Farbstoffe, brauchbar für verschiedene Anwendungen

PHOTOLEITER FUER DIE ELEKTROPHOTOGRAPHIE

CYANINFARBSTOFFE UND IHRE VERWENDUNG IN PHOTOGRAPHISCHEM DIREKTPOSITIV-AUFZEICHNUNGSMATERIAL

Spektral sensibilisiertes photographisches Material

USE OF OLIGO- OR POLYMERIC COMPOUNDS IN DYEING LIGNIN-FREE PAPER MATERIAL

Metallkomplexmethinfarbstoff

Electrophotographic materials

Photoconductive compositions as in Specification 964,873 use as photoconductive compounds pyrroles, pyrrolines, pyrrolidines, indoles, indolenines, indolines and naphthopyrrolines, including substituted derivatives and cyanine and merocyanine dyes derived from such. Many typical compounds are mentioned. The sensitizing dyestuffs, resins and auxiliary materials mentioned in Specification 964,873 may be used. Specified resins are polyvinyl formal and butyral, polyvinyl-carbazole and a terpolymer of vinyl chloride, vinyl acetate and maleic anhydride. Specifications 856,770, 883,312, 916,660 and 964,871 also are referred to.ALSO:A cyanine dye of the formula is made by reacting 3-ethyl-2-methyl-benzthiazolium iodide with N-methylisatin-a -anil. Specifications 344,409, 354,898, 428,222, 428,359, 428,360, 633,824, 856,770, 883,312, 916,660, 964,871 and 964,875 are referred to.

PHOTOGRAPHIC MATERIALS

... 1,247,553. Polymers containing imidazole groups. EASTMAN KODAK CO. 3 Oct., 1968 [9 Oct., 1967], No. 46899/68. Headings C3A and C3P. [Also in Division G2] Polymers containing imidazole units (optionally substituted) appended to the main polymer chain by means of ester or amide linkages are used as antifoggants in photographic materials (see Division G2). The following preparations of imidazole-containing polymers are illustrated: (a) Polyacrylic anhydride is reacted with 2- aminobenzimidazole to introduce amide-linked benzimidazole groups. (b) Reaction (a) is repeated but using copoly- (ethylene-maleic anhydride) instead of polyacrylic anhydride. (c) Reaction (a) is repeated using 2-amino-6- nitrobenzimidazole, 2-mercapto-6-aminobenzimidazole or 2-(#-hydroxyethyl) benzimidazole instead of the 2-aminobenzimidazole. The first two compounds give amide-linked products; the third gives an ester-linked product. (d) Polyphenyl acrylate (which may be mercapto ethanol-terminated) is reacted with ...

Polymethine dyes

Merocyanine dyes are prepared by condensing in the presence of a base a compound of the general formula with a ketomethylene compound having the grouping wherein R is phenyl or naphthyl, A is O, S, or Se, B is O or S, m is 2 or 3, X represents the non-metallic atoms necessary to complete a heterocyclic nitrogen nucleus, Q is an acid radical, and G is a reactive group. In examples, dyes are prepared by refluxing together (1) 2-methylmercaptobenzthiazole phenoxyethyl p-toluenesulphonate, 3-ethylrhodenine, triethylamine, and ethanol; (2) 2 - methylbenzthiazole phenoxyethyl p-toluenesulphonate, 3-allyl-5-acetanilidomethylenerhodanine, isopropyl alcohol, and triethylamine; (3) 2-methyl-6-methoxybenzselenazole phenoxyethyl p-toluenesulphonate, 5-(g -acetanilidoallylidene) - 3 - ethylrhodanine, isopropyl alcohol, and triethylamine; (4) 2-methylbenzthiazole phenoxyethyl p-toluenesulphonate, 5-acetanilidomethylene-3-ethyl-2-thio-2 : 4-(3 : 5)-oxazolidone ...

Polymethine dyes and process for preparing them

Complex merocyanine dyes of the general formula I wherein R represents an alkyl or hydroxyalkyl group, R1 and R2 represent substituted or unsubstituted aryl groups, R10 and R11 are alkyl groups, X is O or S, X1 is an anion and Z completes a 5-membered heterocyclic ring, are prepared by condensing a quaternary salt of the formula II wherein R8 is an alkyl group and X4 is an anion with a compound of the formula III The reaction is accelerated by heat, and basic condensing agents and inert solvents may be used. In formula I, R may be methyl, ethyl or b -hydroxyethyl, R10 and R11 may be methyl or ethyl, R1 and R2 may be phenyl, chlorophenyl, tolyl, methoxyphenyl, bromophenyl, hydroxyphenyl or naphthyl and Z may complete a naphthathiazole, benzthiazole or benzselenazole nucleus. Compounds of formula II can be prepared by quaternarizing the corresponding bases with a salt R10X4, and the bases can be prepared by condensing ...

Improvements in or relating to photographic sensitising dyestuffs

... 544,645. Cyanine dyes ; photographic sensitisers. KENDALL, J. D., and FRY, D. J. Oct. 16, 1940, No. 15357. Sample furnished. [Class 2 (iii)] [Also in Group XX] Cyanine dyestuffs are prepared by condensing an alkyl or aralkyl quaternary salt of a compound having the formula : wherein R 1 is an alkyl or aralkyl group, R 2 is hydrogen or an alkyl, aralkyl or aryl group, R is hydrogen or an alkyl, aralkyl, aryl or heterocyclic group, R 4 is hydrogen or an alkyl group, A is oxygen or an NR 5 group (R 5 being an alkyl, aryl, aralkyl or heterocyclic group), D is the residue of a heterocyclic nucleus, n is 0 or 1 and x is 0, 1, 2 or 3, with the quaternary salt of a heterocyclic nitrogen compound containing an or re-active thioether, selenoether or a (CH =CH)mNH 2 group wherein a hydrogen atom of the NH 2 group may be substituted by an acyl, aryl, or acylaryl group and m is 1, 2 or 3. The quaternary salts having the above general formula may be prepared by the processes described in Specifications ...

Improvements in and relating to polymethine dye intermediates and to the production of polymethine dyes

... 556,266. Polymethine dyes and intermediates. KODAK, Ltd. Sept. 26, 1941, No. 12486. Convention date, Oct. 18, 1940. Samples furnished. [Class 2 (iii)] [Also in Group XX] A compound of the general formula of Fig. 1 where R represents an alkyl or aryl radical, R1 represents an alkyl radical, X represents an acid radical, and Z the non-metallic atoms necessary to complete a 5- or 6- membered heterocyclic nucleus is prepared by condensing a #-alkoxyacrolein acetal with a cyclammonium quaternary salt containing a methyl group in the -position to the nitrogen atom and employing as the reaction medium substantially anhydrous acetic acid not containing more than 1 per cent. of water. From 1 ¢ to 3 molecular proportions of acrolein acetal may be used for each molecular proportion of cyclammonium quaternary salt. The cyclammonium quaternary salt may be a quinoline, benzoxazole, naphthoxazole, benzthiazole, naphthathiazole, benzselenazole, or thiazoline derivative. The reaction medium may ...

Pyrylium Compounds

... 1,150,614. Tetrahydrobenzopyrilium and -thiapyrilium compounds. EASTMAN KODAK CO. 27 Sept., 1966 [27 Sept., 1965], No. 43187/66. Heading C2C. [Also in Divisions C4, G2 and H1] Tetrahydrobenzopyrylium salts of the general formula wherein Q is oxygen, S indicates a saturated ring, #X is the perchlorate ion, R, R1 and R 2 are hydrogen, R 3 and R 4 are each phenyl and R 1 is hydrogen, tert-butyl, cyclohexyl, methyl or ethyl, are made by reacting chalcone and perchloric acid with acetic anhydride and then reacting the mixture with, respectively, cyclohexanone, 4-tert-butylcyclohexanone, 4-cyclohexylcyclohexanone, 4 - methylcyclohexanone and 4-ethylcyclohexanone. The compound of the above formula where Q, S, X, R, R1 and R 2 have . the values above, R 1 is hydrogen and R 3 and R 4 are each 4-amyloxyphenyl is made by the above reaction using 4: 41-bis-(amyloxy) chalcone and cyclohexanone. The tetrahydrobenzothiapyrylium salt of the above formula where S, X, R, R1 ...

Photographic Emulsions

... 1,186,720. Cyanine dyes. EASTMAN KODAK CO. 5 May, 1967 [11 Aug., 1966; 17 Jan., 1967], No. 20914/67. Heading C4P. [Also in Division G2] Cyanine dyes have the formula wherein R is alkyl, substituted alkyl, aryl, acyl or an organic sulphonyl radical; R 1 is alkyl or substituted alkyl ; R 2 and R 3 are each H, alkyl, aryl, carboxyl, sulpho, -NO 2 , -CN, or halogen; X is an anion; Z represents the non- metallic atoms to complete a heterocyclic nucleus; n is 0 or 1. Z may represent the atoms for completing a thiazole, oxazole, selenazole, thiazoline, pyridine, quinoline or imidazole nucleus. The dyes may be prepared by condensing the carbazole-3-carboxaldehyde with a methyl substituted quaternary N-containing heterocyclic compound in a dehydrating medium, e.g. (CH 3 CO) 2 0, at an elevated temp., e.g. under reflux.

CYANINE DYE SALTS AND MEROCYANINE DYES, AND THEIR USE IN SILVER HALIDE PHOTOGRAPHIC EMULSIONS

... 1300641 Pyrido-benzimidazoles MINNESOTA MIN3G & MFG CO 20 Jan 1970 [22 Jan 1969] 2775/70 Heading C2C [Also in Divisions C4 and G2] 5-Aminobenzimidazoles are reacted with methyl vinyl ketone to give a compound of formula (in which R and R 1 are each H or optionally substituted alkyl) which is then converted to a quaternary salt. In an example, a compound in which R11 is CH 3 and R 1 is C 2 H 5 is prepared by heating 5 - amino - 1 - ethyl - 2 - methylbenz. imidazole, methyl vinyl ketone, FeCl 3 .6H 2 O and ZnCl 2 in ethanol and treating with NaOH; the compound is then quaternized with C 2 H 5 I.

Aminothiete dioxides and processes for preparing them

A dye of the formula is prepared by reacting together compounds of the formulae at pH 8-9.ALSO:The invention comprises compounds of the formula where each R1 is alkyl of 1-8 carbon atoms, or the R1 groups together with the nitrogen atom form a morpholine, thiomorpholine, pyrrolidine or piperidine ring which may be substituted by alkyl groups having 1-4 carbon atoms, and R2, R3 and R4 are H or hydrocarbon groups free from ethylenic or acetylenic unsaturation containing 1-8 carbon atoms, or R3 and R4 may form a cyclopentyl or cyclohexyl group with the carbon atom to which they are attached. The compounds may be prepared by reacting a sulphonyl halide of the formula where X is Cl or Br, in the presence of a hydrogen halide acceptor, with either a ketene O,N-acetal or a ketene aminal of the formulae where R5 is alkyl of 1-8 carbon atoms. Preferred hydrogen halide acceptors ...

ENERGY-SENSITIVE COMPOSITIONS AND MATERIALS

... 1276129 Light- and heat-sensitive materials EASTMAN KODAK CO 9 Oct 1969 [9 Oct 1968] 49612/69 Heading G2C [Also in Division D2] A light- or heat-bleachout composition comprises a polymeric binder and a dye containing an unsaturated heterocyclic ring containing a nitrogen atom, which may bear a positive charge, and attached to the nitrogen atom a group -O-R1 wherein R1 is acyl or hydrocarbon which may be substituted. These compositions may be used as antihalation or filter layers in silver halide emulsions. The dyes are preferably pyridocarbo- or thia-cyanines. If a mixture of magenta, yellow and cyan dyes are used, a positive coloured image is produced on exposure. When used as antihalation or filter layers, the residual dye is bleached by exposure during processing.

Improvements in or relating to methine dyes

... 1 ;1 ;2-Trimethyl-3 ;4-diazaindene is prepared by refluxing 2-hydrazino pyridine and methyl isopropyl ketone in benzene and removing the water formed by azeotropic distillation. The residue is heated with anhydrous zinc chloride, whereupon ammonia is evolved to yield the required product. The product is quaternized at the 4-N atom by refluxing it in acetone with methyl iodide. Reference also is made to the ethyl iodide and to 1 : 1-diethyl-2-methyl-3 ;4-diazaindene and its methyl toluene-b -sulphonate; to 1 ;1 ;2 ;5-tetramethyl-3 ;4-diazaindene-4-methiodide and to 1 ;1 ;2 ;7-tetramethyl-3 ;4-diazaindene-4-methiodide.ALSO:Methine dyes having one of the general formulae I, II or III:- wherein R1, R2, R5 and R6 are alkyl groups of 1 to 4 carbon atoms, R3 is an alkyl or hydroxyalkyl group of 1 to 4 carbon atoms or an aralkyl group, R4 is an alkyl group of 1 to 4 carbon atoms or an aralkyl group, m and n are 0 or 1, X is an anion, Y is H or an alkyl group of 1 to 4 carbon ...

CYANINE DYES AND THEIR USE AS SPECTRAL SENSITIZERS IN DIRECT POSITIVE PHOTOGRAPHIC MATERIALS

Novel direct-positive photosensitive silver halide emulsions contain a sensitising quantity of at least one cyanine dye derived from 5- or 6-membered heterocyclic nuclei, wherein the said nuclei are linked by a methine chain, at least one of the said heterocyclic nuclei being a nucleus from the benzoxazole series or benzothiazole series, having at least two halogen atoms as substituents on the benzene ring. These emulsions are used in photographic elements which contain at least one layer of these novel emulsions. The cyanine dyes are used as spectral sensitizers in direct-positive photographic materials.

QUATERNISED MEROCYANINE DYES AND THEIR USE FOR SPECTRALLY SENSITISING DIRECT POSITIVE SILVER HALIDE EMULSIONS

Improvements in or relating to merocyanine dyes

... 3 - Benzoyl - 1 - methyl - 2 - thiohydantoin is prepared by heating equimolecular amounts of benzoyl isothiocyanate and sarcosine on a waterbath.ALSO:Merocyanine dyes of the general formula wherein R1 and R2 are alkyl, aralkyl or aryl groups, R3 is a phenyl group, Z is = N or = CH-, n is 0 or 1, m is 0, 1 or 2 and D completes a 5- or 6-membered heterocyclic nucleus, are described. They may be prepared by reacting a quaternary cyclammonium salt having a reactive thioether or acetanilidovinyl group with a compound of the formula In the examples, D completes a benzthiazole, benzoxazole, thiazoline, pyrroline, quinoline, quinazoline or indolenine nucleus. In Example 16, 3-benzoyl-1-methyl-2-thiohydantoin is first reacted with b -anilino-acrolein anil hydrochloride in the presence of acetic anhydride and sodium acetate, and the product is reacted with 2-methylbenzthiazole methiodide to give a dye wherein m is 2. According to the Provisional Specification ...

DYES HAVING A PYRIMIDINE NUCLEUS AND PHOTOGRAPHIC MATERIALS CONTAINING THE DYES

PHOTOGRAPHIC SILVER HALIDE EMULSIONS

... 1281566 Cyanine dyes EASTMAN KODAK CO 9 Oct 1969 [9 Oct 1968] 49610/69 Heading C4P [Also in Division G2] Cyanine dyes for modifying the sensitivity of silver halide emulsions contain a 2-arylindole nucleus which is substituted in the 1-position by an alkoxy, substituted alkoxy or cycloalkoxy radical and joined at the 3 position to a methine linkage bonded to a desensitizing nitrogencontaining heterocyclic nucleus containing 5 or 6 atoms in the heterocyclic ring containing the said nitrogen atom. Preferably the dye is of one of the formulµ (in which E is optionally substituted aryl; R is cycloalkyl or optionally substituted alkyl; D and R 2 are each H, alkyl or optionally substituted aryl; R 3 is cycloalkyl, alkenyl, alkoxy, or optionally substituted aryl or alkyl; is an optionally substituted methine linkage; X is an anion; Q 1 and Q 2 each complete a desensitizing nucleus; n is 0-3; m is 1-3; g is 0 or 1). Specified dyes are those in which E is phenyl, R is CH 3 or C 2 H 5 , R 2 is H, ...

HEAT SENSITIVE PICTURE RECORDING ELEMENT

FLUORESCENT MARKING COMPLEXES WITH LARGE STOKES SHIFT THE BY CONNECTION ARE ARRANGED BY CYANINEN AND OTHER RESONANCE ENERGY-TRANSMISSION-ABLE FLUOROCHROMEN

Process for the preparation of alpha- and beta-cryptoxanthin

LACTAM-BASED PIGMENTS AND THE USE THEREOF IN THE PRODUCTION OF COLOURED PLASTICS OR POLYMERIC COLOUR PARTICLES

CHROMOGENIC MEROCYANINE ENZYME SUBSTRATES

PHOTOSENSITIVE COMPOSITIONS

CYANINE DYES CONTAINING AN IMIDAZO-(4,5-B)-QUINOXALINE NUCLEUS THEIR USE IN PHOTOGRAPHIC ELEMENTS

SELENIUM-CONTAINING MEROCYANINE DYES

NOVEL SELENIUM-CONTAINING MEROCYANINE DYES A merocyanine dye having the formula: wherein: R1 and R2 independently are H, alkyl of 1-10 carbon atoms, alkoxy of 1-3 carbon atoms or phenyl or substituted phenyl, and any of R1 and R2, R1 and R7, and R2 and R8 can together comprise the atoms necessary to form a fused aromatic ring on the benzene radical to which they are attached; R5 and R6 comprise alkyl of from 1-18 carbon atoms provided that the sum of the carbon atoms in R5 and R6 is at least 8, or benzyl; R7 and R8 are H, or any pair of R7 and R1, R1 and R2 or R2 and R7 can comprise the atoms necessary to form together with the atoms on the benzene radical to which they are attached, a fused aromatic ring; R9 is an alkylene of 2-9 carbon atoms which can be interrupted by CONH; and Z+ is a cation selected from Na+, 1/2Ba2+ (C2H5)3NH+, K+, NH4+ and Li+. This dye is useful in a method for inactivating viruses comprising contacting the viruses with the compound and exposing the resulting ...

CYANINE DYE SALTS,MEROCYANINE DYES,AND THEIER USE IN HALIDE PHOTOGRAPHIC EMULSIONS

Emulsion photographique sensible et procédé pour sa préparation.

