 , wherein the anion (B) in the general formula (I) is an organic anion having a sulfonato group (—SO group).4. The color material according to claim 1 , wherein the anion (B) in the general formula (I) is an anion of an inorganic acid containing molybdenum and/or tungsten.5. The color material according to claim 1 , wherein “a” in the general formula (I) is 4 or less.6. The color material according to claim 1 , wherein the color material is a color material for being dispersed in a solvent having a solubility of the color material of 0.1 (mg/10 g solvent) or less at 23° C. The present invention relates to a novel color material with excellent heat resistance particularly, and a method for producing the same.Nowadays, a large number of dyes are known, and they are largely categorized into natural dyes and synthetic dyes. Examples of the synthetic dyes include aniline blue, fuchsine and methyl orange. Most of the synthetic dyes have an aromatic or heterocyclic ring, and they are classified as either ionic compounds (for example, all water-soluble dyes) or non-ionic compounds (for example, disperse dyes). In addition, in the case of the ionic dyes, they are categorized into anionic (negative ionic) dyes and cationic (positive ionic) dyes.The cationic dyes comprise an organic cation having a positive charge delocalized over a conjugated bond and normally an inorganic anion. Also, the cationic dyes are generally dyes in which an amino group which may have a substituent is involved in resonance. Therefore, selection of the cationic dyes depends on the number and kinds of the anion being a counter ion. Examples of the counter anion include a chloride ion, a bromide ion, an iodide ion, a perchlorate ion, a tetrafluoroborate ion, a hexafluorophosphate ion, an alkyl or aryl sulfate ion, a tosilate ion, an acetate ion and an oxalate ion.Generally, rhodamine, safranine ...

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Номер записи: 37
20-03-2014 дата публикации

NOVEL CONTRAST AGENTS

Номер: US20140081009A1
Автор: De Leon-Rodriguez Luis M.
Принадлежит:

This invention includes agents and compositions having MRI, PET, CT, X-ray, SPECT or optical signals, and methods for their use in the determination of a target. In some cases, a MRI, PET, CT, X-ray, SPECT, optical or other signal produced by the agent or composition can be affected by the presence of the target. Examples of targets that can be determined by this invention include, but are not limited to zinc, copper, iron ions and other biological targets. Example of application for imaging in vivo includes the function of pancreas and other organs. 5. The agent or composition according to claim 1 , wherein the target is a metal ion or a macromolecular receptor.6. The agent or composition according to claim 1 , wherein the target is Zn or Cu.7. The agent or composition according to claim 2 , wherein the target is a metal ion or a macromolecular receptor.8. The agent or composition according to claim 2 , wherein the target is Zn or Cu.9. The agent or composition according to claim 3 , wherein the target is a metal ion or a macromolecular receptor.10. The agent or composition according to claim 3 , wherein the target is Zn or Cu.11. The agent or composition according to claim 4 , wherein the target is a metal ion or a macromolecular receptor.12. The agent or composition according to claim 4 , wherein the target is Zn or Cu. This application is a continuation of U.S. patent application Ser. No. 12/748,445, filed Mar. 28, 2010, which claims priority to U.S. Provisional Application No. 61/225,187 filed Jul. 13, 2009, the disclosures of which are herein incorporated by reference.The present invention relates in general to the field of chelating agents, a method for preparing chelating agents and methods of using chelating agents in diagnostic and therapeutic applications.Without limiting the scope of the invention, its background is described in connection with contrast agents that detect a target in vivo for instance Zinc.In one aspect, this invention relates to ...

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Номер записи: 38
27-03-2014 дата публикации

ZEOLITE POROUS METAL BIS(IMIDAZOLE) COORDINATION POLYMERS AND PREPARATION METHOD THEREOF

Номер: US20140088312A1
Автор: Li Dan, Liu Jie, ZHOU XIAOPING
Принадлежит:

The present invention discloses zeolite metal bis(imidazole) coordination polymers and preparation method thereof. The new class of zeolite coordination polymers of the present invention is a chemical compound with the following general chemical formula {[M(Blm)]×xDMF×yCHO×zHO}, in which when M=Zn, x=0.9, y=0, z=0; when M=Cu, x=1.2, y=0, z=0; when M=Mn, x=2.0, y=0, z=0; when M=Ni, x=0.4, y=1.2, z=1.0, Blm is 1,2-bis((5H-imidazol-4-yl)methylene)hydrazine, DMF is N,N-dimethyl formamide, HO is water. A solvothermal method or slow diffusion is used on the compounds to obtain crystals of high purity. The coordination polymers of the present invention have good thermal stability, and have strong adsorption performance for COunder conditions of 0° C. and normal pressure as adsorbent materials. 1. Zeolite porous metal bis(imidazole) coordination polymer having the following general chemical formula:{'br': None, 'i': x', 'y', 'z, 'sub': 2', '6', '2', '∞, '{[M(Blm)]×DMF×CHO×HO}, whereinM=Zn, x=0.9, y=0, z=0;M=Cu, x=1.2, y=0, z=0;M=Mn, x=2.0, y=0, z=0;M=Ni, x=0.4, y=1.2, z=1.0Blm is 1,2-bis((5H-imidazol-4-yl)methylene)hydrazine, DMF is N,N-dimethyl formamide.2. The porous coordination polymers according to claim 1 , wherein crystals of the zeolite porous metal bis(imidazole) coordination polymers belong to a cubic system claim 1 , space group is Ia d claim 1 , and cell parameter are:{'sup': '3', 'zinc 1,2-bis((5H-imidazol-4-yl)methylene)hydrazine: a=b=c=34.6471(2) Å, α=β=γ90°, V=41591.1(4) Å;'}{'sup': '3', 'copper-1,2-bis((5H-imidazol-4-yl)methylene)hydrazine: a=b=c=34.2896(3) Å, α=β=γ=90°, V=40316.8(6) Å;'}{'sup': '3', 'manganese-1,2-bis((5H-imidazol-4-yl)methylene)hydrazine: a=b=c=35.7950(4) Å, α=β=γ=90°, V=45863.4(9) Å;'}{'sup': '3', "nickel-1,2-bis((5H-imidazol-4-yl)methylene)hydrazine: a=b=c=33.8514(19), α=β=γ=90°, V=38791(4) Å; wherein metal atoms of the nickel-1,2-bis((5H-imidazol-4-yl)methylene)hydrazine adopt a six-coordinate octahedral configuration; and metal atoms ...

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Номер записи: 39
13-01-2022 дата публикации

CUPROUS CYSTEAMINE OPTICAL MATERIALS FOR VISIBLE LIGHT ENHANCEMENT

Номер: US20220009947A1
Автор: Chen Wei
Принадлежит:

Disclosed herein are composite materials that comprise one or more copper-cysteamines capable of converting higher frequency, lower wavelength radiation into visible light. As used, the produced visible light enhances the amount of visible light already present from natural or artificial sources. 1. A compound having the formula:{'br': None, 'sub': 3', '2, 'CuX(SR)'}{'sub': 2', '2', '2, 'wherein R is —CHCHNH; and'}X is chosen from Br, or I.2. The compound according to claim 1 , wherein X is Br.3. The compound according to claim 1 , wherein X is I.4. A composite claim 1 , comprising: i) a first copper-cysteamine that emits visible light in the range of from about 520 nm to about 700 nm when exposed to UV radiation; and', 'ii) a second copper-cysteamine that emits visible light in the range of from about 400 to about 520 nm when exposed to UV radiation; and, 'a) a visible light enhancing composition, comprisingb) a substrate; {'br': None, 'sub': 3', '2, 'CuX(SR)'}, 'wherein the copper-cysteamine has the formula{'sub': 2', '2', '2, 'wherein R is —CHCHNH; and'}X is chosen from Cl, Br, or I.5. The composite according to claim 4 , wherein the substrate is a polymer.6. The composite according to claim 4 , wherein the substrate is a polymer chosen from polystyrene claim 4 , polyethylene claim 4 , polyester claim 4 , polyvinyl chloride claim 4 , polystyrene claim 4 , or poly(methyl methacrylate).7. The composite according to claim 4 , wherein the substrate is transparent.8. The composite according to claim 4 , wherein the substrate is semi-transparent.9. The composite according to claim 4 , wherein the substrate has a first transparent surface and a second semi-transparent surface.10. The composite according to claim 4 , wherein the substrate is in the form of a film.11. The composite according to claim 4 , wherein the substrate is in the form of a geometric shape.12. A method for providing solid state lighting having enhanced visible light claim 4 , comprising; [ i) a first ...

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Номер записи: 40
20-01-2022 дата публикации

IGM COMPOSITIONS AND METHODS OF MUCOSAL DELIVERY OF THESE COMPOSITIONS

Номер: US20220017453A2
Автор: Gong Siqi, Ruprecht Ruth
Принадлежит:

Described herein are methods of inducing an immune response directed towards preventing or reducing the risk of a human immunodeficiency virus (HIV) infection in a mammalian subject. The subject is administered an effective amount of a composition containing IgM antibodies directed to an epitope of an envelope protein of the HIV virus. Also disclosed here are vaccine compositions comprising IgM antibodies directed to one or more epitopes of one or more human immunodeficiency virus envelope proteins. Also disclosed are recombinant immunoglobulin M compositions containing a Fcγ fragment of an immunoglobulin G. 1. A method of inducing an immune response directed towards preventing or reducing the risk of a human immunodeficiency virus (HIV) infection in a mammalian subject , comprisingadministering to the mammalian subject an effective amount of a composition containing immunoglobulin M (IgM) antibodies directed to an epitope of a human immunodeficiency virus envelope protein.2. The method of claim 1 , wherein the composition containing IgM antibodies is formulated for a mucosal administration.3. The method of claim 2 , wherein the mucosal layer is a rectal mucosal layer.4. The method of claim 1 , wherein the human immunodeficiency virus envelope protein is HIV-1 gp120.5. A recombinant immunoglobulin M composition claim 1 , comprising:a Fcγ fragment of an immunoglobulin G connected to a carboxy terminus of a joining chain of an immunoglobulin M.6. The recombinant immunoglobulin M composition of claim 5 , wherein the Fcγ fragment of the immunoglobulin G is connected to the carboxy terminus of the joining chain of the immunoglobulin M via a linker.7. The recombinant immunoglobulin M composition of claim 6 , wherein the linker is a glycine- and serine-rich linker.8. A recombinant immunoglobulin M composition claim 6 , comprising:a Fcγ fragment of an immunoglobulin G connected to a carboxy terminus of a constant region of a light chain of immunoglobulin M.9. The ...

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Номер записи: 41
14-01-2016 дата публикации

Ultrastable Silver Nanoparticles

Номер: US20160009736A1
Автор: BIGIONI Terry, CONN Brian, Desireddy Anil
Принадлежит: The University of Toledo

Ultrastable silver nanoparticles, methods of making the same, and methods of using the same, are disclosed. 1. A compound comprising the formula MAg(SR)wherein:M is a metal selected from the group consisting of Cs, Na, K, Li, Fr, and Rb; andSR is a mercaptophenyl ligand;and salts, isomers, stereoisomers, entantiomers, racemates, solvates, hydrates, polymorphs, and prodrugs thereof.2. The compound of claim 1 , wherein the mercaptophenyl ligand is selected from the group consisting of p-mercaptobenzoic acid claim 1 , p-mercaptophenyl alcohol claim 1 , and 4-mercaptophenol.3. (canceled)4. The compound of claim 1 , further comprising coordinating molecules selected from the group consisting of: deprotonated methanol ions claim 1 , deprotonated ethanol ions claim 1 , hydroxide ions claim 1 , citrate claim 1 , acetate claim 1 , DMSO claim 1 , DMF claim 1 , pyridine claim 1 , ammonia claim 1 , acetone claim 1 , acetonitrile claim 1 , ethers claim 1 , phosphines claim 1 , and combinations thereof.5. The compound of claim 4 , wherein the compound has a core comprising coordination sites claim 4 , and the coordinating molecules stabilize the compound by binding to the coordination sites.6. The compound of claim 5 , wherein one or more of the coordinating molecules is substituted by one or more of a pharmaceutical agent claim 5 , a fluorophore claim 5 , or a carbohydrate claim 5 , covalently bonded through a sulfur linkage at a coordination site.7. The compound of claim 1 , wherein the compound comprises a Agcore and a protecting layer of AgScapping structures.8. A silver cluster molecule comprising: a 32-silver-atom dodecahedral core consisting of a 12-silver-atom icosahedron encapsulated by a 20-silver-atom dodecahedron; and 30 coordinating ligands.9. The silver cluster molecule of claim 8 , wherein the coordinating ligands comprise p-MBA.10. The silver cluster molecule of claim 8 , wherein the dodecahedral core comprises icosahedral symmetry.11. The silver cluster molecule ...

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Номер записи: 42
11-01-2018 дата публикации

Gold nanoparticles and methods of making and using gold nanoparticles

Номер: US20180009829A1
Автор: Edward W. Elliott, III, James E. Hutchison, Patrick Haben, Zachary Kennedy
Принадлежит: University of Oregon

Disclosed herein are embodiments of gold nanoparticles and methods of making and using the gold nanoparticles. The disclosed gold nanoparticles have core sizes and polydispersities controlled by the methods of making the gold nanoparticles. In some embodiments, the methods of making the gold nanoparticles can concern using flow reactors and reaction conditions controlled to make gold nanoparticles having a desired core size. The gold nanoparticles disclosed herein also comprise various ligands that can be used to facilitate the use of the gold nanoparticles in a variety of applications.

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Номер записи: 43
08-01-2015 дата публикации

SURFACE MODIFICATION OF METAL NANOSTRUCTURES

Номер: US20150011763A1
Автор: Whitcomb David R.
Принадлежит:

A nanostructure comprising at least one metal nanowire comprising at least one surface, and at least one surface modifier disposed on the at least one surface, the at least one surface modifier comprising at least one linkage component, at least one nanowire binding moiety bonded to the at least one linkage component, and at least one surface modifying moiety also bonded to the at least one linkage component, where the at least one nanowire binding moiety is bonded to the at least one surface. 1. A nanostructure comprising:at least one metal nanowire comprising at least one surface, andat least one surface modifier disposed on the at least one surface, the at least one surface modifier comprising at least one linkage component, at least one nanowire binding moiety bonded to the at least one linkage component, and at least one surface modifying moiety also bonded to the at least one linkage component,wherein the at least one nanowire binding moiety is bonded to the at least one surface.2. The nanostructure of claim 1 , wherein the linkage component comprises a hydrocarbon claim 1 , an organometallic component claim 1 , a nonmetal claim 1 , or a neutral moiety.3. The nanostructure of claim 1 , wherein the linkage component does not comprise silicon.4. The nanostructure of claim 1 , wherein the nanowire binding moiety comprises sulfur claim 1 , nitrogen claim 1 , phosphorus claim 1 , or an ionic substance.5. The nanostructure of claim 1 , wherein the nanowire binding moiety comprises at least one fluorine atom.6. The nanostructure of claim 1 , wherein the nanowire binding moiety comprises carbon.7. The nanostructure of any of claim 1 , wherein the nanowire binding moiety binds to the at least one surface through a dipolar bond.8. The nanostructure of claim 1 , wherein the surface modifying moiety comprises an amine group claim 1 , an epoxy group claim 1 , a carboxylate group claim 1 , a trifluoromethyl group claim 1 , or a thiol group.9. The nanostructure of claim 1 , ...

