ФАРМАЦЕВТИЧЕСКИЕ КОМПОЗИЦИИ, ОБЛАДАЮЩИЕ ПОВЫШЕННОЙ ЭФФЕКТИВНОСТЬЮ И УЛУЧШЕННОЙ ОБРАБАТЫВАЕМОСТЬЮ

FIELD: chemistry. SUBSTANCE: invention relates to a polymer comprising hydroxypropyl methyl cellulose acetate succinate (HPMC-AS) wherein a percentage of a total degree of substitution (DS) of succinoyl in position C 6 -OH is less than or equal to 6% (C 6 C3 Suc , % ≤ 6%) and in position C 3 -OH is from 58 to 84% (58% < C 3 C3 Suc , % < 84%), and percentage of a total DS of acetyl in position C 6 -OH ranges from 33 to 51% (33% < C 6 C3 Ac , % < 51%) and in position C 3 -OH ranges from 16 to 20% (16% < C 3 C3 Ac , % < 20%). Invention relates to a composition for improving the efficiency and improving the processability of a medicament that comprises a medicament and a said polymer, as well as a process for the preparation of hydroxypropyl methyl cellulose acetate succinate (HPMC-AS) having a percentage of a total DS of succinoyl in position C 6 -OH less than or equal to 6% (C 6 C3 Suc , % ≤ 6%) and in position C 3 -OH from 58 to 84% (58% < C 3 C3 Suc , % < 84%), and a percentage of a total DS of acetyl, in position C 6 -OH of 33 to 51% (33% < C 6 C3 Ac , % < 51%) and in position C 3 -OH of 16 to 20% (16% < C 3 C3 Ac , % < 20%), comprising steps of (a) reacting acetic anhydride and sodium acetate with hydroxyl propyl methylcellulose to form an intermediate at a temperature in the range of from about 85 to about 115°C; (b) maintaining the temperature for a period of 30 minutes to 2.5 hours and (c) reacting succinic anhydride with the intermediate product at a temperature for a period of 2.5 to 23.5 hours to obtain HPMC-AS. EFFECT: increasing the effectiveness of the drug and improving processability. 10 cl, 16 dwg, 11 tbl РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 2 656 662 C2 (51) МПК C08B 13/00 (2006.01) C08L 1/32 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ОПИСАНИЕ ИЗОБРЕТЕНИЯ К ПАТЕНТУ (52) СПК A61K 31/397 (2017.08); A61K 31/4418 (2017.08); A61K 47/38 (2017.08); C08B 13/00 (2017.08); C08L 1/32 (2017.08) (21)( ...

ФИКСАТОРЫ ДЛЯ ВОЛОС, ВКЛЮЧАЮЩИЕ ПОЛИГЛЮКОЗНЫЕ ПОЛИМЕРЫ НА ОСНОВЕ ПРОСТОГО ЭФИРА ЦЕЛЛЮЛОЗЫ

TEXTILWASCHMITTEL

Improvements in or relating to the preparation of arylaminosulphonate derivatives ofnatural and synthetic polymers

Arylamino sulphonate derivatives of natural or synthetic polymeric materials other than gelatin are made by adding an arylamino sulphonyl fluoride to a solution or suspension of the polymeric material, either in water or in an organic liquid, and which has a pH above 7 and stirring or agitating the mixture. Specified polymeric starting materials include carbohydrates or derivatives thereof containing free hydroxyl groups e.g. cellulose, starch, amylose and amylopectin and their derivatives, and synthetic polymers containing free hydroxyl and/or amino groups e.g. polyvinyl alcohol copolymers of vinyl alcohol with one or more ethylenically unsaturated copolymerizable monomers, e.g. vinyl acetate, polyvinylamine, polyvinylimine and polyethyleneimine. The starting material may be in the form of threads, fibres, fabric or film. Specified arylamino sulphonyl fluorides include o-, m-, and p-aminobenzene sulphonyl fluorides which may or may not be substituted in the benzene nucleus, e.g. by one ...

Substituted hydroxypropyl celluloses

A water-soluble hydroxypropyl cellulose contains an ionic substituent, the hydroxypropyl M.S. being at least 2.0 and the ionic D.S. being 0.001-0.48. The ionic substituent may be an ether, e.g. carboxylalkyl, dialkylaminoalkyl or sulphoalkyl, or an ester, e.g. a sulphate. The hydroxypropyl and ionic substituents may be introduced in either order or simultaneously. In examples, hydroxypropyl cellulose containing the following ionic substituents are prepared: carboxyl, carboxymethyl, diethylaminoethyl, carboxyethyl, a -methylcarboxymethyl, sulphoethyl, sulphopropyl, sulphate, and dimethylaminoethyl.

WAX-LIKE MATERIALS

Treatment for fabrics

ETHER-ESTER DERIVATIVES OF CELLULOSE AND THEIR APPLICATION

POLYSACCHARIDE WITH ALKENE ARYL OR ARALKYL HYDROPHOBEN AND LATEXZUSAMMENSETZUNGEN, THE POLYSACCHARIDE CONTAINING.

TEXTILE DETERGENT

THERMOPLASTIC BIOLOGICAL DEGRADABLE ONES POLYSACCHARIDDERIVATE, PROCEDURE FOR YOUR PRODUCTION AND YOUR USE

PROCEDURE FOR THE PRODUCTION OF CELLULOSE DERIVATIVES

Cellulose and acrylic based polymers and the use thereof for the treatment of infectious diseases

Modified cellulose ethers

PREPARATION OF HIGHLY REACTIVE CELLULOSE

MODIFIED POLYMERS

CELLULOSE-BASED NANOPARTICLES FOR DRUG DELIVERY

In one aspect, there is provided a compound comprising an acetylated carboxymethylcellulose (CMC- Ac) covalently linked to: at least one poly(ethylene glycol) (PEG), and at least one hydrophobic drug. In another aspect, a self-assembling nanoparticle composition comprising such compounds is provided.

POLYSACCHARIDES WITH ALKYL-ARYL AROMATIC HYDROPHOBES AND LATEX COMPOSITIONS CONTAINING SAME

Polysaccharides, including hydroxyethyl cellulose, having alkyl-aryl hydrophobic substitution, provide latex compositions, such as paints, with improved rheology and stability. Improved processes for producing such polysaccharides are also provided.

Verfahren zur Darstellung eines Polyschwefelsäureesters des Cellulose-äthansulfonsäureäthers.

Folie auf der Grundlage von Cellulosederivaten

Verfahren zur Darstellung eines Polyschwefelsäureesters des Celluloseglykolsäureäthers.

Verfahren zur Darstellung eines Polyschwefelsäureesters des Celluloseglykolsäureäthers.

Procédé de préparation d'un carbonate de cellulose

Mischung zur Herstellung von Überzügen und Verfahren zur Herstellung der Mischung

CELLULOSEAETHER ESTER, PROCEDURE FOR ITS PRODUCTION AS WELL AS ITS USE.

POLYMERE ONE WITH SUCCINYLOBERNSTEINSAEUREESTER REMAINDERS.

METHOD FOR PRODUCING HYPROMELLOSE PHTHALATE

New photosensitive polymers

Process for the preparation of organic esters of carbohydrates

Preparation of derived from cellulose

Manufactoring process of new derivatives cellulose and produced while resulting

A purification method of hydroxypropylmethyl cellulose phthalate

METHOD FOR SEPARATING AND REFINING HYDROXYPROPYLMETHYL CELLULOSE PHTHALATE

PURPOSE: Provided is a method for separating and refining hydroxypropylmethyl cellulose phthalate, which prevents particles from lumping and removes phthalic anhydride, phthalic acid, and an acetic acid solvent effectively. CONSTITUTION: The method comprises the steps of: adding 2-4pts.wt.(based on hydroxypropylmethyl cellulose of 1pts.wt.) of a fluidizing solvent selected from water or C1-C5 low alcohol to a produced mixture of the hydroxypropylmethyl cellulose phthalate obtained by reacting the hydroxypropylmethyl cellulose, alkali acetate, phthalic anhydride, alkali chlorate in the acetic acid solvent; injecting the resultant into 10-20pts.wt. of water through a spray nozzle with an air or nitrogen press velocity of 3-8l/min; stirring, filtering, and drying. The refined hydroxypropylmethyl cellulose phthalate has a particle size of 50-300mesh(300-50um). © KIPO 2003 ...

HYDROXYPROPYL METHYL CELLULOSE ACETATE SUCCINATE WITH ENHANCED ACETATE AND SUCCINATE SUBSTITUTION

Disclosed are polymers of hydroxypropyl methyl cellulose acetate succinate (HPMCAS) with unique degrees of substitution of hydroxypropoxy, methoxy, acetyl, and succinoyl groups. When used in making compositions comprising a low- solubility active agent and such polymers, the polymers provide increased aqueous concentrations and/or improved physical stability of the active agent.

METHYL CELLULOSE-BORON ALKOXIDE COMPOUNDS

This invention relates to a method for preparing carbohydrate-boron alkoxide compounds. Under anhydrous conditions, stable compounds of methyl- alpha -D-glucoside, methyl- alpha -mannoside, sucrose, cellobiose, methyl cellulose, and cellulose and boron alkoxides, such as boron ethoxide, boron prepoxide, and boron isopropoxide, were prepared in neat boron alkoxide, the parent alcohol, benzene, pyridine, and/or ethylenediamine. The method of this invention has as its objective increasing the reactivity of carbohydrates, as their molecular weights increase, with boron alkoxides by treatment in solutions of strong bases, such as pyridine and ethylenediamine. Formation of carbohydrate-boron alkoxide compounds modifies the rate of oxidation of carbohydrates and is related to preparing flame-resistant products.

Formazan compounds and method of dyeing therewith

PCT No. PCT/JP98/00748 Sec. 371 Date Aug. 9, 1999 Sec. 102(e) Date Aug. 9, 1999 PCT Filed Feb. 25, 1998 PCT Pub. No. WO98/38252 PCT Pub. Date Sep. 3, 1998For dyeing (printing, for example) cellulose fibers with a reactive dye, a blue compound is greatly desired, the blue compound being capable of generating a product dyed in blue at excellent dyeing reproducibility and with good light fastness and superior fastness against chlorine water, involving less staining of white area. The invention relates to a formazan compound in a free acid form as represented by the following formula I, a dyeing method of cellulose fibers using the same and a final dyed product prepared by the method, characterized in that the compound, the method and the product are suitable so as to overcome the problem. Formula I (wherein R represents hydrogen, sulfo group, hydroxyl group, halogen, a C1-C4 alkyl group, a C1-C4 alkoxyl group or carboxyl group; and M represents copper or nickel.

LOW MOLECULAR WEIGHT CELLULOSE MIXED ESTERS AND THEIR USE AS LOW VISCOSITY BINDERS AND MODIFIERS IN COATING COMPOSITIONS

Cellulose mixed esters are disclosed having low molecular weights and low degrees of polymerization. These new cellulose mixed esters include cellulose acetate propionate and cellulose acetate butyrate. The esters exhibit solubility in a wide range of organic solvents with minimal viscosity increase, are compatible with a wide variety of resins, and are useful in coatings and inks compositions as binder resins and rheology modifiers.

Hair Fixatives Including Cellulose Ether Based Polyglucose Polymers

A hair fixative composition includes at least one carboxylated cellulose ether based polyglucose polymer, an alcohol based solvent system, and a cosmetically acceptable additive, wherein the polyglucose polymer is soluble in the alcohol based solvent system. The polyglucose polymer is obtained by reacting at least one cellulose ether with at least one anhydride.

Hypromellose acetate succinate powder excellent in dissolved state and production method thereof, and production methods for composition for solid dispersion, coating composition, drug-containing particle, and solid preparation

Provided are HPMCAS powder having high solubility when dissolved in a solvent and being capable of suppressing generation of undissolved materials; and a method for producing the powder. More specifically, provided is hypromellose acetate succinate powder having an average ratio of L to D of from 2.0 to 3.0, wherein L and D mean maximum and minimum diameters of each particle, respectively. Also provided is a method for producing a hypromellose acetate succinate, comprising the steps of: dissolving hypromellose powder in a solvent, esterifying the dissolved hypromellose with succinic anhydride and acetic anhydride in the presence of a catalyst to obtain a reaction mixture, and mixing the reaction mixture with water to precipitate hypromellose acetate succinate, wherein the reaction mixture just before being mixed with the water has a viscosity of from 100 to 200 Pa·s.

СПОСОБЫ И КОМПОЗИЦИИ ДЛЯ РЕГУЛИРОВАНИЯ ВЕСА И ДЛЯ УЛУЧШЕНИЯ ГЛИКЕМИЧЕСКОГО КОНТРОЛЯ

... 1. Модифицированный пищевой продукт или продукт питания, содержащий пригодный в пищу полимерный гидрогель.2. Модифицированный пищевой продукт или продукт питания по п.1, отличающийся тем, что указанный пригодный в пищу полимерный гидрогель имеет коэффициент набухания 40 или больше.3. Модифицированный пищевой продукт или продукт питания по п.1, отличающийся тем, что указанный пригодный в пищу полимерный гидрогель имеет коэффициент набухания 80 или больше.4. Модифицированный пищевой продукт или продукт питания по п.1, отличающийся тем, что указанный пригодный в пищу полимерный гидрогель имеет модуль упругости не менее 200 Па.5. Модифицированный пищевой продукт или продукт питания по п.1, отличающийся тем, что указанный пригодный в пищу полимерный гидрогель имеет вязкость не менее 15 s.6. Модифицированный пищевой продукт или продукт питания по п.1, отличающийся тем, что пищевой продукт или продукт питания содержит углеводы, а указанный пригодный в пищу полимерный гидрогель заменяет по крайней ...

CARBOXYALKYLIERTE CELLULOSEESTERN

Bindemittelzusammensetzung bzw. Trägerzusammensetzung

Maleinsäureadditionsproduktgruppen enthaltende, thermoplastische und biologisch abbaubare Polysaccharidester/-etherester

PHARMAZEUTISCHE ZUSAMMENSETZUNGEN MIT VERBESSERTER LEISTUNG ENTHALTEND EIN HPMCA POLYMER

Improvements in or relating to cellulose derivative and process of preparation

Crude hydroxyethyl cellulose, containing not more than 1.4 hydroxyethyl groups per anhydroglucose unit, is washed with a non-alkaline aqueous medium, containing at least 20 per cent. by weight of water, to an ash content of less than 0.2 per cent. by weight, the water is then displaced by an inert, volatile, water-miscible, organic solvent containing not more than 15 per cent. by weight of water, the organic solvent is then removed and the product is acetylated to give a relatively undergraded hydroxyethyl cellulose acetate. The washing medium may be pure water or a mixture containing at least 20 per cent. of water with a water-miscible organic compound, such as methyl, ethyl, propyl or isopropyl alcohol, acetone, dioxane, or formic, acetic, propionic or oxalic acid. The displacing organic solvent may be anhydrous methanol, ethanol, propanol, isopropanol, acetone or dioxane, and mixtures of these with up to 15 per cent. of water, such as the azeotropic mixtures of ethyl alcohol and water ...

WAX-LIKE MATERIALS

PROCEDURE FOR THE CLEANING OF HYDROXYPROPYLMETHYLCELLULOSEPHTHALAT

ALKENYL OR ALKYL SUCCINIC ACID ESTER ABSTENTION WASSERLOESLICHE OF CELLULOSEETHER.

Biodegradable cellulose ether esters with little water absorption, a method for producing same and the use thereof

MODIFIED CELLULOSE ETHERS

The invention relates to a cellulose ether that is hydrophobically modified with an alkyl or alkenylketene dimer of general formula (I), in which R1 and R2 are alkyl or alkenyl chain, such as one having 5 to 22, preferably 13 to 20, most preferably 14 to 18 carbons. The product can be used in water-based products to control the rheological properties, for example. Objects of use include, for example, detergents, paper coating mixtures, paints, dispersing agents, and oil drilling muds.

Process for the preparation of derived from natural and synthetic polymers

Method of preparation of cellulose ether nitrates

Stabilization of Cellulose Derivatives

NOVEL HYDROXYALKYL METHYL CELLULOSE ACETATE SUCCINATES

a) 4.0 내지 10.0중량% 미만의 석시노일 그룹을 가지며, b) 80,000달톤 내지 350,000달톤의 중량 평균 분자량 M w 를 가지며, c) 아세톤 중의 1.5중량% 용액으로서 41NTU 이하의 탁도를 나타내는 신규한 하이드록시알킬 메틸 셀룰로즈 아세테이트 석시네이트; 및 a) 10.0 내지 20.0중량%의 석시노일 그룹을 가지며, b) 80,000달톤 내지 350,000달톤의 중량 평균 분자량 M w 를 가지며, c) 아세톤 중의 1.5중량% 용액으로서 37NTU 이하의 탁도를 나타내는 신규한 하이드록시알킬 메틸 셀룰로즈 아세테이트 석시네이들은, 이들 하이드록시알킬 메틸 셀룰로즈 아세테이트 석시네이트 내의 활성 성분의 고체 분산물을 제조하는데 유용하다. a) a new hide having a succinoyl group of less than 4.0 to 10.0% by weight, b) a weight average molecular weight M w of 80,000 Daltons to 350,000 Daltons, and c) a 1.5% by weight solution in acetone showing a turbidity of 41 NTU or less Hydroxyalkyl methyl cellulose acetate succinate; And a) 10.0 to 20.0 wt% succinoyl group, b) 80,000 daltons to 350,000 daltons, having a weight average molecular weight M w , c) a 1.5% by weight solution in acetone, a new hide exhibiting a turbidity of 37 NTU or less Roxyalkyl methyl cellulose acetate succinates are useful for preparing solid dispersions of the active ingredients in these hydroxyalkyl methyl cellulose acetate succinates.

디카복실산으로 에스테르화된 셀룰로스 에테르

... 하기 화학식의 그룹을 포함하는 에스테르화된 셀룰로스 에테르는, 수성 액체 중의 난용성의 약물 농도를 과포화 수준으로 유지하기 위한 부형제로서 유용하다. 상기 화학식에서, R' 및 R"는 수소 또는 (여기서, R1은 1 내지 4개의 탄소 원자를 갖는 탄화수소 그룹이고, R2는 임의로 치환된 5원 또는 6원의 사이클릭 그룹이고, m 및 n은 각각 독립적으로, 0 또는 1이다)이고, A는 수소 또는 양이온이고, 단, 각각의 그룹 에서, R' 및 R" 중 하나는 수소이고, 나머지 하나는 이다.

체중 관리 및 혈당 조절 개선을 위한 방법 및 조성물

... 본 발명은 체중 관리 및 혈당 조절에 유용한 방법, 조성물 및 변형된 식품 또는 식품재료를 제공한다.

CELLULOSE DERIVATIVE, RESIN COMPOSITION, MOLDED ARTICLE AND PROCESS FOR PRODUCTION THEREOF, AND HOUSING FOR ELECTRIC/ELECTRONIC DEVICES

Provided are a cellulose derivative and a resin composition, both of which have good thermoplasticity, strength, moldability, toughness and rigidity and are suitable for molding processing. A cellulose derivative having: A) a hydrocarbon group: -R1 (wherein R1 represents a methyl group); B) a hydrocarbon group: -R2 (wherein R2 represents a hydrocarbon group having 2-8 carbon atoms); C) a group containing both an acyl group: -CO-R3 and an alkyleneoxy group: -R4-O- (wherein R3 represents a hydrocarbon group; and R4 represents a hydrocarbon group having 2-4 carbon atoms); and D) an acyl group: -CO-R5 (wherein R5 represents a hydrocarbon group).