Verfahren zur Herstellung von N-Aminoalkyl-3-chlor-phenothiazinen bzw. deren Hydrochloriden

Verfahren zur Sensibilisierung von photographischen Halogensilberemulsionen

Verfahren zur Sensibilisierung von Halogensilberemulsionen.

Verfahren zur Herstellung von Sensibilisierungsfarbstoffen

Verfahren zur Herstellung von Cyaninfarbstoffen

Verfahren zur Herstellung von haltbaren Druckpasten für das Bedrucken von Gebilden aus Polyacrylnitril, acrylnitrilhaltigen Mischpolymerisaten und Acetatreyon

Flächenförmiges gefärbtes Material

Matériel photographique

Spektral sensibilisiertes lichtempfindliches Material

Emulsione fotografica e loro utilizzazione

Verfahren zur Herstellung von Cyaninfarbstoffen

Photographische Halogensilberemulsion

Procédé pour sensibiliser une composition photosensible

Optisch sensibilisiertes lichtempfindliches Material

Emulsion photographique

Procédé pour sensibiliser spectralement une émulsion photographique

Verfahren zur Sensibilisierung von Halogensilberemulsionen

Verfahren zur Herstellung von Sensibilisierungsfarbstoffen

Verfahren zur Herstellung von Sensibilisierungsfarbstoffen

Verfahren zur Sensibilisierung von Halogensilberemulsionen

Spektral sensibilisiertes lichtempfindliches photographisches Material

Composition polymère photoréticulable

Matériel sensible à l'énergie radiante

Photographische Direktumkehr-Emulsion

Emulsion photographique

PROCEDURE FOR THE FAERBEN OF LINEAR POLYESTERS IN THE MASS.

Direct-positive photosensitive emulsions and use of emulsions

Use of cyanine dyes in photographic direct positive recording material

Infrared absorbing dye

Manufactoring process of aldehydes of polyméthines unsaturated

CYANINE DYES AND THEIR USE IN PHOTOGRAPHY

New photoconductive composition

Process for the preparation of dyes containing méthine

Process for the preparation of new dyes optical sensitizers and for the sensitizing of photographic emulsions by means of these dyes

Dyes sensitizers belonging to the series of cyanins, mérocyanines or rhodacyanines, or with the styrylic series and their preparation

Method of preparation of intermediaries of dyes and dyes sensitizers for the photographic emulsions

New 2 (omega-substituted vinylene) - 3,3-disubstituted 3eta-indols and their process of production

Linear polyester resins prodn

News mérocyanines, proceeded of preparation and applications

CYANINE DYE SALTS AND MEROCYANINE DYES, AND THEIR USE IN SILVER HALIDE PHOTOGRAPHIC EMULSIONS

Recovering solar energy by photochemical isomerisation - of a trans isomer to the cis form, then converting it back exothermically

New process of spectral sensitizing and solution used in this process

LONG WAVELENGTH THIOL-REACTIVE FLUOROPHORES

Reactive fluorescent dyes compositions and methods of using same are disclosed. Squaraine nucleus, Nile Red nucleus, benzodioxazole nucleus, coumarin nucleus or aza coumarin nucleus dyes are disclosed having thiol-reactive groups. Squaraine nucleus, Nile Red nucleus, benzodioxazole nucleus, coumarin nucleus or aza coumarin nucleus dyes are disclosed that exhibit a fluorescence emission of at least about 575 nm. Biosensors are disclosed having a binding protein and a squaraine nucleus, Nile Red nucleus, benzodioxazole nucleus, coumarin nucleus or aza coumarin nucleus.

2(5H)-FURANO DYES AS SENSITIZERS FOR ORGANIC PHOTOCONDUCTORS

Fluorescent labeling complexes with large Stokes shift formed by coupling together cyanine and other fluorochromes capable of resonance energy transfer

The present invention provides low molecular weight fluorescent labeling complexes with large wavelength shifts between absorption of one dye in the complex and emission from another dye in the complex. These complexes can be used, for example, for multiparameter fluorescence cell analysis using a single excitation wavelength. The low molecular weight of the complex permits materials labeled with the complex to penetrate cell structures for use as probes. The labeling complexes are synthesized by covalently attaching through linkers at least one cyanine fluorochrome to another low molecular weight fluorochrome to form energy donor-acceptor complexes. Resonance energy transfer from an excited donor to fluorescent acceptor provides wavelength shifts up to 300 nm. The fluorescent labeling complexes preferably contain reactive groups for the labeling of functional groups on target compounds, such as derivatized oxy and deoxy polynucleic acids, antibodies, enzymes, proteins and other materials ...

Merocyanine dye

Dyes for labelling molecular ligands

Cyanine dyes with improved fluorescence intensity and photostability.

Process for preparing nu-arylthiazolinium quaternary salts

Long wavelength thiol-reactive fluorophores

Reactive fluorescent dyes compositions and methods of using same are disclosed. Coumarin nucleus or aza coumarin nucleus dyes are disclosed having thiol-reactive groups. Coumarin nucleus or aza coumarin nucleus dyes are disclosed that exhibit a fluorescence emission of at least about 575 nm. Biosensors are disclosed having a binding protein and a Coumarin nucleus or aza coumarin nucleus.

Светочувствительное покрытие

ELEKTROPHOTOGRAPHISCHES AUFZEICHNUNGSMATERIAL

Photographische Silberhalogenidemulsion

Photographische Direktumkehr-Emulsionen

LICHTEMPFINDLICHES PHOTOGRAPHISCHES AUFZEICHNUNGSMATERIAL

Verfahren zum Sensibilisieren von Halogensilberemulsionen

Methinverbindung.

New cyanine and related dyes

Carbocyanine, rhodacyanine, monomethinecyanine and merocyanine dyes are derived by known methods from the quaternary salts of a base of the formula wherein R1 is hydrogen, phenyl or alkyl of 1-6 C atoms and A is hydrogen, halogen or alkyl or alkoxy of 1 to 6 C atoms. In the examples, symmetrical carbocyanine dyes are prepared by reacting the quaternary salts with ethyl orthoformate, unsymmetrical dyes are prepared by reacting the quaternary salts with 2-methylmercaptoquinolinium ethosulphate or 2-acetanilidovinylbenzthiazolium ethiodide, a merocyanine dye is derived from 3-ethyl-5-acetanilido-methylene rhodanine, and complex rhodacyanine dyes are obtained by reacting the quaternary salts with a quaternary salt of the merocyanine prepared above or with a quaternary salt derived from 3-ethyl-5[a -phenyl - b (3 - ethyl - a - naphthothiazolinylidene-2)] rhodanine.

Cyanine dyes

The invention provides a novel class of cyanine dyes that are functionalized with sulfonic acid groups and a linker moiety that facilitates their conjugation to other species and substituent groups which increase the water-solubility, and optimize the optical properties of the dyes. Also provided are conjugates of the dyes, methods of using the dyes and their conjugates and kits including the dyes and their conjugates.

Phospholinked dye analogs with an amino acid linker

In various embodiments, the present invention provides fluorescent dyes that are linked to another species through an amino acid or peptide linker. In an exemplary embodiment, the dye is linked to a polyphosphate nucleic acid through an amino acid or peptide linker. These conjugates find use in single molecule DNA sequencing and other applications. In various embodiments, the dye moiety is a cyanine dye. Cyanine dyes that are highly charged, such as those including muliple sulfonate, alkylsulfonate, carboxylate and/or alkylcarboxylate moieties are examples of cyanine dyes of use in the compounds of the invention.

Dye and coloring photosensitive composition

The present invention provides a dye that is excellent in solubility and excellent in heat resistance and a novel compound that is preferable for the dye, and specifically provides a yellow dye having a wavelength of maximum absorption in the region of 400 to 450 nm, and also provides a coloring (alkali-developable) photosensitive composition using the above-mentioned dye, and an optical filter using the above-mentioned coloring (alkali-developable) photosensitive composition, specifically a color filter that does not decrease luminance and thus is preferable for image display devices such as liquid crystal display panels. Specifically, a compound represented by the following general formula (1) is used as the dye. The content of the above-mentioned general formula (1) is as described in the description.

Trimethine cyanine and its use

The present invention relates to a trimethine cyanine represented by the formula (1): wherein all symbols are defined as in the specification.

FLUORESCENT POLYMETHINE CYANINE DYES

The invention encompasses fluorescent cyanine dyes and methods of using such dyes. In particular, the invention encompasses near infrared polymethine cyanine dyes. 1. A fluorescent cyanine dye , the dye having two nitrogen atoms that are each independently a part of at least two different heteroaromatic rings , the heteroaromatic rings being joined by a polymethine chain , the polymethine chain comprising a carbocylic ring that is centrally located within the polymethine chain , the carbocylic ring being derivatized with a hydrocarbyl or a substituted hydrocarbyl group at the meso position in a manner such that the dye is substantially fluorescent.2. The fluorescent cyanine dye of claim 1 , wherein the absorption maxima is at least 600 nm.6. A compound claim 1 , the compound comprising the fluorescent cyanine dye of conjugated to a biomolecule.7. The compound of claim 6 , wherein the biomolecule is selected from the group consisting of an antigen claim 6 , an antibody claim 6 , a drug claim 6 , a vitamin claim 6 , and a small molecule.8. The compound of claim 6 , wherein the biomolecule is selected from the group consisting of a peptide claim 6 , a nucleic acid claim 6 , a carbohydrate claim 6 , and a lipid.9. The compound of claim 8 , wherein the biomolecule is a peptide. This application is a divisional application of U.S. Ser. No. 12/192,480, filed on Aug. 15, 2008, which claims the benefit of U.S. provisional application No. 60/955,908, filed Aug. 15, 2007, hereby incorporated by reference in its entirety.The present invention was supported by the National Institute of Health Grant Nos. R01 EB 1430 and R01 CA 109754. The United States Government has certain rights in this invention.The invention encompasses stable near-infrared cyanine dyes and methods of using such dyes.Molecules that absorb and emit light in the near-infrared (NIR) wavelengths have become the central focus of numerous analytical, biological, and spectroscopic studies because their spectral, ...

Photopolymer formulation for producing holographic media having highly crosslinked matrix polymers

The invention relates to a photopolymer formulation comprising a polyol component, a polyisocyanate component, a writing monomer, and a photoinitiator, containing a coinitiator and a dye having the formula F An, where F stands for a cationic dye and An″ stands for an anion, wherein the dye having the formula F An comprises a water absorption of =5%. The invention further relates to a holographic medium, in particular in the form of a film, containing a photopolymer formulation according to the invention, to the use of such a medium for recording holograms, and to a special dye that can be used in the photopolymer formulation according to the invention.

Novel compound, dye and colored photosensitive composition

Disclosed are a dye that is excellent in solubility and heat-resistance, and a novel compound that is suitable for the dye, and specifically provides a yellow dye having a maximum absorption wavelength in the region of 420 to 470 nm. Also disclosed are a colored (alkali-developable) photosensitive composition and an optical filter using the dye, and specifically provides a color filter that does not decrease luminance and thus is preferable for an image display device such as a liquid crystal display panel. Specifically, disclosed are a novel compound represented by the following general formula (1), a dye using the compound, and a colored (alkali-developable) photosensitive composition and a color filter. The content of the above-mentioned general formula (1) is as described in the description.

Photoelectric conversion device, photoelectric conversion device material, photosensor and imaging device

A photoelectric conversion device comprising an electrically conductive film, an organic photoelectric conversion film, and a transparent electrically conductive film, wherein the organic photoelectric conversion film contains a compound represented by the following formula (1) and an n-type organic semiconductor: wherein each of R 1 and R 2 independently represents a substituted aryl group, an unsubstituted aryl group, a substituted heteroaryl group or an unsubstituted heteroaryl group, each of R 3 to R 11 independently represents a hydrogen atom or a substituent provided that an acidic group is excluded, m represents 0 or 1, n represents an integer of 0 or more, R 1 and R 2 , R 3 and R 4 , R 3 and R 5 , R 5 and R 6 , R 6 and R 8 , R 7 and R 8 , R 7 and R 9 , or R 10 and R 11 may be combined each other to form a ring, and when n is an integer of 2 or more, out of a plurality of R 7 's and R 8 's, a pair of R 7 's, a pair of R 8 's, or a pair of R 7 and R 8 may be combined each other to form a ring.

Fluorinated voltage sensitive dyes, preparation thereof, and optical methods of use

A fluorinated voltage sensitive dye has the structure wherein p is 0, 1, or 2; X q− is an anionic counterion having a charge, q, that is 1 or 2; n is 1 or 2; R 1 is an optionally substituted C 1 -C 12 , alkyl; R 2 is hydrogen, and R 3 is hydrogen or fluorine; or R 2 and R 3 collectively form a divalent —CH═CH—CH═CH— group; R 4 and each occurrence of R 5 are each independently hydrogen or fluorine; R 6 is hydrogen or fluorine or trifluoromethyl; and each occurrence of R 7 is independently C 1 -C 6 alkyl; provided that the dye comprises at least one fluorine atom. The dye is particularly useful for monitoring the dynamics of action potentials in axons and/or dendrites.

NOVEL COMPOUND HAVING alpha-CYANOACRYLATE STRUCTURE, DYE, AND COLORED PHOTOSENSITIVE COMPOSITION

A compound represented by the following general formula (1). In the formula, A represents a benzene ring, a naphthalene ring and the like, wherein these rings may be substituted with a halogen atom and the like, R 1 represents a hydrogen atom and the like, R 2 represents a C 1-35 hydrocarbon group having or not having at least one group selected from an epoxy group, 4-vinylphenyl group and a (meth)acryloyloxy group, or a hydrogen atom, wherein at least one of R 2 with n occurrences is a C 3-35 hydrocarbon group having at least one group selected from an epoxy group, a 4-vinylphenyl group and a (meth)acryloyloxy group, n represents an integer of 1 to 6, and X represents a nitrogen atom, an oxygen atom, a sulfur atom, a phosphorus atom, or an n-valent organic group having 35 or less carbon atoms.

Near-ir glucose sensors

Glucose-sensing luminescent dyes, polymers, and sensors are provided. Additionally, systems including the sensors and methods of using these sensors and systems are provided.

Electrowetting element

Electrowetting element including a compound comprising a plurality of colorant moieties and a linker. The plurality of colorant moieties includes a first colorant moiety having a first net dipole and a second colorant moiety having a second net dipole. The plurality of colorant moieties are linked by and disposed around the linker so that the first net dipole and the second net dipole at least partially cancel each other.

Dyes for analysis of protein aggregation

Provided are dyes and compositions which are useful in a number of applications, such as the detection and monitoring protein aggregation, kinetic studies of protein aggregation, neurofibrillary plaques analysis, evaluation of protein formulation stability, and analysis of molecular chaperone activity.

MODIFIED BIOTIN, STREPTAVIDIN MUTANT, AND USAGE OF THEM

An object of this invention is to provide a streptavidin mutant reduced in affinity to the naturally-occurring biotin, and to provide a modified biotin which shows a high affinity to such streptavidin mutant reduced in affinity to the naturally-occurring biotin. This invention can provide a compound composed of a dimer of modified biotin, a streptavidin mutant, angsd usage of them. 1. A streptavidin mutant comprising an amino acid sequence in which Asn at amino acid residue 37 in the amino acid sequence represented by SEQ ID NO: 3 is substituted with other amino acid residue.2. A streptavidin mutant comprising an amino acid sequence represented by SEQ ID NO: 4.3. A DNA encoding the streptavidin mutant described in .4. A streptavidin mutant-molecular probe conjugate claim 1 , obtained by combining the streptavidin mutant described in with a molecular probe.5. The streptavidin mutant-molecular probe conjugate of claim 4 , wherein the molecular probe is an anti-human CD20 antibody.6. The streptavidin mutant-molecular probe conjugate of claim 4 , wherein the molecular probe is rituximab.7. The streptavidin mutant-molecular probe conjugate of claim 4 , wherein the molecular probe is an anti-epiregulin single chain antibody.8. A therapeutic agent claim 4 , or in vivo or in vitro diagnostic agent claim 4 , comprising the streptavidin mutant-molecular probe conjugate described in . The present application is a Divisional of U.S. application Ser. No. 15/119,441, filed Aug. 17, 2016, which is a National stage of International Patent Application No. PCT/JP2015/054431, filed Feb. 18, 2015, which claims priority to Japanese Application No. 2014-212861, filed Oct. 17, 2014 and Japanese Application No. 2014-028525, filed Feb. 18, 2014, the contents of which are expressly incorporated by reference herein in their entireties.This invention relates to compound composed of a dimer of modified biotin, a streptavidin mutant, and usage of them.Avidin and biotin, or, streptavidin and ...

IMAGE DEVICE AND IMAGING APPARATUS

An imaging device, comprising: an infrared light absorption layer including a cyanine dye represented by Chemical Formula (A) below: wherein Rand Rare selected from the group consisting of: a chain alkyl group,a cyclic alkyl group, a phenyl group, and a benzyl group; wherein the chain alkyl group and the cyclic alkyl group including at least one group member selected from the group consisting of: 1) a first group having one or more hydrogen atoms in a first alkyl group substituted with at least one functional group selected from the group consisting of: a halogen atom, an alkoxy group, an alkanoloxy group, an amino group, a thiol group, and a mercapto group; 2) a second group having at least one reactive group selected from the group consisting of: a vinyl group, an acrylic group, a carbonyl group, a carboxyl group, an alkenyl group, an alkenyloxy group, an alkoxycarbonyl group, a nitrile group, a carboxyl group, a carbonyl group, a sulfonyl group, a sulfamoyl group, a carbamoyl group, a benzoyloxy group, and a cyano group,wherein the reactive group is any one of introduced at a terminal alkyl group of at least one of the chain alkyl group and the cyclic alkyl group and positioned two or more carbon atoms away from an indoline ring; 3)an unsubstituted chain alkyl group; and 4) an unsubstituted cyclic alkyl group; and wherein X represents an anion. 2. The imaging device according to claim 1 , wherein at least one of Rand Rare selected from the group consisting of 1) a linear alkyl group having 1 to 16 carbon atoms claim 1 , 2) a group having a siloxane claim 1 , alkoxysilane claim 1 , acrylic or epoxy structure introduced to the terminal alkyl group of the chain alkyl group claim 1 , 3) a polyether group claim 1 , 4) the benzyl group claim 1 , and 5) the phenyl group.3. The imaging device according to claim 1 , wherein the cyanine dye includes an absorption maximum wavelength at 600 nm to 1200 nm and has a ratio of a molar extinction coefficient in the absorption ...