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Номер записи: 44
14-01-2021 дата публикации

COMPOSITIONS AND METHODS COMPRISING CONDUCTIVE METAL ORGANIC FRAMEWORKS AND USES THEREOF

Номер: US20210009617A1
Автор: Campbell Michael Glenn, Dinca Mircea, Sheberla Dennis, Sun Lei, Wade Casey R.
Принадлежит: Massachusetts Institute of Technology

Compositions and methods comprising metal organic frameworks (MOFs) and related uses are generally provided. In some embodiments, a MOF comprises a plurality of metal ions, each coordinated with at least one ligand comprising at least two sets of ortho-diimine groups arranged about an organic core. 140-. (canceled)41. Use of a MOF as a conductive material , wherein the MOF comprises:a plurality of metal ions, each coordinated with at least one ligand comprising at least two sets of ortho-diimine groups arranged about an organic core.42. (canceled)43. Use of a MOF for chemical sensing , wherein the MOF comprises:a plurality of metal ions, each coordinated with at least one ligand comprising at least two sets of ortho-diimine groups arranged about an organic core.4445-. (canceled)46. The use of claim 41 , wherein a portion of the metal ions are associated with two claim 41 , three claim 41 , or four ligands claim 41 , and each of those ligands is individually associated with one claim 41 , two claim 41 , three claim 41 , or four metal ions.47. The use of claim 41 , wherein the at least two sets of ortho-diimine groups are least two sets of ortho-phenylenediimine groups.48. The use of claim 41 , wherein each metal ion is a monovalent claim 41 , divalent claim 41 , or trivalent metal ion.49. The use of claim 41 , wherein each metal ion is Ag claim 41 , Cu claim 41 , Au claim 41 , Mg claim 41 , Mn claim 41 , Fe claim 41 , Co claim 41 , Ni claim 41 , Cu claim 41 , Pd claim 41 , Pt claim 41 , Ru claim 41 , Cd claim 41 , Zn claim 41 , Pb claim 41 , Hg claim 41 , V claim 41 , Cr claim 41 , Ni claim 41 , Fe claim 41 , V claim 41 , Ti claim 41 , Sc claim 41 , Al claim 41 , In claim 41 , Ga claim 41 , Mn claim 41 , Co claim 41 , and/or Cr.50. The use of claim 41 , wherein the organic core comprises a plurality of fused aryl and/or heteroaryl rings.51. The use of claim 41 , wherein the organic core comprises one or more of benzyl claim 41 , thiophenyl claim 41 , carbazolyl claim ...

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Номер записи: 45
10-01-2019 дата публикации

Method of preparing luminescent nano-sheet, luminescent nano-sheet material, luminescent nano-sheet film, back light, and liquid crystal display apparatus

Номер: US20190010393A1
Автор: Haizheng Zhong, Lige Liu
Принадлежит: Beijing Institute of Technology BIT, BOE Technology Group Co Ltd

The present application discloses a method of preparing a luminescent nano-sheet. The method includes preparing a precursor emulsion solution containing a metal halide and RNH3X, and having a molar ratio of metal halide to RNH3X in a range of approximately 0.6 to approximately 0.8; demulsifying the precursor emulsion solution to obtain a perovskite quantum dots material and a demulsified solution; and forming the luminescent nano-sheet by allowing the perovskite quantum dots material self-assemble into the luminescent nano-sheet. X is a halide, R is selected from alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, cycloalkynyl, aryl, heteroaryl, and heterocyclyl.

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Номер записи: 46
09-01-2020 дата публикации

Biflavone-copper complex, preparation method and application thereof

Номер: US20200010483A1
Автор: LI Xu, Shilong Yang, Zhong Li
Принадлежит: NANJING FORESTRY UNIVERSITY

wherein, X is NO3− or Cl−. A method of preparing the biflavone-copper complex includes the following steps: dissolving a copper salt in an alcohol and then adding into a biflavone alcoholic solution, controlling pH to 5-7; under heating and stirring, performing a reaction for 2-5 h to form a precipitate; filtering the precipitate, washing the precipitate with alcohol and water, recrystallizing the precipitate using dimethyl sulfoxide as a solvent, and drying the precipitate to obtain the biflavone-copper complex. The biflavone-copper complex is used for preparing an antitumor drug and/or an antioxidant drug.

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Номер записи: 47
12-01-2017 дата публикации

MATERIALS FOR ORGANIC ELECTROLUMINESCENT DEVICES

Номер: US20170012221A1
Автор: Buesing Arne, Heil Holger, Martynova Irina, Mujica-Fernaud Teresa
Принадлежит:

The present invention relates to coordination compounds which are used in an electron-transport layer in electronic devices, to ligands, and to the use thereof for the preparation of metal complexes, to a layer, and to an electronic device which comprise the compounds according to the invention, and to a process for the preparation of the compounds according to the invention. 116-. (canceled)18. The compound according to claim 17 , wherein the following applies to compounds of the formula (I):if M is a metal having two coordination sites, then k is equal to 0;if M is a metal having three coordination sites and L′ is a monodentate ligand, then k is equal to 1;if M is a metal having four coordination sites and L′ is a monodentate ligand, then k is equal to 2;if M is a metal having five coordination sites and L′ is a monodentate ligand, then k is equal to 3;if M is a metal having six coordination sites and L′ is a monodentate ligand, then k is equal to 4;if M is a metal having seven coordination sites and L′ is a monodentate ligand, then k is equal to 5;if M is a metal having eight coordination sites and L′ is a monodentate ligand, then k is equal to 6;if M is a metal having four coordination sites and L′ is a bidentate ligand, then k is equal to 1;if M is a metal having six coordination sites and L′ is a bidentate ligand, then k is equal to 2;if M is a metal having eight coordination sites and L′ is a bidentate ligand, then k is equal to 3;and wherein the following applies to compounds of the formula (II):if M is a metal having two coordination sites and r is equal to i, then l is equal to 0;if M is a metal having three coordination sites, L′ is a monodentate ligand and r is equal to 1, then l is equal to 1;if M is a metal having four coordination sites, L′ is a monodentate ligand and r is equal to 1, then l is equal to 2;if M is a metal having five coordination sites, L′ is a monodentate ligand and r is equal to 1, then l is equal to 3;if M is a metal having six ...

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Номер записи: 48
09-01-2020 дата публикации

FLOW BATTERIES INCORPORATING A NITROXIDE COMPOUND WITHIN AN AQUEOUS ELECTROLYTE SOLUTION

Номер: US20200014054A1
Автор: Humbarger Scott Thomas, MILLARD Matthew, NELSON Emily Grace, Norman Zachariah M.
Принадлежит:

Flow batteries can include a first half-cell containing a first aqueous electrolyte solution, a second half-cell containing a second aqueous electrolyte solution, and a separator disposed between the first half-cell and the second half-cell. The first aqueous electrolyte solution contains a first redox-active material, and the second aqueous electrolyte solution contains a second redox-active material. At least one of the first redox-active material and the second redox-active material is a nitroxide compound or a salt thereof. Particular nitroxide compounds can include a doubly bonded oxygen contained in a ring bearing the nitroxide group, a doubly bonded oxygen appended to a ring bearing the nitroxide group, sulfate or phosphate groups appended to a ring bearing the nitroxide group, various heterocyclic rings bearing the nitroxide group, or acyclic nitroxide compounds. 2. The flow battery of claim 1 , wherein each Ris H claim 1 , and R-Rare each methyl.3. The flow battery of claim 1 , wherein Ais of S(═O) claim 1 , S(═O) claim 1 , P(═O)R claim 1 , or P(═O)OR.4. The flow battery of claim 3 , wherein Ais S(═O).6. The flow battery of claim 5 , wherein each Ris H claim 5 , and R-Rare each methyl.7. The flow battery of claim 5 , wherein Ais S(═O)OH claim 5 , S(═O)R claim 5 , S(═O)R claim 5 , S(═O)NRR claim 5 , OS(═O)OR claim 5 , NRC(═O)NRR claim 5 , NRC(═S)NRR claim 5 , or NRS(═O)R.8. The flow battery of claim 7 , wherein Ais S(═O)NRRor NRC(═S)NRR claim 7 , and at least one Rbound to N is H.9. The flow battery of claim 7 , wherein Ais OS(═O)OR.10. The flow battery of claim 9 , wherein Ris H.11. A flow battery comprising:a first half-cell containing a first aqueous electrolyte solution;a second half-cell containing a second aqueous electrolyte solution; anda separator disposed between the first half-cell and the second half-cell;wherein at least one of the first redox-active material and the second redox-active material comprises a nitroxide compound or a salt thereof ...

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Номер записи: 49
03-02-2022 дата публикации

METAL ORGANIC FRAMEWORKS AND METHODS OF PREPARATION THEREOF

Номер: US20220033425A1
Автор: AHMED Heba Adel Aly ElSayed ElSayed, Rezk Amgad Rezk Noshi, RICHARDSON Joseph J., YEO Leslie Yu-Ming
Принадлежит:

A method of preparing a Metal Organic Framework (MOF) with an acoustically-driven microfluidic platform, the method comprising: depositing a liquid comprising MOF precursors on a piezoelectric substrate of an acoustic microfluidic platform, the MOF precursors comprising a metal ion and an organic ligand, applying acoustic irradiation to the liquid to induce azimuthal liquid recirculation, which causes formation of the MOF within the liquid, and isolating the MOF. 1. A method of preparing a Metal Organic Framework (MOF) with an acoustically-driven microfluidic platform , the method comprising:depositing a liquid comprising MOF precursors on a piezoelectric substrate of an acoustic microfluidic platform, the MOF precursors comprising a metal ion and an organic ligand,applying acoustic irradiation to the liquid to induce azimuthal liquid recirculation, which causes formation of the MOF within the liquid, andisolating the MOF.2. A method according to wherein the MOF is at least a partially activated MOF.3. A method according to wherein the MOF is an activated MOF.4. A method according to wherein the MOF has a high degree of orientation.5. A method according to wherein the acoustic irradiation comprises surface acoustic waves claim 1 , bulk acoustic waves or hybrid acoustic waves comprising both surface and bulk acoustic waves.6. A method according to wherein the surface acoustic waves are Rayleigh surface acoustic waves or shear-horizontal surface acoustic waves.7. A method according to wherein the acoustic irradiation comprises travelling or standing acoustic waves.8. A method according to wherein the azimuthal liquid recirculation is induced by off-centre acoustic waves.9. A method according to wherein the acoustic platform comprises at least one interdigitated transducer (IDT) positioned off-centred relative to the liquid comprising MOF precursors to generate off-centre acoustic waves.10. A method according to wherein the acoustic platform comprises two opposing off- ...

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Номер записи: 50
09-01-2020 дата публикации

NONAQUEOUS ELECTROLYTE SECONDARY BATTERY

Номер: US20200014066A1
Автор: Iwai Mitsuru, Shiraga Masahiro, Zhong Yuanlong
Принадлежит: Panasonic Intellectual Property Management Co., Ltd.

This non-aqueous electrolyte secondary battery is provided with a positive electrode, a negative electrode and a non-aqueous electrolyte. The non-aqueous electrolyte contains: a non-aqueous solvent that contains a fluorine-containing cyclic carbonate; a cyclic carboxylic acid anhydride such as diglycolic acid anhydride; and an imide lithium salt having a sulfonyl group such as lithium bis(fluorosulfonyl)imide. 2. The non-aqueous electrolyte secondary battery according to claim 1 , wherein the cyclic carboxylic anhydride contains at least one of diglycolic anhydride claim 1 , methyldiglycolic anhydride claim 1 , dimethyldiglycolic anhydride claim 1 , ethyldiglycolic anhydride claim 1 , vinyldiglycolic anhydride claim 1 , allyldiglycolic anhydride claim 1 , and divinyldiglycolic anhydride.3. The non-aqueous electrolyte secondary battery according to claim 1 , wherein the imide lithium salt having sulfonyl groups contains at least one of lithium bis(fluorosulfonyl)imide claim 1 , lithium bis(trifluoromethanesulfonyl)imide claim 1 , lithium bis(pentafluoroethanesulfonyl)imide claim 1 , and lithium bis(nonafluorobutanesulfonyl)imide.4. The non-aqueous electrolyte secondary battery according to claim 1 , wherein the content of the fluorine-containing cyclic carbonate in the non-aqueous solvent is 5 vol % or more and 50 vol % or less.5. The non-aqueous electrolyte secondary battery according to claim 1 , wherein the content of the cyclic carboxylic anhydride in the non-aqueous electrolyte is 0.1 mass % or more and 1.5 mass % or less claim 1 , and the content of the imide lithium salt having sulfonyl groups in the non-aqueous electrolyte is 0.1 mass % or more and 1.5 mass % or less. The present invention relates to a technique concerning a non-aqueous electrolyte secondary battery.In recent years, a non-aqueous electrolyte secondary battery which includes a positive electrode, a negative electrode, and a non-aqueous electrolyte, and achieves charge and discharge by moving ...

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Номер записи: 51
18-01-2018 дата публикации

USE OF METAL-ACCUMULATING PLANTS FOR THE PREPARATION OF CATALYSTS THAT CAN BE USED IN CHEMICAL REACTIONS

Номер: US20180015317A1
Автор: ESCARRE Jose, GRISON Claude
Принадлежит:

A method of implementing organic synthesis reactions uses a composition containing a metal catalyst originating from a calcined plant. The plants can be from the Brassicaceae, Sapotaceae and Convolvulaceae family, and the metal catalyst contains metal in the M(II) form such as zinc, nickel, manganese, lead, cadmium, calcium, magnesium or copper. Examples of the organic synthesis reactions include halogenations, electrophilic reactions, cycloadditions, transesterification reactions and coupling reactions, among others. 1. A method for the implementation of an organic synthesis reaction , comprising: [{'sup': 2+', '2+', '3+', '+', '+, 'wherein said at least one metal in the M(II) form is selected from the group consisting of zinc (Zn), nickel (Ni), and manganese (Mn), said metal in the M(II) form having been accumulated by the plant during its growth in a soil containing said metal and at least one cationic species selected from the group consisting of MgCa, Fe, Na and K which have not been accumulated by said plant but are physiologically present in said plant and originate from the latter; and'}, 'bringing the composition into contact with at least one chemical compound capable of reacting with said composition., 'providing a composition comprising at least one metal catalyst containing a metal in the M(II) form, said metal originating from a calcined plant or calcined plant part, said composition having been acid treated,'}2. The method according to claim 1 , wherein the organic synthesis reaction is selected from halogenations claim 1 , electrophilic aromatic reactions in series claim 1 , synthesis of 3 claim 1 ,4-dihydropyrimidin-2(1H)-one or 3 claim 1 ,4-dihydropyrimidin-2(1H)-thione claim 1 , cycloaddition reactions claim 1 , transesterification reactions claim 1 , catalyst synthesis reactions for coupling or hydrogenation reactions after reduction of Ni(II) to Ni(0) claim 1 , synthesis of amino acid or oxime developers claim 1 , and hydrolysis of sulphur- ...

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Номер записи: 52
21-01-2016 дата публикации

FORWARD OSMOSIS SYSTEM USING COORDINATION COMPLEXES

Номер: US20160016116A1
Автор: Chung Tai-shung, Cui Yue, Ge Qingchun, Su Jincai
Принадлежит: NATIONAL UNIVERSITY OF SINGAPORE

A forward osmosis system. The system contains a forward osmosis membrane, a draw solution, and a feed solution. The draw solution includes a coordination complex formed of a metal ion and an organic ligand coordinated to the metal ion. Also disclosed are a method of separating a liquid using such a forward osmosis system and a coordination complex used in this system.

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Номер записи: 53
21-01-2016 дата публикации

GOLD COMPLEXES

Номер: US20160016976A2
Автор: NOLAN Steven P.
Принадлежит: UNIVERSITY COURT OF THE UNIVERSITY OF ST ANDREWS

Gold (I) hydroxide complexes of the form Z—Au—OH and digold complexes of the form Z—Au-(μOH)—Au—Z where groups Z are two electron donors are provided. The groups Z may be carbenes, for example nitrogen containing heterocyclic carbenes (NHCs), phosphines or phosphites. The complexes can be used as catalysts, for example in reactions such as hydration of nitriles, skeletal arrangement of enynes, alkoxycyclisation of enynes, alkyne hydration, the Meyer-Shuster reaction, 3,3′ rearrangement of allylic acetates, cyclisation of propargylic acetates, Beckman rearrangements and hydroamination. The complexes can be used in medicine, for example in the treatment of cancer. 2. The method according to wherein the complex is used as a catalyst claim 1 , or for the in situ production of a catalyst claim 1 , for catalyzing a chemical transformation of the substrate claim 1 , the chemical transformation selected from the group consisting of: hydration of nitriles claim 1 , skeletal arrangement of enynes claim 1 , alkoxycyclisation of enynes claim 1 , alkyne hydration claim 1 , the Meyer-Shuster reaction claim 1 , 3 claim 1 ,3′ rearrangement of allylic acetates claim 1 , cyclisation of propargylic acetates claim 1 , Beckman rearrangements and hydroamination.3. (canceled)4. (canceled)5. The method according to wherein the complex is according to general formula V and the anion A is selected from the group consisting of BF claim 1 , PF claim 1 , SbF claim 1 , [B{CH(CF)}] claim 1 , and [B(CF)].6. The method according to wherein the groups Z are selected from the group consisting of carbene claim 1 , phosphine claim 1 , and phosphite two-electron donor ligands.7. The method according to wherein the groups Z are selected from the group consisting of cyclic or acyclic carbenes having one or more heteroatoms claim 6 , triphenylphosphine claim 6 , substituted triphenylphenylphosphine claim 6 , substituted triphenylphosphite claim 6 , and substituted triphenyl phosphite.8. The method ...