ACETYLATED CELLULOSE ETHER, METHOD FOR PREPARING SAME, AND ARTICLE COMPRISING THE ACETYLATED CELLULOSE ETHER

Disclosed are an acetylated cellulose ether, a method for preparing same, and an article comprising same. The disclosed acetylated cellulose ether has a degree of substitution (DS) by an alkyl group of 1-2, a degree of molar substitution (MS) by a hydroxyl alkyl group of 0-1, a degree of substitution (DS) by an acetyl group of 1-2; and an apparent density of 0.1-0.4.

Carboxyalkyl cellulose esters

This invention provides certain carboxymethyl cellulose (CMC) esters of higher acids (e.g., CMC acetate propionate, CMC propionate, CMC acetate butyrate, and CMC butyrate). These new ether derivatives of cellulose esters exhibit solubility in a wide range of organic solvents, compatibility with a variety of resins, and ease of dispersion in a water-borne formulation and are useful in coating compositions as binder resins and theology modifiers.

HYDROXYPROPYL METHYL CELLULOSE PHTHALATE AND METHOD FOR PRODUCING THE SAME

There is provided a method for producing hydroxypropyl methyl cellulose phthalate (HPMCP), including an esterification step of reacting hydroxypropyl methyl cellulose with a carboxybenzoylating agent in the presence of an aliphatic carboxylic acid in a kneader reactor equipped with two or more stirring blades rotating around their own axes and orbitally revolving, to obtain a reaction product solution containing HPMCP; a precipitation step of precipitating the HPMCP by mixing the reaction product solution with water to obtain a suspension of the precipitated HPMCP; and a washing and recovery step of washing the HPMCP in the suspension and recovering the washed HPMCP. Further, there is provided HPMCP having yellowness at 20° C. of 10.0 or less, as determined in a 10% by mass solution of the HPMCP in acetone.

Modified cellulose for biocompatible dialysis membranes III and process for preparation thereof

A modified cellulose for biocompatible dialysis membranes having a structure represented by the formula см. иллюстрацию в PDF-документе wherein cell is cellulose or chitin, in each case without hydroxyl groups, s=3 in the case of cellulose and s=2 in the case of chitin, R' is CH3 and/or C2 H5 and/or C3 H7, X denotes specified functional groups, R" is H or R, R"' denotes R, x+t=0.75 to 2.85, t=0 to 2.85, x=0 to 2.85, and r=0 to 1. A process for preparation of the cellulose derivatives is also disclosed.

Composition for hot-melt extrusion and method for producing hot-melt extrusion product using same

Provided are a composition for hot-melt extrusion which can be hot-melt extruded at a temperature lower than a conventional temperature and therefore free of heat-induced deactivation of a drug; and a method for producing a hot-melt extrusion product which is simpler than a spray-drying method. More specifically, provided is a composition for hot-melt extrusion including a drug and hypromellose acetate succinate (HPMCAS) having a hydroxypropoxy molar substitution of 0.40 or more. Also provided is a method for producing a hot-melt extrusion product including a step of hot-melt extruding a composition for hot-melt extrusion including a drug and hypromellose acetate succinate having a hydroxypropoxy molar substitution of 0.40 or more at a hot-melt temperature of melting temperature of the hypromellose acetate succinate or higher, or at a hot-melt temperature equal to or higher than a temperature at which both the hypromellose acetate succinate and the drug become melted.

Polysaccharides with alkyl-aryl hydrophobes and latex compositions containing same

Polysaccharides, including hydroxyethyl cellulose, having alkyl-aryl hydrophobic substitution, provide latex compositions, such as paints, with improved rheology and stability. Improved processes for producing such polysaccharides are also provided.

Alkyl-aralkyl-cellulose esters and process of making them

Modified cellulose for biocompatible dialysis membranes III and process for preparation thereof

A modified cellulose for biocompatible dialysis membranes having a structure represented by the formula wherein cell is cellulose or chitin, in each case without hydroxyl groups, s=3 in the case of cellulose and s=2 in the case of chitin, R' is CH3 and/or C2H5 and/or C3H7, X denotes specified functional groups, R'' is H or R, R''' denotes R, x+t=0.75 to 2.85, t=0 to 2.85, x=0 to 2.85, and r=0 to 1. A process for preparation of the cellulose derivatives is also disclosed.

Polysaccharide derivative, and preparation process and use thereof

Disclosed herein are a polysaccharide derivative obtainable by substituting a part or the whole of hydrogen atoms of hydroxyl groups in a polysaccharide or a derivative thereof by the following substituents (A) and (B): (A) a hydrophobic group containing a C10-C40 alkyl, alkenyl or acyl group which may be substituted by an -OH group or into which an oxycarbonyl group (-COO- or -OCO-) may be introduced; and (B) a C1-C5 sulfoalkyl group which may be substituted by an -OH group, or a salt thereof, wherein average degrees of substitution by the substituents (A) and (B) per monosaccharide residue are 0.001-1.0 and 0.01-2.0, respectively; a preparation process thereof; and use of the polysaccharide derivative for a thickener for cosmetic compositions.

Resinous derivatives from cellulose and other substances and alcohols

LOW-MOLECULAR WEIGHT CELLULOSE-MIXED ESTERS AND THEIR USE AS LOW VISCOSITY BINDERS AND MODIFIERS IN COATING COMPOSITIONS

PROBLEM TO BE SOLVED: To provide low-molecular weight cellulose-mixed esters that has low degree of polymerization and are useful in coating and ink compositions as low viscosity binder resins and rheology modifiers. SOLUTION: This invention relates to cellulose-mixed esters having a total degree of substitution per anhydroglucose unit of from about 3.08 to about 3.50, and having the following substitutions: a degree of substitution per anhydroglucose unit of hydroxyl of no more than about 0.70; a degree of substitution per anhydroglucose unit of C3-C4 esters from about 0.80 to about 1.40, and a degree of substitution per anhydroglucose unit of acetyl of from about 1.20 to about 2.34. The mixed esters exhibit an inherent viscosity from about 0.05 to about 0.12 dL/g, as measured in a 60/40 (wt./wt.) solution of phenol/tetrachloroethane at 25[deg.] °C; a number average molecular weight (Mn) of from about 1,000 to about 5,600; a weight average molecular weight (Mw) of from about 1,500 to about ...

Verfahren zur Herstellung von Ammoniumgruppen enthaltenden Polymeren

Verfahren zur Gewinnung von Rescidin aus Pflanzen der Rauwolfiaarten und zur Herstellung von dessen Salzen

Verfahren zur Herstellung eines biologisch abbaubaren cellulosischen Faserverbundwerkstoffs

STABILISIERTE, STICKSTOFFHALTIGE CELLULOSEDERIVATE

Process for manufacture of phosphate esters of hydroxyl-containing polymeric materials

Polymeric materials containing secondary hydroxyl groups are treated in suspension in a liquid non-aqueous organic suspension medium at a raised temperature with a substantially anhydrous reaction product of orthophosphoric acid and urea or an N-substituted urea so that at least a fraction of said hydroxyl groups are esterified to form an acid ammonium salt of formula where R and R1 represent the remainder of the polymeric molecule. Specified polymeric materials are polyvinyl alcohol and partial esters, acetals and ketals thereof; copolymers of vinyl alcohol and acrylic, methacrylic, crotonic or maleic acid or derivatives thereof; copolymers of vinyl alcohol with ethylene or vinyl chloride; cellulose derivatives such as methyl-, ethyl- and hydroxy-ethyl cellulose; and starches and fractions thereof such as amylose and amylopectin. Specified substituted ureas are methyl-, ethyl-, dimethyl- and phenyl-urea. The suspension medium may be an alcohol and/or aromatic hydrocarbon ...

Process for saponifying and alkylating shaped materials made from cellulose esters or artificial resins

Shaped materials of cellulose esters or highly polymeric artificial resins containing saponifiable groups, are subjected to treatment with an alkylene oxide or analogue thereof in the presence of a substance of alkaline reaction, the conditions of treatment being such that the materials retain their structure. The materials undergo alkylation and saponification during the treatment. Ethylene oxide, propylene, butylene cyclohexene, phenoxypropene, and morpholino propene oxide or butadiene dioxide, epichlorhydrin, propylene sulphide, ethylene imine, butylethylene imine, or cyclohexyl ethylene imine, are specified alkylene oxides or analogues. The materials treated may be in the form of suspensions of flocks or fibres, including cotton linters acetylated with retention of the fibrous structure, threads, bristles, sheets, films, spun goods, or fabrics. Materials of cellulose acetate, formate, acetate-formate, or other mixed ester or ether-ester of cellulose, or polyvinyl esters, poly-acid esters ...

WATER-SOLUBLE, FLOCK-CASH AND BIOLOGICAL DEGRADABLE HYDROXYALKYLCELLULOSE-2 HYDROXY ACID ESTER

BIOCOMPATIBLE HEMODIALYSIS DIAPHRAGMS FROM MODIFIED CELLULOSE

PHARMACEUTICAL COMPOSITIONS WITH IMPROVED ACHIEVEMENT CONTAINING A HPMCA POLYMER

MODIFIED CELLULOSEETHER

Methods and compositions for weight management and for improving glycemic control

The present invention provides methods, compositions and modified foods and foodstuffs useful for weight management and glycemic control.

CARBOXYMETHYL HYDROPHOBICALLY MODIFIED HYDROXYETHYL CELLULOSE AND ITS USE IN PROTECTIVE COATING COMPOSITIONS

CARBOXYMETHYL HYDROPHOBICALLY MODIFIED HYDROXYETHYL CELLULOSE AND ITS USE IN PROTECTIVE COATING COMPOSITIONS

CELLULOSE AND ACRYLIC BASED POLYMERS AND THE USE THEREOF FOR THE TREATMENT OF INFECTIOUS DISEASES

ALKYLENE OXIDE MODIFIED HARDWOOD CELLULOSE

Disclosed is a process for producing reactive cellulose for use in the manufacture of cellulose acetate having superior clarity by mercerizing hardwood cellulosic material and reacting it with an hydroxyalkylating agent to a degree of molar substitution ranging from 0.04 to 0.15 per anhydroglucose unit in cellulose.

EFFECT LACQUER AND LACQUERING, IN PARTICULAR FOR CAR BODIES, INVOLVING THE USE OF LIQUID CRYSTAL INTERFERENCE PIGMENTS

The invention relates to interference pigments for effect finishes, to effect paints produced therewith, and to commodity articles, especially vehicle bodies, painted with these paints. In order to make it possible to prepare chiral nematic polymers for such effect paints more simply, i.e. in fewer synthesis steps, with, moreover, only a readily available component of favourable cost being required, the interference pigments consist in accordance with the invention of esterified cellulose ethers. With these interference pigments it is possible to produce, in the coating, an alternation of colour which is dependent on the direction of incidence of light and on the direction of viewing, or particularly intense shades of previously unknown brightness, on the article painted therewith.

Improvements in the manufacture of the cellulose derivatives

Method of preparation of derived from cellulose

Manufactoring process of soluble oxalcoyle-cellulose esters of organic acids

Method of preparation of esters of cellulose

Polysaccharide, neutralized and polysaccharide composition containing same

Polysaccharide. il a des groupes hydrophile fonctionnels et des groupes nitrate de la manière suivante: (CF DESSIN DANS BOPI) X et Y représentant le nombre de groupes hydroxyle fonctionnels et de groupes nitrate par motif répétitif du polysaccharide respectivement. Industrie du papier.

CELLULOSE CARBONATES AND METHOD FOR THEIR PREPARATION

EFFECT LACQUER AND LACQUERING, IN PARTICULAR FOR CAR BODIES INVOLVING THE USE OF LIQUID CRYSTAL INTERFERENCE PIGMENTS

가열 용융 압출용 조성물 및 이를 이용한 가열 용융 압출 성형물의 제조 방법

종래보다도 낮은 온도에서 가열 용융 압출함으로써, 열 등에 의한 약물의 실활이 없는, 가열 용융 압출 조성물 및 스프레이 드라이법보다도 간편한 방법에 의해 가열 용융 압출 성형물이 얻어지는 가열 용융 압출 성형물의 제조 방법을 제공한다. 구체적으로는 히드록시프로폭시기의 몰 치환도가 0.40 이상인 히프로멜로오스아세트산에스테르숙신산에스테르(HPMCAS)와 약물을 적어도 포함하는 가열 용융 압출용 조성물을 제공한다. 또한, 히드록시프로폭시기의 몰 치환도가 0.40 이상인 히프로멜로오스아세트산에스테르숙신산에스테르와 약물을 적어도 포함하는 가열 용융 압출용 조성물을 히프로멜로오스아세트산에스테르숙신산에스테르의 용융 온도 이상, 또는 히프로멜로오스아세트산에스테르숙신산에스테르 및 약물과 함께 용융하게 되는 온도 이상의 가열 용융 온도에서 가열 용융하고, 압출하는 공정을 적어도 포함하는 가열 용융 압출 성형물의 제조 방법을 제공한다. The present invention provides a method for producing a hot-melt extruded product in which a heated melt-extruded product is obtained by a method that is simpler than a heated melt-extruded composition and a spray-dry method without thermal deformation of the drug by heating and melt- Specifically, there is provided a composition for hot melt extrusion comprising at least a hydromoroxacetic ester succinic acid ester (HPMCAS) having a molar substitution degree of a hydroxypropoxy group of 0.40 or more and a drug. The composition for hot melt extrusion containing at least a hydromoroxacetic ester succinic acid ester having a molar substitution degree of the hydroxypropoxy group of not less than 0.40 and a drug is heated at a temperature not lower than the melting temperature of the hydromelose acetic acid ester succinic acid ester, Meloxacetate ester succinic ester and meloxic acid ester succinic acid ester together with the drug at a heating and melting temperature equal to or higher than a temperature at which the meloxic acid ester succinic acid ester and the drug are melted together, and extruding the melted extrudate.

NOVEL ESTERIFIED CELLULOSE ETHERS OF LOW VISCOSITY

(i) 지방족 1가 아실 그룹 또는 (ii) R이 2가 지방족 또는 방향족 탄화수소 그룹이고, A가 수소 또는 양이온인 화학식 -C(O)-R-COOA의 그룹, 또는 (iii) 지방족 1가 아실 그룹과 화학식 -C(O)-R-COOA의 그룹의 조합을 포함하고, 20℃에서 0.43중량% 수성 NaOH 중의 상기 에스테르화된 셀룰로스 에테르의 2.0중량% 용액으로서 측정 시, 2.33mPaㆍs 이하의 점도 및 20℃에서 아세톤 중의 상기 에스테르화된 셀룰로스 에테르의 10중량% 용액으로서 측정 시, 13mPaㆍs 이하의 점도를 갖는, 에스테르화된 셀룰로스 에테르가 약물을 포함하는 고체 분산물의 제조에 유용하다. (i) an aliphatic monovalent acyl group or (ii) a group of the formula -C (O) -R-COOA where R is a divalent aliphatic or aromatic hydrocarbon group, and A is hydrogen or cation, or (iii) an aliphatic monovalent acyl A combination of a group and a group of the formula -C (O) -R-COOA, measured as a 2.0% by weight solution of the esterified cellulose ether in 0.43% by weight aqueous NaOH at 20 ° C, not more than 2.33mPa · s Esterified cellulose ethers having a viscosity of 13 mPa · s or less, as measured as a 10% by weight solution of the esterified cellulose ether in acetone at a viscosity and 20 ° C., are useful for the preparation of solid dispersions containing the drug.

PROCESS OF PREPARING AN ESTERIFIED CELLULOSE ETHER IN THE PRESENCE OF AN ALKALI METAL CARBOXYLATE AND AN ALIPHATIC CARBOXYLIC ACID

A PROCEDURE TO PRODUCE SULPHATE OF ALKALINE CELLULOSE ETHER

CELLULOSAETRAR.

Water-soluble polysaccharide ethers and their use

The invention relates to modified polysaccharide ethers having a weight-averaged molecular weight of 40000 to 50000 g/mole, zero shear viscosity of more than 10 Pas, and pseudoplasticity of more than 20, obtainable by reacting cellulose-based polysaccharide ether(s) with at least one mesogenic modification agent or modified polysaccharide ethers, obtainable by reacting polysaccharide ether(s) selected from the group consisting of hydroxypropylmethyl cellulose (HPMC), hydroxyethylmethyl cellulose (HEMC), methyl cellulose, and cellulose ethers with methyl and/or ethyl and/or propyl groups and mixtures thereof, with at least one mesogenic modification agent. Said substances can be used to produce gel-like to stable aqueous preparations having viscoelastic flow properties, which are suited for use in the human body, particularly within the scope of ophthalmologic procedures.

Acetylated cellulose ether and articles comprising the same

Acetylated cellulose ether and an article including the same. The acetylated cellulose ether has a degree of substitution (DS) of alkyl group of 1 to 2, a molar substitution (MS) of hydroxyalkyl group of 0 to 1, and a degree of substitution (DS) of acetyl group of 1 to 2.

ACETYLATED CELLULOSE ETHER AND ARTICLES INCLUDING SAME

Provided are acetylated cellulose ether and an article including the same. The acetylated cellulose ether has a molecular weight of about 1,000 to about 1,000,000 Daltons, a contact angle of about 20 to about 45 degrees (°), and a tensile strength of about 50 to about 100 MPa. 1. Acetylated cellulose ether having a molecular weight of about 1 ,000 to about 1 ,000 ,000Daltons , a contact angle of about 20 to about 45 degrees(°) , and a tensile strength of about 50 to about 100 MPa.2. The acetylated cellulose ether according to claim 1 , wherein the acetylated cellulose ether has a degree of substitution (DS) of an alkyl group of 1 to 2 claim 1 , a molar substitution (MS) of a hydroxyalkyl group of 0 to 1 claim 1 , and a DS of an acetyl group of 1 to 2.3. The acetylated cellulose ether according to claim 1 , wherein the acetylated cellulose ether is formed by acetylation of at least one cellulose ether selected from the group consisting of methyl cellulose claim 1 , hydroxypropyl methyl cellulose claim 1 , and hydroxy ethyl methylcellulose.4. An article including the acetylated cellulose ether according to .5. The article according to claim 4 , wherein the article is a membrane for water treatment.6. An article including the acetylated cellulose ether according to .7. An article including the acetylated cellulose ether according to .8. The article according to claim 6 , wherein the article is a membrane for water treatment.9. The article according to claim 7 , wherein the article is a membrane for water treatment. The present disclosure relates to acetylated cellulose ether and an article including the same, and more particularly, to acetylated cellulose ether having a molecular weight of about 1,000 to about 1,000,000 Daltons, a contact angle of about 20 to about 45 degrees(°), and a tensile strength of about 50 to about 100 MPa.A material for a membrane for water treatment should have a high hydrophilicity, chlorine resistance, and tensile strength. More ...

