СПОСОБ ПОЛУЧЕНИЯ ГИДРОГЕЛЕЙ, ХАРАКТЕРИЗУЮЩИХСЯ СОЧЕТАНИЕМ ВЫСОКОГО МОДУЛЯ УПРУГОСТИ И ВЫСОКОЙ АБСОРБЦИОННОЙ СПОСОБНОСТИ

Изобретение дополнительно относится к способам получения поперечно-сшитой карбоксиметилцеллюлозы, композициям, содержащим поперечно-сшитую карбоксиметилцеллюлозу, и способам применения поперечно-сшитой карбоксиметилцеллюлозы, например, для лечения избыточной массы тела или ожирения или для усиления гликемического контроля. Описана карбоксиметилцеллюлоза, поперечно-сшитая лимонной кислотой, для снижения потребления калорий, снижения массы тела, лечения ожирения, усиления гликемического контроля, лечения или профилактики диабета и/или для применения в качестве абсорбирующего материала, полученная способом, включающим поперечное сшивание карбоксиметилцеллюлозы лимонной кислотой, где вязкость указанной карбоксиметилцеллюлозы в виде 1% (мас./мас.) водного раствора при 25°С составляет более 6000 сП и индекс полидисперсности составляет менее 8. Также предложены способ получения поперечно-сшитой карбоксиметилцеллюлозы, поперечно-сшитая карбоксиметилцеллюлоза, фармацевтическая композиция, содержащая ...

ПРОИЗВОДНЫЕ ЦЕЛЛЮЛОЗЫ

Изобретение относится к способам получения дериватизированной целлюлозы и к дериватизированным целлюлозным продуктам, полученным с использованием указанных способов. Способ дериватизации целлюлозной волокнистой массы включает приготовление реакционной среды, содержащей мочевину и дериватизирующий реагент, не являющийся сульфаминовой кислотой. Затем проводят реакцию химической дериватизации между дериватизирующим реагентом и целлюлозной волокнистой массой в реакционной системе, имеющей содержание воды 0-20 мас.%. Причем целлюлозная волокнистая масса является волокнистой массой из твердой древесины, волокнистой массой из мягкой древесины или растворимой волокнистой массой. Далее проводят необязательную очистку и выделение дериватизированного целлюлозного продукта. Обеспечивается дериватизация целлюлозной волокнистой массы при высоком содержании твердых веществ или даже в абсолютно сухом состоянии без предварительной обработки целлюлозы. 4 н. и 23 з.п. ф-лы, 4 ил., 4 табл., 7 пр.

СПОСОБ ПОЛУЧЕНИЯ ЦЕЛЛЮЛОЗНЫХ ТОНКИХ ВОЛОКОН

Изобретение относится к способу получения целлюлозных тонких волокон. Описан способ получения поверхностно-модифицированных целлюлозных тонких волокон, включающий импрегнирование целлюлозы реакционно-модифицирующим фибриллирующим раствором, который получен добавлением реагента для модифицирования целлюлозы к муравьиной кислоте, или высококонцентрированным водным раствором муравьиной кислоты для фибрилляции целлюлозы, где реагент для модифицирования целлюлозы включает соединение по меньшей мере одного вида, выбранное из галогенангидрида карбоновой кислоты, ангидрида карбоновой кислоты, карбоновой кислоты, изоцианата и эпоксида. Также описан вариант способа получения поверхностно-модифицированных целлюлозных тонких волокон. Технический результат: повышение степени кристалличности и снижение чувствительности к повреждению формы. 2 н.п. ф-лы, 1 табл., 6 пр., 6 ил.

ТОНКОЕ ЦЕЛЛЮЛОЗНОЕ ВОЛОКНО И СПОСОБ ЕГО ПОЛУЧЕНИЯ

Изобретение относится к тонкому целлюлозному волокну, которое может быть использовано в разнообразных композитных материалах и покровных агентах, и также может быть применено для формирования листа или пленки. Способ получения тонких целлюлозных волокон включает импрегнирование целлюлозы фибриллирующим раствором, содержащим полярный апротонный растворитель и виниловый сложный эфир карбоновой кислоты или альдегид для фибрилляции целлюлозы. Причем полярный апротонный растворитель имеет донорное число 26 или более. Содержание винилового сложного эфира карбоновой кислоты или альдегида составляет 0,05-50 вес.% относительно всего количества фибриллирующего раствора. Обеспечивается энергосберегающий способ получения тонких целлюлозных волокон, которые являются наноразмерными, имеют высокую степень кристалличности и менее уязвимы к повреждению формы волокон. 2 н. и 11 з.п. ф-лы, 15 ил., 2 табл., 28 пр.

Частичный сложный эфир азотистой карбоновой кислоты с целлюлозой и способ его получени

... 1. Частичный сложный эфир азотистой карбоновой кислоты с целлюлозой или его соль (при условии исключения случая, когда азотистой карбоновой кислотой является глицин, аланин, аминоэнантовая кислота, аминокапроновая кислота и п-аминобензойная кислота), причем указанный частичный сложный эфир содержит в молекулярной цепи, по меньшей мере, одно звено глюкозы, представленное следующей общей формулой (I) в которой А1, А2 и А3 независимо друг от друга означают атом водорода или азотистую ацильную группу, представленную общей формулой (II), при условии, что все радикалы А1, А2 и А3 не являются атомами водорода в которой R2 означает атом водорода, алкильную группу, содержащую 1~6 атомов углерода, аминогруппу или протонированную аминогруппу, R3 означает атом водорода, алкильную группу, содержащую 1~6 атомов углерода, или арильную группу, R4 означает атом водорода, алкильную группу, содержащую 1~4 атомов углерода, гидроксильную группу, меркаптогруппу или азотистый заместитель, представленный общими ...

СПОСОБ ПОЛУЧЕНИЯ ГИДРОГЕЛЕЙ, ХАРАКТЕРИЗУЮЩИХСЯ СОЧЕТАНИЕМ ВЫСОКОГО МОДУЛЯ УПРУГОСТИ И ВЫСОКОЙ АБСОРБЦИОННОЙ СПОСОБНОСТИ

СПОСОБ НЕПРЕРЫВНОГО АЦЕТИЛИРОВАНИЯ ЭЛЕМЕНТОВ ИЗ ДРЕВЕСИНЫ

СТОМАТОЛОГИЧЕСКИЙ МАТЕРИАЛ

METHOD OF CELLULOSE SHEET MATERIAL ACTIVATION

Verfahren zur Darstellung korkaehnlicher Massen

Verfahren zur Acylierung von Cellulose unter Erhaltung der Faserstruktur

DURCH BESTRAHLUNG HAERTBARER CELLULOSELACK.

Verfahren zur Veresterung von Cellulose

Acetylation process for cellulose-containing material, and process for production of modified wood

Acetylating agent vapour is brought into contact with a material containing cellulose with continuous agitation of the acetylating agent, the cellulose-containing material being acetylated in a vapour phase. Solvents for the dilution, catalysts and process of immersion (dipping) into an acetylating agent (liquid) are unnecessary; it is therefore not only the case that the process is simplified, but also that the acetylating period is shortened as a consequence of the increase in the reaction efficiency and the accumulation of excess heat of reaction in the cellulose-containing material during the reaction is prevented, thus improving the acetylation uniformity. The invention proposes acetylating wood strips by this process, where these are accumulated and modified wood is produced. This modified wood has a superior resistance to moisture and does not have an acetic acid odour, nor does it cause any rusting processes.

COPOLYMERE UND DIESE ENTHALTENDE ÖL- UND WASSERABWEISENDE ZUSAMMENSETZUNGEN

CELLULOSE-PFROPFPOLYMER

TEXTILWASCHMITTEL

Verfahren zur Veresterung von Cellulose

Verfahren zur Darstellung von Estem der polymeren Kohlenhydrate

Verfahren zum Ausfaellen von Celluloseestern aus ihren Loesungen

Verfahren zur Herstellung von gebleichtem und gereinigtem Celluloseacetat

Intramolecular transesterification of material, especially plant extract, containing cyclic polyhydroxy compounds, e.g. to prepare bioactive natural products, carried out at elevated temperature and pressure

Intramolecular transesterification of starting materials containing cyclic polyhydroxy compounds (e.g. phenylethanoids) is carried out at a pressure of 1-20 x 103> Pascals and a temperature of 40-250[deg]C, using an autoclave, sealed glass tube, distillation apparatus, extractor (e.g. Soxhlet) or perforator as apparatus. ACTIVITY : Antiinflammatory. MECHANISM OF ACTION : None given in the source material.

VERFAHREN ZUR HERSTELLUNG GLYOXALBEHANDELTER HOCHMOLEKULARER SUBSTANZEN

Improvements in or relating to the preparation of arylaminosulphonate derivatives ofnatural and synthetic polymers

Arylamino sulphonate derivatives of natural or synthetic polymeric materials other than gelatin are made by adding an arylamino sulphonyl fluoride to a solution or suspension of the polymeric material, either in water or in an organic liquid, and which has a pH above 7 and stirring or agitating the mixture. Specified polymeric starting materials include carbohydrates or derivatives thereof containing free hydroxyl groups e.g. cellulose, starch, amylose and amylopectin and their derivatives, and synthetic polymers containing free hydroxyl and/or amino groups e.g. polyvinyl alcohol copolymers of vinyl alcohol with one or more ethylenically unsaturated copolymerizable monomers, e.g. vinyl acetate, polyvinylamine, polyvinylimine and polyethyleneimine. The starting material may be in the form of threads, fibres, fabric or film. Specified arylamino sulphonyl fluorides include o-, m-, and p-aminobenzene sulphonyl fluorides which may or may not be substituted in the benzene nucleus, e.g. by one ...

Acetylating wood so that it substantially maintains its stiffness during wetting

Wood which after being acetylated is less predisposed to becoming more flexible when wet. In particular the wood loses less than 10% of its stiffness as a result of wetting. Ideally the loss in stiffness is less than 8.6%. Preferably the wood is of commercial sizes, eg 0.02x0.02x1.5m to 0.3x0.16x4m. The weight of the wood at its geometric centre may increase by 14-22% due to the acetylating.

Dissolution and processing of cellulose

Improvements in the manufacture of yarns, fabrics, films and the like of organic esters of cellulose

Filaments, yarns, foils, films, and similar formed materials having a basis of an organic ester of cellulose are esterified with liquid media comprising anhydrides of lower fatty acids dissolved in diluents with the aid of perchloric acid as catalyst. Preferably, the materials have a basis of cellulose acetate and are esterified with acetic anhydride. The proportion of perchloric acid used is of the order of 0,1 to 0,2 per cent of the weight of the yarn. Diluents specified are benzene, xylene, tetra-and deca-hydronaphthalenes, kerosene, normal and iso butyl and amyl ethers, and carbon tetrachloride. Small proportions of swelling agents for the cellulose ester may be present, e.g. acetone, methylene ethylene ether, methylene dichloride, and acetic acid. The amount of acetic anhydride used for esterification is usually about 1 to 1\ba1/2\be times the weight of the material. The yarns used may be produced by the ordinary spinning process, or it may be a yarn which has been stretched, shrunk ...

Process for the manufacture of cellulose esters

Fully esterified cellulose esters made by treating cellulose material with a fatty acid or anhydride and an acid catalyst while retaining the fibrous state, are subjected to partial deesterification by dissolving them in a concentrated lower fatty acid containing a salt of a weak acid and heating, the reaction being terminated when the products have become soluble in acetone. The salt reacts with and neutralizes the residual catalyst. Sodium formate, acetate, borax, soap, and phenolates are specified salts. In addition to alkali or alkaline earth salts, salts of heavy metals may be used if sufficiently soluble. The hydrolysing acid may be formic, acetic, or propionic. It may be used in anhydrous state or it may contain some water. Mixtures of acids with each other, or with phenols or other solvents may be used. The temperature employed for the treatment may be 80--120 DEG C. The reaction may be stopped by lowering the temperature or pouring the solution into water or ether. The product ...

Process for the production of cellulose esters

For producing stabilized cellulose esters having an acyl content markedly lower than that of the triester, cellulose is esterified by the non-solvent method in the presence of a compound capable of supplying sulphuric acid radicles, and the content of sulphuric acid radicles, which determines the acyl content of the final ester, is controlled by adjustment of (a) the proportion between the quantity of esterifying agent and the quantity of compound capable of supplying sulphuric acid radicles, (b) the proportion between the quantity of compound capable of supplying sulphuric acid radicles and the quantity of cellulose and (c) the solvent power of the diluent preventing dissolution of the cellulose ester for the compound capable of supplying sulphuric acid radicles, and the removal of the sulphuric acid radicles from the intermediate mixed ester is effected with agents selected from those set forth in Specifications 411,260 and 468,880 which do not contain unesterified carboxylic radicles ...

Improvements in the production of cellulose derivatives

A process for the production of cellulose esters of increased acyl content comprises heating a mixture of a partially hydrolysed organic acid ester of cellulose and an organic acid anhydride dissolved in an organic solvent medium free from catalyst. The product is precipitated from solution in fibrous form and is relatively easily washed and dried. It possesses a degree of stability substantially greater than the hydrolysed cellulose ester from which it is prepared. The further esterification may be halted at any point short of the tri-ester. Esters which may be thus prepared include cellulose acetate, propionate, butyrate (including the triacetate, tri-propionate, tri-butyrate) and fully esterified mixed esters such as cellulose acetate-propionate, acetate-butyrate, acetate-stearate, acetate-laurate, acetate-crotonate and butyrate-crotonate. The hydrolysed ester (1 part by weight) may be dissolved in 3-10 parts by weight of organic acid and 0.1 to 2.0 parts of the anhydride added, depending ...

Process for working up molten cellulose derivatives into threads and other shaped articles

A cellulose derivative having a content of water between that which it would normally have after being exposed to the open air and that of the saturation point observed on melting is brought into the molten state and worked up into threads or other shaped structures. On exposure to the open air, cellulose triacetate takes up 0.1-0.3 per cent of water; a partially hydrolysed cellulose acetate may take up about 1.5 per cent. The saturation point observed on melting is that content of water above which evaporation of the water with foaming occurs when the cellulose derivative is melted. The presence of water in the cellulose derivative considerably reduces the melting-point and thus the temperature of the working-up process. The upper limit of the moisture content is usually not more than 10 per cent. For cellulose triacetate it is about 6 per cent and for a hydrolysed cellulose acetate it may be 8-9 per cent. The cellulose derivative may be dried to the desired moisture content during the ...

Improved Process of Producing Dyed Cellulose Esters.

... 12,995. Borzykowski, B. June 3. Formates, acetates, propionates, and other carboxylates.-Dyed cellulose carboxylates, such as formates, acetates, and propionates, are produced by treating cellulose, or oxy- or hydrocellulose with suitable dyes in the acidylizing- mixture. Yarns, films, &c. are produced by squirting the solutions obtained into the usual precipitating-media such as water, alcohol, benzene, &c. The dyed cellulose esters are soluble in chloroform, acetone, dichlorethylene, &c.

Improvements in or relating to the manufacture of cellulose esters and to articles produced therefrom

... 308,323. Dreyfus, H. Sept. 13, 1927. Yarns &c., treating with liquids.- Cellulosic textile materials such as cotton, viscose silk, and other regenerated cellulose, materials, are subjected to the action of an acetylation or other esterification bath containing an organic acid anhydride, zinc chloride or other zinc halide, hydrochloric or other hydrohalide acid, and a diluent such as will prevent any change of form of the materiai treated. Specification 308,322 also is referred to.

Improvements in or relating to the manufacture of cellulose esters and of articles made therefrom

Cellulosic material is esterified by means of fatty acid anhydrides in the presence of a catalyst comprising a hydrohalide acid mixed with one or more halides of iron, manganese, cobalt, nickel, or copper, either or both of the components of the mixed catalyst being present in a proportion of under 2 per cent on the weight of the cellulose. As initial materials in the process are mentioned cotton, or other cellulose or near conversion products, wood pulps, &c. Fibres or fabrics of cotton, or viscose, or other regenerated cellulosic artificial fibres may also be employed. The starting material is preferably subjected to a pretreatment before the esterification, and the following are referred to as being particularly suitable: pretreatment with organic acids, as described, for example, in Specification 263,938, [Class 2 (ii), Cellulose &c.], pretreatment with hydrohalide acids, or halides of iron, tin, cobalt, nickel, manganese or copper, or mixtures thereof, as described in Specification ...

Manufacture of cellulose esters

... 329,704. Ellis, G. B., (Soc. des Usines Chimiques Rh¶ne-Poulenc). Feb. 25, 1929. Cellulose crotonates. - Cellulose crotonates, particularly those prepared by the process described in Specification 328,588, are subjected to a partial saponification in solution in a solvent or mixture of solvents containing water and preferably in the presence of saponification catalysts to give cellulose crotonates of different solubility. The process can either be applied to a solution of a cellulose crotonate prepared from an already isolated tricrotonate or to the primary solution obtained by the crotonylation of cellulose. Suitable catalysts comprise those employed in the saponification of cellulose acetate or other cellulose esters, for example mineral acids, fatty or aromatic sulphonic acids, acid salts such as bisulphates, or zinc chloride. The catalyst employed for esterification may be used for saponificution or this may be either partly or completely neutralized and another catalyst added. Suitable ...

Improvements in the manufacture of esters of cellulose or of its transformation products or of other carbohydrates

A modification of the process described in the parent Specification for the esterification of cellulose, or of a transformation product thereof, or of another carbohydrate in the presence of liquid sulphur dioxide, consists in carrying out the reaction under an increased pressure above that due to the use of the liquid sulphur dioxide. The additional pressure may be obtained by the introduction of an inert gas such as compressed air or nitrogen, and a limited quantity of an oxidizing agent such as described in Specification 343,655, may be present if desired. In examples: (1) cotton linters are acetylated by means of acetic anhydride in liquid sulphur dioxide, the pressure being maintained at 12 atmospheres by the introduction of nitrogen; sulphuric acid is used as the catalyst. (2) lignocellulose is treated with a mixture of acetic anhydride, propionic acid, sulphur dioxide, and sulphuric acid under a pressure of 12 atmospheres produced by means of nitrogen, the product being cellulose ...

Improvements in the manufacture of cellulose derivatives

Cellulose acetates and other lower fatty acid esters of cellulose are produced by reacting on cellulose with a lower fatty acid in the presence of a relatively large proportion of esterification catalysts or condensing agents, preferably in a quantity by weight greater than the acetic acid &c. and in quantity considerably greater than the weight of the cellulose, for example, more than 4-8 times such weight. As the catalyst &c. may be used fairly concentrated sulphuric acid or similar acting substance, for example, sodium or potassium bisulphate or phosphoric acid, preferably sulphuric acid of more than 60 per cent concentration, for example, of 75 per cent concentration. Generally the acetic acid or other lower fatty acid is used in quantity theoretically larger than that required for esterification, in order to dissolve the ester as it is formed; but lower proportions of acetic acid may be employed, and the reaction carried out in the presence of a diluent such as benzene, ethyl ether ...

Manufacture of cellulose esters

Cellulose esters insoluble in the usual organic solvents are obtained by treating cellulose or a cellulose conversion product with an organic anhydride as acylating agent in presence of a catalyst in such manner that the structure of the parent material is retained, and the acylating mixture adhering to the product is removed by washing with an agent which does not react with the acylating agent but which is a solvent for both the catalyst and the acylating agent, and then removing the adherent washing agent by distillation. The process avoids the deleterious action of aqueous organic acids experienced when using water as washing agent, and facilitates recovery of the chemicals employed. As parent material for the production of the cellulose esters there may be used cotton, wood pulp, regenerated cellulose obtained from viscose ammoniacal copper oxide solution or quaternary ammonium salt solution, or denitrated nitrocellulose. The material may be loose or in the form of threads, skeins, ...

