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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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Поддерживает ввод нескольких поисковых фраз (по одной на строку). При поиске обеспечивает поддержку морфологии русского и английского языка
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Применить Всего найдено 2354. Отображено 100.
19-01-2012 дата публикации

Microfluidic system including a bubble valve for regulating fluid flow through a microchannel

Номер: US20120015442A1
Автор: John Richard Gilbert, Manish Deshpande, Sebastian Böhm
Принадлежит: Cytonome ST LLC

A microfluidic system includes a bubble valve for regulating fluid flow through a microchannel. The bubble valve includes a fluid meniscus interfacing the microchannel interior and an actuator for deflecting the membrane into the microchannel interior to regulate fluid flow. The actuator generates a gas bubble in a liquid in the microchannel when a sufficient pressure is generated on the membrane.

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Номер записи: 1
29-03-2012 дата публикации

Thermal Microvalves

Номер: US20120077231A1
Автор: Brian N. Johnson, Mark A. Burns, Michael Chen
Принадлежит: University of Michigan

The movement and mixing of microdroplets through microchannels is described employing silicon-based microscale devices, comprising microdroplet transport channels, reaction regions, electrophoresis modules, and radiation detectors. The discrete droplets are differentially heated and propelled through etched channels. Electronic components are fabricated on the same substrate material, allowing sensors and controlling circuitry to be incorporated in the same device.

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Номер записи: 2
19-04-2012 дата публикации

Valve for lab-on-a-chip systems, method for actuating and for producing valve

Номер: US20120090692A1
Автор: Katja Friedrich, Peter Paulicka, Walter Gumbrecht
Принадлежит: SIEMENS AG

A substrate of a lab-on-a-chip system has two adjacent recesses, one serving as a flow channel and the other one being filled with an elastomer compound. In a first state, the elastomer compound and the substrate delimit the flow channel in a section. In a second state, the elastomer compound takes up the space in the recess in the substrate along a cross-section of the flow channel, thereby completely closing the flow channel. The substrate and the elastomer compound may be produced by injection molding techniques.

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Номер записи: 3
07-06-2012 дата публикации

Valve

Номер: US20120138180A1
Автор: James Edward Mccrone, Justin Rorke Buckland, Stuart Andrew Hatfield
Принадлежит: Technology Partnership PLC

A valve for controlling the flow of fluid having first ( 16 ) and second ( 14 ) plates with offsetting apertures and a sidewall ( 12 ) disposed between the plates around the perimeter of the plates to form a cavity ( 15 ) in fluid communication with the apertures is disclosed. The valve further comprises a flap ( 17 ) disposed and moveable between the first and second plates and having apertures ( 22 ) substantially offset from the apertures ( 20 ) of one plate ( 16 ) and substantially aligned with the apertures ( 18 ) of the other plate ( 14 ). The flap is motivated between the two plates in response to a change in direction of the differential pressure of fluid across the valve.

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Номер записи: 4
14-06-2012 дата публикации

System and method for microfluidic flow control

Номер: US20120145253A1
Автор: Gregory A. Dale, Shulin Zeng
Принадлежит: Canon US Life Sciences Inc

A system and method for controlling fluid flow within a microchannel includes a fluid circuit comprising a fluid outlet well and one or more fluid inlet wells, all in communication with a microchannel. A negative pressure differential is applied to the outlet well and fluid flow from an inlet well into the microchannel is controlled by opening or closing the inlet well to atmospheric pressure. To stop fluid flow from the inlet well, a negative pressure differential may be applied to the inlet well to equalize pressure between the inlet and outlet wells. By sequentially opening and closing different inlet wells to atmosphere, controlled amounts of different reagents can be serially introduced into the microchannel.

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Номер записи: 5
19-07-2012 дата публикации

Selective bond reduction in microfluidic devices

Номер: US20120184046A1
Автор: Micah Atkin
Принадлежит: Individual

The invention overcomes the limitations described for the bonding of structured layers by providing a method for selectively reducing the bonding of materials. In its most generic form, the invention uses a bonding technique in combination with a printing method for modifying or covering at least one portion of a surface to either fully or partially prevent localised bonding. The structuring process may act upon the layers either before or after the bonding of the layers. The invention overcomes the limitations described in the application of affinity chromatography by providing a planar substrate with discrete optical detection flow cells that contain porous material and have connecting microchannels for fluid delivery and/or removal, and a method for making the same.

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Номер записи: 6
11-10-2012 дата публикации

Rack for sample tubes and reagent holders

Номер: US20120258463A1
Автор: Jeff Williams, Kalyan Handique, Kerry Wilson, Patrick Duffy
Принадлежит: HandyLab Inc

A rack for holding samples and various reagents, wherein the rack may be used for loading the samples and reagents prior to using the reagents. The rack accepts complementary reagent holders, each of which contain a set of reagents for carrying out a predetermined processing operation, such as preparing biological samples for amplifying and detecting polynucleotides extracted from the samples.

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Номер записи: 7
01-11-2012 дата публикации

Ferrofluid control and sample collection for microfluidic application

Номер: US20120275929A1
Автор: Kenneth Salsman
Принадлежит: Aptina Imaging Corp

A fluid conveyance system includes a flow passage and a cavity adjacent a side of the flow passage. A wall of the passage includes a flexible section that separates the cavity from the flow passage. The cavity contains a ferrofluidic material. The system further includes at least one magnetic field source positioned adjacent the flow channel. The magnetic field source is operable to move the ferrofluidic material in the cavity to exert a pressure on the flexible section and displace the flexible section into the flow passage to alter the flow of material through the passage. A method of collecting components from a sample volume includes the steps of distributing magnetic particles into the sample volume, capturing the components from the sample volume, and applying a magnetic field to the sample volume to control directional flow of the sample volume.

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Номер записи: 8
13-12-2012 дата публикации

Micromechanic passive flow regulator

Номер: US20120316492A1
Автор: Eric Chappel
Принадлежит: Debiotech SA

The invention concerns a flow regulator, made of a stack of 3 plates, respectively a top plate including a flexible membrane ( 1 ), a middle plate ( 2 ) with pillars and through holes and a bottom plate ( 3 ) with fluidic ports, micro channels and through holes ( 8,9,12 ). The principle is based on the deformation of the membrane due to the pressure of the liquid. The membrane goes in contact with the pillars of the middle plate, obstructing gradually the through holes of the pillars. The device is designed to keep the flow constant in a predefined range of pressure. The device is dedicated to ultra low flow rate up to 1 ml per day or below, typically for drug infusion. Plastic flow regulators comprise preferably several independent valves coupled in parallel. The membrane plate is therefore made of several flexible membranes obstructing gradually the flow by increasing the pressure. Stress limiters are used to avoid plastic deformation of the membrane. For implanted pump, the use of a flow regulator instead of a flow restrictor has several advantages, including the possibility to reduce significantly the reservoir pressure and to generate directly the pressure during the pump filling by using an elastic drug reservoir.

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Номер записи: 9
27-12-2012 дата публикации

Microfabricated elastomeric valve and pump systems

Номер: US20120328834A1
Автор: Axel Scherer, Hou-Pu Chou, Marc A. Unger, Stephen R. Quake, Todd A. Thorsen
Принадлежит: California Institute of Technology CalTech

A method of fabricating an elastomeric structure, comprising: forming a first elastomeric layer on top of a first micromachined mold, the first micromachined mold having a first raised protrusion which forms a first recess extending along a bottom surface of the first elastomeric layer; forming a second elastomeric layer on top of a second micromachined mold, the second micromachined mold having a second raised protrusion which forms a second recess extending along a bottom surface of the second elastomeric layer; bonding the bottom surface of the second elastomeric layer onto a top surface of the first elastomeric layer such that a control channel forms in the second recess between the first and second elastomeric layers; and positioning the first elastomeric layer on top of a planar substrate such that a flow channel forms in the first recess between the first elastomeric layer and the planar substrate.

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Номер записи: 10
14-02-2013 дата публикации

Micro-Fluidic System

Номер: US20130037139A1
Автор: Alex Calanca, Gianni Medoro, Nicolò Manaresi
Принадлежит: Silicon Biosystems SpA

A micro-fluidic system comprising a micro-fluidic channel, which has a wall provided with a hole; a closing element, which is partially housed within the hole and has a membrane portion adapted to deform and a side portion sealingly connected with the above mentioned wall; and a partition arranged within the micro-fluidic channel between a first and a second segment; the closing element is deformable between a locked configuration in contact with the partition and an open configuration spaced from the partition; the closing element may be deformed by suction or by a rod or a piston.

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Номер записи: 11
16-05-2013 дата публикации

Microfluidic device with deformable valve

Номер: US20130121893A1
Автор: Emmanuel Delamarche, Laetitia C. Avrain, Martina Hitzbleck, Pascal Y. Mertens, Thierry C. Laurent, Valérie SMEKENS
Принадлежит: Coris Bioconcept SPRL, International Business Machines Corp

A microfluidic device includes a first microchannel, a second microchannel, and a valve comprising at least an input port and an output port, the ports respectively connected to the first microchannel and the second microchannel, the valve designed to control a flow of a liquid along a flow direction (z) defined by the ports; wherein the valve further comprises one or more walls joining the ports and defining a hollow chamber that is wider than each of the microchannels in a direction perpendicular to the flow direction, the walls at least partly deformable along a deformation direction (−y) intersecting the flow direction, such that the walls can be given at least a first deformation state and a second deformation state, such that the liquid can be pulled along the flow direction substantially more in the second deformation state than in the first deformation state.

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Номер записи: 12
23-05-2013 дата публикации

Microfluidic platform for discrete cell assay

Номер: US20130130301A1
Автор: Euisik Yoon, Kim Young-Ji
Принадлежит: University of Michigan

A microfluidic chamber for use in individual cell assays. The microfluidic chamber includes a cell microchamber having an interior region and front and rear valves, each of which are separately controllable so that they can be selectively opened and closed to thereby permit the transference of an individual cell into and out of the interior region. Cell secretion and contact interaction studies can be carried out using the microchambers, with the valves permitting either complete isolation or perfusion media flow through the microchambers. An internal perfusion wall can be included to partition the microchamber for non-contact perfusion studies of secretion interactions between cells.

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Номер записи: 13
06-06-2013 дата публикации

Microfluidic devices with mechanically-sealed diaphragm valves

Номер: US20130139895A1
Автор: Mattias Vangbo
Принадлежит: Integenx Inc

This invention provides a fluidic device comprising a diaphragm valve having a fluidics layer, an actuation layer and an elastic layer between the fluidics layer and the actuation layer, the elastic layer having a diaphragm that is mechanically sealed against the fluidics layer and the actuation layer by a sealing ring in the actuation layer.

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Номер записи: 14
15-08-2013 дата публикации

Microfluidic chips and assay systems

Номер: US20130209327A1
Автор: Lincoln C. Young, Peng Zhou
Принадлежит: Rheonix Inc

The systems and methods described herein include a microfluidic chip having a plurality of microfeatures interconnected to provide a configurable fluid transport system for processing at least one reagent. Inserts are provided to removably interfit into one or more of the microfeatures of the chip, wherein the inserts include sites for interactions with the reagent. As will be seen from the following description, the microfluidic chip and the inserts provide an efficient and accurate approach for conducting parallel assays.

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Номер записи: 15
15-08-2013 дата публикации

Microfluidic chip comprising several cylinder-piston arrangements

Номер: US20130209328A1
Автор: Daniel Latta, Klaus-Stefan Dresse, Marion Ritzi-Lehnert, Tina Roeser
Принадлежит: INSTITUT FUER MIKROTECHNIK MAINZ GMBH

A microfluidic arrangement including a substrate in which a mircofluidic structure having several adjacent channels and at least one common supply line, into which the adjacent channels merge, is formed. Each of the adjacent channels form the cylinder of a cylinder-piston arrangement for receiving an associated piston. A method for producing the type of microfluidic-arrangement is also disclosed.

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Номер записи: 16
03-04-2014 дата публикации

Valved, Microwell Cell-Culture Device And Method

Номер: US20140090735A1
Автор: Paul Ju-Sung Hung, Philip Janmin Lee
Принадлежит: EMD Millipore Corp

A valved microfluidics device, microfluidics cell-culture device and system incorporating the devices are disclosed. The valved microfluidics device includes a substrate, a microchannel through which liquid can be moved from one station to another within the device, and a pneumatic microvalve adapted to be switched between open and closed states to control the flow of fluid through a microchannel. The microvalve is formed of three flexible membranes, one of which is responsive to pneumatic pressure applied to the valve and the other two of which deform to produce a more sealable channel cross-section. The cell culture device provides valving to allow controlled loading of cells into the individual well of the device, and exchange of cell-culture components in the wells.

