Method for the manufacture of aminopolyalkylene phosphonic acids

A method for the manufacture of aminopolyalkylene phosphonic acid of a specific general formula is described. In particular, a mixture of specifically defined ranges of reactants to wit: phosphorous acid; an amine; formaldehyde and an aminopolyalkylene phosphonic acid, having the same general formula as the compound to be manufactured, are reacted to thus yield a product of outstanding selectivity and purity with substantially reduced levels of non-desirable by-products.

Production of catalytically active activated carbons

The invention is directed to a method for preparing catalytically active activated carbon, to catalytically active activate carbon obtainable by the method, and to the use of the catalytically active activated carbon. The method of the invention method comprises the steps of: i) mixing charcoal with one or more organic nitrogen-containing compounds, said nitrogen-containing compounds comprising, next to a first nitrogen atom, at least two or more further heteroatoms selected from the group consisting of nitrogen and oxygen, wherein said further heteroatoms have a lone pair; ii) drying the mixture obtained in step i); iii) activating the dried mixture using steam, thereby producing catalytically active activated carbon.

QUATERNARY AMMONIUM SALTS AS INHIBITORS OF TRIMETHYLAMINE PRODUCTION

Provided are compounds that can inhibit pathogenic, bacterial metabolite production and conjugates of the same. Also provided are pharmaceutical compositions comprising the same and methods of using the same. 5. The compound of claim 4 , wherein Ris Calkyl substituted with —O-(acylated sugar) and is optionally further substituted with oxo.6. The compound of or claim 4 , wherein Ris methyl.7. The compound of any one of claim 4 , claim 4 , and claim 4 , wherein Ris Calkyl.8. The compound of any one of - claim 4 , wherein Ris propargyl.9. The compound of claim 4 , wherein{'sup': '1', 'sub': '2-6', 'Ris Calkyl substituted with —O-(acylated sugar) and is optionally further substituted with oxo;'}{'sup': '2', 'Ris methyl;'}{'sup': '3', 'sub': '1-6', 'Ris Calkyl; and'}{'sup': '4', 'Ris propargyl.'}10. The compound of claim 4 , wherein{'sup': '1', 'sub': '2-6', 'Ris Calkyl substituted with isosorbide and is optionally further substituted with oxo and/or methene;'}{'sup': '2', 'Ris methyl;'}{'sup': '3', 'sub': '1-6', 'Ris Calkyl; and'}{'sup': '4', 'Ris propargyl.'}13. The compound of claim 4 , wherein{'sup': '1', 'sub': 3-4', '1-2, 'Ris Ccycloalkyl Calkyl;'}{'sup': '2', 'sub': '2-6', 'Ris Calkyl optionally substituted with one or two hydroxyl, oxo, and —O-(acylated sugar);'}{'sup': 1', '2', 's', 's, 'sub': 2', 'n, 'or Rand R, together with the nitrogen atom to which both are attached, combine to form a 4- or 5-membered heterocyclic ring optionally substituted with ethynyl or —(CH)—ORor an acylated sugar, wherein n is 0 or 1, Ris hydrogen or an acylated sugar;'}{'sup': '3', 'sub': '1-6', 'Ris Calkyl optionally substituted with a halogen or hydroxyl; and'}{'sup': '4', 'sub': '1-6', 'Ris Calkyl or propargyl.'}14. The compound of claim 13 , wherein Ris Ccycloalkyl Calkyl.15. The compound of or claim 13 , wherein Ris Calkyl optionally substituted with one or two hydroxyl groups.16. The compound of claim 13 , wherein Rand R claim 13 , together with the nitrogen atom to which both ...

Biological buffers with wide buffering ranges

Amines and amine derivatives that improve the buffering range, and/or reduce the chelation and other negative interactions of the buffer and the system to be buffered. The reaction of amines or polyamines with various molecules to form polyamines with differing pKa's will extend the buffering range, derivatives that result in polyamines that have the same pKa yields a greater buffering capacity. Derivatives that result in zwitterionic buffers improve yield by allowing a greater range of stability.

1,3,4-OXADIAZOLES-2-THIO DERIVATIVES AS SPHINGOSINE-1 PHOSPHATE RECEPTORS MODULATORS

The present invention relates to substituted 1,3,4-oxadiazoles-2-thio derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of sphingosine-1-phosphate receptors. 5. A compound according to selected from:3-{[4-(1-{[5-(3,4-Dimethylphenyl)-1,3,4-oxadiazol-2-yl]thio}ethyl)benzyl]amino}propanoic acid;(3-{[4-(1-{[5-(3,4-Dimethylphenyl)-1,3,4-oxadiazol-2-yl]thio}ethyl)benzyl]amino}propyl)phosphonic acid; and(3-{[4-({[5-(3,4-Dimethylphenyl)-1,3,4-oxadiazol-2-yl]thio}methyl)benzyl]amino}propyl)phosphonic acid.6. A pharmaceutical composition comprising as active ingredient a therapeutically effective amount of a compound according to and a pharmaceutically acceptable adjuvant claim 1 , diluent or carrier.7. A pharmaceutical composition according to wherein the compound is selected from:3-{[4-(1-{[5-(3,4-Dimethylphenyl)-1,3,4-oxadiazol-2-yl]thio}ethyl)benzyl]amino}propanoic acid;(3-{[4-(1-{[5-(3,4-Dimethylphenyl)-1,3,4-oxadiazol-2-yl]thio}ethyl)benzyl]amino}propyl)phosphonic acid; and(3-{[4-({[5-(3,4-Dimethylphenyl)-1,3,4-oxadiazol-2-yl]thio}methyl)benzyl]amino}propyl)phosphonic acid.9. A method of claim 8 , wherein the pharmaceutical composition is administered to the mammal to treat ocular diseases claim 8 , wet and dry age-related macular degeneration claim 8 , diabetic retinopathy claim 8 , retinopathy of prematurity claim 8 , retinal edema claim 8 , geographic atrophy claim 8 , glaucomatous optic neuropathy claim 8 , chorioretinopathy claim 8 , hypertensive retinopathy claim 8 , ocular ischemic syndrome claim 8 , prevention of inflammation-induced fibrosis in the back of the eye claim 8 , various ocular inflammatory diseases including uveitis claim 8 , scleritis claim 8 , keratitis claim 8 , and retinal vasculitis; or systemic vascular barrier related diseases claim 8 , various inflammatory diseases claim 8 , including acute lung injury claim 8 , its prevention claim 8 , sepsis claim 8 , tumor ...

PHOSPHORUS FUNCTIONAL ANTIMICROBIAL COATINGS FOR METAL SURFACES

The invention relates to quaternary ammonium multi-dentate mono-, bis-, tris- and tetrakis-phosphonate compounds, processes for preparing quaternary ammonium multi-dentate mono-, bis-, tris- and tetrakis-phosphonate compounds, antimicrobial coating compositions comprising quaternary ammonium multi-dentate mono-, bis-, tris- and tetrakis-phosphonate compounds and method of treating a surface with said compositions to provide a durable, antimicrobial-treated surface. 1150.-. (canceled)152. The process of wherein Rand Rare methyl.153. The process of wherein R is ethyl.154. The process of wherein n is 1 or 2.155. The process of wherein m is 17.156. The process of wherein R claim 151 , Rand Rare the same and methyl.157. The process of wherein Z is chloro or triflate.158. The process of wherein X is bromo.160. The process of wherein R is the same and ethyl.161. The process of wherein Rand Rare methyl.162. The process of wherein n is 1 or 2.163. The process of wherein m is 17.164. The process of wherein Z is bromo.165. The process of wherein the alkali carbonate is potassium carbonate.167. The process of wherein R is the same and ethyl.168. The process of wherein n is 1 or 2.169. The process of wherein the polar claim 166 , aprotic solvent is selected from the group consisting of acetonitrile claim 166 , dimethylformamide and dichloromethane.171. The process of wherein R is ethyl.172. The process of wherein Rand Ris methyl.173. The process of wherein n is 1 or 2.174. The process of wherein p is 1 or 2.175. The process of wherein Z is bromo.176. The process of wherein the polar claim 170 , aprotic solvent is selected from the group consisting of acetonitrile claim 170 , dimethylformamide and dichloromethane.178. The coating composition of wherein: in formula (I) claim 177 , Rand Rare methyl claim 177 , in is 17 claim 177 , n is 1 or 2 and X is bromo; and in formulas (XIV) and (XXVIII) claim 177 , R is the same and hydrogen claim 177 , Rand Rare methyl claim 177 , in is 17 ...

Metal utilization in supported, metal-containing catalysts

Generally, the present invention relates to improvements in metal utilization in supported, metal-containing catalysts. For example, the present invention relates to methods for directing and/or controlling metal deposition onto surfaces of porous substrates. The present invention also relates to methods for preparing catalysts in which a first metal is deposited onto a support (e.g., a porous carbon support) to provide one or more regions of a first metal at the surface of the support, and a second metal is deposited at the surface of the one or more regions of the first metal. Generally, the electropositivity of the first metal (e.g., copper or iron) is greater than the electropositivity of the second metal (e.g., a noble metal such as platinum) and the second metal is deposited at the surface of the one or more regions of the first metal by displacement of the first metal. The present invention further relates to treated substrates, catalyst precursor structures and catalysts prepared by these methods. The invention further relates to use of catalysts prepared as detailed herein in catalytic oxidation reactions, such as oxidation of a substrate selected from the group consisting of N-(phosphonomethyl)iminodiacetic acid or a salt thereof, formaldehyde, and/or formic acid.

Biological Buffers with Wide Buffering Ranges

Amines and amine derivatives that improve the buffering range, and/or reduce the chelation and other negative interactions of the buffer and the system to be buffered. The reaction of amines or polyamines with various molecules to form polyamines with differing pKa's will extend the buffering range, derivatives that result in polyamines that have the same pKa yields a greater buffering capacity. Derivatives that result in zwitterionic buffers improve yield by allowing a greater range of stability. 2. The biological buffer and its salts of wherein A═D═—CH3 and m=1.3. The biological buffer and its salts of wherein A═D═—CH2OH and m=1.4. The biological buffer and its salts of wherein A═D—CH2O(CH2CH2CH2N)H and n=m=1.5. The biological buffer and its salts of wherein A═—CH2CH3 claim 1 , D═—CH2O(CH2CH2CH2N)H and n=m=1.6. The biological buffer and its salts of wherein A═—CH3 claim 1 , D═—CH2O(CH2CH2CH2N)H and n=m=1.7. The biological buffer and its salts of wherein A is —CH3 and D is —CH2CH3.9. The quaternary ammonium compound and its salts of wherein A═D═—CH3 claim 8 , E═—CH2OH claim 8 , R═R′═—CH3 and G═—H.10. The quaternary ammonium compound and its salts of wherein A═D═E═—CH2OH claim 8 , R═R′═—CH3 and G═—H.11. The quaternary ammonium compound and its salts of wherein A═D═—CH3 claim 8 , E═—CH2OH claim 8 , R═R′═—CH3 and G═—CH2CH3.12. The quaternary ammonium compound and its salts of wherein A═D═E═—CH2OH claim 8 , R═R′=—CH3 and G═—CH2CH3. This is a continuation of U.S. application Ser. No. 15/649,869 filed Jul. 14, 2017 and other previous parent applications claimed in the Application Data Sheet. U.S. application Ser. No. 15/649,869 is hereby incorporated by reference in its entirety.The present invention relates generally to the field of amines and more particularly to a classes of amines used as buffers in biological systems.Amines are very useful compounds in the buffering of biological systems. Each class of amine has various limitations which require choosing an amine ...

NOVEL DIAMINE COMPOUND AND METAL COMPLEXES, AND METHOD FOR PRODUCING OPTICALLY ACTIVE COMPOUNDS

The present invention relates to a novel diamine compound represented by the general formula (1), a ruthenium-diamine complex, an iridium-diamine complex, and a rhodium-diamine complex having the diamine compound as a ligand. Furthermore, the present invention relates to methods for selectively producing optically active compounds by using any of these complexes as a catalyst. 3. A method for producing an optically active amine or an optically active compound , comprising:{'claim-ref': {'@idref': 'CLM-00002', 'claim 2'}, 'reducing an imino group of an imine compound or an unsaturated bond of a heterocyclic compound in the presence of the complex according to and a hydrogen donor.'}4. The production method according to claim 3 , wherein the hydrogen donor is hydrogen.5. The production method according to claim 3 , wherein the hydrogen donor is selected from formic acid claim 3 , alkali metal formates claim 3 , and alcohols having a hydrogen atom on a carbon atom at an α-position of a carbon atom substituted with a hydroxyl group.6. A catalyst for asymmetric reduction claim 2 , comprising the complex according to .7. A method for asymmetric reduction of an imine compound or a heterocyclic compound comprising: reducing an imino group of the imine compound or an unsaturated bond of the heterocyclic compound in the presence of a catalyst comprising the complex according to and a hydrogen doner. The present invention relates to a novel diamine compound, a ruthenium-diamine complex, an iridium-diamine complex, and a rhodium-diamine complex having the diamine compound as a ligand, and methods for selectively producing optically active compounds important as precursors for synthesis of pharmaceuticals and functional materials by using any of these complexes as a catalyst.In the field of production of optically active amines, many asymmetric reactions including asymmetric reduction have been developed, and many asymmetric reactions using asymmetric metal complexes having ...

Optically-active 2-amino-phosphonoalkane acid, optically-active 2-amino-phosphonoalkane acid salt, and hydrates of these

A novel compound has pharmacological activities comparable to those of Nahlsgen and is storable excellently stably. The compound can be produced by a method according to the present invention for producing an optically active 2-amino-phosphonoalkanoic acid salt. In the method, a starting material DL-2-amino-phosphonoalkanoic acid represented by Formula (1) or a hydrate thereof is reacted with an optically active basic compound other than an optically active lysine, to give a diastereomeric salt mixture including a first salt (including a hydrate salt) between a D-2-amino-phosphonoalkanoic acid represented by Formula (1-1) and the optically active basic compound, and a second salt (including a hydrate salt) between an L-2-amino-phosphonoalkanoic acid represented by Formula (1-2) and the optically active basic compound. The diastereomeric salt mixture is fractionally crystallized to isolate one of the first and second diastereomeric salts.