WAX-LIKE MATERIALS

Improvements in the manufacture of cellulose esters

Cellulose is esterified in the presence of a hydrohalide acid and a hydrohalide of a nitrogen containing base, and particularly mixtures of hydrochloric acid with ammonium chloride or the hydrochloride of an organic base. The organic bases used may be methylamine, ethylamine, propylamine, ethanolamine, or the corresponding dialkylamines, aniline, benzylamine, cyclohexylamine, or less advantageously, tertiary bases such as trimethylamine and pyridine. The amount of hydrohalide acid employed is preferably from 5-15 per cent based on the weight of the cellulose, and of the hydrohalide of the nitrogen containing base, up to 50 per cent. The cellulosic material, which may be pretreated, e.g. according to the process of Specification 263,938, 312,098, [both in Class 2 (ii), Cellulose &c.], or 342,739, is subjected to esterification either in solution, or in suspension in an indifferent liquid, or by the process of Specification 264,937, [Class 2 (ii), Cellulose &c.], in the absence of liquid ...

Process for the manufacture of cellulose esters

In the fibrous esterification of cellulose or cellulose derivatives containing free hydroxyl groups, esterification is carried out in a reaction mixture containing an ether of boiling point above 70 DEG C. as diluent. Such ethers include n-propyl, n-butyl, isobutyl, isoamyl, and n-amyl ethers. Catalysts such as perchloric acid, sulphuric acid and sulphuric-phosphoric acid may be present. The cellulose or cellulose derivative includes cotton linters, cotton fibre tissue paper, cotton, surgical cotton wool, sulphite wood pulp, hydrocellulose, reverted cellulose, and cellulose nitrates, acetates, formates or ethers. Substituted fatty acid anhydrides such as a chloracetic or an alkoxyacetic anhydride as in Specifications 287,880 and 313,408, [both in Class 2 (ii), Cellulose &c.], may be used with or instead of unsubstituted anhydride and substituted fatty acids such as chloracetic or alkoxyacetic acid may be used with or instead of unsubstituted acid in the esterification. In examples, cotton ...

Improvements in or relating to the manufacture of cellulose esters

In a process for stabilizing organic esters of cellulose, the esters immediately after precipitation from the esterification solution are mixed with water insoluble salts of a basic character. Advantageously, the ester after precipitation is suspended or dissolved in a liquid, e.g. a lower aliphatic acid, especially acetic acid or an aqueous solution thereof, the basic salt, finely powdered, or a soluble salt which may be converted to the basic salt being mixed in with the ester. Or the ester may be dissolved or suspended in an aqueous medium containing a salt which may yield the basic salt, by hydrolysis or by the action of a basic substance such as an alkali metal hydroxide or carbonate, e.g. sodium or potassium acetate, zinc chloride, aluminium chloride, tin chloride, lead chloride or mixtures of these. The temperature at which the basic salt is mixed with the cellulose ester depends on the method of formation of the basic salt. Elevated temperatures, e.g. the boiling point are usually ...

Improvements in or relating to the production of organic esters of cellulose

... 539,279. Cellulose esters. BRITISH CELANESE, Ltd. March 2, 1940, No. 3941. Convention date, March 4, 1939. [Class 2 (ii)] A primary esterification solution of a cellulose ester which has been prepared under conditions which lead to the presence of a proportion of sulphur compounds in the product is refined and stabilized by adding a polyhydric alcohol to the solution and allowing the mixture to stand until the desired solubility has been attained by the ester; a primary esterification solution is one in which the excess esterifying agent, e.g. anhydride, has been rendered ineffective by the addition of just sufficient of an appropriate reagent but before the catalyst has been neutralized. Preferably a mixture of the polyhydric alcohol, e.g. glycol or glycerine, with water is used, e.g. 1-6 parts by weight of glycerine with 2 parts by weight of water is added to a primary esterification solution which has been prepared in the presence of a substantial proportion of sulphuric acid and the ...

Improvements in the stabilisation of organic esters of cellulose

Organic acid esters of cellulose, e.g. cellulose acetate, propionate, butyrate, aceto-propionate and aceto-butyrate, are stabilised by subjecting them to the action of an aqueous solution of sulphuric acid containing a small proportion, based on the weight of the solution, of a wetting agent which is stable in the acid solution, while they are in suspension in said solution. Preferred wetting agents are the sodium salts of the sulphates of long chain secondary or branched chain alcohols, particularly the sulphates of 3 : 9-diethyl-6-tridecanol, 7-ethyl-2-methyl - 4 - undecanol and 2 - ethyl - 1 - hexanol. Other suitable wetting agents are turkey red oil, the sodium salts of alkyl benzene sulphonates in which the alkyl chain contains from 12 to 18 carbon atoms and the sodium salts of monobutyl-phenyl-phenol monosulphonate and dibutyl - phenyl - phenol disulphonate. The stabilising treatment may be effected at temperatures of from 18 DEG to 100 DEG C. Examples are given, in one of which acetone-soluble-cellulose ...

Process for the improvement of viscose textile materials by esterification

... 546,657. Esterifying cellulosic textile materials; dyeing processes. COTOPA, Ltd., and TRENCH, J. KNIGHTS-. Feb. 4, 1941, No. 1462. [Classes 2 (ii) and 15 (ii)] Fibres, or fabrics of regenerated cellulose from viscose are treated with an aqueous alkali solution, then with an aqueous lower aliphatic acid, i.e. an acid up to and including butyric acid, of not less than 90 per cent strength, and then with an esterifying medium containing the lower aliphatic acid, its anhydride, and a heavy metal halide as catalyst. The treatment increases the weight of the materials, renders fabrics resistant to shrinking and creasing, improves the wet tensile strength, and imparts a linen-like finish. Esterification may result in the production of cellulose acetates of 20-62.5 per cent combined acetic acid. The materials may be dyed before or after the esterification. Specified dyes which are suitable for dyeing before the esterification are substantive dyes such as Chloramine Fast Orange W.S., Solar Yellow ...

Process of Producing Cellulose Esters with more than Twenty per cent. Combined Fatty Acid.

... 75. Deutsche Gasgl³hlicht Akt.-Ges. Jan. 3,1914, [Convention date]. Carboxylates; hydrocellulose. - Cellulose esters with more than 20 per cent of combined fatty acid are prepared by treating hydracelluloses with the homologues of formic acid in the presence of catalysts and in the absence of fatty-acid anhydrides. It is preferred to use hydracellulose in a swollen condition. In examples, cellulose is kneaded with sulphuric acid, glacial acetic acid, and water, and a mixture of glacial acetic acid and sulphuric acid added, hydracellulose first precipitating and then going into solution as esterification proceeds; a further quantity of sulphuric acid and glacial acetic acid may be added after the hydracellulose has gone into solution; cotton-wool is dissolved in sulphuric acid, then precipitated water, and the swollen hydracellulose obtained treated with glacial acetic acid in which hydrochloric acid gas has been dissolved; filter paper is treated with soda-lye to form hydracellulose, which ...

Improvements in the manufacture and use of cellulose esters

Cellulose triesters of aliphatic acids containing 2-4 carbon atoms in the molecule, which have been made by a process of the suspension type, are ripened by forming a solution of the ester in a mixture of a lower aliphatic acid and a minor proportion of water or of an alcohol (especially a lower aliphatic alcohol, which is miscible with the acid in the proportion in which it is present, the mixture being substantially free from inorganic acids, and ripening the ester in the solution at a temperature above 100 DEG C. The triesters may be cellulose tripropionate, cellulose tributyrate and particularly cellulose triacetate, and mixed esters such as cellulose acetate-propionates and acetate-butyrates. Cellulose triacetate, for example, may be dissolved in hot aqueous acetic acid containing about 2-15 per cent. by weight of water, and ripened by maintaining the solution at a temperature above 110 DEG C., e.g. up to about 190 DEG -200 DEG C., particularly if the process is continuous. The concentration ...

Improvements in the manufacture of cellulose esters

Organic esters of cellulose are stabilized by passing hot water or a hot dilute aqueous medium continuously through the cellulose ester while maintaining the cellulose ester in a substantially stationary state. The cellulose ester may be an acetate, formate, propionate, or butyrate. Esters produced with the aid of sulphuric acid, zinc chloride, ferric chloride, hydrochloric acid, perchloric acid, zinc or magnesium perchlorate, phosphoric acid, sulphuryl chloride, or sodium bisulphite, as catalyst may be used. The cellulose ester may be treated in any form, but preferably in the form in which it is precipitated from esterification or ripening solutions. The precipitated ester may be washed or treated with weakly alkaline solutions prior to the stabilizing treatment. Sulphuric acid present in the material may be neutralized by addition of acetates, carbonates, or bicarbonates of sodium, potassium, or ammonium, but small amounts of free acid may be present during stabilization. Hot water or ...

Process for the saponification of cellulose esters

Cellulose esters or materials such as films, foils, fibres, filaments, threads, or fabrics composed of or containing cellulose esters are subjected to controlled saponification by treatment with a solution containing a mixture of an alkaline carbonate and boric acid. The progress of the saponification can be followed by estimation of the sodium salt, e.g. sodium acetate, formed in the course of the reaction. The quantity of sodium carbonate is calculated from the quantity of cellulose ester in the product to be treated and the degree of saponification required. To the calculated quantity there is added a further quantity of 2 grams per litre of the solution, since sodium carbonate in lower concentration than this does not exert any saponifying action. For cellulose acetate materials, the boric acid should not exceed 10 per cent of the cellulose ester and preferably it should be between 3 and 7 per cent. Mixed fabrics containing wool or natural silk together with cellulose ester fibres may ...

Improvements in the production of cellulose esters

Mixed cellulose esters are prepared by esterifying cellulose in the presence of an esterification catalyst with a mixture of the anhydrides of a saturated aliphatic acid and an unsaturated aliphatic acid, each of which acids contains at least four carbon atoms in the molecule. The conditions of esterification are such that the ester contains a relatively small proportion of unsaturated acid groups, about 0.2 to 0.3 per glucose residue. The most useful of these esters is cellulose butyrate crotonate, which may be moulded with or without a plasticiser at temperatures up to 200 DEG C., the moulded articles possessing both toughness and flexibility. Preferably, the catalyst is sulphuric acid, though phosphoric acid may be used, and only about 50-75 per cent of the catalyst should be present at the commencement of the reaction. The reaction temperature should not exceed 15 DEG C. The ester may be bleached prior to precipitation or following precipitation, in preference the bleaching being carried ...

Improvements in the production of cellulose esters of organic acids

A process for the production of stable primary organic acid esters of cellulose comprises reacting cellulose and an organic acid anhydride in the presence of an inorganic acid catalyst and of a solvent for the primary ester, neutralising the catalyst present and heating the solution of the ester while it still contains substantially no water until the ester has the required stability. Secondary esters of improved stability may also be produced by hydrolysing the stabilized primary esters with water. The catalyst is neutralized by the addition of magnesium, zinc, aluminium, calcium, barium or strontium acetate or barium or strontium oxide or hydroxide. Sodium salts should be avoided. The amount of water added with the neutralizing agent or that produced by neutralization should not be sufficient to hydrolyse the acid anhydride present, and if this anhydride is hydrolysed, more should be added to ensure an excess. The stabilization is carried out by heating at from 85 DEG to 130 DEG C. for ...

Improvements in or relating to preparation of cellulose acetate sorbate

Cellulose acetate sorbate having a total acyl degree of substitution (D.S.) of 2.2-2.9, the sorboyl D.S. being 0.01-0.35, is obtained by completely acylating cellulose, in the presence of a substantial amount of methylene chloride and a minimum effective catalytic amount of sulphuric acid, with an anhydride mixture of acetic and sorbic acids in which the sorbic acid amounts to 0.0023 to 0.13 mole. fraction of the organic acids and the anhydride value of the mixture amounts to at least 3 moles. anhydride per anhydroglucose unit, and partially hydrolysing the completely acylated cellulose by heating on the average at 50 DEG -55 DEG C., but not exceeding 65 DEG C., in the presence of 5-15 per cent (based on the weight of the cellulose) of either p-toluene sulphonic acid, benzene sulphonic acid, methane- or ethane-sulphonic acid or methionic acid as hydrolysis catalyst and with no more sulphuric acid than that used in the esterification step and in the presence of aqueous acetic acid containing ...

Water insoluble enzymes and method for preparing same

An enzymatically active, water-insoluble substance of the formula where "cell" designates a cellulose molecule, Z is an enzyme molecule, X is an -NH, -S-, imidazole or phenol group of the enzyme molecule and which is not essential to the enzymatic activity of the enzyme and n is an integer ar prepared by reacting the enzyme with a cellulose derivative cell-(-O-CO-CH2-Y)n where Y is a bromine or iodine atom. Specific examples relate to the formation of compounds comprising trypsin, chymotrypsin and ribonuclease.

Improvements in or relating to the manufacture of cellulose esters and to articles produced therefrom

... 308,322. Dreyfus, H. Sept. 13, 1927. Yarns &c., treating with liquids. - Cellulosic textile materials such as cotton, viscose silli, and other regenerated cellulose materials, are subjected to the action of an organic acid such as formic or acetic acid, and then to the action of an acetylation or other esterification bath containing fatty acid anhydride, zinc chloride or other zinc halide, hydrochloric or other hydrohalide acid, and a diluent such as will prevent any change of form of the material being treated.

Process for the manufacture of cellulose butyric esters

... 323,869. Ellis, G. B., (Soc. des Usines Chimiques Rhone-Poulenc). Nov. 20, 1928. Cellulose butyrates.-Butyric esters of cellulose, including both butyric or iso-butyric esters as well as mixtures thereof, are prepared by tueating cellulose or its near transformation products, for example hydrocellulose or oxycellulose, or wood cellulose with butyric anhydride in presence of sulphonic acids derived from aliphatic hydrocarbons, for example methane or ethane suphonic acids, and preferably in presence of a solvent for the ester obtained, for example butyric acid, benzene, or monoehloracetic acid. Other catalysts employed in the acetylation of cellulose, for example sulphuric acid or zinc chloride, may be combined with the sulphonic acids. Improved results are obtained when the cellulosic material is pretreated, for example with butyric acid with or without a catalyst, for example methane sulphonic acid. The cellulose butyrates are precipitated from solution, for example by water or alcohol.

Improvements in the manufacture of cellulose esters

... 313,408. Kodak, Ltd., (Assignees of Clarke, H. T., Malm, C. J., and Stinchfield, R. L.). March 28, 1927, [Convention date]. Divided on 287,880. Cellulose carboxylates, and processes for making filaments and films therefrom.-Cellulose esters of organic acids, other than the esters of the higher homologues of acetic acid, are prepared by treating cellulose, or a cellulose conversion product or derivative, with the organic acid in question in the presence of a substituted organic acid anhydride. The anhydride induces the esterification of the cellulose by the organic acid present, and this effect is the more noticeable in the case of substituted anhydrides not capable of esterifying cellulose. The anhydride of the organic acid may be used in place of the latter. Suitable substituted anhydrides are the halogen and alkyloxy derivatives of the acetic series, particularly such as contain less than 10 carbon atoms in the molecule, especially chloracetic anhydride. The organic acid used for esterification ...

Process of making cellulose acetate

To improve the condition of precipitated cellulose acetate an acetylating mixture is employed containing a liquid which boils above atmospheric temperature, is immiscible with the liquid precipitating-bath, and is inert to the acetylating agent, the mixture being introduced into the bath heated to a temperature at or above the boiling point of the volatile liquid. The volatile liquid is associated with a limited quantity of acetic acid. Ethylene chloride, chloroform, and trichlorethylene are suitable liquids. In an example, cotton fibre is pretreated with glacial acetic acid containing a mixed catalyst composed of sulphuric acid and orthophosphoric acids; excess of liquid is then removed by pressing or centrifuging to bring the ratio of acetic acid to cellulose approximately 1/1 , after which is added a mixture of acetic anhydride and ethylene chloride, and esterification effected at a temperature between 33-55 DEG C. The reaction mixture is introduced into a bath of water at a temperature ...

Process for producing bleached and purified cellulose acetate

... 1,139,616. Bleached and purified cellulose acetate. TEIJIN Ltd. 17 April, 1967, No. 17548/67. Heading C3A. Cellulose acetate in solution is treated with 0À005-5% of an oxidant, and subsequently while still in solution, or after having been precipitated, with 0À001-10% of a reducing agent, based on the weight of the cellulose acetate. Preferably, both treatments are effected in solution following neutralization of any strong acid used in the cellulose acetate preparation. Specified oxidants include alkali metal permanganates and chromates, hydrogen peroxide, organic peroxides, e.g. peracetic acid or dicumyl peroxide, and chlorites. Specified reducing agents include oxalic, formic, phosphorous and sulphurous acids and their alkali metal salts. The treatment improves purity, colour and heat resistance. In examples, cellulose di- or triacetate in conc. acetic acid solution which may contain methylene chloride and sodium acetate and sulphate, is treated, and the product is separated by precipitation ...

Improvements relating to forming mandrels

... 1,013,943. Mandrels for shaping plastic sheets. W. H. FOSTER & SONS Ltd., and D. FORSTER. Oct. 1, 1963 [Oct. 13, 1962], No. 38825/62. Heading B5A. [Also in Division H5] A forming mandrel for use in the apparatus described in Specification 1,013,942 is heated by a copper sheathed mineral insulated electric resistance cable 9.

A process and an apparatus for diluting an acetic acid solution of cellulose acetate with water

Continuously-operating apparatus for diluting an acetic acid solution of cellulose acetate with an aqueous solution of acetic acid, in order to obtain an easily washable product free from crumbs or powder, comprises a tank 1 through which partially diluted solution is recirculated by a pump 5, the solution re-entering the tank through an inlet 6 and flowing down a frustoconical wall 3 is a thin layer on to which the aqueous solution of acetic acid is directed by an atomizer 11 lying within a frusto-conical screen 2. Undiluted solution enters through an inlet 7 and diluted solution is removed through an outlet 8 by a pump 9, a liquid level being maintained above the fittings 7, 8. In an example described, 4000 kg./hours of acetic acid solution of cellulose acetate containing 12% cellulose acetate and 65.4% acetic acid are diluted with 1080 kg./hour of aqueous solution of 8% acetic acid to obtain a diluted solution of cellulose acetate containing 9.45% cellulose acetate ...

Graft polymer of cellulose and caprolactone

A graft polymer of cellulose has such a structure that all or some of the hydrogen atoms in the hydroxy groups have been substituted by a graft chain group of the formula: m being an integer of at least 1, and at least one of any balance of unreacted hydroxyl hydrogen atoms has been substituted by a group of the formula: n being an integer of at least 1 ...

Improvements in the production of cellulose derivatives

Cellulose is pretreated with a mixture of lower fatty acids, one of which is formic acid, containing a small proportion of a mineral acid catalyst, and the pretreated material is esterified by means of a fatty acid esterifying agent which is added in at least two stages. Cellulose acetate may be obtained by pretreating cellulosic material with a mixture containing formic acid, acetic acid, and sulphuric acid, and then after pretreatment, acetylating the cellulosic material in two stages with acetic anhydride. The pretreatment increases the reactivity of the cellulosic material, and the resulting cellulose acetate yields solutions and products of increased clarity. Propionic, or butyric acid may be used instead of acetic acid in the pretreatment. The formic acid may be used in an amount of 1-20 parts per 100 parts by weight of cellulose; the amount of sulphuric acid may be 0.5-2 parts; and the amount of glacial acetic acid may be 20-200 parts. The pretreatment mixture may be anhydrous or ...