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Номер записи: 54
21-01-2021 дата публикации

METHOD FOR MANUFACTURING NOVEL NITROGEN-CONTAINING COMPOUND OR SALT THEREOF AND MANUFACTURING INTERMEDIATE OF NOVEL NITROGEN-CONTAINING COMPOUND OR SALT THEREOF

Номер: US20210015802A1
Автор: FUKUNAGA Hirofumi, Nakagawa Daisuke, SEKINE Shinichiro, SHINJO Sachiko, YAMAKAWA Takayuki
Принадлежит: FUJIFILM Corporation

A compound represented by Formula [3] or a salt thereof and a method of making the same, 2. The compound according to or a salt thereof claim 1 ,{'sup': '7', 'sub': '1-6', 'wherein Ris a Calkyl group which can be substituted or a benzyl group which can be substituted.'} This application is a Divisional of U.S. application Ser. No. 15/712,815, filed Sep. 22, 2017, which is a Continuation of National Phase of PCT International Application PCT/JP2016/059729 filed on Mar. 25, 2016, which claims priority under 35 U.S.C 119(a) to Japanese Patent Application No. 2015-062306 filed on Mar. 25, 2015. Each of the above application(s) is hereby expressly incorporated by reference, in its entirety, into the present application.The present invention relates to a method for manufacturing a novel nitrogen-containing compound or a salt thereof and a manufacturing intermediate of the compound or a salt thereof.Integrins are a kind of cell adhesion receptors which constitute a family of heterodimeric glycoprotein complexes formed of α and β subunits and are mainly involved in the cell adhesion to extracellular matrix and the transmission of information from extracellular matrix.Among the integrins, integrins ανβand ανβwhich are vitronectin receptors are known to be expressed at a low level on epithelial cells or matured endothelial cells while hyper-expressed in various tumor cells or new blood vessels. The hyper-expression of integrins ανβand ανβis considered to be involved in the exacerbation of cancer such as infiltration or metastasis accompanying tumor angiogenesis and be highly correlated to the malignancy (Nature Reviews cancer, Vol. 10, pp. 9˜23, 2010). It has been revealed that the hyper-expression of integrin is observed in cancer such as head and neck cancer, colorectal cancer, breast cancer, small cell lung cancer, non-small cell lung cancer, glioblastoma, malignant melanoma, pancreatic cancer, and prostatic cancer (Clin. Cancer Res. Vol. 12, pp. 3942˜3949, 2006). ...

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Номер записи: 55
17-04-2014 дата публикации

Nitrogen-Containing Ligands And Their Use In Atomic Layer Deposition Methods

Номер: US20140102365A1
Автор: Anthis Jeffrey W., Thompson David
Принадлежит:

Methods for deposition of elemental metal films on surfaces using metal coordination complexes comprising nitrogen-containing ligands are provided. Also provided are nitrogen-containing ligands useful in the methods of the invention and metal coordination complexes comprising these ligands. 1. A metal coordinating ligand having a formula{'sub': 1', '2', 'x', 'y', '7', '8', '1-6', '2-4', '1', '2', '7', '8', '3', '4', '5', '6, 'a) RRN—(CR)—N—(CR)—NRR, wherein each R is independently hydrogen, Calkyl, acyl, aldehyde, keto or Calkenyl and x and y are independently 2-6, provided that when each of R, R, Rand Ris ethyl, at least one of R, R, Rand Ris not H;'}{'sub': 1', '2', '1', '2', '3', '4', '1-6', '2-4', '1', '2', '1', '2', '3', '4, 'b) RRN—Ar—NH—Ar—NRR, wherein each R is independently hydrogen, Calkyl, acyl, aldehyde, keto or Calkenyl, and Arand Arare aromatic hydrocarbon moieties which may be the same or different, provided that at least one of R, R, Rand Ris not methyl;'}{'sub': 1', '2', '3', '4', 'x', 'Ar', '5', '6', 'y', '7', '8', '1-6', '2-4', 'Ar', '1', '2', '3', '4, 'c) RRN—(CRR)—N—(CRR)—NRR, wherein each R is independently hydrogen, Calkyl, acyl, aldehyde, keto or Calkenyl, and Nis a heterocyclic aromatic moiety wherein the heteroatom is N, provided that at least one of R, R, Rand Ris not methyl, or;'}{'sub': Ar1', '1', '2', 'x', '5', '3', '4', 'y', 'Ar2', '1-6', '2-4', 'Ar1', 'Ar2, 'd) N—(CRR)—NR—(CRR)—N, wherein each R is independently hydrogen, Calkyl, acyl, aldehyde, keto or Calkenyl, and Nand Nmay be the same or different and are heterocyclic aromatic moieties wherein the heteroatom is N.'}3. The metal coordinating ligand of claim 2 , wherein R claim 2 , R claim 2 , Rand Rof formula I are each ethyl (Et) and each of R-Ris independently hydrogen claim 2 , Calkyl claim 2 , acyl claim 2 , aldehyde claim 2 , keto or Calkenyl.4. An apparatus comprising:a deposition chamber; and{'claim-ref': {'@idref': 'CLM-00001', 'claim 1'}, 'the metal coordinating ligand of ...

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Номер записи: 56
28-01-2016 дата публикации

COPPER (I) COMPLEXES WITH GLYCINE, PYRUVATE, AND SUCCINATE

Номер: US20160024118A1
Автор: Barker Charles Louis Albartus, Boulanger William A.
Принадлежит:

The present invention is directed to a pharmaceutical and/or dietary supplement composition comprising an effective amount of a copper (I) complex with glycine, pyruvate, or succinate and methods of treating mitochondrial, neuromuscular, and other diseases. Also provided are pharmaceutical treatment regimes and kits comprising a copper (I) complex with glycine, pyruvate, or succinate. 43. The composition of any of - claims 1 , wherein the pharmaceutically acceptable carrier is an inert diluent and/or an extended release formulation.54. The composition of any of - claims 1 , further comprising a delivery vehicle selected from a liposome claims 1 , a microsome claims 1 , a nanosome claims 1 , a picosome claims 1 , a pellet claims 1 , a granular matrix claims 1 , a bead claims 1 , a microsphere claims 1 , a nanoparticle formulation claims 1 , or an aqueous solution.65. The composition of any of - claims 1 , further comprising copper ascorbate and/or ascorbic acid.76. The composition of any of - claims 1 , wherein the effective amount is between 1 mg and 20 mg.86. The composition of any of - claims 1 , wherein the effective amount is between 5 mg and 10 mg.96. The composition of any of - claims 1 , wherein the effective amount is between 7.5 mg and 10 mg.106. The composition of any of - claims 1 , wherein the effective amount is about 10 mg.1514. The method of any of - claims 11 , wherein the subject is a human.1614. The method of any of - claims 11 , wherein the compound is administered in a dose between 1 mg and 20 mg per day.1714. The method of any of - claims 11 , wherein the compound is administered in a dose between 5 mg and 10 mg per day.1814. The method of any of - claims 11 , wherein the compound is administered in a dose between 7.5 mg and 10 mg per day.1914. The method of any of - claims 11 , wherein the compound is administered in a dose of about 10 mg per day.21. The pharmaceutical treatment regime of claim 20 , wherein the pharmacologically active ...

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Номер записи: 57
28-01-2016 дата публикации

ELECTRONIC DEVICE COMPRISING METAL COMPLEXES

Номер: US20160024119A1
Автор: Breuning Esther, STOSSEL Philipp
Принадлежит:

The present invention relates to organic electroluminescent devices comprising metal complexes of the formula (1), and to metal complexes for use in organic electroluminescent devices. 116-. (canceled)21. The compound of claim 17 , wherein M is zirconium claim 17 , hafnium claim 17 , molybdenum claim 17 , tungsten claim 17 , rhenium claim 17 , ruthenium claim 17 , osmium claim 17 , rhodium claim 17 , iridium claim 17 , palladium claim 17 , platinum claim 17 , copper claim 17 , silver claim 17 , gold claim 17 , scandium claim 17 , yttrium claim 17 , lanthanum claim 17 , aluminium claim 17 , gallium claim 17 , or indium.22. The process of claim 18 , wherein M is zirconium claim 18 , hafnium claim 18 , molybdenum claim 18 , tungsten claim 18 , rhenium claim 18 , ruthenium claim 18 , osmium claim 18 , rhodium claim 18 , iridium claim 18 , palladium claim 18 , platinum claim 18 , copper claim 18 , silver claim 18 , gold claim 18 , scandium claim 18 , yttrium claim 18 , lanthanum claim 18 , aluminium claim 18 , gallium claim 18 , or indium.23. The oligomer claim 20 , polymer claim 20 , or dendrimer of claim 20 , wherein M is zirconium claim 20 , hafnium claim 20 , molybdenum claim 20 , tungsten claim 20 , rhenium claim 20 , ruthenium claim 20 , osmium claim 20 , rhodium claim 20 , iridium claim 20 , palladium claim 20 , platinum claim 20 , copper claim 20 , silver claim 20 , gold claim 20 , scandium claim 20 , yttrium claim 20 , lanthanum claim 20 , aluminium claim 20 , gallium claim 20 , or indium.28. The compound of claim 17 , wherein L1 is selected from carbon monoxide claim 17 , isonitriles claim 17 , amines claim 17 , imines claim 17 , diimines claim 17 , phosphines claim 17 , phosphites claim 17 , arsines claim 17 , stibines claim 17 , nitrogen-containing heterocyclic compounds claim 17 , hydride claim 17 , deuteride claim 17 , the halides F claim 17 , Cl claim 17 , Br claim 17 , and I claim 17 , alkylacetylides claim 17 , arylacetylides claim 17 , cyanide claim 17 ...

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Номер записи: 58
28-01-2016 дата публикации

Azolium Metal-Organic Frameworks

Номер: US20160024120A1
Автор: Farha Omar K., Hupp Joseph T., Roberts John M., Scheidt Karl A.
Принадлежит:

Disclosed herein are metal-organic frameworks comprising at least two azolium rings. The azolium groups are used as a strategy for controlling catenation and morphology in metal-organic frameworks. 1. A method for reducing , eliminating or inhibiting catenation in a metal-organic frameworks (MOF) , the method comprisingproviding a biphenyl dicarboxylate derivative having at least two charged groups projecting into pores of the metal-organic framework, the at least two charged groups repulsing each other due to electrostatic van der Waals interactions; andreducing, eliminating or inhibiting cantentation of the metal-organic framework.2. The method according to wherein the metal-organic framework is an azolium-based metal organic framework.5. The method according to wherein the metal ion is Cu.6. The method according to wherein the structure has a formula selected from the group consisting of Cu(4).2 (DMF/EtOH) and ZnO(4) claim 4 , wherein DMF and EtOH are solvent molecules dimethylformamide and ethanol claim 4 , respectively claim 4 , and y is the number of DMF solvent molecules. This application is a continuation of and claims priority to and the benefit of application Ser. No. 13/889,988 filed May 8, 2013 and issued as U.S. Pat. No. 9,090,634 on Jul. 28, 2015, which claimed priority to and the benefit of Ser. No. 61/644,246 filed on May 8, 2012—each of which is incorporated herein by reference in its entirety.This invention was made with government support under FA9550-07-1-0534 awarded by the Air Force Office of Scientific Research. The government has certain rights in the invention.The present invention relates generally to a metal-organic framework comprising at least two azolium rings. The azolium groups are used as a strategy for controlling catenation and morphology in metal-organic frameworks.Metal-organic frameworks (MOFs) have emerged as a promising class of functional materials due to their microporosity, high internal surface area, and the ability to ...

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Номер записи: 59
17-04-2014 дата публикации

HEXAFLUORODIMETHYLCARBINOL TERMINATED ALKANE- AND ALKENETHIOLS

Номер: US20140107362A1
Автор: Snow Arthur W.
Принадлежит: The Government of the United States of America, as represented by the Secretary of the Navy

A hexafluorodimethylcarbinol terminated compound, method of making it, and a composition of matter are disclosed. The compound may have the formula (CF)C(OH)-L-M-R. The substructure L may be selected from an optionally substituted propenylene group (—CHCH═CH—) and trimethylene group (—CHCHCH—). The substructure M may be selected from a substituted or unsubstituted methylene chain, a substituted or unsubstituted oxyalkylene chain, and a silicon-containing chain or combination thereof. In one embodiment, M may be selected from —(CH)—, —(OCHCH)—, and —(Si(CH)O)—Si(CH)—(CH)—, wherein n is at least 1, e.g., n is up to 10, m can be at least 1, e.g., m is up to 10, p can be 0 and in one embodiment is from 1 to 10, and wherein q can be 1 and in one embodiment is from 1 to 12. The substructure R represents one of a halogen, —SH, —SZ, —S—S-M-L-C(CF)(OH), wherein Z represents a thiol protecting group. 1. A composition of matter comprising a metal surface and a group having a general structure represented by (CF)C(OH)-L-M-S— bound to the metal surface:{'sub': 2', '2', '2', '2, 'wherein L is selected from optionally substituted —CH—CH═CH— and —CH—CH—CH—; and'}wherein M is selected from substituted or unsubstituted methylene chain, substituted or unsubstituted oxyalkylene chain, alkyl-substituted or unsubstituted silicon-containing chain, and combinations and multiples thereof.2. The composition of matter of ;{'sub': 2', 'n', '2', '2', 'm', '3', '2', 'p', '3', '2', '2', 'q, 'wherein M is selected from —(CH), —(OCHCH)—, —(Si(CH)O)—Si(CH)—(CH)—, and combinations thereof; and'}wherein n>0; m>0; p>0; and q>1.3. The composition of matter of claim 1 , wherein the metal surface comprises gold.4. The composition of matter of claim 1 , wherein the composition of matter comprises a substrate comprising the metal surface and a film on the metal surface comprising a compound which includes the group (CF)C(OH)-L-M-S—.5. The composition of matter of claim 4 , wherein the compound is present in ...

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Номер записи: 60
10-02-2022 дата публикации

PHOTO TRIGGERED COVALENT ORGANIC FRAMEWORKS AND METHODS OF USING

Номер: US20220041437A1
Автор: Braunecker Wade A., GENNETT Thomas, JOHNSON Justin Carter, LAHTI Gabriella, MOW Rachel Elizabeth, VAN ALLSBURG Kurt Michael, VARDON Derek Richard
Принадлежит:

Described herein are compositions and methods for the storage and release of hydrogen gas using covalent organic frameworks (COFs). Advantageously, the compositions and methods described herein may be used for the facile and rapid release of hydrogen gas at near ambient temperatures. The described COFs allow for photoactivation, where the release of gas is initiated or the rate of release is increased with the COF is exposed to electromagnetic radiation, for example, UV light. 1. A composition comprising:a covalent organic framework (COF) comprising a plurality of Cu(I) moieties, wherein the COF desorbs hydrogen gas when exposed to light.3. The composition of claim 1 , wherein the COF defines a pore.4. The composition of claim 1 , wherein the light is in the UV spectrum selected from the range of 10 nm to 400 nm.5. The composition of claim 1 , further comprising a fluid claim 1 , wherein:the COF and the fluid form a colloidal solution where the COF is stably suspended in the fluid.6. The composition of claim 5 , wherein the COF is present in the form of nanoparticles.7. The composition of claim 5 , wherein the fluid comprises at least one of an ionic liquid or a liquid polymer.8. The composition of claim 7 , wherein the liquid polymer comprises a siloxane.9. The composition of claim 2 , wherein the COF further comprises a capping group.10. The composition of claim 9 , wherein the capping group comprises an aldehyde functionalized tetrakis(3 claim 9 ,5-bis(trifluoromethyl)phenyl)borate)-based ionic liquid compound.11. The composition of claim 1 , wherein the COF also desorbs ethylene when exposed to light.12. The composition of claim 1 , wherein the COF also desorbs carbon monoxide when exposed to light.13. A composition comprising:a covalent organic framework (COF) comprising a plurality of Pd moieties, wherein the COF desorbs hydrogen gas when exposed to light.15. A method comprising:{'sub': '2', 'providing a covalent organic framework (COF) comprising a plurality ...