N-PHOSPHONOMETHYLGLYCINE GUANIDINE DERIVATIVE SALTS

The present invention provides guanidine compounds and salts thereof that may be useful, for example, in the preparation of herbicidal compositions. The compounds may be used, for example, to prepare N-phosphonomethylglycine guanidine salts having improved herbicidal efficacy over glyphosate alone. 2. The compound of wherein R claim 1 , R claim 1 , Rand Rare independently hydrogen or C-Calkyl.3. The compound of wherein Ris 3 claim 1 ,6 claim 1 ,9 claim 1 ,12 claim 1 ,15 claim 1 ,18-hexaazatriacontyl or (2 claim 1 ,3-diamino)tallow and R claim 1 , R claim 1 , Rand Rare hydrogen.4. The compound of wherein Ris 3 claim 1 ,6 claim 1 ,9 claim 1 ,12 claim 1 ,15 claim 1 ,18-hexaazatriacontyl or (2 claim 1 ,3-diamino)tallow and R claim 1 , R claim 1 , Rand Rare methyl.5. The compound of wherein Ris polyethyleneimino and R claim 1 , R claim 1 , Rand Rare hydrogen.6. The compound of wherein Ris polyethyleneimino and R claim 1 , R claim 1 , R claim 1 , and Rare methyl.7. An aqueous herbicidal composition comprising the compound of and an herbicide component comprising one or more herbicides.8. The composition of wherein the herbicide component comprises glyphosate.9. The composition of wherein the herbicide component comprises one or more water-soluble herbicides selected from the group consisting of acifluorfen claim 7 , acrolein claim 7 , amitrole claim 7 , asulam claim 7 , benazolin claim 7 , bentazon claim 7 , bialaphos claim 7 , bromacil claim 7 , bromoxynil claim 7 , chloramben claim 7 , chloroacetic acid claim 7 , clopyralid claim 7 , 2 claim 7 ,4-D claim 7 , 2 claim 7 ,4-DB claim 7 , dalapon claim 7 , dicamba claim 7 , dichlorprop claim 7 , difenzoquat claim 7 , diquat claim 7 , endothall claim 7 , fenac claim 7 , fenoxaprop claim 7 , flamprop claim 7 , flumiclorac claim 7 , fluoroglycofen claim 7 , flupropanate claim 7 , fomesafen claim 7 , fosamine claim 7 , glufosinate claim 7 , imazameth claim 7 , imazamethabenz claim 7 , imazamox claim 7 , imazapic claim 7 , ...

Methods and compositions for producing and selecting transgenic plants

Compositions and methods are provided for the production and selection of transgenic plants and plant parts, for increasing the transformation frequency of a plant or plant part, and for regulating the expression of a transgene, such as a herbicide tolerance polynucleotide. The methods and compositions allow for the delay in the expression of herbicide tolerance polynucleotides until a point in development during which herbicide selection is more efficient. Compositions comprise polynucleotide constructs comprising an excision cassette that separates a transgene, such as a herbicide tolerance polynucleotide, from its promoter and host cells comprising the same. The excision cassette comprises a polynucleotide encoding a site-specific recombinase operably linked to an inducible promoter and expression of the recombinase leads to excision of the excision cassette and expression of the transgene.

METHOD FOR REMOVING GLYPHOSATE FROM A SOLUTION

A method includes removing glyphosate from a solution by contacting the solution with a mesoporous inorganic particle having an average pore size of greater than zero and less than about 50 nm, wherein the mesoporous inorganic particle is functionalized with a positively charged moiety selected from ammonium, amine and combinations thereof. 2. The filtration column of claim 1 , wherein the aqueous solution comprises less than about 2 ppm glyphosate.3. The filtration column of claim 1 , wherein the aqueous solution comprises less than about 500 ppb glyphosate.4. The filtration column of claim 1 , wherein the mesoporous inorganic particle comprises silica.5. The filtration column of claim 1 , wherein the mesoporous inorganic particle is functionalized with a primary amine.6. The filtration column of claim 1 , wherein the mesoporous inorganic particle is substantially spherical.7. The filtration column of claim 1 , wherein the linking group is an alkyl group.8. The filtration column of claim 1 , wherein the packing material further comprises a filler chosen from non-functionalized inorganic particles claim 1 , diatomaceous earth claim 1 , cellulose claim 1 , perlite claim 1 , and combinations thereof.10. The filter construction of claim 9 , wherein the aqueous solution comprises less than about 2 ppm glyphosate.11. The filter construction of claim 9 , wherein the aqueous solution comprises less than about 500 ppb glyphosate.12. The filter construction of claim 9 , wherein the mesoporous inorganic particle comprises silica.13. The filter construction of claim 9 , wherein the mesoporous inorganic particle is functionalized with a primary amine.14. The filter construction of claim 9 , wherein the linking group is an alkyl group. This application is a continuation of U.S. application Ser. No. 14/977,564, filed Dec. 21, 2015, the entire contents of which are hereby incorporated by reference.Glyphosate, a type of organophosphate with the molecular structure shown below, has ...

Phosphonate functional antimicrobial coatings for metal surfaces

The invention relates to quaternary ammonium multi-dentate mono-, bis-, tris- and tetrakis-phosphonate compounds, processes for preparing quaternary ammonium multi-dentate mono-, bis-, tris- and tetrakis-phosphonate compounds, antimicrobial coating compositions comprising quaternary ammonium multi-dentate mono-, bis-, tris- and tetrakis-phosphonate compounds and method of treating a surface with said compositions to provide a durable, antimicrobial-treated surface.

Phosphorus control for waste streams from glyphosate manufacturing processes

This invention relates to processes for the removal of phosphorous from aqueous waste streams comprising phosphorous-containing compounds produced in the manufacture of glyphosate, in order to meet and typically exceed environmental regulations. More particularly, various embodiments of the present invention relate to the removal of phosphorous-containing compounds utilizing biological treatment system(s), oxidizing agent(s), and/or precipitant(s). The processes of the invention are also applicable to the removal of phosphorous compounds from phosphorous-containing waste streams other than those waste streams resulting from the manufacture of glyphosate.

OPTICALLY-ACTIVE 2-AMINO-PHOSPHONOALKANE ACID, OPTICALLY-ACTIVE 2-AMINOPHOSPHONOALKANE ACID SALT, AND HYDRATES OF THESE

A novel compound has pharmacological activities comparable to those of Nahlsgen and is storable excellently stably. The compound can be produced by a method according to the present invention for producing an optically active 2-amino-phosphonoalkanoic acid salt. In the method, a starting material DL-2-amino-phosphonoalkanoic acid represented by Formula (1) or a hydrate thereof is reacted with an optically active basic compound other than an optically active lysine, to give a diastereomeric salt mixture including a first salt (including a hydrate salt) between a D-2-amino-phosphonoalkanoic acid represented by Formula (1-1) and the optically active basic compound, and a second salt (including a hydrate salt) between an L-2-amino-phosphonoalkanoic acid represented by Formula (1-2) and the optically active basic compound. The diastereomeric salt mixture is fractionally crystallized to isolate one of the first and second diastereomeric salts. 2. The method according to claim 1 ,wherein the optically active basic compound is a compound selected from the group consisting of cinchonine, cinchonidine, quinine, quinidine, an optically active arginine, an optically active phenylalaninamide, an optically active ornithine, an optically active tyrosine hydrazide, an optically active 1-phenylpropylamine, an optically active 2-phenylpropylamine, an optically active valinol, an optically active p-hydroxyphenylglycine hydrazide, an optically active p-hydroxyphenylglycine methyl ester, an optically active p-hydroxyphenylglycine ethyl ester, an optically active glucamine, an optically active leucinol, an optically active 1-phenylethylamine, and an optically active 2-amino-1-butanol.3. The method according to claim 1 ,wherein the starting material is the DL-2-amino-phosphonoalkanoic acid represented by Formula (1) in which m is 1, 3, or 5, or a hydrate thereof.4. The method according to claim 1 ,wherein the hydrate of the DL-2-amino-phosphonoalkanoic acid represented by Formula (1) is ...

METHOD FOR THE SYNTHESIS OF N-(PHOSPHONOMETHYL)GLYCINE

The present invention is related to a new method for the synthesis of N-(phosphonomethyl)glycine or one of its derivatives selected from the group consisting of its salts, its phosphonate esters and its phosphonate ester salts, comprising the steps of: a) forming a reaction mixture comprising an acid catalyst, N,N′-bis(carboxymethyl)-2,5-diketopiperazine and a compound comprising one or more P—O—P anhydride moieties, wherein said moieties comprise one P atom at the oxidation state (+111) and the other P atom at the oxidation state (+111) or (+V), to form N,N′-bis(phosphonomethyl)-2,5-diketopiperazine, its dehydrated forms or their phosphonate esters; b) hydrolyzing the reaction mixture to form N-(phosphonomethyl)glycine or one of its derivatives selected from the group consisting of its salts, its phosphonate esters and its phosphonate ester salts. 1. A method for the synthesis of N-(phosphonomethyl)glycine or one of its derivatives selected from the group consisting of its salts , its phosphonate esters and its phosphonate ester salts , comprising the steps of:a) forming a reaction mixture comprising an acid catalyst, N,N′-bis(carboxymethyl)-2,5-diketopiperazine and a compound comprising one or more P—O—P anhydride moieties, wherein said moieties comprise one P atom at the oxidation state (+III) and the other P atom at the oxidation state (+III) or (+V), to form N,N′-bis(phosphonomethyl-2,5-diketopiperazine, its dehydrated forms or their phosphonate esters;b) hydrolyzing the reaction mixture to form N-(phosphonomethyl)glycine or one of its derivatives selected from the group consisting of its salts, its phosphonate esters and its phosphonate ester salts.2. The method according to claim 1 , wherein in step a) claim 1 , the compound comprising a P—O—P anhydride moiety claim 1 , having one P atom at the oxidation state (+III) and the other P atom at the oxidation state (+III) or (+V) claim 1 , is gradually mixed claim 1 , into a mixture comprising N claim 1 ,N′-bis( ...

Method for the synthesis of n-(phosphonomethyl)glycine

A method for the synthesis of N-(phosphonomethyl)glycine or one of its derivatives selected from the group consisting of its salts, its phosphonate esters, or its phosphonate ester salts, which includes the steps of: a) forming, in the presence an acid catalyst, a reaction mixture having 2,5-diketopiperazine, formaldehyde and a compound including one or more P-0-P anhydride moieties, the moieties having one P atom at the oxidation state (+III) and the other P atom at the oxidation state (+III) or (+V), to form N,N′-bisphosphonomethyl-2,5-diketopiperazine, its mono- to tetra phosphonate esters, the dehydrated forms of N,N′-bisphosphonomethyl-2,5-diketopiperazine and the phosphonate esters of its dehydrated forms; and b) hydrolysing the N,N′-bisphosphonomethyl-2,5-diketopiperazine, its dehydrated forms or their phosphonate esters to obtain N-(phosphonomethyl)glycine or one of its derivatives selected from the group consisting of its salts, its phosphonate esters and its phosphonate ester salts.

Method for removing glyphosate from a solution

A method includes removing glyphosate from a solution by contacting the solution with a mesoporous inorganic particle having an average pore size of greater than zero and less than about 50 nm, wherein the mesoporous inorganic particle is functionalized with a positively charged moiety selected from ammonium, amine and combinations thereof.

Method for removing phosphorus compounds from an aqueous medium

The present disclosure provides a method for removing a phosphorus compound from an aqueous medium. In one embodiment, the method includes: providing a rare-earth metal-modified carrier; and contacting the rare-earth metal-modified carrier with an aqueous medium including the phosphorus compound under conditions effective to remove at least a portion of the phosphorus compound from the aqueous medium.

Low Volatile Amine Salts of Anionic Pesticides

The present invention relates to a salt comprising an anionic pesticide and a cationic polyamine of the formula (A) or (B) as described in the description. The invention further relates to an agrochemical composition comprising said salt. It also relates to a method for preparing said salt comprising combining the pesticide in its neutral form or as salt, and the polyamine in its neutral form or as salt. In addition, the invention relates to a method of combating harmful insects and/or phytopathogenic fungi. It also relates to a method of controlling undesired vegetation. Finally, the invention relates to seed comprising said salt. 15-. (canceled)7. (canceled)8. An agrochemical composition comprising at least one salt according to .9. A method for preparing the salt according to comprising combiningthe pesticide in its neutral form or as salt, andthe polyamine in its neutral form or as salt.10. The method according to claim 9 , wherein the pesticide and glyphosate are combined in water.1115-. (canceled)16. A method of combating harmful insects and/or phytopathogenic fungi claim 6 , which comprises contacting plants claim 6 , seed claim 6 , soil or habitat of plants in or on which the harmful insects and/or phytopathogenic fungi are growing or may grow claim 6 , plants claim 6 , seed or soil to be protected from attack or infestation by said harmful insects and/or phytopathogenic fungi with an effective amount of an agrochemical formulation comprising the salt of .17. (canceled)18. A method of controlling undesired vegetation claim 8 , which comprises allowing a herbicidal effective amount of the agrochemical composition according to to act on plants claim 8 , their habitat or on seed of said plants.19. Seed treated with a composition comprising the salt according to .22. The agrochemical composition of claim 8 , comprising10-70 wt % of the salt;30-90 wt % water;optionally a further pesticide; andoptionally up to 10 wt % auxiliaries, wherein the amount of all ...