Improvements in or relating to Means for Regulating the Gas Supply to Gas Fires.

... 21,376. Rasch, L. Sept. 22. Valves closing after predetermined interval or flow.-A valve device of the type opened by hand and closed by the fluid flow acting on a fan-wheel, and particularlv applicable for controlling the supply to gas-fires, is fitted with a fan-wheel of the type described in Specification 21,375/13, [Class 54, Gas distribution]. The valve r is opened by a cam - surface 6 on a member 4 secured to a plug cock 3 taking under the end of the valve spindle and under a pivoted member 2, which is adapted to move a cam m clear of a slot v. A further movement of the member causes a cam-surface 8 to engage a pin t on the spindle and to rotate the spindle, thus moving a pin s into the slot v, which holds the valve in the open position. To close the valve, the pin s is forced out of the slot v by the cam m, which has a pin-and-slot connexion with a disk rotated by the fan-wheel acting through two worms and worm-wheels.

CO-SOLVENT ACCELERATOR

Process of manufacture of cellulose esters

... 331,260. Hereward, H. W., and Hereward, P. O., (Representatives of Ehrhardt, E. F.), and Ellis, G. B., (Soc. des Usines Chimiques Rh¶ne-Poulenc). Dec. 31, 1928. Addition to 328,588. Cellulose aceto-crotonates; preparatory treatment of cellulose. - Cellulose or a near transformation product thereof is treated with crotonic anhydride in the presence of acetic acid and of a catalyst, with or without a solvent and with or without a diluent. Mixed esters of varying composition are obtained; according to examples di-aceto mono-crotonates and esters containing less than 10 per cent of combined acetic acid are prepared. When the acetic content is low the esters resemble the pure crotonates, being for example soluble in benzene and benzene-alcohol mixture; the esters with a high acetic content are insoluble in these solvents but may be soluble in acetone. The products may also be soluble in chloroform, acetic acid, ethyl acetate, and toluene. They give strong transparent films. As raw material cotton ...

Esters of cellulose containing organic acid radicles, are prepared in the presence of nitrogen dioxide or tetroxide, or of nitric oxide in conjunction with oxygen. An acylating agent containing dissolved nitrogen dioxide may be used. The nature of the products depends on the conditions. Thus, when cellulose, pretreated by one of the usual methods, is acetylated under normal conditions with acetic anhydride containing about 3 per cent of nitrogen dioxide, a chloroform-soluble ester free from nitrogen is obtained, which must be hydrolysed to render it soluble in acetone, e.g. by treatment with sodium bisulphate and dilute acetic acid. When, however, the acetic anhydride contains 4 per cent or more of nitrogen dioxide, esterification occurs in a relatively short time, and an acetone-soluble nitro-acetate is obtained directly; the ester is soluble also in chloroform, ethylene chloride, dioxane, and ethyl acetate. The nitrogen oxide may also be dissolved in other components of the reaction mixture ...

Manufacture of soluble cellulose esters of higher fatty acids

... 297,766. I. G. Farbenindustrie Akt.- Ges. Sept. 27, 1927. [Convention date]. Addition to 283,181. Cellulose esters of higher fatty acids.-The process of the parent Specification, according to which soluble cellulose esters of higher fatty acids are prepared by re-acting unpretreated cellulose with the chloride of a higher fatty acid in the presence of a base such as pyridine or quinoline and at a temperature above 100‹ C., with the optional addition of a diluent, is modified in that the re-action is first conducted at a temperature below 100‹ C. whereafter the esterification mixture, without isolation of the insoluble ester, is heated to a temperature above 100‹ C. until the desired solubility of the ester has been attained. In an example, untreated cellulose is heated with a mixture of lauryl chloride, pyridine, and chlorobenzene at 80-100‹ C. for 12-20 hours, whereafter the temperature is raised to 135-140‹ C. and is maintained in that range until the ester has become soluble. The mixture ...

Improved manufacture of organic cellulose ester moulding powders

A granular finely divided powder suitable for moulding purposes is prepared by dissolving an organic ester of cellulose in an inert solvent in the proportion of at least three parts by weight of solvent to one part of ester, and precipitating it by adding an organic precipitant. Any plasticizer may be added to the ester solution before precipitation. The mixture of solvent and precipitant may be removed from the precipitated ester by filtration or by evaporation. Organic esters specified are the acetate, acetate - propionate, propionate, butyrate, acetate - butyrate, and acetate - stearate. Examples of precipitants for cellulose acetate are benzene, toluene, xylene, carbon tetrachloride, methyl and ethyl alcohols, gasoline, kerosene, butane, propane, pentane, hexane, n-butyl alcohol, amyl acetate, trichlorethylene, butoxy-ethyl alcohol, and propylene chloride; for cellulose acetate - propionate there are mentioned carbon tetrachloride, toluene, trichlorethylene, butyl alcohol, iso-propyl ...

Improvements in or relating to setting control mechanism for calculating machines and cash registers

... 444,588. Calculating-apparatus ; accounting-machines. KRUPP AKT.-GES., F., Essen, Germany. Sept. 22, 1934, No. 27271. Convention date, Sept. 23, 1933. [Class 106 (i)] In order to check the accuracy of the initial setting of a calculating machine or cash register, a checking symbol is introduced into the machine by keys at the beginning of a calculation. If this symbol is not in agreement with a symbol formed automatically by the machine to correspond with the data set up, the operation of the machine is interrupted. Means are provided to print a checking symbol corresponding to the result of the operation or series of operations. The invention is described as applied to an accounting machine for dealing with series of transactions, each series comprising the entry of an old balance and one or more items, followed by the calculation of a new balance. The setting field, Fig. 3, comprises amount keys 10, account number keys 11, transaction banks 13, 14, debit and credit item keys 15, old balance ...

Improvements in the production of cellulose esters

To the primary acylation solution resulting from the esterification of cellulose in an excess of a lower fatty acid anhydride in a solvent for the ester, and in presence of a catalyst, ice is added to convert the excess of anhydride into the corresponding acid without substantially increasing the temperature of the solution, and the amount of ice added is sufficient to provide water for effecting conversion of the anhydride and hydrolysis of the cellulose ester. Preferably, the temperature is maintained not in excess of 30 DEG C. throughout the esterification of the cellulose and subsequent hydrolysis of the primary ester in solution. Sufficient ice may be added to reduce the concentration of the total organic acid to about 95 per cent with respect to water. The process may be applied to the production of cellulose acetate, propionate, butyrate, or aceto-butyrate. The cellulose may be cotton, cotton linters, wood pulp, or reconstituted cellulose. It may be activated by pretreatment with ...

Improvements in the production of cellulose esters

... 554,412. Cellulose esters. JONES, J. E. Dec. 30, 1941, No. 16765. [Class 2 (ii)] A cellulose primary organic ester is subjected to a ripening treatment while it is in solution in an acidic medium comprising water and an aromatic hydroxy compound which is a solvent for the primary ester. The cellulose ester may be obtained by treatment of cellulose with an organic acid anhydride in a liquid medium which is a solvent for the primary ester, and the ripening treatment may be carried out after the addition of water and an aromatic hydroxy compound. The process may be employed in the production of cellulose acetate, propionate, butyrate, and other organic esters of cellulose using sulphuric acid as catalyst e.g. 10-20 per cent. based on the weight of the cellulose. It may also be used in processes using smaller amounts of sulphuric acid e.g. 1-5 per cent. and in processes using mild catalysts such as zinc chloride, hydrochloric acid, ferric chloride, or stannic chloride. It may be used in processes ...

An Improved Process for Producing Cellulose Formate.

... 17,036. Kapff, S. von, and Nitritfabrik Akt.-Ges. July 21. Formates.-Cellulose formate is produced by treating cellulose in various forms with either concentrated sulphuric acid or a mixture of zinc chloride and formic acid, reprecipitating the cellulose, and, after washing &c., dissolving it in concentrated formic acid; mixtures of, for example, mono-, di-, and tri-formates result. In a modification the formate may be produced by direct treatment with a mixture of zinc chloride and concentrated formic acid.

Improvements in the Treatment of Acetyl Cellulose.

... 2178. Chemische Fabrik auf Actien (vorm. E. Schering), and Loose, A. Jan. 27. [Addition to 27,227/12.] Acetates.-The process described in the parent Specification for saponifying acetyl cellulose by heating with an aromatic amine is modified by the addition of a salt which is soluble in an aromatic amine, or which is decomposed by an aromatic amine with the formation of salt thereof; or by the addition of a compound, other than a free acid, which reacts with an aromatic amine to form an amine salt or an amide. Suitable salts are the salts of ammonia, hydrazine, alkylamines, pyridine, quinoline, piperidine, and of ethylenediamine, and also magnesium, zinc, or zinc-ammonium chlorides, and other heavy metal salts. Suitable compounds that will form amine salts or amides are sulphuryl chloride, phosphorus oxychloride, benzyl chloride, and benzene sulphochloride. The process of this Specification and of the parent Specification may also be carried out under pressure, with or without diluents.

Treatment for fabrics

Improvements in or relating to the production of cellulose esters

... 539,156. Cellulose esters. BRITISH CELANESE, Ltd. Feb. 28, 1940, No. 3704. Convention date, Feb. 28, 1939. [Class 2 (ii)] To the primary solution containing an organic ester of cellulose, the excess anhydride employed in the esterification, and an acid catalyst comprising sulphuric acid or a derivative thereof, there is added an amount of water just sufficient to convert the anhydride to acid, a further amount of water corresponding to 6-12 per cent. of the weight of cellulose ester in the primary solution and a halide of a polyvalent metal in amount at least equivalent to the acid catalyst. The cellulose ester is' allowed to ripen at a low temperature and is then precipitated from the solution. The precipitated product is obtained in a fibrous condition. The process enables cellulose esters of high acyl content, e.g. cellulose acetates of acetyl value above 55 per cent, and capable of being dissolved completely in acetone, to be obtained. The temperature of ripening may be 18‹-30‹C. The ...

Ultra-violet absorbing filters

An ultra-violet filter layer consists of a lighttransmitting film-forming material which may be any of those specified in Specification 665,371, but particularly a polyvinyl butyral composition containing a compound having one of the general formul wherein R1 is hydrogen, or an alkyl or aryl group, R2 is hydrogen or an alkyl, carboxylalkyl, alkylsulphonyl, acyl, aralkyl or aromatic group, R3 is an alkyl or aryl group, g is hydroxyl or arylamino and Z completes a quinoline ring. The ultra-violet absorbers may be added to the monomers before they are polymerized. R1 or R2 may be methyl, ethyl, propyl, butyl, amyl, octyl, dodecyl, lauryl, octadecyl, phenyl or naphthyl, or R2 may be sulphophenyl, phenylsulphophenyl, methylphenylsulphophenyl, ethylphenylsulphophenyl, p - toluylsulphonyl, benzyl, methylnaphthyl, acetyl, propionyl, butyryl, stearoyl, carbamyl, benzoyl, carboxy-methyl, carboxyethyl, methylsulphonyl or ethyl-sulphony, R3 may be phenyl or naphthyl or any of ...

Improvements in and relating to sound recording and playback apparatus using magnetic record tapes

... 876,276. Magnetic recording &c. heads; supporting. BIRMINGHAM SOUND REPRODUCERS Ltd. June 21, 1960 [July 13, 1959], No. 24040/59. Class 40 (2). A magnetic tape recorder head 5 is mounted on a block 13 on which a knife-edge 14 allows rocking about the deck or a member 4 attached thereto to provide azimuthal adjustment within the limits of the screws 18. Location in the plane of the member 4 is provided by taper pins 15 on the axis of the knife edge engaging holes in the member 4. In another embodiment, cylindrical pins may engage taper holes and the positions of the pins and holes may be transposed.

Cellulose esters

In the manufacture of cellulose esters of lower aliphatic acids, cellulose is treated with an esterifying medium comprising the appropriate aliphatic acid anhydride, methylene chloride, sulphuric acid and a minor proportion (based on the esterification mixture as a whole) of the lower aliphatic acid corresponding to the anhydride. Lower aliphatic acids are defined as those containing up to 4 carbon atoms per molecule. Cellulose from any suitable source, e.g. wood pulp or cotton linters, may be treated and is preferably given a pretreatment, e.g. with 20-100% by weight of one or more lower aliphatic acids. After pretreatment the cellulose may be treated with a mixture comprising 750-5000% of methylene chloride, 3-15% of sulphuric acid and a proportion of acid anhydride in molar ratio between 4.3 and 16.2 with respect to the cellulose (reckoned as one anhydroglucose unit), together with the appropriate lower aliphatic acid, preferably in a proportion of 10-50%, based on the methylene chloride ...

Methods for biodegradable derivatization of cellulosic surfaces

Process and device for dissolution continue chemical compounds.

Methods for biodegradable derivatization of cellulosic surfaces

Methods for biodegradable derivatization of cellulosic surfaces

POLYMERS AND YOUR SYNTHESIS

PROCEDURE FOR THE PRODUCTION OF CELLULOSECARBAMATEN

PRODUCTION OF POLYSACCHARIDBETAINATVERBINDUNGEN, MANUFACTURED CONNECTIONS, THEIR USE AND THESE CONTAINING COMPOSITIONS

PROCEDURE FOR THE PRODUCTION OF XYLOOLIGOSACCHARIDEN

CELLULOSE MATERIAL FOR ABSORBING SANITARY PRODUCTS AND PROCEDURE FOR THE PRODUCTION

PROCEDURE FOR THE PRODUCTION OF ACETYLATED WOOD

PROCEDURE FOR THE ACYLATION OF AN IN PARTICULAR CELLULOSE AND/OR HEMICELLULOSE AND/OR LIGNIN OF EXHIBITING MATERIAL AND THUS AVAILABLE MATERIAL

VERFAHREN ZUR HERSTELLUNG VON CELLULOSECARBAMATEN

VERFAHREN ZUR FAELLUNG VON ZELLULOSECARBAMAT AUS EINER ALKALISCHEN LOESUNG

CELLULOSEACYLAT AND SOLUTION OF IT

CELLULOSE MATERIAL FOR ABSORBING SANITARY PRODUCTS AND PROCEDURE FOR THE PRODUCTION

PROCEDURE FOR THE PRODUCTION OF WASSERUNBESTANDIGEN MATERIALS OF FIBROUS STRUCTURE

PROCEDURE FOR THE FILTRATION OF CELLULOSEACETAT AND PLANT FOR THE EXECUTION OF THE PROCEDURE

PROCEDURE FOR THE PRODUCTION OF CELLULOSEACETAT

SACCHARIDE-CONTAINING FUNCTIONAL ONES ORGANOPOLYSILOXANE AND PROCEDURES FOR THEIR PRODUCTION

POLYMERS AND YOUR USE

УСТРОЙСТВО ДЛЯ ЭКСТРАКЦИИ ПЕКТИНОВЫХ ВЕЩЕСТВ

1. Устройство для экстракции пектиновых веществ, содержащее привод, экстракционную камеру и рабочий орган, отличающееся тем, что привод выполнен в виде электромагнитного вибровозбудителя, состоящего из двух последовательно установленных электромагнитов, причем катушки электромагнитов закреплены в корпусе вибровозбудителя, а подвижные якори жестко связаны с рабочим органом, состоящим из штока с укрепленными на нем перфорированными дисками с отверстиями конической формы. 2. Устройство по п.1, отличающееся тем, что число витков катушки верхнего электромагнита составляет 0,75 числа витков катушки нижнего электромагнита. (19) RU (11) 17 532 (13) U1 (51) МПК C08B 37/06 (2000.01) РОССИЙСКОЕ АГЕНТСТВО ПО ПАТЕНТАМ И ТОВАРНЫМ ЗНАКАМ (12) ОПИСАНИЕ ПОЛЕЗНОЙ МОДЕЛИ К СВИДЕТЕЛЬСТВУ (21), (22) Заявка: 2000125764/20 , 11.10.2000 (24) Дата начала отсчета срока действия патента: 11.10.2000 (46) Опубликовано: 10.04.2001 (72) Автор(ы): Яцун С.Ф. (RU) , Коновалов М.Б. (RU) , Мищенко В.Я. (RU) , Сафаров Джамил Илдирович (AZ) , Селютина И.И. (RU) 1 7 5 3 2 R U (57) Формула полезной модели 1. Устройство для экстракции пектиновых веществ, содержащее привод, экстракционную камеру и рабочий орган, отличающееся тем, что привод выполнен в виде электромагнитного вибровозбудителя, состоящего из двух последовательно установленных электромагнитов, причем катушки электромагнитов закреплены в корпусе вибровозбудителя, а подвижные якори жестко связаны с рабочим органом, состоящим из штока с укрепленными на нем перфорированными дисками с отверстиями конической формы. 2. Устройство по п.1, отличающееся тем, что число витков катушки верхнего электромагнита составляет 0,75 числа витков катушки нижнего электромагнита. Ñòðàíèöà: 1 U 1 U 1 (54) УСТРОЙСТВО ДЛЯ ЭКСТРАКЦИИ ПЕКТИНОВЫХ ВЕЩЕСТВ 1 7 5 3 2 (73) Патентообладатель(и): Курский государственный технический университет (RU) R U Адрес для переписки: 305040, г.Курск, ул. 50 лет Октября 94, КГТУ, ОИС (71) Заявитель(и): Курский государственный технический ...

Process for Producing Cassava Flour

A process for the production of cassava flour having low concentration of cyanogenic compounds is described. The process is suitable for removing the cyanogenic compounds from bitter-type cassava roots using a minimum of washing steps. The resultant cassava flour has a high fiber content while having less than about 10 mg HCN equivalents/kg.