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Номер записи: 17
07-01-2021 дата публикации

MICROFLUIDIC VALVE AND METHOD OF MAKING SAME

Номер: US20210001334A1
Автор: Haley Cecelia, Handique Kalyan, Parunak Gene
Принадлежит:

The present technology provides for a microfluidic substrate configured to carry out PCR on a number of polynucleotide-containing samples in parallel. The substrate can be a single-layer substrate in a microfluidic cartridge. Also provided are a method of making a microfluidic cartridge comprising such a substrate. Still further disclosed are a microfluidic valve suitable for use in isolating a PCR chamber in a microfluidic substrate, and a method of making such a valve. 118.-. (canceled)19. A method of making a microfluidic valve , the method comprising:directing a dispensing head over an inlet hole in a microfluidic substrate;propelling a quantity of thermally responsive substance from the dispensing head into the inlet hole;maintaining a temperature of the microfluidic substrate so that the thermally responsive substance flows by capillary action into a microfluidic channel in communication with the inlet hole; andcovering the inlet hole.20. The method of claim 19 , wherein covering the inlet hole comprises covering two or more inlet holes.21. The method of claim 19 , wherein covering the inlet hole comprises covering two or more inlet holes for valves that are in a sample lane of the microfluidic substrate.22. The method of claim 19 , wherein covering the inlet hole comprises covering two or more inlet holes for valves that are in different sample lanes of the microfluidic substrate.23. The method of claim 19 , wherein covering the inlet hole comprises covering the microfluidic substrate with a layer of plastic.24. The method of claim 19 , wherein covering the inlet hole comprises covering the microfluidic substrate with a layer comprising a pressure sensitive adhesive.25. The method of claim 19 , wherein propelling a quantity of thermally responsive substance comprises propelling a quantity of thermally responsive substance to the bottom of the inlet hole.26. The method of claim 19 , wherein propelling a quantity of thermally responsive substance comprises ...

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Номер записи: 18
05-01-2017 дата публикации

MICROFABRICATED ELASTOMERIC VALVE AND PUMP SYSTEMS

Номер: US20170001195A1
Автор: Adams Mark L., Chou Hou-Pu, Enzelberger Markus, Hansen Carl L., Quake Stephen R., Scherer Axel, Thorsen Todd A., Unger Marc Alexander
Принадлежит:

A method of fabricating an elastomeric structure, comprising: forming a first elastomeric layer on top of a first micromachined mold, the first micromachined mold having a first raised protrusion which forms a first recess extending along a bottom surface of the first elastomeric layer; forming a second elastomeric layer on top of a second micromachined mold, the second micromachined mold having a second raised protrusion which forms a second recess extending along a bottom surface of the second elastomeric layer; bonding the bottom surface of the second elastomeric layer onto a top surface of the first elastomeric layer such that a control channel forms in the second recess between the first and second elastomeric layers; and positioning the first elastomeric layer on top of a planar substrate such that a flow channel forms in the first recess between the first elastomeric layer and the planar substrate. 1. (canceled)2. The method of using a microfluidic device , comprising:flowing a sample into a looped channel of the microfluidic device;pumping the sample around the loop channel with a peristaltic action, wherein the peristaltic action comprises sequential activation of a series of individually addressable valves arranged along the looped channel.3. The method of claim 2 , wherein the series of individually addressable valves comprise three valves.4. The method of claim 3 , wherein each of the three valves is an intersection of an individually addressable control line over the looped channel.5. The method of claim 2 , wherein the microfluidic device is an elastomeric device.6. The method of claim 2 , wherein the pumping passes the sample over a DNA array. This nonprovisional patent application is a continuation of U.S. application Ser. No. 14/188,664 filed Feb. 24, 2014, which is a continuation of Ser. No. 11/932,263 filed Oct. 31, 2007, now U.S. Pat. No. 8,656,958, which is a continuation of U.S. application Ser. No. 11/685,654 filed Mar. 13, 2007, now U.S. Pat. ...

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Номер записи: 19
05-01-2017 дата публикации

ELECTRONIC DEVICE, WEARABLE DEVICE, PRESSURE REGULATOR VALVE AND METHOD FOR MANUFACTURING PRESSURE REGULATOR VALVE

Номер: US20170002939A1
Автор: KATSUDA Hiroshi, NISHIYAMA Hiroki, OHMURA Akihisa, Suzuki Akira
Принадлежит: CASIO COMPUTER CO., LTD.

An electronic device includes a housing and an internal pressure regulator valve. The internal pressure regulator valve includes a valve body of flexible material. The valve body has a valve hole and a hollow. The hollow is continuous with the valve hole and opens into the housing. Through the valve hole, gas is released to outside. 1. An electronic device comprising:a housing; andan internal pressure regulator valve including a valve body of flexible material having: a valve hole through which gas is released to outside; and a hollow which is continuous with the valve hole and opens into the housing.2. The electronic device according to claim 1 , wherein the valve body further has a projection which projects to the outside claim 1 , containing the valve hole.3. The electronic device according to claim 1 , wherein the internal pressure regulator valve opens claim 1 , thereby releasing the gas in the housing to the outside claim 1 , when an internal pressure of the housing is higher than an external pressure.4. The electronic device according to claim 3 , wherein the internal pressure regulator valve opens claim 3 , thereby releasing the gas in the housing to the outside claim 3 , when (i) the internal pressure is higher than the external pressure and (ii) a difference between the internal pressure and the external pressure is equal to or larger than a first predetermined difference.5. The electronic device according to claim 1 , wherein the internal pressure regulator valve closes claim 1 , thereby blocking liquid from entering the housing from the outside claim 1 , when an internal pressure of the housing is lower than an external pressure.6. The electronic device according to claim 5 , wherein the internal pressure regulator valve closes claim 5 , thereby blocking the liquid from entering the housing claim 5 , when (i) the internal pressure is lower than the external pressure and (ii) a difference between the internal pressure and the external pressure is equal to ...

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Номер записи: 20
04-01-2018 дата публикации

Device Having a Plurality of Latching Micro-Actuators and Method of Operating the Same

Номер: US20180003319A1
Автор: Besse Nadine, Rosset Samuel, Shea Herbert, Zarate Juan José
Принадлежит:

An actuator device including a plurality of transducer actuators, and a common pneumatic actuation mechanism for shaping the plurality of transducer actuators, wherein each actuator of the plurality of transducer actuators includes a shape memory polymer membrane, an integrated stretchable heater, and a pressure interface to the common pneumatic actuation mechanism. 1. An actuator device comprising:a plurality of transducer actuators; anda common pneumatic actuation mechanism for shaping the plurality of transducer actuators,wherein each actuator of the plurality of transducer actuators includes,a shape memory polymer membrane,an integrated stretchable heater, andan pressure interface to the common pneumatic actuation mechanism.2. The actuator device according to claim 1 , further comprising:a power control device to control electric power supplied to the integrated stretchable heater of each actuator of the plurality of transducer actuators, to selectively activate the transducer actuators individually.3. The actuator device according to claim 1 , wherein the common pneumatic actuation mechanism comprises:a pump that is configured to generate a positive and a negative pressure; anda pneumatic chamber having a common inlet that is arranged below the shape memory polymer membrane having a plurality of channels, each channel connected to a corresponding pressure interface of a corresponding actuator,wherein the pump is operatively connected to the common inlet of the pneumatic chamber.4. The actuator device according to claim 1 , wherein the pressure interface is made from an opening of a flexible printed circuit board.5. The actuator device according to claim 1 , wherein each shape memory polymer membrane is configured such that the common pneumatic actuation mechanism displaces only the actuators that are heated by the corresponding integrated stretchable heater.6. The actuator device according to claim 1 , further comprising:a microfluidic chip including ...

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Номер записи: 21
03-01-2019 дата публикации

SYSTEM AND METHOD FOR PROCESSING BIOLOGICAL SAMPLES

Номер: US20190002959A1
Автор: Kusner Michael T., Williams Jeffrey
Принадлежит:

A system and method for processing and detecting nucleic acids from a set of biological samples, comprising: a molecular diagnostic module configured to receive nucleic acids bound to magnetic beads, isolate nucleic acids, and analyze nucleic acids, comprising a cartridge receiving module, a heating/cooling subsystem and a magnet configured to facilitate isolation of nucleic acids, a valve actuation subsystem including an actuation substrate, and a set of pins interacting with the actuation substrate, and a spring plate configured to bias at least one pin in a configurations, the valve actuation subsystem configured to control fluid flow through a microfluidic cartridge for processing nucleic acids, and an optical subsystem for analysis of nucleic acids; and a fluid handling system configured to deliver samples and reagents to components of the system to facilitate molecular diagnostic protocols. 1. A system for processing a biological sample comprising:a cartridge platform receiving a cartridge including a fluidic pathway, wherein the cartridge platform comprises an access region configured to align with the fluidic pathway; a pin comprising a first end, a second end opposing the first end, and a pin slot defined along a length of the pin between the first and the second end, the pin actuatable along a displacement axis extending through the first end, the second end, and the access region; and', 'an actuation substrate translatable along an actuation axis between a first substrate position, wherein a first substrate feature of the actuation substrate passes through the pin slot to transmit the pin through the access region; and a second substrate position, wherein a second substrate feature of the actuation substrate passes through the pin slot to transmit the pin away from the access region., 'a valve actuation subsystem comprising2. The system of claim 1 , wherein the valve actuation system further comprises a spring coupled to a region of the pin claim 1 , ...

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Номер записи: 22
14-01-2016 дата публикации

Methods and Systems for Enhanced Microfluidic Processing

Номер: US20160008811A1
Автор: Amy Droitcour, Daniel Laser, Hailemariam NEGUSSIE, William BEHNKE-PARKS
Принадлежит: WAVE 80 BIOSCIENCES Inc

Methods and systems are provided for a microfluidic cartridge including a high performance actuator useful for analyte detection, labeling and analysis. Microfluidic processing systems are to carry out chemical or biochemical reactions, or sequences of reactions, with small volumes (typically between 1 microliter and 10 milliliters) of reactants and products. A microfluidic processing system can comprise a network of tubes interfaced with discrete components such as valves and sensors, or an integrated device made of plastic, glass, metal, or other materials, or a combination of materials, with components such as valves and sensors built into the device and connected by flow passageways formed in the material.

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Номер записи: 23
08-01-2015 дата публикации

Microfluidic Bubble Logic Devices

Номер: US20150011404A1
Автор: Manu Prakash, Neil Gershenfeld
Принадлежит: Massachusetts Institute of Technology

Fluid-based no-moving part logic devices are constructed from complex sequences of micro- and nanofluidic channels, on-demand bubble/droplet modulators and generators for programming the devices, and micro- and nanofluidic droplet/bubble memory elements for storage and retrieval of biological or chemical elements. The input sequence of bubbles/droplets encodes information, with the output being another sequence of bubbles/droplets or on-chip chemical synthesis. For performing a set of reactions/tasks or process control, the modulators can be used to program the device by producing a precisely timed sequence of bubbles/droplets, resulting in a cascade of logic operations within the micro- or nanofluidic channel sequence, utilizing the generated droplets/bubbles as a control. The devices are based on the principle of minimum energy interfaces formed between the two fluid phases enclosed inside precise channel geometries. Various devices, including logic gates, non-volatile bistable memory, ring oscillators, bubble synchronizers, analysis chips, sample collectors, and printers have been designed.

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Номер записи: 24
14-01-2016 дата публикации

Long-Throw Microfluidic Actuator

Номер: US20160010761A1
Автор: Droitcour Amy, Frey Jared, Laser Daniel, Negussie Hailemariam, Raduta Radu
Принадлежит:

A microfluidic device includes a three-dimensional slat structure having a plurality of interstices configured to generate a high power, high flow rate of fluids by electroosmotic flow. The microfluidic device includes a housing for holding and moving fluids through the slat structure, and a plurality of electrodes that generate an electric field within the plurality of interstices. 1. A device comprising:a slat structure comprising a rigid structural frame supporting a plurality of approximately evenly spaced slats, such slats having a thickness, and wherein said slat structure comprises a plurality of interstices between said slats and said plurality of interstices comprise a plurality of fluid passageways extending through said thickness such that a fluid is capable of flowing through said slat structure, wherein each of said plurality of interstices has an in-plane dimension a and a second in-plane dimension b, wherein said dimension a is between 1 and 10 microns and said dimension b is at least the lesser of fifty times greater than said dimension a of said interstice or 250 microns; and the number of interstices is at least ten; a first structure defining a first fluid cavity adapted for housing a fluid and in fluidic communication with a first side of said interstices;', 'a second structure defining a second fluid cavity adapted for housing a fluid and in fluidic communication with a second side of said interstices, wherein said first fluid cavity, said plurality of interstices in said slat structure, and said second fluid cavity define a fluid pathway, wherein a lowest flow resistance path from said first fluid cavity to said second fluid cavity is through said plurality of interstices; and, 'a housing enclosing said slat structure, comprisinga plurality of electrodes for generating an electric field within said plurality of interstices.2. The device of claim 1 , wherein said slat structure claim 1 , said housing claim 1 , and said plurality of electrodes ...

