17-08-2017 дата публикации
Номер: US20170233437A1
Автор:
Alanine Alexander,
Beignet Julien,
Bleicher Konrad,
Fasching Bernhard,
Hilpert Hans,
Hu Taishan,
Jackson Stephen,
Kolczewski Sabine,
Kroll Carsten,
MacDonald Dwight,
Schaeublin Adrian,
Shen Hong,
Stoll Theodor,
Thomas Helmut,
Wahhab Amal,
Zampaloni Claudia
The present invention provides compounds of formula (I) 3. The compound according to any of or , wherein:{'sup': 1', '1, 'Xis CRor N,'}{'sup': 2', '12, 'Xis CRor N,'}{'sup': 3', '13, 'Xis CRor N,'}{'sup': 4', '14', '1', '2', '3', '4, 'Xis CRor N, with the proviso that not more than two of X, X, Xand Xare N;'}{'sup': 5', '15, 'Xis CRor N,'}{'sup': 6', '16, 'Xis CRor N,'}{'sup': 7', '17, 'Xis CRor N,'}{'sup': 8', '18', '5', '6', '7', '8, 'Xis CRor N, with the proviso that not more than two of X, X, Xand Xare N;'}{'sup': '1', 'sub': 2', 'm', '2', 'm', '1-7', '1-7', '3-7', '1-7, 'Ris —(CH)-heteroaryl or —(CH)— heterocycloalkyl; wherein heteroaryl is optionally substituted with one or more halo, cyano, C-alkyl, C-haloalkyl, C-cycloalkyl or C-alkoxy; and wherein heterocycloalkyl is partly unsaturated;'}{'sup': 2', '4', '6, 'sub': 1-7', '1-7', '3-7, 'R, Rand Rare each individually selected from hydrogen, C-alkyl, C-haloalkyl, and C-cycloalkyl;'}{'sup': 3', '20', '21', '20', '21', '20', '21, 'sub': 1-7', '2', 'n', '2', 'n', '2', 'n', '2', 'q, 'Ris —C-alkyl, —(CH)—NRR, —(CH)—C(O)NRRor —(CH)—O—(CH)—NRR;'}{'sup': 5', '22', '23', '22', '23, 'sub': 1-7', '1-7', '2', 'o', '2', 'o, 'claim-text': [{'sub': 2', 'o', '2', 'q', '2', 'o', '2', 'o, 'sup': 20', '21', '22', '23', '22', '23, '—(CH)—O—(CH)NRR, —(CH)—NH—C(NH)—NRR, —(CH)—NH—C(O)—NRR,'}, {'sub': 2', 'o', '2', 'o', '2', 'o', '2', 'o, 'sup': '26', '—(CH)—NH—C(O)—OR, —(CH)-heterocycloalkyl, —(CH)-heteroaryl, —(CH)-aryl,'}, {'sub': 1-7', '1-7', '1-7, 'wherein cycloalkyl, heterocycloalkyl, heteroaryl and aryl are optionally substituted by halo, cyano, C-alkyl, C-haloalkyl, C-alkoxy or aryl;'}], 'Ris hydrogen, C-alkyl, hydroxy-C-alkyl, —(CH)—NRR, —(CH)—C(O)—NRR,'}{'sup': 7', '8, 'sub': 1-7', '1-7', '3-7', '1-7, 'Rand Rare each individually selected from hydrogen, C-alkyl, C-haloalkyl, C-cycloalkyl and C-alkoxy;'}{'sup': 11', '12', '13', '14', '15', '16', '24', '25', '24', '25, 'sub': 1-7', '1-7', '1-7', '1-7', '1-7', '2', '3-7, ' ...
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