Novel ir dyes and laser markable articles comprising such ir dyes

Infrared dyes having an infrared absorption maximum above 1130 nm with minor colouration in the visual spectrum. The infrared dyes are especially useful for producing multicolour laser marked security documents having reduced background coloration and enhanced colour gamut.

Delocalized Lipophilic Cation Compounds and Methods of Use Thereof

Provided are delocalized lipophilic cation (DLC) compounds and methods of using such compounds. Also provided are pharmaceutical compositions that include a DLC compound. Provided methods include methods of killing cells and methods of fluorescently labeling mitochondria by contacting the cells with a DLC compound of the present disclosure. Also provided are methods of imaging cell mitochondria, methods of determining whether a patient has a mitochondria related disease, and methods of treating a patient for a mitochondria related disease. Kits that include compounds of the present disclosure are also provided.

METHODS AND COMPOSITIONS FOR USING SOLVATOCHROMIC DYES TO DETECT THE PRESENCE OF HOMEOPATHIC POTENCIES

A method is provided for obtaining a characteristic of a homeopathic preparation, particularly its potency. In particular aspects, solvatochromic dyes may be used for detection of a homeopathic preparation. 1. A method of quantifying a homeopathic potency effect , comprising the steps of:a) obtaining a sample solution by adding a homeopathic potency solution to a dye solution comprising a polar and polarizable molecule in a solvent;b) obtaining a reference solution comprising an equivalent amount of the dye solution of step a);c) obtaining a spectrum of the sample solution;d) obtaining a spectrum of the reference solution;e) obtaining a difference spectrum, wherein the difference spectrum is the difference between the sample solution spectrum and the reference solution spectrum; andf) quantifying the potency effect of the homeopathic potency solution by identifying a maximum value of the difference spectrum.2. The method of claim 1 , wherein the homeopathic potency solution has been prepared by a serial dilution of between 100to 100.3. The method of claim 2 , wherein the homeopathic potency solution has been prepared by a serial dilution of more than 100.4. The method of claim 2 , wherein the homeopathic potency solution has been prepared by a serial dilution of up to 100.5. The method of any of - claim 2 , wherein the polar and polarizabale molecule is a negatively solvatochromic dye.6. The method of any of - claim 2 , wherein the polar and polarizabale molecule is a positively solvatochromic dye.7. The method of claim 5 , wherein the negatively solvatochromic dye is ET33 claim 5 , ET30 claim 5 , or BM.8. The method of claim 6 , wherein the positively solvatochromic dye is BDN claim 6 , BDF claim 6 , NR claim 6 , or PB.9. The method of any of - claim 6 , wherein the polar and polarizable molecule is a halochromic dye.101. The method of . claim 8 , wherein the halochromic dye is 6-amino-2-naphthoic acid (6-ANA) or 6-amino-2-anthracenic acid (6-AAA).11. The method of ...

METHODS FOR DYE SELECTION FOR PROTEIN MELT TEMPERATURE DETERMINATIONS

According to the present teachings, compositions, kits, and methods for protein melt analysis are provided that utilizing one or more fluorophore dyes. In some embodiments, a method comprises preparing a sample by mixing at least one protein with two or more dyes, and applying a controlled heating, while recording the fluorescence emission of the sample. The methods can be used, for example, for screening conditions for optimized protein stability, screening for ligands that bind and enhance protein stability (e.g., protein-protein interactions), screening for mutations for enhanced stability, screening crystallization conditions for protein stability, screening storage conditions for protein stability, and screening conditions in which a protein will be used (e.g., production conditions, treatment conditions, etc.) for protein stability. 118.-. (canceled)19. A composition comprising at least one protein , and a mixture of at least two fluorophore dyes , wherein each of the at least two fluorophore dyes is configured to provide at least a minimally fluorescent signal when the at least one protein is present in its native state and when the at least one protein is present in an unfolded state , then each of the at least two fluorophore dyes is configured to provide a substantially increased fluorescent signal.20. The composition of claim 19 , wherein one of the at least two fluorophore dyes is Nile Red.21. The composition of claim 19 , wherein one of the at least two fluorophore dyes is a styryl dye.23. The composition of claim 19 , wherein the at least one protein comprises a protein/ligand complex.24. The composition of claim 23 , wherein the protein/ligand complex is an antibody/antigen complex.25. The composition of claim 23 , wherein the ligand is a peptide claim 23 , a polynucleotide claim 23 , or an aptamer26. A kit comprising a composition comprising at least two fluorophore dyes claim 23 , wherein each of the at least two fluorophore dyes is configured to ...

Compound for organic photoelectric device and organic photoelectric device image sensor, and electronic device including the same

A compound for an organic photoelectric device includes at least one of a compound represented by Chemical Formula 1, a compound represented by Chemical Formula 2 and a combination thereof.

Optical filter and imaging device

An optical filter includes an absorption layer containing a near-infrared absorbing dye with an absorption characteristic in dichloromethane satisfying (i-1) to (i-3). (i-1) In an absorption spectrum of a wavelength of 400 to 800 nm, there is a maximum absorption wavelength λ max in 670 to 730 nm. (i-2) Between a maximum absorption coefficient ∈ A of light with a wavelength of 430 to 550 nm and a maximum absorption coefficient ∈ B of light with a wavelength of 670 to 730 nm, the following relational expression: ∈ B /∈ A ≧65 is established. (i-3) In a spectral transmittance curve, the difference between a wavelength λ 80 with which the transmittance becomes 80% on a shorter wavelength side than the maximum absorption wavelength with the transmittance at the maximum absorption wavelength λ max set to 10% and the maximum absorption wavelength λ max is 65 nm or less.

AZACYANINE DYES AND USE THEREOF

The application provides fluorescent dyes, which are cyanine dyes that incorporate additional aza moieties in the indolenium heterocycles and/or in the methine chains connecting them. Symmetrical and unsymmetrical chemically reactive azacyanine dyes are described for conjugation, as well as their bioconjugates for in-vitro and in-vivo assays and fluorescence imaging. 115-. (canceled)20. The dye according to claim 16 , wherein one of Rand Ris not aromatic in case of —NRRU; and one of Rand Ris not aromatic in case of —NRR; and one of Rand Ris not aromatic in case of —NRR; and one of Rand Ris not aromatic.21. The dye according to claim 16 , wherein R claim 16 , Rare independently of each other an alkyl group having from 1-8 carbon atoms.22. The dye according to claim 16 , wherein Ris in all cases independently selected from H and an alkyl group having from 1-8 carbon atoms.23. The dye according to claim 16 , having 1 claim 16 , 2 claim 16 , 3 or 4 linkers claim 16 , which are attached in the following positions: position R claim 16 , R claim 16 , or Rand R; in position R claim 16 , R claim 16 , or Rand R; or claim 16 , if the ring annulated to the pyrrol structure contains a N atom claim 16 , to this N atom.24. The dye according to claim 16 , having 1 or 2 linkers which are attached in the following positions: position R claim 16 , R claim 16 , or Rand R; in position R claim 16 , R claim 16 , or Rand R.25. The dye according to claim 16 , which is asymmetrical and does not have a C2 symmetry claim 16 , caused by different ring systems or by one or more substituents which are present only on one side of the molecule.27. A bioconjugate imaging agent according to claim 26 , wherein the targeting agents T are the same or different.28. A bioconjugate imaging agent according to claim 26 , linked to a biological target.29. A bioconjugate imaging agent according to claim 26 , linked to a biological target from the group transferrin claim 26 , proteins claim 26 , monoclonal ...

IR DYES FOR FLUORESCENCE IMAGING

A composition comprising: a polymorphic form of 2-((E)-2-((E)-3-(2-((E)-3,3-dimethyl-5-sulfonato-1-(4-sulfonatobutyl)indolin-2-ylidene)ethylidene)-2-phenoxycyclohex-1-en-1-yl)vinyl)-3,3-dimethyl-1-(4-ulfonatobutyl)-3H-indol- 1- ium-5-sulfonate or 2-((E)-2-((E)-3-(2-((E)-3,3-dimethyl-5-sulfonato-1-(4-sulfonatobutyl)indolin-2-ylidene)ethylidene)-2-(4-sulfonatophenoxy)cyclohex-1-en-1-yl)vinyl)-3,3-dimethyl-1-(4-sulfonatobutyl)-3H-indol-1-ium-5-sulfonate and an acceptable excipient. 2. The pharmaceutical composition of claim 1 , wherein the polymorphic form of Formula 1 is Form A.3. The pharmaceutical composition of claim 1 , wherein the polymorphic form of Formula 1 is Form B.4. The pharmaceutical composition of claim 1 , wherein the pharmaceutically acceptable excipient is a saccharide stabilizing agent.5. The pharmaceutical composition of claim 4 , wherein the saccharide stabilizing agent is a member selected from the group consisting of a monosaccharide claim 4 , a disaccharide or dextran.6. The pharmaceutical composition of claim 4 , wherein the saccharide stabilizing agent is a member selected from the group consisting of glucose claim 4 , galactose claim 4 , xylose claim 4 , glucuronic acid claim 4 , trehalose claim 4 , hydroxyethyl starch claim 4 , mannitol claim 4 , or 5% dextrose.7. The pharmaceutical composition of claim 6 , wherein the saccharide is mannitol.8. The pharmaceutical composition of claim 1 , wherein the composition further comprises a pharmaceutically acceptable carrier claim 1 , which is a member selected from the group consisting of physiological sterile saline solution claim 1 , sterile water solution claim 1 , pyrogen-free water solution claim 1 , isotonic saline solution claim 1 , and phosphate buffer solution.9. The pharmaceutical composition of claim 8 , wherein the composition is a lyophilized powder.10. The pharmaceutical composition of claim 9 , wherein the lyophilized composition is in a vial.11. The pharmaceutical composition of ...

IR DYES FOR FLUORESCENCE IMAGING

A method for organ imaging, comprising: administering to a subject a diagnostic effective amount of 2-((E)-2-((E)-3-(2-((E)-3,3-dimethyl-5-sulfonato-1-(4-sulfonatobutyl)indolin-2-ylidene)ethylidene)-2-phenoxycyclohex-1-en-1-yl)vinyl)-3,3-dimethyl-1-(4-sulfonatobutyl)-3H-indol-1-ium-5-sulfonate or 2-((E)-2-((E)-3-(2-((E)-3,3-dimethyl-5-sulfonato-1-(4-sulfonatobutyl)indolin-2-ylidene)ethylidene)-2-(4-sulfonatophenoxy)cyclohex-1-en-1-yl)vinyl)-3,3-dimethyl-1-(4-sulfonatobutyl)-3H-indol-1-ium-5-sulfonate. In one embodiment, the organ includes one or more of kidney, bladder, liver, gall bladder, spleen, intestine, heart, lungs and muscle. 2. The method of claim 1 , wherein the polymorphic form is Form A.3. The method of claim 1 , wherein the polymorphic form is Form B.4. The method of claim 1 , wherein the saccharide stabilizing agent is a member selected from the group consisting of a monosaccharide claim 1 , a disaccharide or dextran.5. The method of claim 4 , wherein the saccharide stabilizing agent is a member selected from the group consisting of glucose claim 4 , galactose claim 4 , xylose claim 4 , glucuronic acid claim 4 , trehalose claim 4 , hydroxyethyl starch claim 4 , mannitol claim 4 , or 5% dextrose.6. The method of claim 1 , wherein the pharmaceutical carrier is selected from the group consisting of physiological sterile saline solution claim 1 , sterile water solution claim 1 , pyrogen-free water solution claim 1 , isotonic saline solution claim 1 , and phosphate buffer solution.7. The method of claim 1 , wherein the administering is conducted at a diagnostic effective amount of the compound ranging between approximately 30.0 μg/kg and approximately 3000.0 μg/kg.8. The method of claim 1 , wherein the administering is conducted at a diagnostic effective amount of the compound ranging between approximately 35.0 μg/kg and approximately 600.0 μg/kg.9. The method of claim 1 , wherein the administering is conducted at a diagnostic effective amount of the ...

Device for controlling the passage of energy, containing a dichroic dye compound

The present application relates to a device for regulating the passage of energy from an outside space into an inside space, where the device comprises a switching layer comprising one or more dichroic dyes of a formula (I) or formula (II).

PHOTOELECTRIC CONVERSION ELEMENT, SOLAR CELL, AND COMPOSITION

Provided are a photoelectric conversion element, a solar cell using the photoelectric conversion element, and a composition. The photoelectric conversion element includes a first electrode including a photosensitive layer, which includes a light absorbing agent, on a conductive support. The light absorbing agent includes a compound having a perovskite-type crystal structure that includes organic cations represented by the following Formulae (1) and (2), a cation of a metal atom, and an anion. 2. The photoelectric conversion element according to claim 1 ,{'sup': '1', 'wherein in R, the alkyl group includes a substituent group, which is selected from the substituent-group group Z, other than an alkyl group.'}3. The photoelectric conversion element according to claim 1 ,{'sup': '1', 'wherein Rincludes at least one selected from the group consisting of an alkoxy group, an alkylthio group, and a halogen atom.'}4. The photoelectric conversion element according to claim 1 , {'br': None, '4≤[organic cation represented by Formula (2)]/[organic cation represented by Formula (1)]≤499.'}, 'wherein the amount of the organic cation that is contained and is represented by Formula (1), and the amount of the organic cation that is contained and is represented by Formula (2) satisfy a molar ratio relationship defined by the following expression,'}5. The photoelectric conversion element according to claim 1 , {'br': None, '19≤[organic cation represented by Formula (2)]/[organic cation represented by Formula (1)]≤199.'}, 'wherein the amount of the organic cation that is contained and is represented by Formula (1), and the amount of the organic cation that is contained and is represented by Formula (2) satisfy a molar ratio relationship defined by the following expression,'}6. A solar cell that uses the photoelectric conversion element according to .8. The composition according to claim 7 ,{'sup': '1', 'wherein in R, the alkyl group includes a substituent group, which is selected from ...

NOVEL METHINE DYES

The present invention relates to novel methine dyes, methods for the preparation thereof and use thereof for dyeing plastics, especially polyamides, so as to obtain yellow to orange colourings with improved light fastness and improved thermal stability. 2. The dye of claim 1 , wherein in formula (I){'sup': 1', '8, 'Ris hydrogen, fluorine, chlorine, COOH or COOR,'}{'sup': '2', 'sub': 1', '4', '3, 'Ris hydrogen, fluorine, chlorine, C-C-alkyl or CF,'}{'sup': 3', '9, 'Ris hydrogen, fluorine, chlorine, COORor CN,'}{'sup': '4', 'sub': 1', '4, 'Ris C-C-alkyl or phenyl'}{'sup': 5', '6, 'sub': 1', '4, 'Rand Rare each independently C-C-alkyl,'}{'sup': '7', 'sub': 1', '4', '3, 'Ris hydrogen, fluorine, chlorine, C-C-alkyl or CF,'}{'sup': '8', 'sub': 1', '4, 'Ris C-C-alkyl, and'}{'sup': '9', 'sub': 1', '4, 'Ris C-C-alkyl.'}3. The dye of claim 1 , wherein in formula (I){'sup': '1', 'sub': '3', 'Ris hydrogen, chlorine, COOH or COOCH,'}{'sup': '2', 'sub': '3', 'Ris hydrogen, chlorine, methyl, ethyl, n-propyl, isopropyl or CF,'}{'sup': '3', 'sub': '3', 'Ris hydrogen, fluorine, chlorine, COOCHor CN,'}{'sup': '4', 'Ris methyl or phenyl,'}{'sup': 5', '6, 'Rand Rare methyl, and'}{'sup': '7', 'sub': '3', 'Ris hydrogen, chlorine, methyl, ethyl, n-propyl, isopropyl or CF,'}4. The dye of claim 1 , wherein in formula (I){'sup': '1', 'sub': '3', 'Ris hydrogen, chlorine or COOCH,'}{'sup': '2', 'Ris hydrogen or methyl,'}{'sup': '3', 'Ris hydrogen, fluorine or chlorine,'}{'sup': '4', 'Ris methyl,'}{'sup': 5', '6, 'Rand Rare methyl and'}{'sup': '7', 'Ris hydrogen, chlorine or methyl.'}5. A method for the bulk colouration of plastic claim 1 , the method comprising adding one or more dyes of into plastic as colorants for the plastic.6. The method of claim 5 , wherein the plastic is one or more plastics selected from the group consisting of vinyl polymers claim 5 , polyesters claim 5 , polyolefins claim 5 , polycarbonates claim 5 , and polyamides.7. The method of claim 5 , wherein the plastics are ...

NOVEL METHINE DYES

The present invention relates to novel methine dyes, methods for the preparation thereof and use thereof for dyeing plastics, especially polyamides, so as to obtain yellow to orange colourings with improved light fastness and improved thermal stability. 2. The dye of claim 1 , wherein in formula (I){'sup': 1', '9, 'sub': 1', '4, 'Ris hydrogen, halogen, C-C-alkyl, which is optionally mono- to trisubstituted, identically or differently, by halogen, COOH or COOR,'}{'sup': '2', 'Ris oxygen or sulfur,'}{'sup': 3', '10, 'Ris hydrogen, halogen, COORor CN,'}{'sup': '4', 'sub': 1', '4, 'Ris C-C-alkyl or phenyl,'}{'sup': 5', '6, 'sub': 1', '4, 'Rand Rare each independently C-C-alkyl,'}{'sup': 7', '8', '11, 'sub': 1', '4, 'Rand Rare each independently hydrogen, halogen, C-C-alkyl, which is optionally mono- to trisubstituted, identically or differently, by methoxy or ethoxy, or COOR, and'}{'sup': 9', '10', '11, 'sub': 1', '4, 'R, Rand Rare each independently C-C-alkyl.'}3. The dye of claim 1 , wherein in formula (I){'sup': 1', '9, 'sub': '3', 'Ris hydrogen, fluorine, chlorine, CFor COOR,'}{'sup': '2', 'Ris oxygen or sulfur,'}{'sup': '3', 'Ris hydrogen, fluorine, chlorine or CN,'}{'sup': 4', '5', '6, 'R, Rand Rare each independently methyl or ethyl,'}{'sup': 7', '8, 'Rand Rare each independently hydrogen, each independently unsubstituted methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl or tert-butyl; or methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl or tert-butyl in each case mono- or disubstituted, identically or differently, by methoxy or ethoxy, and'}{'sup': '9', 'Ris methyl or ethyl.'}4. The dye of claim 1 , wherein in formula (I){'sup': 1', '9, 'sub': '3', 'Ris fluorine, chlorine, CFor COOR,'}{'sup': '2', 'Ris oxygen or sulfur,'}{'sup': '3', 'Ris hydrogen,'}{'sup': 4', '5', '6, 'R, Rand Rare each methyl,'}{'sup': 7', '8, 'Rand Rare each independently hydrogen, each independently unsubstituted methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl or tert-butyl or ...