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Номер записи: 25
14-01-2021 дата публикации

MICROFLUIDIC SYSTEM FOR AMPLIFYING AND DETECTING POLYNUCLEOTIDES IN PARALLEL

Номер: US20210010059A1
Автор: Brahmasandra Sundaresh N., Ganesan Karthik, Handique Kalyan, Williams Jeff
Принадлежит:

The present technology provides for an apparatus for detecting polynucleotides in samples, particularly from biological samples. The technology more particularly relates to microfluidic systems that carry out PCR on nucleotides of interest within microfluidic channels, and detect those nucleotides. The apparatus includes a microfluidic cartridge that is configured to accept a plurality of samples, and which can carry out PCR on each sample individually, or a group of, or all of the plurality of samples simultaneously. 1. A method of carrying out amplification on a plurality of samples , the method comprising:introducing each of the plurality of samples into an amplification zone of a multi-lane microfluidic cartridge;isolating each of the plurality of samples within the multi-lane microfluidic cartridge;independently thermally cycling each amplification zone; andamplifying polynucleotides contained within each of the plurality of samples.2. The method of claim 1 , further comprising detecting the presence of a polynucleotide or a polynucleotide probe in the plurality of samples.3. The method of claim 1 , wherein independently thermally cycling each amplification zone comprises heating each amplification zone with a plurality of heaters.4. The method of claim 1 , wherein independently thermally cycling each amplification zone comprises heating each amplification zone with four heaters.5. The method of claim 1 , wherein independently thermally cycling each amplification zone comprises heating each amplification zone with two long heaters and two short heaters.6. The method of claim 1 , wherein isolating each of the plurality of samples comprises closing at least one valve.7. A method of carrying out amplification on a plurality of samples claim 1 , the method comprising:introducing a sample of a plurality of samples into an amplification zone in a lane of a multi-lane microfluidic cartridge;isolating the sample from the plurality of samples within the multi-lane ...

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Номер записи: 26
03-02-2022 дата публикации

System And Method For Valve Control

Номер: US20220032018A1
Автор: CHOWDHURY Shilpika, Henschel Mark E., Ruben David A., Sutanto Jemmy, Wasson James
Принадлежит:

Disclosed is a system including a flow control assembly. The system may include a flow regulating shunt system, for various purposes. The flow control assembly may be controlled according to selected parameters and methods. 1. A method of operating a flow and/or pressure regulating assembly for a hydrocephalus shunt system , the method comprising:biasing a valve member in a closed position relative to a valve seat with an arm support member;sensing a parameter relative to the valve member; andoperating an actuator formed from and on a substrate near the arm support member to be positioned in an active position or an inactive position relative to the arm support member to effect a biasing force applied to the valve member.2. The method of claim 1 , further comprising:selecting an effective support length of the arm support member to determine the biasing force on the valve member.3. The method of claim 2 , further comprising:executing instructions with a controller to compare a sensed pressure applied to an inlet side of the valve member to determine the position of the actuator.4. The method of claim 3 , wherein operating the actuator in the active position includes decreasing a support length of the arm support member to increase the biasing force.5. The method of claim 3 , wherein operating the actuator in the inactive position includes increasing or maximizing a support length of the arm support member to decrease the biasing force.6. The method of claim 1 , further comprising:selecting a set point for the parameter;comparing the set point of the parameter to the sensed parameter; andselecting a position of the actuator based on the comparison.7. The method of claim 6 , wherein the parameter is an inlet pressure.8. The method of claim 7 , further comprising:receiving the selected set point; andstoring the set point.9. The method of claim 7 , further comprising:executing instructions with a controller to perform the comparison;transmitting an actuation signal to ...

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Номер записи: 27
18-01-2018 дата публикации

INTEGRATED FLUIDIC MODULE

Номер: US20180015467A1
Автор: Liang Qian, Liu Yi-Shao, Utama Revata
Принадлежит:

An integrated fluidic module includes a fluid manifold, a valve stator, a valve rotor and a valve housing. The fluid manifold includes microchannels connected to a sample reaction unit, and fluid input channels connected to fluid sources. The valve stator includes at least one groove and plural through holes, at least one groove is connected with at least one of the plural through holes, and parts of the groove and through holes are communicated with the microchannels and the fluid input channels. The valve rotor includes at least one groove. The valve housing accommodates the valve rotor and the valve stator. When the valve rotor is rotated to different positions, at least one groove of the valve rotor is connected with at least one through hole or groove of the valve stator to provide at least one fluid path and enable fluids provided by the fluid sources to be directed to corresponding chambers of the sample reaction unit through the fluid path. 1. An integrated fluidic module connected with a sample reaction unit having multiple chambers to regulate fluid operations in a multi-fluid-system , the integrated fluidic module comprising:a fluid manifold comprising a main body, plural microchannels and plural fluid input channels, wherein each of the plural microchannels penetrates through the main body and is connected with a corresponding chamber of the sample reaction unit, and the plural fluid input channels are connected with plural fluid sources;a valve stator attached to the fluid manifold and comprising at least one groove and plural through holes, wherein the at least one groove of the valve stator is disposed on a top surface or a bottom surface of the valve stator and is directly connected with at least one of the plural through holes, and at least parts of the groove and the through holes are communicated with the plural microchannels and plural fluid input channels of the fluid manifold;a valve rotor attached to the valve stator and comprising at least ...

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Номер записи: 28
17-01-2019 дата публикации

METHOD AND APPARATUS FOR SORTING PARTICLES

Номер: US20190015841A1
Автор: Bohm Sebastian, Deshpande Manish, Gilbert John R.
Принадлежит:

A method and apparatus for sorting particles moving through a closed channel system of capillary size comprises a bubble valve for selectively generating a pressure pulse to separate a particle having a predetermined characteristic from a stream of particles. The particle sorting system may further include a buffer for absorbing the pressure pulse. The particle sorting system may include a plurality of closely coupled sorting modules which are combined to further increase the sorting rate. The particle sorting system may comprise a multi-stage sorting device for serially sorting streams of particles, in order to decrease the error rate. 1. A microfluidic system for sorting particles , the microfluidic system comprising:a first microfluidic flow channel formed in a particle processing component substrate having an upstream inlet configured to introduce a fluidic stream having a plurality of particles into the first microfluidic flow channel and downstream outlets configured to output portions of the fluidic stream of particles;a detection region located downstream of the inlet, the detection region configured to allow a particle having a predetermined characteristic to be sensed, the sensed particle being one of the plurality of particles in the fluidic stream; anda switching device located downstream of the detection region, the switching device operatively coupled to the first microfluidic flow channel to deliver a transient pressure pulse in a direction substantially perpendicular to a flow direction of the fluidic stream of particles,wherein the transient pressure pulse displaces and separates a selected single sensed particle from the fluidic stream of particles,wherein the selected particle is displaced and separated from the fluidic stream of particles in a switching region,wherein the fluidic stream of unselected particles flows into a first downstream outlet configured to output a first portion of the fluidic stream of particles,wherein the selected particle ...

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Номер записи: 29
18-01-2018 дата публикации

Sieve Valves, Microfluidic Circuits, Microfluidic Devices, Kits, and Methods for Isolating an Analyte

Номер: US20180016633A1
Автор: BLAINEY Paul, KIM SOOHONG
Принадлежит:

The invention generally provides a sieve valve including: a substrate defining a channel; a flexible membrane adapted and configured for deployment at an intersection with the channel; and one or more protrusions extending into the channel from the substrate or the flexible membrane. The one or more protrusions define a plurality of recesses extending beyond the intersection between the channel and the flexible membrane; 1. A method of isolating an analyte , the method comprising:loading a sample into a holding chamber of a microfluidic circuit, the microfluidic circuit including one or more sieve valves, wherein the holding chamber is in fluid communication with an input port of a mixing circuit,capturing an analyte on a capture substrate in the mixing circuit;washing the capture substrate to remove uncaptured components; and a substrate defining a channel;', 'a flexible membrane adapted and configured for deployment at an intersection with the channel; and', 'one or more protrusions extending into the channel from the substrate or the flexible membrane, the one or more protrusions defining a plurality of recesses extending beyond the intersection between the channel and the flexible membrane; and, 'releasing the analyte from the capture substrate, wherein the sieve valve comprises'}passing the sample into the mixing circuit.2. The method of claim 1 , wherein the capture substrate is loaded into the microfluidic circuit claim 1 , the holding chamber claim 1 , and/or the mixing circuit.3. The method of claim 1 , wherein the capture substrate comprises a bead claim 1 , microbead claim 1 , surface of the microfluidic circuit claim 1 , or a capture reagent.4. The method of claim 1 , wherein the mixing circuit comprises a plurality of chambers in fluid communication with one or more holding chambers claim 1 , wherein the one or more holding chambers and/or the mixing circuit comprises the capture substrate for isolating the analyte.5. The method of claim 4 , wherein the ...

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Номер записи: 30
21-01-2016 дата публикации

MICROFLUIDIC VALVE HAVING IMPROVED TOLERANCE TO PARTICLES

Номер: US20160018021A1
Автор: Chappel Eric
Принадлежит:

The present invention describes a valve for controlling the passage of a microfluidic system. Said valve comprises a first valve element () and a second valve element () with respective first and second contact surfaces which are placed opposite to each other in such a way as to control a fluid flow through said passage. Said first valve element comprising a flexible part and a rigid part. 2. The valve according to the claim 1 , wherein the flexible part is designed to bend in a direction perpendicular to a plan of the surface of the rigid part.3. The valve according to claim 1 , wherein the surface of the planar component and/or the surface of the second valve element has a Knoop hardness of at least 300 KHN.4. The valve according to claim 1 , wherein the surface of the planar component and/or the surface of the second valve element has a Knoop hardness of at least 500 KHN.5. The valve according to claim 1 , wherein the surface of the planar component and/or the surface of the second valve element has a Knoop hardness of at least 800 KHN.6. The valve according to claim 1 , wherein the surface of the planar component and/or the surface of the second valve element has a Knoop hardness of at least 1100 KHN.7. The valve according to the claim 1 , wherein the hardness factor of the flexible part is substantially equal to the hardness factor of the rigid part according to the Knoop hardness scale.8. The valve according to the claim 1 , wherein the hardness factor of the planar component is substantially equal to the hardness factor of the second valve element according to the Knoop hardness scale.9. The valve according to the claim 1 , wherein said first valve element further comprises a support which is fixed to the planar component.10. The valve according to claim 9 , wherein said rigid part is constituted by stacking of said support and said planar component.11. The valve according to claim 1 , wherein said second valve element comprises at least two parts:{'b': 1', ' ...

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Номер записи: 31
18-01-2018 дата публикации

INTEGRATED HEATER AND MAGNETIC SEPARATOR

Номер: US20180017184A1
Автор: Handique Kalyan
Принадлежит:

An apparatus for providing thermal and magnetic energy to a receptacle containing a reaction mixture and a magnetic retention member. The apparatus can also control heating of a reaction mixture, and bring about a separation of magnetic particles from the reaction mixture. The reaction mixture typically comprises polynucleotides from a biological sample that are being brought into a PCR-ready form. 128.-. (canceled)29. A method of extracting nucleic acids using a rack and an integrated separator and heater , the integrated separator and heater comprising a plurality of heater units aligned collinearly along a horizontal first axis , the integrated separator and heater further comprising one or more magnets disposed on a first side of the plurality of heater units and aligned along a second axis parallel to the first axis , the method comprising:inserting a plurality of holders in the rack, each holder comprising a single process tube of a plurality of process tubes;inserting the rack into the integrated separator and heater such that at least a portion of rack is removably received on a second side of the plurality of heater units opposite the one or more magnets on the first side, wherein a portion of each process tube of the plurality of process tubes is received in a single heater unit of the plurality of heater units when the rack is inserted into the integrated separator and heater;moving all of the one or more magnets backwards and forwards together in a vertical direction perpendicular to the second axis while maintaining proximity to an exterior side of each of the process tubes received in the integrated separator and heater;during at least a portion of the motion, moving magnetic particles contained in the process tubes; andindependently controlling each heater unit of the plurality of heater units to apply heat to the plurality of process tubes received in the integrated separator and heater.30. The method of claim 29 , wherein all of the one or more ...

