15-11-2018 дата публикации
Номер: US20180325834A1
Принадлежит:
DERMTREAT APS
The present invention relates to electrospun fibers comprising 16-. (canceled)7. Electrospun fibers comprising(i) a hydrophilic polymer that is soluble in a first solvent, wherein the hydrophilic polymer comprises one or more selected from polyvinylpyrrolidone (PVP), ethylcellulose, hydroxypropylcellulose, acrylates, polymers of acrylic/methacrylic esters, and mixtures thereof;(ii) a bioadhesive substance that has a solubility in said first solvent of 0.5 g/100 ml or less at 25° C., wherein the bioadhesive substance comprises one or more selected from dextrans, polyethylene oxides (PEOs), alginate, tragacanth, carrageenan, pectin, guar, xanthan, gellan, methylcellulose, hydroxypropylmethylcellulose (HPMC), polyvinylalcohol (PVA), polymers of acrylic acids (PAAs), chitosan, lectins, thiolated polymers, nonionic water-soluble polyethylene oxide resins (polyox WSR), and PAA polyethylene glycol copolymers (PAA-co-PEG), and mixtures thereof; and(iii) one or more corticosteroids.8. Electrospun fibers according to claim 7 , wherein at least a portion of the bioadhesive substance is attached to the fibers as particles in an undissolved form claim 7 , wherein the portion of the bioadhesive substance attached to the fibers in an undissolved form is not an integral part of the fibers.9. Electrospun fibers according to claim 7 , wherein the corticosteroid is selected from amcinonide claim 7 , betamethasone claim 7 , budenoside claim 7 , clobetasol claim 7 , clobetasone claim 7 , cortisone claim 7 , desonide claim 7 , desoxycortisone claim 7 , desoximethasone claim 7 , dexamethasone claim 7 , diflucortolon claim 7 , diflorasone claim 7 , flucortisone claim 7 , flumethasone claim 7 , flunisolide claim 7 , fluocinonide claim 7 , fluocinolon claim 7 , fluorometholone claim 7 , fluprednisolone claim 7 , flurandrenolide claim 7 , fluticasone claim 7 , halcinonide claim 7 , halobetasol claim 7 , hydrocortisone claim 7 , meprednisone claim 7 , methylprednisone claim 7 , mometasone ...
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