Устройство для экстракции пектиновых веществ

Устройство для экстракции пектиновых веществ, содержащее электромагнитный вибропривод, состоящий из электромагнитов, катушки которых закреплены в корпусе вибровозбудителя, экстракционную камеру и рабочий орган, состоящий из штока с укрепленными на нем перфорированными дисками с отверстиями конической формы, отличающееся тем, что привод состоит из оппозитно установленных электромагнитов, якори электромагнитов совершают угловое перемещение и упруго связаны с рабочим органом. (19) RU (11) 35 334 (13) U1 (51) МПК C08B 37/06 (2000.01) РОССИЙСКОЕ АГЕНТСТВО ПО ПАТЕНТАМ И ТОВАРНЫМ ЗНАКАМ (12) ОПИСАНИЕ ПОЛЕЗНОЙ МОДЕЛИ К ПАТЕНТУ (21), (22) Заявка: 2003127269/20 , 08.09.2003 (24) Дата начала отсчета срока действия патента: 08.09.2003 (46) Опубликовано: 10.01.2004 (72) Автор(ы): Яцун С.Ф., Мищенко В.Я., Коновалов М.Б., Сухочев А.В. U 1 3 5 3 3 4 R U Ñòðàíèöà: 1 U 1 (57) Формула полезной модели Устройство для экстракции пектиновых веществ, содержащее электромагнитный вибропривод, состоящий из электромагнитов, катушки которых закреплены в корпусе вибровозбудителя, экстракционную камеру и рабочий орган, состоящий из штока с укрепленными на нем перфорированными дисками с отверстиями конической формы, отличающееся тем, что привод состоит из оппозитно установленных электромагнитов, якори электромагнитов совершают угловое перемещение и упруго связаны с рабочим органом. 3 5 3 3 4 (54) Устройство для экстракции пектиновых веществ R U (73) Патентообладатель(и): Государственное образовательное учреждение "Курский государственный технический университет" Адрес для переписки: 305040, г.Курск, ул. 50 лет Октября, 94, КГТУ, ОИС U 1 U 1 3 5 3 3 4 3 5 3 3 4 R U R U Ñòðàíèöà: 2 RU 35 334 U1 RU 35 334 U1 RU 35 334 U1

МЕХАТРОННОЕ УСТРОЙСТВО ДЛЯ ВИБРОЭКСТРАЦИИ ПЕКТИНОВЫХ ВЕЩЕСТВ

1. Мехатронное устройство для виброэкстракции пектиновых веществ, содержащее электромагнитный вибропривод, состоящий из электромагнитов, катушки которых закреплены в корпусе вибровозбудителя, экстракционную камеру и рабочий орган, состоящий из штока с укрепленными на нем перфорированными дисками с отверстиями конической формы, привод состоит из оппозитно установленных электромагнитов, якори электромагнитов совершают угловое перемещение и упруго связаны с рабочим органом, отличающееся тем, что устройство снабжено системой управления, электрически связанной с электромагнитным виброприводом и датчиком, установленным на рабочем органе. 2. Устройство по п.1, отличающееся тем, что система управления состоит из последовательно соединенных усилителя, аналогово-цифрового преобразователя (АЦП), блока интегрирования, вычитателя, корректора ошибок (КО), сумматора, цифро-аналогового преобразователя (ЦАП), усилителя и управляемого возбудителя (УВ). РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) 43 869 (13) U1 (51) МПК C08B 37/06 (2000.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ, ПАТЕНТАМ И ТОВАРНЫМ ЗНАКАМ (12) ОПИСАНИЕ ПОЛЕЗНОЙ МОДЕЛИ К ПАТЕНТУ (21), (22) Заявка: 2004128152/22 , 21.09.2004 (24) Дата начала отсчета срока действия патента: 21.09.2004 (45) Опубликовано: 10.02.2005 4 3 8 6 9 R U Формула полезной модели 1. Мехатронное устройство для виброэкстракции пектиновых веществ, содержащее электромагнитный вибропривод, состоящий из электромагнитов, катушки которых закреплены в корпусе вибровозбудителя, экстракционную камеру и рабочий орган, состоящий из штока с укрепленными на нем перфорированными дисками с отверстиями конической формы, привод состоит из оппозитно установленных электромагнитов, якори электромагнитов совершают угловое перемещение и упруго связаны с рабочим органом, отличающееся тем, что устройство снабжено системой управления, электрически связанной с электромагнитным виброприводом и датчиком, установленным на рабочем органе. 2. Устройство по п.1, отличающееся ...

ЛИНИЯ ПРОИЗВОДСТВА ПЕКТИНА ИЗ САХАРНОЙ СВЕКЛЫ

Линия производства пектина из сахарной свеклы, содержащая последовательно соединенные сырьевой питатель, экстрактор пектина, коагулятор пектина, фильтр, сушилку, охладитель, упаковочный аппарат, отличающаяся тем, что она снабжена установленным последовательно между средством подачи сырья и экстрактором диффузионным аппаратом для предварительного извлечения сахарозы, экстрактором, работающим с помощью гидропневматических воздействий, установленным между диффузионным аппаратом и коагулятором, и коагулятором, установленным между экстрактором и фильтром, осуществляющим электрокоагуляцию пектина, без применения химических реактивов. РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) 70 248 (13) U1 (51) МПК C08B 37/06 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ, ПАТЕНТАМ И ТОВАРНЫМ ЗНАКАМ (12) ОПИСАНИЕ ПОЛЕЗНОЙ МОДЕЛИ К ПАТЕНТУ (21), (22) Заявка: 2007121493/22 , 30.05.2007 (24) Дата начала отсчета срока действия патента: 30.05.2007 (45) Опубликовано: 20.01.2008 (73) Патентообладатель(и): Общество с ограниченной ответственностью "Роста" (ООО "Роста") (RU) R U Адрес для переписки: 420043, г.Казань, а/я 227, Ф.Ф. Аухадееву (72) Автор(ы): Аухадеев Феликс Фердинандович (RU) 7 0 2 4 8 R U Ñòðàíèöà: 1 U 1 Формула полезной модели Линия производства пектина из сахарной свеклы, содержащая последовательно соединенные сырьевой питатель, экстрактор пектина, коагулятор пектина, фильтр, сушилку, охладитель, упаковочный аппарат, отличающаяся тем, что она снабжена установленным последовательно между средством подачи сырья и экстрактором диффузионным аппаратом для предварительного извлечения сахарозы, экстрактором, работающим с помощью гидропневматических воздействий, установленным между диффузионным аппаратом и коагулятором, и коагулятором, установленным между экстрактором и фильтром, осуществляющим электрокоагуляцию пектина, без применения химических реактивов. 7 0 2 4 8 U 1 (54) ЛИНИЯ ПРОИЗВОДСТВА ПЕКТИНА ИЗ САХАРНОЙ СВЕКЛЫ U 1 U 1 7 0 2 4 8 7 0 2 4 8 R U R U Ñòðàíèöà: 2 RU 5 10 15 20 ...

ЛИНИЯ ПРОИЗВОДСТВА ПЕКТИНА ИЗ САХАРНОЙ СВЕКЛЫ И СВЕКЛОВИЧНОГО ЖОМА

Линия производства пектина из сахарной свеклы и свекловичного жома, содержащая последовательно соединенные сырьевой питатель, измельчитель свеклы, диффузионный аппарат, экстрактор пектина, сушилку, охладитель, упаковочный аппарат, а также средство подачи воды, соединенное с диффузионным аппаратом, средство подачи гидролизующего агента, соединенное с экстрактором пектина, отличающаяся тем, что она снабжена аппаратом для осветления и промывки жома установленным после диффузионного аппарата, установленными последовательно после экстрактора пектина центрифугой для удаления частичек жома, электродиализатором, микрофильтрационной установкой, ультрафильтрационным модулем, осадителем, центрифугой для отделения коагулята, вакуум-выпарным аппаратом, ректификационной колонной, а также средством подачи осветлителя, соединенным с аппаратом для осветления и промывки жома, аппаратом регенерации осветлителя, соединенным со средством подачи осветлителя, средством подачи спирта, соединенным с осадителем. РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 80 454 U1 (51) МПК C08B 37/06 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ, ПАТЕНТАМ И ТОВАРНЫМ ЗНАКАМ (12) ОПИСАНИЕ ПОЛЕЗНОЙ МОДЕЛИ К ПАТЕНТУ (21), (22) Заявка: 2008139581/22, 06.10.2008 (24) Дата начала отсчета срока действия патента: 06.10.2008 (45) Опубликовано: 10.02.2009 (73) Патентообладатель(и): Общество с ограниченной ответственностью "Роста" (ООО "Роста") (RU) U 1 8 0 4 5 4 R U Ñòðàíèöà: 1 ru CL U 1 Формула полезной модели Линия производства пектина из сахарной свеклы и свекловичного жома, содержащая последовательно соединенные сырьевой питатель, измельчитель свеклы, диффузионный аппарат, экстрактор пектина, сушилку, охладитель, упаковочный аппарат, а также средство подачи воды, соединенное с диффузионным аппаратом, средство подачи гидролизующего агента, соединенное с экстрактором пектина, отличающаяся тем, что она снабжена аппаратом для осветления и промывки жома установленным после диффузионного аппарата, ...

УСТРОЙСТВО ДЛЯ ЭКСТРАКЦИИ ПЕКТИНОВЫХ ВЕЩЕСТВ

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Машина для разделения крахмалосодержащих суспензий

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Линия получения лекарственного средства Na-, Fe-, Ca-полигалактуронат

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Установка для электрохимической переработки отходов от разделки ракообразных

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Устройство для изготовления модифицированных крахмалов

Полезная модель относится к пищевой промышленности и может быть использована при изготовлении модифицированных крахмалов, например, из дробленого зерна или измельченного картофеля, а также других крахмалсодержащих продуктов. Технической задачей полезной модели является расширение функциональных возможностей устройства, включающих дополнительную обработку переработанного сырья химическими реактивами при производстве модифицированного крахмала. Технически задача решена за счет того, что устройство для изготовления модифицированных крахмалов, содержащее корпус с загрузочным бункером, внутри которого жестко зафиксирован очистительный нож, полый перфорированный ротор и прессующий вал, связанные с разгрузочным шнеком, отличающееся тем, что внутри корпуса неподвижно зафиксирована пропиточная ванна, заполненная химическим реагентом, пополнение которого осуществляется за счет использования поплавкового регулятора, к стенке которой жестко зафиксированы верхний опорный валик, прижимной валик и опорный валик, их наружную поверхность и прессующий вал огибает сетка из упругого пористого материала, концы которой соединены между собой, при этом сетка, проходя через ванну между верхним опорным валиком и прижимным валиком, упруго сжимается, а после этого восстанавливает свою форму, впитывая химический реактив. И 1 202984 ко РОССИЙСКАЯ ФЕДЕРАЦИЯ ВУ” 202 984” 44 ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ИЗВЕЩЕНИЯ К ПАТЕНТУ НА ПОЛЕЗНУЮ МОДЕЛЬ ММ9К Досрочное прекращение действия патента из-за неуплаты в установленный срок пошлины за поддержание патента в силе Дата прекращения действия патента: 13.03.2021 Дата внесения записи в Государственный реестр: 25.05.2022 Дата публикации и номер бюллетеня: 25.05.2022 Бюл. №15 Стр.: 1 па уз6с0с ЕП

Устройство для тонкого измельчения крахмалосодержащего сырья

Полезная модель относится к крахмалопаточному производству и предназначена для истирания преимущественно картофеля для получения картофельной кашки и может быть использована в линиях по приготовлению модифицированных крахмалов с ведением химических реагентов. Устройство для тонкого измельчения крахмалсодержащего сырья состоит из цилиндрического корпуса с загрузочным бункером, установленного внутри него горизонтально на валу барабана, на наружной поверхности которого укреплено терочное средство в виде гибкой стальной ленты, размещенной на наружной поверхности барабана и снабженной расположенными по всему периметру вдоль барабана полосами из абразивных частичек, расположенной в нижней части корпуса решетки для измельченного продукта и прижима для регулирования степени измельчения, при этом прижим выполнен полым и перфорированным со стороны дугообразной обечайки, обращенной в сторону терочного средства, а со стороны стенки терочного средства прижим снабжен каналом, обеспечивающим возможность подачи химического реагента. Технический результат предлагаемой полезной модели заключается в повышении производительности и его универсальности. 2 ил. РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 204 881 U1 (51) МПК C08B 30/02 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ОПИСАНИЕ ПОЛЕЗНОЙ МОДЕЛИ К ПАТЕНТУ (52) СПК C08B 30/02 (2021.05) (21)(22) Заявка: 2021107960, 25.03.2021 (24) Дата начала отсчета срока действия патента: Дата регистрации: 16.06.2021 (45) Опубликовано: 16.06.2021 Бюл. № 17 2 0 4 8 8 1 R U (56) Список документов, цитированных в отчете о поиске: SU 1643555 A1, 23.04.1991. RU 2039067 C1, 09.07.1995. RU 2039753 C1, 20.07.1995. CN 209138643 U, 23.07.2019. CN 110003347 A, 12.07.2019. (54) Устройство для тонкого измельчения крахмалосодержащего сырья (57) Реферат: Полезная модель относится к и снабженной расположенными по всему крахмалопаточному производству и периметру вдоль барабана полосами из предназначена для истирания преимущественно абразивных ...

Устройство для изготовления модифицированных крахмалов

Полезная модель относится к пищевой промышленности и может быть использована при изготовлении модифицированных крахмалов, например из дробленого зерна или измельченного картофеля, а также других крахмалсодержащих продуктов. Технический результат, заключающийся в увеличении разнообразия видов получаемых модифицированных крахмалов достигается за счет того, что устройство для получения модифицированных крахмалов, содержащее вальцовую сушилку, установленный над ней бункер-питатель клейстеризованного крахмала и клейстеризатор, который состоит из двух параллельно расположенных с зазором валков, отличающееся тем, что каждый из валков выполнен в виде двух коаксиальных цилиндров, причем наружные цилиндры выполнены в виде перфорированных обечаек и установлены с возможностью встречного вращения вокруг общих с закрепленными неподвижно внутренними цилиндрами осей, внутренние цилиндры снабжены осевыми полостями, которые соединены магистралями с емкостью с подогретым химическим реагентом, и каждый внутренний цилиндр оснащен парой форсунок, ориентированных в сторону зазора и размещенных симметрично относительно прямой, соединяющей оси вращения валков. РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 205 832 U1 (51) МПК C08B 30/02 (2006.01) B02C 4/00 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ОПИСАНИЕ ПОЛЕЗНОЙ МОДЕЛИ К ПАТЕНТУ (52) СПК C08B 30/02 (2021.05); B02C 4/00 (2021.05) (21)(22) Заявка: 2021107917, 25.03.2021 (24) Дата начала отсчета срока действия патента: Дата регистрации: 11.08.2021 (45) Опубликовано: 11.08.2021 Бюл. № 23 2 0 5 8 3 2 R U (56) Список документов, цитированных в отчете о поиске: SU 771191 A1, 15.10.1980. UZ 2856 C, 31.10.2005. BY 18335 C1, 30.06.2014. RU 202984 U1, 17.03.2021. CN 203513542 U, 02.04.2014. (54) Устройство для изготовления модифицированных крахмалов (57) Реферат: Полезная модель относится к пищевой валков, отличающееся тем, что каждый из валков промышленности и может быть использована выполнен в виде двух коаксиальных цилиндров, ...

УСТРОЙСТВО ДЛЯ ИЗМЕЛЬЧЕНИЯ КРАХМАЛСОДЕРЖАЩЕГО СЫРЬЯ

Полезная модель может быть использована в пищевой промышленности для предварительной подготовки крахмалсодержащего сырья при получении из него модифицированных крахмалов. Существо технического решения состоит в устранении имеющихся недостатков устройств, известных в этой области, для чего устройство для измельчения крахмалсодержащего сырья, содержащее станину с закрепленным на ней загрузочным бункером, цилиндрический корпус с выпускным отверстием, ножевые стенки и центробежный ротор, выполненный секционированным с секциями, снабженными ножевыми стенками и закрепленными на кромках, выполненных в обечайке ротора прямоугольных окон и обращенных острием к измельчаемому продукту, с осью вращения, ориентированной горизонтально, причем каждая из секций ротора со стороны, обращенной к его продольной оси вращения, снабжена щелевым соплом, по оси вращения установлен цилиндр, вдоль образующей обечайки которого выполнена прорезь посередине плоскости ротора, обращенная в сторону загрузочного бункера, а со стороны разгрузки продукта из ротора противоположно загрузочному бункеру установлен фрикционный привод вращения. 1 ил. 206120 Ц ко РОССИЙСКАЯ ФЕДЕРАЦИЯ ВУ” 206 120” 94 ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ИЗВЕЩЕНИЯ К ПАТЕНТУ НА ПОЛЕЗНУЮ МОДЕЛЬ ММ9К Досрочное прекращение действия патента из-за неуплаты в установленный срок пошлины за поддержание патента в силе Дата прекращения действия патента: 17.04.2021 Дата внесения записи в Государственный реестр: 22.06.2022 Дата публикации и номер бюллетеня: 22.06.2022 Бюл. №18 Стр.: 1 0190С па ЕП

АППАРАТ ДЛЯ ПРОИЗВОДСТВА МОДИФИЦИРОВАННОГО КРАХМАЛА

Полезная модель относится к пищевой промышленности и может быть использована для изготовления модифицированного крахмала, из дробленого зерна или измельченного картофеля. Технической задачей полезной модели является сократить продолжительность производства готовой продукции за счет расширения функциональных возможностей устройства и повышения показателей качества готовой продукции. Технический результат достигается за счет того, что аппарат для производства модифицированного крахмала, содержащий корпус с загрузочным бункером, внутри которого жестко зафиксирован очистительный нож, полый перфорированный ротор и прессующий вал, связанные с разгрузочными шнеками, зафиксированными внутри полого перфорированного ротора и прессующего вала, причем на внешней стороне корпуса зафиксирован двигатель через ремень, связанный с разгрузочными шнеками, полый перфорированный ротор и прессующий вал соприкасаясь образуют рабочую зону, в которой происходит измельчение и продавливание крахмала в обе стороны через перфорацию и в которую подается химический реагент на ленте из упругого пористого материала, вращение которой обеспечивают верхний опорный валик, прижимной валик и опорный валик, зафиксированные на стенке пропиточной ванны с химическим реагентом, которая неподвижно зафиксирована над рабочей зоной, причем лента между верхним опорным валиком и прижимным валиком упруго сжимается, а затем ее форма восстанавливается и впитывает химический реактив из пропиточной ванны. 2 ил. РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 206 667 U1 (51) МПК C08B 30/00 (2006.01) B02C 4/00 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ОПИСАНИЕ ПОЛЕЗНОЙ МОДЕЛИ К ПАТЕНТУ (52) СПК C08B 30/00 (2021.05); B02C 4/00 (2021.05) (21)(22) Заявка: 2020141698, 16.12.2020 (24) Дата начала отсчета срока действия патента: Дата регистрации: 21.09.2021 (45) Опубликовано: 21.09.2021 Бюл. № 27 Адрес для переписки: 412913, Саратовская обл., Вольский р-н, г. Вольск, ул. Комбайнеров, 73В, кв. 2, Филинов Сергей ...

Машина для производства модифицированного крахмала

Полезная модель относится к пищевой промышленности и может быть использована при изготовлении модифицированных крахмалов, например, из дробленого зерна или измельченного картофеля, а также других крахмалосодержащих продуктов. Технической задачей является придание возможности обработки перерабатываемого сырья химическими реактивами для изготовления модифицированного крахмала в едином устройстве и технологической цепи. Техническая задача решена за счет того, что машина для производства модифицированного крахмала, содержащая корпус с загрузочным бункером, внутри которого жестко зафиксирован очистительный нож, полый перфорированный ротор и прессующий вал, связанные с разгрузочным шнеком, отличающаяся тем, что на внешней стороне прессующего вала зафиксирована лента, изготовленная из ленты упругого пористого материала, облегающая верхний опорный валик, прижимной валик и опорный валик, зафиксированные с возможностью вращаться в стенке ванны, которая заполняется химическим реагентом за счет использования поплавкового регулятора, установленного внутри, при этом лента, проходя через ванну между верхним опорным валиком и прижимным валком, упруго сжимается, а после этого восстанавливает свою форму, впитывая химический реактив, а также готовый продукт шнеком подается в лоток, жестко зафиксированный на внешней стороне корпуса, а его работа обеспечивается двигателем, связанным через ремень. РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 206 922 U1 (51) МПК C08B 30/00 (2006.01) B02C 4/00 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ОПИСАНИЕ ПОЛЕЗНОЙ МОДЕЛИ К ПАТЕНТУ (52) СПК C08B 30/00 (2021.05); B02C 4/00 (2021.05) (21)(22) Заявка: 2020133216, 08.10.2020 (24) Дата начала отсчета срока действия патента: Дата регистрации: 01.10.2021 (45) Опубликовано: 01.10.2021 Бюл. № 28 Адрес для переписки: 199034, Санкт-Петербург, наб. Макарова, 8, "Военная академия материально-технического обеспечения", ООНР 2 0 6 9 2 2 U 1 (56) Список документов, цитированных в отчете о поиске: ...