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Номер записи: 61
10-02-2022 дата публикации

Radiopharmaceuticals, radioimaging agents, and uses thereof

Номер: US20220041608A1
Автор: Nicholas Alan ZIA, Paul Stephen Donnelly
Принадлежит: Clarity Pharmaceuticals Ltd

The present invention relates to compounds that are useful as radiopharmaceuticals and radioimaging agents which bear a radionuclide-chelating agent. These coordinated compounds are useful in radiotherapy and diagnostic imaging. The invention also relates to methods of diagnosis, prognosis and therapy utilising the non-coordinated and radiolabelled compounds of the invention.

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Номер записи: 62
10-02-2022 дата публикации

ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES

Номер: US20220041626A1
Автор: Djurovich Peter I., Razgniaev Anton, Thompson Mark E., Ukwitegetse Narcisse
Принадлежит:

The present disclosure provides amide M carbene emitters of Formula (I); organic light emitting device (OLED) comprising an anode, a cathode, and an organic layer, disposed between the anode and the cathode, comprising a compound of Formula (I); and consumer products comprising an OLED comprising a compound of Formula (I): 2. The compound of claim 1 , wherein M is selected from the group consisting of Cu claim 1 , Ag claim 1 , and Au.3. The compound of claim 1 , wherein ring A is represented by formula (Aii).5. The compound of claim 1 , wherein ring A is represented by formula (Ai).7. The compound of claim 6 , wherein each of Xto Xindependently represents C.17. A formulation comprising the compound of . The present application claims priority to U.S. Provisional Application No. 63/061,263, filed Aug. 5, 2020, which is incorporated by reference herein in its entirety.The present disclosure relates to compounds for use as emitters, and devices, such as organic light emitting diodes, including the same.The claimed invention was made by, on behalf of, and/or in connection with one or more of the following parties to a joint university corporation research agreement: Regents of the University of Michigan, Princeton University, University of Southern California, and the Universal Display Corporation. The agreement was in effect on and before the date the claimed invention was made, and the claimed invention was made as a result of activities undertaken within the scope of the agreement.Opto-electronic devices that make use of organic materials are becoming increasingly desirable for a number of reasons. Many of the materials used to make such devices are relatively inexpensive, so organic opto-electronic devices have the potential for cost advantages over inorganic devices. In addition, the inherent properties of organic materials, such as their flexibility, may make them well suited for particular applications such as fabrication on a flexible substrate. Examples of ...

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Номер записи: 63
10-02-2022 дата публикации

ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES

Номер: US20220041636A1
Автор: Boudreault Pierre-Luc T.
Принадлежит: UNIVERSAL DISPLAY CORPORATION

A compound comprising a first ligand Lof Formula I, 2. The compound of claim 1 , wherein each R claim 1 , R claim 1 , R claim 1 , R claim 1 , and R′ is independently a hydrogen or a substituent selected from the group consisting of deuterium claim 1 , fluorine claim 1 , alkyl claim 1 , cycloalkyl claim 1 , heteroalkyl claim 1 , alkoxy claim 1 , aryloxy claim 1 , amino claim 1 , silyl claim 1 , alkenyl claim 1 , cycloalkenyl claim 1 , heteroalkenyl claim 1 , aryl claim 1 , heteroaryl claim 1 , nitrile claim 1 , isonitrile claim 1 , sulfanyl claim 1 , and combinations thereof.3. The compound of claim 1 , wherein the fused ring structure is naphthalene claim 1 , phenalene claim 1 , anthracene claim 1 , phenanthrene claim 1 , fluorene claim 1 , pyrene claim 1 , chrysene claim 1 , perylene claim 1 , azulene claim 1 , dibenzothiophene claim 1 , dibenzofuran claim 1 , dibenzoselenophene claim 1 , benzofuran claim 1 , benzothiophene claim 1 , benzoselenophene claim 1 , carbazole claim 1 , indolocarbazole claim 1 , pyridylindole claim 1 , indole claim 1 , benzimidazole claim 1 , indazole claim 1 , indoxazine claim 1 , benzoxazole claim 1 , benzisoxazole claim 1 , benzothiazole claim 1 , quinoline claim 1 , isoquinoline claim 1 , cinnoline claim 1 , quinazoline claim 1 , quinoxaline claim 1 , phthalazine claim 1 , xanthene claim 1 , acridine claim 1 , phenazine claim 1 , phenothiazine claim 1 , phenoxazine claim 1 , benzothienopyridine claim 1 , benzoselenophenopyridine claim 1 , and selenophenodipyridine.6. The compound of claim 1 , wherein M is selected from the group consisting of Os claim 1 , Ir claim 1 , Pd claim 1 , Pt claim 1 , Cu claim 1 , and Au.7. The compound of claim 1 , wherein Yand Yare both S claim 1 , or Yand Yare both O.8. The compound of claim 1 , wherein Zto Zare C.9. The compound of claim 1 , wherein at least one of Zto Zare N.12. The compound of claim 1 , wherein the compound has a formula of M(L)(L)(L)wherein Land Lare each a bidentate ligand; and ...

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Номер записи: 64
24-01-2019 дата публикации

GOLD(III) COMPLEXES AS ANTICANCER AGENTS AND A METHOD OF TREATING CANCER

Номер: US20190023721A1
Автор: ALTAF Muhammad, ISAB Anvar Husain Abdul Kadir
Принадлежит: KING FAHD UNIVERSITY OF PETROLEUM AND MINERALS

Gold(III) complexes containing mixed ligands. A method of treating cancer with these complexes is disclosed. The complexes are cytotoxic to prostate, breast, ovarian, and Hodgkin lymphoma cancer cell lines. These complexes were either more potent than cisplatin or had similar potency to cisplatin. 2. The gold(III) complex of claim 1 , wherein the gold(III) complex is represented by formula (III) claim 1 , a salt thereof claim 1 , a solvate thereof claim 1 , a derivative thereof claim 1 , or a prodrug thereof claim 1 , and R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , and Rare independently a hydrogen or an optionally substituted alkyl.3. The gold(III) complex of claim 2 , wherein Rand Rare independently an optionally substituted alkyl or an optionally substituted arylalkyl.4. The gold(II) complex of claim 3 , further comprising a counterion which is at least one pharmaceutically acceptable anion selected from the group consisting of fluoride claim 3 , chloride claim 3 , bromide claim 3 , iodide claim 3 , nitrate claim 3 , sulfate claim 3 , phosphate claim 3 , methanesulfonate claim 3 , ethanesulfonate claim 3 , p-toluenesulfonate claim 3 , salicylate claim 3 , malate claim 3 , maleate claim 3 , succinate claim 3 , tartrate claim 3 , citrate claim 3 , acetate claim 3 , perchlorate claim 3 , trifluoromethanesulfonate claim 3 , acetylacetonate claim 3 , hexafluorophosphate claim 3 , and hexafluoroacetylacetonate.5. The gold(III) complex of claim 4 , wherein R claim 4 , R claim 4 , R claim 4 , R claim 4 , R claim 4 , R claim 4 , R claim 4 , and Rare independently a hydrogen or a methyl claim 4 , and Rand Rare independently a methyl claim 4 , an ethyl claim 4 , or benzyl.6. A pharmaceutical composition claim 4 , comprising:{'claim-ref': {'@idref': 'CLM-00001', 'claim 1'}, 'the gold(II) complex of ; and'}at least one pharmaceutically acceptable carrier and/or excipient.7. The pharmaceutical composition of claim 6 , wherein the at ...

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Номер записи: 65
28-01-2021 дата публикации

Near-infrared absorbing composition, near-infrared absorbing film, and image sensor for solid-state imaging element

Номер: US20210026053A1
Автор: Issei NAKAHARA, Keigo TAMAKI, Kenji Hayashi, Kiyoshi Fukusaka, Koji Daifuku, Natsumi ITAMOTO, Takahiko Nojima, Yosuke Mizutani, Yutaro HORIE
Принадлежит: KONICA MINOLTA INC

Disclosed is a near-infrared absorbing composition, including: a near-infrared absorbing agent; and a solvent, wherein the near-infrared absorbing agent includes at least one of the following Component (A) and Component (B): Component (A): a component composed of a compound having a structure of the following general formula (I) and a metal ion; Component (B): a component composed of a metal complex that is obtainable by a reaction of the compound having the structure of the following general formula (I) and a metal compound.

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Номер записи: 66
01-02-2018 дата публикации

SYSTEMS AND METHODS INCORPORATING IONIC LIQUIDS FOR ELECTROCHEMICALLY MEDIATED CAPTURING OF LEWIS ACID GASES

Номер: US20180028962A1
Автор: Brown Paul, Hatton Trevor Alan, Voskian Sahag
Принадлежит: Massachusetts Institute of Technology

The present invention generally relates to methods and systems for capturing a Lewis acid gas (e.g., CO). In some embodiments, the methods and systems utilize an ionic liquid incorporated into one or more electrochemical cells. 1. A method for capturing a Lewis acid gas , comprising:providing a system comprising a first zone and a second zone in fluid connection with the first zone, wherein:the first zone comprises a functional ionic liquid comprising a cation and an anion; andthe second zone comprises a complexation agent capable of associating and/or disassociating the cation to and/or from the functional ionic liquid upon exposure to an electrical potential;exposing the ionic liquid to the Lewis acid gas in the first zone, wherein the cation associates with the Lewis acid gas to form a cation-Lewis-acid-gas complex; andexposing the cation-Lewis-acid-gas complex to the complexation agent in the second zone, wherein the complexation agent associates with the cation to form a cation-complexation agent complex and the Lewis acid gas is released to form free Lewis acid gas.3. The method according to claim 2 , wherein n is 2.4. The method according to claim 3 , wherein R is H.5. The method according to claim 2 , wherein m is 6 and R″ is H.6. The method according to claim 2 , wherein Ris 2-ethylhexyl.7. The method according to claim 1 , wherein the anion of the functional ionic liquid is selected from the group consisting of boron tetrafluoride claim 1 , phosphorus tetrafluoride claim 1 , phosphorus hexafluoride claim 1 , alkylsulfonate claim 1 , fluoroalkylsulfonate claim 1 , arylsulfonate claim 1 , bis(alkylsulfonyl)amide claim 1 , bis(fluoroalkylsulfonyl)amide claim 1 , bis(arylsulfonyl)amide claim 1 , (fluoroalkylsulfonyl)(fluoroalkylcarbonyl)amide claim 1 , halide claim 1 , nitrate claim 1 , nitrite claim 1 , sulfate claim 1 , hydrogensulfate claim 1 , alkyl sulfate claim 1 , aryl sulfate claim 1 , carbonate claim 1 , bicarbonate claim 1 , carboxylate claim 1 , ...

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Номер записи: 67
04-02-2016 дата публикации

PHOTOACTIVE ENERGETIC MATERIALS

Номер: US20160031767A1
Автор: Chavez David E., Hanson Susan Kloek, Myers Thomas Winfield, Scharff Robert Jason, Veauthier Jacqueline Marie
Принадлежит:

Energetic materials that are photoactive or believed to be photoactive may include a conventional explosive (e.g. PETN, nitroglycerine) derivatized with an energetic UV-absorbing and/or VIS-absorbing chromophore such as 1,2,4,5-tetrazine or 1,3,5-triazine. Absorption of laser light having a suitably chosen wavelength may result in photodissociation, decomposition, and explosive release of energy. These materials may be used as ligands to form complexes. Coordination compounds include such complexes with counterions. Some having the formula M(L) were synthesized, wherein M is a transition metal and L is a ligand and n is 2 or 3. These may be photoactive upon exposure to a laser light beam having an appropriate wavelength of UV light, near-IR and/or visible light. Photoactive materials also include coordination compounds bearing non-energetic ligands; in this case, the counterion may be an oxidant such as perchlorate. 3. The composition of claim 1 , wherein X═Y═—OCHC(CHONO).4. The composition of claim 1 , wherein X═Y═—OCHC((F)(NO)).5. The composition of claim 1 , wherein X═Y═—OCH(ONO).9. A coordination compound comprising:a cationic complex comprising a transition metal center;at least one ligand comprising a 1,2,4,5-tetrazine ring or a 1,3,5-triazine ring coordinated to the transition metal center;at least one explosive pendant group covalently bonded to the 1,2,4,5-tetrazine ring or 1,3,5-triazine ring; anda counterion.10. The coordination compound of claim 9 , wherein the transition metal center comprises Fe claim 9 , Cu claim 9 , Ni claim 9 , or Co.14. The coordination compound of claim 9 , wherein the counterion is selected from tetrafluoroborate (BF) claim 9 , nitrate (NO) claim 9 , perchlorate (ClO) claim 9 , sulfate (SO) claim 9 , phosphate (PO) claim 9 , and carbonate (CO). This application claims the benefit of U.S. Provisional Patent Application No. 61/993,707 entitled “Photoactive Energetic Materials,” filed May 15, 2014, which is hereby incorporated by ...

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Номер записи: 68
29-01-2015 дата публикации

TRANSITION METAL COMPLEXES OF A BIS[THIOHYDRAZIDE AMIDE] COMPOUND

Номер: US20150031758A1
Автор: Nagai Masazumi, Shen Jianhua
Принадлежит:

The present invention is directed to a compound comprising a bis[thiohydrazide amide] or a deprotonated form thereof, complexed to a transition metal cation, wherein the bis[thiohydrazide amide] is represented by Structural Formula (I): or a prodrug, isomer, ester, salt, hydrate, solvate, polymorph or a deprotonated form thereof. The present invention also provides a pharmaceutical composition comprising a compound of the invention and method of use thereof. 120-. (canceled)2224-. (canceled)25. The method of claim 21 , further comprising administering to the subject an effective amount of paclitaxel or a paclitaxel analog.26. The method of claim 21 , wherein the compound is greater than 90% pure by weight.27. The method of claim 21 , wherein the transition metal cation has a charge of +2.28. The method of claim 27 , wherein the transition metal cation is Ni claim 27 , Cu claim 27 , Co claim 27 , Fe claim 27 , Zn claim 27 , Pt or Pd.29. The method of claim 28 , wherein the transition metal cation is Cu.30. The method of claim 21 , wherein the molar ratio of bis[thiohydrazide amide] or deprotonated form thereof to transition metal cation is equal to or greater than 0.5 and equal to or less than 2.0.31. The method of claim 30 , wherein the molar ratio of bis[thiohydrazide amide] or deprotonated form thereof to transition metal cation is 1:1.33. The method of claim 32 , wherein the compound is greater than 90% pure by weight.34. The method of claim 33 , wherein X is Ni claim 33 , Cu claim 33 , Co claim 33 , Fe claim 33 , Zn claim 33 , Pt or Pd.35. The method of claim 34 , wherein X is Cu.36. The method of claim 32 , further comprising administering to the subject an effective amount of paclitaxel or a paclitaxel analog. This application claims the benefit of U.S. Provisional Application No. 61196,943, filed Oct. 22, 2008 and is incorporated herein by reference in its entirety.It has been reported in U.S. Pat. Nos. 6,800,660; 6,762,204; 7,037,940; 7,001,923; and 6,924, ...