NOVEL METHINE DYES

The present invention relates to novel methine dyes, methods for the preparation thereof and use thereof for dyeing plastics, especially polyamides, so as to obtain yellow to orange colourings with improved light fastness and improved thermal stability. 2. The dye of claim 1 , wherein in formula (I){'sup': 1', '11, 'Ris hydrogen, halogen, COOH or COOR,'}{'sup': 2', '12, 'Ris hydrogen, halogen, COORor CN,'}{'sup': '3', 'sub': 1', '4, 'Ris C-C-alkyl or phenyl,'}{'sup': 4', '5, 'sub': 1', '4, 'Rand Rare each independently C-C-alkyl,'}{'sup': 6', '7', '8', '9', '10', '13, 'sub': 1', '4', '1', '4, 'R, R, R, Rand Rare each independently hydrogen, halogen, C-C-alkyl, C-C-alkoxy or COOR, and'}{'sup': 11', '12', '13, 'sub': 1', '4, 'R, Rand Rare each independently C-C-alkyl.'}3. The dye of claim 1 , wherein in formula (I){'sup': 1', '11, 'Rs hydrogen, fluorine, chlorine, COOH or COOR,'}{'sup': 2', '12, 'Ris hydrogen, fluorine, chlorine, COORor CN,'}{'sup': '3', 'Ris methyl, ethyl, n-propyl or isopropyl,'}{'sup': 4', '5, 'Rand Rare each independently methyl, ethyl, n-propyl or isopropyl,'}{'sup': 6', '7', '8', '9', '10', '13, 'R, R, R, Rand Rare each independently hydrogen, fluorine, chlorine, methyl, ethyl, n-propyl, isopropyl, methoxy, ethoxy, or COOR, and'}{'sup': 11', '12', '13, 'R, Rand Rare each independently methyl, ethyl, n-propyl or isopropyl.'}4. The dye of claim 1 , wherein in formula (I){'sup': '1', 'sub': '3', 'Ris COOCH,'}{'sup': '2', 'Ris hydrogen,'}{'sup': '3', 'Ris methyl,'}{'sup': 4', '5, 'Rand Rare methyl, and'}{'sup': 6', '7', '8', '9', '10, 'R, R, R, Rand Rare each independently hydrogen, methyl, methoxy, ethoxy or chlorine.'}5. A method for the bulk colouration of plastic claim 1 , the method comprising adding one or more dyes of into plastic as colorants for the plastic.6. The method of claim 5 , wherein the plastic is one or more plastics selected from the group consisting of vinyl polymers claim 5 , polyesters claim 5 , polyolefins claim 5 , ...

HIGHLY FLUORESCENT PYRROLE-BF2 CHROMOPHORES

Fluorescent chromophores nicknamed BOPHY are provided. The chromophores may be readily synthesized in two steps from readily available reagents via the coupling of a pyrrole aldehyde or ketone with hydrazine, followed by reaction with BF. The resultant symmetric and dimeric tetracycle is comprised of two BFunits in six-member chelate rings, appended by pyrrole units on the periphery. The quantum yield of fluorescence for the unmodified compound and the tetramethyl variant are near unity, with values 95 and 92% respectively in CHCl. 1. A fluorescent compound that is prepared by the reaction of 1 ,2-bis((1H-pyrrol-2-yl)methylene)hydrazine with boron trifluoride in the presence of a sterically bulky base , wherein the compound includes at least one pyrrole ring and at least one imine group , and wherein the imine group includes at least one carbon atom that is bonded to a nitrogen atom via a double bond.2. The compound of claim 1 , further comprising one or more functional groups bonded to the at least one pyrrole ring.3. The compound of claim 1 , further comprising one or more functional groups bonded to the at least one carbon atom that is bonded to a nitrogen atom via a double bond.4. The compound of claim 1 , further comprising one or more aromatic groups bonded to the at least one pyrrole ring.5. The compound of claim 4 , wherein the aromatic group is a benzene ring.6. The compound of claim 4 , wherein the aromatic group is an azole group.7. The compound of claim 4 , wherein the aromatic group is a thiophene ring.9. The compound of claim 8 , further comprising one or more functional groups bonded to one or more carbon atoms.10. The compound of claim 8 , further comprising one or more aromatic groups bonded to one or more of the 5-member rings.11. The compound of claim 10 , wherein at least one of the one or more aromatic groups is a benzene ring.12. The compound of claim 10 , wherein at least one of the one or more aromatic groups is an azole group.13. The ...

Colored Resin Composition Exhibiting Pleochroism, and Molded Plastics Manufactured Using Same

The present invention relates to a coloring resin composition exhibiting pleochroism comprising 100 parts by weight of a transparent thermoplastic resin (A); 0.01 to 0.03 parts by weight of a dye for coloring a resin (B) which is one selected from the group consisting of an azo-based dye (b1), an anthraquinone-based dye (b2), and a methine dye (b3); and 0.1 to 0.3 parts by weight of a functional black dye (C) obtained by mixing an anthraquinone-based dye (c1) and a perinone-based dye (c2). A resin molded article manufactured by the coloring resin composition exhibiting pleochroism of the present invention is characterized by exhibiting different colors of light according to thicknesses although the resin molded article is irradiated with light sources in a single wavelength. 1. A resin molded article exhibiting pleochrosim wherein light transmitted through the molded article has different exhibited colors depending on the thickness of the molded article so that the molded article satisfies the following Mathematical Formula 1 or Mathematical Formula 2 in case of irradiation with a light source in a single wavelength:{'br': None, 'i': X', 'X', '−X, 'sub': 1', '2, 'Abs(Δ)=||>0.05\u2003\u2003[Mathematical formula 1]'}{'sub': '1', 'X=χ value of a CIE 1931 color space for the resin molded article with a thickness of 1.0 mm and'}{'sub': '2', 'claim-text': {'br': None, 'i': Y', 'Y', '−Y, 'sub': 1', '2, 'Abs(Δ)=||>0.05\u2003\u2003[Mathematical Formula 2]'}, 'X=χ value of a CIE 1931 color space for the resin molded article with a thickness of 1.5 mm,'}{'sub': '1', 'Y=y value of a CIE 1931 color space for the resin molded article with a thickness of 1.0 mm and'}{'sub': '2', 'Y=y value of a CIE 1931 color space for the resin molded article with a thickness of 1.5 mm.'}2. The resin molded article of claim 1 , wherein the resin molded article is prepared by a coloring resin composition comprising:a transparent thermoplastic resin;a dye for coloring a resin (B); anda functional ...

Theranostic conjugates

Provided herein is a drug delivery (DD) system for ratiometric luminescence determination of drug release degree in drug delivery monitoring, which includes a drug, a switchable reporter and non-switchable reporter providing two distinguishable signals for detection; or a single switchable reporter providing two distinguishable signals for detection, and a cleavable linker connecting a drug to a switchable reporter, as well as a method for ratiometric luminescence determination of drug release in a target (in vivo or in vitro), which is effected by administering the DD system provided herein that is capable of releasing a drug from the DD system, measuring two luminescent signals provided by the switchable reporter and the non-switchable reporter, or the single switchable reporter, determining the ratio between these two luminescence signals, and determining the drug release degree through the ratio between the two luminescence signals.

Application of reduced dyes in imaging

The present invention provides novel compounds and methods for hydrocyanines derived from near-infrared cyanine dyes, as reactive oxygen species probes in imaging. In certain embodiments, the present invention provides reduced dyes as substrates for ELISA and Western blots.

Small molecular probes, processes and use thereof

The present disclosure relates to compounds which function as small molecule fluorescent probes which aid in recognition of specific sequences in DNA and detection of Aβ aggregates. Probes/dyes of the instant disclosure are specific to AT-rich sequences of DNA and Aβ aggregates. These small organic dyes/probes are capable of exhibiting switch-on fluorescence and play an important role in fluorescence spectroscopy, diagnostics, imaging and biomedical applications.

Ir dyes for fluorescence imaging

A method for organ imaging, comprising: administering to a subject a diagnostic effective amount of 2-((E)-2-((E)-3-(2-((E)-3,3-dimethyl-5-sulfonato-1-(4-sulfonatobutyl)indolin-2-ylidene)ethylidene)-2-phenoxycyclohex-1-en-1-yl)vinyl)-3,3-dimethyl-1-(4-sulfonatobutyl)-3H-indol-1-ium-5-sulfonate or 2-((E)-2-((E)-3-(2-((E)-3,3-dimethyl-5-sulfonato-1-(4-sulfonatobutyl)indolin-2-ylidene)ethylidene)-2-(4-sulfonatophenoxy)cyclohex-1-en-1-yl)vinyl)-3,3-dimethyl-1-(4-sulfonatobutyl)-3H-indol-1-ium-5-sulfonate. In one embodiment, the organ includes one or more of kidney, bladder, liver, gall bladder, spleen, intestine, heart, lungs and muscle.

COMPOUND AND FLUORESCENTLY LABELED BIOLOGICAL SUBSTANCE USING THE SAME

Provided are any one of the following compounds and a fluorescently labeled biological substance having this compound. 3. The compound according to claim 2 ,wherein the compound is represented by any one of Formula (1-1), Formula (1-2), Formula (2-1), or Formula (2-2).4. The compound according to claim 1 ,{'sup': 1', '4, 'wherein Rto Rare an alkyl group which may have, as a substituent, a group selected from an alkoxy group, a carboxy group, an alkoxycarbonyl group, an acyloxy group, an aminocarbonyl group, an acylamino group, a sulfo group, and a phosphono group, and'}{'sup': 11', '12, 'Land Lare an alkyl group having, as a substituent, a group selected from an alkoxy group, a carboxy group, an alkoxycarbonyl group, an acyloxy group, an aminocarbonyl group, an acylamino group, a sulfo group, and a phosphono group,'}{'sup': 1', '4, 'provided that at least one of Rto Ris a sulfoalkyl group and in a case where the sulfoalkyl group has no substituent other than the sulfo group, at least one of the alkyl groups having only the sulfo group is a branched sulfoalkyl group.'}5. The invention according to claim 1 ,{'sup': 11', '12', '14', '15', '21', '23', '25', '27, 'wherein R, R, R, R, Rto R, and Rto Rare a hydrogen atom, and'}{'sup': 13', '24, 'Rand Rare a hydrogen atom or an alkyl group.'}6. The invention according to claim 1 ,{'sup': 1', '2, 'wherein at least one of Ror Ris an alkyl group having a substituent, and'}{'sup': 3', '4, 'at least one of Ror Ris an alkyl group having a substituent,'}{'sup': 1', '4, 'provided that at least one of Rto Ris a sulfoalkyl group and in a case where the sulfoalkyl group has no substituent other than the sulfo group, at least one of the alkyl groups having only the sulfo group is a branched sulfoalkyl group.'}7. The compound according to claim 1 ,{'sup': 11', '12, 'wherein Land Lare alkyl groups having at least one of a carboxy group and a sulfo group as a substituent.'}8. The compound according to claim 1 ,{'sup': 1', '4', '13', '11', ...

Modified biotin, streptavidin mutant, and usage of them

An object of this invention is to provide a streptavidin mutant reduced in affinity to the naturally-occurring biotin, and to provide a modified biotin which shows a high affinity to such streptavidin mutant reduced in affinity to the naturally-occurring biotin. This invention can provide a compound composed of a dimer of modified biotin, a streptavidin mutant, and usage of them.

ORGANIC DYE WITH IMPROVED EFFICIENCY AND USES THEREOF IN PHOTOVOLTAIC CELLS

An organic dye corresponding to one of the following structures (I) or (II): eD-pi-conjugated chromophore-L-A (I), or A-L-pi-conjugated chromophore-eD (II), where eD represents an electron donor segment, L represents a covalent bond or a spacer segment and in particular a pi-conjugated spacer segment, A represents an electron acceptor segment capable of forming a covalent bond with a semiconductor, in which the pi-conjugated chromophore comprises at least one unit of formula (III): 2) The organic dye according to claim 1 , wherein said pair (X claim 1 ,X) represents (S claim 1 ,S) claim 1 , (O claim 1 ,O) or (Se claim 1 ,Se) and in particular (S claim 1 ,S).3) The organic dye according to claim 1 , wherein in said unit (III) claim 1 , said radicals Rto Rare the same and/or the radicals Rand Rare the same claim 1 , said radicals Rto Rpreferably all representing a hydrogen and/or the radicals Rand Rpreferably all representing a hydrogen.4) The organic dye according to claim 1 , wherein in said unit (III) claim 1 , said radical Rrepresents a hydrogen.5) The organic dye according to claim 1 , wherein in said unit (III) claim 1 , said radicals Rand Rare the same and represent an optionally substituted aryl group and in particular an aryl group substituted by an optionally substituted alkyl group.7) The organic dye according to claim 1 , wherein said electron-donor segment (eD) is an amino group of (Z)(Z)N-type with Zand Z claim 1 , the same or different claim 1 , representing an optionally substituted alkyl group or optionally substituted aryl group.9) The organic dye according to claim 1 , wherein said spacer L is a pi-conjugated function such as an optionally substituted alkenylene or alkynylene chain and/or an optionally substituted arylene chain.11) Use of an organic dye such as defined in as photosensitizer in a photovoltaic device.12) Photovoltaic device having a nanostructured semiconductor metal oxide layer sensitized by at least one organic dye such as defined ...

POLYMERIZABLE NEAR-IR DYES

The present invention is directed, in certain embodiments, to polymerizable near-IR dyes and polymers comprising said dyes as monomeric residues. In other embodiments, the present invention also relates to methods for the preparation of polymerizable near-IR dyes, and to the use of polymerizable near-IR dyes in the preparation of fluorescent polymers. 2. (canceled)3. The polymerizable near-IR dye of claim 1 , wherein Zis O.415.-. (canceled)17. The polymerizable near-IR dye of claim 16 , wherein each Ror Ris claim 16 , independently claim 16 , C-Calkyl optionally substituted with SOH or B(OH).1824-. (canceled)2629-. (canceled)3134-. (canceled)3640-. (canceled)42. (canceled)43. (canceled)4250-. (canceled)5254-. (canceled)57. (canceled)59. (canceled)6168-. (canceled)7078-. (canceled)8084-. (canceled)86. (canceled)87. (canceled)8993-. (canceled)94. The polymer of claim 88 , wherein Ris methyl.95104-. (canceled)106111-. (canceled) The present application is a continuation of International Application No. PCT/US2017/067847, filed Dec. 21, 2017, which claims priority to U.S. Provisional Application No. 62/437,599 filed Dec. 21, 2016, each of which is incorporated herein by reference in their entireties for all purposes.Fluorescent polymers are functionalized macromolecules that find numerous applications in the fields of materials and life sciences and can be used as fluorescent probes, smart polymeric sensors, drug delivery carriers, and the like. Various methods of design and synthesis of fluorescent polymers have been developed in the art. Traditionally, fluorescent polymers are synthesized by chemical conjugation between activated fluorescent dye compounds and polymers bearing modifiable or reactive groups. This approach has several drawbacks: the activated dye derivatives are usually unstable and are prone to decomposition or side reactions, and the degree of polymer modification could be hard to control. To overcome these issues, methods of fluorescent polymer ...

FLUORESCENT POLYMETHINE CYANINE DYES

The invention encompasses fluorescent cyanine dyes and methods of using such dyes. In particular, the invention encompasses near infrared polymethine cyanine dyes. 2. The fluorescent cyanine dye of claim 1 , wherein X is selected from the group consisting of heteroatom claim 1 , alkenyl claim 1 , and alkynyl.3. The fluorescent cyanine dye of claim 1 , wherein Ris SONa and Ris H.4. The fluorescent cyanine dye of claim 1 , wherein Rand Rare (CH═CH).5. The fluorescent cyanine dye of claim 1 , wherein the heteroatom is selected from the group consisting of nitrogen claim 1 , oxygen claim 1 , sulfur and selenium.6. The compound of claim 1 , further comprising a biomolecule conjugated to the aryl.7. The compound of claim 6 , wherein the biomolecule is selected from the group consisting of an antigen claim 6 , an antibody claim 6 , a drug claim 6 , a vitamin claim 6 , and a small molecule.8. The compound of claim 6 , wherein the biomolecule is selected from the group consisting of a peptide claim 6 , a nucleic acid claim 6 , a carbohydrate claim 6 , and a lipid.9. The compound of claim 8 , wherein the biomolecule is a peptide. This application is a divisional application of U.S. Ser. No. 13/712,317, filed on Dec. 12, 2012, which is a divisional application of U.S. Ser. No. 12/192,480, filed on Aug. 15, 2008, now U.S. Pat. No. 8,344,158 issued on Jan. 1, 2013, which claims the benefit of U.S. provisional application No. 60/955,908, filed Aug. 15, 2007, hereby incorporated by reference in its entirety.The present invention was supported by the National Institute of Health Grant Nos. R01 EB 1430 and R01 CA 109754. The United States Government has certain rights in this invention.The invention encompasses stable near-infrared cyanine dyes and methods of using such dyes.Molecules that absorb and emit light in the near-infrared (NIR) wavelengths have become the central focus of numerous analytical, biological, and spectroscopic studies because their spectral, chemical, and ...

Halogenated compounds for photodynamic therapy

Halo-organic heterocyclic compounds are described, in which at least two halogen atoms are bound to a nitrogen-containing heterocyclic terminal moiety of the compound, with at least one of such halogen atoms being iodine or bromine. Also described are polymethine dyes based on these heterocyclic compounds, and dendrimeric compounds and conjugates of such polymethine dyes. The polymethine dyes are characterized by enhanced properties, e.g., brightness, photostability, sensitivity and/or selective affinity that make them useful to target cancer cells, pathogenic microorganisms, and/or other biological materials, in applications such as photodynamic therapy, photodynamic antimicrobial chemotherapy (PACT), cancer treatment, selective removal or attachment of biological materials, antimicrobial coating materials, and other diagnostic, theranostic, spectrum shifting, deposition/growth, and analytic applications.