Three-Compartment Bipolar Membrane Electrodialysis Of Salts Of Amino Acids

This invention relates to an improved electrodialysis method for preparing an amino acid from a salt of the amino acid utilizing a three-compartment bipolar membrane electrodialysis process wherein an aqueous electrolyte comprising an exogenous acid is added to the acid compartment of a three-compartment bipolar membrane apparatus. The exogenous acid is different than the amino acid and typically has a pKa less than the pKa of the amino acid. 1. A process for preparing an amino acid , the process comprising:introducing an aqueous electrolyte comprising a first acid into an acid compartment of a three-compartment electrodialysis bipolar membrane cell comprising an acid compartment, a salt compartment, and a base compartment;introducing a feed salt stream comprising a salt of the amino acid into the salt compartment of the three-compartment bipolar membrane cell; andintroducing an aqueous stream into the base compartment of the three-compartment bipolar membrane cell;wherein the first acid and the amino acid are different.2. The process as set forth in claim 1 , wherein the amino acid has a pKa greater than 2.0 and the first acid introduced into the acid compartment of the three-compartment bipolar membrane cell has a pKa less than the pKa of the amino acid.3. The process as set forth in claim 1 , wherein the pKa of the first acid introduced into the acid compartment of the three-compartment bipolar membrane cell is at least about 0.5 pKa units lower than the pKa of the salt of the amino acid introduced into the salt compartment.4. (canceled)5. The process as set forth in claim 1 , wherein the molar ratio of the salt of the amino acid introduced into the salt compartment of the three-compartment bipolar membrane cell to the first acid of the aqueous electrolyte introduced into the acid compartment of the three-compartment bipolar membrane cell is from about 1:1 to about 1:10.6. The process as set forth in claim 1 , wherein the first acid is selected from the group ...

METHOD FOR THE SYNTHESIS OF AMINOALKYLENEPHOSPHONIC ACID

A method for the synthesis of an aminoalkylenephosphonic acid or its phosphonate esters including the following steps: a) forming, in the presence of an aldehyde or ketone and an acid catalyst, a reaction mixture by mixing a compound having at least one HNRRmoiety or a salt thereof, with a compound having one or more P—O—P anhydride moieties, the moieties having one P atom at the oxidation state (+III) and one P atom at the oxidation state (+III) or (+V), wherein the ratio of moles of aldehyde or ketone to N—H moieties is 1 or more and wherein the ratio of N—H moieties to P—O—P anhydride moieties is 0.3 or more, and b) recovering the resulting aminoalkylenephosphonic acid having compound or its phosphonate esters. 1. A method for the synthesis of an aminoalkylenephosphonic acid or its phosphonate esters , comprising the following steps:{'sup': 1', '2, 'a) forming, in the presence of an aldehyde or ketone and an acid catalyst, a reaction mixture by mixing a compound (a.1.) comprising at least one HNRRmoiety or a salt thereof, with a compound (a.2.) having one or more P—O—P anhydride moieties, said moieties comprising one P atom at the oxidation state (+III) and one P atom at the oxidation state (+III) or (+V), wherein the ratio of moles of aldehyde or ketone to N—H moieties is 1 or more and wherein the ratio of N—H moieties to P—O—P anhydride moieties is 0.3 or more,'}and wherein:{'sup': 1', '2, 'claim-text': [{'sup': 1', '2, 'sub': 1', '6', '1', '6', '1', '6', '1', '6', '1', '6', '1', '6', '1', '4, '(a.1.1) Rand Rare independently selected from the group consisting of hydrogen, C-Calkyl, C-Calkenyl, C-Calkynyl, C-Cacyl, optionally comprising an ethylenically unsaturated double bond, and (meth)acryloyl C-Cmoiety, the C-Cpart of said moieties being normal chained, branched or cyclised and being optionally substituted by one or more moieties selected from the group consisting of C-Chydrocarbon, aryl and aralkyl and optionally comprising one or more heteroatoms selected ...

Biological buffers with wide buffering ranges

Amines and amine derivatives that improve the buffering range, and/or reduce the chelation and other negative interactions of the buffer and the system to be buffered. The reaction of amines or polyamines with various molecules to form polyamines with differing pKa's will extend the buffering range. Derivatives that result in polyamines that have the same pKa yield a greater buffering capacity. Derivatives that result in zwitterionic buffers improve yield by allowing a greater range of stability.

Method for the synthesis of alpha-aminoalkylenephosphonic acid

A method for the synthesis of alpha-aminoalkylenephosphonic acid or its phosphonate esters including the steps of forming a reaction mixture by mixing a P—O—P anhydride moiety including a compound, having one P-atom at the oxidation state (+III) and the other P-atom at the oxidation state (+III) or (+V), an aminoalkanecarboxylic acid and an acid catalyst, wherein the reaction mixture includes an equivalent ratio of alpha-aminoalkylene carboxylic acid to P—O—P anhydride moieties of at least 0.2, and recovering the resulting alpha-aminoalkylene phosphonic acid compound or an ester thereof from the reaction mixture.

Versatile Non-Destructive Surface Modification of Carbonaceous Materials and Process for Grafting Into Polymer Matrices

Disclosed is a non-destructive universal method of functionalization of graphitic carbonaceous materials that enables their alignment, cross-linking, and effective integration into composite materials. 1. A non-destructive method of modifying the surface of carbonaceous materials comprising:activating the surface of the carbonaceous material; andfunctionalizing the activated surface of the carbonaceous materials through treatment with a linker to create a [2+3] dipolar addition.2. The method of claim 1 , wherein the activating the surface of the carbonaceous material is by way of treatment with at least one solvent claim 1 , ultrasound claim 1 , heat claim 1 , microwave radiation claim 1 , or combinations thereof.3. The method of claim 2 , wherein activating the surface of the carbonaceous materials is by way of treatment of the materials with at least one solvent and ultrasound.4. The method of wherein ultrasound is applied at a frequency of between about 20 claim 3 ,000 and about 100 claim 3 ,000 Hz claim 3 , at a power of between about 5 and about 1 claim 3 ,000 watts per gallon claim 3 , and for a duration of at least 10 minutes.5. The method of claim 1 , wherein the linker is a combination of (a) a combination of glycine or N-substituted glycine and (b) an aldehyde (paraformaldehyde).6. The method of claim 5 , wherein the linker further comprises a solvent.7. The method of claim 1 , wherein the functionalization is achieved under heating claim 1 , mechanical pressure claim 1 , ultrasound claim 1 , microwave radiation claim 1 , or combinations thereof.8. The method of claim 1 , further comprising a re-functionalization step.9. The method of claim 1 , further comprising a step of adding a cross-linking reagent.10. The method of claim 9 , wherein the cross-linking reagent is (1 claim 9 ,6-di-(N-maleimido) hexane).11. The method of claim 9 , wherein the cross-linking reagent is a diamine or polyamine claim 9 , diol claim 9 , or polyol.12. The method of claim 9 , ...

Trimethylolpropane core, phosphonic acid terminated dendrimer and its preparation method

A trimethylolpropane core, phosphonic acid terminated dendrimer and its preparation method are provided, And a preparation method thereof comprises steps of processing Michael addition reaction on trimethylolpropane triacrylate (CHCHC(CHOCOCH═CH)) and alkylidene diamine (NHCH(CH)NH), wherein n is an integer from 1 to 5, so as to obtain trimethylolpropane core, amino group terminated dendrimer, and modifying the amino group by methylene phosphonic acid to obtain the trimethylolpropane core, phosphonic acid terminated dendrimer having a chemical formula of CHCHC[CHOCOCHCHN(CHPOH)CH(CH)N(CHPOH)], wherein n is an integer from 1 to 5. The trimethylolpropane core, phosphonic acid terminated dendrimer has high calcium tolerance, and excellent inhibiting efficiency of calcium carbonate, calcium sulfate and barium sulfate, which is applied in inhibiting the formation and deposition in industrial water systems of circulating cooling water, oilfield flooding and reverse osmosis, and particularly suitable for water treatment with high calcium tolerance. 3. The preparation method claim 2 , as recited in claim 2 , wherein in the Michael reaction of the step (1) claim 2 , a molar ratio of the trimethylolpropane triacrylate to the alkylenediamine is 1: (4˜6).4. The preparation method claim 2 , as recited in claim 2 , wherein in the methane phosphorylation of the step (2) claim 2 , a molar ratio of the intermediate trimethylolpropane core claim 2 , amino terminated dendrimer claim 2 , the phosphorous acid claim 2 , the formaldehyde and the hydrochloric acid is 1:(9.0˜9.2):(11.0˜12.0):(11.0˜12.0).5. A method of inhibiting the deposition of scale in water treatment including calcium carbonate claim 1 , calcium sulfate and barium sulfate claim 1 , comprising introducing into the water treatment an effective scale inhibiting amount of the trimethylolpropane core claim 1 , phosphonic acid terminated dendrimer having the formula as recited in claim 1 , wherein the trimethylolpropane core ...

Biological Buffers with Wide Buffering Ranges

Amines and amine derivatives that improve the buffering range, and/or reduce the chelation and other negative interactions of the buffer and the system to be buffered. The reaction of amines or polyamines with various molecules to form polyamines with differing pKa's will extend the buffering range, derivatives that result in polyamines that have the same pKa yields a greater buffering capacity. Derivatives that result in zwitterionic buffers improve yield by allowing a greater range of stability.

SINGLE PHASE LIQUIDS OF ALKANOLAMINE SALTS OF DICAMBA

The invention is a herbicidal composition containing an alkanolamine salt of an dicamba capable of remaining as a single phase liquid over a period of at least 1 week and containing low amounts of water and high loadings of the salt. Such herbicidal compositions are capable of remaining liquid in the absence of high amounts of water, thereby enhancing their capacity to remain liquid over an extended period of time when exposed to environmental conditions to improve their effectiveness to transport the active salt through a leafy substrate and can reduce transportation costs by increasing the salt loading without compromising the stability of the composition. 1. A herbicidal composition comprising water and an alkanolamine salt , said alkanolamine salt comprising the reaction product of an alkanolamine compound with dicamba , wherein said alkanolamine salt is capable of remaining a single phase liquid for at least 1 week , said capability determined by subjecting said alkanolamine salt to the following test conditions: 2 ml of a sample containing said alkanolamine salt and less than 5 wt. % water , based on the weight of the sample , and no non-aqueous solvents is placed onto a glass surface and exposed to the atmosphere at a temperature within a range of 20° C. to 25° C. and at approximately 1 atmosphere.2. The herbicidal composition of claim 1 , wherein sample undergoing said test does not contain solids dispersed throughout the liquid.3. The herbicidal composition of claim 1 , wherein the sample undergoing said test contains no added solvent other than water.4. The composition of claim 3 , wherein the sample undergoing the test conditions contains water in an amount of no more than 3 wt. % based on the weight of the sample claim 3 , and no other added solvents.5. The herbicidal composition of claim 4 , wherein the herbicidal composition contains water present in an amount of not more than 10 wt. % based on the weight of the herbicidal composition.6. The herbicidal ...

Biological Buffers with Wide Buffering Ranges

Amines and amine derivatives that improve the buffering range, and/or reduce the chelation and other negative interactions of the buffer and the system to be buffered. The reaction of amines or polyamines with various molecules to form polyamines with differing pKa's will extend the buffering range, derivatives that result in polyamines that have the same pKa yields a greater buffering capacity. Derivatives that result in zwitterionic buffers improve yield by allowing a greater range of stability. 2. The biological buffer and its salts of wherein A=D=—CH3 and m=1.3. The biological buffer and its salts of wherein A=D=—CH2OH and m=1.4. The biological buffer and its salts of wherein A=D-CH2O(CH2CH2CH2N)H and n=m=1.5. The biological buffer and its salts of wherein A=—CH2CH3 claim 1 , D=—CH2O(CH2CH2CH2N)H and n=m=1.6. The biological buffer and its salts of wherein A=—CH3 claim 1 , D=—CH2O(CH2CH2CH2N)H and n=m=1.7. The biological buffer and its salts of wherein A is —CH3 and D is —CH2CH3.9. The quaternary ammonium compound and its salts of wherein A=D=—CH3 claim 8 , E=—CH2OH claim 8 , R=R′=—CH3 and G=—H.10. The quaternary ammonium compound and its salts of wherein A=D=E=—CH2OH claim 8 , R=R′=—CH3 and G=—H.11. The quaternary ammonium compound and its salts of wherein A=D=—CH3 claim 8 , E=—CH2OH claim 8 , R=R′=—CH3 and G=—CH2CH3.12. The quaternary ammonium compound and its salts of wherein A=D=E=—CH2OH claim 8 , R=R′=—CH3 and G=—CH2CH3.14. The surfactant of wherein A is —H and D is —CH3.15. The surfactant of wherein A is —CH3 and D is chosen from —CH3 claim 13 , —CH2CH3 claim 13 , —CH2CH2CH3 claim 13 , —CH2OH.16. The surfactant of wherein A is —CH3 and D is chosen from —CH2CH2CH3 claim 13 , —CH2OH.17. The surfactant of wherein A is —CH3 and D is —CH2OH. This is a continuation of application Ser. No. 15/255,654 filed Sep. 2, 2016 and other previous parent applications claimed in the Application Data Sheet. application Ser. No. 15/255,654 is hereby incorporated by reference ...

Method for the synthesis of alpha-aminoalkylenephosphonic acid

The present invention is related to a new method for the synthesis of alpha-aminoalkylenephosphonic acid or its phosphonate esters comprising the steps of forming a reaction mixture by mixing a P—O—P anhydride moiety comprising compound, having one P-atom at the oxidation state (+III) and the other P-atom at the oxidation state (+III) or (+V), an aminoalkanecarboxylic acid and an acid catalyst, wherein said reaction mixture comprises an equivalent ratio of alpha-aminoalkylene carboxylic acid to P—O—P anhydride moieties of at least 0.2, and recovering the resulting alpha-aminoalkylene phosphonic acid compound or an ester thereof from the reaction mixture.