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Номер записи: 32
17-04-2014 дата публикации

Fluidic interface valve assembly with elastomeric ferrule device

Номер: US20140102568A1
Автор: Carl M. Servin
Принадлежит: Idex Health and Science LLC

A tubing interface having an elongated tube, an elastomeric ferrule and a support ring device disposed around the ferrule. The ferrule includes a bore which is sized for receipt of the tube. The tubing interface further includes a cap member having an exterior surface, an opposed interior surface, and a tube receiving passage extending therethrough. The receiving passage is formed and dimensioned for axial sliding receipt of the tube member therethrough. The cap member further includes a cup-shaped receiving recess extending proximally from the interior surface, and is formed and dimensioned for axial receipt of the proximal end of the ferrule body member and the support ring. When the cap member is mounted to a valve apparatus, the support ring and the elastomeric ferrule device compressively cooperate with the cup-shaped recess to form a fluid-tight seal between the tube port and a communication port of the valve apparatus.

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Номер записи: 33
17-01-2019 дата публикации

Long-Throw Microfluidic Actuator

Номер: US20190017629A1
Автор: Droitcour Amy, Frey Jared, Laser Daniel, Negussie Hailemariam, Raduta Radu
Принадлежит:

A microfluidic device includes a three-dimensional slat structure having a plurality of interstices configured to generate a high power, high flow rate of fluids by electroosmotic flow. The microfluidic device includes a housing for holding and moving fluids through the slat structure, and a plurality of electrodes that generate an electric field within the plurality of interstices. 156.-. (canceled)57. A microfluidic cartridge comprising:a plurality of fluid passageways;at least one junction connecting said plurality of fluid passageways; and {'sup': '−8', 'a fluid power generation capacity of at least 10watts and capable of sustaining said power for at least 30 seconds; and'}, 'at least two fluid transport means, including at least one high-performance fluidic actuator, the at least one high-performance fluidic actuator being a discrete component within the cartridge, and the at least one high-performance fluidic actuator havinga response time for fluid power generation of less than 10 seconds.58. The cartridge of claim 57 , wherein said cartridge has a displaced volume less than or equal to five hundred cubic centimeters or less than or equal to fifty cubic centimeters.59. The cartridge of claim 57 , wherein said at least one high-performance fluidic actuator is capable of transducing electrical power into fluidic power.60. The cartridge of claim 57 , wherein said actuator is capable of pressurizing at least 10 microliters of liquid claim 57 , such that said liquid flows through a fluidic resistance associated with a back pressure of at least 1 kPa at a flow rate of at least 0.1 mL per minute.61. The cartridge of claim 57 , wherein said high-performance actuator is coupled to a pulse generator or other controlled time-varying voltage source and at least one electrode.62. The cartridge of claim 57 , wherein said at least one high-performance fluidic actuator is capable of producing fluidic power through an electrokinetic effect.63. The cartridge of claim 62 , ...

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Номер записи: 34
16-01-2020 дата публикации

SUB-PASCAL UNIDIRECTIONAL FLOW VALVES

Номер: US20200017813A1
Автор: Chen Christopher S., Chopra Anant, Michas Christos, White Alice Elizabeth
Принадлежит:

A valve includes a body including an inner bore extending between a first port and a second port, a seat, and one or more restrainers and a disk that is moveable between the seat and the one or more restrainers such that a first pressure that is less than 1 pascal and applied in a first direction causes the disk to move from a first position towards a second position to permit fluid communication between the first port and the second port. A metamaterial scaffold including a structure defining a lumen, at least a portion of an outer or non-lumen surface of the structure is coated with a plurality of biological cells, and wherein the structure is composed of a metamaterial. 1. A valve comprising:a body including an inner bore extending between a first port and a second port, a seat, and one or more restrainers; anda disk that is moveable between the seat and the one or more restrainers such that (i) a first pressure that is less than 1 pascal and applied in a first direction causes the disk to move from a first position towards a second position to permit fluid communication between the first port and the second port and (ii) a second pressure that is less than 1 pascal and applied in a second opposing direction causes the disk to move from the second position towards the first position to inhibit fluid communication between the first port and the second port.2. The valve of claim 1 , wherein the first pressure and the second pressure are less than 0.5 pascals.3. The valve of claim 1 , wherein the first pressure is between about 0.1 pascals and about 0.5 pascals.4. The valve of claim 1 , wherein the second pressure is between about 0.05 pascals and about 0.2 pascals.5. The valve of claim 1 , wherein the disk is moveable such that the first pressure causes the disk to move from the first position to the second position in less than 500 milliseconds.6. The valve of claim 1 , wherein the body is cylindrical and has a first diameter is that is 400 microns or less and a ...

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Номер записи: 35
22-01-2015 дата публикации

DEVICE WITH ROTARY VALVE FOR THE MANIPULATION OF LIQUIDS

Номер: US20150020904A1
Автор: Böttcher Heiko, Gärtner Claudia, Klemm Richard
Принадлежит: MICROFLUIDIC CHIPSHOP GmbH

The present invention describes a device consisting of a rotor, a holding-down device, and a base plate. The base plate is normally a fluidic system, a planar fluidic system for example or a fluidic system with several fluidic ports for a directed guidance of liquids or gases through different channels, channel systems, cavities or tubing, for the combination liquid and gas streams, or for prevention of liquid flows. 1. A system consisting of a rotor located inside of a holding-down device , said rotor will be being pressed onto a base plate by a by the holding-down device , wherein the base plate possesses openings from one or more channels , which open out into fluidic structures of the rotor mounted on the base plate , in order to guarantee a directed flow of liquids or gases in different channels , channel systems , cavities , or tubing , to facilitate their coupling or to inhibit any flow of liquids or gases.21. The system of , in which the base plate is a fluidic or microfluidic system and the holding-down device is formed like a cap and presses the rotor tightly onto the counter structure of the base plate.3. The system of claim 1 , in which the rotor is mounted between to plates claim 1 , which press him with sufficiently high initial tensions against the counter structure of one plate resulting in a microfluidic system with several layers.4. The system of claim 1 , in which the rotor is mounted between to plates claim 1 , which press him with sufficiently high initial tensions against the counter structure of one plate resulting in a microfluidic system with several layers and resulting in a rotor with through holes or slits claim 1 , and claim 1 , as a consequence claim 1 , giving rise to a system claim 1 , where openings from channels of the lower plate can be connected with openings from channels of the upper plate via the rotor.5. The system of in which at least one additional structured plate is added resulting in a system with multiple layers claim 3 ...

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Номер записи: 36
21-01-2021 дата публикации

Membraneless fluidic devices

Номер: US20210018102A1
Автор: Andrew Arthur Stanley, Casey Glick, Erik Samuel Roby, Serol Turkyilmaz
Принадлежит: Facebook Technologies LLC

Example devices include a fluidic device, such as a fluidic valve, including a body formed from a rigid body material including a fluidic source, a fluidic drain, and a fluidic gate, each of which may have a fluid connection with a chamber, or a portion thereof. The device may further include a gate transmission element, located within the chamber, that is controllable between at least a first position and a second position using a gate pressure received through the fluidic drain. Adjustment of the position of the gate transmission element may allow control of fluid flow through the device. Other devices, methods, systems, and computer-readable media are also disclosed.

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Номер записи: 37
21-01-2021 дата публикации

CHANNEL CHIP

Номер: US20210018104A1
Автор: Ono Koichi, SUNAGA Nobuya
Принадлежит:

A channel chip having a channel for running a fluid that is opened and closed by sliding on a film a sliding member slidable on the film while contacting with the film, the channel chip comprising: a substrate including a first channel, a second channel and a partition wall formed between the first channel and the second channel; a film including a diaphragm having a substantially spherical crown shape, the film being disposed on the substrate so that the diaphragm faces the partition wall; and a positioning section for holding the sliding member in such a way that the sliding member is slidable on the film while the positioning section positions the sliding member, the positioning section being disposed on the film. 1. A channel chip having a channel for running a fluid that is opened and closed by sliding on a film a sliding member slidable on the film while contacting with the film , the channel chip comprising:a substrate including a first channel, a second channel and a partition wall formed between the first channel and the second channel;a film including a diaphragm having a substantially spherical crown shape, the film being disposed on the substrate so that the diaphragm faces the partition wall; anda positioning section for holding the sliding member in such a way that the sliding member is slidable on the film while the positioning section positions the sliding member, the positioning section being disposed on the film.2. The channel chip according to claim 1 , wherein the sliding member is a rotary member which is rotatable.3. The channel chip according to claim 1 , wherein the positioning section is a frame for holding the sliding member in such a way that the sliding member is slidable on the film. This application is a continuation of U.S. patent application Ser. No. 16/324,179, filed on Feb. 8, 2019, which is National Stage Application of International Application No. PCT/JP2017/028175, filed on Aug. 3, 2017, the disclosure of which, including the ...

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Номер записи: 38
22-01-2015 дата публикации

Fluid handling device and fluid handling method

Номер: US20150021501A1
Автор: Ken Kitamoto, Koichi Ono
Принадлежит: Enplas Corp

A micro fluid chip includes a first chip and a second chip. The first chip includes a first substrate having a fluid channel and a partition wall, and a first film made of resin. The second chip includes a second substrate having a recess, and a second film made of elastomer. The second film has an elastic modulus higher than that of the first film. The first chip and the second chip are stacked in such a manner that the partition wall and the recess face each other with the first film and the second film therebetween. By setting the inner side of the recess to a negative pressure, a gap is formed between the first film and the partition wall, and thus a fluid channel is opened.

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Номер записи: 39
22-01-2015 дата публикации

MICROFLUIDIC DEVICES WITH MECHANICALLY-SEALED DIAPHRAGM VALVES

Номер: US20150021502A1
Автор: Vangbo Mattias
Принадлежит:

This invention provides a fluidic device comprising a diaphragm valve having a fluidics layer, an actuation layer and an elastic layer between the fluidics layer and the actuation layer, the elastic layer having a diaphragm that is mechanically sealed against the fluidics layer and the actuation layer by a sealing ring in the actuation layer. 13-. (canceled)4. A device comprising at least one diaphragm valve comprised in a combination that comprises a fluidics layer , an actuation layer and an elastic layer sandwiched between the fluidics layer and the actuation layer , wherein a diaphragm in each diaphragm valve is comprised in the elastic layer and is mechanically sealed against the fluidics layer and against the actuation layer by a raised sealing ring in the actuation layer.5. (canceled)6. The device of claim 4 , further comprising a mechanical fastener configured to fasten the combination into a sandwich claim 4 , wherein the mechanical fastener transmits pressure to a pressure seal.7. The device of claim 6 , wherein the mechanical fastener is selected from a screw claim 6 , a clip claim 6 , a snap claim 6 , a staple claim 6 , a rivet claim 6 , a band and a pin.8. The device of claim 4 , wherein the elastic layer comprises a urethane claim 4 , a nitrile claim 4 , a latex or silicone.9. The device of claim 4 , wherein the at least one diaphragm valve is a plurality of diaphragm valves.10. The device of claim 4 , wherein each diaphragm valve comprises:a) a valve seat against which the diaphragm is configured to sit;b) a valve relief defined at least in part by the sealing ring into which the diaphragm is configured to be deflected, thereby defining a valve chamber; andc) a valve inlet and a valve outlet comprised in the fluidics layer and in fluid communication with the valve chamber,wherein the diaphragm is configured to be actuated by positive or negative pressure transmitted through an actuation conduit in the actuation layer that communicates with the valve ...

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Номер записи: 40
25-01-2018 дата публикации

FLUID-BASED GATING MECHANISM WITH TUNABLE MULTIPHASE SELECTIVITY AND ANTIFOULING BEHAVIOR

Номер: US20180023728A1
Автор: Aizenberg Joanna, HOU Xu, KHAN Mughees, TESLER Alexander
Принадлежит:

A gating mechanism that uses a capillary stabilized liquid as a reversible, reconfigurable gate that fills and seals pores in the closed state, and creates a non-fouling, liquid-lined pore in the open state is disclosed. Theoretical modeling and experiments demonstrate that for each transport substance, the gating threshold—the pressure needed to open the pores—can be rationally tuned over a wide pressure range. This enables realizing in one system differential response profiles for a variety of liquids and gases, even letting liquids flow through the pore while preventing gas from escaping. These capabilities allow dynamic modulation of gas-liquid sorting and to separate multi-phase mixtures, with the liquid lining ensuring sustained antifouling behavior. Because the liquid gating strategy enables efficient short-term and long-term operation and can be applied to a variety of pore structures and membrane materials, and to nano, micro as well as macroscale fluid systems, the gating systems is useful in a wide range of applications. 1. A gating membrane device comprising:a membrane comprising a plurality of pores, wherein at least one pore of said plurality of pores has a continuous path that traverses a thickness of the membrane, the membrane positioned and arranged to permit a transport fluid to traverse the membrane thickness;a wetting liquid filling the at least one pore of said plurality of pores,wherein the wetting liquid partially displaces above a threshold pressure applied across said at least one pore to allow transport of the transport fluid through the membrane while contacting the wetting liquid,wherein the wetting liquid is selected to be immiscible with the transport fluid, andwherein the wetting liquid refills the at least one pore and gate transport of the transport fluid across the membrane below the threshold pressure.2. The gating membrane device of claim 1 , wherein the membrane is a polymer claim 1 , a ceramic claim 1 , a composite or a metal.3. ...

