11-10-2018 дата публикации
Номер: US20180291773A1
Принадлежит:
The present invention relates to a process for preparing Lomitapide or its pharmaceutically acceptable salt thereof having high purity with acceptable levels of impurities. 110-. (canceled)12. The process as claimed in claim 11 , wherein solvent used in step i) selected from the group comprising of methanol claim 11 , ethanol claim 11 , isopropanol claim 11 , methylene chloride claim 11 , dimethyl formamide claim 11 , ethyl acetate claim 11 , isopropyl acetate claim 11 , acetonitrile claim 11 , heptane claim 11 , toluene claim 11 , n-heptane claim 11 , n-hexane claim 11 , diisopropyl ether claim 11 , tetrahydrofuran claim 11 , 1 claim 11 ,4-dioxane or mixture thereof.13. The process as claimed in claim 11 , wherein debenzylation in step iv) carried out using a metal catalyst is selected from the group comprising of palladium and platinum.14. The process as claimed in claim 11 , wherein acid used in step iv) selected from the group comprising of hydrochloric acid claim 11 , hydrobromic acid claim 11 , acetic acid and formic acid.15. The process as claimed in claim 11 , wherein acid salt of compound of Formula III is selected from the group comprising of hydrochloric acid salt claim 11 , hydrobromic acid salt claim 11 , acetic acid salt and formic acid salt.1617-. (canceled)18. The process as claimed in claim 11 , wherein solvent used in step i) selected from the group comprising of methanol claim 11 , ethanol claim 11 , methylene chloride claim 11 , acetonitrile claim 11 , acetone claim 11 , ethylacetate claim 11 , dimethyl formamide or mixture thereof.19. The process as claimed in claim 11 , wherein solvent used in step ii) selected from the group comprising of methanol claim 11 , ethanol claim 11 , methylene chloride claim 11 , acetonitrile claim 11 , acetone claim 11 , ethyl acetate claim 11 , n-heptane claim 11 , n-hexane claim 11 , toluene claim 11 , dimethyl formamide or mixture thereof.20. The process as claimed in claim 11 , wherein acid used in step iii) ...
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