CONTROL OF N-(PHOSPHONOMETHYL)IMINODIACETIC ACID CONVERSION IN MANUFACTURE OF GLYPHOSATE

This invention relates to the preparation of N-(phosphonomethyl)glycine (“glyphosate”) from N-(phosphonomethyl)iminodiacetic acid (“PMIDA”), and more particularly to methods for control of the conversion of PMIDA, for the identification of reaction end points relating to PMIDA conversion and the preparation of glyphosate products having controlled PMIDA content. 1123-: (canceled)124. A method for monitoring or detecting the conversion of N-(phosphonomethyl)iminodiacetic acid to N (phosphonomethyl)glycine or another intermediate for N (phosphonomethyl)glycine in the course of the catalytic oxidation of N-(phosphonomethyl)iminodiacetic acid in an aqueous medium , the method comprising:introducing an aqueous medium containing N (phosphonomethyl)iminodiacetic acid into an oxidation reaction zone;contacting N-(phosphonomethyl)iminodiacetic acid with an oxidizing agent in said aqueous medium within said oxidation reaction zone in the presence of a catalyst for the oxidation, thereby effecting oxidation of N-(phosphonomethyl)iminodiacetic acid and producing N-(phosphonomethyl)glycine or said another intermediate;continually or repetitively measuring the exothermic heat generated in said reaction zone;monitoring the instantaneous rate of exothermic heat generated in the conversion of N-(phosphonomethyl)iminodiacetic acid to N (phosphonomethyl)glycine or said another intermediate; andestimating the residual concentration of N (phosphonomethyl)iminodiacetic acid in said aqueous medium within said reaction zone, said estimating comprising comparing said rate of exothermic heat generation with the mass of aqueous medium containing N-(phosphonomethyl)iminodiacetic acid that is charged to the reaction zone or a function thereof.125134-: (canceled)135. A method for monitoring or detecting the conversion of N-(phosphonomethyl)iminodiacetic acid to N (phosphonomethyl)glycine or another intermediate for N (phosphonomethyl)glycine in the course of the catalytic oxidation of N-( ...

Herbizide zubereitung

Oxidation with coated catalyst

Processes are described wherein formaldehyde or formic acid and similar materials are oxidized to produce carbon dioxide and water by contact with oxygen in the presence of a noble metal catalyst on a carbon support that is protected from poisonous amines by a polymer coating.

Oxidation catalyst and process for its preparation and process for oxidation using it

An oxidation catalyst is prepared by pyrolyzing a source of iron and a source of nitrogen on a carbon support. Preferably, a noble metal is deposited over the modified support which comprises iron and nitrogen bound to the carbon support. The catalyst is effective for oxidation reactions such as the oxidative cleavage of tertiary amines to produce secondary amines, especially the oxidation of N-(phosphonomethyl)iminodiacetic acid to N-(phosphonomethyl)-glycine.

Thinners for aqueous suspensions of mineral particles and hydraulic binder pastes

Use of compounds comprising at least one phosphonic amino-alkylene grouping and at least one polyoxyalkylated chain and the salts thereof, as thinning agents for aqueous suspensions of mineral particles and hydraulic binder pastes. The invention also concerns novel compounds including at least one phosphonic amino-alkylene grouping and at least one polyoxyalkylated chain as well as the salts thereof.

CATALYSTS CONTAINING TRANSITIONAL METALS, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS OXIDATION AND DEHYDROGENATION CATALYSTS

Catálisis heterogénea y más particularmente catalizadores que incluyen soportes de carbón a partir de los cuales se forman preparados que contiene un metal de transmisión combinado con nitrógeno y/o carbono. La presente se relaciona además con los campos de las reacciones de oxidación y deshidrogenación catalíticas, que incluyen la preparación de aminas secundarias mediante la oxidación catalítica de aminas terciarias y la preparación de ácidos carboxílicos mediante la deshidrogenación de alcoholes. Reivindicación 154: Un proceso para la oxidación de un sustrato orgánico, caracterizado porque dicho proceso comprende poner en contacto dicho sustrato con un agente oxidante en presencia de un catalizador de oxidación, donde dicho catalizador de oxidación comprende un soporte de carbón sobre el cual se ha formado una composición de un metal de transición que comprende un metal de transición, carbono y nitrógeno; caracterizándose dicho catalizador por su eficacia para catalizar la oxidación de formaldehído, de modo tal que cuando una solución acuosa representativa que contiene aproximadamente 0,8 % en peso de formaldehído y un pH de aproximadamente 1,5 se pone en contacto con un agente oxidante en presencia de dicho catalizador a una temperatura de aproximadamente 100° C, al menos aproximadamente el 5 % de dicho formaldehído se transforma en ácido fórmico, dióxido de carbono y/o agua; o de modo tal que cuando una solución acuosa representativa que contiene aproximadamente 0,8 % en peso de formaldehído y aproximadamente 6 % en peso de ácido N-(fosfonometil)iminodiacético y que tiene un pH de aproximadamente 1,5 se pone en contacto con un agente oxidante en presencia de dicho catalizador a una temperatura de aproximadamente 100° C, al menos aproximadamente el 50 % del formaldehído se transforma en ácido fórmico, dióxido de carbono y/o agua. Heterogeneous catalysis and more particularly catalysts that include carbon supports from which preparations are formed containing a ...

PROCESS AND CATALYST TO DEHYDROGEN PRIMARY ALCOHOLS TO MAKE SALTS OF CARBOXYL ACIDS

Proceso para hacer una sal de ácido carboxílico. El proceso comprende poner en contacto un catalizador con una mezcla alcalina que comprende un alcohol primario. En una realizacion, por ejemplo, el catalizador comprende un soporte metálico (preferiblemente un soporte de esponja metal) que en la superficie del mismo tiene una fase activa que contiene cobre. El soporte es resistente a la deformacion bajo las condiciones de la reaccion de deshidrogenacion. En otra realizacion, el catalizador comprende por lo menos aproximadamente 15% en peso de un metal diferente del cobre y por lo menos aproximadamente 10% en peso de cobre. En esta realizacion es particularmente preferible que el catalizador esté en forma de esponja de metal. La presente también está dirigida a un catalizador que contiene cobre el cual puede, por ejemplo, usarse en el proceso anterior. Además, está dirigida a un proceso para preparar tales catalizadores. Process to make a carboxylic acid salt. The process comprises contacting a catalyst with an alkaline mixture comprising a primary alcohol. In one embodiment, for example, the catalyst comprises a metal support (preferably a metal sponge support) which on the surface thereof has an active phase containing copper. The support is resistant to deformation under the conditions of the dehydrogenation reaction. In another embodiment, the catalyst comprises at least about 15% by weight of a metal other than copper and at least about 10% by weight of copper. In this embodiment it is particularly preferable that the catalyst is in the form of a metal sponge. The present is also directed to a catalyst containing copper which can, for example, be used in the above process. In addition, it is directed to a process to prepare such catalysts.

USE OF METAL IN SUPPORTED CATALYSTS, CONTAINING METAL

Mejoras en el uso de metal en catalizadores soportados, que contienen metal. Por ejemplo, la presente se refiere a métodos para dirigir y/o controlar la deposición de metal sobre las superficies de sustratos porosos. La presente también se refiere a métodos para preparar catalizadores donde se deposita un primer metal sobre un soporte (por ejemplo, un soporte de carbono poroso) para proveer una o más regiones de un primer metal en la superficie del soporte, y se deposita un segundo metal en la superficie de las una o más regiones del primer metal. En general, el carácter electropositivo del primer metal (por ejemplo, cobre o hierro) es mayor que el carácter electropositivo del segundo metal (por ejemplo, un metal noble tal como platino) y el segundo metal se deposita en la superficie de las una o más regiones del primer metal por desplazamiento del primer metal. La presente también se refiere a sustratos tratados, estructuras precursoras del catalizador y catalizadores preparados por dichos métodos. La presente también se refiere al uso de catalizadores preparados según se detalla aquí en reacciones de oxidación catalítica, como por ejemplo oxidación de un sustrato que se selecciona entre el grupo que consiste en acido N-(fosfonometil)iminodiacético o una sal del mismo, formaldehído, y/o ácido fórmico. Improvements in the use of metal in supported catalysts, which contain metal. For example, this refers to methods for directing and / or controlling the deposition of metal on the surfaces of porous substrates. This also refers to methods for preparing catalysts where a first metal is deposited on a support (eg, a porous carbon support) to provide one or more regions of a first metal on the surface of the support, and a second is deposited metal on the surface of the one or more regions of the first metal. In general, the electropositive character of the first metal (for example, copper or iron) is greater than the electropositive character of the second metal (for ...

Process for purifying aminomethylenephosphonic acids.

High purity ethylenediaminetetra (methylenephosphonic acid) and

METHOD FOR PREPARING A DRY PHYTOACTIVE COMPOSITION OF AMMONIUM N-PHOSPHONE-METHYLGLYCIN

Método para preparar una composición fitoactiva seca de N-fosfono- metilglicina de amonio capaz de recibir una carga elevada de uno o doscoadyuvantes porque comprende el paso de hacer reaccionar hidróxido de amonio acuoso conN-fosfo nometilglicina en un sistema de reactor convencionalde modo tal que el contenido de humedad de la masa de reacción disminuya constantemente durante la reacción. Method for preparing a dry phytoactive composition of ammonium N-phosphono-methylglycine capable of receiving a high charge of one or two adjuvants because it comprises the step of reacting aqueous ammonium hydroxide with N-phosphono-methylglycine in a conventional reactor system in such a way that the Moisture content of the reaction mass constantly decreases during the reaction.

Process.

Un proceso por medio del cual se fabrica N-fosfonometilglicina (glifosato) o sus sales mediante:1) la formación de N-fosfonometilglicinonitrilo mediante la reacción de ácido aminofosfónico, un cianuro de metal álcali y formaldehido en una soluciónacuosa a un pH en el margen de 10 a 13 (y preferiblemente de 11 a 11,5) mientras que se le agrega ácido mineral a una tasa suficiente como paramantener el pH dentro del margen deseado, y a continuación 2) la hidrolizacióndel N-fosfonometilglicinonitrilo producto de la Etapa (1)para formar una sal de N-fosfonometilglicina y opcionalmente 3) la neutralización de la sal de N-fosfonometilglicina para formarN-fosfonometilglicina. A process by which N-phosphonomethylglycine (glyphosate) or its salts are manufactured by: 1) the formation of N-phosphonomethylglycinonitrile by the reaction of aminophosphonic acid, a metal alkali cyanide, and formaldehyde in an aqueous solution at a pH in the range 10 to 13 (and preferably 11 to 11.5) while adding mineral acid at a rate sufficient to keep the pH within the desired range, and then 2) hydrolyzing the N-phosphonomethylglycinonitrile product of Step (1) to form an N-phosphonomethylglycine salt and optionally 3) neutralization of the N-phosphonomethylglycine salt to form N-phosphonomethylglycine.

PROCEDURE TO PREPARE N-PHOSPHONE METHYLGLYCIN (GLYPHOSATE) OR A SALT OF THE SAME

Se revela un procedimiento para preparar N-fosfonometilglicina o una sal de la misma por puesta en contacto del ácido fosfonometiliminodiacético o una sal del mismo con por lo menos un oxidante que contiene oxígeno en presencia de un catalizador heterogéneo, en donde el catalizador heterogéneo contiene por lo menos un silicato. La N-fosfonometilglicina está representada por la formula (1) y es util como herbicida de post-emergencia de amplio espectro. A process for preparing N-phosphonomethylglycine or a salt thereof is disclosed by contacting phosphonomethyliminodiacetic acid or a salt thereof with at least one oxygen containing oxidant in the presence of a heterogeneous catalyst, wherein the heterogeneous catalyst contains At least one silicate. N-phosphonomethylglycine is represented by formula (1) and is useful as a broad-spectrum post-emergence herbicide.

Facile synthesisof phosphonomethylglycine from phosphonomethyliminodiacetic acid.

A process for the preparation of phosphonomethylglycine in\s nearly quantitative yields which eliminates the use of a noble metal co-catalyst and its concomitant problems. The oxygen-containing gas is replaced with the much more chemically active hydrogen peroxide, which in combination with activated carbon, oxidizes the pmida to png in very high yeild. The amount of oxidant allowed to react with pmida is a function of the concentration of oxygen in the gaseous reaction products, and is controlled by monitoring that concentration. In another embodiment, the oxidizing agent is an oxygen-containing gas. In either case, the concentration of oxygen in the gaseous reaction product is monitored to determine the end point of the reaction.

PROCEDURE FOR THE PREPARATION OF N- (PHOSPHONOMETIL) GLYCINE

Se describe un procedimiento para la preparacion de la N-(fosfonometil) glicina, mediante: (a) oxidacion del ácido N-(fosfonometil) iminodiacético (PMIDA)mediante peroxidos u oxígeno en un medio acuoso en la presencia de un catalizador heterogéneo, e n un intervalo de temperaturas de 50 a 150*C; (b) subsiguienteseparacion del catalizador solido a partir de la suspension reactiva acuosa de la reaccion de la etapa (a); (c) concentracion de la solucion reactivatransparente de la etapa (b), en especi al mediante evaporacion; y (d) separacion de la N-(fosfonometil) glicina de la solucion reactiva concentrada de la etapa(c), en especial mediante filtracion, en el cual la solucion reactiva acuosa de la etapa (b) (lejía madre), junto con reducidas ca ntidades de N-(fosfonometil)glicina y productos secundarios es reintroducida en la etapa (b) (separacion del catalizador) y/o etapa (c) (concentracion). De esta manera se logra unmanifiesto aumento del rendimiento, manteniéndose constante la pureza d el producto, además de una marcada reduccion de la cantidad de lejía madre. A process for the preparation of N- (phosphonomethyl) glycine is described by: (a) oxidation of N- (phosphonomethyl) iminodiacetic acid (PMIDA) by peroxides or oxygen in an aqueous medium in the presence of a heterogeneous catalyst, in a temperature range of 50 to 150 * C; (b) subsequent separation of the solid catalyst from the aqueous reactive suspension of the reaction of step (a); (c) concentration of the reactivated transparent solution of step (b), specifically by evaporation; and (d) separation of the N- (phosphonomethyl) glycine from the concentrated reactive solution of step (c), especially by filtration, in which the aqueous reactive solution of step (b) (mother liquor), together with Reduced amounts of N- (phosphonomethyl) glycine and by-products are reintroduced in step (b) (catalyst separation) and / or step (c) (concentration). In this way a significant increase in yield is achieved, keeping ...

