04-09-2014 дата публикации
Номер: US20140248317A1
Принадлежит:
GLYTECH, INC.
A trehalose compound having high immunopotentiating activity and low toxicity is represented by formula (1). (In the formula, X and X′ each represents a phenyl, a naphthyl, R—CHR— (wherein Rand Reach represents a C-Calkyl group or the like) or the like; and n and n′ each independently represents an integer of 0-3). The compound exhibits a high activating effect on macrophages and neutrophils. 2. The method according to claim 1 , wherein X represents R—CHR— and X′ represents R—CHR′—.3. The method according to claim 2 , wherein R claim 2 , R′ claim 2 , Rand R′ independently represent a linear C-Calkyl group claim 2 , and n and n′ independently represent 0 or 1.4. The method according to claim 2 , wherein R claim 2 , R′ claim 2 , Rand R′ independently represent a linear C-Calkyl group claim 2 , and n and n′ independently represent 0.5. The method according to claim 2 , wherein R claim 2 , R′ claim 2 , Rand R′ independently represent a linear C-Calkyl group claim 2 , and n and n′ independently represent 1.6. The method according to claim 1 , wherein Ris identical to R′ claim 1 , Ris identical to R′ claim 1 , and n is identical to n′.7. The method according to claim 1 , wherein the compound is selected from the group consisting of:6,6′-bis-O-(2-octyldecanoyl)-α,α′-trehalose,6,6′-bis-O-(2-nonylundecanoyl)-α,α′-trehalose,6,6′-bis-O-(2-decyldodecanoyl)-α,α′-trehalose,6,6′-bis-O-(2-undecyltridecanoyl)-α,α′-trehalose,6,6′-bis-O-(2-dodecyltetradecanoyl)-α,α′-trehalose,6,6′-bis-O-(2-tridecylpentadecanoyl)-α,α′-trehalose,6,6′-bis-O-(2-pentadecylheptadecanoyl)-α,α′-trehalose, and6,6′-bis-O-(2-hexadecyloctadecanoyl)-α,α′-trehalose.8. The method according to claim 1 , wherein the compound is selected from the group consisting of:6,6′-bis-O-(3-nonyldodecanoyl)-α,α′-trehalose,6,6′-bis-O-(3-decyltridecanoyl)-α,α′-trehalose,6,6′-bis-O-(3-undecyltetradecanoyl)-α,α′-trehalose,6,6′-bis-O-(3-dodecylpentadecanoyl)-α,α′-trehalose,6,6′-bis-O-(3-tridecylhexadecanoyl)-α,α′-trehalose, and6,6′- ...
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