ESTERIFIED CELLULOSE ETHERS COMPRISING PHTHALYL GROUPS

An esterified cellulose ether is provided wherein the ester groups are phthalyl groups, the degree of substitution of phthalyl groups is from 0.02 to 0.18, the degree of neutralization of phthalyl groups is not more than 0.75, and the esterified cellulose ether has a solubility in water of at least 2.0 weight percent at 2° C. 1. A hydroxypropyl methyl cellulose phthalate , wherein{'sub': 6', '4', '6', '4', '6', '4, 'sup': −', '−, 'the degree of substitution of phthalyl groups is from 0.02 to 0.18, the degree of neutralization of phthalyl groups is not more than 0.75, wherein the degree of neutralization=[—C(O)—CH—COO]/[—C(O)—CH—COO+—C(O)—CH—COOH], and'}the hydroxypropyl methyl cellulose phthalate has a solubility in water of at least 2.0 weight percent at 2° C.2. The hydroxypropyl methyl cellulose phthalate of wherein the degree of substitution of phthalyl groups is from 0.05 to 0.17.3. The hydroxypropyl methyl cellulose phthalate of wherein the degree of neutralization of phthalyl groups is not more than 0.6.4. The hydroxypropyl methyl cellulose phthalate of wherein at least 85 wt % of the hydroxypropyl methyl cellulose phthalate is soluble in a mixture of 2.5 weight parts of the hydroxypropyl methyl cellulose phthalate and 97.5 weight parts of water at 2° C.5. A liquid composition comprising the hydroxypropyl methyl cellulose phthalate of dissolved in an aqueous liquid.6. The liquid composition of having a temperature of 15° C. or less.7. A liquid composition comprising at least one hydroxypropyl methyl cellulose phthalate of and an organic diluent.8. A process for coating a dosage form comprising the step of contacting the liquid composition of with the dosage form.9. A process for the manufacture of capsule shells comprising the step of contacting the liquid composition of with dipping pins.10. A coated dosage form wherein the coating comprises at least one hydroxypropyl methyl cellulose phthalate of .11. A polymeric capsule shell comprising at least one ...

HYPROMELLOSE ACETATE SUCCINATE POWDER EXCELLENT IN DISSOLVED STATE AND PRODUCTION METHOD THEREOF, AND PRODUCTION METHODS FOR COMPOSITION FOR SOLID DISPERSION, COATING COMPOSITION, DRUG-CONTAINING PARTICLE, AND SOLID PREPARATION

Provided are HPMCAS powder having high solubility when dissolved in a solvent and being capable of suppressing generation of undissolved materials; and a method for producing the powder. More specifically, provided is hypromellose acetate succinate powder having an average ratio of L to D of from 2.0 to 3.0, wherein L and D mean maximum and minimum diameters of each particle, respectively. Also provided is a method for producing a hypromellose acetate succinate, comprising the steps of: dissolving hypromellose powder in a solvent, esterifying the dissolved hypromellose with succinic anhydride and acetic anhydride in the presence of a catalyst to obtain a reaction mixture, and mixing the reaction mixture with water to precipitate hypromellose acetate succinate, wherein the reaction mixture just before being mixed with the water has a viscosity of from 100 to 200 Pa·s. 1. A method for producing a coating composition , comprising the step of dissolving the hypromellose acetate succinate powder having an average ratio of L to D of from 2.0 to 3.0 in a solvent which is a mixed solution of water and an alcohol , or an aqueous ammonia solution ,wherein L and D mean maximum and minimum diameters of each particle, respectively.2. The method for producing a coating composition according to claim 1 ,{'sup': '2', 'wherein the hypromellose acetate succinate powder has a specific surface area of from 2.0 to 5.0 m/g or more.'}3. The method for producing a coating composition according to claim 1 ,wherein the hypromellose acetate succinate powder has a loose bulk density of from 0.10 to 0.25 g/mL.4. The method for producing a coating composition according to claim 1 ,wherein the hypromellose acetate succinate powder comprises 10% by weight or less of component not soluble at 20° C. in such a weight of acetone as to be 10 times the weight of the powder.5. A method for producing a drug-containing particle claim 1 , comprising:{'claim-ref': {'@idref': 'CLM-00001', 'claim 1'}, 'each ...

PROCESS OF PREPARING AN ESTER OF A CELLULOSE ETHER

A reaction product mixture is obtained from a reaction of (a) a cellulose ether with (b) an aliphatic monocarboxylic acid anhydride or with a di- or tricarboxylic acid anhydride or with a combination of an aliphatic mono-carboxylic acid anhydride and a di- or tri-carboxylic acid anhydride in the presence of (c) an aliphatic carboxylic acid. A process for precipitating an esterified cellulose ether from this reaction product mixture comprises the step of contacting the reaction product mixture with water and subjecting the combination of water and the reaction product mixture to a shear rate of at least 800 s. The precipitated esterified cellulose ether can be recovered as a non-tacky product. 1. A process for precipitating an esterified cellulose ether from a reaction product mixture obtained from a reaction of (a) a cellulose ether with (b) an aliphatic monocarboxylic acid anhydride or a di- or tricarboxylic acid anhydride or a combination of an aliphatic monocarboxylic acid anhydride and a di- or tricarboxylic acid anhydride in the presence of (c) an aliphatic carboxylic acid , wherein the process comprises the step of contacting the reaction product mixture with water and subjecting the combination of water and the reaction product mixture to a shear rate of at least 800 s.2. The process of wherein the reaction product mixture has been obtained from a reaction of (a) a cellulose ether with (b) an aliphatic monocarboxylic acid anhydride or a di- or tricarboxylic acid anhydride or a combination of an aliphatic monocarboxylic acid anhydride and a di- or tricarboxylic acid anhydride in the presence of a combination of (c) an aliphatic carboxylic acid and (d) an alkali metal carboxylate.3. The process of wherein the combination of water and the reaction product mixture is subjected to a shear rate of at least 1500 s.4. The process of wherein the combination of water and the reaction product mixture is subjected to a shear rate of at least 3000 s.5. The process of ...

PROCESS FOR FRACTIONATING AN ESTERIFIED CELLULOSE ETHER

A process for fractionating an esterified cellulose ether comprising groups of the formula —C(O)—R—COOH, wherein R is a divalent hydrocarbon group, comprises the steps of a) blending the esterified cellulose ether comprising groups of the formula —C(O)—R—COOH with an aqueous liquid and setting the temperature of the resulting blend to less than 10° C. to dissolve a portion of the esterified cellulose ether in the aqueous liquid, b) separating the non-dissolved portion of the esterified cellulose ether from the remainder of the blend, and c) recovering or disposing of the esterified cellulose ether that is dissolved in the aqueous liquid. 1. A process for fractionating an esterified cellulose ether comprising groups of the formula —C(O)—R—COOH , wherein R is a divalent hydrocarbon group , which process comprises the steps ofa) blending the esterified cellulose ether comprising groups of the formula —C(O)—R—COOH with an aqueous liquid and setting the temperature of the resulting blend to less than 10° C. to dissolve a portion of the esterified cellulose ether in the aqueous liquid,b) separating the non-dissolved portion of the esterified cellulose ether from the remainder of the blend, andc) recovering or disposing of the esterified cellulose ether that is dissolved in the aqueous liquid.2. A process for preparing an esterified cellulose ether comprising groups of the formula —C(O)—R—COOH , wherein R is a divalent hydrocarbon group , which process comprises the steps ofa) reacting a cellulose ether with a dicarboxylic acid anhydride or with a combination of a dicarboxylic acid anhydride and an aliphatic monocarboxylic acid anhydride in the presence of an aliphatic carboxylic acid to produce a reaction product mixture comprising an esterified cellulose ether comprising groups of the formula —C(O)—R—COOH, precipitating the esterified cellulose ether from the reaction product mixture, blending the precipitated esterified cellulose ether with an aqueous liquid and setting ...

PROCESS FOR PREPARING AN ESTERIFIED CELLULOSE ETHER IN THE PRESENCE OF AN ALIPHATIC CARBOXYLIC ACID

A process for preparing an ester of a cellulose ether comprises the steps of reacting a cellulose ether with a dicarboxylic acid anhydride or with a combination of a dicarboxylic acid anhydride and an aliphatic monocarboxylic acid anhydride, wherein the esterification is conducted i) in the absence of an esterification catalyst or in the presence of no more than 0.1 mole of an esterification catalyst per mole of anhydroglucose units of cellulose ether, and ii) in the presence of an aliphatic carboxylic acid, wherein the molar ratio [aliphatic carboxylic acid/anhydroglucose units of cellulose ether] is up to 12/1. 1. A process for preparing an ester of a cellulose ether comprising the steps of i) in the absence of an esterification catalyst or in the presence of no more than 0.1 mole of an esterification catalyst per mole of anhydroglucose units of cellulose ether, and', 'ii) in the presence of an aliphatic carboxylic acid, wherein the molar ratio [aliphatic carboxylic acid/anhydroglucose units of cellulose ether] is up to 12/1., 'reacting a cellulose ether with a dicarboxylic acid anhydride or with a combination of a dicarboxylic acid anhydride and an aliphatic monocarboxylic acid anhydride, wherein the esterification is conducted'}2. The process of wherein the molar ratio [aliphatic carboxylic acid/anhydroglucose units of cellulose ether] is from [0.7/1] to [9.0/1].3. The process of wherein the molar ratio [aliphatic carboxylic acid/anhydroglucose units of cellulose ether] is from [3.0/1] to [9.0/1].4. The process of wherein the esterification is conducted in the absence of an esterification catalyst or in the presence of no more than 0.02 mole of an esterification catalyst per mole of anhydroglucose units of cellulose ether.5. The process of wherein the esterification catalyst is an alkali metal carboxylate.6. The process of wherein the esterification is conducted in the absence of an esterification catalyst.7. The process of wherein the cellulose ether has a ...

PROCESS FOR RECOVERING AN ESTERIFIED CELLULOSE ETHER FROM A REACTION PRODUCT MIXTURE

A process for recovering an esterified cellulose ether from a reaction product mixture obtained from a reaction of (a) a cellulose ether with (b) an aliphatic monocarboxylic acid anhydride or a di- or tricarboxylic acid anhydride or a combination of an aliphatic monocarboxylic acid anhydride and a di- or tricarboxylic acid anhydride, comprises the steps of (i) contacting the reaction product mixture with an aqueous liquid and precipitating the esterified cellulose ether from the reaction product mixture, and (ii) isolating the precipitated esterified cellulose ether from the mixture obtained in step (i), Tackiness of the esterified cellulose ether can be reduced when before or in step (i) a particulate silicon oxide or metal oxide is dispersed or suspended in the reaction product mixture, the aqueous liquid or a combination thereof. 1. A process for recovering an esterified cellulose ether from a reaction product mixture obtained from a reaction of (a) a cellulose ether with (b) an aliphatic monocarboxylic acid anhydride or a di- or tricarboxylic acid anhydride or a combination of an aliphatic monocarboxylic acid anhydride and a di- or tricarboxylic acid anhydride , wherein the process comprises the steps of(i) contacting the reaction product mixture with an aqueous liquid and precipitating the esterified cellulose ether from the reaction product mixture, and(ii) isolating the precipitated esterified cellulose ether from the mixture obtained in step (i),wherein before or in step (i) a particulate silicon oxide or metal oxide is dispersed or suspended in the reaction product mixture, the aqueous liquid or a combination thereof2. The process of wherein the particulate silicon oxide or metal oxide is dispersed or suspended in the aqueous liquid before contacting the reaction product mixture with the aqueous liquid.3. The process of wherein the reaction product mixture has been obtained from a reaction of (a) a cellulose ether with (b) an aliphatic monocarboxylic acid ...

PROCESS FOR FRACTIONATING AN ESTERIFIED CELLULOSE ETHER

A process for fractionating an esterified cellulose ether comprising groups of the formula —C(O)—R—COOH, wherein R is a divalent hydrocarbon group, comprises the steps of 1. A process for fractionating an esterified cellulose ether comprising groups of the formula —C(O)—R—COOH , wherein R is a divalent hydrocarbon group , which process comprises the steps ofa) blending the esterified cellulose ether comprising groups of the formula —C(O)—R—COOH with an aqueous liquid and setting the temperature of the resulting blend to less than 10° C. to dissolve a portion of the esterified cellulose ether in the aqueous liquid,b) separating the non-dissolved portion of the esterified cellulose ether from the remainder of the blend, andc) recovering or disposing of the esterified cellulose ether that is dissolved in the aqueous liquid.2. A process for preparing an esterified cellulose ether comprising groups of the formula —C(O)—R—COOH , wherein R is a divalent hydrocarbon group , which process comprises the steps ofa) reacting a cellulose ether with a dicarboxylic acid anhydride or with a combination of a dicarboxylic acid anhydride and an aliphatic monocarboxylic acid anhydride in the presence of an aliphatic carboxylic acid to produce a reaction product mixture comprising an esterified cellulose ether comprising groups of the formula —C(O)—R—COOH, precipitating the esterified cellulose ether from the reaction product mixture, blending the precipitated esterified cellulose ether with an aqueous liquid and setting the temperature of the resulting blend to less than 10° C. to dissolve a portion of the esterified cellulose ether in the aqueous liquid,b) separating the non-dissolved portion of the esterified cellulose ether from the remainder of the blend, andc) recovering or disposing of the esterified cellulose ether that is dissolved in the aqueous liquid.3. The process of wherein step a) comprises setting the temperature of the resulting blend to a temperature of less than 8° C. ...

ESTERIFIED CELLULOSE ETHERS HAVING A SPECIFIC SUBSTITUENT DISTRIBUTION

An esterified cellulose ether comprises (i) aliphatic monovalent acyl groups or (ii) groups of the formula —C(O)—R—COOA wherein R is a divalent aliphatic or aromatic hydrocarbon group and A is hydrogen or a cation or (iii) a combination of aliphatic monovalent acyl groups and groups of the formula —C(O)—R—COOA, wherein the cellulose ether has anhydroglucose units joined by 1-4 linkages and has methyl groups, hydroxyalkyl groups, and optionally alkyl groups being different from methyl as substituents such that the esterified cellulose ether has an MS (hydroxyalkyl) of 0.05 to 1.00, and hydroxyl groups of anhydroglucose units are substituted with methyl groups such that [s23/s26−0.2*MS(hydroxyalkyl)] is 0.36 or less, wherein s23 is the molar fraction of anhydroglucose units wherein only the two hydroxyl groups in the 2- and 3-positions of the anhydroglucose unit are substituted with a methyl group and wherein s26 is the molar fraction of anhydroglucose units wherein only the two hydroxyl groups in the 2- and 6-positions of the anhydroglucose unit are substituted with a methyl group. The esterified cellulose ether is useful as an excipient for poorly water-soluble drugs. 2. The esterified cellulose ether of comprising (i) aliphatic monovalent acyl groups or (ii) groups of the formula —C(O)—R—COOH wherein R is a divalent aliphatic or aromatic hydrocarbon group or (iii) a combination of aliphatic monovalent acyl groups and groups of the formula —C(O)—R—COOH.3. The esterified cellulose ether of wherein the aliphatic monovalent acyl groups (i) are acetyl claim 2 , propionyl or butyryl groups and wherein the groups (ii) of the formula —C(O)—R—COOH are —C(O)—CH—CH—COOH claim 2 , —C(O)—CH═CH—COOH claim 2 , or —C(O)—CH—COOH.4. The esterified cellulose ether of being an esterified hydroxyalkyl methyl cellulose.5. The esterified cellulose ether of being an esterified hydroxypropyl methylcellulose and having an [s23/s26−0.2*MS(hydroxyalkyl)] of 0.31 or less.6. The esterified ...

WATER-SOLUBLE ESTERIFIED CELLULOSE ETHERS

1. An esterified cellulose ether which i) comprises groups of the formula —C(O)—R—COOH or a combination of aliphatic monovalent acyl groups and groups of the formula —C(O)—R—COOH, wherein R is a divalent hydrocarbon group, ii) has a weight average molecular weight Mof up to 70,000 Dalton, iii) has a degree of neutralization of the groups —C(O)—R—COOH of not more than 0.4, and iv) has a solubility in water of at least 2.0 weight percent at 2° C., is useful for preparing enteric capsules. 1. An esterified cellulose ether{'sub': 2', '2', '2', '2, 'i) comprising groups of the formula —C(O)—CH—CH—COOH or a combination of acetyl groups and groups of the formula —C(O)—CH—CH—COOH,'}{'sub': 'w', 'ii) having a weight average molecular weight Mof up to 70,000 Dalton,'}{'sub': 2', '2, 'iii) having a degree of neutralization of the groups —C(O)—CH—CH—COOH of not more than 0.4, and'}iv) having a solubility in water of at least 2.0 weight percent at 2° C.2. The esterified cellulose ether of having a Polydispersity Man claim 1 , of not more than 2.0.3. The esterified cellulose ether of having a viscosity of up to 13 mPa·s claim 1 , measured as a 10 wt.-% solution of the esterified cellulose ether in acetone at 20° C.4. The esterified cellulose ether of wherein at least 85 wt. % of the esterified cellulose ether is soluble in a mixture of 2.5 weight parts of the esterified cellulose ether and 97.5 weight parts of water at 2° C.5. The esterified cellulose ether of wherein at least 85 wt. % of the esterified cellulose ether is soluble in a mixture of 10 weight parts of the esterified cellulose ether and 90 weight parts of water at 2° C.6. The esterified cellulose ether of being hydroxypropyl methyl cellulose acetate succinate.7. A liquid composition comprising at least one esterified cellulose ether of dissolved in an aqueous diluent.8. A liquid composition comprising at least one esterified cellulose ether of and an organic diluent.9. The liquid composition of comprising at least 5 ...

WATER-SOLUBLE ESTERIFIED CELLULOSE ETHERS HAVING A LOW DEGREE OF NEUTRALIZATION

An esterified cellulose ether comprising aliphatic monovalent acyl groups and groups of the formula —C(O)—R—COOH, R being a divalent hydrocarbon group, has the following properties: i) the degree of neutralization of the groups —C(O)—R—COOH is not more than 0.4, ii) the total degree of ester substitution is from 0.10 to 0.70, and iii) the esterified cellulose ether has a solubility in water of at least 2.0 weight percent at 2 C. 1. An esterified cellulose ether comprising aliphatic monovalent acyl groups and groups of the formula —C(O)—R—COOH , R being a divalent hydrocarbon group , whereini) the degree of neutralization of the groups —C(O)—R—COOH is not more than 0.4,ii) the total degree of ester substitution is from 0.10 to 0.70, andiii) the esterified cellulose ether has a solubility in water of at least 2.0 weight percent at 2° C.2. The esterified cellulose ether of wherein the total degree of ester substitution is from 0.20 to 0.60.3. The esterified cellulose ether of having a degree of substitution of aliphatic monovalent acyl groups of from 0.25 to 0.69 or a degree of substitution of groups of formula —C(O)—R—COOH of from 0.05 to 0.45.4. The esterified cellulose ether of wherein the aliphatic monovalent acyl groups are acetyl claim 1 , propionyl or butyryl groups claim 1 , and the groups of the formula —C(O)—R—COOH are —C(O)—CH—CH—COOH.5. The esterified cellulose ether of wherein at least 85 wt. % of the esterified cellulose ether is soluble in a mixture of 2.5 weight parts of the esterified cellulose ether and 97.5 weight parts of water at 2° C.6. The esterified cellulose ether of wherein at least 90 wt. % of the esterified cellulose ether is soluble in a mixture of 2.5 weight parts of the esterified cellulose ether and 97.5 weight parts of water at 2° C.7. An aqueous composition comprising an esterified cellulose ether of dissolved in an aqueous liquid.8. The aqueous composition of comprising at least 10 weight percent of dissolved esterified cellulose ...