PROCEDURE TO PREPARE PHOSPHONOMETILGLYCIN.

La presente invencion se refiere a un procedimiento para preparar fosfonometilglicina, donde se pone en contacto en un lugar de reaccion N-oxido de ácidoN-fosfonometiliminodiacético con una cantidad de eficacia catalítica de por lo menos uncatalizad or, que es seleccionado entre un halogenuro de tionilo,ditionita de amonio o una ditionita de metal alcalino, un dialquilsulfito, dicloruro de azufre, dioxido de azufre y ácido sulfuroso, adicionando en el lugar dereaccion el N-oxido delácido N-fosf onometiliminodiacético de forma tal que siempre se transforme por lo menos el 50% del N-oxido adicionado en el lugar dereaccion. The present invention relates to a process for preparing phosphonomethylglycine, where N-phosphonomethyliminodiacetic acid N-oxide reaction is contacted with an amount of catalytic efficiency of at least one catalyst, which is selected from a thionyl halide , ammonium dithionite or an alkali metal dithionite, a dialkylsulfite, sulfur dichloride, sulfur dioxide and sulfurous acid, adding on the reaction site the N-phosphonimine diacetic N-oxide in such a way that it always transforms at least the 50% of the added N-oxide at the reaction site.

PROCEDURE FOR OBTAINING N-PHOSPHONOMETILGLYCIN.

Procedimiento para la obtención de N-fosfonometilglicina de la fórmula (1) a partir de una mezcla acuosa que contiene disueltos en la misma N-fosfonometilglicina, halogenuros de amonio, así como también halogenuros de metales alcalinos o alcalinotérreos y eventualmente impurezas orgánicas, en donde a) se ajusta el pH de la mezcla a un valor en el rango de 2 a 8; b) se realiza una separación de la mezcla en una membrana de nanofiltración selectiva, obteniéndose un retentato más rico en N-fosfonometilglicina y más pobre en halogenuros y un permeato más rico en halogenuros y más pobre en N-fosfonometilglicina; y c) se obtiene N-fosfonometilglicina a partir de retentato. El procedimiento descripto permite la obtención de la N-fosfonometilglicina con separación simultánea de las sales de halogenuros. La N-fosfonometilglicina, también conocida como glifosato, es un herbicida total ampliamente utilizado en el agro. Process for obtaining N-phosphonomethylglycine of the formula (1) from an aqueous mixture containing dissolved therein N-phosphonomethylglycine, ammonium halides, as well as alkali metal or alkaline earth metal halides and possibly organic impurities, where a) the pH of the mixture is adjusted to a value in the range of 2 to 8; b) a separation of the mixture is carried out in a selective nanofiltration membrane, obtaining a retentate richer in N-phosphonomethylglycine and poorer in halides and a permeate richer in halides and poorer in N-phosphonomethylglycine; and c) N-phosphonomethylglycine is obtained from retentate. The described procedure allows to obtain the N-phosphonomethylglycine with simultaneous separation of the halide salts. N-phosphonomethylglycine, also known as glyphosate, is a total herbicide widely used in agriculture.

PROCEDURE FOR THE PREPARATION OF N-PHOSPHONOMETILGLYCIN

La N-fosfonometilglicina (Glifosato) es un herbicida total utilizado ampliamente. Se conocen numerosos procedimientos para la preparacion defosfonometilglicina. Sin embargo, aun se requiere proveer un procedimiento sencillo y economico para la prepar acion de fosfonometilglicina, por medio del cualse pueda obtener la fosfonometilglicina además con gran pureza. Sorprendentemente, se hallo que este objeto se alcanza cuando se hace reaccionar un derivado dehexahidrotriazina con un triacilfosfito y a continuacion se hidroliza el producto obtenido a fosfonometilglicina. Un procedimiento para la preparacion de N-fosfonometilglicina, en donde se hace reaccionar: a) un derivado de hexahidrotriazina de la formula 2 en donde X representa CN, COOZ, CO NR1R2 o CH2OY, Yrepresenta H o un resto que puede ser intercambiado fácilmente por H; Z representa H, un metal alcalino, un metal alcalinotérreo, alquilo C1-18 o arilo,opcionalmente sustituido por alquilo C1-4, NO2 o alquilo OC1-4; R1 y R2, que puede n ser iguales o diferentes, representan H o alquilo C1-4, con untriacilfosfito de la formula P(OCOR3)3 en donde los restos R3, que pueden ser iguales o diferentes representan alquilo C1-18 o arilo, que está opcionalmentesusutituido por alquilo C1-4, NO2 o alquilo OC1-4, y b) se hidroliza el producto obtenido y, en caso de que X represente CH2OY, se oxida. Un procedimiento deacuerdo con el descripto en donde por transformacion del derivado de hexahidrotriazina de la formula 2 con el triacilfosfit o de la formula 3 se obtiene uncompuesto de la formula 1: en donde R3 y X tienen los significados indicados anteriormente. Compuestos fosfono de la formula 1 y compuesto intermedio que seobtiene por transformacion de un derivado de hexahidrotriazina de la formula 2 con triacilfosfito de la formula 3. N-phosphonomethylglycine (glyphosate) is a total herbicide widely used. Numerous processes are known for the preparation of phosphonomethylglycine. However, it is still necessary to provide a ...

PROCESS TO PREPARE A DIALQUILESTER OF N-PHOSPHONOMETIL-GLICINA

Dicho dialquiléster es representado por la formula (1), donde R es un grupo alquilo C1-6, y comprende poner en contacto una sal de glicinato,formaldehido y un fosfito en un medio acuoso a un pH superior a 9, teniendo dicho fosfito la formula (RO)3P donde R1 es un grupo alquilo o arilo, dondela relacion molar de equivalentes de glicina respecto al fosfito es de 1,5:1 a 5:1. En una realizacion, se usa triarilfosfito, alcohol y etoxidode sodio para producir el trialquilfosfito, utilizado sin purificacion. En otra realizacion, se extrae un dialquiléster de la mezcla de reaccionantes de efectuar una hidrolisis. El glifosato es un producto fitotoxico muy eficaz y comercialmente muy importante, util para controlar una granvariedad de malezas y cultivos. Said dialkyl ester is represented by the formula (1), wherein R is a C1-6 alkyl group, and comprises contacting a glycinate, formaldehyde salt and a phosphite in an aqueous medium at a pH greater than 9, said phosphite having the formula (RO) 3P where R1 is an alkyl or aryl group, where the molar ratio of glycine equivalents to phosphite is 1.5: 1 to 5: 1. In one embodiment, triaryl phosphite, alcohol and sodium ethoxide are used to produce the trialkyl phosphite, used without purification. In another embodiment, a dialkyl ester is extracted from the mixture of reactants to effect hydrolysis. Glyphosate is a very effective and commercially very important phytotoxic product, useful for controlling a great deal of weeds and crops.

PROCEDURE FOR THE PREPARATION OF N-PHOSPHONOMETILGLYCIN

Procedimiento para la preparación de N-fosfonometilglicina de la fórmula (1) en la que a) se hace reaccionar un derivado de hexadihidrotriazina de la fórmula (2) en donde X representa CN, COOZ, CONR1R2 o CH2OY, Y representa H o un resto que puede ser intercambiado fácilmente por H; Z representa H, un metal alcalino, un metal alcalinotérreo, alquilo C1-18 o arilo opcionalmente sustituido por alquilo C1-4, NO2 o OC1-C4-alquilo; R1 y R2 que pueden ser iguales o diferentes, representan H o alquilo C1-4 con un triacilfosfito de la fórmula (3): P(OCOR3)3 en donde los restos R3, que pueden ser iguales o diferentes, representan alquilo C1-18 o arilo, que está opcionalmente sustituido por alquilo C1-4, NO2 o OC1-4-alquilo en un solvente orgánico; b) se extrae la mezcla de reacción obtenida con agua o una solución acuosa de un ácido o una solución acuosa de una base; c) se separan las fases; y d) se hidroliza el producto obtenido en la fase acuosa. Por este procedimiento se evita la descomposición del solvente orgánico durante la saponificación. La fosfonometilglicina o glifosato es un herbicida total que es utilizado ampliamente. Process for the preparation of N-phosphonomethylglycine of the formula (1) in which a) a hexadihydrotriazine derivative of the formula (2) is reacted wherein X represents CN, COOZ, CONR1R2 or CH2OY, Y represents H or a residue which can be easily exchanged for H; Z represents H, an alkali metal, an alkaline earth metal, C1-18 alkyl or aryl optionally substituted by C1-4 alkyl, NO2 or OC1-C4-alkyl; R1 and R2 which may be the same or different, represent H or C1-4 alkyl with a triacylphosphite of the formula (3): P (OCOR3) 3 wherein the R3 moieties, which may be the same or different, represent C1-18 alkyl or aryl, which is optionally substituted by C1-4 alkyl, NO2 or OC1-4-alkyl in an organic solvent; b) the reaction mixture obtained is extracted with water or an aqueous solution of an acid or an aqueous solution of a base; c) the phases are ...

Process

N-SULFONOMETHYLGLYCINATE PROCESS FOR THE PREPARATION, USE IN THE PREPARATION OF GLYPHOSATE-LIKE HERBICIDES

Process for preparing sodium salt of n-phosphonomethylglycine

The sesquisodium salt of N-phosphonomethylglycine is a unique crystalline compound which has utility as a post-emergent herbicide and is also useful to increase the sucrose content of sugarcane.

Способ получения n-фосфонометилглицина и промежуточный продукт для его получения

Изобретение относится к усовершенствованному способу получения N-фосфонометилглицина, который заключается в том, что производное гексагидротриазина ф-лы (II) где Х представляет CN, COOZ, СН 2 OY и др., Z и Y представляют водород и др., подвергают взаимодействию с триацилфосфитом ф-лы Р(OCOR 3 ) 3 (III), где R 3 обозначает C 1 -C 18 алкил или арил, который может иметь заместители, полученный продукт гидролизуют и, если Х представляет собой СН 2 OY, окисляют. Описываемый способ является простым в осуществлении, экономичен и обеспечивает высокую степень чистоты целевого продукта. 2 н. и 17 з.п. ф-лы. ÐÎÑÑÈÉÑÊÀß ÔÅÄÅÐÀÖÈß (19) RU (51) ÌÏÊ 7 (11) 2 260 010 (13) C2 C 07 F 9/38, 9/40 ÔÅÄÅÐÀËÜÍÀß ÑËÓÆÁÀ ÏÎ ÈÍÒÅËËÅÊÒÓÀËÜÍÎÉ ÑÎÁÑÒÂÅÍÍÎÑÒÈ, ÏÀÒÅÍÒÀÌ È ÒÎÂÀÐÍÛÌ ÇÍÀÊÀÌ (12) ÎÏÈÑÀÍÈÅ ÈÇÎÁÐÅÒÅÍÈß Ê ÏÀÒÅÍÒÓ (21), (22) Çà âêà: 2002119555/04, 22.12.2000 (72) Àâòîð(û): ÂÓËÜÔÔ Êðèñòèàí (DE), ÎÐÑÒÅÍ Øòåôàí (DE), ÎÔÒÐÈÍà Àëüôðåä (DE) (24) Äàòà íà÷àëà äåéñòâè ïàòåíòà: 22.12.2000 (30) Ïðèîðèòåò: 23.12.1999 DE 19962601.4 (45) Îïóáëèêîâàíî: 10.09.2005 Áþë. ¹ 25 2 2 6 0 0 1 0 (56) Ñïèñîê äîêóìåíòîâ, öèòèðîâàííûõ â îò÷åòå î ïîèñêå: SU 662015 À, 05.05.1979. ÅÐ 0104775 À1, 04.04.1984. ÅÐ 0149294 A1, 24.07.1985. ÅÐ 0097522 A2, 04.01.1984. (85) Äàòà ïåðåâîäà çà âêè PCT íà íàöèîíàëüíóþ ôàçó: 23.07.2002 (86) Çà âêà PCT: EP 00/13162 (22.12.2000) 2 2 6 0 0 1 0 R U Àäðåñ äë ïåðåïèñêè: 101000, Ìîñêâà, Ì.Çëàòîóñòèíñêèé ïåð., ä.10, êâ.15, "ÅÂÐÎÌÀÐÊÏÀÒ", Ì.Â.Êîëåñíèêîâîé C 2 C 2 (87) Ïóáëèêàöè PCT: WO 01/47938 (05.07.2001) (54) ÑÏÎÑÎÁ ÏÎËÓ×ÅÍÈß N-ÔÎÑÔÎÍÎÌÅÒÈËÃËÈÖÈÍÀ È ÏÐÎÌÅÆÓÒÎ×ÍÛÉ ÏÐÎÄÓÊÒ ÄËß ÅÃÎ ÏÎËÓ×ÅÍÈß (57) Ðåôåðàò: Èçîáðåòåíèå îòíîñèòñ ê óñîâåðøåíñòâîâàííîìó ñïîñîáó ïîëó÷åíè Nôîñôîíîìåòèëãëèöèíà, êîòîðûé çàêëþ÷àåòñ â òîì, ÷òî ïðîèçâîäíîå ãåêñàãèäðîòðèàçèíà ô-ëû (II) ãäå Õ ïðåäñòàâë åò CN, COOZ, ÑÍ2OY è äð., Z è Y ïðåäñòàâë þò âîäîðîä è äð., ïîäâåðãàþò âçàèìîäåéñòâèþ ñ òðèàöèëôîñôèòîì ô-ëû Ð(OCOR 3)3 (III), ãäå R 3 îáîçíà÷àåò C1-C18 àëêèë èëè àðèë, êîòîðûé ìîæåò èìåòü çàìåñòèòåëè, ïîëó÷åííûé ïðîäóêò ...