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Номер записи: 41
24-01-2019 дата публикации

Fluid delivery device with hydrophobic surface

Номер: US20190024823A1
Автор: Steven L. Wright, Yang Liu
Принадлежит: International Business Machines Corp

Embodiments of the present invention are directed to a liquid delivery apparatus. A non-limiting example of the apparatus includes a substrate including a cavity formed in a surface of the substrate. The apparatus can also include a membrane disposed on the surface of the substrate covering an opening of the cavity. The apparatus can also include a hydrophobic layer disposed on the membrane. The apparatus can also include a seal disposed between the membrane and the substrate, wherein the seal surrounds the opening of the cavity. The apparatus can also include an electrode layer coupled to the membrane.

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Номер записи: 42
23-01-2020 дата публикации

LOW FORCE VALVES FOR DRUG DELIVERY PUMPS

Номер: US20200025310A1
Автор: Allis Daniel, MCLAUGHLIN Ian
Принадлежит:

Disclosed are examples of valve systems and methods of operating the respective valve systems. An example valve system may include a valve body, an inlet component, an outlet component and a valve tube. The valve body may include a first void and a second void. The inlet component may be coupled to the first void and the outlet component may be coupled to the second void. The valve tube may include a side port and may be positioned through the valve body and coupled to the first void, the inlet component, the second void, and the outlet component. Other valve system examples may include including a valve body, a first septum, a second septum, a first piston, a second piston and a tube. The disclosed methods describe the interaction of the respective components of the respective valve system example. 1. A valve system , comprising:a valve body comprising a first void and a second void;an inlet component coupled to the first void;an outlet component coupled to the second void;a valve tube positioned through the valve body and coupled to the first void, the inlet component, the second void, and the outlet component, the valve tube comprising a side port.2. The valve system of claim 1 , wherein the valve system comprises a low actuation force claim 1 , micro claim 1 , no fluid displacement valve.3. The valve system of claim 1 , wherein the inlet component is coupled to a reservoir storing a fluid.4. The valve system of claim 1 , wherein the outlet component is coupled to a fluid path component coupled to a patient.5. The valve system of claim 4 , wherein the fluid path component comprises a cannula.6. The valve system of claim 1 , wherein the valve system is configured to be coupled to a pump head.7. The valve system of claim 6 , wherein the pump head comprises a pump piston and a pump chamber claim 6 , wherein the valve tube is coupled to the pump chamber.8. The valve system of claim 7 , wherein during a first stage of operation claim 7 , the side port is aligned with ...

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Номер записи: 43
23-01-2020 дата публикации

THREE-WAY MICROVALVE DEVICE AND METHOD OF FABRICATION

Номер: US20200025311A1
Автор: Huff Michael A.
Принадлежит:

A three-way (3-way) Micro-Electro-Mechanical Systems (MEMS)-based micro-valve device and method of fabrication for the implementation of a three-way MEMS-based micro-valve are disclosed. The micro-valve device has a wide range of applications, including medical, industrial control, aerospace, automotive, consumer electronics and products, as well as any application(s) requiring the use of three-way micro-valves for the control of fluids. The discloses three-way micro-valve device and method of fabrication that can be tailored to the requirements of a wide range of applications and fluid types, and can also use a number of different actuation methods, including actuation methods that have very small actuation pressures and energy densities even at higher fluidic pressures. This is enabled by a novel pressure-balancing scheme, wherein the fluid pressure balances the actuator mechanism so that only a small amount of actuation pressure (or force) is needed to switch the state of the actuator and device from open to closed, or closed to open. 1. A method of fabricating a three-way pressure-balanced micro-valve device , the method comprising:providing a bottom substrate,micomachining the bottom substrate so as to form in the bottom substrate a bottom fluid chamber having a depth extending partially into the bottom substrate,forming in the bottom substrate at least one fluid port that passes completely through the bottom substrate, so as to fluidically connect to the bottom fluid chamber,providing a top substrate,micomachining the top substrate so as to form in the top substrate a top fluid chamber having a depth extending partially into the top substrate, andforming in the bottom substrate at least at least one fluid port that passes completely through the bottom substrate so as to fluidically connect to the bottom fluid chamber, andproviding a middle substrate, andthinning the middle substrate so as to be a membrane layer in the region of where the fluid chamber is ...

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Номер записи: 44
23-01-2020 дата публикации

CENTRIFUGAL VALVE CONTROL APPARATUS

Номер: US20200025312A1
Автор: KIM Min Seok
Принадлежит:

Provided is a centrifugal valve control apparatus including: a body part including a body having a chamber and a channel connected to the chamber, and a valve configured to open and close the channel; a heating part coupled to the body and including a heating member disposed at a position corresponding to the valve; and a rotation driving part configured to rotate the body part and the heating part together, wherein the valve is formed to open and close the channel by the heating member while the body part and the heating part rotate together. Accordingly, the valve of the centrifugal valve control apparatus may be accurately controlled. 1. A centrifugal valve control apparatus comprising:a body part including a body having a chamber and a channel connected to the chamber, and a valve configured to open and close the channel;a heating part coupled to the body, and including a heating member disposed at a position corresponding to the valve; anda rotation driving part configured to rotate the body part and the heating part together,wherein the valve is formed to open and close the channel by the heating member while the body part and the heating part rotate together.2. The centrifugal valve control apparatus of claim 1 , wherein:the body is formed of a tube having a predetermined height; andthe heating part is formed of a substrate.3. The centrifugal valve control apparatus of claim 1 , wherein:each of the chamber and the channel is provided in the body.4. The centrifugal valve control apparatus of claim 1 , wherein:the valve is provided in the body; andthe heating member is provided at a lower part of the heating part.5. The centrifugal valve control apparatus of claim 1 , further comprising a battery configured to supply power to the heating member.6. The centrifugal valve control apparatus of claim 1 , wherein:the channel and the valve formed in the channel are provided in plural in the body; andthe heating members corresponding to the valves are provided in the ...

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Номер записи: 45
02-02-2017 дата публикации

MICROFLUIDICS MODULE AND CARTRIDGE FOR IMMUNOLOGICAL AND MOLECULAR DIAGNOSIS IN AN ANALYSIS MACHINE

Номер: US20170028403A1
Автор: KRAUSE Ulrich
Принадлежит:

The invention relates to a microfluidics module () for both the immunological and molecular diagnosis of samples, wherein channels () and/or cavities () having inlets (-) for fluid samples and reagents, as well as inlet-assigned containers, container receiving means or container anchoring points are formed in a main body, and which module has a detection channel (), for receiving a test-specific detection medium, that can be connected with channels () of the module. A central multi-port valve () is essential for the function, and controllably connects individual channels () on the module. The channels belong to channel structures which are assigned certain functions and which are all directly or indirectly connected to the multi-port valve (), wherein at least sections of the channel structures and channels form circuits (), the channels () and/or cavities () of which circuits are at least partially arranged close to the base surface (), in order to permit procedures, controlled by the analysis device, within the test process. The invention also relates to a cartridge () for receiving a microfluidics module (), a reagent module (), and a method for carrying out both immunological and, optionally, molecular tests using the microfluidics module (). 1. A microfluidics module configured both for the immunological and molecular diagnostics of samples , in which channels and/or cavities having inlets for fluid samples and reagents , are configured in a base body , wherein containers , container accommodators or container attachment points are assigned to the inlets , and a detection channel for accommodating an assay-specific detection means connected or connectable to channels of the module , comprising:exactly one multiport valve which connects individual channels;channel structures including i) at least channels and/or cavities for sample guidance which include conditioning necessary for certain assays, ii) channels for reagent feeding, iii) a channel structure with ...

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Номер записи: 46
30-01-2020 дата публикации

MICROFLUIDICS VALVE

Номер: US20200030799A1
Автор: BALDI COLL Antonio, DÍAZ GONZÁLEZ María, FERNÁNDEZ SÁNCHEZ César, MUÑOZ BERBEL Francesc Xavier
Принадлежит:

A microfluidics valve comprises at least two substrates () between which there is at least a microchannel (). It additionally comprises at least a barrier () of a meltable material, placed in the microchannel. The valve further comprises at least an optical heater () placed in correspondence with the barrier () and at least a section of one of the substrates (), in correspondence with the optical heater (), is transparent. The optical heater is a colored line that, when is illuminated with a light source, is heated and releases the heat to the barrier () thus melting the part of it that is closer to the line. 2614. Microfluidics valve according to characterized in that the optical heater () is placed in one of the substrates () and is facing the barrier ().364. Microfluidics valve according to characterized in that the optical heater () is in contact with the barrier ().46. Microfluidics valve according to characterized in that the optical heater () is a feature made of a photothermal material that can absorb light energy in a range of frequencies.561. Microfluidics valve according to characterized in that the optical heater () is a printed dark colored line placed in one of the substrates ().6356. Microfluidics valve according to characterized in that one of the substrates comprises at least a hole () in correspondence with the microchannel () and facing the optical heater ().765496. Microfluidics valve according to characterized in that it comprises a first optical heater () placed in the microchannel () in correspondence with the barrier () and at least an additional optical heater () placed in one side of the first optical heater ().896. Microfluidics valve according to characterized in that it comprises two additional optical heaters () placed each at one side of the first optical heater ().994. Microfluidics valve according to characterized in that the additional optical heaters () do not project out of the barrier () at any point.10. Microfluidics valve ...

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Номер записи: 47
12-02-2015 дата публикации

Fluid Triggerable Valves

Номер: US20150040999A1
Автор: Ender YILDIRIM, Paul Vulto, Sebastiaan Johannes TRIETSCH
Принадлежит: UNIVERSITEIT LEIDEN

The present invention relates to a fluid triggerable passive valve for controlling flow of one or more fluids comprising: a volume comprising at least two capillary pressure barriers for respectively pinning a first and second fluid-fluid meniscus, the two capillary pressure barriers dividing the volume in at least three sub volumes, whereby two sub volumes being positioned upstream and one sub volume being positioned downstream with respect to the advancement direction of each respective fluid-fluid meniscus; wherein the capillary pressure barriers are spaced apart such that upon pinning of a first fluid-fluid meniscus on a first capillary pressure barrier and arrival or pinning of a second fluid-fluid meniscus on or at a second capillary pressure barrier, the two menisci touch and thereby coalesce into one fluid-fluid meniscus

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Номер записи: 48
06-02-2020 дата публикации

MICROFLUIDIC CHIP WITH SEALED ON-BOARD REAGENT

Номер: US20200038855A1
Автор: CHEN Dafeng, Deshpande Manish, RASMUSSEN James E.
Принадлежит: SIEMENS HEALTHCARE DIAGNOSTICS INC.

A microfluidic product pouch assembly may be used in a microfluidic chip. The microfluidic product pouch may include a pouch surrounding an inner chamber and having a rupturing portion and an inner membrane positioned within the inner chamber. The inner membrane may separate the inner chamber into a first cavity and a second cavity. A reagent may be positioned within the first cavity and/or the second cavity. The microfluidic product pouch assembly may also include a rupturing structure. The rupturing structure may be configured to selectively break the rupturing portion of the microfluidic product pouch. 1. A microfluidic product pouch assembly for use in a microfluidic chip , comprising:a pouch surrounding an inner chamber and having a rupturing portion;an inner membrane positioned within the inner chamber to form a first cavity and a second cavity;a reagent in fluid form within the first cavity; anda rupturing structure configured to selective break the rupturing portion,wherein the second cavity houses a gas stored under pressure such that rupturing the rupturing portion causes a pressure imbalance whereby the inner membrane deforms into the first cavity and pushes the contents of the first cavity into a channel of the microfluidic chip.26.-. (canceled)7. The microfluidic product pouch of claim 1 , wherein the pouch rupturing structure is a pin claim 1 , the pin having a sharp edge configured to penetrate the rupturing portion.8. The microfluidic product pouch of claim 1 , wherein the pouch rupturing structure is a plunger.9. The microfluidic product pouch of claim 8 , wherein the plunger includes a rod connected to a contact member having a substantially flat surface.10. The microfluidic product pouch of claim 9 , wherein the pouch further includes a deformable membrane claim 9 , the flat surface of the plunger configured to provide pressure to the deformable membrane to break the rupturing portion of the pouch.11. The microfluidic product pouch of claim 9 , ...