NOVEL METHINE DYES

Novel red methine dyes, methods for the preparation thereof, and use thereof for dyeing plastics, especially vinyl polymers, provide red colourings with improved colour strengths and improved colour brilliance. 2. The dye of claim 1 , wherein:{'sup': 1', '7, 'Ris hydrogen, halogen, COOH or COOR,'}{'sup': '2', 'sub': 1', '4, 'Ris hydrogen or is C-C-alkyl, optionally mono- to trisubstituted, identically or differently, by halogen and/or hydroxyl,'}{'sup': 3', '8, 'Ris hydrogen, halogen, CN, COOH or COOR,'}{'sup': '4', 'sub': 1', '4, 'Ris C-C-alkyl or phenyl,'}{'sup': 5', '6, 'sub': 1', '4, 'Rand Rare each independently C-C-alkyl, and'}{'sup': 7', '8, 'sub': 1', '4, 'Rand Rare each independently C-C-alkyl.'}3. The dye of claim 1 , wherein:{'sup': 1', '7, 'Ris hydrogen, fluorine, chlorine, COOH or COOR,'}{'sup': '2', 'sub': '3', 'Ris hydrogen, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl or tert-butyl, hydroxymethyl, hydroxyethyl or CF,'}{'sup': 3', '8, 'Ris hydrogen, fluorine, chlorine, CN or COOR,'}{'sup': '4', 'Ris methyl or phenyl,'}{'sup': 5', '6, 'Rand Rare each independently methyl or ethyl, and'}{'sup': 7', '8, 'Rand Rare each independently methyl or ethyl.'}4. The dye of claim 1 , wherein:{'sup': '1', 'sub': '3', 'Ris hydrogen, fluorine, chlorine or COOCH,'}{'sup': '2', 'Ris n-butyl, isobutyl, tert-butyl or hydroxyethyl,'}{'sup': '3', 'Ris hydrogen, fluorine or chlorine, and'}{'sup': 4', '5', '6, 'R, Rand Rare each methyl.'}5. The dye of claim 4 , wherein Rand Rare not both hydrogen.6. A method for the bulk colouration of plastics claim 1 , the method comprising coloring plastic with one or more dyes of .7. The method of claim 6 , wherein the plastic is one or more plastics selected from vinyl polymers claim 6 , polyesters and polycarbonates.8. The method of claim 7 , wherein the plastic is polystyrene claim 7 , polymethyl methacrylate (PMMA) claim 7 , polyethylene terephthalate or polycarbonate.9. The method of claim 6 , wherein the dye is used in an ...

OPTICAL FILTER AND IMAGING DEVICE

An optical filter includes an absorption layer containing a near-infrared absorbing dye with an absorption characteristic in dichloromethane satisfying (i-1) to (i-3). (i-1) In an absorption spectrum of a wavelength of 400 to 800 nm, there is a maximum absorption wavelength λin 670 to 730 nm. (i-2) Between a maximum absorption coefficient εof light with a wavelength of 430 to 550 nm and a maximum absorption coefficient εof light with a wavelength of 670 to 730 nm, the following relational expression: ε/ε≥65 is established. (i-3) In a spectral transmittance curve, the difference between a wavelength λwith which the transmittance becomes 80% on a shorter wavelength side than the maximum absorption wavelength with the transmittance at the maximum absorption wavelength λset to 10% and the maximum absorption wavelength λis 65 nm or less. 121-. (canceled)23. The squarylium-based dye according to claim 22 , wherein{'sup': 13', '14', '15', '13', '14', '15, 'in the formula (4-2), either one of R, Rand Ra hydrogen atom, or none of R, Rand Rare hydrogen atoms.'}24. The squarylium-based dye according to claim 22 , wherein{'sup': 13', '14', '15, 'in the formula (4-2), two or more of R, Rand Rare alkyl groups having 1 to 4 carbon atoms.'}26. The squarylium-based dye according to claim 25 , wherein{'sup': 7', '8, 'in the formula (3), Ris independently an alkyl group or alkoxy group having 1 to 6 carbon atoms which optionally have a branch, and Ris independently a hydrogen atom or an alkyl group or alkoxy group having 1 to 6 carbon atoms which optionally have a branch.'}28. The squarylium-based dye according to claim 22 , wherein{'sup': '2', 'in the formula (AI), Ris independently an alkyl group or alkoxy group having 1 to 12 carbon atoms which optionally have a branch, or a hydrocarbon group having 6 to 16 carbon atoms which contains an unsaturated ring structure.'}29. A resin film claim 22 , comprising:{'claim-ref': {'@idref': 'CLM-00022', 'claim 22'}, 'the squarylium-based dye ...

POLYMETHINE COMPOUNDS AND THEIR USE AS FLUORESCENT LABELS

The present disclosure relates to new compounds and their use as fluorescent labels. The compounds may be used as fluorescent labels for nucleotides in nucleic acid sequencing applications. 1. A compound of the formula (I) or mesomeric forms thereof:wherein mCat+ or mAn− is an organic or inorganic positively/negatively charged counterion andm is an integer 0-3;p is an integer 1-2;q is an integer 1-5;alk is a chain of 1-5 carbon atoms optionally containing one or more double or triple bonds;{'sub': '2', 'Y is S, O or CH;'}Z is OH;n is an integer 0-3;{'sup': '−', 'X is OH or O or an amide or ester conjugate thereof;'}{'sub': 1', '2', '3, 'sup': '−', 'each of Raand Rais independently H, SO, sulfonamide, halogen, or a further ring fused to an adjacent carbon atom; and'}{'sub': 1', '2', '1', '2', '3', '1', '2', '3', '1', '2, 'sup': −', '−, 'each of Rcand Rcis independently alkyl or substituted alkyl, wherein at least one of Raor Rais SO, or Raor Rais a further ring fused to an adjacent carbon atom, the further ring having an SO, or Rcor Rcis an alkyl sulfonic acid group.'} The present application is a continuation of U.S. application Ser. No. 15/762,073, filed Mar. 21, 2018, which is a U.S. national phase under 35 U.S.C. § 371 of International Patent Application No. PCT/GB2016/052986, filed Sep. 26, 2016, which claims the benefit of priority to United Kingdom (GB) Appl. No. 1516987.3, filed Sep. 25, 2015, each of which is incorporated by reference in its entirety.The present disclosure relates to new polymethine compounds and their use as fluorescent markers. In particular the compounds may be used as fluorescent labels for nucleotides in nucleic acid sequencing applications.Several publications and patent documents are referenced in this application in order to more fully describe the state of the art to which this disclosure pertains. The disclosure of each of these publications and documents is incorporated by reference herein.Non-radioactive detection of nucleic ...

Methine-Substituted Cyanine Dye Compounds

Cyanine dye compounds having a substituted methine moiety that are nucleic acid stains, particularly for fluorescent staining of RNA, including compounds having the formula where R 1 is a C 1 -C 6 alkyl, sulfoalkyl, carboxyalkyl or C 1 -C 6 alkoxy; each R 2 is independently selected from the group consisting of H, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, fused benzo, trifluoromethyl, amino, sulfo, carboxy and halogen, that is optionally further substituted; at least one of R 3 , R 4 , and R 5 is an alkyl, aryl, heteroaryl, cyclic, or heterocyclic moiety that is optionally substituted by alkyl, amino, aminoalkyl, carboxy, nitro, or halogen; and the remaining R 3 , R 4 or R 5 are hydrogen; X is S, O, or Se; and D is a substituted or unsubstituted pyridinium, quinolinium or benzazolium moiety.

Optical filter

To provide an optical filter having shielding effects against near ultraviolet rays and near infrared rays. An optical filter comprising a transparent resin body having a single layer or multilayer structure, and containing a near ultraviolet absorbing dye (U) which is a compound represented by the following formula (U) and which has an absorption maximum at a wavelength of from 370 to 425 nm and has a molar absorptivity at the maximum absorption wavelength of at least 50,000 [L/(mol·cm)], and a near infrared absorbing dye (A) which has an absorption maximum at a wavelength of from 600 to 800 nm: In the formula (U), Y is an oxygen atom, a methylene group or a dimethylene group, R 1 is a monovalent hydrocarbon group which may have a substituent, or the like, R 2 to R 5 are a hydrogen atom, an alkyl group, an alkoxy group or the like, and X is a bivalent group represented by any one of the formulae (X1) to (X5) or the like.

LITHOGRAPHIC PRINTING PLATE PRECURSOR AND PLATE-MAKING METHOD USING SAME

Provided are a thermal fusion-type lithographic printing plate precursor in which the visibility is excellent, ablation during laser exposure is suppressed, and the contamination of dampening water and printing ink during on-machine development is suppressed by a lithographic printing plate precursor having a support and an image-recording layer, in which the image-recording layer is capable of forming an image by infrared laser exposure, a non-exposed portion of the image-recording layer is removable by at least one of dampening water and printing ink on a printer, and the image-recording layer contains (1) a color developing system in which a hue change generated by infrared laser exposure is Δa/Δb≥0.6 and (2) 70% by mass or more of a thermoplastic polymer particle with respect to a solid content of the image-recording layer and a plate-making method in which the thermal fusion-type lithographic printing plate precursor is used. 1. A lithographic printing plate precursor comprising:a support; andan image-recording layer,wherein the image-recording layer is capable of forming an image by infrared laser exposure, a non-exposed portion of the image-recording layer is removable by at least one of dampening water and printing ink on a printer, and the image-recording layer contains (1) a color developing system in which a hue change generated by infrared laser exposure is Δa/Δb≥0.6 and (2) 70% by mass or more of a thermoplastic polymer particle with respect to a solid content of the image-recording layer.2. The lithographic printing plate precursor according to claim 1 ,wherein the image-recording layer contains 80% by mass or more of the thermoplastic polymer particle with respect to the solid content of the image-recording layer.3. The lithographic printing plate precursor according to claim 1 ,wherein the image-recording layer contains 90% by mass or more of the thermoplastic polymer particle with respect to the solid content of the image-recording layer.4. The ...

HALOGENATED COMPOUNDS FOR PHOTODYNAMIC THERAPY

Halo-organic heterocyclic compounds are described, in which at least two halogen atoms are bound to a nitrogen-containing heterocyclic terminal moiety of the compound, with at least one of such halogen atoms being iodine or bromine. Also described are polymethine dyes based on these heterocyclic compounds, and dendrimeric compounds and conjugates of such polymethine dyes. The polymethine dyes are characterized by enhanced properties, e.g., brightness, photostability, sensitivity and/or selective affinity that make them useful to target cancer cells, pathogenic microorganisms, and/or other biological materials, in applications such as photodynamic therapy, photodynamic antimicrobial chemotherapy (PACT), cancer treatment, selective removal or attachment of biological materials, antimicrobial coating materials, and other diagnostic, theranostic, spectrum shifting, deposition/growth, and analytic applications. 3. The dendrimeric compound of claim 1 , of formula 1.4. The dendrimeric compound of claim 1 , of formula 2.5. The dendrimeric compound of claim 1 , of formula 3.6. The dendrimeric compound of claim 1 , of formula 4.7. The dendrimeric compound of claim 1 , of formula 5.8. The dendrimeric compound of claim 1 , of formula 6.9. The dendrimeric compound of claim 1 , of formula 7.10. The dendrimeric compound of claim 1 , of formula 8.11. The dendrimeric compound of claim 1 , of formula 9.12. The dendrimeric compound of claim 1 , of formula 10.13. The dendrimeric compound of claim 1 , of formula 11.14. The dendrimeric compound of claim 1 , of formula 12.15. The dendrimeric compound of claim 1 , of formula 13.16. The dendrimeric compound of claim 1 , of formula 14.17. The dendrimeric compound of claim 1 , of formula 15.18. The dendrimeric compound of claim 1 , of formula 16.19. The dendrimeric compound of claim 1 , of formula 17.20. The dendrimeric compound of claim 1 , of formula 18.21. The dendrimeric compound of claim 1 , of formula 19.22. The dendrimeric compound of ...

MODIFIED CARBOCYANINE DYES AND THEIR CONJUGATES

Chemically reactive carbocyanine dyes incorporating an indolium ring moiety that is substituted at the 3-position by a reactive group or by a conjugated substance, and their uses, are described. Conjugation through this position results in spectral properties that are uniformly superior to those of conjugates of spectrally similar dyes wherein attachment is at a different position. The invention includes derivative compounds having one or more benzo nitrogens. 2. The compound of claim 1 , wherein Y represents the atoms necessary to form two fused aromatic rings.3. The compound of claim 1 , wherein the atoms of Y are selected from —CH and —C.4. The compound of claim 1 , wherein X is —CRR.5. The compound of claim 4 , wherein Ris C-Calkyl.6. The compound of claim 4 , wherein Ris methyl.7. The compound of claim 1 , wherein α is 1.8. The compound of claim 1 , wherein Ris C-Calkyl.9. The compound of claim 8 , wherein Ris methyl or ethyl.10. The compound of claim 1 , wherein W represents the atoms necessary to form two fused aromatic rings.11. The compound of claim 1 , wherein the atoms of W are selected from —CH and —C.12. The compound of claim 1 , wherein Z is —CRR.13. The compound of claim 12 , wherein each of Rand Ris methyl.14. The compound of claim 1 , wherein δ is 1.15. The compound of claim 1 , wherein Ris methyl or ethyl.16. The compound of claim 1 , wherein a is 1 and b is 0.17. The compound of claim 1 , wherein Ris a phosphoramidite.21. The compound of claim 1 , wherein L comprises ether bonds.22. The compound of claim 1 , wherein L contains 4-10 nonhydrogen atoms claim 1 , including one or two heteroatoms.23. The compound of claim 1 , wherein L contains 1-6 carbon atoms. This application is a divisional of U.S. Ser. No. 14/656,992, filed Mar. 14, 2015, which is a continuation of co-pending U.S. Ser. No. 14/030,835, filed Sep. 18, 2013 to issue as U.S. Pat. No. 9,018,396 on Apr. 28, 2015, which is a continuation of U.S. Ser. No. 13/556,643, filed Jul. 24, 2012 ( ...

OPTICAL FILTER, SOLID-STATE IMAGING ELEMENT, IMAGING DEVICE LENS AND IMAGING DEVICE

The present invention relates to an optical filter, a solid-state imaging element and an imaging device lens which contain a near infrared ray absorbing layer having a specific near infrared ray absorbing dye dispersed in a transparent resin having a refractive index of 1.54 or more, and also relates to an imaging device containing the solid-state imaging element or the imaging device lens. The near infrared ray absorbing layer has a transmittance of visible light of from 450 to 600 nm of 70% or more, a transmittance of light in a wavelength region of from 695 to 720 nm of not more than 10%, and an amount of change of transmittance of not more than −0.8. 121.-. (canceled)23. The optical filter according to claim 22 , wherein the selective wavelength shielding layer transmits visible light in a wavelength range of from 420 to 695 nm therethrough and shields light in a wavelength range of from 720 to 1 claim 22 ,100 nm.24. The optical filter according to claim 22 , wherein the first dielectric multilayer film transmits visible light having a wavelength of from 420 to 695 nm therethrough claim 22 , the near infrared ray absorbing layer has the near infrared ray absorbing range at wavelengths of 710 nm or greater in which a transmittance of light is not more than 5% claim 22 , and a wavelength at a shorter wavelength end of the first reflecting range is equal to or shorter than a wavelength at a longer wavelength end of the infrared light absorbing range of the near infrared ray absorbing layer.25. The optical filter according to claim 22 , wherein the second dielectric multilayer film transmits visible light in a wavelength range of from 420 to 695 nm therethrough claim 22 , the second dielectric multilayer film reflects in a wavelength range of 400 nm or shorter claim 22 , a wavelength at a shorter wavelength end of the second reflecting range is equal to or shorter than a wavelength at a longer wavelength end of the first reflecting range claim 22 , and a wavelength ...

Holographic media containing chain-substituted cyanine dyes

The present invention relates to a photopolymer composition comprising a photopolymerizable component and a photoinitiator system comprising a chain-substituted cyanine dye. The invention further provides a photopolymer comprising a photopolymer composition according to the invention, a holographic medium comprising a photopolymer according to the invention, the use of a holographic medium according to the invention, and a process for producing a holographic medium by using the photopolymer according to the invention and the exposure of the corresponding holographic medium with the aid of pulsed laser radiation.

MULTIMERIC PROTECTED FLUORESCENT REAGENTS

Multimeric protected fluorescent reagents and their methods of synthesis are provided. The reagents are useful in various fluorescence-based analytical methods, including the analysis of highly multiplexed optical reactions in large numbers at high densities, such as single molecule real time nucleic acid sequencing reactions. The reagents contain fluorescent dye elements, that allow the compounds to be detected with high sensitivity at desirable wavelengths, binding elements, that allow the compounds to be recognized specifically by target biomolecules, and protective shield elements, that decrease undesirable contacts between the fluorescent dye elements and the bound target biomolecules and that therefore decrease photodamage of the bound target biomolecules by the fluorescent dye elements. The reagents also contain coupling elements connect monomeric compounds into multimeric forms, thereby increasing brightness. 1. A reagent of structural formula (IV):{'br': None, 'sub': m′', 'q, 'J-[-B″—S″—Z—[—S′—B′]]\u2003\u2003(IV); wherein'}each Z is independently a multivalent central core element comprising a fluorescent dye element;each S′ is independently an intermediate chemical group, wherein at least one S′ comprises a shield element;each S″ is independently an intermediate chemical group, wherein S″ optionally comprises a shield element;each B′ is independently a terminal chemical group, wherein at least one B′ comprises a binding element;each B″ is independently a terminal chemical group or a bond;J is a joining element;each m′ is independently an integer from 1 to 23; andq is an integer from 2 to 10.2. The reagent of claim 1 , wherein the shield element decreases photodamage of the reagent or of a biomolecule associated with the binding element.3. The reagent of claim 1 , wherein the shield element decreases contact between the fluorescent dye and the binding element.4. The reagent of claim 1 , wherein the shield element comprises a plurality of side chains.516-. ...

