29-04-2021 дата публикации
Номер: US20210123163A1
Принадлежит:
The invention relates to non-woven protein fibers and to methods for forming and producing the same. In certain embodiments, the invention provides a method of processing a protein comprising dissolving a protein in a solution, optionally removing any insoluble materials from the solution, and spraying the solution under an applied pressure. In other embodiments, the protein can be derived from a range of sources, including but not limited to arthropod silks, animal keratin (e.g. hair and wool), tissue elastin, collagen, resilin, and plant protein. In certain embodiments, the methods of the invention are an alternative to electrospinning methods known in the art. 1. A method of producing non-woven protein fibers , the method comprising:(a) dissolving a protein in an acidic solution;(b) optionally removing any insoluble material from the solution; and wherein the solution is sprayed without application of an electrical potential; and', 'wherein at least one additional non-protein material is present in the acidic solution and is selected from the group consisting of a pharmaceutical agent, synthetic polymer, natural polymer, plasticizer, metal, metal alloy, metal oxide, metal salt, ceramic, glass, natural composite, synthetic composite, carbon material, nanoparticle, nanotube, nanofiber, nanosheet, microsphere, microfiber, and any combinations thereof., '(c) spraying the solution under an applied pressure at a collection surface, such that the solution evaporates after being sprayed, forming protein fibers upon reaching or before reaching the collection surface;'}2. The method of claim 1 , wherein the at least one additional non-protein material is at least one of the following:{'sub': 2', '2', '2', '3', '2', '3, '(a) a metal oxide selected from the group consisting of SiO, TiO, CaO, AlO, CuO, ZnO, FeO, MnO, NiO, BaO, SrO, and FeO;'}(b) a pharmaceutical agent selected from the group consisting of an antibiotic, a β-lactamase inhibitor, an anti-diabetic agent, and an ...
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