Biotechnological Production of Chondroitin

Chondroitin is produced by culturing a recombinant microorganism which is obtained by inactivation of a gene encoding an enzyme responsible for addition of fructose residues to the linear chondroitin polysaccharide in a microorganism producing a fructosylated derivative of chondroitin.

Modified heparinase iii and methods of sequencing therewith

The invention relates to heparinase III and mutants thereof. Modified forms of heparinase III having reduced enzymatic activity which are useful for a variety of purposes, including sequencing of heparin-like glycosaminoglycans (HLGAGs), removing active heparan sulfate from a solution, inhibition of angiogenesis, etc. have been discovered according to the invention. The invention in other aspects relates to methods of treating cancer and inhibiting tumor cell growth and/or metastasis using heparinase III, or products produced by enzymatic cleavage by heparinase III of HLGAGs.

Conjugates of hydroxyalkyl starch and a protein, prepared by native chemical ligation

Conjugates of an active substance and hydroxyalkyl starch (HAS) are provided herein. The active substance and the HAS are linked by a chemical moiety having a structure according to formula (I) wherein Y is O or S, and X is SH or (F). The conjugate has a structure according to formula (IV) wherein HAS′ is a residue of HAS or a derivative thereof linked to the thioester group, and AS′ is a residue of the active substance or derivative thereof linked to the alpha-X beta-amino group; or a structure according to formula (V) wherein HAS′ is a residue of HAS or derivative thereof linked to the alpha-X beta-amino group, and AS′ is a residue of the active substance or derivative thereof linked to the thioester group, and wherein the group —(C═Y) is derived from the thioester group —(C═Y)—S—R′ and the group HN—CH—CH 2 —X is derived from the alpha-X beta amino group.

Method for purifying glucose polymers for peritoneal dialysis solutions

The invention relates to a method of purifying glucose polymers for the production of peritoneal dialysis solutions, characterized in that it includes at least one step of processing activated carbon and/or granular black, at least one sterilizing filtration step, at least one heat treatment step, and at least one ultrafiltration step.

Polysaccharide pseudo-sponge

A photocrosslinked polysaccharide pseudo-sponge exhibiting a low swelling property and a high degradation ability in vivo while retaining a suitable strength. The polysaccharide pseudo-sponge is produced by a crosslinking reaction of a photoreactive polysaccharide obtained by introducing a photoreactive group into a polysaccharide, and exhibits a low swelling property and a blue dextran-low dyeaffinity.

Cyclodextrin-based polymers for therapeutics delivery

The present invention relates to novel compositions of therapeutic cyclodextrin containing polymeric compounds designed as a carrier for small molecule therapeutics delivery and pharmaceutical compositions thereof. These cyclodextrin-containing polymers improve drug stability and solubility, and reduce toxicity of the small molecule therapeutic when used in vivo. Furthermore, by selecting from a variety of linker groups and targeting ligands the polymers present methods for controlled delivery of the therapeutic agents. The invention also relates to methods of treating subjects with the therapeutic compositions described herein. The invention further relates to methods for conducting pharmaceutical business comprising manufacturing, licensing, or distributing kits containing or relating to the polymeric compounds described herein.

Treatment of fibres to endure processing

The invention relates to a method of treating chemical pulp fibres by a polymerizing hydroxy acid, the fibres thus obtained and the products refined from them. In the method, the hydroxy acid reacts with the reactive groups of the fibres in the presence of a catalyst, forming ester bonds. The following units of the same hydroxy acid are oligomerized and/or polymerized to these grafted acid residues. The fibres thus treated and the products refined thereof endure better processing stages that include drawing and stretching than untreated fibres.

Polymers and Hydrogels

Methods and compositions related polymers and hydrogels. In some cases to biodegradable hydrogels for use in medical applications are disclosed. The polymers and hydrogels may be produced from cross-linked dextran and poly(epoxides). The poly(epoxides) may be poloxamers.

Immuno-compatible hydrogel system

An immuno-compatible hydrogel system is provided that is resistant to protein binding. The hydrogel system is prepared by contacting a hydrogel solution with a cross-linking agent to form a gel, exposing the gel to an aqueous solution comprising a first polyelectrolyte to form a polyelectrolyte-coated hydrogel, exposing the polyelectrolyte-coated hydrogel to a second polyelectrolyte to form a crosslinked matrix and exposing the matrix to conditions which eliminates, or at least reduces, protein binding sites on the matrix.

Bismuth-containing compounds, coordination polymers, methods for modulating pharmacokinetic properties of biologically active agents, and methods for treating patients

Bismuth-containing compounds include bismuth and a biologically active agent coordinated to the bismuth. The biologically active agent includes at least one heteroatom configured for coordination with the bismuth. Coordination polymers include a polymer matrix that contains a bismuth-containing compound. Methods for modulating a pharmacokinetic property of a biologically active agent include coordinating the biologically active agent to bismuth to form a bismuth-containing compound, and administering the bismuth-containing compound orally to a patient. Methods for treating Parkinson's disease, methods for treating hypothyroidism, methods for treating ulcerative colitis, and methods for treating cancer each include administering a bismuth-containing compound to a patient.

Porous composite biomaterials and production method of the same

The invention discloses a porous composite biomaterial comprising of poly(γ-glutamic acid)-g-chondroitin sulfate (γ-PGA-g-CS) copolymer and poly(ε-caprolactone). The composite biomaterial provides a three-dimensional microenviroment for using as a scaffold for tissue engineering and for supporting the attachment and proliferation of cells. The invention also discloses a method of producing a porous composite biomaterial.

Modified hyaluronic acid polymer compositions and related methods

The present application provides compositions comprising hyaluronic acid having low levels of functional group modification, mixtures formed by controlled reaction of such lightly modified hyaluronic acid with suitable difunctional or multi-functional crosslinkers, and hydrogel precursor compositions and the resulting hydrogels. The compositions are lightly cross-linked and possess low pro-inflammatory properties when injected in vivo, and can be used as, for example, medical devices, biomedical adhesives and sealants, and for localized delivery of bioactive agents, among other uses.

Aptamer bioconjugate drug delivery device

A delivery device for an active agent comprises nanoparticles based on a biopolymer such as starch. The delivery device may also be in the form of an aptamer-biopolymer-active agent conjugate wherein the aptamer targets the device for the treatment of specific disorders. The nanoparticles may be made by applying a high shear force in the presence of a crosslinker. The particles may be predominantly in the range of 50-150 nm and form a colloidal dispersion of crosslinked hydrogel particles in water. The biopolymer may be functionalized. The aptamer may be conjugated directly to the cross-linked biopolymers. The active agent may be a drug useful for the treatment of cancer. The delivery device survives for a period of time in the body sufficient to allow for the sustained release of a drug and for the transportation and uptake of the conjugate into targeted cells. However, the biopolymer is biocompatible and resorbable.

Solvolysis of biomass using solvent from a bioreforming process

The present invention provides processes for deconstructing biomass using a solvent produced in a bioreforming reaction.

Macroporous Microcarrier Specific to Liver Cell, Preparation Method and Use Thereof

The present invention provides a macroporous microcarrier specific to hepatocytes using silk fibroin and galactosylated chitosan as main raw material, a preparation method thereof, and application for hepatocyte culture under the culture condition of microgravity rotation. The macroporous microcarrier s a sphere prepared from silk fibroin and galactosylated chitosan under the effect of crosslinker, wherein based on the total weight of the sphere, the content of silk fibroin is 50-80 wt % and the content of galactosylated chitosan is 15-40 wt %. The diameter of the microcarrier is 200-500 μm, and the aperture of the microcarrier is 40-80 μm. Compared with normal solid scaffold material, the microcarrier provided by the present invention has larger surface area/volume ratio and, a sinus gap structure extremely similar with in-vivo liver sinus structure, therefore it is more conducive to adhering of the hepatocytes on the scaffold material, contacting between cells, transporting oxygen and nutrient components and excreting metabolic products.

Viscoelastic gels as novel fillers

Biomaterials obtainable by mixing the autocrosslinked derivative of hyaluronic acid (ACP) with the derivative (HBC) of hyaluronic acid crosslinked with 1,4-butanediol diglycidyl ether (BDDE) in the weight ratio of between 10:90 and 90:10 as novel fillers.

Methods for Steam Flash Extraction of Pectin

Methods are provided for high temperature and short time extraction of pectins from pectin-containing plant materials. Generally described, the method includes mixing the pectin-containing plant material and an acidic aqueous medium to form a mixture; heating the mixture (optionally under pressure) to a target temperature by steam injection; maintaining the mixture under pressure at the target temperature for a time up to about 5 minutes; and flashing the mixture into a flash tank at a pressure from about 0.5 to about 1.2 bar to extract pectin from the pectin-containing plant material.

Production method of 11-sugar sialylglycopeptide

It is an object of the present invention to provide a method for producing an 11-sugar sialylglycopeptide easily and with good yield and a high degree of purity on an industrial scale from defatted bird egg yolks. The present invention provides a production method of an 11-sugar sialylglycopeptide. More specifically, the present invention provides a production method of an 11-sugar sialylglycopeptide comprising: an extraction step of extracting defatted bird egg yolks with water or a salt solution to obtain a liquid extract of a glycopeptide, a precipitation step of adding the liquid extract to a water-soluble organic solvent to precipitate the glycopeptide, and a desalting step of desalting the precipitate.

Cellulose Ester Optical Films

Regioselectively substituted cellulose esters having a plurality of aryl-acyl substituents and a plurality of alkyl-acyl substituents are disclosed along with methods for making the same. Such cellulose esters may be suitable for use in optical films, such as optical films having certain Nz values, −A optical films, and/or +C optical films. Optical films prepared employing such cellulose esters have a variety of commercial applications, such as, for example, as compensation films in liquid crystal displays and/or waveplates in creating circular polarized light used in 3-D technology.

Depolymerized glycosaminoglycan from thelenota ananas and preperation method thereof

Disclosed is a depolymerized glycosaminoglycan from Thelenota ananas (dTHG), weight average molecular weight of which is about 8000˜20000 Da, and monosaccharide components of which are acetylgalactosamine (GalNAc), glucuronic acid (GlcUA), fucose (Fuc) or their sulfates (expressed as —OSO 3− ), in which molar ratio of GalNAc:GlcUA:Fuc:—OSO 3− is about 1:(1±0.3):(1±0.3):(3.5±0.5). Said dTHG is a potent endogenous inhibitor of factor X, which has good anticoagulant and antithrombotic activity, and can be used for the prevention and/or treatment of thrombotic diseases. Also provided is a method for preparing said dTHG, which comprises steps of 1) extracting and obtaining fucosylated glycosaminoglycan (THG) from the body wall of Thelenota ananas ; 2) depolymerizing THG to obtain dTHG by method of peroxide depolymerization or method of peroxide depolymerization catalyzed by catalyst of the fourth period transition metal ions; 3) removing impurities with lower and/or higher molecular weight in dTHG.

Compositions and methods for preparing staphylococcus aureus serotype 5 and 8 capsular polysaccharide conjugate immunogenic compositions

The present invention relates to immunogenic conjugates comprising S. aureus serotype 5 and 8 capsular polysaccharides conjugated to carrier proteins and methods for their preparation and use. Methods for making the immunogenic conjugates of the invention involve covalent conjugation of the capsular polysaccharides with the carrier proteins using conjugation chemistry involving either 1,1-carboyl-di-1,2,4-triazole (CDT) or 3-(2-pyridyldithio)-propionyl hydrazide (PDPH).

Metal-polysaccharide conjugates: compositions, synthesis and methods for cancer therapy

The current disclosure, in one embodiment, includes a polysaccharide conjugate. This conjugate has a polysaccharide and at least one liner covalently bound to the polysaccharide. The conjugate also has at least one metal conjugated by said linker. According to another embodiment, the disclosure provides a method of synthesizing a polysaccharide conjugate by covalently bonding a linker to a polysaccharide to obtain an intermediate and by conjugating said intermediate to a metal to form a polysaccharide conjugate. This conjugate has a higher relaxivity, so it is suitable to be used as a contrast medium for hybrid camera.

Cell surface coating with hyaluronic acid oligomer derivative

A method of localising reproduction assisting hyaluronic acid to reproductive cell surfaces by covalently linking it to lipids is disclosed.

Acetylated cellulose ether and articles comprising the same

Acetylated cellulose ether and an article including the same. The acetylated cellulose ether has a degree of substitution (DS) of alkyl group of 1 to 2, a molar substitution (MS) of hydroxyalkyl group of 0 to 1, and a degree of substitution (DS) of acetyl group of 1 to 2.

Microprocessing for preparing a polycondensate

The present invention relates to a process for preparing polydextrose by using a microdevice. It further relates to the use of a microdevice for the polycondesation reactions.

Modified pectins, compositions and methods related thereto

The present invention provides compositions of modified pectin and methods for preparing and using them.

Cellulose nanofibers, method for producing same, composite resin composition and molded body

The present invention is cellulose nanofibers having an average polymerization degree of 600 to 30000, an aspect ratio of 20 to 10000, an average diameter of 1 nm to 800 nm, and an Iβ-type crystal peak in an X-ray diffraction pattern.

Allergy inhibitor

The present invention provides an allergy inhibitor using the efficacy of amorphous paramylon which is a substance obtained by changing the crystalline structure of paramylon. The present invention relates to a substance for inhibiting allergic diseases. Amorphous paramylon of the present invention is an allergy inhibitor comprising amorphous paramylon which is obtained by amorphosizing crystalline paramylon derived from Euglena, and has a relative crystallinity of 20% or lower to the crystallinity of crystalline paramylon, determined by an X-ray diffractometry. This allergy inhibitor enables efficacious inhibition of allergic diseases such as atopic dermatitis, pollinosis, and the like.

Heterogeneous thiol-ene click modifications of solid polysaccharide-based materials

This invention concerns the first environmentally benign heterogeneous modification of polysaccharide-based material in native solid state by thiol-ene “click chemistry”. The direct reaction of a thiol with an un-activated double or triple bond by thiol-ene and thiol-enyne click modification is thermally or photochemically catalyzed and is completely metal-free and allows for a highly modular approach to modifications of fibers and fiber-based materials.

Anti-allergic agent

According to the present invention, an anti-allergic agent is provided which includes a polysaccharide comprising galactose, glucose and rhamnose as constituents, or includes a microorganism belonging to a genus Bifidobacterium and extracellularly producing the polysaccharide. The anti-allergic agent of the present invention can be used in oral compositions and compositions for external application, and is suitable for use in products such as food products, pharmaceutical products, and cosmetics.

Method for synthesizing calixarene and/or cyclodextrin copolymers, terpolymers and tetrapolymers, and uses thereof

The present invention relates to a novel method for synthesizing a composition of polymers, copolymers, terpolymers and tetrapolymers, and to the use thereof, said composition being made from: cyclodextrins, in particular α-cyclodextrin, β-cyclodextrin, γ-cyclodextrin, the derivatives thereof or the corresponding mixtures thereof; and/or calix[n]arene(s) and/or calix[n]arene derivative(s) and/or a mixture of two or more different calix[n]arenes selected from calix[n]arenes (n=4-20) and/or the derivatives thereof, and to the uses thereof. A method was developed on the basis of bulk polycondensation by heating. The invention can be used in the pharmaceutical, human medicine, veterinary medicine, chemistry, separation chemistry, environmental, electronics, biology, diagnostics, phytosanitation, medicinal food, agri-food, and cosmetics fields, and in the nutraceutical field and in the field of molecular imprints (MIP).

Phase separated composite

A composite is disclosed. The composite comprises a first conjugate of a polymer and a first phenol-containing moiety, and a second conjugate of a gelatin or collagen and a second phenol-containing moiety, wherein the polymer is selected so that the first conjugate is less cell-adhesive than the second conjugate, at least one of the first and second conjugates is crosslinked to form a matrix, and the composite comprises discrete regions that are rich in one of said first and second conjugates. A method of forming such composite is also disclosed. The method comprises mixing precursors for the first and second conjugates in a solution for forming said composite, and dispersing a catalyst in the solution to catalyze crosslinking of at least one of the first and second conjugates to form the matrix. The composite may be used to grow cells.

NOVEL PROCESS

A single-phase LPS extraction composition comprising water, an alcohol and a further organic solvent, where the amount of water is between about 0.8 to 1.2% (v/v). 1. An LPS extraction composition comprising water , an alcohol and a further organic solvent.2. The composition of wherein the LPS extraction composition is single-phase.3. The composition of or wherein the amount of water in the LPS extraction composition is between about 0.1 and about 1.5% (v/v).4. The composition of any of to wherein the amount of water is about 1% (v/v).5. The composition of any of to wherein the amount of water is about 0.5% (v/v).6. The composition of any of to wherein the alcohol is selected from the list: methanol claim 1 , ethanol claim 1 , isopropanol or butanol.7. The composition of any of to wherein the percentage of alcohol in the LPS extraction composition is between about 5% and about 40% (v/v).8. The composition of wherein the percentage of alcohol is between about 10% (v/v) and about 30% (v/v).9. The composition of any preceding claim wherein the further organic solvent is selected from the group: chloroform claim 7 , alkanes claim 7 , toluene and petroleum ether.10. The composition of wherein the alkane is selected from the group: isooctane claim 9 , ethane claim 9 , heptane and hexane.11. The composition of any preceding claim wherein the percentage of the further organic solvent in the LPS extraction composition is between about 60% (v/v) and about 95% (v/v).12. The composition of wherein the percentage of the further organic solvent is between about 75% (v/v) and about 90% (v/v).13. The composition of any of to wherein the LPS extraction solution comprises chloroform claim 11 , methanol and water.14. The composition of any of to wherein the LPS extraction composition comprises an alkane claim 11 , ethanol and water.15. A composition according to any of to for use in the extraction of LPS from gram negative bacterial cells.16. Use of an LPS extraction composition ...

NOVEL CHELATOR AND USE THEREOF

The present invention relates to dimeric pentadentate chelators with exceptionally strong binding of metal ions, for detection, immobilization and purification of biomolecules. Dimeric chelators offer a cooperativity of binding of two adjacent immobilized metal ions simultaneously to a histidine-tagged biomolecule, which gives advantageous properties regarding strength of binding compared to a corresponding monomer chelator. In addition, a dimer increases the selectivity (ease of separation) against non-tagged biomolecules with low metal-ion affinity. 2. The dimeric pentadentate chelator of claim 1 , wherein Sc comprises three functional groups in its structure and has the following general formula: (Z)-Sca-Wbefore coupling to PD claim 1 , wherein Zand Ware selected from —OH claim 1 , —SH or —OCHCH═CH claim 1 , —COH claim 1 , —NHor —NH— claim 1 , —N claim 1 , CN claim 1 , OTs claim 1 , OMs claim 1 , Cl claim 1 , Br claim 1 , —CHO claim 1 , —C≡CH or epoxide groups claim 1 , such that they can be functionalized/derivatized in an orthogonal fashion claim 1 , and Sca is a straight claim 1 , branched or cyclic configuration of 2-100 atoms comprising C claim 1 , N claim 1 , O claim 1 , S and H.3. The dimeric pentadentate chelator of claim 1 , wherein Sc comprises two amine functions in its structure.4. The dimeric pentadentate chelator of claim 1 , wherein Sc comprises three amine functions in its structure and most preferably is derived from diethylentriamine.6. The dimeric pentadentate chelator claim 5 , wherein the spacer Sp1 is derived from 6-amino hexanoic acid.8. The dimeric pentadentate chelator of claim 7 , wherein Q is a solid phase comprising a natural or synthetic polymer.9. The dimeric pentadentate chelator of claim 7 , wherein the solid phase is a porous chromatographic support.10. The dimeric pentadentate chelator of claim 8 , wherein Q is made of a cross-linked carbohydrate material selected from the group consisting of agarose claim 8 , agar claim 8 , ...