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Номер записи: 49
12-02-2015 дата публикации

MICROFLUIDIC DEVICE FOR SERIAL FLUIDIC OPERATIONS

Номер: US20150044696A1
Автор: DOTHIE Pamela Ann, SPENCER Daniel Christopher
Принадлежит: SHARP KABUSHIKI KAISHA

An integrated microfluidic device for carrying out a series of fluidic operations includes a housing including a plurality of n microfluidic conduits, wherein n is at least three, and a rotating valve having an internal channel with an entrance port and an exit port that are angularly separated. The rotating valve is positionable in a first position to connect two of the n fluidic conduits via the internal channel, and upon rotating the valve to a second position, two other of the n fluidic conduits are connected by the internal channel. The device further may include one or more fluidic chambers in fluid communication with respective fluidic conduits. Fluid contained in one fluidic chamber is transferrable by application of positive or negative gas pressure through associated fluidic conduits into another fluidic chamber via the internal channel. The device may be utilized to perform a variety of fluidic operations. 1. An integrated microfluidic device for carrying out a series of fluidic operations comprising:a housing including a plurality of n microfluidic conduits, wherein n is at least three; anda rotating valve having an internal channel with an entrance port and an exit port that are angularly separated;wherein the rotating valve is positionable in a first position to connect two of the n fluidic conduits via the internal channel, and upon rotating the valve to a second position, two of the n fluidic conduits, including at least one fluidic conduit different from the fluidic conduits connected in the first position, are connected by the internal channel; andwherein in either the first position or the second position, two sequentially adjacent fluidic conduits are connected via the internal channel.2. The integrated microfluidic device of claim 1 , wherein the two of the n fluidic conduits connected in the second position includes at least one of the fluidic conduits connected to the internal channel in the first position.3. The integrated microfluidic device ...

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Номер записи: 50
24-02-2022 дата публикации

Microelectronic thermal valve

Номер: US20220057018A1
Автор: Alina Alexeenko, Anthony George Cofer, Stephen Douglas Heister
Принадлежит: PURDUE RESEARCH FOUNDATION

A microfabricated valve with no moving parts. In one embodiment, the valve includes a reservoir of a liquid that is in fluid communication with an outlet channel having a throat that is less than 100 microns wide. Preferably, the channel is an elongated slit. The configuration of channel is adapted and configured such that surface tension of the liquid prevents flow out of the channel. A heater increases the temperature of the meniscus of the fluid, until a portion of the fluid is ejected from the channel. The ejection of the fluid creates both a thrusting effect and a cooling effect.

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Номер записи: 51
24-02-2022 дата публикации

IMPROVED VALVE

Номер: US20220057019A1
Автор: BUMBY James Samuel, HATFIELD Stuart
Принадлежит:

A valve includes a first plate, a second plate, a spacer disposed between the first plate and the second plate, and a flap movably disposed between the first plate and the second plate. The first plate includes a plurality of first apertures extending through said first plate and the second plate includes a plurality of second apertures extending through said second plate. The second apertures are substantially offset from the first apertures. The spacer forms a cavity between the first plate and the second plate and is in fluid communication with the first apertures and the second apertures. The flap has apertures substantially offset from the first apertures and substantially aligned with the second apertures, and the flap is operable to be motivated between said first and second plates in response to a change in direction of the differential pressure of the fluid across the valve. 1. A valve for controlling fluid flow , the valve comprising:a first plate comprising a plurality of first apertures extending generally perpendicular through said first plate;a second plate comprising a plurality of second apertures extending generally perpendicular through said second plate, the second apertures being substantially offset from the first apertures of said first plate;a spacer disposed between said first plate and said second plate to form a cavity therebetween in fluid communication with the first apertures of said first plate and the second apertures of said second plate;a flap disposed and moveable between said first plate and said second plate, the flap having apertures substantially offset from the first apertures of said first plate and substantially aligned with the second apertures of said second plate;wherein the flap is operable to be motivated between said first and second plates in response to a change in direction of a differential pressure of the fluid across the valve; andwherein at least one of said first plate or said second plate comprises one or more ...

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Номер записи: 52
16-02-2017 дата публикации

Systems and methods for facilitating fluid flow during enhanced detection and quantification of analytes

Номер: US20170043334A1
Автор: Ayub Khattak, Clinton Sever, Justin Demartino, Mark Duncan, Paul Nelson, Raphael Shapiro, Ryan Cooper, Thomas Congdon
Принадлежит: Cue Health Inc

Devices, systems, and methods for detecting molecules of interest within a collected sample are described herein. In certain embodiments, self-contained sample analysis systems are disclosed, which include a reusable reader component, a disposable cartridge component, and a disposable sample collection component. The reader component may communicate with a remote computing device for the digital transmission of test protocols and test results. In various disclosed embodiments, the systems, components, and methods are configured to identify the presence, absence, and/or quantity of particular nucleic acids, proteins, or other analytes of interest, for example, in order to test for the presence of one or more pathogens or contaminants in a sample.

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Номер записи: 53
16-02-2017 дата публикации

Cartridges, collectors, kits, and methods for enhanced detection and quantification of analytes in collected fluid samples

Номер: US20170043335A1
Автор: Ayub Khattak, Clinton Sever, Justin Demartino, Mark Duncan, Paul Nelson, Raphael Shapiro, Ryan Cooper, Thomas Congdon
Принадлежит: Cue Health Inc

Devices, systems, and methods for detecting molecules of interest within a collected sample are described herein. In certain embodiments, self-contained sample analysis systems are disclosed, which include a reusable reader component, a disposable cartridge component, and a disposable sample collection component. The reader component may communicate with a remote computing device for the digital transmission of test protocols and test results. In various disclosed embodiments, the systems, components, and methods are configured to identify the presence, absence, and/or quantity of particular nucleic acids, proteins, or other analytes of interest, for example, in order to test for the presence of one or more pathogens or contaminants in a sample.

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Номер записи: 54
15-02-2018 дата публикации

COMPOUNDING DEVICE, SYSTEM, KIT, SOFTWARE, AND METHOD

Номер: US20180043323A1
Автор: Janders Mike, Lane Benjamin R., Mumpower Mariano
Принадлежит:

An exemplary pharmaceutical compounding system and device for mixing materials from at least two distinct material sources can include a transfer set and junction structure that has a junction body, a first inlet port located at a first portion of the junction body, a second inlet port located at a second portion of the junction body, and an outlet port located at a third portion of the junction body. A mixing chamber can be located between the outlet port and both the first inlet port and second inlet port, the mixing chamber configured to mix fluid received from both the first inlet port and second inlet port and to deliver the fluid to the outlet port. An attachment structure can be located on the junction body and configured to attach the junction structure to the housing of the compounding device. 1. A junction structure for use in a pharmaceutical compounding device , the compounding device having a housing that supports a pump system and a valving mechanism , the junction structure comprising:a junction body having a longitudinal axis and two lateral sides extending along either side of the longitudinal axis, the junction body further including a front side and a rear side each extending between the two lateral sides at opposite ends of the junction body;a first inlet port located at one of two lateral sides of the junction body such that a first inlet conduit intersects the one of the two lateral sides of the junction body;a second inlet port located at another of the two lateral sides of the junction body such that a second inlet conduit intersects the another of the two lateral sides of the junction body;an outlet port located at a third portion of the junction body;a mixing chamber located between the outlet port and both the first inlet port and second inlet port, the mixing chamber configured to mix fluid received from both the first inlet port and second inlet port and to deliver the fluid to the outlet port; andan attachment structure located on the ...

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Номер записи: 55
15-02-2018 дата публикации

Method of manufacturing microfluidic chip and a microfluidic chip made thereby

Номер: US20180043359A1
Автор: Sung-Yi Yang, Yi-Cheng Lin
Принадлежит: Taiwan Green Point Enterprise Co Ltd

A method of manufacturing a microfluidic chip includes providing an upper mold having multiple upper ribs extending along a second direction, and a lower mold having multiple lower ribs extending along a first direction different from the second direction, forming a forming material in a filling space defined by the upper and lower molds to provide a channeled plate having multiple upper microfluidic channels complementary in shape to the upper ribs, lower microfluidic channels complementary in shape to the lower ribs, and multiple thin film valves formed at intersections where the upper microfluidic channels intersect the lower microfluidic channels, separating the upper and lower molds, and covering the lower and upper microfluidic channels.

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Номер записи: 56
19-02-2015 дата публикации

VALVE FOR DISPENSING A FLUID

Номер: US20150050186A1
Автор: Bammesberger Stefan Borja, Kartmann Sabrina, Koltay Peter, Mutschler Klaus, Spinke Juergen, Tanguy Laurent
Принадлежит:

A valve for dispensing a fluid comprising a dry portion and a wet portion is presented. Only the wet portion is contacted by the fluid. The wet portion comprises a fluid dispenser unit having a inlet opening, a capillary nozzle providing a fluid outlet, a cavity, the capillary nozzle having an end within the cavity, and a plunger. The plunger moves within the cavity into an opening position allowing an inflow of the fluid through the inlet opening through the cavity and an outflow of the fluid through the capillary nozzle. The plunger has a sealing surface directed towards the end of the capillary nozzle. The plunger moves into a closing position for sealing the end of the capillary nozzle with the sealing surface. The dry portion comprises a closing component for exercising a magnetic closing force onto the plunger for attracting the plunger into the closing position. 1. A valve for dispensing a fluid comprising a dry portion and a wet portion , wherein only the wet portion is contacted by the fluid , the wet portion comprising:a fluid dispenser unit having a fluid inlet opening,a capillary nozzle providing a fluid outlet,a cavity, wherein the capillary nozzle has an end within the cavity, anda plunger, wherein the plunger is movable within the cavity into an opening position by an actuation unit allowing an inflow of the fluid through the fluid inlet opening through the cavity and an outflow of the fluid through the capillary nozzle, wherein the plunger has a sealing surface at its side directed towards the end of the capillary nozzle, and wherein the plunger is movable into a closing position closing the end of the capillary nozzle by the sealing surface; and 'a closing component for exercising a magnetic closing force onto the plunger for moving the plunger into the closing position, wherein at least one of the closing component and the plunger comprises a permanent magnet for keeping the valve in its normally-closed state.', 'the dry portion comprising2. The ...

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Номер записи: 57
25-02-2016 дата публикации

MICROVALVE HAVING A REDUCED SIZE AND IMPROVED ELECTRICAL PERFORMANCE

Номер: US20160053916A1
Автор: Arunasalam Parthiban, Fuller E. Nelson, Gurley Gengxun Kara, Ojeda, SR. Joe A., Yang Chen
Принадлежит: DUNAN MICROSTAQ, INC.

A plate is adapted for use in a microvalve and includes a displaceable member configured for movement between a closed position, wherein the displaceable member prevents fluid communication through the microvalve, and an opened position, wherein the displaceable member does not prevent fluid communication through the microvalve. The displaceable member includes an elongated arm portion, a plurality of actuator ribs connected through a central spine to the elongated arm portion, and a hinge portion. The actuator ribs have a first portion and a second portion, the first portion having a first end and a second end, the second end of the first portion connected to the central spine, the second portion having a first end and a second end, the second end of the second portion connected to the central spine. A channel is formed in the plate. A plurality of elongated openings are formed in the plate and define the actuator ribs, each elongated opening having longitudinally extending side edges. One of the elongated openings separates each rib in the second portion of ribs from an adjacent rib or the plate. The channel and a longitudinally extending side edge of one of the elongated openings separate the second portion of the actuator ribs from the plate and define an electrical isolation region. 1. A plate adapted for use in a microvalve , the plate comprising:a displaceable member configured for movement between a closed position, wherein the displaceable member prevents fluid communication through the microvalve, and an opened position, wherein the displaceable member does not prevent fluid communication through the microvalve, the displaceable member including an elongated arm portion, a plurality of actuator ribs connected through a central spine to the elongated arm portion, and a hinge portion, the actuator ribs having a first portion and a second portion, the first portion having a first end and a second end, the second end of the first portion connected to the ...