GELLING ESTERIFIED CELLULOSE ETHERS

An esterified cellulose comprising aliphatic monovalent acyl groups and groups of the formula —C(O)—R—COOH, R being a divalent hydrocarbon group, has the following properties: i) the degree of neutralization of the groups —C(O)—R—COOH is not more than 0.4, ii) the total degree of ester substitution is from 0.03 to 0.38, and iii) the esterified cellulose ether has a solubility in water of at least 2.0 weight percent at 20° C. 1. An esterified cellulose ether comprising aliphatic monovalent acyl groups and groups of the formula —C(O)—R—COOH , R being a divalent hydrocarbon group , whereini) the degree of neutralization of the groups —C(O)—R—COOH is not more than 0.4,ii) the total degree of ester substitution is from 0.03 to 0.38, andiii) the esterified cellulose ether has a solubility in water of at least 2.0 weight percent at 20° C.2. The esterified cellulose ether of wherein the total degree of ester substitution is from 0.09 to 0.27.3. The esterified cellulose ether of having a degree of substitution of aliphatic monovalent acyl groups of from 0.03 to 0.20 and a degree of substitution of groups of formula —C(O)—R—COOH of from 0.01 to 0.15.4. The esterified cellulose ether of having a weight average molecular weight Mof up to 100 claim 1 ,000 Dalton.5. The esterified cellulose ether of wherein the aliphatic monovalent acyl groups are acetyl claim 1 , propionyl or butyryl groups claim 1 , and the groups of the formula —C(O)—R—COOH are —C(O)—CH—CH—COOH.6. The esterified cellulose ether of wherein at least 85 wt. % of the esterified cellulose ether is soluble in a mixture of 2.5 weight parts of the esterified cellulose ether and 97.5 weight parts of water at 2° C.7. An aqueous composition comprising an esterified cellulose ether of dissolved in an aqueous liquid.8. The aqueous composition of comprising at least 10 weight percent of the esterified cellulose ether claim 7 , based on the total weight of the aqueous composition.9. A liquid composition comprising at least ...

Biodegradable material and method for preparing the same

A biodegradable material and a method for preparing a biodegradable material are provided. The biodegradable material includes a continuous phase and a dispersed phase. The continuous phase includes a polyester, and the dispersed phase includes a modified saccharide oligomer. In particular, the weight ratio of the modified saccharide oligomer to the polyester is from 3:97 to 30:70. The dispersed phase has a maximum diameter of 100 nm to 900 nm.

Composition for hot melt extrusion and method for producing hot melt extrudate by using same

Provided is a composition for hot melt extrusion including a drug and hypromellose acetate succinate (HPMCAS) having a hydroxypropoxy molar substitution of 0.40 or more and a mole ratio of an acetyl group to a succinyl group of less than 1.6. Further, provided is a method for producing a hot melt extrudate including the step of hot melt-extruding a composition for hot melt extrusion including a drug and hypromellose acetate succinate having a molar hydroxypropoxy substitution of 0.40 or more and a mole ratio of an acetyl group to a succinyl group of less than 1.6, at a hot melt temperature of not lower than a melting temperature of the hypromellose acetate succinate or of not lower than a temperature at which both the hypromellose acetate succinate and the drug are melted.

EFFICIENT PROCESS OF PREPARING AN ESTERIFIED CELLULOSE ETHER

An esterified cellulose ether is produced in a highly efficient manner in a process for reacting a cellulose ether with an aliphatic monocarboxylic acid anhydride and a dicarboxylic acid anhydride, wherein the process comprises the steps of a) preparing a reaction mixture comprising the cellulose ether, the aliphatic monocarboxylic acid anhydride and the aliphatic carboxylic acid such that the molar ratio of aliphatic carboxylic acid to anhydroglucose units of cellulose ether is up to 9.0:1 and heating the reaction mixture to a temperature of from 60° C. to 110° C. prior to, during or after mixing the components of the reaction mixture, and b) keeping the reaction mixture at least 15 minutes at the temperature of from 60° C. to 110° C. before adding dicarboxylic acid anhydride to the reaction mixture. 1. A process for reacting a cellulose ether with an aliphatic monocarboxylic acid anhydride and a dicarboxylic acid anhydride in the presence of an aliphatic carboxylic acid , wherein the process comprises the steps ofa) preparing a reaction mixture comprising the cellulose ether, the aliphatic monocarboxylic acid anhydride and the aliphatic carboxylic acid such that the molar ratio of aliphatic carboxylic acid to anhydroglucose units of cellulose ether is up to 9.0:1 and heating the reaction mixture to a temperature of from 60° C. to 110° C. prior to, during or after mixing the components of the reaction mixture, andb) keeping the reaction mixture at least 15 minutes at the temperature of from 60° C. to 110° C. before adding dicarboxylic acid anhydride to the reaction mixture.2. A process for producing an esterified cellulose ether having a weight average molecular weight Mof from 20 ,000 to 150 ,000 Dalton or a viscosity of up to 30 mPa·s , measured as a 10 wt.-% solution of the esterified cellulose ether in acetone at 20° C. , or both in a process for reacting a cellulose ether with an aliphatic monocarboxylic acid anhydride and a dicarboxylic acid anhydride in the ...

Process of preparing a high molecular weight esterified cellulose ether

An esterified cellulose ether of increased weight average molecular weight is produced in a process for reacting a cellulose ether with an aliphatic monocarboxylic acid anhydride and a dicarboxylic acid anhydride, wherein the process comprises the steps of a) preparing a reaction mixture comprising the cellulose ether, the dicarboxylic acid anhydride and a reaction diluent and heating the reaction mixture to a temperature of from 60 C to 110 C prior to, during or after mixing the components of the reaction mixture, and b) adding continuously or in at least three portions the monocarboxylic acid anhydride to the reaction mixture of step a) and completing the reaction.

Process for producing esterified cellulose ethers of very high molecular weight and low viscosity

A modified process for producing an esterified cellulose ether is provided which comprises the stages of i) preparing a reaction mixture comprising a cellulose ether, an aliphatic monocarboxylic acid anhydride, a dicarboxylic acid anhydride, and a reaction diluent and heating the reaction mixture to a temperature of from 60° C. to 110° C. prior to, during or after mixing the components of the reaction mixture to conduct an esterification reaction, and ii) before the esterification reaction is completed, adding an additional amount of reaction diluent continuously or in one or more portions to the reaction mixture and allowing the esterification reaction to further proceed.

HYPROMELLOSE ACETATE SUCCINATE, METHOD FOR PRODUCING THE SAME AND COMPOSITION CONTAINING THE SAME

Provided are hypromellose acetate succinate (HPMCAS) which exhibits high solubility and can suppress generation of undissolved materials when dissolved in a solvent; an HPMCAS-containing composition; and a method for producing the HPMCAS. More specifically, provided are HPMCAS having a ratio of 2-position MS to 3-position MS of 1.2 or less, wherein the 2-position MS means a molar substitution of hydroxypropyl group by which a hydrogen atom of a hydroxyl group on 2-position carbon of each glucose unit of the HPMCAS has been directly replaced, and the 3-position MS means a molar substitution of hydroxypropyl group by which a hydrogen atom of a hydroxyl group on 3-position carbon of each glucose unit of the HPMCAS has been directly replaced; a composition comprising the HPMCAS and a solvent; and the method for producing the HPMCAS. 1reacting pulp with an alkali to obtain alkali cellulose;reacting the alkali cellulose with a methyl etherifying agent and a hydroxypropyl etherifying agent to obtain hydroxypropyl methyl cellulose in such a manner that a reaction ratio of the hydroxypropyl etherifying agent is 40% or less at the time when a reaction ratio of the methyl etherifying agent is 30%, or the reaction ratio of the hydroxypropyl etherifying agent is 90% or less at the time when the reaction ratio of the methyl etherifying agent is 50%; andreacting the hydroxypropyl methyl cellulose with acetic anhydride and succinic anhydride to obtain the hypromellose acetate succinate having a ratio of 2-position MS to 3-position MS of 1.2 or less, wherein the 2-position MS means a molar substitution of hydroxypropyl group by which a hydrogen atom of a hydroxyl group on 2-position carbon of each glucose unit of the hypromellose acetate succinate has been directly replaced, and the 3-position MS means a molar substitution of hydroxypropyl group by which a hydrogen atom of a hydroxyl group on 3-position carbon of each glucose unit of the hypromellose acetate succinate has been ...

NOVEL ESTERIFIED CELLULOSE ETHERS OF VERY HIGH MOLECULAR WEIGHT

Esterified cellulose ethers which comprise (i) groups of the formula —C(O)—R—COOA or (ii) a combination of aliphatic monovalent acyl groups and groups of the formula —C(O)—R—COOA, wherein R is a divalent aliphatic or aromatic hydrocarbon group and A is hydrogen or a cation, 1. A hydroxypropyl methyl cellulose acetate succinatehaving a DS(methoxyl) of from 1.6 to 2.05,having a viscosity of up to 50 mPa·s, measured as a 10 wt. % solution of the hydroxypropyl methyl cellulose acetate succinate in acetone at 20° C., and{'sub': 'w', 'having a weight average molecular weight Mof at least 220.000 Dalton,'}wherein the hydroxypropyl methyl cellulose acetate succinate has been produced by reacting a hydroxypropyl methyl cellulose having a DS(methoxyl) of from 1.6 to 2.05 with acetic anhydride and succinic anhydride in an aliphatic carboxylic acid as a reaction diluent at a molar ratio of aliphatic carboxylic acid to succinic anhydride of up to 12/1.2. The hydroxypropyl methyl cellulose acetate succinate of having a weight average molecular weight Mof at least 250 claim 1 ,000 Dalton.3. The hydroxypropyl methyl cellulose acetate succinate of having a viscosity of up 40 mPa·s claim 1 , measured as a 10 wt. % solution of the hydroxypropyl methyl cellulose acetate succinate in acetone at 20° C.4. The hydroxypropyl methyl cellulose acetate succinate of having a DS(methoxyl) of from 1.7 to 2.05.5. A composition comprising a liquid diluent and at least one hydroxypropyl methyl cellulose acetate succinate of .6. The composition of comprising from 5 to 20 percent of at least one hydroxypropyl methyl cellulose acetate succinate claim 5 , from 65 to 94 percent of a liquid diluent claim 5 , and from 1 to 15 percent of an active ingredient claim 5 , based on the total weight of the composition.7. A solid dispersion comprising at least one active ingredient and at least one hydroxypropyl methyl cellulose acetate succinate of .8. A dosage form being coated with at least one hydroxypropyl ...

PROCESS FOR RECOVERING AN ESTERIFIED CELLULOSE ETHER FROM A REACTION PRODUCT MIXTURE

A process for recovering an esterified cellulose ether from a reaction product mixture obtained from a reaction of (a) a cellulose ether with (b) an aliphatic monocarboxylic acid anhydride or a di- or tricarboxylic acid anhydride or a combination of an aliphatic monocarboxylic acid anhydride and a di- or tricarboxylic acid anhydride, comprises the steps of (i) contacting the reaction product mixture with an aqueous liquid and precipitating the esterified cellulose ether from the reaction product mixture, and (ii) isolating the precipitated esterified cellulose ether from the mixture obtained in step (i). Tackiness of the esterified cellulose ether can be reduced when a cellulose ether is added before or in step (i) to the reaction product mixture, to the aqueous liquid or a combination thereof. 1. A process for recovering an esterified cellulose ether from a reaction product mixture obtained from a reaction of (a) a cellulose ether with (b) an aliphatic monocarboxylic acid anhydride or a di- or tricarboxylic acid anhydride or a combination of an aliphatic monocarboxylic acid anhydride and a di- or tricarboxylic acid anhydride , wherein the process comprises the steps of(i) contacting the reaction product mixture with an aqueous liquid and precipitating the esterified cellulose ether from the reaction product mixture, and(ii) isolating the precipitated esterified cellulose ether from the mixture obtained in step (i),wherein a cellulose ether is added before or in step (i) to the reaction product mixture, to the aqueous liquid or a combination thereof.2. The process of wherein in step (i)the reaction product mixture is first diluted with a first amount of aqueous liquid without precipitating the esterified cellulose ether from the reaction product mixture,the diluted reaction product mixture is then contacted with a second amount of aqueous liquid to precipitate the esterified cellulose ether from the diluted reaction product mixture, while diluting the reaction ...

Pharmaceutical Compositions With Enhanced Performance and Improved Processability

The presently disclosed and claimed inventive concept(s) relates to a polymer for enhancing drug performance and improving processability. Specifically, the polymer comprises hydroxypropyl methyl cellulose acetate succinate (HPMC-AS). On the HPMC-AS, the percentage of total succinoyl degree of substitution is less than 12% at C6-OH position and greater than 53% at C3-OH, and the percentage of total acetyl degree of substitution is greater than 32% at C6-OH position.

DISPERSION COMPRISING AN ESTERIFIED CELLULOSE ETHER

An aqueous composition useful for producing capsules shells comprises a) at least one dispersed esterified cellulose ether comprising (i) groups of the formula —C(O)—R—COOA or (ii) a combination of aliphatic monovalent acyl groups and groups of the formula —C(O)—R—COOA, wherein R is a divalent aliphatic or aromatic hydrocarbon group and A is hydrogen or a cation, and b) from 0.05 to 20 percent of at least one salt of a fatty acid, based on the weight of the dispersed esterified cellulose ether, wherein the median particle size, d50, of the dispersed esterified cellulose ether particles is up to 7 micrometers, such median particle size (d50) being the size at which 50 mass percent of the particles have a smaller equivalent diameter and 50 mass percent have a larger equivalent diameter. 1. An aqueous composition comprisinga) at least one dispersed esterified cellulose ether comprising (i) groups of the formula —C(O)—R—COOA or (ii) a combination of aliphatic monovalent acyl groups and groups of the formula —C(O)—R—COOA, wherein R is a divalent aliphatic or aromatic hydrocarbon group and A is hydrogen or a cation, andb) from 0.05 to 20 percent of at least one salt of a fatty acid, based on the weight of the dispersed esterified cellulose ether,wherein the median particle size, d50, of the dispersed esterified cellulose ether particles is up to 5 micrometers, such median particle size (d50) being the size at which 50 mass percent of the particles have a smaller equivalent diameter and 50 mass percent have a larger equivalent diameter.2. The aqueous composition of comprising from 0.5 to 10 percent of an ammonium claim 1 , alkali metal or alkaline earth metal salt of a saturated or unsaturated fatty acid claim 1 , based on the weight of the dispersed esterified cellulose ether.3. The aqueous composition of wherein the salt of a fatty acid is an ammonium claim 1 , alkali metal or alkaline earth metal salt of stearic acid or oleic acid.4. The aqueous composition of ...

NOVEL ESTERIFIED CELLULOSE ETHERS OF HIGH MOLECULAR WEIGHT AND HOMOGENEITY

A process for making esterified cellulose ethers which have 115.-. (canceled)16. A process for producing a comprising the step of reacting a cellulose ether with a combination of an aliphatic monocarboxylic acid anhydride and a dicarboxylic acid anhydride in an aliphatic carboxylic acid as a reaction diluent and in the presence of an esterification catalyst at a molar ratio [aliphatic carboxylic acid/anhydroglucose units of cellulose ether] of from [4.9/1.0] to [11.5/1.0] , a molar ratio [alkali metal carboxylate/anhydroglucose units of cellulose ether] of from [0.4/1.0] to [3.3/1.0] , a molar ratio [anhydride of aliphatic monocarboxylic acid/anhydroglucose units of cellulose ether] of from [0.9/1] to [3.0/1] and a molar ratio [anhydride of a dicarboxylic acid/anhydroglucose units of cellulose ether] of from [0.1/1] to [0.6/1] ,thereby producing an esterified cellulose ether having:i) as ester groups a combination of aliphatic monovalent acyl groups and groups of the formula—C(O)—R—COOA wherein R is a divalent aliphatic or aromatic hydrocarbon group and A is hydrogen or a cation,{'sub': 'w', 'ii) a weight average molecular weight Mof from 80,000 Dalton to 350,000 Dalton,'}{'sub': w', 'n, 'iii) a Polydispersity M/Mof from 1.5 to 3.4, and'}iv) a viscosity of up to 4.0 mPa·s, measured as a 2.0 wt % solution of the esterified cellulose ether in 0.43 wt % aqueous NaOH at 20° C. according to an Ubbelohde measurement according to DIN 51562-1:1999-01, and{'sub': w', 'n', '2', '4', '3, 'wherein Mand Mare measured by SEC-MALLS using as mobile phase a mixture of 40 parts by volume of acetonitrile and 60 parts by volume of aqueous buffer containing 50 mM NaHPOand 0.1 M NaNO.'}17. The process of claim 16 , wherein the aliphatic monovalent acyl groups are acetyl claim 16 , propionyl or butyryl groups and the groups of the formula —C(O)—R—COOA are —C(O)—CH—CH—COOA claim 16 , —C(O)—CH═CH—COOA claim 16 , or —C(O)—CH—COOA.18. The process of claim 16 , wherein the esterified cellulose ...

Hypromellose acetate succinate powder excellent in dissolved state and production method thereof, and production methods for composition for solid dispersion, coating composition, drug-containing particle, and solid preparation

Provided are HPMCAS powder having high solubility when dissolved in a solvent and being capable of suppressing generation of undissolved materials; and a method for producing the powder. More specifically, provided is hypromellose acetate succinate powder having an average ratio of L to D of from 2.0 to 3.0, wherein L and D mean maximum and minimum diameters of each particle, respectively. Also provided is a method for producing a hypromellose acetate succinate, comprising the steps of: dissolving hypromellose powder in a solvent, esterifying the dissolved hypromellose with succinic anhydride and acetic anhydride in the presence of a catalyst to obtain a reaction mixture, and mixing the reaction mixture with water to precipitate hypromellose acetate succinate, wherein the reaction mixture just before being mixed with the water has a viscosity of from 100 to 200 Pa·s.