SEPARATING AGENT FOR OPTICAL ISOMERS

The present invention provides a separating agent for optical isomers that contains a cellulose derivative or amylose derivative that has an excellent enantioselective recognition ability. The present invention comprises a separating agent for optical isomers that uses a polysaccharide derivative provided by replacing all or a portion of the hydrogen atoms on the hydroxyl groups present in a polysaccharide with two specific atomic groups that act on optical isomers targeted for separation in an optical resolution, wherein the sum of the average introduction ratios of specific terminal substituents in these atomic groups is greater than 3.0 per monosaccharide unit. 2. The separating agent for optical isomers according to claim 1 , wherein the X represents an amide bond.3. The separating agent for optical isomers according to claim 2 , wherein the R1 and R2 are the same. The present invention relates to a separating agent for optical isomers.The physical and chemical properties of optical isomers are entirely the same, but in some cases differences are seen in their functions to biological body. As a consequence, the production of compounds that exhibit a high optical purity is an extremely important problem in fields such as medicines and pharmaceuticals. Fractionation methods based on high-performance liquid chromatography using separating agents for optical isomers are known to be techniques that respond to this problem.Among the numerous separating agents for optical isomers, an enantioselective recognition ability for a broad range of compounds is known to be exercised in particular by separating agents in which a carbamate or ester derivative of a cellulose or amylose is supported on a silica gel.Investigations are underway to improve the chromatographic fractionation productivity of chromatographic fractionation methods, and there is desire for a separating agent for optical isomers that provides an even better separation of the compounds to be fractionated, i. ...

PROCESS FOR MANUFACTURING TAGATOSE AND GLUCOSE

An economically feasible process for manufacturing tagatose is provided. The process includes hydrolyzing lactose to galactose and glucose, separating galatose from hydrolysates, and isomerizing galactose to tagatose with metal hydroxide in an aqueous suspension. 1. (canceled)2. A process for manufacturing tagatose , comprising the step: c) reaction of an aqueous suspension of galactose under the presence of metal ions and alkaline condition to convert galactose into tagatose , wherein step c) is carried out by adding an aqueous slurry of metal hydroxide into an aqueous suspension of galactose.3. The process according to further comprises claim 2 , before the step c) claim 2 , the following steps: a) hydrolysis of lactose with mineral acid in an aqueous solution to convert lactose to galactose and glucose; b) separation of the galactose and glucose from the hydrolyzate obtained in step a).4. The process according to claim 2 , wherein said suspension in step c) has a galactose content of more than 30% by weight.5. The process according to claim 2 , wherein said step c) is performed at 0-30° C.6. The process according to claim 2 , wherein said step c) is performed with a molar ratio of metal hydroxide to galactose of 0.5:1-2:1.7. The process according to claim 3 , wherein said step a) is performed with 0.02-0.6 M mineral acid.8. The process according to claim 3 , wherein said step a) is performed under 90-120° C.9. The process according to claim 3 , wherein the content of lactose in said step a) is more than 30% by weight.10. The process according to claim 3 , wherein said step b) is performed by chromatographic separation.11. The process according to claim 10 , wherein water is used as eluent during the chromatographic separation.12. The process according to claim 3 , wherein said mineral acid is one or more selected from the group consisting of carbonic acid claim 3 , hydrochloric acid claim 3 , phosphoric acid and sulfuric acid.13. The process according to claim 2 ...

WATER SOLUBLE REACTIVE DERIVATIVES OF CARBOXY POLYSACCHARIDES AND FIBRINOGEN CONJUGATES THEREOF

The present invention provides water-soluble reactive esters of carboxy polysaccharides and derivatives thereof. The reactive carboxy polysaccharide derivatives are useful per se in aqueous solutions or specifically for the formation of water-soluble covalent fibrinogen conjugates. A preferred conjugate is a hyaluronic acid-fibrinogen conjugate and fibrin adhesive, clot or matrix derived from it. Methods of preparation and methods of use in tissue repair and regeneration are also disclosed. 1. An aqueous solution comprising a N-hydroxysuccinimide carboxy polysaccharide active ester , wherein the aqueous solution is substantially free of an activator.2. The aqueous solution according to claim 1 , wherein the carboxy polysaccharide is selected from the group consisting of a natural carboxy polysaccharide claim 1 , a synthetic carboxy polysaccharide claim 1 , a semi-synthetic polysaccharide claim 1 , and combinations thereof.3. The aqueous solution according to claim 2 , wherein the carboxy polysaccharide is a chemically modified carboxy polysaccharide with a chemical group or moiety selected from the group consisting of: a hydroxyl group claim 2 , a Michael acceptor group claim 2 , a coordinated metal group claim 2 , a nitro-group claim 2 , a halo group claim 2 , and a haloacyl group.4. The aqueous solution according to claim 2 , wherein the natural carboxy polysaccharide is a glycosaminoglycan selected from the group consisting of hyaluronic acid claim 2 , heparin claim 2 , heparan sulfate claim 2 , chondroitin sulfate claim 2 , dermatan sulfate claim 2 , keratan sulfate claim 2 , combinations claim 2 , derivatives claim 2 , and salts thereof.5. The aqueous solution according to claim 3 , wherein said glycosaminoglycan is a hyaluronic acid.6. The aqueous solution according to claim 1 , wherein said aqueous solution is processed by freeze-drying to obtain a dry form of said N-hydroxysuccinimide carboxy polysaccharide active ester.7. A pharmaceutical composition ...

METHOD FOR PRODUCING HYDROGELS

The present invention provides a method of producing a polymer hydrogel comprising the steps of: (1) preparing an aqueous solution of a water soluble polysaccharide derivative and a polycarboxylic acid; (2) optionally agitating the solution, for example, by stirring; (3) isolating a polysaccharide derivative/polycarboxylic acid composite from the solution; and (4) heating the polysaccharide derivative/polycarboxylic acid composite at a temperature of at least about 80° C., thereby cross-linking the polysaccharide with the polycarboxylic acid. The invention also provides polymer hydrogels produced by the methods of the invention. 1. A method for producing a polymer hydrogel , comprising the steps of: (a) preparing an aqueous solution of a water soluble polysaccharide derivative and an amount of polycarboxylic acid less than about 0.5% by weight relative to the weight of the polysaccharide derivative; (b) agitating the solution; (c) isolating a polysaccharide derivative/polycarboxylic acid composite from the solution; and (d) heating the polysaccharide derivative/polycarboxylic acid composite at a temperature of at least about 80° C. , thereby cross-linking the polysaccharide with the polycarboxylic acid.2. The method of claim 1 , wherein the polysaccharide/polycarboxylic acid composite is granulated prior to conducting step (d).3. The method of claim 1 , wherein the polysaccharide derivative is present in the solution of step (a) at a concentration of about 4% or greater 8% by weight relative to water.4. The method of claim 1 , wherein the polycarboxylic acid is present in the solution of step (a) at a concentration of about 0.3% or less by weight relative to the weight of the polysaccharide derivative.5. The method of claim 1 , wherein the polycarboxylic acid is present in the solution of step (a) at a concentration of about 0.05% to about 0.3% by weight relative to the polysaccharide derivative.6. The method of claim 3 , wherein the polysaccharide derivative is ...

APTAMER BIOCONJUGATE DRUG DELIVERY DEVICE

A delivery device for an active agent comprises nanoparticles based on a biopolymer such as starch. The delivery device may also be in the form of an aptamer-biopolymer-active agent conjugate wherein the aptamer targets the device for the treatment of specific disorders. The nanoparticles may be made by applying a high shear force in the presence of a crosslinker. The particles may be predominantly in the range of 50-150 nm and form a colloidal dispersion of crosslinked hydrogel particles in water. The biopolymer may be functionalized. The aptamer may be conjugated directly to the cross-linked biopolymers. The active agent may be a drug useful for the treatment of cancer. The delivery device survives for a period of time in the body sufficient to allow for the sustained release of a drug and for the transportation and uptake of the conjugate into targeted cells. However, the biopolymer is biocompatible and resorbable. 1. A medicament comprising ,a) nanoparticles comprising a mass of crosslinked polymers, at least 50% of the polymers being high molecular weight starch; and,b) active agent molecules conjugated with the nanoparticles.2. The medicament of wherein the nanoparticles have a number average size in the range of 50-150 nm when measured by any of SEM claim 1 , NTA or DLS.3. The medicament of wherein most of the nanoparticles have a size in the range of 50-150 nm when measured by any of SEM claim 2 , NTA or DLS.4. The medicament of wherein the active agent comprises a drug.5. The medicament of wherein the the drug is a chemotherapeutic drug.6. The medicament of wherein the zeta potential of the nanoparticles is negative.7. The medicament of wherein the nanoparticles further comprises ligands conjugated to the cross-linked starch ploymers.8. The medicament of wherein the ligands are aptamers.9. A method of making a medicament comprising the steps of claim 7 ,a) forming a plurality of nanoparticles, the nanoparticles comprising a mass of crosslinked polymers, at ...

Dermal filler compositions

The present invention provides highly injectable, long-lasting hyaluronic acid-based hydrogel dermal filler compositions made with a di-amine or multiamine crosslinker in the presence of a carbodiimide coupling agent.

SIALIC ACID DERIVATIVES

An amine or hydrazide derivative of a sialic acid unit, e.g. in a polysaccharide, is reacted with a bifunctional reagent at least one of the functionalities of which is an ester of N-hydroxy succinimide, to form an amide or hydrazide product. The product has a useful functionality, which allows it to be conjugated, for instance to proteins, drugs, drug delivery systems or the like. The process is of particular utility for derivatising amine groups introduced in sialic acid terminal groups of polysialic acids. 122-. (canceled)25. A compound according to wherein Ris selected from the group consisting of alkanediyl claim 23 , arylene claim 23 , alkarylene claim 23 , heteroarylene and alkylheteroarylene claim 23 , any of which is optionally interrupted by carbonyl claim 23 , ester claim 23 , sulfide claim 23 , ether claim 23 , amide and/or amine linkages.26. A compound according to wherein Ris C-Calkanediyl.27. A compound according to claim 23 , wherein Ris an oligo or poly-saccharide.2838-. (canceled)39. A compound according to wherein Ris selected from the group consisting of alkanediyl claim 24 , arylene claim 24 , alkarylene claim 24 , heteroarylene and alkylheteroarlene claim 24 , any of which is optionally interrupted by carbonyl claim 24 , ester claim 24 , sulfide claim 24 , ether claim 24 , amide and/or amine linkages.40. A compound according to wherein Ris Calkanediyl.41. A compound according to wherein Ris oligo- or poly-sialic acid.42. A compound according to wherein R′ is an oligo- or poly-sialic acid.45. The compound according to claim 23 , wherein is substituted alkarylene.48. The compound according to claim 24 , wherein Ris substituted alkarylene. This application is a divisional of U.S. application Ser. No. 11/660,128 having an international filing date of 12 Aug. 2005, which is the national phase of PCT application PCT/GB2005/003160 having an international filing date of 12 Aug. 2005, which claims priority from European application EP 05251015.3 filed ...

GRAIN MILLING PROCESS

A modification is described of a dry grind process for producing ethanol and other co-products from whole grain, whereby the mash is thermochemically treated by cooking the mash in the presence of an organic acid. The organic acid effectively hydrolyzes both the starch and hemicellulosic components in the milled corn to provide fermentable sugars from both the endosperm and other parts of the kernel, without, however, also producing fermentation-inhibiting levels of other known products of the acid hydrolysis of hemicellulosic materials, such as hydroxymethylfurfural (HMF) and furfural. Further, the organic acid is able to solubilize both the starch and the more recalcitrant hemicelluloses while only partially hydrolyzing the same, so that most of the starch and hemicelluloses are hydrolyzed to oligomers and the amount of chemically labile and reducing sugars is kept sufficiently low as to also not appreciably interfere with the fermentation to ethanol. 1. An improved grain milling process including the production of ethanol by fermentation , comprising:grinding a whole grain;forming a slurry with water of the ground whole grain;adding one or more enzymes and one or more organic acids to the slurry with heating to liquefy fermentable components of the ground whole grain and produce a mash;adding an enzyme to the mash to form a fermentation medium for producing ethanol; andfermenting the fermentation medium in the presence of yeast and one or more added enzymes.2. A process as described in claim 1 , wherein the one or more organic acids are added in the form of a solution of acetic acid claim 1 , formic acid or a combination of acetic and formic acids in water.3. A process as described in claim 2 , wherein the aqueous organic acid solution is 50 percent or more by weight of acid.4. A process as described in claim 3 , wherein the aqueous acid solution is from 50 to 70 percent by weight acid in water.54. A process as defined in any of - claims 1 , further comprising an ...

POLYAMINE-CONTAINING POLYMERS AND METHODS OF SYNTHESIS AND USE

The present invention relates to polyamine-containing polymers and methods of their synthesis and use. The polymer may be hydroxyethylcellulose, dextran, poly(vinyl alcohol) or poly(methyl acrylate). 1. A method of transfecting a cell with a nucleic acid , comprising contacting the cell with a composition comprising (1) a compound comprising a carbon polymer and one or more polyamine groups , wherein the carbon polymer is selected from the group consisting of hydroxyethylcellulose , dextran , poly(vinyl alcohol) and poly(methyl acrylate); and (2) a nucleic acid.2. A method of introducing an exogenous nucleic acid into a cell , comprising contacting the cell with a composition comprising (1) a compound comprising a carbon polymer and one or more polyamine groups , wherein the carbon polymer is selected from the group consisting of hydroxyethylcellulose , dextran , poly(vinyl alcohol) and poly(methyl acrylate); and (2) a nucleic acid.3. The method of wherein the method is in vitro claim 2 , ex vivo or in vivo. This application is a divisional application of U.S. application Ser. No. 13/078,347 filed Apr. 1, 2011, which claims priority upon U.S. provisional application Ser. No. 61/320,355, filed Apr. 2, 2010. These applications are hereby incorporated by reference in their entireties.The present invention relates to compounds comprising carbon polymers and one or more polyamine groups.Nucleic acids encoding biologically active polypeptides or nucleic acids may be transferred to a cell by any of several methods, including viral vectors and chemical transfection. The choice of technique is a balance between the need to incorporate the nucleic acid efficiently, minimizing impact on the short term, and preferably the long term, survival of the cell, and without compromising the genetic makeup of the cell.Aminated, cationic polymers that interact with the nucleic acid and are then taken up by the cell may be advantageous, at least, by avoiding some of the immunological and ...

POLYAMINE-CONTAINING POLYMERS AND METHODS OF SYNTHESIS AND USE

The present invention relates to polyamine-containing polymers and methods of their synthesis and use. The polymer may be hydroxyethylcellulose, dextran, poly(vinyl alcohol) or poly(methyl acrylate). 1a. combining the carbon polymer comprising an hydroxyl group with carbonyldiimidazole to afford an activated oxygen; andb. reacting the activated oxygen with a polyamine to afford a carbamate linkage between the polymer and polyamine.. A method of preparing a compound comprising a carbon polymer and one or more polyamine groups, wherein the carbon polymer is selected from the group consisting of hydroxyethylcellulose, dextran, poly(vinyl alcohol) and poly(methyl acrylate), and the carbon polymer comprises an hydroxyl group, comprising: This application is a divisional application of U.S. application Ser. No. 13/078,347 filed Apr. 1, 2011, which claims priority upon U.S. provisional application Ser. No. 61/320,355, filed Apr. 2, 2010. These applications are hereby incorporated by reference in their entireties.The present invention relates to compounds comprising carbon polymers and one or more polyamine groups.Nucleic acids encoding biologically active polypeptides or nucleic acids may be transferred to a cell by any of several methods, including viral vectors and chemical transfection. The choice of technique is a balance between the need to incorporate the nucleic acid efficiently, minimizing impact on the short term, and preferably the long term, survival of the cell, and without compromising the genetic makeup of the cell.Aminated, cationic polymers that interact with the nucleic acid and are then taken up by the cell may be advantageous, at least, by avoiding some of the immunological and mutagenic concerns that accompany some viral transformation systems. DEAE-dextran is an example of an aminated polymer that is relatively non-toxic, however, the efficiency may be low. Polyethyleneimine (PEI) (Boussif, et al., 19951995, 95, 7297-7301) has a high cationic charge ...

CROSSLINKING SYSTEMS FOR HYDROXYL POLYMERS

Crosslinking systems suitable for use in a polymer melt composition wherein the polymer melt composition comprises a hydroxyl polymer; polymeric structures made from such polymer melt compositions; and processes/methods related thereto are provided. 1. A polymeric structure comprising a plurality of crosslinked hydroxyl polymer fibers , wherein the hydroxyl polymer is selected from the group consisting of: starch , starch derivatives , and mixtures thereof , wherein the polymeric structure exhibits an initial total wet tensile of at least 1.18 g/cm.2. The polymeric structure according to wherein the polymeric structure exhibits an initial total wet tensile of at least 1.57 g/cm.3. The polymeric structure according to wherein the polymeric structure exhibits an initial total wet tensile of at least 1.97 g/cm.4. The polymeric structure according to wherein the polymeric structure further comprises a polymer selected from the group consisting of: polyvinyl alcohol claim 1 , chitosan claim 1 , chitosan derivatives claim 1 , cellulose derivatives claim 1 , gums claim 1 , arabinans claim 1 , galactans and mixtures thereof.5. The polymeric structure according to wherein the hydroxyl polymer has a weight average molecular weight of from about 10 claim 1 ,000 to about 40 claim 1 ,000 claim 1 ,000 g/mol.6. The polymeric structure according to wherein the crosslinking system further comprises a crosslinking facilitator.7. The polymeric structure according to wherein the crosslinking facilitator comprises an acid having a pKa of between 2 and 6 or a salt thereof.8. The polymeric structure according to wherein the acid comprises a Bronsted Acid.9. The polymeric structure according to wherein the salt comprises an ammonium salt.10. The polymeric structure according to wherein the crosslinking facilitator is selected from the group consisting of: acetic acid claim 6 , benzoic acid claim 6 , citric acid claim 6 , formic acid claim 6 , phosphoric acid claim 6 , succinic acid claim 6 ...

Glucosamine materials

Polymers comprising glucosamine (GlcN) are used to make medical devices. Examples include polyGlcN and carrier molecules containing multiple GlcN residues.

Method of modulating release of biomolecules having heparin-binding affinity

The present invention relates to a method of modulating a release of biomolecules having heparin-binding affinity, and more specifically, to a method of modulating a release of biomolecules having heparin-binding affinity, using thiolated heparin adsorbed on metal surface. According to the present invention, it is possible to modulate various biomolecules having heparin-binding affinity such as growth factors spatiotemporally by external electrical stimulations, without causing cytotoxicity and having deteriorating effects on cell activity. Thus, the present invention can be applied for various biomedical and biotechnical fields including drug delivery, biosensor, and cell culture.

Method for producing biobased chemicals from woody biomass

A method for utilizing woody biomass components, namely cellulose, hemicellose, and lignin, and converting them to value-added biobased chemical products is described herein. The present method provides treatments to obtain a plurality of component streams from woody biomass for producing derivative products while minimizing waste products.

Methods of making hyaluronic acid/collagen compositions

Hyaluronic acid and collagen may be crosslinked in aqueous solution as described herein. The crosslinked macromolecular matrices obtained in this process may be used as a hydrogel for implants and fillers for human aesthetic and therapeutic products.