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Номер записи: 69
17-02-2022 дата публикации

Synthesis and Antimicrobial Uses of Dinuclear Silver(I) Pyrazolates

Номер: US20220047628A1
Автор: CHAKRABORTY INDRANIL, KANDEL SHAMBHU, RAPTIS RAPHAEL G.
Принадлежит: THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES

Novel dinuclear silver(I) pyrazolido complexes and methods of synthesizing them are provided. Advantageously, the novel silver(I) pyrazolido complexes have excellent antimicrobial activity and methods of using said complexes to treat bacterial, fungal, and viral infections are also provided. 2. The dinuclear silver(I) pyrazolido complex claim 1 , according to claim 1 ,{'sup': 1', '2', '3', '4', '5, 'wherein Rand Rare PTA; and R, R, and Rare each independently selected from the group consisting of hydrogen, halogen, hydroxyl, nitro, alkyl, alkenyl, aryl, formyl, acetyl, hydroxyalkyl, halogen substituted alkyl, halogen substituted aryl, halogen substituted sulfuryl, imine-linked PTA, amine-linked PTA, imine-linked adamantane, amine-linked adamantane, imine-linked triphenylphosphine, and amine-linked triphenylphosphine.'}3. The dinuclear silver(I) pyrazolido complex claim 1 , according to claim 1 ,{'sup': 1', '2', '3', '4', '5, 'wherein Rand Rare phosphaadamantane; and R, R, and Rare each independently selected from the group consisting of hydrogen, halogen, hydroxyl, nitro, alkyl, alkenyl, aryl, formyl, acetyl, halogen substituted alkyl, hydroxyalkyl, halogen substituted aryl, halogen substituted sulfuryl, imine-linked PTA, amine-linked PTA, imine-linked adamantane, amine-linked adamantine, imine-linked triphenylphosphine, and amine-linked triphenylphosphine.'}4. The dinuclear silver(I) pyrazolido complex claim 1 , according to claim 1 , wherein Rand Rare (4-sulfophenyl)diphenylphosphine; and R claim 1 , R claim 1 , and Rare each independently selected from the group consisting of hydrogen claim 1 , halogen claim 1 , hydroxyl claim 1 , nitro claim 1 , alkyl claim 1 , alkenyl claim 1 , aryl claim 1 , formyl claim 1 , acetyl claim 1 , hydroxyalkyl claim 1 , halogen substituted alkyl claim 1 , halogen substituted aryl claim 1 , halogen substituted sulfuryl claim 1 , imine-linked PTA claim 1 , amine-linked PTA claim 1 , imine-linked adamantane claim 1 , amine-linked ...

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Номер записи: 70
30-01-2020 дата публикации

WATER CAPTURE METHODS, DEVICES, AND COMPOUNDS

Номер: US20200030737A1
Автор: "OHearn Daniel J.", BEZRUKOV Andrey Alexandrovich, PÉREZ Victoria Gascón, WANG Shiqiang, ZAWOROTKO Michael John
Принадлежит:

A method of capturing water from a gaseous composition comprising water vapour (e.g., air), the method comprising: 143.-. (canceled)44. A method of capturing water from a gaseous composition , the method comprising:providing a metal-organic material configured to capture water from the gaseous composition;contacting the metal-organic material with the gaseous composition;wherein the gaseous composition comprises one or more of water or water vapor; andwherein the metal-organic material adsorbs water from the gaseous composition.45. The method of claim 44 , further comprising storing the metal-organic material after the metal-organic material adsorbs water from the gaseous composition.46. The method of claim 45 , further comprising applying a stimulus to the metal-organic material at a time after storage to effect desorption of water retained therein.47. The method of claim 46 , further comprising collecting desorbed water.48. The method of claim 44 , wherein the metal-organic material comprises metal species and one or more ligands.49. The method of claim 48 , wherein the metal species is selected from copper claim 48 , cobalt claim 48 , nickel claim 48 , iron claim 48 , zinc claim 48 , cadmium claim 48 , zirconium claim 48 , magnesium claim 48 , calcium and aluminium.50. The method of claim 48 , wherein the one or more ligands are selected from bidentate nitrogen ligands claim 48 , nitrogen-carboxylate ligands and polycarboxylate ligands.51. The method of claim 50 , wherein the one or more ligands are selected from 4 claim 50 ,4′ -bipyridine (L1) claim 50 , 1 claim 50 ,4-bis(4-pyridyl)benzene (L2) claim 50 , 4 claim 50 ,4′ -(2 claim 50 ,5 -dimethyl-1 claim 50 ,4-phenylene)dipyridine (L3) claim 50 , 1 claim 50 ,4-bis(4-pyridyl)biphenyl (L4) claim 50 , 1 claim 50 ,2-di(pyridine-4-yl)-ethene (L5) claim 50 , benzotriazole-5-carboxylic acid (L128) claim 50 , 2 claim 50 ,4-pyridinedicarboxylic acid (L80) claim 50 , glutaric acid (L141) claim 50 , and benzene-1 claim 50 , ...

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Номер записи: 71
30-01-2020 дата публикации

NEAR-INFRARED ABSORBING COMPOSITION, OPTICAL STRUCTURE, AND CAMERA MODULE AND ELECTRONIC DEVICE COMPRISING THE SAME

Номер: US20200031849A1
Автор: JUNG Myungsup, KIM Changki, KIM Mi Jeong, WON Jong Hoon
Принадлежит: SAMSUNG ELECTRONICS CO., LTD.

Disclosed are a near-infrared absorbing composition, an optical structure, and a camera module and an electronic device including the same. The near-infrared absorbing composition includes a copper complex represented by Chemical Formula 1. 3. The near-infrared absorbing composition of claim 1 , wherein at least one of Rand Ris a photo-polymerizable functional group.4. The near-infrared absorbing composition of claim 3 , wherein{'sup': '1', 'Ris one of a substituted or unsubstituted C1 to C20 alkyl group, a substituted or unsubstituted C1 to C20 cycloalkyl group, or a substituted or unsubstituted C1 to C20 aryl group, and'}{'sup': '2', 'Ris a photo-polymerizable functional group.'}6. The near-infrared absorbing composition of claim 5 , wherein m is 1 and one of k and l is 0.7. The near-infrared absorbing composition of claim 5 , whereinm is 1, andk and l are independently be an integer in a range of 1 to 8.9. The near-infrared absorbing composition of claim 1 , further comprising:a polymerizable monomer that is thermally cross-linkable or photo-cross-linkable; anda solvent.10. The near-infrared absorbing composition of claim 9 , wherein the polymerizable monomer includes an acryl-based monomer claim 9 , an epoxy-based monomer claim 9 , a vinyl-based monomer claim 9 , or a combination thereof.11. The near-infrared absorbing composition of claim 9 , wherein the solvent includes ethanol claim 9 , methanol claim 9 , benzene claim 9 , toluene claim 9 , xylene claim 9 , NMP (N-methylpyrrolidone) claim 9 , acrylonitrile claim 9 , acetonitrile claim 9 , THF (tetrahydrofuran) claim 9 , ethyl acetate claim 9 , MEK (methylethylketone) claim 9 , butylcarbitol claim 9 , butylcarbitolacetate claim 9 , butylcellosolve claim 9 , butylcellosolveacetate claim 9 , ethylcarbitol claim 9 , ethylcarbitolacetate claim 9 , IPA (isopropylalcohol) claim 9 , acetone claim 9 , DMF (dimethyl formamide) claim 9 , DMSO (dimethylsulfoxide) claim 9 , piperidine claim 9 , phenol claim 9 , MIBK ( ...

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Номер записи: 72
04-02-2021 дата публикации

RADIOLABELING AGENTS, METHODS OF MAKING, AND METHODS OF USE THEREOF

Номер: US20210032184A1
Автор: HASKALI Mohammad Baqir, PIKE Victor William, TELU Sanjay, YANG Bo Yeun
Принадлежит:

Described herein are labeling agents, specifically [C]fluoroform, [C]difluoromethane, [C]fluoromethyl iodide, [C]fluoromethyl bromide, [C]fluoromethyl chloride, [C]fluoromethyl trifluoromethansulfonate, [C]difluoromethyl iodide, [C]difluoromethyl bromide, [C]difluoromethyl chloride, [C]difluoromethyl trifluoromethansulfonate, [C]trifluoromethyl iodide, [C]trifluoromethyl bromide, [C]trifluoromethyl chloride, [C]trifluoromethyl trifluoromethansulfonate, []fluoroform, [F]difluoromethane, [F]difluoromethyl bromide or [F]trifluoromethyl bromide. Also included are methods of labeling precursors to provide labeled fluoroalkanes and imaging methods. 1. A gas phase solvent-free method for producing an C- or F-labeled fluoroalkane , the method comprising{'sup': 11', '18', '18', '11', '11, 'sub': 11', '11', '3, 'contacting [C]methane, [F]fluoromethane, [F]fluoromethyl bromide, [C]methyl iodide, [C]methyl bromide, [C]methyl chloride, or [C]methyl trffluoromethansuifonate, with CoFat a temperature of 50 to 450° C., and'}{'sup': 11', '18, 'isolating the C- or F-labeled fluoroalkane that is produced.'}2. The method of claim 1 , wherein{'sup': 11', '11, 'the precursor is [C]methane and the labeled fluoroalkane is [C]fluoroform,'}{'sup': 18', '18, 'the precursor is [F]fluoromethane and the labeled fluoroalkane is [F]fluoroform,'}{'sup': 18', '18, 'the precursor is [F]fluoromethane and the labeled fluoroalkane is [F]difluoromethane,'}{'sup': 18', '18, 'the precursor is [F]fluoromethyl bromide and the labeled fluoroalkane is [F]difluoromethyl bromide,'}{'sup': 18', '18, 'the precursor is [F]fluoromethyl bromide and the labeled fluoroalkane is [F]trifluoromethyl bromide,'}{'sup': 11', '11, 'the precursor is [C]methyl iodide and the labeled fluoroalkane is [C]fluoromethyl iodide,'}{'sup': 11', '11, 'the precursor is [C]methyl bromide and the labeled fluoroalkane is [C]fluoromethyl bromide,'}{'sup': 11', '11, 'the precursor is [C]methyl chloride and the labeled fluoroalkane is [C] ...

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Номер записи: 73
04-02-2021 дата публикации

Method of producing a 2-((meth)allyloxymethyl)acrylic acid derivative, and 2-((meth)allyloxymethyl)acrylic acid alkali metal salt powder

Номер: US20210032187A1
Автор: Jun Moteki, Kazuhiko Nakamura, Minoru Urata
Принадлежит: NIPPON SHOKUBAI CO LTD

Provided is a method of producing various 2-((meth)allyloxymethyl)acrylic acid derivatives in high yields with no need to load a raw material in a large excess for improving a reaction conversion ratio, and without use of a catalyst having high toxicity or a strong acid catalyst. Also provided are powder compounds that may be utilized as raw materials for synthesizing various chemical products. A method of producing a 2-((meth)allyloxymethyl)acrylic acid derivative includes causing the powder of a salt of a 2-((meth)allyloxymethyl)acrylic acid anion and an alkali metal cation (component A), and a halide (component B) to react with each other to produce a 2-((meth)allyloxymethyl)acrylic acid derivative. The 2-((meth)allyloxymethyl)acrylic acid alkali metal salt powder is the powder of a salt of a 2-((meth)allyloxymethyl)acrylic acid anion and an alkali metal cation, and has a bulk density of 0.50 g/mL or more, or a water content of 0.05 wt % or less.

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Номер записи: 74
01-02-2018 дата публикации

ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES

Номер: US20180033977A1
Автор: Djurovich Peter I., Krylova Valentina, Thompson Mark E.
Принадлежит: UNIVERSITY OF SOUTHERN CALIFORNIA

A compound having a structure according to formula (I) 2. The compound of claim 1 , wherein Y includes a carbene carbon that is coordinated to the Cu atom.3. The compound of claim 1 , wherein the ring formed from Xand Xis part of a polycyclic ring system.6. The compound of claim 1 , wherein Y is selected from the group consisting of aryl claim 1 , heteroalkyl claim 1 , and heteroaryl.8. The compound of claim 7 , wherein Yin formula (I) is selected from the group consisting of aryl claim 7 , heteroalkyl claim 7 , and heteroaryl.9. A consumer product including a display claim 1 , the display including an organic light emitting device comprising an anode claim 1 , a cathode claim 1 , and an organic layer disposed between the anode and the cathode claim 1 , the organic layer comprising a compound of and a host.10. The product of selected from the group consisting of flat panel displays claim 9 , computer monitors claim 9 , medical monitors claim 9 , televisions claim 9 , billboards claim 9 , lights for interior or exterior illumination and/or signaling claim 9 , heads up displays claim 9 , fully transparent displays claim 9 , flexible displays claim 9 , laser printers claim 9 , telephones claim 9 , cell phones claim 9 , personal digital assistants (PDAs) claim 9 , laptop computers claim 9 , digital cameras claim 9 , camcorders claim 9 , viewfinders claim 9 , micro-displays claim 9 , 3-D displays claim 9 , vehicles claim 9 , a wall claim 9 , theater or stadium screen claim 9 , and a sign.11. An organic light emitting device that includes an anode claim 1 , a cathode claim 1 , and an organic layer disposed between the anode and the cathode claim 1 , wherein the organic layer is an emissive layer that comprises a compound of and a host claim 1 , the compound being an emissive dopant.12. An organic light emitting device that includes an anode claim 1 , a cathode claim 1 , and an organic layer disposed between the anode and the cathode claim 1 , wherein the organic layer ...

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Номер записи: 75
05-02-2015 дата публикации

METAL COMPLEXES AS IMAGING AGENTS

Номер: US20150037253A1
Автор: Barnham Kevin, Donnelly Paul, Hickey James, Lim Sin Chun
Принадлежит:

The present invention relates to copper, gallium and technetium coordinated thiosemicarbazone-pyridylhydrazine (substituted at the pyridine ring with a substituted benzothiazole or stilbene moiety) complexes and methods thereof. Such compounds possess utility in PET imaging and diagnosis of amyloid diseases. 3. A metal complex according to wherein the complex is a metal complex of formula (Ia) claim 2 , or a salt thereof.4. A metal complex according to wherein the complex is a metal complex of formula (Ib) claim 2 , or a salt thereof.5. A metal complex according to any one of to wherein Ris hydrogen.6. A metal complex according to any one of to wherein Ris hydrogen and Ris an optionally substituted C-Calkyl.7. A metal complex according to any one of to wherein Ris hydrogen and Ris C-Calkyl.8. A metal complex according to any one of to wherein Ris hydrogen and Ris a substituted C-Calkyl.9. A metal complex according to any one of to wherein Ris hydrogen and Ris a terminally substituted C-Calkyl.10. A metal complex according to any one of to wherein Ris hydrogen and Ris a C-Calkyl terminally substituted with a group selected from halogen claim 2 , amino claim 2 , C-Cdialkyl amino claim 2 , C-Cmonoalkyl amino claim 2 , aryl claim 2 , carboxyl claim 2 , trihalomethyl claim 2 , acyl claim 2 , and N-containing heteroaryl or N-containing heterocyclyl.11. A metal complex according to any one of to wherein Ris a C-Calkyl terminally substituted with C-Cdialkyl amino and C-Cmonoalkyl amino claim 2 , or a bioisostere thereof.12. A metal complex according to any one of to wherein Ris hydrogen and Ris C-Calkyl or di C-Calkyl amino ethyl.13. A metal complex according to any one of to wherein Ris hydrogen and Ris methyl or dimethylaminoethyl.14. A metal complex according to any one of to wherein Rand Rare independently C-Calkyl.15. A metal complex according to any one of to wherein Rand Rare both methyl.16. A metal complex according to any one of to wherein Ris hydrogen claim 2 , ...