グリホサートまたはその塩の製造法

(57)【要約】 不均一触媒の存在下、ホスホノメチルイミノ二酢酸またはその塩を少なくとも１種の酸素含有酸化剤と接触させてＮ−ホスホノメチルグリシンまたはその塩を製造する方法において、不均一触媒が少なくとも１種のケイ酸塩を含んでいる。

Process for producing n-phosphono methyl gylcine

Oxidation of (HO)2P (O) CH2N (CH2CO2H)2 with oxygen-contg. gas, the pressure of which is 1-7kg/cm2, on the activated carbon at 90-150≰C gave the herbicide (HO)2P (O) CH2NHCH2CO2H. The reaction was related to the type of activated carbon, its PH, and its effective surface area as well as reaction time and temp. and was faster with activated carbon of pH/6.0 than pH<4.0.

Method of preparing alpha-aminophosphonic acids

The invention relates to compounds containing phosphorus- carbon-nitrogen bond of the general formula I <IMAGE> wherein R1 and R2 are the same or different and stand for hydrogen or an organic radical, R3 and R4 are the same or different and stand for hydrogen, hydroxy or an organic radical. The compounds are prepared by reacting a phosphorus halide with ammonia, water soluble ammonium salts, primary or secondary amine in the presence of water and further with aldehyde or ketone. The product is recovered by reducing the reaction volume or by adding a water miscible organic solvent to the reaction mixture. The process is preferably suitable for the preparation of N-phosphono- methylglycine and derivatives thereof, which are significant in plant protection as herbicidally active compounds.

Способ получения сухого фитоактивного аммоний-n-фосфонометилглицина

Описывается способ получения сухого фитоактивного аммоний-N-фосфонометилглицина, способного к высокому наполнению одним или несколькими адьювантами, который включает взаимодействие водного гидроксида аммония с влажной лепешкой N-фосфонометилглицина в системе подходящего реактора с образованием реакционной массы, в которой содержание влаги непрерывно снижается в процессе реакции. Технический результат - возможность получения неслеживающейся гербицидной композиции. 2 с. и 18 з.п.ф-лы, 1 ил. 6бЕЗ7УЭсС ПЧ с» РОССИЙСКОЕ АГЕНТСТВО ПО ПАТЕНТАМ И ТОВАРНЫМ ЗНАКАМ (19) ВИ” 2 164 519 67 МК’ С 07Е 9/38 (13) С2 (12) ОПИСАНИЕ ИЗОБРЕТЕНИЯ К ПАТЕНТУ РОССИЙСКОЙ ФЕДЕРАЦИИ (21), (22) Заявка: 98100223/04, 05.03.1996 (24) Дата начала действия патента: 05.03.1996 (30) Приоритет: 07.06.1995 Ц$ 472,152 (43) Дата публикации заявки: 27.10.1999 (46) Дата публикации: 27.03.2001 (56) Ссылки: ММО 90/07275 А\, 12.07.1990. ЕВ 2692439 АЛ, 24.12.1993. ЕР 0238240 А2, 23.09.1987. КУ 20381790 СЛ, 09.07.1995. (85) Дата перевода заявки РСТ на национальную фазу: 08.01.1998 (86) Заявка РСТ: 0$ 96/03081 (05.03.1996) (87) Публикация РСТ: \М/О 96/40696 (19.12.1996) (98) Адрес для переписки: 129010, Москва, ул. Большая Спасская 25, стр.3, ООО "Городисский и Партнеры", Лебедевой Н.Г. (71) Заявитель: МОНСАНТО КОМПАНИ (1$) (72) Изобретатель: Томас МакКабе ДЭЙ (3), Джейн Лаура ДЖИЛЛСПАЙ (1$), Ричард Мелвин КРАМЕР (1$), Ральф Элмер ЛИНДЕМАНН, мл. (($) (73) Патентообладатель: МОНСАНТО КОМПАНИ (0$) (74) Патентный поверенный: Лебедева Наталья Георгиевна (54) СПОСОБ ПОЛУЧЕНИЯ СУХОГО ФИТОАКТИВНОГО АММОНИЙ-М-ФОСФОНОМЕТИЛГЛИЦИНА (57) Описывается способ получения сухого фитоактивного аммоний-М-фосфонометилглицина, способного к высокому наполнению одним или несколькими адьювантами, который включает взаимодействие водного гидроксида аммония с влажной лепешкой М-фосфонометилглицина в системе подходящего реактора с образованием реакционной массы, в которой содержание влаги непрерывно снижается в процессе реакции. Технический ...

Method for preparing n-phosphonomethylglycine

FIELD: organic chemistry, chemical technology. SUBSTANCE: invention relates to a method for preparing N-phosphonomethylglycine. Invention describes a method for preparing N-phosphonomethylglycine from an aqueous mixture containing dissolved N-phosphonomethylglycine, ammonium halides, alkali or earth-alkali metal halides and, optionally, organic impurities. Method involves (a) using a mixture with pH value from 2 to 8; (b) separation of mixture is carried out on a selective nanofiltration membrane, and retentate enriched with N-phosphonomethylglycine and depleted with halides and permeate depleted with N-phosphonomethylglycine are obtained, and (c) N-phosphonomethylglycine is isolated from retentate. Method provides preparing N-phosphonomethylglycine in simultaneous separation of halide salts. EFFECT: improved preparing method. 13 cl, 5 dwg, 2 tbl, 2 ex ÐÎÑÑÈÉÑÊÀß ÔÅÄÅÐÀÖÈß RU (19) (11) 2 274 641 (13) C2 (51) ÌÏÊ C07F 9/38 (2006.01) ÔÅÄÅÐÀËÜÍÀß ÑËÓÆÁÀ ÏÎ ÈÍÒÅËËÅÊÒÓÀËÜÍÎÉ ÑÎÁÑÒÂÅÍÍÎÑÒÈ, ÏÀÒÅÍÒÀÌ È ÒÎÂÀÐÍÛÌ ÇÍÀÊÀÌ (12) ÎÏÈÑÀÍÈÅ ÈÇÎÁÐÅÒÅÍÈß Ê ÏÀÒÅÍÒÓ (21), (22) Çà âêà: 2004101770/04, 21.06.2002 (24) Äàòà íà÷àëà îòñ÷åòà ñðîêà äåéñòâè ïàòåíòà: 21.06.2002 (30) Ïðèîðèòåò: 22.06.2001 (ïï.1-13) DE 10130136.7 (72) Àâòîð(û): ÔÀÍÄÅÍÌÅÐØ Õóãóåñ (DE), ÔÎÑÑ Õàðòâèõ (DE), ÎÐÑÒÅÍ Øòåôàí (DE), ÂÓËÜÔÔ Êðèñòèàí (DE) (45) Îïóáëèêîâàíî: 20.04.2006 Áþë. ¹ 11 2 2 7 4 6 4 1 (56) Ñïèñîê äîêóìåíòîâ, öèòèðîâàííûõ â îò÷åòå î ïîèñêå: IT 1281094 Â, 23.06.1997. ÅÐ 0806428 À, 12.11.1997. WO 9633005 À, 24.10.1996. SU 1282820 A3, 07.01.1987. DE 2528633 À, 05.02.1976. (85) Äàòà ïåðåâîäà çà âêè PCT íà íàöèîíàëüíóþ ôàçó: 22.01.2004 2 2 7 4 6 4 1 R U (87) Ïóáëèêàöè PCT: WO 03/000704 (03.01.2003) C 2 C 2 (86) Çà âêà PCT: EP 02/06903 (21.06.2002) Àäðåñ äë ïåðåïèñêè: 103064, Ìîñêâà, óë. Êàçàêîâà, 16, ÍÈÈÐ Êàíöåë ðè "Ïàòåíòíûå ïîâåðåííûå Êâàøíèí, Ñàïåëüíèêîâ è ïàðòíåðû", Â.Ï.Êâàøíèíó (54) ÑÏÎÑÎÁ ÏÎËÓ×ÅÍÈß N-ÔÎÑÔÎÍÎÌÅÒÈËÃËÈÖÈÍÀ (57) Ðåôåðàò: Èçîáðåòåíèå îòíîñèòñ ê ñïîñîáó ïîëó÷åíè Nôîñôîíîìåòèëãëèöèíà. ...

Preparation of ammonium glyphosate using aqueous ammonium hydroxide in a liquid-solid reaction system

고체 N-포스포노메틸글리신 또는 글리포세이트산을 상당히 밀폐된 시스템에 채운 후에, 열풍 그라인딩/건조 시스템을 통해 연속적으로 재순환시켜서 부분적으로 사전-건조한다. 그후에 냉각된 수산화암모늄 용액을 계량주입하고, 생성된 반응물의 수분함량이 반응내내 연속적으로 감소되도록 하는 방법으로 재순환시켜서 부분적으로 건조된 글리포세이트산과 반응시킨다. 수산화암모늄의 첨가가 완결된 다음에, 약 2중량%의 수분함량을 갖는 분말화된 반응물/생성물이 생성된다. 이 단계에서, 중요하게도 암모늄 글리포세이트 생성물은 최종 사용에 상당히 적합하며, 이는 쉽게 물에 용해되어 즉시 제초제 또는 식물 성장 조절제로 사용될 수 있다. 그러나, 더 중요한 것은, 이 생성물은 고도의 흡수성 특성 때문에 보조제들, 특히 계면활성제들이 매우 고농도로 첨가된 생성물로 더 제제화될 수 있다는 것이다. After solid N-phosphonomethylglycine or glyphosate acid is filled in a highly closed system, it is partially pre-dried by continuous recycling through a hot air grinding / drying system. The cooled ammonium hydroxide solution is then metered in and recycled to react with the partially dried glyphosate acid in such a way that the water content of the resulting reactants is continuously reduced throughout the reaction. After the addition of ammonium hydroxide is complete, a powdered reactant / product is produced having a water content of about 2% by weight. At this stage, importantly, the ammonium glyphosate product is quite suitable for the end use, which can be readily dissolved in water and used immediately as a herbicide or plant growth regulator. However, more importantly, this product can be further formulated into products with very high concentrations of auxiliaries, in particular surfactants, due to their highly absorbent properties.

Oxidation catalyst and process

This invention relates to the field of heterogeneous catalysis, and more particularly to catalysts including carbon supports having formed thereon compositions which comprise a transition metal in combination with nitrogen and/or carbon. The invention further relates to the fields of catalytic oxidation, including the preparation of secondary amines by the catalytic oxidation of tertiary amines.

Transition metal-containing catalysts and catalyst combinations including transition metal-containing catalysts and processes for their preparation and use as oxidation catalysts

아미노 카르복실산의 제조방법

본 발명은 카르복시메틸화 반응에 의해 N-아실 아미노 카르복실산을 제조하는 방법에 관한 것이다. 상기 반응에서, 염기쌍, 일산화탄소, 수소 및 카르바모일 화합물 및 카르복시메틸화 촉매 전구체를 함유하는 염기쌍을 갖는 알데히드를 함유하는 반응 혼합물을 형성한다. 바람직한 구현예로는, 카르바모일 화합물 및 알데히드를 선택하여 N-(포스포노메틸)글리신으로 용이하게 전환되는 N-아실 아미노 카르복실산, 또는 그의 염 또는 에스테르를 수득한다.

Process for purifying aminoethylenephosphonic acids for pharmaceutical use

내용 없음. No content.

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Способ получения порошка глифозата аммония

Method for preparing n-phosphonomethylglycine

FIELD: organic chemistry, chemical technology. SUBSTANCE: invention relates to a novel method for synthesis of N-phosphonomethylglycine. Method involves interaction of hexahydrotriazine compound with triacyl phosphite in organic solvent, saponification of formed phosphonic compound after preliminary extraction into aqueous phase, separation of organic phase and precipitation of N-phosphonomethylglycine by pH value control in the range from 0.5 to 2.0. Invention prevents decomposition of an organic solvent in saponification. EFFECT: improved method of synthesis. 8 cl, 3 tbl, 4 ex

Method of producing n-phosphonomethylglycine

N-phosphonomethylglycine is prepared from glycine and parsformaldehyde to obtain an intermediate which is reacted with dialkylphosphite to obtain an ester of the desired compound which is then hydrolyzed.