CELLULOSE INTERPOLYMERS AND METHOD OF OXIDATION

This invention provides cellulose ester interpolymers, and methods of oxidizing cellulose interpolymers and cellulose ester interpolymers. The invention also provides routes to access carboxylated cellulose ester derivatives with high acid numbers wherein the carboxyl group is attached directly to the cellulose backbone by a carbon-carbon bond. Through functionalization of an intermediate aldehyde, the corresponding cationic or zwitterionic cellulose ester derivatives can also be accessed. The interpolymers of the present invention have a number of end-use applications, for example, as binder resins in various types of coating compositions and as drug delivery agents. 1. A method for preparing a stable form of a cellulose formate ester interpolymer comprising:{'sub': 2', '12, '(1) mixing formic acid, water, and an C-Cacyl anhydride to form a mixed anhydride mixture at a first contact temperature;'}(2) contacting the mixed anhydride mixture and a cellulose compound to form a reaction mixture at a second contact temperature;(3) adding an acid catalyst to the reaction mixture;(4) passing of a formylation period; 'a resulting cellulose formate ester interpolymer has a degree of substitution per anhydroglucose unit of formate of about 0.5 to about 1.5.', 'wherein'}2. The method of claim 1 , wherein the resulting cellulose formate ester interpolymer has a degree of substitution per anhydroglucose unit of formate of about 0.7 to about 1.2.3. The method of claim 1 , wherein the resulting cellulose formate ester interpolymer has a degree of substitution per anhydroglucose unit of formate of about 0.9 to about 1.1.4. The method of claim 1 , wherein the acid catalyst is sulfuric acid.5. The method of claim 1 , wherein the acid catalyst is added in an amount ranging from about 0.25 to about 15 weight percent based on weight of cellulose compound.6. The method of claim 1 , wherein the amount of formic acid added in step (1) is from about 4 to about 15 molar equivalents based on ...

CELLULOSE INTERPOLYMERS AND METHOD OF OXIDATION

This invention provides cellulose ester interpolymers, and methods of oxidizing cellulose interpolymers and cellulose ester interpolymers. The invention also provides routes to access carboxylated cellulose ester derivatives with high acid numbers wherein the carboxyl group is attached directly to the cellulose backbone by a carbon-carbon bond. Through functionalization of an intermediate aldehyde, the corresponding cationic or zwitterionic cellulose ester derivatives can also be accessed. The interpolymers of the present invention have a number of end-use applications, for example, as binder resins in various types of coating compositions and as drug delivery agents. 1. A method for converting a primary alcohol to a formyl , carboxylate , or mixture thereof , comprising: 'the mixture has a pH of less than about 4 and comprises a compound comprising a primary alcohol functional group;', 'wherein'}, 'adding a 4-substituted piperidine nitroxyl derivative wherein the substitutent is capable of hydrogen bonding, a primary oxidant, and a terminal oxidant to a mixture to form a reaction mixture,'}passing of a reaction period sufficient to effect conversion of the primary alcohol functional group.2. The method of claim 1 , wherein the primary alcohol is a group on a polysaccharide selected from starch esters and other polysaccharides esters having α-1 claim 1 ,4 glycosidic linkages claim 1 , pullulan esters and other polysaccharides esters having α-1 claim 1 ,3 glycosidic linkages claim 1 , cellulose esters and other polysaccharides esters having β-1 claim 1 ,4 glycosidic linkages claim 1 , and other β-glucan esters selected from chitin claim 1 , chitosan claim 1 , fructans claim 1 , glactomannans claim 1 , glucomannas claim 1 , xyloglucans claim 1 , and arabinoxylans.3. The method of claim 1 , wherein the primary oxidant is a Mn(III) salt.4. The method of claim 3 , wherein the Mn salt is or manganese triacetate.5. The method of claim 1 , wherein the primary oxidant ...

Cellulose interpolymers and method of oxidation

This invention provides cellulose ester interpolymers, and methods of oxidizing cellulose interpolymers and cellulose ester interpolymers. The invention also provides routes to access carboxylated cellulose ester derivatives with high acid numbers wherein the carboxyl group is attached directly to the cellulose backbone by a carbon-carbon bond. Through functionalization of an intermediate aldehyde, the corresponding cationic or zwitterionic cellulose ester derivatives can also be accessed. The interpolymers of the present invention have a number of end-use applications, for example, as binder resins in various types of coating compositions and as drug delivery agents.

DERMAL FILLER COMPOSITIONS INCLUDING ANTIOXIDANTS

Provided are injectable, hyaluronic acid-based hydrogel compositions including conjugated vitamins. 1. An injectable dermal filler comprising:hyaluronic acid; and 'wherein a degree of conjugation is between about 3 mol % and about 40 mol %.', 'a vitamin C derivative covalently conjugated to the hyaluronic acid;'}2. The dermal filler of wherein the hylauronic acid is crosslinked with Star-PEG epoxide.3. The dermal filler of wherein the hyaluronic acid is crosslinked with Star-PEG amine.4. The dermal filler of wherein the hyaluronic acid is crosslinked with BDDE.5. The dermal filler of wherein and the degree of conjugation is between about 3 mol % and about 15 mol %.6. The dermal filler of wherein vitamin C derivative is AA2G.7. The dermal filler of wherein the vitamin C derivative is Vitagen.8. The dermal filler of wherein the vitamin C derivative is AA2P.9. The dermal filler of used in treating a skin defect wherein claim 1 , when introduced into the skin of a human being claim 1 , releases ascorbic acid into the human being for at least about 1 month and up to about 20 months.10. An injectable dermal filler comprising:hyaluronic acid crosslinked with Star PEG amine and having a degree of conjugation of between about 3 mol % and about 40 mol %; and 'wherein the dermal filler, when introduced into the skin of a human being, releases ascorbic acid into the human being for at least about 1 months and up to about 20 months.', 'AA2P covalently conjugated to the hyaluronic acid'}11. A method of making a dermal filler comprising the steps of:providing hyaluronic acid;reacting a crosslinking agent with a Vitamin C derivative;adding the reacted crosslinking agent and Vitamin C derivative to the hyaluronic acid to form a crosslinked hyaluronic acid composition including covalently conjugated Vitamin C; andhomogenizing and neutralizing the crosslinked hyaluronic acid composition to obtain an injectable gel having a conjugation degree of between about 3 mol % and about 40 mol ...

Modified starch material of biocompatible hemostasis

A modified starch material for biocompatible hemostasis, biocompatible adhesion prevention, tissue healing promotion, absorbable surgical wound sealing and tissue bonding, when applied as a biocompatible modified starch to the tissue of animals. The modified starch material produces hemostasis, reduces bleeding of the wound, extravasation of blood and tissue exudation, preserves the wound surface or the wound in relative wetness or dryness, inhibits the growth of bacteria and inflammatory response, minimizes tissue inflammation, and relieves patient pain. Any excess modified starch not involved in hemostatic activity is readily dissolved and rinsed away through saline irrigation during operation. After treatment of surgical wounds, combat wounds, trauma and emergency wounds, the modified starch hemostatic material is rapidly absorbed by the body without the complications associated with gauze and bandage removal.

PROCESS FOR MODIFYING THE PROPERTIES OF CITRUS PULP

A process is disclosed for modifying citrus fiber. Citrus fiber is obtained having a c* close packing concentration value of less than 3.8 w %, anhydrous basis. The citrus fiber can have a viscosity of at least 1000 mPa·s, wherein said citrus fiber is dispersed in standardized water at a mixing speed of from 800 rpm to 1000 rpm, to a 3 w/w % citrus fiber/standardized water solution, and wherein said viscosity is measured at a shear rate of 5 s−1 at 20 C. Citrus fiber can be obtained having a CIELAB L* value of at least 90. The citrus fiber can be used in food products, feed products, beverages, personal care products, pharmaceutical products or detergent products. 118.-. (canceled)19. A method of modifying the characteristics of a citrus fiber , the method comprising:a. hydrating the citrus fiber;b. treating the hydrated citrus fiber to obtain a homogenized citrus fiber;c. washing the homogenized citrus fiber with an organic solvent to obtain organic solvent washed citrus fiber;d. desolventizing and drying the organic solvent washed citrus fiber; ande. recovering modified citrus fiber therefrom.20. The method of claim 19 , wherein said citrus fiber is obtained from the group consisting of citrus pulp claim 19 , citrus peel claim 19 , citrus rag claim 19 , and combinations thereof.21. The method of claim 19 , wherein the viscosity of the modified citrus fiber is increased by at least 100% claim 19 , wherein the citrus fiber is dispersed in standardized water at a mixing speed of from 800 rpm to 1000 rpm claim 19 , to a 3 w/w % citrus fiber/standardized water solution claim 19 , and wherein the viscosity is measured at a shear rate of 5 sat 20° C.22. The method of claim 19 , wherein treating comprises pressure homogenization using a pressure of from 50 bar to 1000 bar.23. The method of claim 22 , wherein treating is a single-pass pressure homogenization using a pressure of from 300 bar to 1000 bar.24. The method of claim 22 , wherein treating is a multi-pass pressure ...

GUAR GUM CONTAINING COMPOUNDS

Disclosed is a compound having the following structure: 2. The compound of claim 1 , wherein Xthough Xare each —H.3. The compound of claim 1 , further comprised in a cosmetic composition.4. The compound of claim 3 , wherein the cosmetic composition is a mascara claim 3 , an eyeliner claim 3 , or a lipstick. This application is a continuation of U.S. application Ser. No. 13/449,239, filed Apr. 17, 2012, which is a continuation of U.S. application Ser. No. 13/219,324, filed Aug. 26, 2011 (now issued as U.S. Pat. No. 8,158,113), which is a continuation application of U.S. application Ser. No. 12/144,342 (now issued as U.S. Pat. No. 8,029,771), filed Jun. 23, 2008, which claims the benefit of U.S. Provisional Application No. 60/947,199, filed Jun. 29, 2007. The contents of the referenced applications are incorporated by reference.A. Field of the InventionThe present invention relates generally to a compound that can be used as a dispersing agent or suspending agent in compositions. The compound can include a guar gum backbone that has selected groups attached to the backbone.B. Description of Related ArtCosmetic compositions come in a wide variety of colors or shades. This variety is often exhibited in products such as lipsticks, eyeliners, mascara, and blushes. Colorants such as pigments can be used to create these different colors or shades.A problem associated with the use of colorants is that they tend to agglomerate together in a composition. This agglomeration can cause the color of the composition to appear blotchy. One attempt to solve this agglomeration problem is to either treat the surface of the colorants or add a compound to the composition that interacts with the colorant to more efficiently disperse the colorant throughout the composition. Although these type of treatments and compounds have been shown to decrease agglomeration, such treatments and compounds oftentimes inefficiently disperse such colorants. This can cause the composition to have a streaky ...

Method of treating plant biomass

Plant biomass is immersed in a solution that contains a polar solvent and an imidazolium salt that has a melting point of at least 100° C. As a result, the cellulose and hemicellulose present in the plant biomass are relaxed (decrystallized and depolymerized) and brought into an easy-to-degrade state. Reacting the immersed plant biomass with a cellulase produces saccharide at a high conversion efficiency.

Compositions Comprising High Molecular Weight Hyaluronic Acid and Methods For Producing Same

This invention provides cell culture compositions which produce significant quantities of high molecular weight hyaluronic acid. The cell cultures are obtained from cells of mole rats, such as naked mole rats and blind mole rats. The high molecular weight hyaluronic acid can be collected in the conditioned media of these cell cultures. These cell cultures provide a convenient source of large quantities of high molecular weight hyaluronic acid.

GALACTOSE-PRONGED POLYSACCHARIDES IN A FORMULATION FOR ANTIFIBROTIC THERAPIES

Methods and compositions for reducing fibrosis and cirrhosis are provided in which an effective dose of an admixture of a polysaccharide compound and, for example, a compound selected from the group consisting of antibodies specific to intracellular or cell-surface: (i) beta-PDGF receptors; (ii) synaptophysin; (iii) zvegf3; (iv) CCR1 receptors; (v) connective tissue growth factor; (vi) alpha 1-smooth muscle actin; (vii) matrix metalloproteinases MMP 2 and MMP9; (viii) matrix metalloproteinase inhibitors TIMP1 and TMP2; (ix) integrins; (x) TFG-β1; (xi) endothelin receptor antagonists; and (xii) collagen synthesis and degradation modulating compounds; (xiii) actin synthesis and degradation modulating compounds; and (xiv) tyrosine kinases is administered to an animal in order to treat fibrosis. 1. A composition comprising an effective amount of a modified galacto-rhamnogalacturonan compound and an acceptable pharmaceutical carrier ,wherein the modified galacto-rhamnogalacturonan compound is a branched heteropolymer having a backbone of alternating α-1,2 linked rhamnose and α-1,4-linked GalA residues that carries neutral side-chains of predominantly 1,4-β-D-galactose and/or 1,5-α-L-arabinose residues attached to the rhamnose residues of the backbone, andwherein the galacto-rhamnogalacturonan compound is modified by demethoxylation, deacetylation or depolymerization;wherein the effective amount of the modified galacto-rhamnogalacturonan, when administered in a subject having at least one of the following: chronic kidney disease associated with the development of fibrosis, established kidney fibrosis, or cirrhosis, is capable of inhibiting or slowing down of the progression of kidney fibrosis or cirrhosis or reduction of established kidney fibrosis or cirrhosis;wherein the modified galacto-rhamnogalacturonan compound wherein, when the galacto-rhamnogalacturonan compound is utilized to treat LX2 immortalized human hepatic stellate cells in a MTT cell viability assay, the ...

Process for obtaining citrus fiber from citrus pulp

A process is disclosed for obtaining citrus fiber from citrus pulp. Citrus fiber is obtained having a c* close packing concentration value of less than 3.8. The citrus fiber can be obtained having a viscosity of at least 1000 mPa·s, wherein said citrus fiber is dispersed in standardized water at a mixing speed of from 800 rpm to 1000 rpm, to a 3 w/w % citrus fiber/standardized water solution, and wherein said viscosity is measured at a shear rate of 5 s−1 at 20° C. Citrus fiber can be obtained having a CIELAB L* value of at least 90. The citrus fiber can be used in food products, feed products, beverages, personal care products, pharmaceutical products or detergent products.

Cyclodextrin-based polymers for therapeutics delivery

The present invention relates to novel compositions of therapeutic cyclodextrin containing polymeric compounds designed as a carrier for small molecule therapeutics delivery and pharmaceutical compositions thereof. These cyclodextrin-containing polymers improve drug stability and solubility, and reduce toxicity of the small molecule therapeutic when used in vivo. Furthermore, by selecting from a variety of linker groups and targeting ligands the polymers present methods for controlled delivery of the therapeutic agents. The invention also relates to methods of treating subjects with the therapeutic compositions described herein. The invention further relates to methods for conducting pharmaceutical business comprising manufacturing, licensing, or distributing kits containing or relating to the polymeric compounds described herein.

LIGANDS FOR ANTIBODY AND Fc-FUSION PROTEIN PURIFICATION BY AFFINITY CHROMATOGRAPHY

The present invention relates to the use for affinity purification of an antibody or an fragment of an antibody, of a ligand-substituted matrix comprising a support material and at least one ligand covalently bonded to the support material, the ligand being represented by formula (I) 2. The use of wherein Aris phenylene claim 1 , preferably methoxy-substituted phenylene.3. The use of wherein the C═O and the NH group are bonded to Arin meta position to each other.4. The use of wherein the 5- or 6-membered heterocyclic aromatic ring of Aris attached to the C═O group via a carbon ring atom which is adjacent to a ring heteroatom claim 1 , preferably a nitrogen or oxygen atom.5. The use of wherein the 5- or 6-membered heterocyclic aromatic ring of Arcontains two or more nitrogen atoms or one or more nitrogen atoms and an oxygen atom.6. The use of wherein the 5- or 6-membered heterocyclic aromatic ring of Aris N-methyl-substituted pyrazole claim 5 , pyridine claim 5 , isoxazole or oxadiazole.7. The use according to wherein the support material comprises a material selected from carbohydrates or crosslinked carbohydrates claim 1 , preferably agarose claim 1 , cellulose claim 1 , dextran claim 1 , starch claim 1 , alginate and carrageenan claim 1 , Sepharose claim 1 , Sephadex; synthetic polymers claim 1 , preferably polystyrene claim 1 , styrene-divinylbenzene copolymers claim 1 , polyacrylates claim 1 , PEG-Polycacrylate copolymers polymethacrylates claim 1 , polyvinyl alcohol claim 1 , polyamides and perfluorocarbons; inorganic materials claim 1 , preferably glass claim 1 , silica and metal oxides; and composite materials.8. The use according to wherein the protein is an antibody claim 1 , preferably an IgG type antibody claim 1 , or an Fc fusion protein.9. The use of wherein the purification is attained by binding of the ligand of the ligand-substituted matrix to an Fc fragment or domain of the antibody or the fusion protein.10. The use according to wherein the Fc ...

METHOD FOR PRODUCTION OF CELLULOSE NANO CRYSTALS FROM CELLULOSE-CONTAINING WASTE MATERIAL

A process is disclosed for recovering pure cellulose from a cellulose-containing sludge, the process comprising treating a sludge cellulose source under conditions permitting dissolution of non-cellulose material and suspension of the cellulose, wherein said dissolution conditions do not alter cellulose morphology. 1. A process for recovering pure cellulose from a cellulose-containing sludge , the process comprising treating a sludge cellulose source under conditions permitting dissolution of non-cellulose material and suspension of the cellulose , wherein said dissolution conditions do not alter cellulose morphology.2. The process according to claim 1 , wherein said sludge cellulose source contains between about 5% and about 60% cellulose claim 1 , or between about 40% and about 60% cellulose.3. The process according to claim 1 , wherein said sludge cellulose source is paper mill sludge.47-. (canceled)8. The process according to claim 1 , for the removal of about 95% claim 1 , by weight claim 1 , of calcium carbonate from the sludge cellulose source.9. (canceled)10. (canceled)11. The process according to claim 1 , wherein said conditions permitting dissolution of a non-cellulose material and suspension of the cellulose include treatment of said sludge cellulose source with a dilute acid.12. The process according to claim 11 , wherein the dilute acid having a concentration of between 0.1M and 1M acid.1317-. (canceled)18. The process according to claim 11 , wherein the acid concentration is between 0.1M and 0.3M.19. The process according to claim 11 , wherein said acid is selected from organic and inorganic acids claim 11 , said acid does not form water-insoluble salts with calcium carbonate.20. The process according to claim 19 , wherein said acid is selected from HCl claim 19 , HBr claim 19 , HPO claim 19 , and HNO.21. (canceled)22. (canceled)23. The process according to claim 20 , wherein said acid is HCl.2431-. (canceled)32. The process according to claim 11 , ...