NOVEL ESTERIFIED CELLULOSE ETHERS OF HIGH MOLECULAR WEIGHT AND HOMOGENEITY

Esterified cellulose ethers which have i) a combination of aliphatic monovalent acyl groups and groups of the formula —C(O)—R—COOA wherein R is a divalent aliphatic or aromatic hydrocarbon group and A is hydrogen or a cation, ii) a weight average molecular weight Mw of from 80,000 Dalton to 350,000 Dalton, iii) a Polydispersity Mw/Mn of from 1.3 to 4.1, and iv) a viscosity of up to 4.0 mPa s, measured as a 2.0 wt % solution of the esterified cellulose ether in 0.43 wt % aqueous NaOH at 20° C., are useful as enteric polymers for pharmaceutical dosage forms. 1. An esterified cellulose ether havingi) as ester groups aliphatic monovalent acyl groups or a combination of aliphatic monovalent acyl groups and groups of the formula—C(O)—R—COOA wherein R is a divalent aliphatic or aromatic hydrocarbon group and A is hydrogen or a cation,{'sub': 'w', 'ii) a weight average molecular weight Mof from 80,000 Dalton to 350,000 Dalton,'}{'sub': w', 'n, 'iii) a Polydispersity M/Mof from 1.3 to 4.1, and'}iv) a viscosity of up to 4.0 mPa·s, measured as a 2.0 wt % solution of the esterified cellulose ether in 0.43 wt % aqueous NaOH at 20° C. according to an Ubbelohde measurement according to DIN 51562-1:1999-01,{'sub': w', 'n', '2', '4', '3, 'wherein Mand Mare measured by SEC-MALLS using as mobile phase a mixture of 40 parts by volume of acetonitrile and 60 parts by volume of aqueous buffer containing 50 mM NaHPOand 0.1 M NaNO.'}2. The esterified cellulose ether of wherein the aliphatic monovalent acyl groups are acetyl claim 1 , propionyl or butyryl groups and the groups of the formula{'sub': 2', '2', '6', '4, '—C(O)—R—COOA are —C(O)—CH—CH—COOA, —C(O)—CH═CH—COOA, or —C(O)—CH—COOA.'}3. The esterified cellulose ether of being an esterified hydroxyalkyl methyl cellulose.4. The esterified cellulose ether of being hydroxypropyl methyl cellulose acetate succinate.5. The esterified cellulose ether of having a weight average molecular weight Mof from 110 claim 1 ,000 Dalton to 200 claim 1 ,000 ...

PROCESS FOR PREPARING AN ESTER OF A CELLULOSE ETHER IN THE PRESENCE OF AN ALKALI METAL CARBOXYLATE

Two or more esters of a cellulose ether, each having the same ether and ester substituents but different weight average molecular weights are prepared in a process which comprises the steps of esterifying a cellulose ether with (i) an aliphatic monocarboxylic acid anhydride or (ii) a dicarboxylic acid anhydride or (iii) a combination of an aliphatic monocarboxylic acid anhydride and a dicarboxylic acid anhydride in the presence of an alkali metal carboxylate in two or more separate reactions, wherein in each reaction a different molar ratio [alkali metal carboxylate/anhydroglucose units of cellulose ether] is used to produce esters of the cellulose ether of different weight average molecular weights. 1. A process for preparing two or more esters of a cellulose ether , each having the same ether and ester substituents but different weight average molecular weights comprising the steps ofesterifying a cellulose ether being a hydroxypropyl methylcellulose with succinic anhydride and acetic anhydride in the presence of an alkali metal carboxylate and in the presence of an aliphatic carboxylic acid in two or more separate reactions, whereinin each reaction a different molar ratio [alkali metal carboxylate/anhydroglucose units of cellulose ether] is used to produce esters of the cellulose ether of different weight average molecular weights, wherein in each reaction the molar ratio [alkali metal carboxylate/anhydroglucose units of cellulose ether] is at least [0.3/1.0] different from the molar ratio in the other reaction(s).2. The process of wherein the molar ratio [alkali metal carboxylate/anhydroglucose units of cellulose ether] in each reaction is from [1.5/1.0] to [5.0/1.0].3. The process of wherein the molar ratio [alkali metal carboxylate/anhydroglucose units of cellulose ether] in each reaction is from [2.7/1.0] to [4.5/1.0].4. The process of wherein in each reaction hydroxypropyl methylcellulose is reacted with succinic anhydride and acetic anhydride in about the ...

METHOD FOR PREPARING ACETYLATED CELLULOSE ETHERS HAVING IMPROVED ANTI-FOULING PROPERTIES, AND ACETYLATED CELLULOSE ETHERS PREPARED BY SAME

The present invention relates to a method for preparing acetylated cellulose ethers having improved anti-fouling properties and to acetylated cellulose ethers prepared by same. The method for preparing acetylated cellulose ethers having improved anti-fouling properties comprises the steps of: cross-linking cellulose ethers; and acetylating the cross-linked cellulose ethers. The acetylated cellulose ethers prepared by the method may activate the hydroxyl group which is made into blocks by the agglomeration between polymers performed by the materials for cross-linking the cellulose ethers, and may introduce thereto an additional hydrophilic group so as to increase hydrophilic properties, and thus may improve anti-fouling properties when applied to water-treatment membranes. 1. A method for preparing an acetylated cellulose ester having improved anti-fouling properties , comprising the steps of:cross-linking a cellulose ester; andacetylating the cross-linked cellulose ester.2. The method of claim 1 , wherein the cellulose ester has at least one substituent selected from the group consisting of methyl claim 1 , ethyl claim 1 , propyl claim 1 , hydroxymethyl claim 1 , hydroxyethyl claim 1 , and hydroxypropyl groups.3. The method of claim 1 , wherein the cellulose ester is at least one selected from the group consisting of methylcellulose claim 1 , hydroxypropyl methylcellulose claim 1 , and hydroxyethyl methylcellulose.4. The method of claim 1 , wherein a material for cross-linking the cellulose ester is at least one selected from the group consisting of glyoxal and glutaraldehyde.5. The method of claim 4 , wherein the material for cross-linking the cellulose ester is used at a content of 0.5 to 2.5% by weight claim 4 , based on the total weight of the cellulose ester.6. The method of claim 1 , wherein the acetylated cellulose ester has a degree of substitution with alkyl groups (DS) of 1 to 2 claim 1 , a degree of substitution with hydroxyalkyl groups (MS) of 0 to 1 ...

PARTIALLY CROSS-LINKED ESTERIFIED CELLULOSE ETHERS

A partially cross-linked esterified cellulose ether having A) groups of the formula —C(O)—R—COOA or a combination of aliphatic monovalent acyl groups and groups of the formula —C(O)—R—COOA, wherein R is a divalent aliphatic or aromatic hydrocarbon group and A is hydrogen or a cation, and B) having a molecular weight distribution such that [Wf(>100 k)−Wf(>100 k)XL]/Wf(>100 k)XL is at least 0.20, wherein Wf(>100 k) is the total weight fraction of the esterified cellulose ether that exceeds 100,000 g/mol, and Wf(>100 k)XL is the weight fraction that exceeds 100,000 g/mol of the methylated esterified cellulose ether is useful as enteric polymer for pharmaceutical dosage forms. 1. A partially cross-linked esterified cellulose ether havingA) groups of the formula —C(O)—R—COOA or a combination of aliphatic monovalent acyl groups and groups of the formula —C(O)—R—COOA, wherein R is a divalent aliphatic or aromatic hydrocarbon group and A is hydrogen or a cation, andB) having a molecular weight distribution such that[Wf(>100 k)−Wf(>100 k)XL]/Wf(>100 k)XL is at least 0.20,wherein Wf(>100 k) is the total weight fraction of the esterified cellulose ether that exceeds 100,000 g/mol, and Wf(>100 k)XL is the weight fraction that exceeds 100,000 g/mol of the esterified cellulose ether that has been subjected to methylation after production of the esterified cellulose etherwherein Wf(>100 k) and Wf(>100 k)XL are determined by Size Exclusion Chromatography using tetrahydrofuran as eluent and polystyrene calibration standards.2. The esterified cellulose ether of wherein the groups of the formula{'sub': 2', '2', '6', '4, '—C(O)—R—COOA are —C(O)—CH—CH—COOA, —C(O)—CH═CH—COOA, or —C(O)—CH—COOA and the aliphatic monovalent acyl groups are acetyl, propionyl or butyryl groups.'}3. The esterified cellulose ether of being hydroxypropyl methyl cellulose acetate succinate.4. The esterified cellulose ether of having a viscosity of up to 4.0 mPas claim 1 , measured as a 2.0 wt % solution of the ...

Process of preparing an esterified cellulose ether in the presence of an alkali metal carboxylate and an aliphatic carboxylic acid

In a process for preparing an esterified cellulose ether a cellulose ether is esterified with (i) an aliphatic monocarboxylic acid anhydride or (ii) a dicarboxylic acid anhydride or (iii) a combination of an aliphatic monocarboxylic acid anhydride and a dicarboxylic acid anhydride in the presence of an alkali metal carboxylate and an aliphatic carboxylic acid, wherein the molar ratio [alkali metal carboxylate/anhydroglucose units of cellulose ether] is not more than [1.20/1] and the molar ratio [aliphatic carboxylic acid/anhydroglucose units of cellulose ether] is from [3.55/1] to [9.0/1].

A PROCESS FOR RECOVERING AN ESTERIFIED CELLULOSE ETHER FROM A REACTION PRODUCT MIXTURE

A process for recovering an esterified cellulose ether from a reaction product mixture obtained from a reaction of (a) a cellulose ether with (b) an aliphatic monocarboxylic acid anhydride or a di- or tricarboxylic acid anhydride or a combination of an aliphatic monocarboxylic acid anhydride and a di- or tricarboxylic acid anhydride, comprises the steps of (i) contacting the reaction product mixture with an aqueous liquid to precipitate the esterified cellulose ether from the reaction product mixture, (ii) isolating the precipitated esterified cellulose ether from the mixture obtained in step (i), and (iii) suspending the isolated esterified cellulose ether in an aqueous liquid to provide a suspension having a temperature of at least 28° C., and (iv) recovering the esterified cellulose ether from the suspension of step (iii). 1. A process for recovering an esterified cellulose ether from a reaction product mixture obtained from a reaction of (a) a cellulose ether with (b) a di- or tricarboxylic acid anhydride or a combination of an aliphatic monocarboxylic acid anhydride and a di- or tricarboxylic acid anhydride , wherein the process comprises the steps of(i) contacting the reaction product mixture with an aqueous liquid to precipitate the esterified cellulose ether from the reaction product mixture,(ii) isolating the precipitated esterified cellulose ether from the mixture obtained in step (i),(iii) suspending the isolated esterified cellulose ether in an aqueous liquid to provide a suspension having a temperature of at least 28° C., and(iv) recovering the esterified cellulose ether from the suspension of step (iii).2. The process of wherein the aqueous liquid is water.3. The process of wherein the suspension in step (iii) has a temperature of from 30 to 95° C.4. The process of wherein the suspension in step (iii) has a temperature of from 55 to 90° C.5. The process of wherein in step (i) the combination of aqueous liquid and the reaction product mixture is ...

ESTERIFIED CELLULOSE ETHERS OF LOW ACETONE-INSOLUBLE CONTENT

Esterified cellulose ethers which have i) as ester groups aliphatic monovalent acyl groups or groups of the formula —C(O)—R—COOA or a combination of aliphatic monovalent acyl groups and groups of the formula —C(O)—R—COOA, wherein R is a divalent aliphatic or aromatic hydrocarbon group and A is hydrogen or a cation, and ii) a content of not more than 0.85 weight percent acetone-insoluble esterified cellulose ether particles, when the esterified cellulose ether is present in a mixture of 12.5 weight parts of esterified cellulose ether and 87.5 weight parts of acetone at 21° C., the weight percent acetone-insoluble esterified cellulose ether particles being based on the total weight of the esterified cellulose ether, wherein iii) not more than 14 percent of the acetone-insoluble esterified cellulose ether particles have a particle size of more than 90 micrometers. 1. An esterified cellulose ether havingi) as ester groups aliphatic monovalent acyl groups or groups of the formula —C(O)—R—COOA or a combination of aliphatic monovalent acyl groups and groups of the formula —C(O)—R—COOA, wherein R is a divalent aliphatic or aromatic hydrocarbon group and A is hydrogen or a cation, andii) a content of not more than 0.85 weight percent acetone-insoluble esterified cellulose ether particles, when the esterified cellulose ether is present in a mixture of 12.5 weight parts of esterified cellulose ether and 87.5 weight parts of acetone at 21° C., the weight percent acetone-insoluble esterified cellulose ether particles being based on the total weight of the esterified cellulose ether, wherein iii) not more than 14 percent of the acetone-insoluble esterified cellulose ether particles have a particle size of more than 90 micrometers, the percentage being based on the total number of acetone-insoluble esterified cellulose ether particles.2. The esterified cellulose ether of having a content of not more than 0.50 weight percent acetone-insoluble esterified cellulose ether particles ...

Acetylated cellulose ether, method for preparing same, and article comprising the acetylated cellulose ether

Disclosed are acetylated cellulose ether, a method of preparing the same, and an article including the same. The disclosed acetylated cellulose ether has a degree of substitution (DS) of alkyl group of 1 to 2, a molar substitution (MS) of hydroxyalkyl group of 0 to 1, and a degree of substitution (DS) of acetyl group of 1 to 2; and a bulk density of 0.1 to 0.4.

HYPROMELLOSE ACETATE SUCCINATE, METHOD FOR PRODUCING THE SAME AND COMPOSITION CONTAINING THE SAME

Provided are hypromellose acetate succinate (HPMCAS) which exhibits high solubility and can suppress generation of undissolved materials when dissolved in a solvent; an HPMCAS-containing composition; and a method for producing the HPMCAS. More specifically, provided are HPMCAS having a ratio of 2-position MS to 3-position MS of 1.2 or less, wherein the 2-position MS means a molar substitution of hydroxypropyl group by which a hydrogen atom of a hydroxyl group on 2-position carbon of each glucose unit of the HPMCAS has been directly replaced, and the 3-position MS means a molar substitution of hydroxypropyl group by which a hydrogen atom of a hydroxyl group on 3-position carbon of each glucose unit of the HPMCAS has been directly replaced; a composition comprising the HPMCAS and a solvent; and the method for producing the HPMCAS. 1. Hypromellose acetate succinate having a ratio of 2-position MS to 3-position MS of 1.2 or less , wherein the 2-position MS means a molar substitution of hydroxypropyl group by which a hydrogen atom of a hydroxyl group on 2-position carbon of each glucose unit of the hypromellose acetate succinate has been directly replaced , and the 3-position MS means a molar substitution of hydroxypropyl group by which a hydrogen atom of a hydroxyl group on 3-position carbon of each glucose unit of the hypromellose acetate succinate has been directly replaced.2. The hypromellose acetate succinate according to claim 1 , wherein a 10% by weight solution of the hypromellose acetate succinate in an aqueous alkali solution has a transmittance of 70% or more.3. The hypromellose acetate succinate according to claim 2 , wherein the aqueous alkali solution is aqueous ammonia.4. A composition comprising the hypromellose acetate succinate according to and a solvent.5. The composition according to claim 4 , wherein the composition is adapted for use as a coating composition.6. The composition according to claim 4 , wherein the solvent is aqueous ammonia.7. A method ...

PROCESS FOR PREPARING AN ESTER OF A CELLULOSE ETHER IN THE PRESENCE OF ACETIC ACID AND A REACTION CATALYST

A process for preparing an esterified cellulose ether comprises the step of esterifying a cellulose ether with (i) an aliphatic monocarboxylic acid anhydride or (ii) a dicarboxylic acid anhydride or (iii) a combination of an aliphatic monocarboxylic acid anhydride and a dicarboxylic acid anhydride in the presence of acetic acid. The esterification reaction is conducted in the presence of an alkali metal diacetate as a reaction catalyst. 1. A process for preparing an esterified cellulose ether comprising the step of esterifying a cellulose ether with (i) an aliphatic monocarboxylic acid anhydride or (ii) a dicarboxylic acid anhydride or (iii) a combination of an aliphatic monocarboxylic acid anhydride and a dicarboxylic acid anhydride , wherein the esterification reaction is conducted in the presence of acetic acid and an alkali metal diacetate.2. The process of wherein the alkali metal diacetate is sodium diacetate.3. The process of wherein the molar ratio [acetic acid/anhydroglucose units of cellulose ether] is from [1.2:1] to [20:1].4. The process of wherein the molar ratio [acetic acid/anhydroglucose units of cellulose ether] is from [1.5:1] to [12:1].5. The process of wherein the molar ratio [alkali metal diacetate/anhydroglucose units of cellulose ether] is from [0.4:1] to [5:1].6. The process of wherein the molar ratio [alkali metal diacetate/anhydroglucose units of cellulose ether] is from [1.0:1] to [3.8:1].7. The process of wherein the cellulose ether has a viscosity of from 1.8 to 100 mPa·s claim 1 , measured as a 2.0% by weight solution in water at 20° C. according to Ubbelohde.8. The process of wherein the cellulose ether is an alkyl cellulose claim 1 , a hydroxyalkylcellulose or a hydroxyalkyl alkylcellulose.9. The process of wherein the aliphatic monocarboxylic acid anhydride is selected from the group consisting of acetic anhydride claim 1 , butyric anhydride and propionic anhydride and the dicarboxylic acid anhydride is selected from the group ...

CELLULOSE ETHERS ESTERIFIED WITH DICARBOXYLIC ACID

Esterified cellulose ethers comprising groups of formula —C(O)—CHR′—CHR″—COOA, wherein, R′ and R″ are hydrogen or (—S)m (—R)n-R, wherein Ris a hydrocarbon group having 1 to 4 carbon atoms, Ris an optionally substituted 5- or 6-membered cyclic group, m and n each independently are 0 or 1, and A is hydrogen or a cation, with the proviso that in each group CHR′—CHR″ one of R′ and R″ is hydrogen and the other one is (—S)m (—R)n-R′, are useful as excipients for maintaining the concentration of poorly water-soluble drugs in aqueous liquids at supersaturation levels. 1. An esterified cellulose ether comprising groups of formula{'br': None, '—C(O)—CHR′—CHR″—COOA,'}{'sub': m', 'n, 'sup': 2', '1', '2, 'wherein R′ and R″ are hydrogen or (—S)(—R′)—R, wherein Ris a hydrocarbon group having 1 to 4 carbon atoms, Ris an optionally substituted 5- or 6-membered cyclic group, m and n each independently are 0 or 1, and A is hydrogen or a cation,'}{'sub': m', 'n, 'sup': '2', 'with the proviso that in each group CHR′—CHR″ one of R′ and R″ is hydrogen and the other one is (—S)(—R′)—R.'}2. The esterified cellulose ether of wherein Ris CH.3. The esterified cellulose ether of wherein Ris non-substituted 5- or 6-membered cyclic group.4. The esterified cellulose ether of wherein m=1.5. The esterified cellulose ether of wherein m=0.6. The esterified cellulose ether of wherein n=0.7. The esterified cellulose ether of wherein Ris cyclohexyl or phenyl.8. The esterified cellulose ether of being an esterified hydroxyalkyl methylcellulose.9. A composition comprising a liquid diluent and at least one esterified cellulose ether of .10. The composition of additionally comprising at least one active ingredient and optionally one or more adjuvants.11. A solid dispersion comprising at least one active ingredient dispersed in at least one esterified cellulose ether of .12. The solid dispersion of wherein the solid dispersion has been formulated into tablets claim 11 , pills claim 11 , granules claim 11 , ...