Method for recovering N-phosphonomethylglycine

在草甘膦的生产中对n-(膦酰甲基)亚氨基二乙酸转化率的控制

本发明涉及从N‑(膦酰基甲基)亚氨基二乙酸(“PMIDA”)制备N‑(膦酰基甲基)甘氨酸(“草甘膦”)的方法，更特别地涉及控制PMIDA的转化率的方法、确认与PMIDA转化率相关的反应终点的方法和制备具有受控PMIDA含量的草甘膦产物的方法。

Herbicide

Method of dry glyphosate ammonium producing

FIELD: agriculture, herbicides. SUBSTANCE: invention describes method of production of dry glyphosate ammonium involving addition of anhydrous gaseous ammonia to medium containing glyphosate acid as a moist "tablet" under condition of constant temperature about 60 C, not above. In the process of reaction carrying out gas is dispersed in acid uniformly and heat removal from reaction is optimized. Produced glyphosate ammonium is a water- -soluble powder with high sorption capacity that can be used for final using as a regulating agent of plant growth or as herbicide without further processing. Product is especially useful for further formulation for absorption/adsorption of adjuvants, for example, wetting agents, foam suppressors and, especially, surface-active substances being used in extremely high concentrations. EFFECT: improved method of production. 20 cl ЗРЕЗУЭГЕС ПЧ с» РОССИЙСКОЕ АГЕНТСТВО ПО ПАТЕНТАМ И ТОВАРНЫМ ЗНАКАМ (19) ВИ” 2 164 518 67 МК’ С 07Е 9/38 (13) С2 (12) ОПИСАНИЕ ИЗОБРЕТЕНИЯ К ПАТЕНТУ РОССИЙСКОЙ ФЕДЕРАЦИИ (21), (22) Заявка: 98100186/04, 05.03.1996 (24) Дата начала действия патента: 05.03.1996 (30) Приоритет: 07.06.1995 Ц$ 485,316 (43) Дата публикации заявки: 27.10.1999 (46) Дата публикации: 27.03.2001 (56) Ссылки: ММО 90/07275 А\, 12.07.1990. ЕВ 2692439 АЛ, 24.12.1993. ЕР 0238240 А2, 23.09.1987. КУ 20381790 СЛ, 09.07.1995. (85) Дата перевода заявки РСТ на национальную фазу: 08.01.1998 (86) Заявка РСТ: 0$ 96/03082 (05.03.1996) (87) Публикация РСТ: \М/О 96/40697 (19.12.1996) (98) Адрес для переписки: 129010, Москва, ул. Большая Спасская 25, стр.3, ООО "Городисский и Партнеры", Лебедевой Н.Г. (71) Заявитель: МОНСАНТО КОМПАНИ (1$) (72) Изобретатель: Томас МакКабе ДЭЙ (Ц$), Джейн Лаура ДЖИЛЛСПАИ (0$), Ричард Мелвин КРАМЕР (05$) (73) Патентообладатель: МОНСАНТО КОМПАНИ (0$) (74) Патентный поверенный: Лебедева Наталья Георгиевна (54) СПОСОБ ПОЛУЧЕНИЯ СУХОГО АММОНИЙ-ГЛИФОСАТА (57) Описывается способ получения сухого аммоний-глифосата, включающий ...

Process for the preparation of n-phosphono methylglycine sesquisodium salt

Title compd. (I) wherein the molar ratio of sodium cation to acid substantially 1.5-1 was prepd. by reaction of N-phosphonomethylglycine(II) and base donating 1.25-1.75 mol Na per I. I(5.6 kg/ha postemergence) completely controlled lambsquater, smartweed, quackgrass and barnyardgrass 4 week after application. Application of I(0.8 kg/ha) produced a Pol% of 14.89 in sugarcane relative to 8.11 in untreated controls.

CONTINUOUS METHOD FOR THE PREPARATION OF N PHOSPHONOMETHYLGLYCIN

Oxidation catalyst and process

This invention relates to the field of heterogeneous catalysis, and more particularly to catalysts including carbon supports having formed thereon compositions which comprise a transition metal in combination with nitrogen and/or carbon. The invention further relates to the fields of catalytic oxidation, including the preparation of secondary amines by the catalytic oxidation of tertiary amines.

Transition metal-containing catalysts and processes for their preparation and use as oxidation and dehydrogenation catalysts

This invention relates to the field of heterogeneous catalysis, and more particularly to catalysts including carbon supports having formed thereon compositions which comprise a transition metal in combination with nitrogen and/or carbon. The invention further relates to the fields of catalytic oxidation and dehydrogenation reactions, including the preparation of secondary amines by the catalytic oxidation of tertiary amines and the preparation of carboxylic acids by the catalytic dehydrogenation of alcohols.

Oxidation catalyst and process

An oxidation catalyst is prepared by pyrolyzing a source of iron and a source of nitrogen on a carbon support. Preferably, a noble metal is deposited over the modified support which comprises iron and nitrogen bound to the carbon support. The catalyst is effective for oxidation reactions such as the oxidative cleavage of tertiary amines to produce secondary amines, especially the oxidation of N-(phosphonomethyl)iminodiacetic acid to N-(phosphonomethyl)-glycine.

Transition metal-containing catalysts and catalyst combinations including transition metal-containing catalysts and processes for their preparation and use as oxidation catalysts

This invention relates to the field of heterogeneous catalysis, and more particularly to catalysts including carbon supports having compositions which comprise one or more transition metals in combination with nitrogen and/or carbon formed on or over the surface of the carbon support. The present invention also relates to catalyst combinations comprising catalysts including carbon supports having compositions which comprise one or more transition metals in combination with nitrogen and/or carbon formed on or over the surface of a carbon support and a secondary catalyst or, co-catalyst, including a secondary transition metal. The invention further relates to the field of catalytic oxidation reactions, including the preparation of secondary amines by the catalytic oxidation of tertiary amines.

Oxidation catalyst and process

This invention relates to the field of heterogeneous catalysis, and more particularly to catalysts including carbon supports having formed thereon compositions which comprise a transition metal in combination with nitrogen and/or carbon. The invention further relates to the fields of catalytic oxidation, including the preparation of secondary amines by the catalytic oxidation of tertiary amines.

Oxidation catalyst and process

An oxidation catalyst is prepared by pyrolyzing a source of iron and a source of nitrogen on a carbon support. Preferably, a noble metal is deposited over the modified support which comprises iron and nitrogen bound to the carbon support. The catalyst is effective for oxidation reactions such as the oxidative cleavage of tertiary amines to produce secondary amines, especially the oxidation of N-(phosphonomethyl)iminodiacetic acid to N-(phosphonomethyl)-glycine.

Transition metal-containing catalysts and processes for their preparation and use as oxidation and dehydrogenation catalysts

This invention relates to the field of heterogeneous catalysis, and more particularly to catalysts including carbon supports having formed thereon compositions which comprise a transition metal in combination with nitrogen and/or carbon. The invention further relates to the fields of catalytic oxidation and dehydrogenation reactions, including the preparation of secondary amines by the catalytic oxidation of tertiary amines and the preparation of carboxylic acids by the catalytic dehydrogenation of alcohols.

Transition metal-containing catalysts and processes for their preparation and use as oxidation and dehydrogenation catalysts

This invention relates to the field of heterogeneous catalysis, and more particularly to catalysts including carbon supports having formed thereon compositions which comprise a transition metal in combination with nitrogen and/or carbon. The invention further relates to the fields of catalytic oxidation and dehydrogenation reactions, including the preparation of secondary amines by the catalytic oxidation of tertiary amines and the preparation of carboxylic acids by the catalytic dehydrogenation of alcohols.

Transition metal-containing catalysts and processes for their preparation and use as oxidation and dehydrogenation catalysts

This invention relates to the field of heterogeneous catalysis, and more particularly to catalysts including carbon supports having formed thereon compositions which comprise a transition metal in combination with nitrogen and/or carbon. The invention further relates to the fields of catalytic oxidation and dehydrogenation reactions, including the preparation of secondary amines by the catalytic oxidation of tertiary amines and the preparation of carboxylic acids by the catalytic dehydrogenation of alcohols.

Transition metal-containing catalysts and catalyst combinations including transition metal-containing catalysts and processes for their preparation and use as oxidation catalysts

This invention relates to the field of heterogeneous catalysis, and more particularly to catalysts including carbon supports having compositions which comprise one or more transition metals in combination with nitrogen and/or carbon formed on or over the surface of the carbon support. The present invention also relates to catalyst combinations comprising catalysts including carbon supports having compositions which comprise one or more transition metals in combination with nitrogen and/or carbon formed on or over the surface of a carbon support and a secondary catalyst or, co-catalyst, including a secondary transition metal. The invention further relates to the field of catalytic oxidation reactions, including the preparation of secondary amines by the catalytic oxidation of tertiary amines.

Transition metal-containing catalysts and catalyst combinations including transition metal-containing catalysts and processes for their preparation and use as oxidation catalysts

This invention relates to the field of heterogeneous catalysis, and more particularly to catalysts including carbon supports having compositions which comprise one or more transition metals in combination with nitrogen and/or carbon formed on or over the surface of the carbon support. The present invention also relates to catalyst combinations comprising catalysts including carbon supports having compositions which comprise one or more transition metals in combination with nitrogen and/or carbon formed on or over the surface of a carbon support and a secondary catalyst or, co-catalyst, including a secondary transition metal. The invention further relates to the field of catalytic oxidation reactions, including the preparation of secondary amines by the catalytic oxidation of tertiary amines.

로듐 촉매를 사용한 히드로포르밀화에 의한 알데히드의제조 방법 및 추출에 의한 로듐 촉매의 회수 방법

본 발명은 50 내지 1,000 bar의 압력 및 50 내지 180 ℃의 온도에서 균질한 반응 매질에 용해되어 있는 로듐 촉매를 사용하여 올레핀을 히드로포르밀화하는 히드로포르밀화 단계, 및 킬레이트화제 수용액을 사용한 로듐 촉매의 추출, 추출된 히드로포르밀화 생성물 스트림으로부터 알콜 및(또는) 알데히드의 분리, 50 내지 1,000 bar의 압력 및 50 내지 180 ℃의 온도에서 일산화 탄소, 합성 가스, 또는 일산화 탄소를 함유하는 가스 혼합물의 존재 하에 수성 로듐-함유 추출물의 예비카르보닐화, 로듐의 주요 부분을 함유하는 유기상 및 킬레이트화제를 함유하는 수상으로 예비카르보닐화 단계의 유출물의 분리, 유기상의 히드로포르밀화 단계로의 재순환으로 구성되는 촉매 회수 단계를 포함하는, 3 개 초과의 탄소 원자를 함유하는 올레핀의 히드로포르밀화에 의한 알데히드 또는 알데히드 및 알콜의 제조 방법에 있어서, 로듐을 킬레이트화할 수 있는 술폰산기가 없는, 수용성, 중합체 수용액을 사용하여 로듐 촉매를 히드로포르밀화 단계의 유출물로부터 추출하는 것을 특징으로 하는 방법을 제공한다.

Phosphonate ester official for metal surface can antimicrobial coating

本发明涉及包含单‑、二‑、三‑或四‑膦酸酯季铵化合物的抗微生物组合物，和涂覆有该组合物的表面，该组合物对多种革兰氏阳性和革兰氏阴性菌，包括但不限于葡萄球菌(Staphylococcus)、假单胞菌(Pseudomonas)、克雷伯氏菌(Klebsiella)、沙门氏菌(Salmonella)和利斯特氏菌(Listeria)、节杆菌(Arthrobacter)和埃希氏菌(Escherichia)，表现出抗微生物活性。

Novel process and synthesis device for preparing glyphosate by hydrolyzing by-product acid instead of hydrochloric acid

本发明公开了一种副产酸代替盐酸水解制备草甘膦新工艺与合成装置，包括以下步骤：(1)以甘氨酸，亚磷酸二甲酯，多聚甲醛为原料，甲醇为溶剂，三乙胺为催化剂制备合成液L1；(2)在合成液L1中加入后处理盐酸进行水解脱溶，水解脱溶结束后加碱调节pH；(3)加入去离子水，降温搅拌结晶得到结晶液L2，洗涤烘干后得到草甘膦成品；本发明在甘氨酸‑烷基酯法生产草甘膦的基础上进行改进采用制备三氯化磷的副产盐酸经过后处理后代替盐酸进行合成液的水解，与此同时优化了各关键工艺指标参数，不仅提升了化工园区副产酸的利用率，而且草甘膦原粉收率和纯度得到极大地提升。同时，由于避免了盐酸的引入所携带的大量水分，也降低了甲醇等副产回收能耗和废水排放量。

Method of increasing hydrocarbon production from subterranean formations

A method of treating a carbonate-containing subterranean formation to increase the production of hydrocarbons therefrom. The formation is contacted with an aqueous solution of one or more of certain anionic aminophosphonate compounds whereby the composition is caused to be absorbed onto the solid surfaces present in the subterranean limestone-containing formation and substantially reduces the tendency of such surfaces from becoming water or hydrocarbon wet.

Method of preparing n-phosphonomethylglycine mono- or di-salts

Process for the preparation of n-phosphonomethyl glycine

내용 없음. No content.

Patent JPH0377463B2

N1,n1,n4,n4-tetramethyl-2-butyne-1,4-diamine salt with n-phosphonomethylglycine, showing herbicid activity and the method of its production

FIELD: chemistry. SUBSTANCE: N 1 ,N 1 ,N 4 ,N 4 -tetramethyl-2-butyne-1,4-diamine salt is proposed with N-phosphonomethylglycine of the formula (1), which is obtained by reacting N 1 ,N 1 ,N 4 ,N 4 -tetramethyl-2-butyne-1,4-diamine with an equimolar amount of an aqueous solution of N-phosphonomethylglycine at 20-25°C and stirred for 2.5-3.0 h. EFFECT: new compound is provided; it is effective as a herbicide for control of annual and perennial monocotyledonous and dicotyledonous weeds, as well as a new effective method for its preparation. 5 cl, 5 ex, 3 tbl РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 2 619 948 C1 (51) МПК A01N 57/20 (2006.01) C07F 9/38 (2006.01) C07C 211/23 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ФОРМУЛА (21)(22) Заявка: ИЗОБРЕТЕНИЯ К ПАТЕНТУ РОССИЙСКОЙ ФЕДЕРАЦИИ 2016120787, 26.05.2016 (24) Дата начала отсчета срока действия патента: 26.05.2016 Дата регистрации: Приоритет(ы): (22) Дата подачи заявки: 26.05.2016 C 1 (56) Список документов, цитированных в отчете о поиске: RU 2408572 C2, 10.01.2011. UA C 1 Адрес для переписки: 450029, Респ. Башкортостан, г. Уфа, ул. Ульяновых, 65, НИТИГ (73) Патентообладатель(и): Федеральное государственное бюджетное учреждение науки Институт нефтехимии и катализа Российской академии наук (RU), Государственное бюджетное учреждение Республики Башкортостан "Научно-исследовательский технологический институт гербицидов и регуляторов роста растений с опытно-экспериментальным производством Академии наук Республики Башкортостан" (RU) 2 6 1 9 9 4 8 (45) Опубликовано: 22.05.2017 Бюл. № 15 (54) Соль N1, N1, N4, N4-тетраметил-2-бутин-1,4-диамина с N-фосфонометилглицином, проявляющая гербицидную активность и способ ее получения (57) Формула изобретения 1. Химическое соединение структурной формулы R U 2 6 1 9 9 4 8 26394 C2, 30.08.1999. WO 2014095785 A1, 26.06.2014. 2. Химическое соединение по п. 1, которое проявляет гербицидную активность. 3. Химическое соединение по п. 1, которое проявляет гербицидную ...