NOVEL POLYMER AND PROCESS FOR PRODUCING THE SAME

An objective of the invention is to provide an excellent biomaterial having a good operability and a high safety; the solution is a polymer having one or more peptide units represented by formula (1) as described below and one or more saccharide residues derived from polysaccharides: 2. The polymer according to claim 1 , comprising a triple helical structure.3. The polymer according to claim 1 , wherein a weight ratio of the peptide unit(s) to the saccharide residue(s) is in the range of 95/5 to 50/50.4. The polymer according to claim 1 , wherein the polysaccharides are selected from hyaluronic acid claim 1 , carboxylmethyl cellulose claim 1 , chondroitin sulfate claim 1 , dextran claim 1 , heparin and dermatan sulfate.5. The polymer according to claim 1 , further having one or more amino acid residues or one or more peptide units claim 1 , in addition to the peptide unit(s).6. The polymer according to claim 5 , wherein the further amino acid residue(s) is/are a glycine residue(s) or a lysine residue(s).7. The polymer according to claim 1 , wherein the peptide unit and the saccharide residue derived from the polysaccharides are bonded between a carboxyl group thereof and an amino group thereof.8. A process for producing the polymer according to claim 1 , comprising a step for allowing a condensation reaction between a peptide oligomer including the peptide unit represented by formula (1) and the polysaccharides. This is a Non-Provisional application, which claims priority to Japanese Patent Application No. 2011-261127, filed on Nov. 30, 2011; the contents of which are all herein incorporated by this reference in their entireties. All publications, patents, patent applications, databases and other references cited in this application, all related applications referenced herein, and all references cited therein, are incorporated by reference in their entirety as if restated here in full and as if each individual publication, patent, patent application, database or ...

NUCLEIC ACID/ POLYSACCHARIDE COMPLEX

An object of the present invention is to provide a highly stable nucleic acid-polysaccharide complex of an siRNA and schizophyllan. A nucleic acid-polysaccharide complex is formed by adding polydeoxyadenine in which at least part of the phosphodiester link portion is phosphorothioated to an siRNA and allowing the siRNA and schizophyllan to form a complex. 1. A nucleic acid-polysaccharide complex of schizophyllan and a polynucleotide ,the polynucleotide containing an siRNA to which polydeoxyadenine is added,the siRNA being directed to a target gene, andthe polydeoxyadenine having phosphodiester links that are at least partially phosphorothioated.2. The nucleic acid-polysaccharide complex according to claim 1 , wherein the siRNA is a 21 mer type claim 1 , and the polynucleotide contains polydeoxyadenine that has phosphodiester links at least partially phosphorothioated and that is added to a sense strand of the siRNA.3. The nucleic acid-polysaccharide complex according to claim 1 , wherein the polydeoxyadenine has 30 to 50 nucleotides.4. The nucleic acid-polysaccharide complex according to claim 1 , wherein at least 50% of the phosphodiester links of the polydeoxyadenine are phosphorothioated.5. The nucleic acid-polysaccharide complex according to claim 1 , wherein the target gene is a gene expressed in a Dectin-1 expressing cell.6. The nucleic acid-polysaccharide complex according to claim 1 , wherein the target gene is a costimulatory factor expressed in a Dectin-1 expressing cell.7. The nucleic acid-polysaccharide complex according to claim 6 , wherein the costimulatory factor is a CD40 gene.8. A pharmaceutical composition comprising a nucleic acid-polysaccharide complex of .9. A function modulator for a Dectin-1 expressing cell claim 1 , comprising a nucleic acid-polysaccharide complex of .10. The function modulator according to claim 9 , wherein a function of the Dectin-1 expressing cell is an immunomodulatory function.11. An immunomodulator comprising a nucleic ...

COMPLEX OBTAINED FROM HYALURONIC ACID OR A SALT THEREOF AND CHONDROITIN SULPHATE MIXTURES

The present invention relates to a novel complex, obtainable by mixing hyaluronic acid or a salt thereof and chondroitin sulphate or a salt thereof, and forming an aqueous solution of said mixture, which is further subjected to a drying process. The invention also relates to various compositions and formulations comprising the complex of the invention, process for obtaining said complex and uses thereof. 2. The complex according to claim 1 , wherein the hyaluronic acid or a salt thereof has an average molecular weight greater than 1 claim 1 ,200 claim 1 ,000 Daltons.3. The complex according to claim 1 , wherein the weight ratio of hyaluronic acid or a salt thereof to chondroitin sulphate or a salt thereof is from 1:1 to 1:10.4. The complex according to claim 3 , wherein the weight ratio of hyaluronic acid or a salt thereof to chondroitin sulphate or a salt thereof is 1:1.5. A pharmaceutical composition comprising the complex as defined in to be administered by a route selected from the group consisting of parenteral administration claim 1 , oral administration and topical administration.6. The pharmaceutical composition according to claim 5 , wherein the concentration of the complex to be administered parenterally is equal or greater than 20 mg/mL.7. The pharmaceutical composition according to claim 5 , wherein said composition is administered by intra-articular injection.8. The pharmaceutical composition according to claim 5 , wherein the amount of complex to be administered orally is equal or greater than 220 mg.9. The pharmaceutical composition according to claim 5 , wherein the concentration of the complex to be administered topically is equal or greater than 70 mg/mL.10. A pre-filled syringe for intra-articular application comprising the pharmaceutical composition according to .11. An artificial matrix for intra-articular implantation comprising the pharmaceutical composition according to .12. A pharmaceutical composition according to claim 5 , for use in ...

Labeled Alginate Conjugates for Molecular Imaging Applications

Described are bifunctional NOTA-based derivatives capable of conjugating with alginate and with metal ions, as well as NOTA-alginate conjugates which can be labeled with stable or radioactive metal ions. Also described are conjugation methods of the bifunctional NOTA-based linker with alginate, and methods of using radiometal-labeled NOTA-alginate conjugates or other radio-labeled alginate conjugates as imaging reagents. 2. The compound of claim 1 , wherein the compound further comprises a stable or radioactive metal ion chelated by the 1 claim 1 ,4 claim 1 ,7-triazacyclononane-1 claim 1 ,4 claim 1 ,7-triacetic acid moiety.3. The compound of claim 2 , wherein the stable or radioactive metal ion comprises a gallium ion.4. The compound of claim 2 , wherein the radioactive metal ion comprises Cu claim 2 , Cu claim 2 , Cu claim 2 , Cu claim 2 , Cu claim 2 , or In.6. The alginate conjugate of claim 5 , wherein the conjugate further comprises a stable or radioactive metal ion chelated by the 1 claim 5 ,4 claim 5 ,7-triazacyclononane-1 claim 5 ,4 claim 5 ,7-triacetic acid moiety of the conjugate.7. The alginate conjugate of claim 6 , wherein the stable or radioactive metal ion comprises a gallium ion.8. The alginate conjugate of claim 6 , wherein the radioactive metal ion comprises Cu claim 6 , Cu claim 6 , Cu claim 6 , Cu claim 6 , Cu claim 6 , or In.9. A method of imaging in a mammal comprising:administering a radio-labeled alginate conjugate to a mammal; andimaging the temporal and spatial distribution of the radio-labeled alginate conjugate.11. The method of claim 10 , wherein the stable or radioactive metal ion comprises a gallium ion.12. The method of claim 10 , wherein the radioactive metal ion comprises Cu claim 10 , Cu claim 10 , Cu claim 10 , Cu claim 10 , Cu claim 10 , or In.13. The method of claim 9 , wherein the alginate is conjugated to an iodinated tyramine or tyramine derivative.14. The method of claim 9 , wherein the radio-labeled alginate conjugate is ...

PARTICULATE WATER-SOLUBLE POLYMERIC POLYOL TREATED WITH TRIALKYL ORTHOESTERS OR TETRAALKYL ORTHOCARBONATES

The present invention relates to a particulate water-soluble polymeric polyol that is treated with a compound represented by formula (I), CR(OR)(I) wherein Ris selected from hydrogen, a C-Calkyl group and an aryl group, Ris independently at each occurrence selected from a C-Calkyl group and an aryl group, and x is selected from the integer 0 and 1; or with a combination of said compounds, to a method for treating a particulate water-soluble polymeric polyol with the above compound and to a method for the preparation of an aqueous solution of the treated particulate water-soluble polymeric polyol. 2. The particulate water-soluble polymeric polyol of wherein the water-soluble polymeric polyol is selected from cellulose ethers claim 1 , cellulose esters claim 1 , starch ethers claim 1 , starch esters claim 1 , modified starches claim 1 , vegetable gums claim 1 , alginates claim 1 , poly(vinyl alcohol)s claim 1 , partially etherified poly(vinyl alcohol)s claim 1 , partially esterified poly(vinyl alcohol)s claim 1 , acrylic polyols claim 1 , polyester polyols claim 1 , polyurethane polyols claim 1 , polyether polyols or combinations thereof.3. The particulate water-soluble polymeric polyol of claim 1 , wherein the polymeric polyol comprises a plurality of hydroxyalkyl groups.4. The particulate water-soluble polymeric polyol of claim 1 , wherein the polymeric polyol is selected from hydroxyalkyl cellulose ethers and alkyl hydroxyalkyl cellulose ethers.5. The particulate water-soluble polymeric polyol of claim 1 , wherein the compound represented by formula (I) is non-cyclic.6. The particulate water-soluble polymeric polyol of claim 1 , wherein in the compound represented by formula (I) Ris selected from hydrogen and linear C-C-alkyl and Ris selected from linear C-C-alkyl.7. The particulate water-soluble polymeric polyol of wherein the particulate water-soluble polymeric polyol is surface-treated with 10 to 200 claim 1 ,000 wppm of compound represented by formula (I) based ...

Treatment of surfactant laden wastewater

Clarification of surfactant laden wastewaters of the type commonly encountered in the laundry, dishwashing, textile manufacturing, and metal cleaning and degreasing processes is provided by use of a chitosan/(meth)acrylyloxy alkyl quaternary ammonium salt graft polymer.

Cyclodextrin-based polymers for therapeutics delivery

The present invention relates to novel compositions of therapeutic cyclodextrin containing polymeric compounds designed as a carrier for small molecule therapeutics delivery and pharmaceutical compositions thereof. These cyclodextrin-containing polymers improve drug stability and solubility, and reduce toxicity of the small molecule therapeutic when used in vivo. Furthermore, by selecting from a variety of linker groups and targeting ligands the polymers present methods for controlled delivery of the therapeutic agents. The invention also relates to methods of treating subjects with the therapeutic compositions described herein. The invention further relates to methods for conducting pharmaceutical business comprising manufacturing, licensing, or distributing kits containing or relating to the polymeric compounds described herein.

ANTICOAGULANT-CONJUGATED CARBON NANOCAPSULE, ANTITHROMBOTIC AGENT CONTAINING THEREOF

The embodiments provide a carbon nanocapsule conjugated with at least one of the anticoagulants on the surface and an antithrombotic drug containing the anticoagulant-conjugated carbon nanocapsule as an active ingredient. The anticoagulant-conjugated carbon nanocapsule has less cytotoxicity and good biocompatibility. A method for preparing the anticoagulant-conjugated carbon nanocapsule is also provided. 1. A carbon nanocapsule conjugated with at least one of anticoagulants on a surface thereof.2. The carbon nanocapsule as claimed in claim 1 , wherein the carbon nanocapsule has a diameter of 3˜100 nm.3. The carbon nanocapsule as claimed in claim 1 , wherein the carbon nanocapsule is hollow.4. The carbon nanocapsule as claimed in claim 1 , wherein the carbon nanocapsule is filled with metals claim 1 , metal oxides claim 1 , metal carbides or alloys thereof.5. The carbon nanocapsule as claimed in claim 4 , wherein the metal of the metals claim 4 , metal oxides claim 4 , metal carbides and alloys thereof is selected from a group consisting of Sc claim 4 , V claim 4 , Cr claim 4 , Fe claim 4 , Co claim 4 , Ni claim 4 , Y claim 4 , Zr claim 4 , Mo claim 4 , Ru claim 4 , Pd claim 4 , La claim 4 , Ce claim 4 , Pr claim 4 , Nd claim 4 , Gd claim 4 , Tb claim 4 , Dy claim 4 , Ho claim 4 , Er claim 4 , Tm claim 4 , Lu claim 4 , Ta claim 4 , Os claim 4 , Ir claim 4 , Pt claim 4 , Au claim 4 , Th and U.6. The carbon nanocapsule as claimed in claim 1 , wherein the anticoagulant comprises heparin claim 1 , plasmin claim 1 , serine protease claim 1 , urokinase claim 1 , streptokinase claim 1 , warfarin claim 1 , acenocoumarol claim 1 , phenindione claim 1 , a vitamin K antagonist claim 1 , or a tissue plasminogen activator.7. The carbon nanocapsule as claimed in claim 1 , wherein the carbon nanocapsule surface conjugates with 1˜10anticoagulants.8. The carbon nanocapsule as claimed in claim 1 , wherein the conjugation is via amide bond formation.9. An antithrombotic agent ...

SULFATED POLYSACCHARIDE CAPABLE OF BINDING TO GROWTH FACTOR AND USE THEREOF

A biological substance which can enhance the proliferation and differentiation of cells; a method for evaluating the proliferation and differentiation of cells, which targets the biological substance; a composition for detecting the proliferation and differentiation of cells, which contains a molecule capable of binding to the biological substance; and a composition for enhancing the proliferation and differentiation of cells, which contains the biological substance. A part of a sulfated polysaccharide secreted from cells binds to a growth factor during the course of the proliferation and differentiation of the cells, that the amount of the sulfated polysaccharide capable of the above-mentioned binding and secreted from the cells correlates strongly with the progression of the proliferation and differentiation of the cells, and that the proliferation and differentiation of cells can be evaluated and the proliferation and differentiation of cells can be enhanced utilizing the sulfated polysaccharide. 1. A sulfated polysaccharide secreted from cells during the course of cell proliferation and differentiation that binds to growth factor.2. The sulfated polysaccharide of claim 1 , wherein the course of cell proliferation and differentiation is the course of proliferation and differentiation of osteocytes or chondrocytes.3. The sulfated polysaccharide of claim 1 , wherein the growth factor is BMP-2 or bFGF.4. A method for evaluating cell proliferation and differentiation claim 1 , the method comprising:{'claim-ref': {'@idref': 'CLM-00001', 'claim 1'}, 'detecting the sulfated polysaccharide of .'}5. A composition for detecting cell proliferation and differentiation comprising an active ingredient comprising a molecule that binds to the sulfated polysaccharide of .6. A composition for promoting cell proliferation and differentiation comprising an active ingredient comprising the sulfated polysaccharide of .7. The sulfated polysaccharide of claim 1 , wherein the growth ...

Enterosoluble and intestinal-enzyme-biodegradable materials and method for preparing the same

An enterosoluble and intestinal-enzyme-biodegradable material is provided. The enterosoluble and intestinal-enzyme-biodegradable material includes a modified amylopectin, wherein at least one of hydrogen atoms is replaced by —CO—(CH 2 ) n —COOH (n is 2-4) and the modified amylopectin has an acid value of 35-180 mg KOH/g. The disclosure also provides a method for preparing an enterosoluble and intestinal-enzyme-biodegradable material.

PROCESS FOR RECOVERING SUGARS FROM A PRETREATMENT STREAM OF LIGNOCELLULOSIC BIOMASS

This specification discloses an improved method for conducting the removal of C5 xylan based sugars from biomass. The improved method involves a series of soakings and washings of the biomass as opposed to conducting one soaking and washing step. 16-. (canceled)7. A process for the soaking of lignocellulosic biomass , comprising the steps ofA) introducing a lignocellulosic biomass feedstock into a first soaking zone,B) soaking the lignocellulosic biomass feedstock in the presence of a liquid or vapor of the liquid for a first time and a first temperature correlating to a first severity of the soaking conditions creating a first liquid comprised of at least one compound selected from the group consisting of acetic acid, glucose, xylose and soluble oligomers thereof,C) separating at least a portion of the first liquid comprised of the at least one compound selected from the group consisting of acetic acid, glucose, xylose and soluble oligomers thereof from the biomass of the first soaking,D) introducing the biomass of the first soaking zone into a second soaking zone in the presence of a liquid for a second time and a second temperature correlating to a second severity of the soaking conditions creating a second liquid comprised of at least one compound selected from the group consisting of acetic acid, glucose, xylose and soluble oligomers thereof wherein the second severity is greater than first severity, andE) separating at least a portion of the second free liquid comprised of the at least one compound selected from the group consisting of acetic acid, glucose, xylose and soluble oligomers thereof from the biomass of the second soaking8. The process according to claim 7 , comprising the further steps of introducing the biomass from the second soaking zone into a third soaking zone in the presence of a liquid for a third time and at a third temperature range correlating to a third severity of the soaking conditions creating a third liquid comprised of at least one ...

CYCLODEXTRIN-BASED POLYMERS FOR THERAPEUTICS DELIVERY

The present invention relates to novel compositions of therapeutic cyclodextrin containing polymeric compounds designed as a carrier for small molecule therapeutics delivery and pharmaceutical compositions thereof. These cyclodextrin-containing polymers improve drug stability and solubility, and reduce toxicity of the small molecule therapeutic when used in vivo. Furthermore, by selecting from a variety of linker groups and targeting ligands the polymers present methods for controlled delivery of the therapeutic agents. The invention also relates to methods of treating subjects with the therapeutic compositions described herein. The invention further relates to methods for conducting pharmaceutical business comprising manufacturing, licensing, or distributing kits containing or relating to the polymeric compounds described herein. 1. A pharmaceutical composition comprising a sugar and a water soluble linear polymer conjugate , wherein the water soluble linear polymer conjugate comprises:a linear polymer comprising beta cyclodextrin moieties and comonomers which do not contain beta cyclodextrin moieties (comonomers); andcamptothecin moieties covalently linked to the linear polymer via glycine linkers, wherein the camptothecin moieties are cleaved from the water soluble linear polymer conjugate under biological conditions to release the camptothecin moieties;wherein the water soluble linear polymer conjugate comprises at least four beta cyclodextrin moieties and at least four comonomers.2. The pharmaceutical composition of claim 1 , wherein the comonomer comprises a polyethylene glycol.3. The pharmaceutical composition of claim 2 , wherein the polyethylene glycol has a molecular weight of 0.2 kDa to 5 kD.4. The pharmaceutical composition of claim 1 , wherein each of the at least four beta cyclodextrin moieties alternates with each of the at least four comonomers in the water soluble linear polymer conjugate.5. The pharmaceutical composition of claim 1 , wherein the ...

METHOD FOR SEPARATING WATER-SOLUBLE BIOLOGICAL SUBSTANCES

Provided is a novel method for separating water-soluble biological substances. A separating agent is composed by bonding a polysaccharide such as cellulose or amylose to the surface of a carrier by chemical bonding, and water-soluble biological substances are separated from a mixture of two or more types of water-soluble biological substances by chromatography using the separating agent. 1. A method for separating water-soluble biological substances from a mixture of two or more types of water-soluble biological substances by chromatography using a separating agent composed of a carrier and a polysaccharide bound to the surface of the carrier by chemical bonding.2. The method according to claim 1 , wherein the water-soluble biological substance is one or more types thereof selected from the group consisting of sugars claim 1 , nucleic acid compounds claim 1 , amino acids claim 1 , water-soluble vitamins claim 1 , acidic compounds having physiological activity and derivatives thereof claim 1 , and oligopeptides.3. The method according to claim 2 , wherein the polysaccharide is cellulose or amylose.4. A separating agent for separating water-soluble biological substances claim 2 , comprising a carrier and a polysaccharide bound to the surface of the carrier by chemical bonding.5. The separating agent according to claim 4 , wherein the water-soluble biological substance is one or more types thereof selected from the group consisting of sugars claim 4 , nucleic acid compounds claim 4 , amino acids claim 4 , water-soluble vitamins claim 4 , acidic compounds having physiological activity and derivatives thereof claim 4 , and oligopeptides.6. The separating agent according to claim 5 , wherein the polysaccharide is cellulose or amylose. The present invention relates to a method for separating water-soluble biological substances.Since biological substances having physiological activity, such as substances in the manner of sugars, nucleic acid compounds, amino acids, proteins ...