10-01-2019 дата публикации
Номер: US20190008830A1
Принадлежит:
The present invention relates to micellar nanocomplexes and a method of forming the same. The micellar nanocomplex comprises a micelle and an agent encapsulated within said micelle, where the micelle comprises a polymer-flavonoid conjugate, wherein said polymer is bonded to the B ring of said flavonoid. The micellar nanocomplex may have useful applications as a drug-delivery system. 124-. (canceled)25. A polymer-flavonoid conjugate comprising a polymer bonded to the B ring of a flavonoid.26. The polymer-flavonoid conjugate of claim 25 , wherein said polymer is selected from the group consisting of a polysaccharide claim 25 , polyacrylamide claim 25 , poly(N-isopropylacrylamide) claim 25 , poly(oxazoline) claim 25 , polyethylenimine claim 25 , poly(acrylic acid) claim 25 , polymethacrylate claim 25 , poly(ethylene glycol) claim 25 , poly(ethylene oxide) claim 25 , poly(vinyl alcohol) claim 25 , poly(vinylpyrrolidinone) claim 25 , polyethers claim 25 , poly(allylamine) claim 25 , polyanhydrides claim 25 , poly(β-amino ester) claim 25 , poly(butylene succinate) claim 25 , polycaprolactone claim 25 , polycarbonate claim 25 , polydioxanone claim 25 , poly(glycerol) claim 25 , polyglycolic acid claim 25 , poly(3-hydroxypropionic acid) claim 25 , poly(2-hydroxyethyl methacrylate) claim 25 , poly(N-(2-hydroxypropyl)methacrylamide) claim 25 , polylactic acid claim 25 , poly(lactic-co-glycolic acid) claim 25 , poly(ortho esters) claim 25 , poly(2-oxazoline) claim 25 , poly(sebacic acid) claim 25 , poly(terephthalate-co-phosphate) and copolymers thereof.27. The polymer-flavonoid conjugate of claim 25 , wherein said flavonoid is selected from the group consisting of (−)-epicatechin claim 25 , (+)-epicatechin claim 25 , (−)-catechin claim 25 , (+)-catechin claim 25 , epicatechin gallate claim 25 , epigallocatechin claim 25 , epigallocatechin gallate claim 25 , Fisetinidol claim 25 , Gallocatechin claim 25 , Gallocatechin gallate claim 25 , Mesquitol and Robinetinidol claim 25 , ...
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