Process for the production of N-phosphonomethylglycine

Process for producing N-phosphonomethylglycine

A process for the production of N-phosphonomethylglycine comprising contacting N-phosphonomethyliminodiacetic acid with a molecular oxygen-containing gas in the presence of a catalyst selected from the group consisting of the salts and salt complexes of manganese, cobalt, iron, nickel, chromium, ruthenium, aluminum, molybdenum, vanadium and cerium, and an effective amount of a dipyridyl compound.

Process for catalytically synthesizing glyphosate

一种合成草甘膦的有机催化剂，该催化剂为包括第一主族碱金属的烷氧基化合物，还包括新鲜无水甲醇、乙醇和第钾、钠金属或钾、钠的无水氢氧化物或氧化物配制或碱金属反应配制的烷氧基金属化合物，并以该烷氧基金属化合物醇溶液形式存在的一种或多种的组合。合成草甘膦的工艺，多聚甲醛或甲醛的甲醇溶液经添加有机催化剂后进行解聚反应，反应完成后加入三乙胺、甘氨酸搅拌进行加成反应；反应完成后加入亚磷酸二甲酯进行缩合反应，反应完成后加入盐酸水解，再经结晶、洗料、烘干得到草甘膦。使用特定的催化剂提高草甘膦合成反应速度及反应选择性，解聚反应速度快、反应彻底，加成反应选择性也高，草甘膦产品收率高5%以上，具有反应优势、节能优势、成本优势、环保优势。

METHOD FOR PRODUCING N-PHOSPHONOMETHYLGLYCIN

ÐÎÑÑÈÉÑÊÀß ÔÅÄÅÐÀÖÈß (19) RU (51) ÌÏÊ 7 (11) 2004 101 773 (13) A C 07 F 9/38 ÔÅÄÅÐÀËÜÍÀß ÑËÓÆÁÀ ÏÎ ÈÍÒÅËËÅÊÒÓÀËÜÍÎÉ ÑÎÁÑÒÂÅÍÍÎÑÒÈ, ÏÀÒÅÍÒÀÌ È ÒÎÂÀÐÍÛÌ ÇÍÀÊÀÌ (12) ÇÀßÂÊÀ ÍÀ ÈÇÎÁÐÅÒÅÍÈÅ (21), (22) Çà âêà: 2004101773/04, 21.06.2002 (71) Çà âèòåëü(è): ÁÀÑÔ ÀÊÖÈÅÍÃÅÇÅËËÜØÀÔÒ (DE) (30) Ïðèîðèòåò: 22.06.2001 DE 10130135.9 (43) Äàòà ïóáëèêàöèè çà âêè: 27.06.2005 Áþë. ¹ 18 (86) Çà âêà PCT: EP 02/06902 (21.06.2002) (74) Ïàòåíòíûé ïîâåðåííûé: Êâàøíèí Âàëåðèé Ïàâëîâè÷ Àäðåñ äë ïåðåïèñêè: 103064, Ìîñêâà, óë. Êàçàêîâà,16, ÍÈÈÐ Êàíöåë ðè "Ïàòåíòíûå ïîâåðåííûå Êâàøíèí, Ñàïåëüíèêîâ è ïàðòíåðû", Â.Ï.Êâàøíèíó R U Ôîðìóëà èçîáðåòåíè 1. Ñïîñîá ïîëó÷åíè N-ôîñôîíîìåòèëãëèöèíà, ïðè êîòîðîì à) ïðîèçâîäíîå ãåêñàãèäðîòðèàçèíà ôîðìóëû II A 2 0 0 4 1 0 1 7 7 3 A (54) ÑÏÎÑÎÁ ÏÎËÓ×ÅÍÈß N-ÔÎÑÔÎÍÎÌÅÒÈËÃËÈÖÈÍÀ 2 0 0 4 1 0 1 7 7 3 (87) Ïóáëèêàöè PCT: WO 03/000703 (03.01.2003) ãäå Õ îçíà÷àåò CN, COOZ, CONR 1R 2 èëè CH2OY; Y îçíà÷àåò Í èëè îñòàòîê, êîòîðûé ëåãêî çàìåíèì íà Í; Z îçíà÷àåò Í, ùåëî÷íîé ìåòàëë, ùåëî÷íîçåìåëüíûé ìåòàëë, C1-C18-àëêèë èëè àðèë, êîòîðûé íåîá çàòåëüíî çàìåùåí Ñ1-Ñ4-àëêèëîì, NO2 èëè ÎÑ1-Ñ4-àëêèëîì; R 1 è R 2, êîòîðûå ìîãóò áûòü îäèíàêîâûìè èëè ðàçëè÷íûìè, îçíà÷àþò Í èëè Ñ1-Ñ4-àëêèë, ïîäâåðãàþò âçàèìîäåéñòâèþ ñ òðèàöèëôîñôèòîì ôîðìóëû III Ð(OCOR 3)3, (III) ãäå îñòàòêè R 3, êîòîðûå ìîãóò áûòü îäèíàêîâûìè èëè ðàçëè÷íûìè, îçíà÷àþò C1-C18-àëêèë èëè àðèë, êîòîðûé íåîá çàòåëüíî çàìåùåí Ñ1-Ñ4-àëêèëîì, NO 3 èëè ÎÑ1-Ñ4-àëêèëîì, â îðãàíè÷åñêîì ðàñòâîðèòåëå, á) ïîëó÷åííóþ ðåàêöèîííóþ ñìåñü ýêñòðàãèðóþò âîäîé èëè âîäíûì ðàñòâîðîì êèñëîòû èëè âîäíûì ðàñòâîðîì îñíîâàíè , Ñòðàíèöà: 1 RU R U (85) Äàòà ïåðåâîäà çà âêè PCT íà íàöèîíàëüíóþ ôàçó: 22.01.2004 (72) Àâòîð(û): ÂÓËÜÔÔ Êðèñòèàí (DE), ÎÐÑÒÅÍ Øòåôàí (DE), ÎÔÒÐÈÍà Àëüôðåä (DE), ÖÅÍÅÐ Ïåòåð (DE) A 2 0 0 4 1 0 1 7 7 3 R U A 2 0 0 4 1 0 1 7 7 3 R U â) ðàçäåë þò ôàçû è ã) ñîäåðæàùèéñ â âîäíîé ôàçå ïðîäóêò ãèäðîëèçóþò. 2. Ñïîñîá ïî ï.1, ïðè êîòîðîì ñîãëàñíî ñòàäèè (ã) N-ôîñôîíîìåòèëãëèöèí ïîëó÷àþò èç âîäíîé ôàçû. 3. Ñïîñîá ïî ï.2, ïðè êîòîðîì N ...

Method for synthesis of n-(phosphonomethyl)glycine

FIELD: chemistry.SUBSTANCE: invention relates to a method for the synthesis of N-(phosphonomethyl)glycine and can be used in the chemical industry. Disclosed method for the synthesis of N-(phosphonomethyl)glycine or a salt thereof includes the following steps: a) forming, in the presence of an acid catalyst, a reaction mixture containing 2,5-diketopiperazine, formaldehyde and a compound containing one or more P-O-P anhydride moieties, wherein said moieties contain one P atom in the oxidation state (+III) and another P atom in the oxidation state (+III) or (+V), to form N,N'-bisphosphonomethyl-2,5-diketopiperazine, wherein the compound containing one or more P-O-P anhydride moieties, where said moieties contain one P atom in oxidation state (+III) and another P atom in oxidation state (+III) or (+V), is selected from tetraphosphorus hexoxide, PO, PO, PO, tetraphosphate decaoxide, tetraethyl pyrophosphite, dimethyl phosphite, and combinations thereof; and b) hydrolysing said N,N'-bisphosphonomethyl-2,5-diketopiperazine to obtain N-(phosphonomethyl)glycine or a salt thereof, wherein if the hydrolysis is carried out under basic conditions, the N-(phosphonomethyl)glycine salt contains a carboxylate and/or phosphonate anion of N-(phosphonomethyl)glycine and an alkali metal, alkali-earth metal or ammonium cation; if the hydrolysis is carried out under acidic conditions, the salt of N-(phosphonomethyl)glycine or salt thereof contains the ammonium cation of N-(phosphonomethyl)glycine and the anion, which passes from the acid used for the hydrolysis; and/or the cation of the salt of N-(phosphonomethyl)glycine is selected from the group consisting of ammonium, isopropylammonium, ethanolammonium, dimethylammonium, trimethylsulphonium, alkali or alkali-earth metal.EFFECT: novel efficient method for obtaining N-(phosphonomethyl)glycine is disclosed.49 cl, 42 ex РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 2 674 021 C9 (51) МПК C07F 9/38 (2006.01) A01N 57/20 (2006.01) ...

Method for synthesis of n-(phosphonomethyl)glycine

FIELD: chemistry. SUBSTANCE: invention relates to a method for the synthesis of N-(phosphonomethyl)glycine or a salt thereof – highly effective phytotoxic agent. Method includes the following steps: a) forming a reaction mixture containing an acid catalyst, N,N'-bis(carboxymethyl)-2,5-diketopiperazine and a compound containing one or more P-O-P anhydride moieties, where said moieties contain one P atom in the oxidation state (+III) and another P atom in the oxidation state (+III) or (+V), to form N,N'-bis(phosphonomethyl)-2,5-diketopiperazine, wherein the compound containing one or more P-O-P anhydride moieties, where said moieties contain one P atom in oxidation state (+III) and another P atom in oxidation state (+III) or (+V), is selected from tetraphosphorus hexaoxide, P 4 O 7 , P 4 O 8 , P 4 O 9 , tetraphosphorus decaoxide, tetraethyl pyrophosphite, dimethyl phosphite, and combinations thereof; and b) hydrolysis of the reaction mixture to form N-(phosphonomethyl)glycine or a salt thereof. If hydrolysis is carried out under basic conditions, the salt contains a carboxylate and/or phosphonate anion of N-(phosphonomethyl)glycine and an alkali metal, alkaline earth metal or ammonium cation; if hydrolysis is carried out under acidic conditions, the salt contains the ammonium cation of N-(phosphonomethyl)glycine and the anion, which passes from the acid used for the hydrolysis; and/or the cation of the salt of N-(phosphonomethyl)glycine is selected from the group consisting of ammonium, isopropylammonium, ethanolammonium, dimethylammonium, trimethylsulphonium, alkali or alkali-earth metal. EFFECT: disclosed method enables to obtain the desired product using high-performance and environmentally friendly technology. 28 cl, 1 tbl, 1 ex РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 2 674 023 C2 (51) МПК C07F 9/38 (2006.01) A01N 57/20 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ОПИСАНИЕ ИЗОБРЕТЕНИЯ К ПАТЕНТУ (52) СПК C07F 9/38 (2006.01); A01N 57/20 ...

Method of producing alkylaminoalkylene phosphonic acids

FIELD: chemistry. SUBSTANCE: invention relates to a method of producing alkylaminoalkylene phosphonic acids of formula U-[X-N(W)(ZPO 3 M 2 )] S , which can be used in chemical industry. The disclosed method involves reacting a compound of formula Y-X-N(W)(ZPO 3 M 2 ) with a precursor for groups U, selected from NH 3 , NH 2 R', NH(R') 2 , HOR', NaOH, Na 2 S, thiourea and Na 2 S 2 , where Y is chlorine, X is a C 2 -C 3 linear alkyl, Z is C 1 alkylene, M is H; W is ZPO 3 M 2 , U is selected from NH 2 , NHR', N(R') 2 , NH, N, OH, OR', S, SH and S-S, R' is phenyl or a C 1 -C 3 linear alkyl, s equals 1, if U is NH 2 , NHR', N(R') 2 , HS, OR or OH; s equals 2, if U is NH, S or S-S; and s equals 3, if U is N, in an aqueous medium at pH 8 or higher, at temperature from 10°C to 110°C. EFFECT: novel efficient method of producing alkylaminoalkylene phosphonic acids. 3 cl, 14 ex РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) 2 498 989 (13) C2 (51) МПК C07F 9/38 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ОПИСАНИЕ ИЗОБРЕТЕНИЯ К ПАТЕНТУ (21)(22) Заявка: 2009125468/04, 11.12.2007 (24) Дата начала отсчета срока действия патента: 11.12.2007 (73) Патентообладатель(и): ДЕКВЕСТ АГ (CH) (43) Дата публикации заявки: 20.01.2011 Бюл. № 2 2 4 9 8 9 8 9 (45) Опубликовано: 20.11.2013 Бюл. № 32 (56) Список документов, цитированных в отчете о поиске: US 4330487 A1, 18.05.1982. EP 0070534 A1, 26.01.1983. US 4707306 A1, 17.11.1987. US 4260738 A, 07.04.1981. SU 960184 A1, 23.09.1982. 2 4 9 8 9 8 9 R U (86) Заявка PCT: EP 2007/063682 (11.12.2007) C 2 C 2 (85) Дата начала рассмотрения заявки PCT на национальной фазе: 13.07.2009 (87) Публикация заявки РСТ: WO 2008/071689 (19.06.2008) Адрес для переписки: 197101, Санкт-Петербург, а/я 128, "АРСПАТЕНТ" (54) СПОСОБ ПОЛУЧЕНИЯ АЛКИЛАМИНОАЛКИЛЕНФОСФОНОВЫХ КИСЛОТ собой C1 алкилен, M представляет собой H; W представляет собой ZPO3M2, U выбран из NH2, NHR', N(R')2, NH, N, OH, OR, S, SH и S-S, R' представляет собой ...