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Номер записи: 76
04-02-2016 дата публикации

NEAR-INFRARED-RAY-ABSORBING COMPOSITION, NEAR-INFRARED-RAY CUT FILTER USING SAME, MANUFACTURING METHOD THEREFOR, CAMERA MODULE, AND MANUFACTURING METHOD THEREFOR

Номер: US20160037034A1
Автор: HITOMI Seiichi, Inasaki Takeshi, KAWASHIMA Takashi, SASAKI Kouitsu
Принадлежит: FUJIFILM Corporation

Provided are a near-infrared-ray-absorbing composition having strong near-infrared shielding properties when a cured film is produced, a near-infrared-ray cut filter, a manufacturing method therefor, a camera module, and a manufacturing method therefor. The near-infrared-ray-absorbing composition includes a copper complex obtained by reacting a compound (A) having at least two coordination sites with a copper component. 1. A near-infrared-ray-absorbing composition comprising:a copper complex obtained by reacting a compound (A) having at least two coordination sites with a copper component.2. A near-infrared-ray-absorbing composition comprising:a copper complex obtained by reacting a compound (A1) having two monoanionic coordination sites or a compound having a salt of the compound (A1) with a copper component.3. The near-infrared-ray-absorbing composition according to claim 1 ,wherein the compound (A) is a compound (A2) respectively having at least one coordination site to be coordinated with an anion and at least one coordinating atom to be coordinated with an unshared electron pair.4. The near-infrared-ray-absorbing composition according to claim 1 ,wherein the compound (A) is a compound (A3) having two or more coordinating atoms to be coordinated with an unshared electron pair.5. The near-infrared-ray-absorbing composition according to claim 2 , {'br': None, 'sup': 1', '1', '2, 'X-L-X\u2003\u2003Formula (10)'}, 'wherein the compound (A1) is represented by Formula (10) described below{'sup': 1', '2', '1', 'N1', 'N1, 'sub': '2', 'wherein, in Formula (10), each of Xand Xindependently represents the monoanionic coordination site, and Lrepresents an alkylene group, an alkenylene group, an arylene group, a heterocyclic group, —O—, —S—, —NR—, —CO—, —CS—, —SO—, or a divalent linking group formed of a combination thereof; here, Rrepresents a hydrogen atom, an alkyl group, an aryl group, or an aralkyl group.'}11. The near-infrared-ray-absorbing composition according to ...

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Номер записи: 77
05-02-2015 дата публикации

LIGAND PASSIVATED GOLD NANOPARTICLES

Номер: US20150037585A1
Автор: Ackerson Christopher J., Compel William S., Wong On Lo A.
Принадлежит: COLORADO STATE UNIVERSITY RESEARCH FOUNDATION

The invention provides novel gold nanoclusters of the formula Au(SR)(weak ligand), wherein each R is independently an organic group, and the weak ligand is a weakly associating gold ligand of Formula I as described herein. The nanocluster can have an approximate molecular weight of 6 kDa. Corresponding dimers of the nanocluster can have an approximate molecular weight of 10 kDa (by SEC). The invention also provides methods of making and using the gold nanoclusters. 2. The gold nanocluster of further comprising a second gold nanocluster claim 1 , thereby forming a discrete gold nanocluster of the formula (Au(SR))(weak ligand) claim 1 , wherein the nanocluster has an approximate molecular weight of 10 kDa and is orange in color upon isolation.3. The gold nanocluster of wherein the nanocluster is water-soluble.4. The gold nanocluster of wherein the nanocluster is organo-soluble.5. The gold nanocluster of wherein x is 20 claim 1 , 24 claim 1 , 25 claim 1 , or 28.6. The gold nanocluster of wherein y is 15 claim 1 , 17 claim 1 , or 19.7. The gold nanocluster of wherein each Rand Ris OMe.8. The gold nanocluster of wherein n is 1 claim 1 , 2 claim 1 , or 3.9. The gold nanocluster of wherein the weak ligand of Formula I is diethylene glycol dimethyl ether claim 1 , triethylene glycol dimethyl ether claim 1 , or tetraethylene glycol dimethyl ether.10. The gold nanocluster of wherein -SR is the thiolate of glutathione claim 1 , cysteine claim 1 , captopril claim 1 , thiomalic acid claim 1 , N-(2-mercaptopropionyl)glycine claim 1 , p-mercaptobenzioc acid claim 1 , m-mercaptobenzoic acid claim 1 , furan-2-ylmethanethiol claim 1 , penicillamine claim 1 , a (C-C)mercaptoalkanoic acid claim 1 , 2-phenylethanethiol (PET) claim 1 , 1-phenylethanethiol claim 1 , benzyl mercaptan claim 1 , thiophenol claim 1 , a (C-C)alkylthiol claim 1 , a (C-C)mercaptocycloalkane claim 1 , a (C-C)mercaptoalkanoic acid claim 1 , dimercaptosuccinic acid claim 1 , 2-mercaptoethanol claim 1 , 3- ...

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Номер записи: 78
05-02-2015 дата публикации

N-acetyl l-cysteine chelates and methods for making and using the same

Номер: US20150038577A1
Автор: Patricia Gahan, Rhett Sean Daniels, Xueju Xie
Принадлежит: Individual

A nutritional supplement for a human, the supplement having a chelate comprised of an N-acetyl-L-cysteine ligand bonded to a metal to form a chelate ring. A method for preparing a chelate comprised of N-acetyl-L-cysteine ligand and a metal having the steps of: dissolving an amount of N-acetyl-L-cysteine in an aqueous solution, adding a metal to the aqueous solution, stifling and heating the aqueous solution, and removing the solvent under reduced pressure. A method of treating a human for one or more of oxidative stress, cardiovascular disease, cerebrovascular disease, neurodegenerative diseases, Alzheimer's disease, ADHD, bipolar, schizophrenia, autism, dementia, and HIV in a human comprising administering an effective amount of a composition having N-acetyl-L-cysteine in a chelate formation with a metal. A compound having a chelate formulation with a metal being chelated by an N-acetyl-L-cysteine ligand.

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Номер записи: 79
05-02-2015 дата публикации

METHODS FOR THE PREPARATION OF HIV ATTACHMENT INHIBITOR PIPERAZINE PRODRUG COMPOUND

Номер: US20150038712A1
Автор: Bultman Michael S., CHEN KE, Eastgate Martin D., Fanfair Dayne Dustan, Fox Richard J., La Cruz Thomas E., Mudryk Boguslaw M., Risatti Christina Ann, Simpson James H., Soumeillant Maxime C., Tripp Jonathan Clive, Xiao Yi
Принадлежит:

A method for making the compound This application is a divisional application of U.S. Ser. No. 13/760,526 filed Feb. 6, 2013, now allowed, which claims the benefit of U.S. Provisional Application Ser. No. 61/596,362 filed Feb. 8, 2012, which is herein incorporated by reference in its entirety.The invention relates to methods of making HIV attachment inhibitor compounds useful as antivirals, and in particular, to methods of making the piperazine prodrug compound identified as 1-benzoyl-4-[2-[4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-yl)-1-[(phosphonooxy)methyl]-1H-pyrrolo[2,3-c]pyridin-3-yl]-1,2-dioxoethyl]-piperazine. The invention also relates to the compounds, including intermediates, obtained by the processes herein set forth.HIV-1 (human immunodeficiency virus-1) infection remains a major medical problem, with tens of millions of people still infected worldwide at the end of 2011. The number of cases of HIV and AIDS (acquired immunodeficiency syndrome) has risen rapidly. In 2005, for example, approximately 5.0 million new infections were reported, and 3.1 million people died from AIDS. Currently available drugs for the treatment of HIV include nucleoside reverse transcriptase (RT) inhibitors or approved single pill combinations: zidovudine (or AZT or RETROVIR®), didanosine (or VIDEX®), stavudine (or ZERIT®) lamivudine (or 3TC or EPIVIR®), zalcitabine (or DDC or HIVID®), abacavir succinate (or ZIAGEN®), Tenofovir disoproxil fumarate salt (or VIREAD®), emtricitabine (or FTC or EMTRIVA®), COMBIVIR® (contains -3TC plus AZT), TRIZIVIR® (contains abacavir, lamivudine, and zidovudine), EPZICOM® (contains abacavir and lamivudine), TRUVADA® (contains VIREAD® and EMTRIVA®); non-nucleoside reverse transcriptase inhibitors: nevirapine (or VIRAMUNE®), delavirdine (or RESCRIPTOR®) and efavirenz (or SUSTIVA®), ATRIPLA® (TRUVADA®+SUSTIVA®), and etravirine, and peptidomimetic protease inhibitors or approved formulations: saquinavir, indinavir, ritonavir, nelfinavir, amprenavir, ...

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Номер записи: 80
08-02-2018 дата публикации

PHTHALOCYANINE-BASED COMPLEX COMPOUND

Номер: US20180037740A1
Автор: ISHII Yasuhisa, IWATA Ryosuke, MIZUNO Mikihisa
Принадлежит: DEXERIALS CORPORATION

A phthalocyanine-based complex compound is represented by general formula (1) shown below, 2. The phthalocyanine-based complex compound of having an E1% 1 cm value of at least 300 at a wavelength of maximum absorption in a visible light region.3. The phthalocyanine-based complex compound of claim 1 , whereinthe phthalocyanine-based complex compound dissolves in water or ethylene glycol in an amount of at least 0.01 mass %.4. The phthalocyanine-based complex compound of claim 1 , whereinthe phthalocyanine-based complex compound dissolves as molecules or disperses as particles having a number average particle diameter of no greater than 3 μm in water or ethylene glycol.5. The phthalocyanine-based complex compound of claim 1 , whereinthe phthalocyanine-based complex compound forms a solution having a hydrogen ion concentration (pH) of 4 to 10 when dissolved in water in an amount of 0.1 mass %.6. A method of producing a phthalocyanine-based complex compound claim 1 , for use in producing the phthalocyanine-based complex compound of claim 1 , comprisingpreparing a raw material solution in which a raw material including a phthalocyanine derivative moiety is dissolved in a solvent and a compound solution in which a compound including a moiety that adsorbs onto a metal is dissolved in a solvent, and mixing the raw material solution and the compound solution to precipitate a phthalocyanine-based complex compound.7. The phthalocyanine-based complex compound of claim 2 , whereinthe phthalocyanine-based complex compound dissolves in water or ethylene glycol in an amount of at least 0.01 mass %.8. The phthalocyanine-based complex compound of claim 2 , whereinthe phthalocyanine-based complex compound dissolves as molecules or disperses as particles having a number average particle diameter of no greater than 3 μm in water or ethylene glycol.9. The phthalocyanine-based complex compound of claim 2 , whereinthe phthalocyanine-based complex compound forms a solution having a hydrogen ...

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Номер записи: 81
12-02-2015 дата публикации

Compound, method for producing compound, and method for purifying compound

Номер: US20150045557A1
Автор: Kaoru Noda, Keiichiro Matsuda, Masayuki Matsushita, Satoshi Kajita
Принадлежит: Nippon Soda Co Ltd

The present invention provides a compound characterized by being represented by general formula (I): (wherein, A represents a halogen atom, alkyl group, haloalkyl group, alkoxy group, haloalkoxy group, alkylsulfonyl group, unsubstituted or substituted aryl group, cyano group or nitro group, n represents an integer of 0 to 5 (and A may be mutually the same or different when n is 2 or more), Y represents an alkyl group, M represents an alkaline metal or alkaline earth metal, and m represents an integer of 1 or 2).

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Номер записи: 82
18-02-2021 дата публикации

WATER STABLE COPPER PADDLEWHEEL METAL ORGANIC FRAMEWORK (MOF) COMPOSITIONS AND PROCESSES USING THE MOFS

Номер: US20210046446A1
Автор: Argueta Fajardo Edwin Alfonso, Weston Mitchell Hugh
Принадлежит: NuMat Technologies Inc.

This invention relates to a Cu-BTC MOF which is water stable. The Cu-BTC MOF has been modified by substituting some of the BTC ligand (1,3,5, benzene tricarboxylic acid) with 5-aminoisophthalic acid (AIA). The resultant MOF retains at least 40% of its as synthesized surface area after exposure to liquid water at 60° C. for 6 hours. This is an unexpected result versus the MOF containing only the BTC ligand. This MOF can be used to abate contaminants such as ammonia in gas streams and especially air streams. 1. A metal organic framework (MOF) composition comprising:a coordination product of a copper metal ion and a mixture of organic ligands selected from 1,3,5-benzenetricarboxylic acid (BTC) and 5-aminoisophthalic acid (AIA) the MOF characterized in that it retains at least 40% of its as synthesized surface area after exposure to liquid water at 60° C. for 6 hours.2. The composition of further characterized in that the MOF has an as synthesized Brunauer-Emmett-Teller (BET) surface area of at least 1500 m/g.3. The composition of further characterized in that the MOF has an as synthesized Brunauer-Emmett-Teller (BET) surface area of at least 1700 m/g.4. The composition of further characterized in that the MOF has a gravimetric uptake capacity for ammonia of at least 0.25 g of ammonia per gram of MOF measured at 650 torr and 25° C.5. The composition of where the molar ratio of BTC:AIA varies from about 99:1 to about 1:99.6. The composition of where the molar ratio of BTC:AIA is 1:1.7. The composition of where the molar ratio of BTC:AIA is 1:38. The composition of where the molar ratio of BTC:AIA is: 3:1.9. The composition of claim lwherein it retains at least 50% of its surface area after exposure to liquid water at 60° C. for 6 hours.10. The MOF of further characterized in that the MOF is formed into a shaped body selected from pellets claim 1 , spheres claim 1 , disks claim 1 , monolithic body claim 1 , irregularly shaped particles claim 1 , extrudates claim 1 , and ...

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Номер записи: 83
18-02-2021 дата публикации

WATER STABLE COPPER PADDLEWHEEL METAL ORGANIC FRAMEWORK (MOF) COMPOSITIONS AND PROCESSES USING THE MOFS

Номер: US20210046447A1
Автор: Siu Paul Wai-Man
Принадлежит: NuMat Technologies Inc.

This invention relates to a Cu-BTC MOF which is water stable. The Cu-BTC MOF has open coordination sites and has been post synthesis modified by partially occupying the open sites with a ligand such as acetonitrile (CHCN). The resultant MOF retains at least 40% of its as synthesized surface area after exposure to liquid water at 60° C. for 6 hours. This is an unexpected result versus the MOF which has not been post treated with ligands such as acetonitrile. This MOF can be used to abate contaminants such as ammonia in gas streams and especially air streams. 1. A metal organic framework (MOF) composition comprising:{'sub': '3', 'a coordination product of a copper metal ion and 1,3,5-benzenetricarboxylic acid (BTC) ligand the MOF characterized in that the copper has open coordination sites which are at least partially occupied by acetonitrile (CHCN) and it retains at least 40% of its as synthesized surface area after exposure to liquid water at room temperature for 6 hours.'}2. The composition of further characterized in that the MOF has an as synthesized Brunauer-Emmett-Teller (BET) surface area of at least 1200 m/g.3. The composition of further characterized in that the MOF has a gravimetric uptake capacity for ammonia of at least 0.3 g of ammonia per gram of MOF measured at 675 torr and 25° C.4. The MOF of further characterized in that the MOF has a pore volume of at least 0.5 cc/g.5. The MOF of where the MOF retains at least 50% of its synthesized surface area after exposure to liquid water at room temperature for 6 hours.6. The MOF of further characterized in that the MOF is formed into a shaped body selected from pellets claim 1 , spheres claim 1 , disks claim 1 , monolithic body claim 1 , irregularly shaped particles claim 1 , extrudates claim 1 , and mixtures thereof.7. The MOF of further characterized in that the MOF is deposited as a layer on a support selected from a monolith claim 1 , spherical support claim 1 , ceramic foam claim 1 , woven fabrics claim 1 ...