HYPROMELLOSE ACETATE SUCCINATE POWDER EXCELLENT IN DISSOLVED STATE AND PRODUCTION METHOD THEREOF, AND PRODUCTION METHODS FOR COMPOSITION FOR SOLID DISPERSION, COATING COMPOSITION, DRUG-CONTAINING PARTICLE, AND SOLID PREPARATION

Provided are HPMCAS powder having high solubility when dissolved in a solvent and being capable of suppressing generation of undissolved materials; and a method for producing the powder. More specifically, provided is hypromellose acetate succinate powder having an average ratio of L to D of from 2.0 to 3.0, wherein L and D mean maximum and minimum diameters of each particle, respectively. Also provided is a method for producing a hypromellose acetate succinate, comprising the steps of: dissolving hypromellose powder in a solvent, esterifying the dissolved hypromellose with succinic anhydride and acetic anhydride in the presence of a catalyst to obtain a reaction mixture, and mixing the reaction mixture with water to precipitate hypromellose acetate succinate, wherein the reaction mixture just before being mixed with the water has a viscosity of from 100 to 200 Pa·s. 1. Hypromellose acetate succinate powder having an average ratio of L to D of from 2.0 to 3.0 , wherein L and D mean maximum and minimum diameters of each particle , respectively.2. The hypromellose acetate succinate powder according to claim 1 , having a specific surface area of from 2.0 to 5.0 m/g or more.3. The hypromellose acetate succinate powder according to claim 1 , having a loose bulk density of from 0.10 to 0.25 g/mL.4. The hypromellose acetate succinate powder according to claim 1 , comprising 10% by weight or less of component not soluble at 20° C. in such a weight of acetone as to be 10 times the weight of the powder.5. A method for producing a composition for solid dispersion claim 1 , comprising the step of removing a solvent from a solution comprising the hypromellose acetate succinate powder according to claim 1 , a drug and the solvent.6. A method for producing a coating composition claim 1 , comprising the step of dissolving the hypromellose acetate succinate powder according to in a solvent which is a mixed solution of water and an alcohol claim 1 , or an aqueous ammonia solution.7. ...

AQUEOUS COMPOSITION COMPRISING DISPERSED ESTERIFIED CELLULOSE ETHER

An aqueous composition which is useful for producing coatings and capsule shells comprises a) dispersed particles of an esterified cellulose ether comprising (i) groups of the formula —C(O)—R—COOA or (ii) a combination of aliphatic monovalent acyl groups and groups of the formula —C(O)—R—COOA, wherein R is a divalent hydrocarbon group and A is hydrogen or a cation, and the total degree of ester substitution is more than 0.70, and b) an esterified cellulose ether comprising aliphatic monovalent acyl groups and groups of the formula —C(O)—R—COOH, R being a divalent hydrocarbon group, wherein I) the degree of neutralization of the groups —C(O)—R—COOH is not more than 0.4, II) the total degree of ester substitution is from 0.03 to 0.70, and III) the esterified cellulose ether b) has a solubility in water of at least 2.0 weight percent at 2° C. 2. The aqueous composition of comprising at least 15 percent of the dispersed particles a) claim 1 , based on the total weight of the aqueous composition.3. The aqueous composition of comprising at least 2 percent of the esterified cellulose ether b) claim 1 , based on the total weight of the aqueous composition.4. The aqueous composition of claim 1 , wherein the median particle size claim 1 , d50 claim 1 , of the dispersed esterified cellulose ether particles a) is up to 7 micrometers claim 1 , such median particle size (d50) being the size at which 50 volume percent of the particles have a smaller equivalent diameter and 50 volume percent have a larger equivalent diameter.5. The aqueous composition of claim 1 , wherein the total degree of ester substitution of the dispersed esterified cellulose ether particles a) is from 0.75 to 1.10.6. The aqueous composition of claim 1 , wherein the total degree of ester substitution of the esterified cellulose ether b) is from 0.20 to 0.60.7. The aqueous composition of wherein the aqueous composition additionally comprises c) 0.05 to 20 percent of a salt of a fatty acid claim 1 , based on the ...

METHODS AND COMPOSITIONS FOR WEIGHT MANAGEMENT AND FOR IMPROVING GLYCEMIC CONTROL

The present invention provides methods, compositions and modified foods and foodstuffs useful for weight management and glycemic control. 1. A modified food or foodstuff comprising an edible polymer hydrogel.248-. (canceled)49. A method of enhancing glycemic control in a subject in need thereof , comprising the step of orally administering to the subject an effective amount of an edible polymer hydrogel wherein said edible polymer hydrogel swells in the subject's stomach , the subject's small intestine or both.50. The method of claim 49 , wherein the edible polymer hydrogel is administered to the subject with food or up to two hours prior to eating.51. The method of claim 49 , wherein the edible polymer hydrogel has a swelling ratio of more than 40.52. The method of claim 49 , wherein the edible polymer hydrogel has an elastic modulus of at least 200 Pa.53. The method of claim 49 , wherein the edible polymer hydrogel has a viscosity of at least 15 s.54. The method of claim 49 , wherein the edible polymer hydrogel swells in both the stomach and small intestine of the subject.55. The method of claim 49 , wherein the edible polymer hydrogel swells in the subject's small intestine but not in the subject's stomach.56. The method of claim 55 , wherein the edible polymer hydrogel is administered with an enteric coating.57. The method of claim 49 , wherein the subject is obese claim 49 , overweight or normal weight.58. The method of claim 49 , wherein the edible polymer hydrogel is administered in an amount sufficient to increase the viscosity and elastic modulus of the gastrointestinal content and slow gastric emptying and absorption of carbohydrates and fats in the subject's small intestine.59. The method of claim 49 , wherein the polymer gel comprises a hydrophilic polymer cross-linked with a polycarboxylic acid.60. The method of claim 59 , wherein the hydrophilic polymer is an anionic polymer.61. The method of claim 60 , wherein the anionic polymer is ...

METHOD FOR PREPARING HYDROXYPROPYL METHYLCELLULOSE ACETATE SUCCINATE (HPMCAS) GRAINS HAVING CONTROLLED GRAIN SIZE DISTRIBUTION, AND HPMCAS POWDER

Disclosed are a method for preparing hydroxypropyl methylcellulose acetate succinate (HPMCAS) grains and HPMCAS grains. The disclosed method for preparing HPMCAS grains comprises: a step of esterifying hydroxypropyl methylcellulose (HPMC), acetic anhydride, and succinic anhydride in a reaction medium in the presence of a catalyst so as to obtain a reaction solution containing HPMCAS (esterification step); and a step of continuously or intermittently putting the reaction solution into water so as to form grains (granulating step). 1. A method of preparing hydroxypropyl methylcellulose acetate succinate (HPMCAS) grains , the method comprising:obtaining a reaction solution comprising HPMCAS by esterifying hydroxypropyl methylcellulose (HPMC), acetic anhydride, and succinic anhydride in a reaction medium in the presence of a catalyst (esterification step); andforming grains by continuously or intermittently adding the reaction solution to water (granulating step).2. The method of claim 1 , wherein temperatures of the reaction solution and water used in the granulating step are in the range of 45 to 60° C. and in the range of 20 to 30° C. claim 1 , respectively.3. The method of claim 1 , wherein a total amount of water used in the granulating step is 12 to 20 times greater than a total amount of the reaction medium used in the esterification step.4. Hydroxypropyl methylcellulose acetate succinate (HPMCAS) powder prepared according to the method of claim 1 , wherein a fraction of grains having a size of 841 to 1 claim 1 ,190 μm is 25 wt % or greater.5. The HPMCAS powder of claim 4 , wherein the HPMCAS powder comprises HPMCAS grains having a degree of substitution of acetyl group of 0.3 to 0.75 claim 4 , a degree of substitution of methoxyl group of 1.6 to 2.0 claim 4 , a degree of substitution of hydroxypropoxyl group of 0.2 to 0.3 claim 4 , and a degree of substitution of succinoyl group of 0.1 to 0.45 per glucose unit.6. Hydroxypropyl methylcellulose acetate succinate ( ...

NOVEL ESTERIFIED CELLULOSE ETHERS OF LOW VISCOSITY AND HIGH MOLECULAR WEIGHT

Esterified cellulose ethers which comprise (i) aliphatic monovalent acyl groups or (ii) groups of the formula —C(O)—R—COOA, wherein R is a divalent aliphatic or aromatic hydrocarbon group and A is hydrogen or a cation, or (iii) a combination of aliphatic monovalent acyl groups and groups of the formula —C(O)—R—COOA, 1. A process for producing a hydroxypropyl methyl cellulose acetate succinate (HPMCAS) polymer sample having the viscosity of up to 2.33 mPa·s measured as a 2.0 wt % solution of the HPMCAS in 0.43 wt % aqueous NaOH at 20° C. , having the viscosity of up to 19 mPa·s measured as a 10 wt % solution of the HPMCAS in acetone at 20° C. , and having a weight average molecular weight Mof at least 90 ,000 Dalton measured by SEC-MALLS using as mobile phase a mixture produced from 40 parts by volume of acetonitrile and 60 parts by volume of aqueous buffer containing 50 mM NaHPOand 0.1 M NaNOwherein a hydroxypropyl methyl cellulose having a viscosity of from 1.20 to 2.33 mPa·s measured as a 2 wt.-% solution in water at 20° C. is esterified with acetic anhydride and succinic anhydride in the presence of an aliphatic carboxylic acid as a reaction diluent and an alkali metal carboxylate as an esterification catalyst, wherein the molar ratio [aliphatic carboxylic acid/anhydroglucose units of cellulose ether] is up to 8.0/1.0 and the molar ratio [alkali metal carboxylate/anhydroglucose units of cellulose ether] is from [0.4/1.01] to [3.8/1.0].2. The process of for producing a HPMCAS polymer sample having a number average molecular weight Mof 12 claim 1 ,000 Dalton to 51 claim 1 ,000 Dalton and an Mof 649 claim 1 ,000 to 1 claim 1 ,694 claim 1 ,000 Dalton measured by SEC-MALLS using as mobile phase a mixture produced from 40 parts by volume of acetonitrile and 60 parts by volume of aqueous buffer containing 50 mM NaHPOand 0.1 M NaNO.3. The process of for producing a HPMCAS polymer sample having the viscosity of up to 2.25 mPa·s measured as a 2.0 wt % solution of the ...

Method of preparing acetylated cellulose ether

Disclosed is a method of preparing an acetylated cellulose ether. The disclosed method of preparing acetylated cellulose ether includes converting a cellulose ether to an acetylated cellulose ether in the presence of an acid catalyst.

PROCESS FOR PRODUCING A CELLULOSE ETHER ACETATE SUCCINATE

A process for producing a cellulose ether acetate succinate comprises the step of reacting a cellulose ether with acetic anhydride, succinic anhydride and an depolymerizing agent, wherein the cellulose ether has an initial viscosity of at least 50 mPa-s, measured as a 2 weight-% solution in water at 20° C., and the reaction of the cellulose ether with acetic anhydride, succinic anhydride and the depolymerizing agent is conducted simultaneously or in sequence in one reaction device. 1. A process for producing a cellulose ether acetate succinate comprising the step of reacting a cellulose ether with acetic anhydride and succinic anhydride in the presence of an aliphatic carboxylic acid and with a depolymerizing agent , wherein the cellulose ether has an initial viscosity of at least 50 mPa·s , measured as a 2 weight-% solution in water at 20° C. , the depolymerizing agent is an inorganic acid or an oxidizing agent different from oxygen and the reaction of the cellulose ether with acetic anhydride , succinic anhydride and the depolymerizing agent is conducted simultaneously or in sequence in one reaction device.2. The process of wherein the cellulose ether has a viscosity of at least 500 mPa·s claim 1 , measured as a 2 weight-% solution in water at 20° C.3. The process of wherein the cellulose ether has a viscosity of at least 1000 mPa·s claim 1 , measured as a 2 weight-% solution in water at 20° C.4. The process of wherein a reaction mixture comprising the cellulose ether claim 1 , acetic anhydride claim 1 , succinic anhydride and the depolymerizing agent is prepared and the reaction mixture is subsequently heated to conduct the esterification reaction.5. The process of wherein the amount of the depolymerizing agent is at least 0.03 mole per mole of anhydroglucose units of the cellulose ether.6. The process of wherein the depolymerizing agent is selected from the group consisting of alkali metal chlorites claim 1 , alkali metal chlorates claim 1 , alkali metal ...

PROCESS FOR PREPARING AN ESTER OF A CELLULOSE ETHER

A process for producing an esterified cellulose ether comprises the step of reacting a cellulose ether with an aliphatic monocarboxylic acid anhydride and/or a dicarboxylic acid anhydride and with a depolymerizing agent, wherein the cellulose ether has an initial viscosity of at least 500 mPa·s, measured as a 2 weight-% solution in water at 20° C., and the reaction of the cellulose ether with the aliphatic monocarboxylic acid anhydride and/or the dicarboxylic acid anhydride and with the depolymerizing agent is conducted simultaneously or in sequence in one reaction device. 1. A process for producing an esterified cellulose ether comprising the step of reacting a cellulose ether with an aliphatic monocarboxylic acid anhydride and/or a dicarboxylic acid anhydride in the presence of up to 2000 weight parts of an aliphatic carboxylic acid per 100 weight parts of cellulose ether and with a depolymerizing agent , wherein the cellulose ether has an initial viscosity of at least 500 mPa·s , measured as a 2 weight-% solution in water at 20° C. , the depolymerizing agent is an inorganic acid or an oxidizing agent different from oxygen and the reaction of the cellulose ether with the aliphatic monocarboxylic acid anhydride and/or the dicarboxylic acid anhydride and with the depolymerizing agent is conducted simultaneously or in sequence in one reaction device.2. The process of wherein the cellulose ether has a viscosity of at least 1000 mPa·s claim 1 , measured as a 2 weight-% solution in water at 20° C.3. The process of wherein a reaction mixture comprising the cellulose ether claim 1 , the aliphatic monocarboxylic acid anhydride and/or the dicarboxylic acid anhydride and the depolymerizing agent is prepared and the reaction mixture is subsequently heated to conduct the esterification reaction.4. The process of wherein the amount of the depolymerizing agent is at least 0.03 mole per mole of anhydroglucose units of the cellulose ether.5. The process of wherein the ...

NOVEL ESTERIFIED CELLULOSE ETHERS OF HIGH MOLECULAR WEIGHT AND HOMOGENEITY

Esterified cellulose ethers which have i) as ester groups aliphatic monovalent acyl groups or a combination of aliphatic monovalent acyl groups and groups of the formula ——C(O)—R—COOA wherein R is a divalent aliphatic or aromatic hydrocarbon group and A is hydrogen or a cation, ii) a weight average molecular weight Mof from 80,000 Dalton to 220,000 Dalton, iii) a Polydispersity M/Mof from 1.3 to 4.0, and iv) an M/Mof not more than 18.5, when the weight average molecular weight Mthe number average molecular weight Mn and the z-average molecular weight Mare measured by SEC-MALLS using as mobile phase a mixture produced from 40 parts by volume of acetonitrile and 60 parts by volume of aqueous buffer containing 50 mM NaH—POand 0.1 M NaNO. are useful as enteric polymers for pharmaceutical dosage forms. 2. The esterified cellulose ether of wherein the aliphatic monovalent acyl groups are acetyl claim 1 , propionyl or butyryl groups and the groups of the formula —C(O)—R—COOA are —C(O)—CH—CH—COOA claim 1 , —C(O)—CH═CH—COOA claim 1 , or —C(O)—CH—COOA.3. The esterified cellulose ether of being hydroxypropyl methyl cellulose acetate succinate.4. The esterified cellulose ether of having a weight average molecular weight Mof from 90 claim 1 ,000 to 185 claim 1 ,000 Dalton.5. The esterified cellulose ether of having an M/Mof from 1.5 to 3.5 or an M/Mof from 3.0 to 17.0 claim 1 , or a combination thereof.6. A composition comprising a liquid diluent and at least one esterified cellulose ether of .7. The composition of additionally comprising at least one active ingredient and optionally one or more adjuvants.8. A solid dispersion comprising at least one active ingredient in at least one esterified cellulose ether of .9. The solid dispersion of in the form of strands claim 8 , pellets claim 8 , granules claim 8 , pills claim 8 , tablets claim 8 , caplets claim 8 , microparticles claim 8 , fillings of capsules or injection molded capsules or in the form of a powder claim 8 , film ...

NOVEL ESTERIFIED CELLULOSE ETHERS OF LOW VISCOSITY AND HIGH MOLECULAR WEIGHT

Esterified cellulose ethers which comprise (i) aliphatic monovalent acyl groups or (ii) groups of the formula —C(O)—R—COOA, wherein R is a divalent aliphatic or aromatic hydrocarbon group and A is hydrogen or a cation, or (iii) a combination of aliphatic monovalent acyl groups and groups of the formula —C(O)—R—COOA, which have a viscosity of up 19 mPa·s, measured as a 10 wt % solution of the esterified cellulose ether in acetone at 20° C., and which have a weight average molecular weight Mof at least 90,000 Dalton, are useful for preparing solid dispersions comprising drugs. 1. An esterified cellulose ether comprising (i) aliphatic monovalent acyl groups or (ii) groups of the formula —C(O)—R—COOA , wherein R is a divalent aliphatic or aromatic hydrocarbon group and A is hydrogen or a cation , or (iii) a combination of aliphatic monovalent acyl groups and groups of the formula —C(O)—R—COOA ,having a viscosity of up to 19 mPa·s, measured as a 10 wt % solution of the esterified cellulose ether in acetone at 20° C., and{'sub': 'w', 'having a weight average molecular weight Mof at least 90,000 Dalton.'}2. The esterified cellulose ether of additionally having a viscosity of up to 2.33 mPa·s claim 1 , measured as a 2.0 wt % solution of the esterified cellulose ether in 0.43 wt % aqueous NaOH at 20° C.3. The esterified cellulose ether of or having a weight average molecular weight Mof from 90 claim 1 ,000 to 220 claim 1 ,000 Dalton and a viscosity of from 1.50 mPa·s to 15 mPa·s claim 1 , measured as a 10 wt % solution of the esterified cellulose ether in acetone at 20° C.4. The esterified cellulose ether of or having a weight average molecular weight Mof from 220 claim 1 ,000 to 350 claim 1 ,000 Dalton and a viscosity of from 5 to 18 mPa·s claim 1 , measured as a 10 wt % solution of the esterified cellulose ether in acetone at 20° C.5. The esterified cellulose ether of any one of to wherein the aliphatic monovalent acyl groups are acetyl claim 1 , propionyl or butyryl ...