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Номер записи: 58
13-02-2020 дата публикации

FLUIDIC PUMP AND LATCH GATE

Номер: US20200049175A1
Автор: Ochs Garett Andrew
Принадлежит:

A fluidic device comprises a first channel conduit, a valve apparatus, and an additional element adjacent to the first channel conduit. The first channel conduit transports fluid from a first fluid entrance to a fluid exit. In one embodiment, the additional element is a pump chamber that receives fluid from a second fluid entrance and pumps fluid into the first channel conduit in accordance with fluid pressure. Alternatively, the additional elements include a second channel conduit and a neck of the first channel conduit. The first channel conduit and the second channel conduit share a common wall. Fluid pressure in the first channel conduit controls a valve apparatus. The value apparatus controls a rate of fluid flow in the first channel conduit by deforming the common wall to change a cross-sectional area of the neck, which changes a rate of fluid flow in the second channel conduit. 1. (canceled)2. A valve apparatus for a fluidic device , comprising:a first segment coupled to a first inner surface of a chamber at a first coupling point, wherein the first segment is rotatable about the first coupling point to move between a first position and a second position;a second segment coupled to a second inner surface of the chamber at a second coupling point, wherein the second segment is rotatable about the second coupling point; anda third segment coupled to the first segment at a third coupling point and to the second segment at a fourth coupling point.3. The valve apparatus of claim 2 , wherein the third segment is rotatable about the third coupling point and about the fourth coupling point.4. The valve apparatus of claim 2 , further comprising a channel conduit that is in fluid communication with the chamber.5. The valve apparatus of claim 4 , wherein the channel conduit is in an open state when the first segment is in the first position and the channel conduit is in a closed state when the first segment is in the second position.6. The valve apparatus of claim 5 , ...

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Номер записи: 59
21-02-2019 дата публикации

Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples

Номер: US20190054471A1
Автор: Jeff Williams, Kalyan Handique, Kerry Wilson
Принадлежит: HandyLab Inc

The technology described herein generally relates to systems for extracting polynucleotides from multiple samples, particularly from biological samples, and additionally to systems that subsequently amplify and detect the extracted polynucleotides. The technology more particularly relates to microfluidic systems that carry out PCR on multiple samples of nucleotides of interest within microfluidic channels, and detect those nucleotides.

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Номер записи: 60
04-03-2021 дата публикации

FLUIDIC DEVICES WITH FREEZE-THAW VALVES WITH ICE-NUCLEATING AGENTS AND RELATED METHODS OF OPERATION AND ANALYSIS

Номер: US20210060564A1
Автор: Gaiteri Joseph Carl, Henley William Hampton, Ramsey John Michael
Принадлежит:

Embodiments of the invention provide fluidic devices such as, but not limited to, microfluidic chips, with one or more freeze thaw valves (FTVs) employing one or more ice-nucleating agents (INAs), that can reliably operate to freeze at relatively higher temperatures and/or at faster rates than conventional microfluidic devices with FTV systems. 1. A liquid buffer comprising at least one ice nucleating agent (INA) , wherein the at least one INA contains a carbon atom.2. The liquid buffer of claim 1 , wherein the at least one INA is present in the liquid buffer in an amount in a range of 1 molecule/4 to 10 billion molecules/4.3. The liquid buffer of claim 1 , wherein the at least one INA is present in the liquid buffer in a concentration range of about 1 nM and about 1 mM.4. The liquid buffer of claim 1 , wherein the at least one INA is present in the liquid buffer in a concentration range of 10 nM to 50 nM.5. The liquid buffer of claim 1 , wherein the at least one INA is extracted or derived from an organism.6. The liquid buffer of claim 1 , wherein the at least one INA comprises an ice-nucleating protein (INP) and/or a functional fragment thereof.7Pseudomonas syringae, Ps. fluorescens, Erwinia herbicola, E. uredovora, Pantoea ananatisXanthomonas campestris.. The liquid buffer of claim 6 , wherein the INP and/or the functional fragment thereof is encoded by a gene selected from the group consisting of: iceE claim 6 , iceH claim 6 , inaA claim 6 , inaE claim 6 , inaF claim 6 , inaK claim 6 , inaPb claim 6 , inaQ claim 6 , inaU claim 6 , inaV claim 6 , inaW claim 6 , inaX claim 6 , and inaZ claim 6 , and wherein the gene is found in or obtained from an organism selected from the group consisting of: claim 6 , and8. The liquid buffer of claim 1 , wherein the at least one INA comprises one or more aptamers.9. The liquid buffer of claim 1 , wherein the at least one INA comprises an ice-nucleating protein and/or a functional fragments thereof claim 1 , an ice-nucleating ...

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Номер записи: 61
12-03-2015 дата публикации

Electrodynamic Actuator

Номер: US20150069860A1
Автор: Dierks Johannes, FUCHS Maik, Hartmann Christian, REITER Cyril, SCHEIBE Ralf, SCHROEDER Raoul
Принадлежит:

An electrodynamic actuator, in particular for a microvalve or a micropump, includes a magnet arrangement for generating a magnetic field and a control element movable relative to the magnet arrangement. The control element includes an energizable air-core coil () which is arranged in the magnetic field and firmly coupled to a coil carrier () made from a nonmagnetic material. 1. An electrodynamic actuator , in particular for a microvalve or a micropump , the electrodynamic actuator comprisinga magnet arrangement for generating a magnetic field, anda control element movable relative to the magnet arrangement,{'b': 22', '20, 'the control element including an energizable air-core coil () which is arranged in the magnetic field and firmly coupled to a coil carrier () made from a nonmagnetic material.'}222222222ab. The electrodynamic actuator according to claim 1 , characterized in that a first half () of the air-core coil () is arranged in a first magnetic field having a first principal direction and the second half () of the air-core coil () is arranged in a second magnetic field having a second principal direction opposed to the first principal direction.322222222ab. The electrodynamic actuator according to claim 2 , characterized in that the air-core coil () generally has the shape of an oval with a longitudinal axis claim 2 , preferably the shape of a pair of complementary semicircles spaced from each other and having a linear middle piece connecting the semicircles claim 2 , the longitudinal axis dividing the air-core coil () into the two halves ( claim 2 , ).4. The electrodynamic actuator according to claim 1 , characterized in that the control element is mounted for linear movement in a direction (A) that is perpendicular to the principal directions of the magnetic fields.5. The electrodynamic actuator according to claim 1 , characterized in that the control element is mounted for swiveling movement about an axis of rotation (D) that is parallel to the principal ...

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Номер записи: 62
17-03-2022 дата публикации

FLUID HANDLING DEVICE AND FLUID HANDLING METHOD

Номер: US20220082170A1
Автор: Ono Koichi, SUNAGA Nobuya
Принадлежит:

A fluid handling device, comprising: a substrate including a first channel, a second channel and a partition wall formed between the first channel and the second channel; a film including a diaphragm, the film being disposed on the substrate so that the diaphragm faces the partition wall; and a sliding member slidable on the film while contacting with the film, the sliding member including a protrusion formed on an underside thereof, and the sliding member being disposed on the film with the underside facing the film, wherein: the sliding member is capable of switching between a first state and a second state by sliding on the film, wherein the protrusion is positioned so as not to face the partition wall with the diaphragm therebetween in the first state, and the protrusion is positioned so as to face the partition wall with the diaphragm therebetween in the second state. 1. A fluid handling device , comprising:a substrate including a first channel, a second channel and a partition wall formed between the first channel and the second channel;a film including a diaphragm, the film being disposed on the substrate so that the diaphragm faces the partition wall; anda sliding member slidable on the film while contacting with the film, the sliding member including a protrusion formed on an underside thereof, and the sliding member being disposed on the film with the underside facing the film, wherein:the sliding member is capable of switching between a first state and a second state by sliding on the film, wherein the protrusion is positioned so as not to face the partition wall with the diaphragm therebetween in the first state, and the protrusion is positioned so as to face the partition wall with the diaphragm therebetween in the second state;in the first state, the first channel communicates with the second channel via a gap between the diaphragm and the partition wall; andin the second state, the diaphragm is pressed by the protrusion to come into contact with the ...

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Номер записи: 63
17-03-2022 дата публикации

FLUID HANDLING DEVICE AND MANUFACTURING METHOD OF FLUID HANDLING DEVICE

Номер: US20220082180A1
Автор: YAMAUCHI Takumi
Принадлежит: Enplas Corporation

A fluid handling device includes: an introduction part configured to introduce liquid; an ejection part configured to eject liquid; a channel including one end connected to the introduction part and another end connected to the ejection part; and a valve disposed at the channel. An inner surface of the introduction part has water-repellency, and an inner surface of the ejection part and at least a part of an inner surface of the channel do not have water-repellency. 1. A fluid handling device comprising:an introduction part configured to introduce liquid;an ejection part configured to eject liquid;a channel including one end connected to the introduction part and another end connected to the ejection part; anda valve disposed at the channel,wherein an inner surface of the introduction part has water-repellency, andwherein an inner surface of the ejection part and at least a part of an inner surface of the channel do not have water-repellency.2. The fluid handling device according to claim 1 , wherein a bottom surface of the introduction part has a tapered shape.3. A method of manufacturing a fluid handling device claim 1 , the method comprising:preparing the fluid handling device, the fluid handling device including an introduction part configured to introduce liquid, an ejection part configured to eject liquid, a channel including one end connected to the introduction part and another end connected to the ejection part, and a valve disposed at the channel; andperforming a water-repellent treatment using a water-repellent agent on an inner surface of the introduction part by introducing the water-repellent agent from the introduction part with the valve closed.4. The method according to claim 3 , further comprising a step of removing the water-repellent agent from the introduction part in a state where inside of the introduction part is set to a negative pressure or inside of the ejection part is set to a positive pressure claim 3 , with the valve open. This ...

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Номер записи: 64
17-03-2022 дата публикации

METHOD FOR MANUFACTURING A MICROMECHANICAL DEVICE AND MICROMECHANICAL VALVE

Номер: US20220082181A1
Автор: KRUCKOW Juergen, LEISTNER Henry, Richter Martin, Wackerle Martin
Принадлежит:

A method for manufacturing at least one micromechanical device includes: 1. A method for manufacturing at least one micromechanical device , comprising:providing a first substrate and a separate second substrate, the first substrate comprising two surfaces spaced parallel to each other with a predetermined thickness, and the second substrate comprising two surfaces spaced parallel to each other with a predetermined thickness;patterning a first trench structure into one of the two surfaces of the first substrate, and patterning a second trench structure into one of the two surfaces of the second substrate;arranging the patterned surfaces of the two substrates with respect to each other such that a substrate stack with an upper surface and a lower surface is defined, and such that the first and/or second trench structure forms at least one cavity in the substrate stack;thinning the substrate stack from the upper and/or lower surface of the substrate stack;exposing the at least one cavity by patterning a recess into the upper and/or lower surface of the substrate stack,wherein, in the method, exposing the at least one cavity is performed after arranging the two substrates into the substrate stack.2. The method according to claim 1 , wherein exposing the at least one cavity is performed using a CMOS-compatible etching process.3. The method according to claim 1 , wherein the first substrate and/or the second substrate is a semiconductor substrate.4. The method according to claim 1 , wherein patterning the first and/or second trench structure and/or the recess in the first and/or second substrate is performed by means of a wet etching process and/or a dry etching process.5. The method according to claim 4 , wherein patterning by means of the wet etching process is performed prior to patterning by means of the dry etching process.6. The method according to claim 4 , wherein the wet etching process is performed with an aqueous solution claim 4 , the aqueous solution ...

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Номер записи: 65
08-03-2018 дата публикации

COMPOUNDING DEVICE, SYSTEM, KIT, SOFTWARE, AND METHOD

Номер: US20180065097A1
Автор: Ammermann Linda M., Bartholomew Joel, Janders Mike, JR. Karl, Konrad, Lane Benjamin R., Mumpower Mariano, Pearl Aaron S.
Принадлежит:

An exemplary manifold for a pharmaceutical ingredient compounding device can include a housing, at least one primary intake port including a primary valve to permit or block passage of at least one primary ingredient through the manifold, and a plurality of secondary intake ports. A first channel can be in fluid communication with the at least one primary valve and include an outlet port configured to outlet the at least one primary ingredient from the manifold. A second channel can be in fluid communication with a plurality of secondary valves and include an outlet port configured to outlet at least one of a plurality of secondary ingredients from the manifold. The first channel and second channel can be in fluid isolation from each other such that the at least one primary ingredient does not mix with the plurality of secondary ingredients within the manifold. 1. A manifold for a compounding device configured for compounding pharmaceutical ingredients , comprising:a housing having a top surface and a bottom surface;at least one primary intake port extending away from the top surface of the housing and including a primary valve configured to open and close the at least one primary intake port to permit or block passage of at least one primary ingredient through the manifold, the at least one primary intake port having a primary intake port axis along which ingredients flow when entering the manifold during use;a plurality of secondary intake ports located on the first side of the housing, each of the secondary intake ports including a secondary valve configured to open and close a respective one of the plurality of secondary intake ports to permit or block passage of a plurality of secondary ingredients through the manifold, the plurality of second intake ports each having a secondary intake port axis along which one of the secondary ingredients flows when entering the manifold during use, and at least one secondary intake port axis is parallel with the primary ...