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Номер записи: 84
06-02-2020 дата публикации

HIGHLY REACTIVE METAL HYDRIDES, PROCESS FOR THEIR PREPARATION AND USE

Номер: US20200040012A1
Автор: Kurth Christopher, Lischka Uwe, Rittmeyer Peter, Scherer Stefan, Stoll Armin, Wietelmann Ulrich
Принадлежит:

The invention relates to powdery, highly reactive alkali and alkaline earth hydride compounds, and to mixtures with elements of the third main group of the periodic table of elements (PTE) and to the preparation thereof by reacting alkali or alkaline earth metals in the presence of finely dispersed metals or compounds of the third main group of the PTE, wherein the latter have one or more hydride ligands or said hydride ligands are converted in situ, under the prevailing reaction conditions, i.e., in the presence of hydrogen gas or another H source, into hydride species, and to the use thereof for the preparation of complex hydrides and organometallic compounds. 1: A method for preparing alkali metal or alkaline earth metal hydrides MHwhere n=1 or 2 corresponding to the valence of the metal M , characterized in that metals M of the first or second periods of the periodic table of elements are reacted with a compound of general formula M[MH]under inert conditions or under hydrogen atmosphere according to{'br': None, 'i': o/', '+p/', '+q/, 'sup': 1', '2', '1', '2, 'sub': x', '3+x', 'b', 'n', 'm, 'M+6M[MH]→MH6MH6M,'}wherein{'sup': '1', 'M=an alkali metal selected from the group consisting of Li, Na, K, Rb, and Cs, or an alkaline earth metal selected from the group consisting of Be, Mg, Ca, Sr, and Ba;'}x=0 or 1;{'sup': '2', 'M=an element of the 3rd main group of the periodic table of elements selected from the group consisting of B, Al, Ga, and In;'}{'sup': '1', 'b=the valence of M;'}{'sup': '1', 'm=1 or 2, corresponding to the valence of the metal M;'}n=1 or 2, corresponding to the valence of the metal M; and for M=alkali element, o and q=2;', 'for M=alkaline earth element, o and q=4; and, 'in the case in which x=0, p=0 [{'sup': '1', 'for M and M=alkali metals, o, p, and q=2;'}, {'sup': '1', 'for M and M=alkaline earth metals, o and p=2, and q=4;'}, {'sup': '1', 'for M=alkali metal and M=alkaline earth metal, o and p=1, and q=2, and'}, {'sup': '1', 'for M=alkaline ...

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Номер записи: 85
15-02-2018 дата публикации

METHOD FOR THE PREPARATION OF METAL-ORGANIC COMPOUNDS

Номер: US20180043330A1
Автор: FRISCIC Tomislav, GIRARD Simon, LI Chao-Jun, MOTTILLO Cristina, NICKELS Christopher Walter
Принадлежит:

A method for the preparation of a metal-organic compound is provided. This method comprises the steps of (a) providing at least one metal precursor, (b) providing at least one bridging organic ligand, and (c) exposing together the metal precursor and the ligand to liquid COor supercritical COas a reaction medium, thereby producing said metal-organic compound. 1. A method for the manufacture of a metal-organic compound , the method comprising the steps of:(a) providing at least one metal precursor,(b) providing at least one bridging organic ligand, and{'sub': 2', '2, '(c) exposing together the metal precursor and the ligand to liquid COor supercritical COas a reaction medium, thereby producing said metal-organic compound.'}2. The method of claim 1 , wherein during step (c) claim 1 , the metal precursor and the ligand are stirred with the liquid COor supercritical CO.3. The method of or claim 1 , wherein during step (c) claim 1 , the metal precursor and the ligand are together exposed to supercritical CO.4. The method of or claim 1 , wherein during step (c) claim 1 , the metal precursor and the ligand are together exposed to liquid CO.5. The method of any one of to claim 1 , wherein step c) is carried out at a temperature ranging between about 0° C. and about 100° C.6. The method of claim 5 , wherein step c) is carried out at a temperature ranging between about 20° C. and about 90° C.7. The method of claim 6 , wherein step c) is carried out at a temperature ranging between about 40° C. and about 80° C.8. The method of claim 7 , wherein step c) is carried out at a temperature ranging between about 50° C. and about 70° C.9. The method of claim 8 , wherein step c) is carried out at a temperature of about 60° C.10. The method of any one of to claim 8 , wherein step c) is carried out at a pressure ranging between about 80 bar and about 140 bar.11. The method of claim 10 , wherein step c) is carried out at a pressure ranging between about 90 bar and about 140 bar.12. The ...

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Номер записи: 86
16-02-2017 дата публикации

Heterodimers of Glutamic Acid

Номер: US20170044098A1
Автор: Craig N. Zimmerman, John W. Babich, Kevin P. Maresca
Принадлежит: Molecular Insight Pharmaceuticals Inc

Compounds of Formula (Ia) wherein R is a C 6 -C 12 substituted or unsubstituted aryl, a C 6 -C 12 substituted or unsubstituted heteroaryl, a C 1 -C 6 substituted or unsubstituted alkyl or —NR′R′, Q is C(O), O, NR′, S, S(O) 2 , C(O) 2 (CH 2 )p Y is C(O), O, NR′S, S(O) 2 , C(O) 2 (CH 2 )p Z is H or C 1- C 4 alkyl, R′ is H, C(O), S(O) 2 , C(O) 2 , a C 6 -C 12 substituted or unsubstituted aryl, a C 6 -C 12 substituted or unsubstituted heteroaryl or a C 1 -C 6 substituted or unsubstituted alkyl, when substituted, aryl, heteroaryl and alkyl are substituted with halogen, C 6 -C 12 heteroaryl, —NR′R′ or COOZ, which have diagnostic and therapeutic properties, such as the treatment and management of prostate cancer and other diseases related to NAALADase inhibition, Radiolabels can be incorporated into the structure through a variety of prosthetic groups attached at the X amino acid side chain via a carbon or hetero atom linkage.

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Номер записи: 87
16-02-2017 дата публикации

Novel complexes for the separation of cations

Номер: US20170044142A1
Автор: Ekaterina Shilova, Pascal Viel, Vincent Huc
Принадлежит: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS, Commissariat a lEnergie Atomique et aux Energies Alternatives CEA, Universite Paris Sud Paris 11

Complexes including a solid support and a material with a matrix structure containing domains complexing rare earth or strategic metals, preparation process thereof and use thereof for extracting or separating the rare earth or strategic metals in an aqueous or organic medium.

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Номер записи: 88
16-02-2017 дата публикации

COPPER COMPOUND, STARTING MATERIAL FOR FORMING THIN FILM, AND METHOD FOR MANUFACTURING THIN FILM

Номер: US20170044188A1
Автор: ENZU Masaki, NISHIDA Akihiro, OKABE Makoto, Sakurai Atsushi, YOSHINO Tomoharu
Принадлежит: ADEKA CORPORATION

This invention provides a copper compound represented by General Formula (I) below. In General Formula (I), Rto Rindependently represent a linear or branched alkyl group with a carbon number of 1 to 5; provided that Rand Rare a methyl group, Rrepresents a linear or branched alkyl group with a carbon number of 2 to 5; and provided that Ris a methyl group and Ris an ethyl group, Rrepresents a methyl group or a linear or branched alkyl group with a carbon number of 3 to 5. A starting material for forming a thin film of the present invention includes the copper compound represented by General Formula (I). The present invention can provide a copper compound which has a low melting point, can be conveyed in a liquid state, has a high vapor pressure, and is easily vaporizable, and also a starting material for forming a thin film which uses such a copper compound. 2. A starting material for forming a thin film claim 1 , comprising the copper compound according to .3. A method for manufacturing a thin film claim 1 , comprising the steps of:{'claim-ref': {'@idref': 'CLM-00002', 'claim 2'}, 'vaporizing the starting material for forming a thin film according to to obtain a vapor including a copper compound; and'}contacting the vapor with a substrate to decompose and/or chemically react the copper compound and then to form a thin film on the substrate. The present invention relates to a copper compound, a starting material for forming a thin film, and a method for manufacturing a thin film that can be used for wiring materials for LSI, electrode materials, and the like.Copper thin films and copper-containing thin films have been used for wiring materials for LSI (Large Scale Integration) and electrode materials because such films exhibit high electric conductivity, high resistance to electromigration, a high melting point, and the like. To manufacture such thin films, flame hydrolysis deposition methods, sputtering methods, ion plating methods, MOD (Metal Organic Decomposition) ...

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Номер записи: 89
16-02-2017 дата публикации

Ruthenium complex, method for producing same, and use of same

Номер: US20170044196A1
Автор: Hideki Nara, Osamu Ogata, Yuji Nakayama
Принадлежит: Takasago International Corp

The present invention provides a novel ruthenium complex that is easy to produce and handle and that can be supplied relatively inexpensively, a method for producing this ruthenium complex, a method for producing alcohols and the like using this ruthenium complex as a catalyst, a method for producing carbonyl compounds using this ruthenium complex as a catalyst, and a method for producing N-alkylamine compounds using this ruthenium complex as a catalyst. The present invention pertains to a ruthenium complex represented by general formula (1) RuX 1 X 2 (PNP) (NHC) m (Solv) n (1) (in general formula (1), X 1 and X 2 each independently represent a monovalent anionic monodentate ligand; PNP represents a tridentate aminodiphosphine ligand, NHC represents an N-heterocyclic carbene derived from a nitrogen-containing heterocyclic ring, and Solv represents a coordinating solvent; and m represents an integer from 1 to 3, n represents an integer from 0 to 2, and 1≦m+n≦3.), a method for producing the same, a catalyst including the same, and methods for producing various organic compounds using this catalyst.

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Номер записи: 90
06-02-2020 дата публикации

LUMINESCENT CYCLOMETALATING TRIDENTATE LIGAND-CONTAINING GOLD(III) COMPOUNDS WITH ARYL AUXILIARY LIGANDS FOR ORGANIC LIGHT-EMITTING DEVICES AND THEIR PREPARATION THEREOF

Номер: US20200044167A1
Автор: Chan Mei Yee, Lee Chin Ho, Li Lok Kwan, Tang Man Chung, YAM Vivian Wing-Wah
Принадлежит:

A novel class of gold(III) compounds containing cyclometalated tridentate ligand and one aryl auxiliary ligand, both coordinated to a gold(III) metal center. 18.-. (canceled)11. The gold(III) compound according to claim 9 , wherein the compound has photoluminescence properties within a range of about 380 to 1050 nm.13. The method according to claim 12 , wherein a luminescent compound is prepared; and/orwherein the gold(III) metal center comprises a light-emitting layer of a light-emitting device; and/orwherein the gold(III) metal group comprises a layer of a light-emitting device; and/orwherein the gold(III) metal compound is a dopant included in the light-emitting layer of the light-emitting device; and/orwherein the gold(III) metal compound is a dopant included in a light-emitting device.14. The method for preparing a luminescent compound according to claim 12 , further comprising:purifying the luminescent compound by any combination of chromatography, extraction, crystallization, and sublimation.15. A light-emitting device having an ordered structure comprising an anode claim 12 , a hole-transporting layer claim 12 , a light-emitting layer claim 12 , an electron-transporting layer and a cathode claim 12 , wherein the light-emitting layer comprises a luminescent compound prepared according to the method of .16. The light-emitting device of wherein the light-emitting layer is prepared using vacuum deposition or solution processing technique.18. The light-emitting device of wherein the light-emitting layer is prepared using vacuum deposition or solution processing technique.19. The light-emitting device of claim 17 , wherein the gold(III) compound has photoluminescence properties within a range of about 380 to 1050 nm. Embodiments of the invention are related to the design and synthesis of a novel class of gold(III) compounds containing cyclometalated tridentate ligand and one aryl auxiliary ligand. These emitters can be fabricated by vacuum deposition or solution ...

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Номер записи: 91
25-02-2016 дата публикации

METHOD FOR CONTROLLING PARTICLE SIZE OF SILVER PARTICLES, SILVER PARTICLES, ANTIMICROBIAL AGENT CONTAINING SLIVER PARTICLES, AND USE THEREOF

Номер: US20160050935A1
Автор: Furuzono Tsutomu, Kawabe Karl Kazushige, Kogai Yasumichi
Принадлежит:

Silver particles are prepared by aggregating silver ions in accordance with a method including steps of (a), in preparing a mixed solution by adding a thiol compound to a solution containing silver ions, adjusting an amount of the thiol compound added to the solution and (b) adding a reducing agent to the mixed solution. This allows a particle size and antibacterial activity of the silver particles to be easily adjusted. 1. A method of controlling a particle size of silver particles prepared by aggregating silver ions , the method comprising the steps of:in preparing a mixed solution by adding a thiol compound to a solution containing silver ions, adjusting an amount of the thiol compound added to the solution, the thiol compound being represented by a chemical formula HS—R-A (where R is any organic group, and A is any reactive functional group); andadding a reducing agent to the mixed solution.2. The method as set forth in claim 1 , wherein a molarity of the thiol compound and a molarity of the silver ions of the mixed solution are adjusted so that the molarity of the thiol compound/the molarity of the silver ions≧1/1000.3. The method as set forth in claim 1 , wherein the organic group R is an alkane claim 1 , an alkene claim 1 , or an alkyne.4. The method as set forth in any one of claim 1 , wherein the reactive functional group A is a carboxyl group claim 1 , a sulphonyl group claim 1 , a phosphate group claim 1 , an alkoxysilyl group claim 1 , a carboxylic acid anhydride claim 1 , an amino group claim 1 , or a hydroxyl group.5. Silver particles comprising a chemically-modifying group represented by a chemical formula S—R-A (where R is any organic group claim 1 , and A is any reactive functional group) claim 1 , the chemically-modifying group binding to at least part of a surface of particles containing silver.6. The silver particles as set forth in claim 5 , wherein the organic group R is an alkane claim 5 , an alkene claim 5 , or an alkyne.7. The silver ...

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Номер записи: 92
25-02-2016 дата публикации

BIMODAL LIGANDS WITH MACROCYCLIC AND ACYCLIC BINDING MOIETIES, COMPLEXES AND COMPOSITIONS THEREOF, AND METHODS OF USING

Номер: US20160052894A1
Автор: Chong Hyun-Soon
Принадлежит:

Substituted 1,4,7-triazacyclononane-N,N′,N″-triacetic acid and 1,4,7,10-tetraazacycicododecane-N,N′,N″,N′″-tetraacetic acid compounds with a pendant amino or hydroxyl group, metal complexes thereof, compositions thereof, and methods of making and use in diagnostic imaging and treatment of cellular disorders. 2. A complex comprising the compound of and a metal ion claim 1 , a radioactive isotope of the metal ion claim 1 , or a radioactive isotope of carbon claim 1 , nitrogen claim 1 , iodine claim 1 , fluorine claim 1 , oxygen claim 1 , or helium.3. A conjugate comprising the complex of and a targeting moiety claim 2 , a fluorescence moiety claim 2 , or a nanoparticle.4. The complex of claim 2 , wherein the metal ion is selected from the group consisting of Ac claim 2 , Al claim 2 , Bi claim 2 , Pb claim 2 , Y claim 2 , Mn claim 2 , Cr claim 2 , Fe claim 2 , Co claim 2 , Zn claim 2 , Ni claim 2 , Tc claim 2 , Gd claim 2 , In claim 2 , Ga claim 2 , Cu claim 2 , Re claim 2 , Sm claim 2 , Pm claim 2 , Ho claim 2 , Zr claim 2 , Ra claim 2 , Sr claim 2 , Cs claim 2 , Th claim 2 , Am claim 2 , U claim 2 , an alkali metal claim 2 , an alkaline earth metal claim 2 , a transition metal claim 2 , a lanthanide claim 2 , and an actinide.5. A conjugate comprising the complex of and a targeting moiety claim 4 , a fluorescence moiety claim 4 , or a nanoparticle.6. A conjugate comprising the compound of and a targeting moiety claim 1 , a fluorescence moiety claim 1 , a ligand claim 1 , or a nanoparticle.7. The conjugate according to claim 6 , comprising the targeting moiety claim 6 , wherein the targeting moiety comprises a biomolecule selected from a hormone claim 6 , a bile acid claim 6 , an amino acid claim 6 , a peptide claim 6 , a peptidomimetic claim 6 , a protein claim 6 , a deoxyribonucleic acid (DNA) claim 6 , a ribonucleic acid (RNA) claim 6 , a lipid claim 6 , an albumin claim 6 , a receptor molecule claim 6 , a receptor binding molecule claim 6 , a hapten claim 6 , a ...