NOVEL ESTERIFIED CELLULOSE ETHERS OF VERY HIGH MOLECULAR WEIGHT

Esterified cellulose ethers which comprise (i) groups of the formula —C(O)—R—COOA or (ii) a combination of aliphatic monovalent acyl groups and groups of the formula —C(O)—R—COOA, wherein R is a divalent aliphatic or aromatic hydrocarbon group and A is hydrogen or a cation, which have a viscosity of up 50 mPa·s, measured as a 10 wt % solution of the esterified cellulose ether in acetone at 20° C., and a weight average molecular weight Mof at least 220,000 Dalton, or which have a viscosity of up 100 mPa·s, measured as a 10 wt % solution of the esterified cellulose ether in acetone at 20° C., and a weight average molecular weight Mof at least 310,000 Dalton are useful for preparing solid dispersions comprising drugs. 1. An esterified cellulose ethercomprising (i) groups of the formula —C(O)—R—COOA or (ii) a combination of aliphatic monovalent acyl groups and groups of the formula —C(O)—R—COOA, wherein R is a divalent aliphatic or aromatic hydrocarbon group and A is hydrogen or a cation,having a viscosity of up to 50 mPa·s, measured as a 10 wt % solution of the esterified cellulose ether in acetone at 20° C., and{'sub': 'w', 'having a weight average molecular weight Mof at least 220,000 Dalton.'}2. The esterified cellulose of having a weight average molecular weight Mof at least 250 claim 1 ,000 Dalton.3. The esterified cellulose ether of having a viscosity of up 40 mPa·s claim 1 , measured as a 10 wt % solution of the esterified cellulose ether in acetone at 20° C.4. An esterified cellulose ethercomprising (i) groups of the formula —C(O)—R—COOA or (ii) a combination of aliphatic monovalent acyl groups and groups of the formula —C(O)—R—COOA, wherein R is a divalent aliphatic or aromatic hydrocarbon group and A is hydrogen or a cation,having a viscosity of up to 100 mPa·s, measured as a 10 wt % solution of the esterified cellulose ether in acetone at 20° C., and{'sub': 'w', 'having a weight average molecular weight Mof at least 310,000 Dalton.'}5. The esterified ...

Process for producing a water-soluble cellulose derivative having a reduced content of water-insoluble particles

A process for producing a water-soluble cellulose derivative of a reduced content of water-insoluble particles comprises the steps of a) reacting cellulose with an alkaline material to produce alkali cellulose, b) reacting the produced alkali cellulose with one or more derivatizing agents to produce a water-soluble cellulose derivative, c) washing the produced cellulose derivative with an aqueous liquid once or several times to provide a moist cellulose derivative having a water content of 25 to 85 percent, based on the total weight of the moist cellulose derivative, d) subjecting the moist cellulose derivative to homogenization to form the moist cellulose derivative to a paste, and e) pressing the paste through a filter of a pore size of up to 200 μm.

EFFICIENT PROCESS FOR PREPARING AN ESTER OF A CELLULOSE ETHER

A process for producing an esterified cellulose ether can be efficiently be produced by reacting a moist cellulose ether having a water content of at least 10 percent, based on the weight of the moist cellulose ether, with an aliphatic monocarboxylic acid anhydride, a dicarboxylic acid anhydride or a combination thereof. Further improvements in efficiency and reduction in process steps are achieved in a process for producing an esterified cellulose ether which comprises the steps of a) reacting cellulose with an alkaline material to produce alkali cellulose, b) reacting the produced alkali cellulose with one or more etherifying agents and washing the produced cellulose ether to obtain a moist cellulose ether having a water content of at least 10 weight percent, and c) reacting the moist cellulose ether with an aliphatic monocarboxylic acid anhydride and/or a dicarboxylic acid anhydride and with a depolymerizing agent. 1. A process for producing an esterified cellulose ether whereina moist cellulose ether having a water content of at least 10 percent, based on the weight of the moist cellulose ether, is reacted with an aliphatic monocarboxylic acid anhydride, a dicarboxylic acid anhydride or a combination thereof.2. The process of wherein the moist cellulose ether is additionally reacted with a depolymerizing agent simultaneously with or in sequence to the reaction with the aliphatic monocarboxylic acid anhydride and/or the dicarboxylic acid anhydride claim 1 , the depolymerizing agent being an inorganic acid or an oxidizing agent different from oxygen.3. A process for producing an esterified cellulose ethercomprising the steps ofa) reacting cellulose with an alkaline material to produce alkali cellulose,b) reacting the produced alkali cellulose with one or more etherifying agents and washing the produced cellulose ether to obtain a moist cellulose ether having a water content of at least 10 weight percent, andc) reacting the moist cellulose ether with an aliphatic ...

HYPROMELLOSE PHTHALATE AND METHOD FOR PRODUCING THE SAME

There is provided a method for producing hypromellose phthalate (HPMCP) which exhibits an excellent solubility when dissolved in a solvent, while suppressing formation of undissolved matter. More specifically, there is provided a method for producing HPMCP, including an esterification step of esterifying hypromellose dissolved in glacial acetic acid with phthalic anhydride in the presence of sodium acetate at a temperature of from 75 to 100° C. to obtain a reaction product solution; a cooling step of cooling the reaction product solution to 70° C. or lower; and a precipitation step of mixing the cooled reaction product solution with water of from 0 to 40° C. to obtain a suspension of precipitated HPMCP. 1. A method for producing hypromellose phthalate , comprising:an esterification step of esterifying hypromellose dissolved in glacial acetic acid with phthalic anhydride in the presence of sodium acetate at a temperature of from 75 to 100° C. to obtain a reaction product solution;a cooling step of cooling the reaction product solution to a temperature of 70° C. or lower; anda precipitation step of mixing the cooled reaction product solution with water of from 0 to 40° C. to obtain a suspension of precipitated hypromellose phthalate.2. The method for producing hypromellose phthalate according to claim 1 , wherein said cooling step comprises cooling the reaction product solution to a temperature of from 40 to 70° C.3. The method for producing hypromellose phthalate according to claim 1 , wherein claim 1 , in the precipitation step claim 1 , a temperature of the reaction product solution after mixed with the water is 55° C. or lower.4. The method for producing hypromellose phthalate according to claim 1 , further comprising claim 1 , between the cooling step and the precipitation step claim 1 , a step of mixing the cooled reaction product solution with such an amount of water of from 0 to 40° C. as not to cause precipitation of hypromellose phthalate.5. The method for ...

NOVEL ESTERIFIED CELLULOSE ETHERS OF LOW VISCOSITY

Esterified cellulose ethers which comprise (i) aliphatic monovalent acyl groups or (ii) groups of the formula —C(O)—R—COOA, wherein R is a divalent aliphatic or aromatic hydrocarbon group and A is hydrogen or a cation, or (iii) a combination of aliphatic monovalent acyl groups and groups of the formula —C(O)—R—COOA, which have a viscosity of up to 2.33 mPa·s, measured as a 2.0 wt % solution of the esterified cellulose ether in 0.43 wt % aqueous NaOH at 20° C., and which have a viscosity of up to 13 mPao·s, measured as a 10 wt % solution of the esterified cellulose ether in acetone at 20° C. are useful for preparing solid dispersions comprising drugs. 1. An esterified cellulose ethercomprising (i) aliphatic monovalent acyl groups or (ii) groups of the formula —C(O)—R—COOA, wherein R is a divalent aliphatic or aromatic hydrocarbon group and A is hydrogen or a cation, or (iii) a combination of aliphatic monovalent acyl groups and groups of the formula —C(O)—R—COOA,having a viscosity of up to 2.33 mPa·s, measured as a 2.0 wt % solution of the esterified cellulose ether in 0.43 wt % aqueous NaOH at 20° C., andhaving a viscosity of up to 13 mPa·s, measured as a 10 wt % solution of the esterified cellulose ether in acetone at 20° C.2. The esterified cellulose ether of having a viscosity of from 1.20 to 1.80 mPa·s claim 1 , measured as a 2.0 wt % solution of the esterified cellulose ether in 0.43 wt % aqueous NaOH at 20° C.3. The esterified cellulose ether of or having a viscosity of up to 10 mPa·s claim 1 , measured as a 10 wt % solution of the esterified cellulose ether in acetone at 20° C.4. The esterified cellulose ether of having a viscosity of up to 3 mPa·s claim 3 , measured as a 10 wt % solution of the esterified cellulose ether in acetone at 20° C.5. The esterified cellulose ether of any one of to wherein the aliphatic monovalent acyl groups are acetyl claim 3 , propionyl or butyryl groups and the groups of the formula —C(O)—R—COOA are —C(O)—CH—CH—COOA claim 3 , —C ...

NOVEL ESTERIFIED CELLULOSE ETHERS OF VERY LOW VISCOSITY

An esterified cellulose ether which comprises (i) aliphatic monovalent acyl groups or (ii) groups of the formula —C(O)—R—COOA, wherein R is a divalent aliphatic or aromatic hydrocarbon group and A is hydrogen or a cation, or (iii) a combination of aliphatic monovalent acyl groups and groups of the formula —C(O)—R—COOA, and which has a) a viscosity of from 1.2 to 1.8 mPaos, measured as a 2.0 wt % solution of the esterified cellulose ether in 0.43 wt % aqueous NaOH at 20° C., or b) a viscosity of up to 5 mPa·s, measured as a 10 wt % solution of the esterified cellulose ether in acetone at 20° C., or c) a combination of the viscosities of a) and b), is useful for preparing solid dispersions comprising drugs. 1. An esterified cellulose ethercomprising (i) aliphatic monovalent acyl groups or (ii) groups of the formula —C(O)—R—COOA, wherein R is a divalent aliphatic or aromatic hydrocarbon group and A is hydrogen or a cation, or (iii) a combination of aliphatic monovalent acyl groups and groups of the formula —C(O)—R—COOA,wherein the esterified cellulose ether has a viscosity of up to 5 mPa·s, measured as a 10 wt % solution of the esterified cellulose ether in acetone at 20° C.2. The esterified cellulose ether of having a) a viscosity of from 1.2 to 1.8 mPa·s claim 1 , measured as a 2.0 wt % solution of the esterified cellulose ether in 0.43 wt % aqueous NaOH at 20° C. claim 1 , and b) a viscosity of up to 5 mPa·s claim 1 , measured as a 10 wt % solution of the esterified cellulose ether in acetone at 20° C.3. The esterified cellulose ether of having a viscosity of up to 3 mPa·s claim 1 , measured as a 10 wt % solution of the esterified cellulose ether in acetone at 20° C.4. The esterified cellulose ether of having a viscosity of from 1.20 to 1.70 mPa·s claim 1 , measured as a 2.0 wt % solution of the esterified cellulose ether in 0.43 wt % aqueous NaOH at 20° C.5. The esterified cellulose ether of wherein the aliphatic monovalent acyl groups are acetyl claim 1 , ...

PHARMACEUTICAL COMPOSITIONS WITH ENHANCED PERFORMANCE AND IMPROVED PROCESSABILITY

The presently disclosed and claimed inventive concept(s) relates to a polymer for enhancing drug performance and improving processability. Specifically, the polymer comprises hydroxypropyl methyl cellulose acetate succinate (HPMC-AS). On the HPMC-AS, the percentage of total succinoyl degree of substitution is less than 12% at C6-OH position and greater than 53% at C3-OH, and the percentage of total acetyl degree of substitution is greater than 32% at C6-OH position. 111.-. (canceled)12. A method for making hydroxypropyl methyl cellulose acetate succinate (HPMC-AS) having a percentage of a total degree of substitution (DS) of succinoyl less than 12% at a C6-OH position (% C6DSSuc<12%) and greater than 53% at a C3-OH position (% C3DSSuc>53%) , and a percentage of total DS of acetyl greater than 32% at a C6-OH position (% C6DSAc>32%) , comprising the steps of:(a) reacting acetic anhydride and sodium acetate with hydroxyl propyl methylcellulose to form an intermediate at a temperature in a range from about 85 to about 115° C.;(b) keeping the temperature for a certain period of time; and(c) reacting succinic anhydride with the intermediate at the temperature for a certain period of time to form HPMC-AS.13. The method of claim 12 , wherein the HPMC-AS has a percentage of a total DS of acetyl less than 27% at a C3-OH position (% C3DSAc<27%).14. The method of claim 12 , wherein the time in step (b) is varied from 30 minutes to about 2.5 hours.15. The method of claim 12 , wherein the time in step (c) is varied from 2.5 hours to 23.5 hours.16. The method of claim 15 , wherein the time in step (c) is varied from 2.5 hours to 15.5 hours.17. The method of claim 16 , wherein the time in step (c) is varied from 2.5 hours to 5.5 hours.18. The method of claim 12 , wherein the temperature is in a range from 95 to 115° C.19. The method of claim 12 , wherein the temperature is in a range from 95 to 110° C. The present application is a divisional of U.S. Ser. No. 14/186,147, filed Feb. ...

Use of special screens in the preparation of cellulose powder

본 발명은, 셀룰로스 분말의 제조 방법에서 상이한 메쉬 또는 공극 크기의 2개 이상의 층을 포함하는 스크린의 용도뿐만 아니라, 셀룰로스 펄프의 분쇄 및 수득된 입자들의 체질을 연속식으로 수행할 수 있는 상기 제조 방법에 관한 것이다. The present invention relates to a process for the production of cellulose powders which comprises the use of a screen comprising two or more layers of different mesh or pore size as well as the use of the screening process for the pulverization of cellulosic pulp and the sieving of the obtained particles . 셀룰로스 분말, 상이한 메쉬 또는 공극 크기, 스크린, 스크리닝 층, 지지 층, 셀룰로스 분말의 제조 방법. Cellulosic powder, different mesh or pore size, screen, screening layer, support layer, cellulose powder.

セルロ−スエ−テル酸性ジカルボン酸エステルの製造方法

(57)【要約】本公報は電子出願前の出願データであるた め要約のデータは記録されません。

新颖低粘度酯化纤维素醚

酯化纤维素醚适用于制备包含药物的固体分散液，所述酯化纤维素醚包含(i)脂肪族单价酰基；或(ii)式‑C(O)‑R‑COOA的基团，其中R为二价脂肪族或芳香族烃基并且A为氢或阳离子；或(iii)脂肪族单价酰基和式‑C(O)‑R‑COOA的基团的组合，在20℃下以酯化纤维素醚于0.43wt％NaOH水溶液中的2.0wt％溶液测量，其粘度高达2.33mPa·s，并且在20℃下以所述酯化纤维素醚于丙酮中的10wt％溶液测量，其粘度高达13mPao·s。

Methods and compositions for weight management and for improving glycemic control

초고분자량의 신규한 에스테르화된 셀룰로스 에테르

에스테르화된 셀룰로스 에테르로서, (i) 화학식 -C(O)-R-COOA의 그룹 또는 (ii) 지방족 1가 아실 그룹과 화학식 -C(O)-R-COOA의 그룹의 배합물을 포함하고, 여기서 R은 2가 지방족 또는 방향족 탄화수소 그룹이고, A는 수소 또는 양이온이며, 20℃에서 아세톤 중의 상기 에스테르화된 셀룰로스 에테르의 10중량% 용액으로서 측정된 바 50mPaㆍs 이하의 점도를 갖고 220,000달턴 이상의 중량 평균 분자량 M w 를 갖거나; 20℃에서 아세톤 중의 상기 에스테르화된 셀룰로스 에테르의 10중량% 용액으로서 측정된 바 100mPaㆍs 이하의 점도를 갖고 310,000달턴 이상의 중량 평균 분자량 M w 를 갖는 에스테르화된 셀룰로스 에테르는, 약물을 포함하는 고체 분산체의 제조에 유용하다.

Methods and compositions for weight management and for improving glycemic control

본 발명은 체중 관리 및 혈당 조절에 유용한 방법, 조성물 및 변형된 식품 또는 식품재료를 제공한다. The present invention provides methods, compositions and modified foods or food materials useful for weight management and blood glucose control.

堆肥化可能な熱可塑性セルロースエーテル−２−ヒドロキシカルボン酸エステルおよび混合エステル

(57)【要約】 （修正有） 【課題】 堆肥化可能な熱可塑性セルロースエーテル− ２−ヒドロキシカルボン酸エステルおよび混合エステル を提供する。 【解決手段】 一般式（Ｉ） ［式中、ｃｅｌｌ−Ｏは、セルロース鎖上に存在するヒ ドロキシル基の置換残基を表し、Ｂは、下記式（ＩＩ Ｉ） −（Ｅ−Ｏ） n − （ＩＩＩ） （Ｅは、Ｃ原子を２から４個有する脂肪族の分枝もしく は未分枝鎖を表し、ｎは１から５の整数である）で表さ れるポリマー状エーテル基であり、ｎが０に等しい場合 には基Ａの少なくとも１つは、メチル、エチル、ベンジ ル、カルボキシアルキル、スルホアルキルまたはシアノ エチル基であり、基Ａの少なくとも１つは、下記式（Ｉ Ｉ） （式中、Ｄ 1 およびＤ 2 は、互いに独立して、水素原子ま たはメチルもしくはエチル基を表し、ｍは１から１０の 整数を表す）で表される２−ヒドロキシカルボン酸であ る］で表される熱可塑性セルロースエーテルエステル 類。

Low molecular weight carboxyalkylcellulose esters and their use as low viscosity binders and modifiers in coating compositions

Carboxyalkylcellulose esters are disclosed having relatively low degrees of polymerization. These new carboxyalkylcellulose esters include carboxymethylcellulose acetate, carboxymethylcellulose acetate propionate, and carboxymethylcellulose acetate butyrate. The inventive esters exhibit solubility in a range of organic solvents, and are useful in coatings and ink compositions as binder resins and rheology modifiers.

一种熔融纤维素混合酯的制备方法及纤维素混合酯及纤维及薄膜

本发明公开了一种熔融纤维素混合酯的制备方法，属于纤维领域，步骤如下：获得纤维素原料，将纤维素原料溶解于溶剂当中，所述的溶剂含有OAc‑、HCOO‑、Cl‑、(Me O)2PO2‑中的一种或多种，获得溶液；在上述溶液当中添加有机物单体，反应获得第一反应物A；在第一反应物A添加低聚物B，反应得到纤维素混合酯，所述的低聚物B同时含有‑OH和‑COOH；本发明还公开了一种纤维或薄膜，其特征在于，制备方法如下：制备纤维素混合酯，将纤维素混合酯加热熔融，牵伸获得纤维或薄膜。

Preparation of degradable copolymers

A preparation process of a degradable copolymer comprising carrying out dehydration polycondensation of polysaccharide (A) with one or more compounds (B) selected from the group consisting of: (b1) hydroxycarboxylic acid, (b2) polyhydroxycarboxylic acid, (b3) aliphatic polyhydric alcohol and aliphatic polybasic acid, and (b4) aliphatic polyester derived from aliphatic polyhydric alcohol and aliphatic polybasic acid. A copolymer having a high molecular weight, excellent toughness, transparency and heat resistance, and additionally having a high melt tension can be obtained with a reaction time less than a half of the conventional process. The copolymer obtained by the invention is a material suited for injection molding, extrusion, calendaring, blow forming, balloon forming, vacuum forming and foaming. Particularly, the copolymer obtained by the invention has a high melt tension and thus the molten copolymer is difficult to sag and flow and can be processed with ease into foams and blow bottles.

The water-soluble esterified cellulose ether

1. i) R이 2가 탄화수소 기인, 식 - C(O) - R - COOH의 기 또는 지방족 1가 아실 기와 식 -C(O) - R - COOH의 기의 조합을 포함하고, ii) 최대 70,000 달톤의 중량 평균 분자량 M w 를 갖고, iii) 0.4 이하의 - C(O) - R - COOH 기의 중화도를 갖고, 그리고 iv) 2℃에서 적어도 2.0 중량 퍼센트의 물에서 용해도를 가지며, 장용성 캡슐을 제조하는데 유용한 에스테르화된 셀룰로오스 에테르.