DYES FOR LABELLING MOLECULAR LIGANDS

Cyanine dyes with improved fluorescence intensity and photostability. The present invention relates generally to fluorescent dye reagents.Fluorescent dyes are widely used for labeling, detecting, and quantifying components in a sample. Analytical methods that utilize such dye reagents include fluorescence microscopy, fluorescence immunoassay, flow cytometric analysis of cells, and various other applications. The choice of fluorescent dyes is particularly important in applications that utilize multiplex, multicolor analysis.Many fluorescent dyes currently used in aqueous systems have a tendency to form dimers or aggregate compromising their performance. Moreover, many dyes in current use exhibit poor chemical and/or photochemical stability. Thus, there is a continued need for the development of new fluorescent dye compounds. The present invention satisfies this need and provides related benefits as well.In some aspects, embodiments disclosed herein relate to a compound of formula I:In other aspects, embodiments disclosed herein relate to a method of making the aforementioned compounds of formula I. The method includes condensing a compound comprising formula IIA or IIB:wherein Z=OR, SR, NHR or NR; w=0, 1, 2, 3with a compound comprising formula IIIA or IIIB appropriately:wherein Yis NHR, NRR, or XR, (where X=O, S); w is 1, 2 or 3.To improve yield of unsymmetrical dye structure I from starting materials IIA and IIIB, synthesis may achieved by a two-step reaction with preliminary formation of hemicyanines IIB and IIIA.The present invention is directed, in part, to a fluorescent dye compound of formula I:Fluorescent dyes of the invention can be used as markers in many different ways for the analysis of a major part of clinically, biologically, biochemically or chemically relevant substances, such as for example cells, antibodies, proteins, hormones, nucleic acids, oligonucleotides, naturally occurring or modified nucleotides, carbohydrates and some others.Fluorescent ...

OPTICAL FILTER

To provide an optical filter having shielding effects against near ultraviolet rays and near infrared rays. An optical filter comprising a transparent resin body having a single layer or multilayer structure, and containing a near ultraviolet absorbing dye (U) which is a compound represented by the following formula (U) and which has an absorption maximum at a wavelength of from 370 to 425 nm and has a molar absorptivity at the maximum absorption wavelength of at least 50,000 [L/(mol·cm)], and a near infrared absorbing dye (A) which has an absorption maximum at a wavelength of from 600 to 800 nm: 1. An optical filter comprising a transparent resin body comprising a transparent resin and having a single layer or multilayer structure , wherein the transparent resin body contains a near ultraviolet absorbing dye (U) which has an absorption maximum at a wavelength of from 370 to 425 nm and a near infrared absorbing dye (A) which has an absorption maximum at a wavelength of from 600 to 800 nm , the optical filter has a wavelength λ(U50) at which the transmittance is 50% in a wavelength band of from 400 to 440 nm , and the optical filter satisfies the following requirements (1) , (2) and (4) to (8):(1) there are a wavelength λ(UV15) at which the transmittance is 15% and a wavelength λ(UV70) at which the transmittance is 70% in a wavelength band of from 380 to 450 nm, and λ(UV70)−λ(UV15)≤30 nm,(2) there are a wavelength λ(IR15) at which the transmittance is 15% and a wavelength λ(IR70) at which the transmittance is 70% in a wavelength band of from 600 15 to 720 nm, and λ(IR15)−λ(IR70)≤60 nm, and(4) in a spectral transmittance curve at an angle of incidence of 0°, the average transmittance in a wavelength band of from 430 to 620 nm is at least 80%,(5) in a spectral transmittance curve at an angle of incidence of 0°, the average transmittance in a wavelength band of from 350 to 395 nm is at most 3%,(6) in a spectral transmittance curve at an angle of incidence of 0°, the ...

Modified carbocyanine dyes and their conjugates

Chemically reactive carbocyanine dyes incorporating an indolium ring moiety that is substituted at the 3-position by a reactive group or by a conjugated substance, and their uses, are described. Conjugation through this position results in spectral properties that are uniformly superior to those of conjugates of spectrally similar dyes wherein attachment is at a different position. The invention includes derivative compounds having one or more benzo nitrogens.

Photoelectric conversion element, dye-sensitized solar cell, metal complex dye, dye solution, dye-adsorbed electrode, and method for producing dye-sensitized solar cell

A photoelectric conversion element, having a photoconductor layercontaining semiconductor fine particles carrying a metal complex dye of Formula (I); a metal complex dye, a dye solution, a dye-adsorbed electrode, a dye-sensitized solar cell, and a method for producing the solar cell: M ( LA )( LD )( LX ) mX ·( CI ) mY   Formula (I) M represents a metal ion, LA represents a ligand of Formula (AL), LD represents a bidentate or tridentate ligand, at least one of coordinating atoms being an anion; LX represents a monodentate ligand; CI represents a counter ion; mX is 0 or 1; mY is 0 to 3; Rings A to C represent a heterocycle; Z 1 and Z 2 represent a carbon or nitrogen atom; Anc1 to Anc3 represent an acidic group; X 1 to X 3 represent a single bond or linking group; R 1 to R 3 represent a substituent; l1, l3, l2, m1, m3, m2, n1, n2, and n3 each are an integer.

Dye for Dyeing Cotton Fiber in Supercritical Carbon Dioxide, Preparation Method and Application Thereof

The present disclosure discloses a dye for industrialization of dyeing cotton fiber in supercritical carbon dioxide that can react with cotton fiber, wherein a preparation method therefor comprises the following steps: dissolving a hydroxyl-containing natural dye in an organic solvent, dropwise adding an alcohol compound containing a halogen group into a reaction system in the presence of an acid-binding agent, precipitating the product with another solvent after the reaction is completed, and then filtrating and drying to obtain the compound described. The obtained compound is used for dyeing cotton fiber in supercritical carbon dioxide. The dye provided by the present disclosure is capable of dyeing cotton fiber in supercritical carbon dioxide conditions, and has a better color fastness while dyeing the cotton fiber.

CYANINE DYES

The invention provides a novel class of cyanine dyes that are functionalized with sulfonic acid groups and a linker moiety that facilitates their conjugation to other species and substituent groups which increase the water-solubility, and optimize the optical properties of the dyes. Also provided are conjugates of the dyes, methods of using the dyes and their conjugates and kits including the dyes and their conjugates. 122.-. (canceled)24. The compound according to claim 23 , having the formula:29. The compound according to claim 23 , wherein M comprises biotin.30. The compound according to claim 29 , wherein biotin is bound to streptavidin.31. The compound according to claim 23 , wherein a member selected from R claim 23 , R claim 23 , R claim 23 , R claim 23 , R claim 23 , R claim 23 , Rand Ris a moiety comprising poly(ethylene glycol).32. The compound according to in which two claim 23 , three claim 23 , four claim 23 , five or six of R claim 23 , R claim 23 , R claim 23 , R claim 23 , R claim 23 , R claim 23 , Rand R claim 23 , in any combination claim 23 , include an independently selected dye moiety or dye linker moiety.33. The compound according to in which two claim 23 , three claim 23 , four claim 23 , five or six of R claim 23 , R claim 23 , R claim 23 , R claim 23 , R claim 23 , R claim 23 , Rand R claim 23 , in any combination claim 23 , include an independently selected polyvalent moiety.34. The compound according to wherein said polyvalent moiety has bound thereto one or more member selected from a dye claim 23 , a dye-linker moiety claim 23 , and a nucleotide polyphosphate.35. A method of monitoring an enzyme reaction claim 23 , said method comprising:{'claim-ref': {'@idref': 'CLM-00023', 'claim 23'}, '(a) forming a reaction mixture by contacting said enzyme with a fluorescent dye according to wherein said dye is a substrate for said enzyme under conditions sufficient for said enzyme and said dye to react; and'}(b) monitoring fluorescence of said ...

COMPOSITION, METHOD, SYSTEM AND KIT FOR OPTICAL ELECTROPHYSIOLOGY

The present invention provides a method of optical electrophysiological probing, including: providing a fluorescing chemical probe; contacting a thick portion of tissue with the fluorescing chemical probe to create a thick portion of treated tissue; applying a first range of wavelengths of electromagnetic radiation to the treated portion of tissue; and detecting a plurality of depth-specific emission wavelengths emitted from the thick portion of treated tissue. 3. The composition of claim 1 , further comprising a delivery agent that is at least one of a physiologically acceptable adjuvant claim 1 , solvent claim 1 , substrate claim 1 , or diluent.4. The composition of claim 3 , wherein the delivery agent is selected from the group consisting of: Pluronic F-127 claim 3 , Pluronic L64 claim 3 , cyclodextrin claim 3 , gamma cyclodextrin claim 3 , dimethylsulfoxide claim 3 , ethanol claim 3 , and combinations thereof. This application is a continuation of U.S. patent application Ser. No. 13/442,407, filed Apr. 9, 2012, which is a continuation of U.S. patent application Ser. No. 11/923,282, filed Oct. 24, 2007, now U.S. Pat. No. 8,155,730, which claims priority to U.S. Patent Application No. 60/854,418, filed Oct. 24, 2006, the disclosures of each of which are incorporated herein by reference.This invention was made with government support under contract identifier EB-001963 awarded by the National Institute of Health and contract identifier HL-071635 and HL-7163501 awarded by the National Heart Lung and Blood Institute. The government has certain rights in the invention.1. Technical FieldThe present invention relates various embodiments of a composition, method, system, and kit for optical electrophysiology. More specifically, the present invention relates to enhanced mapping (and/or optical imaging) of thick tissue with novel near infrared probes (voltage-sensitive dyes) having high voltage sensitivity, including said composition, method, system, and kit for advanced ...

ORGANIC DYE FOR A DYE-SENSITIZED SOLAR CELL

Organic dye for a dye-sensitized solar cell (DSSC) comprising at least one electron-acceptor unit and at least one π-conjugated unit. Said organic dye is particularly useful in a dye-sensitized photoelectric transformation element which, in its turn, can be used in a dye-sensitized solar cell (DSSC). 3: A dye-sensitized photoelectric transformation element comprising the organic dye of claim 1 , wherein the dye-sensitized photoelectric transformation element is supported on oxide semiconductor particles.4: A dye-sensitized solar cell comprising the dye-sensitized photoelectric transformation element of .5: A dye-sensitized photoelectric transformation element comprising the organic dye of claim 2 , wherein the dye-sensitized photoelectric transformation element is supported on oxide semiconductor particles.6: A dye-sensitized solar cell comprising the dye-sensitized photoelectric transformation element of . The present invention relates to an organic dye for a dye-sensitized solar cell (DSSC).More in particular, the present invention relates to an organic dye for a dye-sensitized solar cell (DSSC) comprising at least one electron-acceptor unit and at least one η-conjugated unit.Said organic dye is particularly useful in a dye-sensitized photoelectric transformation element which, in its turn, can be used in a dye-sensitized solar cell (DSSC).Consequently, it is a further object of the present invention a dye-sensitized photoelectric transformation element comprising the organic dye above reported, as well as a dye-sensitized solar cell (DSSC) comprising said photoelectric transformation element.Dye-sensitized solar cells (DSSCs) have been developed by Gratzel et al. on 1991 and they have attracted considerable attention in recent years due to their high efficiency and remarkably low manufacture cost compared to the existing silicon solar cells.The dye-sensitized solar cells (DSSCs) are photoelectrochemical solar cells mainly comprising organic dye molecules capable ...

METHOD OF QUENCHING SINGLET AND TRIPLET EXCITED STATES OF PHOTODEGRADABLE PIGMENTS, SUCH AS PORPHYRIN COMPOUNDS, PARTICULARLY PROTOPORPHYRIN IX, WITH CONJUGATED FUSED TRICYCLIC COMPOUNDS HAVING ELECTRON WITHDRAWING GROUPS, TO REDUCE GENERATION OF SINGLET OXYGEN

A method of quenching excited state energy from a photodegradable pigment that has been excited by absorption of light having a wavelength in the wavelength range of 290-800 nm, comprising reacting a pigment with a conjugated fused tricyclic compound having electron withdrawing groups of Formula (II) or a salt thereof: 1. (canceled)526-. (canceled)28. The cosmetic or dermatological composition of claim 27 , wherein the compound of Formula IIb claim 27 , IIc claim 27 , IId claim 27 , IIe claim 27 , IIf claim 27 , IIg claim 27 , IIh claim 27 , IIi claim 27 , IIk claim 27 , IIl claim 27 , IIm claim 27 , IIn claim 27 , or a combination thereof claim 27 , is present in an amount of about 0.01% by weight to about 20% by weight claim 27 , based on the total weight of the composition.29. The cosmetic or dermatological composition of further comprising an additional photoactive compound selected from the group consisting of p-aminobenzoic acid and salts and derivatives thereof; anthranilate and derivatives thereof; salicylate and derivatives thereof; cinnamic acid and derivatives thereof; dihydroxycinnamic acid and derivatives thereof; camphor and salts and derivatives thereof; trihydroxycinnamic acid and derivatives thereof; dibenzalacetone naptholsulfonate and salts and derivatives thereof; benzalacetophenone naphtholsulfonate and salts and derivatives thereof; dihydroxy-naphthoic acid and salts thereof; o-hydroxydiphenyldisulfonate and salts and derivatives thereof; p-hydroxdydiphenyldisulfonate and salts and derivatives thereof; coumarin and derivatives thereof; diazole derivatives; quinine derivatives and salts thereof; quinoline derivatives; hydroxyl-substituted benzophenone derivatives; naphthalate derivatives; methoxy-substituted benzophenone derivatives; uric acid derivatives; vilouric acid derivatives; tannic acid and derivatives thereof; hydroquinone; benzophenone derivatives; 1 claim 27 , 3 claim 27 , 5-triazine derivatives; phenyldibenzimidazole tetrasulfonate ...

CHALCOGENOPYRYLIUM DYES, COMPOSITIONS COMPRISING SAME, COMPOSITE NANOPARTICLES COMPRISING SAME, AND METHODS OF MAKING AND USING THE SAME

The present disclosure provides chalcogenopyrylium compounds, composite nanostructures comprising the chalcogenopyrylium compounds, and methods of using the compounds and/or composite nanostructures. For example, composite nanostructures comprising the chalcogenopyrylium compounds are used in imaging applications. The present disclosure provides chalcogenopyrylium compounds having the following structure where each E is, at each occurrence in the compound, independently charged or neutral and is independently selected from S, Se, 0, or Te, wherein at least one E is S or Se; each R1 is, at each occurrence in the compound, independently selected from the group consisting of —H, Ci-s alkyl group, halo group, —CN, aryl group, and heteroaryl group and adjacent R1 groups can combine to form C5ss aryl groups, each R2 is, at each occurrence in the compound. 4. A composite nanostructure comprising:a core comprising a nanomaterial;{'claim-ref': {'@idref': 'CLM-00001', 'claim 1'}, 'one or more reporter molecules having the structure of , wherein each of the reporter molecules is independently, at each occurrence in the composite nanostructure, directly covalently bound to the core or covalently bound to the core via a linking group to the core; and'}optionally, an encapsulating material that at least partially encapsulates the core and the one or more reporter molecules.5. The composite nanostructure of claim 4 , wherein the core comprises a metal nanomaterial.6. The composite nanostructure of claim 4 , wherein the core is a hollow gold nanoshell.7. The composite nanostructure of claim 4 , wherein the nanomaterial is a nanoparticle and the nanoparticle size is 15 to 300 nm.8. The composite nanostructure of claim 4 , wherein the nanostructure morphology is selected from the group consisting of sphere claim 4 , rod claim 4 , star claim 4 , raspberry claim 4 , and hollow shell.9. The composite nanostructure of claim 4 , wherein the encapsulating material is an inorganic material ...

Latent additive and composition containing latent additive

A latent additive represented by general formula (1): wherein A is a 5- or 6-membered aromatic or heterocyclic ring; R 1 and R 2 are each hydrogen, halogen, cyano, hydroxyl, nitro, carboxyl, optionally substituted C1-C40 alkyl, C6-C20 aryl, C7-C20 arylalkyl, or C2-C20 heterocyclic ring-containing group; and R 4 is C1-C20 alkyl, C2-C20 alkenyl, C6-C20 aryl, C7-C20 arylalkyl, C2-C20 heterocyclic ring-containing group, or trialkylsilyl.

POLYMETHINE COMPOUNDS AND THEIR USE AS FLUORESCENT LABELS

The present disclosure relates to new compounds and their use as fluorescent labels. The compounds may be used as fluorescent labels for nucleotides in nucleic acid sequencing applications. 2. A compound according to wherein where n is 0 claim 1 , Y is S or O.3. A compound according to or wherein (alk) is (CH).4. A compound according to any one of to wherein p is 1.5. A compound according to any one of to wherein p is 2.6. A compound according to any one of to wherein Rais H or SO.7. A compound according to any one of to wherein Rais H or SO.8. A compound according to any one of to wherein Rais a further ring fused to an adjacent carbon atom.9. A compound according to any one of to wherein Rais a further ring fused to an adjacent carbon atom.10. A compound according to any one preceding claim wherein Rcor Rcis methyl claim 1 , ethyl claim 1 , propyl or —(CH)SO where t is 1-6.11. A compound according to wherein either Rcor Rcis (CH)—SO.12. A compound according to any one preceding claim wherein Y is O.13. A compound according to any one preceding claim wherein n is 0.14. A compound according to any one preceding claim wherein n is 1.15. A compound according to wherein the OH group is in the 4-position.19. A compound according to any preceding claim wherein the compound is attached to a nucleotide or oligonucleotide.20. A nucleotide or oligonucleotide labelled with a compound according to -.21. A labelled nucleotide or oligonucleotide according to wherein the label is attached via an amide linkage formed from the C(═O)—X moiety.22. A labelled nucleotide or oligonucleotide according to or wherein the label is attached to the C5 position of a pyrimidine base or the C7 position of a 7-deaza purine base through a linker moiety.23. A labelled nucleotide or oligonucleotide according to any one of - claim 18 , further comprising a 3′ OH blocking group covalently attached to the ribose or deoxyribose sugar of the nucleotide.24. A kit comprising two or more nucleotides wherein ...

Compositions of Near IR Closed Chain, Sulfo-Cyanine Dyes and Prostate Specific Membrane Antigen Ligands

Compositions and methods for visualizing tissue under illumination with fusion compounds of near-infrared radiation using near IR, closed chain, sulfo-cyanine dyes and prostate specific membrane antigen ligands are provided.

