04-01-2018 дата публикации
Номер: US20180000958A1
Принадлежит:
The disclosure describes nanocarried and/or microcarried jasmonate compounds and their pharmaceutical compositions, as well as use thereof for treating or preventing angiogenesis-related or NF-κB-related disorders. Also disclosed are methods of making the nanocarried and/or microcarried compounds and their compositions. 1. A pharmaceutical composition comprising a pharmaceutically acceptable solvent and a plurality of nanocarriers or microcarriers that contain a jasmonate compound , whereinthe nanocarriers or microcarriers are formed of a cyclodextrin or a dendrimer, or are synthetic nanoemulsion particles (LDEs) comprising a cholesteryl ester core surrounded by a phospholipid layer;the nanocarriers have a size ranging from 1 nanometer (nm) to 900 nm; orthe microcarriers have a size ranging from 1 micron to 50 micron; andthe pharmaceutical composition has a concentration of the jasmonate compound ranging from 1 nM to 1 M.2. The pharmaceutical composition of claim 1 , wherein the jasmonate compound is selected from the group consisting of jasmonic acid claim 1 , 7-iso -jasmonic acid claim 1 , 9 claim 1 ,10-dihydrojasmonic acid claim 1 , 9 claim 1 ,10-dihydro-isojasmonic acid claim 1 , 2 claim 1 ,3-didehydrojasmonic acid claim 1 , 3 claim 1 ,4-didehydrojasmonic acid claim 1 , 3 claim 1 ,7-didehydrojasmonic acid claim 1 , 4 claim 1 ,5-didehydrojasmonic acid claim 1 , 4 claim 1 ,5-didehydro-7-isojasmonic acid claim 1 , cucurbic acid claim 1 , 6-epi-cucurbic acid claim 1 , 6-epi-cucurbic acid-lactone claim 1 , 12-hydroxy-jasmonic acid claim 1 , 12-hydroxy-jasmonic acid-lactone claim 1 , 11-hydroxy-jasmonic acid claim 1 , 8-hydroxy-jasmonic acid claim 1 , homo-jasmonic acid claim 1 , dihomo-jasmonic acid claim 1 , 11-hydroxy-dihomo-jasmonic acid claim 1 , 8-hydroxy-dihomo-jasmonic acid claim 1 , tuberonic acid claim 1 , tuberonic acid-O-β-glucopyranoside claim 1 , cucurbic acid-O-β-glucopyranoside claim 1 , 5 claim 1 ,6-didehydro-jasmonic acid claim 1 , 6 claim 1 ,7- ...
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