Pharmaceutical compositions with enhanced performance and improved processability

본원에 개시되고 청구된 발명의 개념(들)은 약물 성능을 증진시키고 가공성을 개선시키기 위한 중합체에 관한 것이다. 구체적으로, 상기 중합체는 히드록시프로필 메틸 셀룰로스 아세테이트 숙시네이트 (HPMC-AS)를 포함한다. HPMC-AS 상에서, 숙시노일의 총 치환도의 백분율은 C6-OH 위치에서 12% 미만이고 C3-OH에서 53% 초과이고, 아세틸의 총 치환도의 백분율은 C6-OH 위치에서 32% 초과이다.

Usage of carboxymethyl cellulose acetate butyrate

一种用于改善在涂层纤维素基材(例如人造纤维板)上的固着性的方法。所述方法包括以下步骤：将含水的羧甲基纤维素乙酸酯丁酸酯胶料组合物施用到人造纤维基材上，形成施胶的基材。然后干燥施胶的基材。接下来，施用含水的涂料组合物，形成涂层的施胶基材。然后干燥涂层的施胶基材。根据本发明，用于所述方法的含水羧甲基纤维素乙酸酯丁酸酯胶料组合物含有羧甲基纤维素乙酸酯丁酸酯、水和有机溶剂。本发明也涉及一种施胶的人造纤维基材，其含有人造纤维基材和羧甲基纤维素乙酸酯丁酸酯胶料。所述羧甲基纤维素乙酸酯丁酸酯可以是内施胶剂或者外施胶剂。

Hypromellose acetate succinate and preparation method thereof

提供了具有如下性质的HPMCAS(乙酸琥珀酸羟丙醛纤维素)：所述HPMCAS溶于溶剂中的溶液具有受控粘度，还提供了所述HPMCAS的制备方法。更具体地，提供了具有如下性质的HPMCAS：10重量份的所述HPMCAS溶于100重量份的二氯甲烷与甲醇的重量比为1:1的混合溶剂中的溶液在20℃的粘度为135mPa·s以下，还提供了所述HPMCAS制备方法，该方法包括：在乙酸钠存在下，将乙酸酐和琥珀酸酐加入到羟丙甲纤维素溶于冰醋酸中的溶液中以获得反应产物混合物的酯化步骤，其中间歇地加入所述琥珀酸酐；以及将反应产物混合物与水混合以沉淀出所述HPMCAS的沉淀步骤。

Aqueous composition comprising dispersed esterified cellulose ether

An aqueous composition which is useful for producing coatings and capsule shells comprises a) dispersed particles of an esterified cellulose ether comprising (i) groups of the formula —C(O)—R—COOA or (ii) a combination of aliphatic monovalent acyl groups and groups of the formula —C(O)—R—COOA, wherein R is a divalent hydrocarbon group and A is hydrogen or a cation, and the total degree of ester substitution is more than 0.70, and b) an esterified cellulose ether comprising aliphatic monovalent acyl groups and groups of the formula —C(O)—R—COOH, R being a divalent hydrocarbon group, wherein I) the degree of neutralization of the groups —C(O)—R—COOH is not more than 0.4, II) the total degree of ester substitution is from 0.03 to 0.70, and III) the esterified cellulose ether b) has a solubility in water of at least 2.0 weight percent at 2° C.

Pharmaceutical composition having enhanced performance and improved processability

Method of preparing hydroxypropyl methylcellulose acetate succinate particle with controlled particle size distribution, and HPMCAS powder prepared thereby

히드록시프로필 메틸셀룰로오스 아세테이트 숙시네이트(HPMCAS) 입자의 제조방법 및 히드록시프로필 메틸셀룰로오스 아세테이트 숙시네이트(HPMCAS) 입자가 개시된다. 개시된 히드록시프로필 메틸셀룰로오스 아세테이트 숙시네이트(HPMCAS) 입자의 제조방법은 촉매의 존재하에 반응매질 내에서 히드록시프로필 메틸셀룰로오스(HPMC), 아세트산 무수물 및 숙신산 무수물을 에스테르화 반응시켜 히드록시프로필 메틸셀룰로오스 아세테이트 숙시네이트(HPMCAS)를 포함하는 반응액을 얻는 단계(에스테르 반응단계), 및 상기 반응액을 물에 연속적 또는 간헐적으로 투입하여 입자를 생성시키는 단계(입자화 단계)를 포함한다. Disclosed are a process for preparing hydroxypropyl methylcellulose acetate succinate (HPMCAS) particles and hydroxypropyl methylcellulose acetate succinate (HPMCAS) particles. The disclosed method for preparing hydroxypropyl methylcellulose acetate succinate (HPMCAS) particles comprises esterifying hydroxypropyl methylcellulose (HPMC), acetic anhydride and succinic anhydride in a reaction medium in the presence of a catalyst to hydroxypropyl methylcellulose acetate. It includes a step of obtaining a reaction solution containing succinate (HPMCAS) (ester reaction step), and the step of continuously or intermittently adding the reaction solution to water to generate particles (particulate step).

Methods and compositions for weight management and blood glucose management

Thermoplastic cellulose ether ester copolymers and process for their preparation

For the cellulose based nano particle that medicine delivers

一方面，本发明提供了包含共价连接于至少一种聚(乙二醇)（PEG）和至少一种疏水药物的乙酰化羧甲基纤维素（CMC-Ac）的化合物。在另一方面，提供了包含这类化合物的自组装纳米粒子组合物。

METHODS AND COMPOSITIONS FOR WEIGHT CONTROL AND FOR IMPROVEMENT OF GLYCEMIC CONTROL

1. Модифицированный пищевой продукт или продукт питания, содержащий пригодный в пищу полимерный гидрогель.2. Модифицированный пищевой продукт или продукт питания по п. 1, отличающийся тем, что указанный пригодный в пищу полимерный гидрогель имеет коэффициент набухания 40 или больше.3. Модифицированный пищевой продукт или продукт питания по п. 1, отличающийся тем, что указанный пригодный в пищу полимерный гидрогель имеет коэффициент набухания 80 или больше.4. Модифицированный пищевой продукт или продукт питания по п. 1, отличающийся тем, что указанный пригодный в пищу полимерный гидрогель имеет модуль упругости не менее 200 Па.5. Модифицированный пищевой продукт или продукт питания по п. 1, отличающийся тем, что указанный пригодный в пищу полимерный гидрогель имеет вязкость не менее 15 s.6. Модифицированный пищевой продукт или продукт питания по п. 1, отличающийся тем, что пищевой продукт или продукт питания содержит углеводы, а указанный пригодный в пищу полимерный гидрогель заменяет по крайней мере часть углеводного содержимого по отношению к соответствующему обыкновенному пищевому продукту или продукту питания.7. Модифицированный пищевой продукт или продукт питания по п. 6, отличающийся тем, что указанный пищевой продукт или продукт питания содержит углеводы из зерна, хлебных злаков или крахмалистых овощей.8. Модифицированная мука, содержащая пригодный в пищу полимерный гидрогель, выбранный из пригодных в пищу полимерных гидрогелей, сформированных поперечной сшивкой гидрофильного полимера поликарбоксильной кислотой и пригодных в пищу полимерных гидрогелей.9. Модифицированная мука по п. 8, отличающаяся тем, что ука РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 2014 110 522 A (51) МПК A23L 1/05 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ЗАЯВКА НА ИЗОБРЕТЕНИЕ (21)(22) Заявка: 2014110522/13, 19.03.2014 (71) Заявитель(и): УАН С.Р.Л. (IT), ДЖЕЛЕЗИС АйПи, ЛПи (US) Приоритет(ы): (30) Конвенционный приоритет: (72) Автор(ы): САННИНО Алессандро (IT), ...

Cellulose ether-esters and process

Acetylated cellulose ether and articles comprising the same

아세틸화 셀룰로오스 에테르 및 이를 포함하는 물품이 개시된다. 개시된 아세틸화 셀룰로오스 에테르는, 1~2의 알킬기 치환도(DS), 0~1의 히드록시알킬기 치환도(MS) 및 1~2의 아세틸기 치환도(DS)를 갖는다.

Esterified cellulose ethers having a specific substituent distribution

에스테르화된 셀룰로즈 에테르는, (i) 지방족 1가 아실 그룹 또는 (ii) 화학식 -C(O)-R-COOA의 그룹(여기서, R은 2가 지방족 또는 방향족 탄화수소 그룹이고, A는 수소 또는 양이온이다) 또는 (iii) 지방족 1가 아실 그룹과 화학식 -C(O)-R-COOA의 그룹의 배합물을 포함하며, 상기 셀룰로즈 에테르는, 1 내지 4개의 결합에 의해 연결된 무수글루코스 단위들을 갖고 또한 치환체들로서 메틸 그룹, 하이드록시알킬 그룹, 및 임의로 메틸과는 상이한 알킬 그룹을 가지며, 이때 상기 에스테르화된 셀룰로즈 에테르는 0.05 내지 1.00의 MS(하이드록시알킬)를 갖게 되고, 무수글루코스 단위들의 하이드록실 그룹들은, [s23/s26 - 0.2*MS(하이드록시알킬)] (여기서, s23은 상기 무수글루코스 단위의 2- 및 3-위치의 단지 2개의 하이드록실 그룹들만이 메틸 그룹으로 치환되는 무수글루코스 단위들의 몰 분율이고, s26은 상기 무수글루코스 단위의 2- 및 6-위치의 단지 2개의 하이드록실 그룹들만이 메틸 그룹으로 치환되는 무수글루코스 단위들의 몰 분율이다) 이 0.36 이하이도록, 메틸 그룹들로 치환되게 된다. 에스테르화된 셀룰로즈 에테르는 수난용성 약물용 부형제로서 유용하다.

Ester compound of cellulose derivative and manufacturing method for same

本发明提供制造聚合度降低受到抑制的纤维素衍生物的酯化物的方法，以及通过该制造方法获得的成型加工时的热流动性、色调优异的纤维素衍生物的酯化物。一种纤维素衍生物的酯化物的制造方法，其特征在于，是在包含离子液体、纤维素衍生物、酯化剂的混合物中，将纤维素衍生物酯化来制造纤维素衍生物的酯化物的方法，其使用选自羧酸酐、羧酸卤化物、羧酸中的至少1种酯化剂。

Mixed esters of hydroxyalkyl celluloses

The invention relates to liquid crystalline or cholesteric mixed esters of a) hydroxyalkyl ethers of cellulose with b) saturated aliphatic or aromatic carboxylic acids and c) unsaturated mono- or dicarboxylic acids. The invention also relates to polymers obtained by radiation curing of the inventive mixed esters and to coating compounds, especially lacquers, containing the inventive mixed esters or pigments.

Effect paint or effect paint, in particular for vehicle bodies, using liquid-crystalline interference pigments

Cellulose derivative and process for production thereof, cellulose resin composition, molded article and method for production thereof, and housing for electrochemical device

Disclosed is a cellulose derivative having good thermal plasticity, strength and heat resistance and suitable for molding. In the cellulose derivative, at least a part of hydrogen atoms in hydroxy groups contained in the cellulose moiety is substituted by a hydrocarbon group having 1 to 7 carbon atoms and an aliphatic acyl group having 4 to 11 carbon atoms.

Cellulose derivative, thermoforming material, molded body, method for producing the same, and casing for electric and electronic equipment

Pharmaceutical compositions with enhanced performance comprising a hpmca polymer

Disclosed are polymers of hydroxypropyl methyl cellulose acetate succinate (HPMCAS) and hydroxypropyl methyl cellulose acetate (HPMCA) with unique degrees of substitution of hydroxypropoxy, methoxy, acetyl, and succinoyl groups. When used in making compositions comprising a low-solubility drug and such polymers, the polymers provide enhanced aqueous concentrations and/or improved physical stability.

Hydroxypropyl methylcellulose acetate succinate with improved substitution of acetate and succinate

Novel esterified cellulose ethers of high molecular weight and homogeneity

Esterified cellulose ethers which have i) a combination of aliphatic monovalent acyl groups and groups of the formula - C(O) - R - COOA wherein R is a divalent aliphatic or aromatic hydrocarbon group and A is hydrogen or a cation, ii) a weight average molecular weight Mw of from 80,000 Dalton to 350,000 Dalton, iii) a Polydispersity Mw/Mn of from 1.3 to 4.1, and iv) a viscosity of up to 4.0 mPa s, measured as a 2.0 wt% solution of the esterified cellulose ether in 0.43 wt% aqueous NaOH at 20 °C, are useful as enteric polymers for pharmaceutical dosage forms.

The method that the ester of cellulose ether is prepared in the presence of aliphatic carboxylic acid

在下述方法中制备各自具有相同醚和酯取代基但是具有不同重均分子量的两种或更多种纤维素醚的酯，所述方法包括以下步骤：在两个或更多个单独的反应中将纤维素醚用(i)脂族单羧酸酐或(ii)二羧酸酐或(iii)脂族单羧酸酐和二羧酸酐的组合在作为反应稀释剂的脂族羧酸的存在下酯化，其中在每个反应中，不同的摩尔比[脂族羧酸/纤维素醚的脱水葡萄糖单元]用于制备具有不同重均分子量的纤维素醚的酯。

The pharmaceutical composition of performance and improved processability with enhancing

本文公开和要求保护的发明构思涉及用于增强药物性能和改善加工性的聚合物。具体地，所述聚合物包含醋酸羟丙基甲基纤维素琥珀酸酯(HPMC‑AS)。在所述HPMC‑AS上，琥珀酰基总取代度的百分比在C6‑OH位置小于12％并且在C3‑OH位置大于53％，并且乙酰基总取代度的百分比在C6‑OH位置大于32％。

esterified cellulose ether, composition, solid dispersion, dosage form and capsule shell

resumo “éter de celulose esterificado, composição, dispersão sólida, forma de dosagem e invólucro de cápsula” éteres de celulose esterificados compreendendo (i) grupos da fórmula –c(o)-r-cooa ou (ii) uma combinação de grupos acila alifáticos monovalentes e grupos da fórmula –c(o)-r-cooa, onde r é um grupo hidrocarboneto alifático ou aromático divalente e a é hidrogênio ou um cátion, que tem uma viscosidade de até 50 mpa.s, medida como uma solução de 10% em peso do éter de celulose esterificado em acetona a 20ºc, e um peso molecular médio ponderal mw de pelo menos 220.000 daltons e uma viscosidade de até 100 mpa.s, medida como solução de 10% em peso do éter de celulose esterificado em acetona a 20ºc, e um peso molecular médio ponderal mw de pelo menos 310.000 daltons são úteis no preparo de fármacos compreendendo dispersões sólidas. "esterified cellulose ether, composition, solid dispersion, dosage form and capsule shell" esterified cellulose ethers comprising (i) groups of the formula -c (o) -r-cooa or (ii) a combination of aliphatic acyl groups monovalent groups and groups of the formula -c (o) -r-cooa, where r is a divalent aliphatic or aromatic hydrocarbon group and a is hydrogen or a cation, which has a viscosity of up to 50 mpa.s, measured as a solution of 10 % by weight of acetone esterified cellulose ether at 20 ° C, and a weight average molecular weight mw of at least 220,000 daltons and a viscosity of up to 100 mpa.s measured as a 10% by weight solution of acetone esterified cellulose ether at 20 ° C, and a weight average molecular weight mw of at least 310,000 daltons are useful in the preparation of drugs comprising solid dispersions.

New esterified cellulose ether with extremely low viscosity

Use of special screens in the preparation of cellulose powder

The present invention refers to the use of screens comprising at least two layers of different mesh or pore size in a cellulose powder preparation method as well as to said method, wherein grinding the cellulose pulp and sieving the obtained particles can be carried out on-line.

Dispersion comprising an esterified cellulose ether

하기를 포함하는 캡슐 쉘 제조에 유용한 수성 조성물: a) (i) 화학식 -C(O)-R-COOA의 기 또는 (ii) 지방족 1가 아실기와 화학식 -C(O)-R-COOA(식 중, R은 2가 지방족 또는 방향족 탄화수소기이고, A는 수소 또는 양이온이다)의 조합을 포함하는 적어도 1종의 분산 에스테르화된 셀룰로오스 에테르, 및 b) 상기 분산 에스테르화된 셀룰로오스 에테르의 중량을 기준으로 하여, 0.05 내지 20%의 적어도 1종의 지방산의 염(여기에서 상기 분산 에스테르화된 셀룰로오스 에테르 입자의 중위 입자 크기(d50)는 최대 7 마이크로미터이고, 상기 중위 입자 크기(d50)는 상기 입자의 50 질량%가 소형 등가 직경을 갖고 50 질량%가 대형 등가 직경을 갖는 크기이다) Aqueous compositions useful for preparing capsule shells comprising: a) (i) a group of the formula -C(O)-R-COOA or (ii) an aliphatic monovalent acyl group with the formula -C(O)-R-COOA wherein R is a divalent aliphatic or aromatic hydrocarbon group, and A is hydrogen or a cation) at least one dispersion esterified cellulose ether, and b) based on the weight of the dispersion esterified cellulose ether wherein 0.05 to 20% of a salt of at least one fatty acid, wherein the median particle size (d50) of the dispersed esterified cellulose ether particles is at most 7 micrometers, and the median particle size (d50) is the particle size 50% by mass of has a small equivalent diameter and 50% by mass has a large equivalent diameter)

Hydroxypropyl methylcellulose phthalate particles and their production method

Preparation method of high oil-absorption hemp cellulose

本发明公开了一种高吸油麻纤维素的制备方法，属于吸油材料制备技术领域，其特征在于，包括以下步骤：配制处理液→浸渍处理液→脱水→预烘→焙烘→水洗→烘干，本发明通过合理配置及浸渍处理液，以及采用预烘→焙烘→水洗→烘干工艺，有效的提高和保持产品的疏水亲油性能。本发明工艺简单、流程短，制取的高吸油麻纤维素油水选择性好，吸附速度快，吸油量大，可生物降解。

Soluble ester cellulose ether with low degree of neutralization

一种包含脂肪族单价酰基和式‑C(O)‑R‑COOH的基团的酯化纤维素醚，R是二价烃基，所述酯化纤维素醚具有以下性质：i)所述基团‑C(O)‑R‑COOH的中和度不大于0.4，ii)总酯取代度是0.10到0.70，以及iii)所述酯化纤维素醚在2C下在水中的溶解度是至少2.0重量％。

Optical film, circularly polarizing plate and organic electroluminescent display device

Provided is an optical film containing a cellulose derivative, the optical film having an in-plane retardation Ro 550 within the range of 120 to 160 nm measured at a wavelength of 550 nm under an atmosphere of a temperature of 23° C. and a relative humidity of 55%, and a ratio Ro 450 /Ro 550 within the range of 0.65 to 0.99, Ro 450 /Ro 550 being a ratio of an in-plane retardation Ro 450 measured at a wavelength of 450 nm to the in-plane retardation Ro 550 measured at a wavelength of 550 nm, wherein, a substituent of a glucose skeleton in the cellulose derivative satisfies the requirements (a) and (b) which are described in the specification, and the optical film contains a compound A satisfying the following condition defined by Expression (a1) which is described in the specification.