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Номер записи: 93
25-02-2016 дата публикации

ORGANIC ANION LITHIUM IONIC COCRYSTAL COMPOUNDS AND COMPOSITIONS

Номер: US20160052941A1
Автор: DUGGIRALA Naga, SHYTLE ROLAND DOUGLAS, Smith Adam John, ZAWOROTKO Michael John
Принадлежит: UNIVERSITY OF SOUTH FLORIDA

A cocrystal having the formula LiX.aM, or a solvate or hydrate thereof, wherein X is a conjugate base of an organic acid, M is a neutral organic molecule, and a is from 0.5 to 4, pharmaceutical compositions comprising such cocrystals, cocrystal solvates, or cocrystal hydrates, and methods of preparing such cocrystals, cocrystal solvates, or cocrystal hydrates, and such pharmaceutical compositions. 1. A cocrystal having the formula LiX.aM , or a solvate or hydrate thereof , wherein X is a conjugate base of an organic acid , M is a neutral organic molecule , and a is from 0.5 to 4.2. The cocrystal claim 1 , solvate or hydrate of wherein M is an amino acid.3. The cocrystal claim 1 , solvate or hydrate of wherein M is leucine.4. The cocrystal claim 1 , solvate or hydrate of wherein M is a neutral zwitterionic compound claim 1 , a xanthine claim 1 , a polyphenol claim 1 , or a flavonoid.5. The cocrystal claim 1 , solvate or hydrate of wherein X is acetate claim 1 , adipate claim 1 , diacetate claim 1 , alginate claim 1 , aminosalicylate claim 1 , anhydromethylenecitrate claim 1 , arecoline claim 1 , arginine claim 1 , ascorbate claim 1 , asparatete claim 1 , benzenesulfonate (benzene) claim 1 , benzoate claim 1 , bicarbonate claim 1 , bisulfate claim 1 , bitartrate claim 1 , butylbromide claim 1 , butyrate claim 1 , calcium edentate claim 1 , calcium edentate claim 1 , camphorate claim 1 , camsylate (camphorsulfonate) claim 1 , citrate claim 1 , dihydrochloride claim 1 , edentate claim 1 , edisylate (1 claim 1 ,2-ethanedisulfonate) claim 1 , estolate (lauryl sulfate) claim 1 , esylate (ethanesulfonate) claim 1 , fumarate claim 1 , gluceptate (glucoheptonate) claim 1 , gluconate claim 1 , digluconate claim 1 , glucuronate claim 1 , glutamate claim 1 , glycerophosphate claim 1 , glucollylarsanilate (p-glycollamidophenylarsonate) claim 1 , hexylresorcinate claim 1 , hydrabamine (N claim 1 ,N′-di(dehydroabietyl)ethylenediamine) claim 1 , hydroxynaphthoate claim 1 , ...

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Номер записи: 94
25-02-2021 дата публикации

BROMINATION OF PYRIDINE DERIVATIVES

Номер: US20210053991A1
Автор: Mueller Bernd, Rack Michael
Принадлежит:

The present invention relates to a process for the preparation pyridine derivatives of the formula (I). 2. The process according to claim 10 , wherein the brominating agent is 1 claim 10 ,3-dibromo-5 claim 10 ,5-dimethylhydantoin (DBDMH).3. The process according to claim 1 , wherein Rand Rare hydrogen claim 1 , and Ris C-C-alkyl4. The process according to claim 1 , wherein Rand Rare hydrogen and Ris CH.6. The process according to claim 5 , wherein Rand Rare hydrogen claim 5 , Rand Ris C-C-alkyl claim 5 , Rand Rare halogen claim 5 , Rand Rform a phenyl claim 5 , o is 0 and Ris C-C-alkyl.7. The process according to claim 5 , wherein Rand Rare hydrogen claim 5 , Rand Rare CH claim 5 , Rand Rare F claim 5 , Rand Rform a phenyl claim 5 , o is 0 and Ris CH.8. The process according to claim 5 , wherein X is selected from the group consisting of Li claim 5 , Na claim 5 , K claim 5 , and Cs.10. The compound according to claim 9 , wherein if{'sup': 1', '2, 'Ris H and Ris halogen;'}{'sup': '10', 'sub': 3', '2', '2, 'Ris CH, CHCl and CHBr; and'}if{'sup': 1', '2, 'Ris H and Ris H;'}{'sup': '10', 'sub': 2', '2', '3', '2', '3', '2, 'Ris CHF, CHCH, CHCH(CH).'}11. The process according to wherein the brominating agent is selected from the group consisting of N-bromosuccinimide (NBS) claim 1 , 1 claim 1 ,3-dibromo-5 claim 1 ,5-dimethylhydantoin (DBDMH) claim 1 , and a system consisting of HBr/HOin the presence of oleum 65%. The present invention relates to a process for the preparation pyridine derivatives of the formula IBromination of similar pyridine derivatives is known from US 20140194386 and WO 2008/070740. One of the disadvantages of the reactions described in the above mentioned documents lies in the use of bromine in the presence of fuming sulfuric acid.From Z. Chem 1988 28 2 50 a bromination is known using 65% oleum and Br. One of the disadvantages of the use of Bras brominating agent is that the reaction is very slow and requires high temperatures. Furthermore, the use of ...

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Номер записи: 95
13-02-2020 дата публикации

Process for preparing a 5-alken-1-yne compound, (6z)-1,1-dialkoxy-6-nonen-2-yne compound, (2e,6z)-2,6-nonadienal and (2e)-cis-6,7-epoxy-2-nonenal, and 1,1-dialkoxy-6-nonen-2-yne compound

Номер: US20200048161A1
Автор: Takeshi Kinsho, Tomohiro Watanabe, Yuki Miyake
Принадлежит: Shin Etsu Chemical Co Ltd

The object of the present invention is to provide a process for preparing a 5-alken-1-yne compound efficiently at low costs and a process for preparing (2E,6Z)-2,6-nonadienal by making use of the aforesaid process for preparing the 5-alken-1-yne compound. There is provided a process for preparing a 5-alken-1-yne compound of the following formula (4): Y-Z-CR 1 ═CR 2 —(CH 2 ) 2 —C≡CH (4) in which Y in formula (4) represents a hydrogen atom or a hydroxyl group, the process comprising at least steps of: subjecting (i) an alkenylmagnesium halide compound prepared from a haloalkene compound of the following formula (1): Y-Z-CR 1 ═CR 2 —(CH 2 ) 2 -X 1 (1) and (ii) an alkyne compound of the following formula (2): X 2 =C≡C—Si(R 3 )(R 4 )(R 5 ) (2) to a coupling reaction to form a silane compound of the following formula (3): Y-Z-CR 1 ═CR 2 —(CH 2 ) 2 —C≡C—Si(R 3 )(R 4 )(R 5 ) (3); and subjecting the silane compound (3) to a desilylation reaction to form the 5-alken-1-yne compound (4).

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Номер записи: 96
23-02-2017 дата публикации

Molecular Imaging Probes

Номер: US20170050989A1
Автор: Caravan Peter
Принадлежит:

This disclosure relates to compounds of formula (I) shown below: [formula (I)], or a pharmaceutically acceptable salt thereof. These compounds can be used as imaging probes, e.g., for diagnosis of fibrosis or fibrogenesis. 2. The compound of claim 1 , wherein the first complexing group is a DOTA claim 1 , NOTA claim 1 , DO3AX claim 1 , DO3AP claim 1 , DOTP claim 1 , DO2A2P claim 1 , NOTP claim 1 , NO2AP claim 1 , NO2PA claim 1 , TETA claim 1 , TE2P claim 1 , TE2A claim 1 , TE1A1P claim 1 , CBTE2P claim 1 , CBTE1A1P claim 1 , SBTE2A claim 1 , SBTE1A1P claim 1 , DTTP claim 1 , CHX-A″-DTPA claim 1 , Desferal claim 1 , HBED claim 1 , PyDO3P claim 1 , PyDO2AP claim 1 , PyDO3A claim 1 , DIAMSAR claim 1 , EDTA claim 1 , DTP A claim 1 , CB-TE2A claim 1 , SarAr claim 1 , PCTA claim 1 , pycup claim 1 , DEDPA claim 1 , OCTAPA claim 1 , AAZTA claim 1 , DOTAIa claim 1 , CyPic3 A claim 1 , TRAP claim 1 , NOPO claim 1 , or CDTA moiety.3. The compound of claim 1 , wherein the metal ion is selected from Gd claim 1 , Mn claim 1 , Mn claim 1 , Fe claim 1 , Ce claim 1 , Pr claim 1 , Nd claim 1 , Eu claim 1 , Eu claim 1 , Tb claim 1 , Dy claim 1 , Er claim 1 , Ho claim 1 , Tm claim 1 , Yb claim 1 , and Cr claim 1 , or is an ion of a radioisotope selected from the group consisting of Ga claim 1 , Ga claim 1 , Al-F claim 1 , 64Cu claim 1 , In claim 1 , Mn claim 1 , Zr claim 1 , Y claim 1 , Tl claim 1 , Tc claim 1 , and Tc.4. The compound of claim 1 , wherein X is —C(RR)— claim 1 , —C(S)— claim 1 , or —C(O)— claim 1 , in which each of Rand R claim 1 , independently claim 1 , is H claim 1 , C-Calkyl claim 1 , C-Calkenyl claim 1 , C-Calkynyl claim 1 , or aryl.5. (canceled)6. The compound of claim 1 , wherein Y is —N(R)— or —O— claim 1 , in which Ris H claim 1 , C-Calkyl claim 1 , C-Calkenyl claim 1 , C-Calkynyl claim 1 , or aryl.7. (canceled)8. The compound of claim 1 , wherein L is —(CH)— claim 1 , —NH(CH)— claim 1 , or —(CH)—aryl- claim 1 , in which n is 1 claim 1 , 2 claim 1 , or 3.9. ( ...

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Номер записи: 97
23-02-2017 дата публикации

Organic Electroluminescent Materials and Devices

Номер: US20170054090A1
Автор: Boudreault Pierre-Luc T., Xia Chuanjun
Принадлежит:

This invention discloses iridium complexes with benzothienoquinoline, benzofuroquinoline, benzoselenophenoquinoline, and benzosiloloquinoline ligands. These complexes can be used as phosphorescent emitters in OLEDs. 2. The compound of claim 1 , wherein M is selected from the group consisting of Ir claim 1 , Rh claim 1 , Re claim 1 , Ru claim 1 , Os claim 1 , Pt claim 1 , Au claim 1 , and Cu.3. (canceled)4. The compound of claim 1 , wherein the compound has the formula selected from the group consisting of M(L)(L) and M(L)(L).5. (canceled)6. The compound of claim 1 , wherein Yto Yare carbon.7. The compound of claim 1 , wherein only one of Yto Yis nitrogen.910-. (canceled)11. The compound of claim 1 , wherein ring C is benzene claim 1 , and ring D is pyridine of which Yis N.1517-. (canceled)22. The OLED of claim 21 , wherein the OLED is incorporated into a device selected from the group consisting of a consumer product claim 21 , an electronic component module claim 21 , and a lighting panel.23. The OLED of claim 21 , wherein the organic layer is an emissive layer and the compound is an emissive dopant or a non-emissive dopant.24. (canceled)25. The OLED of claim 21 , wherein the organic layer further comprises a host claim 21 ,wherein the host comprises at least one chemical group selected from the group consisting of triphenylene, carbazole, dibenzothiophene, dibenzofuran, dibenzoselenophene, azatriphenylene, azacarbazole, aza-dibenzothiophene, aza-dibenzofuran, and aza-dibenzoselenophene.27. The OLED of claim 21 , wherein the organic layer further comprises a host claim 21 , wherein the host comprises a metal complex. This application claims priority from U.S. Provisional Patent Application Ser. No. 62/206,325 filed Aug. 18, 2015, the entire contents of which is incorporated herein by reference.The claimed invention was made by, on behalf of, and/or in connection with one or more of the following parties to a joint university corporation research agreement: The ...

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Номер записи: 98
04-03-2021 дата публикации

THIN-FILM COMPOSITE POLYAMIDE REVERSE OSMOSIS MEMBRANE WITH ANTI-BACTERIAL AND ANTI-BIOFOULING EFFECTS AND PREPARATION METHOD THEREOF

Номер: US20210060497A1
Автор: CHEN Yingqing, WANG JIE, Wang Zhiwei, WEN Yue, WU Zhichao, Zhang Hongwei
Принадлежит:

A thin-film composite polyamide reverse osmosis membrane with anti-bacterial and anti-biofouling effects and a preparation method thereof are disclosed. The preparation method includes: dissolving a highly water-stable metal organic framework CuBTTri in an n-hexane solution containing trimesoyl chloride by ultrasonic wave, immersing a polyethersulfone ultrafiltration membrane in an aqueous solution of m-phenylene diamine and taking out, and then immersing the ultrafiltration membrane in the trimesoyl chloride-n-hexane solution containing the aforementioned metal organic framework for reaction and modification, so as to obtain the thin-film composite polyamide reverse osmosis membrane. The resulting composite reverse osmosis membrane integrated with the anti-bacterial metal organic framework CuBTTri has a high reverse osmosis membrane permeability and possesses greatly improved and persistent anti-bacterial and anti-biofouling properties. The preparation method is simple and conducive to promotion, and has mild conditions. 2. A thin-film composite polyamide reverse osmosis membrane with anti-bacterial and anti-biofouling effects claim 1 , comprising a substrate and a thin film; wherein the substrate is an ultrafiltration membrane claim 1 , and the thin film is formed by loading an aromatic polyamide film containing the CuBTTri of uniformly on a surface of the substrate.3. The thin-film composite polyamide reverse osmosis membrane with the anti-bacterial and anti-biofouling effects of claim 2 , wherein the ultrafiltration membrane comprises at least one of a polyacrylonitrile membrane claim 2 , a polysulfone membrane and a polyethersulfone membrane claim 2 , and the ultrafiltration membrane has a molecular weight cutoff of 10-20 kDa.4. A method for preparing the thin-film composite polyamide reverse osmosis membrane with the anti-bacterial and anti-biofouling effects of claim 2 , comprising the steps of:i) synthesizing the CuBTTri, comprising the steps in order of:{' ...

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Номер записи: 99
01-03-2018 дата публикации

ORGANIC ANION LITHIUM IONIC COCRYSTAL COMPOUNDS AND COMPOSITIONS

Номер: US20180057511A1
Автор: DUGGIRALA Naga, SHYTLE ROLAND DOUGLAS, Smith Adam John, ZAWOROTKO Michael John
Принадлежит: UNIVERSITY OF SOUTH FLORIDA

A cocrystal having the formula LiX.aM, or a solvate or hydrate thereof, wherein X is a conjugate base of an organic acid, M is a neutral organic molecule, and a is from 0.5 to 4, pharmaceutical compositions comprising such cocrystals, cocrystal solvates, or cocrystal hydrates, and methods of preparing such cocrystals, cocrystal solvates, or cocrystal hydrates, and such pharmaceutical compositions. 1. A cocrystal having the formula LiX.aM , or a solvate or hydrate thereof , wherein X is a conjugate base of an organic acid , M is a neutral organic molecule.2. The cocrystal claim 1 , solvate or hydrate of wherein a is from 0.5 to 43. The cocrystal claim 1 , solvate or hydrate of wherein M is a neutral zwitterionic compound claim 1 , a xanthine claim 1 , a polyphenol claim 1 , a flavonoid claim 1 , or an amino acid.4. The cocrystal claim 1 , solvate or hydrate of wherein X is acetate claim 1 , adipate claim 1 , diacetate claim 1 , alginate claim 1 , aminosalicylate claim 1 , anhydromethylenecitrate claim 1 , arecoline claim 1 , arginine claim 1 , ascorbate claim 1 , asparatete claim 1 , benzenesulfonate (benzene) claim 1 , benzoate claim 1 , bicarbonate claim 1 , bisulfate claim 1 , bitartrate claim 1 , butylbromide claim 1 , butyrate claim 1 , calcium edentate claim 1 , calcium edentate claim 1 , camphorate claim 1 , camsylate (camphorsulfonate) claim 1 , citrate claim 1 , dihydrochloride claim 1 , edentate claim 1 , edisylate (1 claim 1 ,2-ethanedisulfonate) claim 1 , estolate (lauryl sulfate) claim 1 , esylate (ethanesulfonate) claim 1 , fumarate claim 1 , gluceptate (glucoheptonate) claim 1 , gluconate claim 1 , digluconate claim 1 , glucuronate claim 1 , glutamate claim 1 , glycerophosphate claim 1 , glucollylarsanilate (p-glycollamidophenylarsonate) claim 1 , hexylresorcinate claim 1 , hydrabamine (N claim 1 , N′-di(dehydroabietyl)ethylenediamine) claim 1 , hydroxynaphthoate claim 1 , isethionate (2-hydroxyethanesulfonate) claim 1 , lactate claim 1 , lactobionate ...

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Номер записи: 100