Liquid crystal display device and color filter substrate of the same

A color filter substrate is disclosed, including a substrate, a black matrix disposed on the substrate and multiple color resist blocks separated by the black matrix and disposed on the substrate. Each color resist block is filled with a color resist material, the color resist material includes pigment molecules, including at least one photosensitive substituent. A liquid crystal display device having the same is also disclosed. Utilizing an UV irradiation step in the CF process, the pigment molecules are aligned directionally, which can increase the transmittance of the color filter substrate, the utilization rate of the backlight, and decrease the power consumption. Under the same display brightness, the thickness of the color filter substrate can be decreased; the pigment molecules aligned directionally can make an emitting light to be along a same direction to reduce the light interference between adjacent sub-pixels having different colors to greatly decrease the color shift.

Scaffold-based polymerase enzyme substrates

The invention provides a novel class of scaffold-based labeled polymerase enzyme substrates. The polymerase enzyme substrates have a multivalent core or scaffold to which is attached fluorescent dye moieties and nucleoside phosphate moities. The polymerase enzyme substrates have multiple fluorescent dye moities and/or multiple nucleoside phosphate moieties. Preferred multivalent cores comprise trifunctional six membered aromatic moities. The invention also provides for sequencing methods and kits with scaffold-based labeled polymerase enzyme substrates.

PHOTOELECTRIC CONVERSION ELEMENT AND IMAGE SENSOR USING SAME

A photoelectric conversion element, including a first electrode, a second electrode, and at least one organic layer being present between the first electrode and the second electrode, in which the organic layer contains at least two kinds of compounds having the same skeletons and different substituents in combination. 2. The photoelectric conversion element according to claim 1 ,{'sup': 1', '8, 'wherein adjacent groups among Rto Rare bonded to each other in general formula (3), and form a condensed ring including 3 to 6 rings in total.'}3. The photoelectric conversion element according to claim 2 ,wherein general formula (3) has a ring structure selected from among anthracene, phenanthrene, naphthacene, pyrene, chrysene, triphenylene, fluoranthene, benzofluoranthene, perylene, pentacene, and hexacene.4. The photoelectric conversion element according to claim 1 ,{'sub': 1', '1', '2', '2', '1', '2', '1', '2, 'wherein ionization potential (Ip) and electron affinity (Ea) of the compound represented by general formula (1), and ionization potential (Ip) and electron affinity (Ea) of the compound represented by general formula (2) are Ip Подробнее

INFRARED-SENSITIVE COLOR DEVELOPING COMPOSITION, LITHOGRAPHIC PRINTING PLATE PRECURSOR, PLATE MAKING METHOD FOR LITHOGRAPHIC PRINTING PLATE, AND INFRARED-SENSITIVE COLOR DEVELOPER

Objects are to provide an infrared-sensitive color developing composition which develops colors in a high density by means of infrared exposure and does not significantly discolor when aged, to provide a lithographic printing plate precursor which has extremely excellent plate-inspecting properties and favorable storage stability and is capable of maintaining favorable color-developing properties and a plate making method for a lithographic printing plate in which the lithographic printing plate precursor is used, and to provide a new compound that can be preferably used as an infrared-sensitive color developer. 4. The infrared-sensitive color developing composition according to claim 1 , further comprising:a binder polymer (Component B).5. The infrared-sensitive color developing composition according to claim 1 , further comprising:a polymerization initiator (Component C).6. The infrared-sensitive color developing composition according to claim 1 , further comprising:a polymerizable compound (Component D).8. The lithographic printing plate precursor according to claim 7 ,wherein the image-recording layer further contains polymer particles.9. The lithographic printing plate precursor according to claim 7 , comprising:a protective layer on the image-recording layer.10. The lithographic printing plate precursor according to claim 9 ,wherein the protective layer contains an inorganic lamellar compound.11. A plate making method for a lithographic printing plate claim 9 , comprising:{'claim-ref': {'@idref': 'CLM-00007', 'claim 7'}, 'a preparation step of preparing the lithographic printing plate precursor according to ;'}an exposure step of exposing the lithographic printing plate precursor in an image pattern; andan on-machine development process step of removing non-image portions by supplying printing ink and dampening water to the lithographic printing plate precursor that has been exposed in an image pattern on a printer.13. The compound according to claim 12 ,{'sup ...

MULTIMERIC PROTECTED FLUORESCENT REAGENTS

Multimeric protected fluorescent reagents and their methods of synthesis are provided. The reagents are useful in various fluorescence-based analytical methods, including the analysis of highly multiplexed optical reactions in large numbers at high densities, such as single molecule real time nucleic acid sequencing reactions. The reagents contain fluorescent dye elements, that allow the compounds to be detected with high sensitivity at desirable wavelengths, binding elements, that allow the compounds to be recognized specifically by target biomolecules, and protective shield elements, that decrease undesirable contacts between the fluorescent dye elements and the bound target biomolecules and that therefore decrease photodamage of the bound target biomolecules by the fluorescent dye elements. The reagents also contain coupling elements connect monomeric compounds into multimeric forms, thereby increasing brightness. 1. A method of using a reagent of structural formula{'br': None, 'sub': m′', 'q, 'J\ue8a0B″—S″—Z\ue8a0S′—B′\ue8a0\ue8a0\u2003\u2003(IV);'}(IV) in a fluorescence-based assay: each Z is independently a multivalent central core element comprising a fluorescent dye element;', 'each S′ is independently an intermediate chemical group, wherein at least one S′ comprises a shield element;', 'each S″ is independently an intermediate chemical group, wherein S″ optionally comprises a shield element;', 'each B′ is independently a terminal chemical group, wherein at least one B′ comprises a binding element;', 'each B″ is independently a terminal chemical group or a bond;', 'J is a joining element;', 'each m′ is independently an integer from 1 to 23; and', 'q is an integer from 2 to 10, 'wherein'}comprising the step of measuring fluorescence of the reagent of structural formula (IV).2. The method of claim 1 , wherein the shield element decreases photodamage of the reagent or of a biomolecule associated with the binding element.3. The method of claim 1 , wherein the ...

CONTACT LENS AND CONTACT LENS PRODUCT

A contact lens includes at least one color changeable region, wherein the color changeable region includes at least one photoluminescence material. When a wavelength of the photoluminescence material having a maximum radiation intensity is WEmMx, an average transmittance in a wavelength range of 400 nm-700 nm of the color changeable region is T4070, a size of a total area of the color changeable region is AC, and a size of a total area of the contact lens is AL, certain conditions relating to WEmMx, T4070 and AC/AL are satisfied. 1. A contact lens , comprising:at least one color changeable region, wherein the color changeable region comprises at least one photoluminescence material; [{'br': None, 'i': 'WEmMx', '400 nm≤≤600 nm;'}, {'br': None, 'i': 'T', '85%≤4070; and'}, {'br': None, 'i': 'AC/AL≤', '0.001≤1.0.'}], 'wherein a wavelength of the photoluminescence material having a maximum radiation intensity is WEmMx, an average transmittance in a wavelength range of 400 nm-700 nm of the color changeable region is T4070, a size of a total area of the color changeable region is AC, a size of a total area of the contact lens is AL, and the following conditions are satisfied2. The contact lens of claim 1 , wherein the photoluminescence material is a curcumin or a curcuminoid.4. The contact lens of claim 3 , wherein at least one of the R claim 3 , Rand Rof the side chains of —X—R claim 3 , —X—Rand —X—Ris an unsaturated carbon chain.5. The contact lens of claim 3 , wherein the carbon number of the side chain of the photoluminescence material is NC claim 3 , and the following condition is satisfied:{'br': None, 'i': 'NC≤', '1≤10.'}6. The contact lens of claim 3 , wherein the carbon number of the side chain of the photoluminescence material is NC claim 3 , and the following condition is satisfied:{'br': None, 'i': 'NC≤', '11≤18.'}7. The contact lens of claim 3 , wherein at least one of the —X—R claim 3 , —X—Rand —X—Rcomprises an ether group (—O—).8. The contact lens of claim 3 ...

Functionalized Cyanine Dyes (PEG)

The invention provides a novel class of cyanine dyes that are functionalized with a linker moiety that facilitates their conjugation to other species and substituent groups which increase the water-solubility, and optimize the optical properties of the dyes. Also provided are conjugates of the dyes, methods of using the dyes and their conjugates and kits including the dyes and their conjugates. 133.-. (canceled)35. The compound according to claim 34 , wherein X claim 34 , Xand Xare independently selected from S claim 34 , SC(O)NH claim 34 , HNC(O)S claim 34 , SC(O)O claim 34 , O claim 34 , NH claim 34 , NHC(O) claim 34 , (O)CNH and NHC(O)O claim 34 , and OC(O)NH claim 34 , CHS claim 34 , CHO claim 34 , CHCHO claim 34 , CHCHS claim 34 , (CH2)O claim 34 , (CH)S and (CH)Y′-PEGwherein, Y′ is selected from S, NH, NHC(O), C(O)NH, NHC(O)O, OC(O)NH, and O; ando is an integer from 1 to 50.38. The compound according to claim 34 , wherein at least two of R claim 34 , R claim 34 , R claim 34 , and Rare alkylsulfonic acid.39. The compound according to claim 34 , wherein neither Rnor Ris unsubstituted alkyl.40. The compound according claim 34 , wherein when two Rmoieties are not joined to form said ring substituted with said at least one SOH moiety claim 34 , at least one Ris SOH.41. The compound according to claim 34 , wherein when two Rmoieties are not joined to form said aryl ring substituted with said at least one SOH moiety claim 34 , at least one Ris SOH.58. The compound according to in which two claim 34 , three claim 34 , four claim 34 , five or six of R claim 34 , R claim 34 , R claim 34 , R claim 34 , R claim 34 , R claim 34 , R claim 34 , R claim 34 , R claim 34 , and Rin any combination claim 34 , include an independently selected dye moiety or dye linker moiety.59. The compound according to in which two claim 34 , three claim 34 , four claim 34 , five or six of R claim 34 , R claim 34 , R claim 34 , R claim 34 , R claim 34 , R claim 34 , R claim 34 , R claim 34 , R ...

Modified carbocyanine dyes and their conjugates

Chemically reactive carbocyanine dyes incorporating an indolium ring moiety that is substituted at the 3-position by a reactive group or by a conjugated substance, and their uses, are described. Conjugation through this position results in spectral properties that are uniformly superior to those of conjugates of spectrally similar dyes wherein attachment is at a different position. The invention includes derivative compounds having one or more benzo nitrogens.

YELLOW METHINE DYES

The present invention relates to novel methine dyes, methods for the preparation thereof and use thereof for dyeing plastics, especially polyamides, so as to obtain yellow colorings with improved light fastness and improved thermostability. 2. The methine dye as claimed in claim 1 , wherein:{'sup': '4', 'sub': 1', '4, 'Ris straight-chain or branched C-C-alkyl or phenyl,'}{'sup': 5', '6, 'sub': 1', '4, 'Rand Rare each independently straight-chain or branched C-C-alkyl,'}{'sup': '7', 'sub': 1', '4, 'Ris straight-chain or branched C-C-alkyl, and'}{'sup': '8', 'sub': 1', '4, 'Ris straight-chain or branched C-C-alkyl.'}3. The methine dye as claimed in claim 1 , wherein:{'sup': '1', 'sub': '3', 'Ris hydrogen, fluorine, chlorine, COOH or COOCH,'}{'sup': '2', 'sub': '3', 'Ris hydrogen, fluorine, chlorine, CF, or CN,'}{'sup': '3', 'sub': '3', 'Ris hydrogen, chlorine, COOCHor CN,'}{'sup': '4', 'Ris methyl or phenyl, and'}{'sup': 5', '6, 'Rand Rare methyl.'}4. The methine dye as claimed in claim 1 , wherein for formula (I):{'sup': 1', '2', '3', '4', '5', '6, 'sub': 3', '3', '3, 'Ris —COOCH, Rand Rare Cl, Ris —CH, and Rand Rare —CH, or'}{'sup': 1', '2', '3', '4', '5', '6, 'sub': 3', '3', '3, 'Ris —COOCH, Ris H, Ris Cl, Ris —CH, and Rand Rare —CH, or'}{'sup': 1', '2', '3', '4', '5', '6, 'sub': 3', '3', '3, 'Ris —COOCH, Ris Cl, Ris H, Ris —CH, and Rand Rare —CH, or'}{'sup': 1', '2', '3', '4', '5', '6, 'sub': 3', '3', '3', '3, 'Ris —COOCH, Ris H, Ris —COOCH, Ris —CH, and Rand Rare —CH, or'}{'sup': 1', '2', '3', '4', '5', '6, 'sub': 3', '3', '3, 'Ris —COOCH, Ris H, Ris CN, Ris —CH, and Rand Rare —CH, or'}{'sup': 1', '2', '3', '4', '5', '6, 'sub': 3', '3', '3, 'Ris —COOCH, Ris F, Ris H, Ris —CH, and Rand Rare —CH, or'}{'sup': 1', '2', '3', '3', '4', '5', '6, 'sub': 3', '3', '3, 'Ris —COOCH, Ris CF, Ris H, Ris —CH, and Rand Rare —CH, or'}{'sup': 1', '2', '3', '4', '5', '6, 'sub': 3', '3, 'Ris —Cl, Rand Rare Cl, Ris —CH, and Rand Rare —CH, or'}{'sup': 1', '2', '3', '4', '5', '6, 'sub ...

METHODS FOR DYE SELECTION FOR PROTEIN MELT TEMPERATURE DETERMINATIONS

According to the present teachings, compositions, kits, and methods for protein melt analysis are provided that utilizing one or more fluorophore dyes. In some embodiments, a method comprises preparing a sample by mixing at least one protein with two or more dyes, and applying a controlled heating, while recording the fluorescence emission of the sample. The methods can be used, for example, for screening conditions for optimized protein stability, screening for ligands that bind and enhance protein stability (e.g., protein-protein interactions), screening for mutations for enhanced stability, screening crystallization conditions for protein stability, screening storage conditions for protein stability, and screening conditions in which a protein will be used (e.g., production conditions, treatment conditions, etc.) for protein stability. 2. The method of claim 1 , wherein the sample solution mixture is formed when the at least one protein is in its native state.3. The method of claim 1 , wherein when the at least one protein is present in its native state claim 1 , then each of the at least two fluorophore dyes is configured to provide at least a minimally fluorescent signal and when the at least one protein is present in an unfolded state claim 1 , then each of the at least two fluorophore dyes is configured to provide a substantially increased fluorescent signal.4. The method of claim 1 , wherein the measuring step is performed in the presence of a filter.5. The method of claim 1 , wherein each of the at least two fluorophore dyes are spectrally distinct.6. The method of claim 1 , wherein at least one of the mixture of at least two fluorophore dyes is Nile Red.7. The method of claim 1 , further comprising the step of (d) calculating a Tof the at least one protein using the measured fluorescence.8. The method of claim 1 , wherein the sample solution mixture further comprises a ligand which is configured to form a protein/ligand complex with the at least one ...

NOVEL METHINE DYES

The present invention relates to novel methine dyes, methods for the preparation thereof and use thereof for dyeing plastics, especially polyamides, so as to obtain yellow to orange colourings with improved light fastness and improved thermal stability. 2. The method of claim 1 , wherein in formula (I){'sup': 1', '9, 'sub': '3', 'Ris hydrogen, fluorine, chlorine, CFor COOR,'}{'sup': '2', 'Ris oxygen or sulfur,'}{'sup': '3', 'Ris hydrogen, fluorine, chlorine or CN,'}{'sup': 4', '5', '6, 'R, Rand Rare each independently methyl or ethyl,'}{'sup': 7', '8, 'Rand Rare each independently hydrogen, each independently unsubstituted methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl or tert-butyl; or methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl or tert-butyl in each case mono- or disubstituted, identically or differently, by methoxy or ethoxy, and'}{'sup': '9', 'Ris methyl or ethyl,'}{'sup': 1', '3, 'where Rand Rare not both hydrogen.'}3. The method of claim 1 , wherein in formula (I){'sup': 1', '9, 'sub': '3', 'Ris fluorine, chlorine, CFor COOR,'}{'sup': '2', 'Ris oxygen or sulfur,'}{'sup': '3', 'Ris hydrogen,'}{'sup': 4', '5', '6, 'R, Rand Rare each methyl,'}{'sup': 7', '8, 'Rand Rare each independently hydrogen, each independently unsubstituted methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl or tert-butyl or 1-methyl-2-methoxyethyl, and'}{'sup': '9', 'Ris methyl.'}4. The method of claim 1 , wherein the plastic is selected from the group consisting of vinyl polymers claim 1 , polyesters claim 1 , polyolefins claim 1 , polycarbonates claim 1 , and polyamides.5. The method of claim 1 , wherein the plastic is nylon-6 and/or nylon-6.6.6. The method of claim 1 , wherein the method further comprises adding to the plastic an amount of 0.0001 to 1 percent by weight of the dyes claim 1 , based on the amount of plastic.7. The method of claim 1 , wherein the method further comprises adding to the plastic an amount of 0.01 to 0.5 percent by weight of the dyes claim 1 ...

OPTICAL FILTER AND IMAGING DEVICE

The present invention relates to an optical filter containing: an absorption layer containing a near-infrared absorbing dye (A) having a maximum absorption wavelength in dichloromethane being in a wavelength range of 850 to 1,100 nm and a transparent resin; and a reflection layer formed of a dielectric multilayer film, in which the near-infrared absorbing dye (A) satisfies the following Formulae (1) to (4). 1. An optical filter comprising: an absorption layer comprising a near-infrared absorbing dye (A) satisfying the following (i-1) to (i-3) and a transparent resin; and a reflection layer formed of a dielectric multilayer film:{'sub': 'max(A) DCM', '(i-1) a maximum absorption wavelength λis in a wavelength range of 850 to 1,100 nm in an absorbance curve of wavelength 350 to 1,200 nm measured in dichloromethane;'}{'sub': max(A)DCM', 'λmax(A) DCM', '400 (A) DCM', '550 (A) DCM, 'claim-text': [{'br': None, 'sub': 400(A)DCM', 'λmax(A)DCM, 'ABS/ABS<0.10\u2003\u2003(1), and'}, {'br': None, 'sub': 550(A)DCM', 'λmax(A)DCM, 'ABS/ABS<0.04\u2003\u2003(2); and'}], '(i-2) in the absorbance curve of wavelength 350 to 1,200 nm measured in dichloromethane, when an absorbance at the maximum absorption wavelength λis denoted by ABS, an absorbance at a wavelength of 400 nm is denoted by ABS, and an absorbance at a wavelength of 550 nm is denoted by ABS, the following Formulae (1) and (2) are satisfied{'sub': max(A) TR', 'max(A)TR', 'λmax(A) TR', '400 (A) TR', '550 (A) TR, 'claim-text': [{'br': None, 'sub': 400 (A) TR', 'λmax(A) TR, 'ABS/ABS<0.15\u2003\u2003(3), and'}, {'br': None, 'sub': 550(A)TR', 'λmax(A)TR, 'ABS/ABS<0.10\u2003\u2003(4).'}], '(i-3) in an absorbance curve of the wavelength of 350 to 1,200 nm measured in the transparent resin, a maximum absorption wavelength λis in a wavelength range of 850 to 1,100 nm, and when an absorbance at the maximum absorption wavelength λis denoted by ABS, an absorbance at the wavelength of 400 nm is denoted by ABS , and an absorbance at the ...

