28-03-2013 дата публикации
Номер: US20130078255A1
Принадлежит:
The application is based on the surprising finding that proteins regulated by increased c-myc activity in the liver can be used as sis and/or treatment monitoring of cancer and dysplasia, in particular of liver cell dysplasia and hepatocellular carcinoma (HCC), and wherein the proteins are selected from a first group consisting of Polymeric immunoglobulin receptor, Phosphatidylinositol—glycan—specific phospholipase D, Alpha—fetoprotein, Antithrombin 3, Apolipoprotein E, Apolipoprotein M, Fibrinogen beta-chain, Haptoglobin, Paraoxonase 1, Retinol binding protein, Serum amyloid P- component, Transthyretin, or from a second group consisting of Afamin, Glutathione peroxidase 3, Hemopexin, Major urinary protein, Serine protease inhibitor A3K. Consequently, medical uses of said proteins, of corresponding compositions, of corresponding antibodies, of corresponding siRNA and of corresponding nucleotide sequences are claimed. Also claimed are corresponding kits and corresponding methods and procedures. 1. A Protein regulated by increased c-myc activity in the liver for use as a biomarker in the diagnosis , prognosis and/or monitoring the treatment of liver cell dysplasia (premalignant stage) or hepatocellular carcinoma (HCC) , wherein the protein is selected from a first group consisting of Polymeric immunoglobulin receptor , Phosphatidylinositol-glycan-specific phospholipase D , Alpha-fetoprotein , Antithrombin 3 , Apolipoprotein E , Apolipoprotein M , Fibrinogen beta-chain , Haptoglobin , Paraoxonase 1 , Retinol binding protein , Serum amyloid P-component , and Transthyretin , or from a second group consisting of Afamin , Glutathione peroxidase 3 , Hemopexin , Major urinary protein , and Serine protease inhibitor A3K.2. The Protein according to for use as biomarker in the diagnosis claim 1 , prognosis and/or treatment monitoring of dysplasia or cancer claim 1 , colon claim 1 , lung and stomach dysplasia or cancer wherein the protein is selected from a first group ...
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