Photopolymer formula for producing of holographic media with highly networked matrix polymers

Photopolymer formulation comprises a polyol component, a polyisocyanate component, a writing monomer and a photoinitiator comprising a co-initiator and a dye (I), where (I) exhibits a water absorption of = 5%. Photopolymer formulation comprises a polyol component, a polyisocyanate component, a writing monomer and a photoinitiator comprising a co-initiator and a dye of formula (F1 +>An ->) (I), where (I) exhibits a water absorption of = 5%. F1 : a cationic dye, preferably acridine, xanthene, thioxanthene, phenazine, phenoxazine, phenothiazine, tri(het)arylmethane, preferably diamino-and triamino(het)arylmethane, mono-, di-, tri-methine cyanine, hemicyanine, merocyanine external cationic merocyanine, external cationic neutrocyanine, nullmethine, preferably naphtholactam or streptocyanine dyes; and An -> : anion, preferably P, B, S (preferably SO 3 ->), 8-25C, preferably 13-25C-alkane sulfonate, 3-18C, preferably 4-18C-perfluoroalkanesulfonate, 9-25C-alkanoate, 9-25C-alkeneoate, 8-25C, preferably 13-25C-alkyl sulfate, 8-25C, preferably 13-25C-alkenyl sulfate, 3-18C, preferably 4-18C-perfluoroalkylsulfate, polyethersulfate based on at least 4 equivalents of ethylene oxide and/or propylene oxide, bis-4-25C-alkyl, 5-7C-cycloalkyl, 3-8C-alkenyl, 7-11C-aralkyl-sulfosuccinate, bis-2-10C-alkyl sulfosuccinate substituted by at least 8 F, 8-25C-alkyl sulfoacetates, benzene sulfonate substituted by halo, 4-25C-alkyl, perfluoro-1-8C alkyl and/or 1-12C-alkoxycarbonyl, or naphthalene or biphenylsulfonate (optionally substituted by nitro, CN, OH, 1-25C-alkyl, 1-12C-alkoxy, amino, 1-12C-alkoxycarbonyl or Cl), or benzene, naphthalene or biphenyldisulfonate (optionally substituted by nitro, CN, OH, 1-25C-alkyl, 1-12C-alkoxy, 1-12C-alkoxy or Cl), benzoate (substituted by dinitro, 6-25C-alkyl, 4-12C-alkoxycarbonyl, benzoyl, toluoyl or chlorobenzoyl), naphthalene dicarboxylic acid anion, diphenyletherdisulfonate, sulfonated or sulfated, optionally at least mono-unsaturated 8- ...

Quinolinium dyes with fluorinated counter anion for dye sensitized solar cells

The present invention relates to an electrode layer comprising a porous film made of oxide semiconductor fine particles sensitized with a quinolinium dye having a fluorinated counteranion. Moreover the present invention relatesto a photoelectric conversion device comprising said electrode layer, a dye sensitized solar cell comprising said photoelectric conversion device and to novel quinolinium dyes having a fluorinated counteranion.

Method for labeling and detecting materials employing arylsulfonate cyanine dyes

A luminescent cyanine dye having generally the following structure ##STR1## wherein the dotted lines represent one to three rings having 5 to 6 atoms in each ring. R 3 , R 4 , R 8 and R 9 groups are attached to the rings. At least one of the R 8 and R 9 groups is a sulfonic acid or sulfonate group and at least one of the R 1 , R 2 , R 3 , R 4 and R 7 groups is a reactive moiety that reacts with amino, hydroxy or sulfhydryl nucleophiles.

Fluorescent labeling complexes with large stokes shift formed by coupling together cyanine and other fluorochromes capable of resonance energy transfer

The present invention provides low molecular weight fluorescent labeling complexes with large wavelength shifts between absorption of one dye in the complex and emission from another dye in the complex. These complexes can be used, for example, for multiparameter fluorescence cell analysis using a single excitation wavelength. The low molecular weight of the complex permits materials labeled with the complex to penetrate cell structures for use as probes. The labeling complexes are synthesized by covalently attaching through linkers at least one cyanine fluorochrome to another low molecular weight fluorochrome to form energy donor-acceptor complexes. Resonance energy transfer from an excited donor to fluorescent acceptor provides wavelength shifts up to 300 nm. The fluorescent labeling complexes preferably contain reactive groups for the labeling of functional groups on target compounds, such as derivatized oxy and deoxy polynucleic acids, antibodies, enzymes, proteins and other materials. The complexes may also contain functional groups permitting covalent reaction with materials containing reactive groups.

Compounds for fluorescence labeling

Fluorescent compounds usable in determining a DNA sequence, assaying a physiologically active substance by the fluorescent immunoassay method, etc. Compounds represented by general formula (I) or salts thereof (wherein V?1 to V5 ¿represent each hydrogen, halogeno, alkyl, alkenyl, a group selected from a group consisting of groups capable of forming a covalent bond together with a substance to be labeled, etc., or V?1 and V2¿ may be bonded to each other to form a saturated or unsaturated ring; R1 represents hydrogen or a group selected from a group consisting of alkyl, aryl and heterocyclic groups; R?3 and R4¿ represent each alkyl, or R?3 and R4¿ may be bonded to each other to form a ring; Q represents atoms which are necessary in forming a methine chromophore; and m and n represent each 0 or 1, provided that m+n is 1.

Modified carbocyanine dyes and their conjugates

Chemically reactive carbocyanine dyes incorporating an indolium ring moiety that is substituted at the 3-position by a reactive group or by a conjugated substance, and their uses, are described. Conjugation through this position results in spectral properties that are uniformly superior to those of conjugates of spectrally similar dyes wherein attachment is at a different position. The invention includes derivative compounds having one or more benzo nitrogens.

Method for labeling and detecting materials employing arylsulfonate cyanine dyes

A method for detecting a component of an aqueous liquid comprising adding to the liquid a luminescent dye selected from the group consisting of cyanine, merocyanine and styryl dyes containing at least one sulfonic acid or sulfonate group attached to an aromatic nucleus and reacting the dye with the component. The labeled component is then detected by an optical detection method.

Method for labeling and detecting materials employing arylsulfonate cyanine dyes

A method for detecting a component of an aqueous liquid comprising adding to the liquid a luminescent dye selected from the group consisting of cyanine, merocyanine and styryl dyes containing at least one sulfonic acid or sulfonate group attached to an aromatic nucleus and reacting the dye with the component. The labeled component is then detected by an optical detection method.

Reagents including a carrier and fluorescent labeling complexes with large stokes shift formed by coupling together cyanine and other fluorochromes capable of resonance energy transfer

The present invention provides low molecular weight fluorescent labeling complexes with large wavelength shifts between absorption of one dye in the complex and emission from another dye in the complex. These complexes can be used, for example, for multiparameter fluorescence cell analysis using a single excitation wavelength. The low molecular weight of the complex permits materials labeled with the complex to penetrate cell structures for use as probes. The labeling complexes are synthesized by covalently attaching through linkers at least one cyanine fluorochrome to another low molecular weight fluorochrome to form energy donor-acceptor complexes. Resonance energy transfer from an excited donor to fluorescent acceptor provides wavelength shifts up to 300 nm. The fluorescent labeling complexes preferably contain reactive groups for the labeling of functional groups on target compounds, such as derivatized oxy and deoxy polynucleic acids, antibodies, enzymes, proteins and other materials. The complexes may also contain functional groups permitting covalent reaction with materials containing reactive groups.

Modified carbocyanine dyes and their conjugates

Chemically reactive carbocyanine dyes incorporating an indolium ring moiety that is substituted at the 3-position by a reactive group or by a conjugated substance, and their uses, are described. Conjugation through this position results in spectral properties that are uniformly superior to those of conjugates of spectrally similar dyes wherein attachment is at a different position. The invention includes derivative compounds having one or more benzo nitrogens.

Modified carbocyanine dyes and their conjugates

Chemically reactive carbocyanine dyes incorporating an indolium ring moiety that is substituted at the 3-position by a reactive group or by a conjugated substance, and their uses, are described. Conjugation through this position results in spectral properties that are uniformly superior to those of conjugates of spectrally similar dyes wherein attachment is at a different position. The invention includes derivative compounds having one or more benzo nitrogens.

Dye and coloring photosensitive composition

The present invention provides a dye that is excellent in solubility and excellent in heat resistance and a novel compound that is preferable for the dye, and specifically provides a yellow dye having a wavelength of maximum absorption in the region of 400 to 450 nm, and also provides a coloring (alkali-developable) photosensitive composition using the above-mentioned dye, and an optical filter using the above-mentioned coloring (alkali-developable) photosensitive composition, specifically a color filter that does not decrease luminance and thus is preferable for image display devices such as liquid crystal display panels. Specifically, a compound represented by the following general formula (1) is used as the dye. The content of the above-mentioned general formula (1) is as described in the description.

New quinolinium dyes and borates in photopolymerizable compositions

Dye compounds of the formula (see fig.1) (I),wherein X is for example CH, C-CH3 or +NOR L; R is inter alia C1-C6alkyl; R1 is for example C1-C8alkoxy or C1-C12alkyl; s is 0 to 4; R2 is for example hydrogen; Ar is for example a group , . (E); Y inter alia is C1-C6alkyl or C1-C6alkoxy; r in the formula (A) is 0 to 5, in the formulae (B) and (E) is 0 to 9 and in the formula (D) is 0 to 7; and L is an anion; in combination with an electron donor compound, especially a borate compound, are suitable as photoinitiators for the photopolymerization of radically polymerizable compositions.

次甲基类染料及其用途

本发明的课题是，提供能够吸收紫外至红外区域的光、耐光性和在溶剂中的溶解性优良、而且兼有适于其所应用的用途的热特性的新型的有机化合物及其用途。通过提供具有由2个假吲哚环各自借助假吲哚环上3位的碳原子通过2价连接基键合而成的双假吲哚骨架的假吲哚化合物以及次甲基类染料、以及含有该次甲基类染料的光记录介质来解决上述课题。

交联型花青化合物和使用了该化合物的光学记录材料

本发明提供一种下述通式(I)表示的花青化合物，其中，R 1 和R 2 各自独立地表示氢原子、羟基、卤原子、硝基、氰基、碳原子数为1～30的有机基团或通式(II)、通式(II')或通式(III)表示的基团，R 3 和R 4 各自独立地表示氢原子、碳原子数为1～30的有机基团或通式(III)表示的取代基，R 1 和R 2 也可以相互连接形成环结构，R 3 和R 4 也可以相互连接形成杂环，N－R 3 可以和邻接的聚甲炔链中的亚甲基相互连接形成杂环。X表示氧原子、硫原子、硒原子、－CR 5 R 6 －、－NH－或－NY j －，R 5 和R 6 各自独立地表示碳原子数为1～30的有机基团或通式(II)、通式(II')或通式(III)表示的取代基，R 5 和R 6 也可以相互连接形成环结构，Y j 表示碳原子数为1～30的有机基团或通式(III)表示的基团。Z 0 是碳原子数为1～10的有机基团，n是1或2，r是2～8，An q－ 表示q价的阴离子，q是1或2，p表示保持电荷为中性的系数。

Method for incorporating nitrogen containing methine light absorbers in pet and compositions thereof

Photoelectric conversion element, photoelectrochemical cell, and metal complex pigment used in same

전성 지지체 상측에, 색소가 흡착된 반도체 미립자의 층을 갖는 감광체층과, 전하 이동체층과, 대극을 배치 형성한 적층 구조를 가지는 광전 변환 소자로서, 그 색소가 하기 식 (1) 로 나타내는 금속 착물 색소인 광전 변환 소자. M 1 L 1 L 2 Z 1 (1) [식 (1) 에 있어서, M 1 은 금속 원자를 나타내고, Z 1 은 1 자리의 배위자를 나타낸다. L 1 은 특정한 3 자리의 배위자를 나타낸다. L 2 는, 특정한 2 자리의 배위자를 나타낸다.］ 1. A photoelectric conversion element having a laminate structure in which a counter electrode is disposed by arranging a photoconductor layer having a layer of semiconductor fine particles adsorbed thereon, a charge carrier layer and a counter electrode on the top of a conductive support, the dye having a metal complex represented by the following formula Photoelectric conversion element which is a dye. M One L One L 2 Z One (1) [In the formula (1), M One  Represents a metal atom, and Z One  Represents a 1-position ligand. L One  Represents a specific 3-position ligand. L 2 Represents a specific two-digit ligand.]

Novel organic dye and preparation thereof

본 발명은 신규한 유기염료 및 이의 제조방법에 관한 것으로, 본 발명의 염료 화합물은 염료감응태양전지(dye-sensitized solar cell, DSSC)에 사용되어 종래의 염료보다 향상된 몰흡광계수, J sc (단회로 광전류 밀도) 및 광전기 변환효율을 나타내어 태양전지의 효율을 크게 향상시킬 수 있고, 고가의 칼럼을 사용하지 않고도 정제가 가능하여 염료 합성단가를 획기적으로 낮출 수 있다. The present invention relates to a novel organic dye and a method for producing the same, the dye compound of the present invention is used in dye-sensitized solar cells (DSSC), improved molar absorption coefficient, J sc (single) than conventional dyes Low photocurrent density) and photovoltaic conversion efficiency can greatly improve the efficiency of the solar cell, and can be purified without using an expensive column, thereby significantly lowering the dye synthesis cost. 태양전지, 염료감응, 염료, 광전변환소자 Solar cell, dye-sensitized, dye, photoelectric conversion element

Colored curable composition for color filter, color filter, and production method thereof

The present invention relates to a color filter coloring solidifying composition, a color filter and the making method thereof. The solidifying composition has the advantages of solidifying with high sensitivity, excellent pattern forming property, restrained developing residua and excellent adhesivenss to the supporting body. The color filter has the coloring pattern which is formed by the solidifying composition of the invention and has high color reproducibility and has excellent shape. The making method can make the color filter with a high production efficiency. The color filter coloringsolidifying composition of the invention is characterized in that the composition includes the following components: (a) a compound with at least one ethylenically unsaturated double bond, (b) a photopolymerization initiating agent and (c) a colorant, wherein (b) the photopolymeriztion initiating agent includes the following component: (A) a biimidazole compound, (B) a sensibilization color element and (C) a mercapto-compound, the content of (A)+(B)+(C) is 5% to 15% calculated with wt% relative to the total solid component of the color filter coloring solidifying composition.

Optical Filter and Imaging Device

광학 필터는 디클로로메탄 내에서의 흡수 특성이 하기 요건을 충족시키는 근적외선 흡수 색소를 함유하는 흡수층을 구비한다. ·파장 400 내지 800㎚의 흡수 스펙트럼에 있어서, 670 내지 730㎚로 최대 흡수 파장λ max 를 갖는다. ·파장 430 내지 550㎚의 광에 있어서의 최대 흡광 계수ε A 와, 파장 670 내지 730㎚의 광에 있어서의 최대 흡광 계수ε B 사이에, 다음 관계식:ε B /ε A ≥65가 성립한다. ·분광 투과율 곡선에 있어서, 최대 흡수 파장λ max 에 있어서의 투과율을 10%라 했을 때의 최대 흡수 파장보다 단파장측에서 투과율이 80%가 되는 파장λ 80 과, 최대 흡수 파장λ max 의 차가 65㎚ 이하이다. The optical filter has an absorption layer containing a near infrared absorbing dye whose absorption characteristic in dichloromethane satisfies the following requirements. Has an absorption maximum wavelength? Max of 670 to 730 nm in an absorption spectrum of a wavelength of 400 to 800 nm. ? B /? A ? 65 between the maximum extinction coefficient? A in the light having a wavelength of 430 to 550 nm and the maximum extinction coefficient? B in the light having a wavelength of 670 to 730 nm. , According to the spectral transmittance curve, the difference between the maximum absorption wavelength λ max transmittance of 10% LA and the maximum wavelength λ 80 is the transmittance in the short wavelength side of the absorption wavelength is 80%, the maximum absorption wavelength λ max when in 65㎚ Or less.

Photoelectric conversion element, dye-sensitized solar cell, metal complex dye, dye solution, dye-adsorbing electrode, and method for producing dye-sensitized solar battery

光电转换元件、染料敏化太阳能电池、金属络合物色素、色素溶液及三联吡啶或其酯化物

一种光电转换元件及染料敏化太阳能电池、以及用于这些的金属络合物色素、色素溶液及三联吡啶化合物或其酯化合物，所述光电转换元件具有：导电性支撑体、包含电解质的感光体层、包含电解质的电荷转移体层、及对电极，感光体层具有承载有由特定式(1)表示的金属络合物色素的半导体微粒。

二氟代苯并三唑基太阳能电池材料及其制备方法和应用

本发明属于太阳能电池领域，其公开了一种二氟代苯并三唑基太阳能电池材料及其制备方法和应用；该太阳能电池材料具有下述结构式(I)： 式(I)中，R 1 、R 2 均为C 1 ～C 20 的烷基，n为10～50的整数。本发明提供的二氟代苯并三唑基太阳能电池材料，由于1,2,3-苯并三唑太阳能电池材料含有两个氟原子，其HOMO能级将降低0.11eV，而氟取代的1,2,3-苯并三唑又有两个强吸电子的亚胺基，氟取代的1,2,3-苯并三唑是一个有强吸电子性能的杂环化合物，且苯并三唑的N-H键的N上容易引入烷基链，该烷基链官能性基团可以提高太阳能的能量转换效率，从而解决太阳能电池材料太阳能电池低效率问题。