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Номер записи: 66
09-03-2017 дата публикации

Atherofluidics-On-Chip

Номер: US20170065976A1
Автор: Varma Sarvesh, Voldman Joel
Принадлежит:

Endothelial cells can become susceptible to disease when subjected to disturbed (atheroprone) blood flow patterns, which naturally occur in known locations in human arteries. Atheroprone flow is non-laminar, with low fluid shear stress magnitude and an oscillatory pattern representative in the temporal signature. At a macro-scale, atheroprone flow is multidirectional and chaotic. On the other hand, atheroprotective flow is laminar with high fluid shear stresses that have a specific temporal signature. Therefore, understanding the interplay between the atheroprotective and atheroprone hemodynamics and endothelial function is important. The invention relates, in some embodiments, to microfluidic devices and methods that dynamically apply controlled and physiologically relevant spatio-temporal atheroprone and atheroprotective flow signatures. Further, some embodiments according to the invention recreate these flow profiles upon different regions of the same cell culture, more closely resembling the in-vivo phenomenon. 1. A flow modulator , comprising:an inlet for receiving an input flow;an outlet for discharging an output flow, the outlet being in fluid communication with the inlet;a control module capable of controlling an amplitude and a frequency of the output flow.2. The flow modulator of claim 1 , wherein the input flow is received from a pump.3. The flow modulator of claim 1 , wherein the flow modulator is a microfluidic device.4. The flow modulator of claim 1 , further comprising an outlet conduit connected to the outlet and having an end adapted for connection to a microfluidic port.5. The flow modulator of claim 1 , wherein the control module comprises a valve.6. The flow modulator of claim 5 , wherein the control module is capable of adjusting the valve to at least an open position and a closed position.7. The flow modulator of claim 6 , wherein the control module is capable of adjusting the valve to an intermediate position.8. The flow modulator of claim 7 , ...

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Номер записи: 67
07-03-2019 дата публикации

FLUID HANDLING DEVICE AND METHOD OF HANDLING FLUIDS

Номер: US20190070607A1
Автор: CZILWIK Gregor, HUTZENLAUB Tobias, Keller Marc, Paust Nils
Принадлежит:

A fluid handling device has fluidic structures having inlet and outlet chambers and a connecting duct fluidically connecting the two. In a first state, the inlet chamber is completely or partly filled with at least a liquid and partly filled with a compressible medium, and the outlet chamber is at least partly filled with the compressible medium. One of the inlet chamber and the outlet chamber has such a venting duct that a flow resistance/volume product of venting of the chamber for the compressible medium amounts to at least 6700 N·s/m, the other of the inlet chamber and of the outlet chamber being vented. An actuator for actuating the fluidic structures is to cause a pressure difference of at least 30 Pa between the compressible media within the inlet and outlet chambers, so as to thereby switch a valve device implemented into the connecting duct. 2. Fluid handling device as claimed in claim 1 , wherein the flow resistance/volume product is a first flow resistance/volume product claim 1 , the other of the inlet chamber and of the outlet chamber comprising a venting duct and claim 1 , thus claim 1 , a second flow resistance/volume product of the venting of said chamber for the compressible medium claim 1 , the first flow resistance/volume product being at least four times larger than the second flow resistance/volume product.3. Fluid handling device as claimed in claim 1 , wherein the valve device is implemented in the connecting duct claim 1 , the valve device preventing claim 1 , in the first state claim 1 , liquid from getting from the inlet chamber into the outlet chamber.5. Fluid handling device as claimed in claim 4 , wherein the actuator is configured to cause heating of the compressible medium at a heating rate of ≥0.1 K/s.7. Fluid handling device as claimed in claim 6 , wherein the actuator is configured to cause cooling of the compressible medium at a cooling rate of ≥0.1 K/s.8. Fluid handling device as claimed in claim 5 , wherein the actuator is ...

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Номер записи: 68
05-03-2020 дата публикации

PNEUMATIC SYSTEM HAVING NOISE REDUCTION FEATURES FOR A MEDICAL FLUID MACHINE

Номер: US20200069856A1
Автор: Chapman Paul R., Childers Robert W., Hecht Gideon, Wellings Anders
Принадлежит:

A pneumatic system for a medical fluid machine operating a medical fluid cassette, the pneumatic system including an interface for supplying positive pneumatic pressure and negative pneumatic pressure to the medical fluid cassette; a source of positive pneumatic pressure; a source of negative pneumatic pressure; and a pneumatic pump including a first head and a second head, wherein the first head is dedicated to supplying positive pneumatic pressure to the positive pneumatic pressure source and the second head is dedicated to supplying negative pneumatic pressure to the negative pneumatic pressure source. 1. A pneumatic system for a medical fluid machine operating a medical fluid cassette , the pneumatic system comprising:an interface for supplying positive pneumatic pressure and negative pneumatic pressure to the medical fluid cassette;a source of positive pneumatic pressure;a source of negative pneumatic pressure; anda pneumatic pump including a first head and a second head, wherein the first head is dedicated to supplying positive pneumatic pressure to the positive pneumatic pressure source and the second head is dedicated to supplying negative pneumatic pressure to the negative pneumatic pressure source.2. The pneumatic system of claim 1 , which is configured to supply positive pneumatic pressure from the first head to the positive pneumatic pressure source and negative pressure from the second head to the negative pneumatic pressure source simultaneously.3. The pneumatic system of claim 1 , which includes a valve manifold assembly communicating pneumatically between the sources of positive and negative pneumatic pressure and the medical fluid cassette interface.4. The pneumatic system of claim 3 , wherein at least one of the positive pneumatic pressure source claim 3 , the negative pneumatic pressure source claim 3 , or the pneumatic pump is mounted to the valve manifold assembly.5. The pneumatic system of claim 1 , wherein the interface includes a machine ...

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Номер записи: 69
05-03-2020 дата публикации

LOW ELASTICITY FILMS FOR MICROFLUIDIC USE

Номер: US20200070154A1
Автор: Battrell C. Frederick, Bragd Matthew Scott, Kay Justin L., Sprague Isaac
Принадлежит:

Microfluidic circuit elements, such as a microvalve, micropump or microvent, formed of a microcavity divided by a diaphragm web into a first subcavity bounded by a first internal wall and a second subcavity bounded by a second internal wall, where the diaphragm web is characterized as a thin film having a first state contacting the first internal wall and a second state contacting the second internal wall and exhibiting essentially no elasticity in moving between the first state and the second state, the thin film web having been stretched beyond its yield point before or during use are provided. The disclosed elements enable faster and more efficient cycling of the diaphragm in the microcavity and increases the diaphragm surface area. In a preferred embodiment, the microfluidic circuit element is pneumatically driven and controls the motion of fluids in a microassay device. 122-. (canceled)23. A micropump , said micropump comprising a cavity havingi) a first subcavity configured to receive a fluid;ii) a second subcavity configured to be reversibly pressurized;iii) a diaphragm interposed between and separating said first subcavity from said second subcavity; and,wherein said diaphragm is a polymeric thin film web having a yield point and is characterized by a permanently overstretched deformation of said web.24. The micropump of claim 23 , wherein said thin film web is a low density polyethylene/ethylene vinyl acetate/polyvinylidene chloride/ethylene vinyl acetate/low density polyethylene co-laminate film.25. The micropump of claim 23 , wherein said thin film is composed of polyethylene claim 23 , polyvinylidene chloride claim 23 , poly-ethylene vinyl acetate claim 23 , polyvinylchloride claim 23 , polypropylene claim 23 , polyolefin claim 23 , or a composite or a co-laminate thereof.26. The micropump of claim 23 , wherein said thin film web is a high density polyethylene claim 23 , polyethylene terephthalate claim 23 , a polycarbonate claim 23 , a polyimide claim ...

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Номер записи: 70
07-03-2019 дата публикации

Fluidic pump and latch gate

Номер: US20190072119A1
Автор: Garett Andrew Ochs
Принадлежит: Facebook Technologies LLC

A fluidic device comprises a first channel conduit, a valve apparatus, and an additional element adjacent to the first channel conduit. The first channel conduit transports fluid from a first fluid entrance to a fluid exit. In one embodiment, the additional element is a pump chamber that receives fluid from a second fluid entrance and pumps fluid into the first channel conduit in accordance with fluid pressure. Alternatively, the additional elements include a second channel conduit and a neck of the first channel conduit. The first channel conduit and the second channel conduit share a common wall. Fluid pressure in the first channel conduit controls a valve apparatus. The value apparatus controls a rate of fluid flow in the first channel conduit by deforming the common wall to change a cross-sectional area of the neck, which changes a rate of fluid flow in the second channel conduit.

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Номер записи: 71
24-03-2016 дата публикации

SPRING-LESS MULTI-POSITION MICRO-FLUIDIC VALVE ASSEMBLY

Номер: US20160082439A1
Автор: SERVIN Carl M.
Принадлежит:

A springless rotary shear that produces compression forces by utilizing the stiffness properties of polymer seals. The valve is designed to produce an effective spring load, with inherent sealing force, by deflecting polymer elements whose response depends on stiffness that is governed by each component's elastic modulus and geometry. A stator seal protrudes thousandths of an inch beyond a stator seal housing. When a stator is fastened down to the stator seal housing the clamping forces are transmitted to the stator seal, rotor seal, shaft adapter, bearings and housings, and the assembly is deflected to a flush position, resulting in a sealing force between the rotor and stator seal. The transmitted sealing force is as a function of the stiffness of each component and the protrusion distance of the stator seal above the mating surface prior to fastening the stator. 1. A spring-less micro-fluidic valve assembly comprising:a stator seal device defining a substantially planar stator face and an opposite, distal facing stator contact surface perimetrically defined by a contact surface perimeter, said stator seal device including at least two or more stator channels extending therethrough from said contact surface to corresponding stator ports at said stator face;a rotor seal device having a substantially planar rotor face defining one or more rotor channels and an opposite, proximally facing rotor contact surface;a relatively rigid actuator housing having an inner wall defining an axially extending receiving passage therethrough, said inner wall including distally facing housing bearing support surface;a shaft adapter configured for axial receipt in said receiving passage of the actuator housing, and defining a proximally facing adapter bearing support surface and a distally facing adapter contact surface configured for contact support of said rotor contact surface;a bearing assembly disposed between the housing bearing support surface and the adapter bearing support ...

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Номер записи: 72
23-03-2017 дата публикации

Systems and methods for detection and quantification of analytes

Номер: US20170080421A1
Автор: Ayub Khattak, Clinton Sever
Принадлежит: Cue Health Inc

Devices, systems, and methods for detecting molecules of interest within a collected sample are described herein. In certain embodiments, self-contained sample analysis systems are disclosed, which include a reusable reader component, a disposable cartridge component, and a disposable sample collection component. In some embodiments, the reader component communicates with a remote computing device for the digital transmission of test protocols and test results. In various disclosed embodiments, the systems, components, and methods are configured to identify the presence, absence, and/or quantity of particular nucleic acids, proteins, or other analytes of interest, for example, in order to test for the presence of one or more pathogens or contaminants in a sample.

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Номер записи: 73
23-03-2017 дата публикации

APPARATUS, SYSTEM AND METHOD FOR PERFORMING AUTOMATED CENTRIFUGAL SEPARATION

Номер: US20170080422A1
Автор: Etemad-Moghadam Cyrus, Leonard Stephen W., Maaskant Robert, Talebpour Samad, YASOTHARAN Sanjesh, ZAHN Alexander
Принадлежит:

Systems, methods and devices are provided for the automated centrifugal processing of samples. In some embodiments, an integrated fluidic processing cartridge is provided, in which a centrifugation chamber is fluidically interfaced, through a lateral surface thereof, with a microfluidic device, and wherein the integrated fluidic processing cartridge is configured to be inserted into a centrifuge for centrifugation. A cartridge interfacing assembly may be employed to interface with the integrated fluidic processing cartridge for performing various fluidic processing steps, such as controlling the flow of fluids into and out of the centrifugation chamber, and controlling the flow of fluids into the microfluidic device, and optionally for the further fluidic processing of fluids extracted to the microfluidic device. The integrated fluidic processing cartridge may include a supernatant chamber the extraction of a supernatant thereto, and a diluent chamber for diluting a suspension collected in the centrifugation chamber. 1. A method of performing centrifugal separation and microfluidic processing using an integrated fluidic processing cartridge; a macrofluidic centrifugation chamber, wherein a distal region of the macrofluidic centrifugation chamber is configured to collect a sediment under the application of centrifugal force;', 'a microfluidic device having an inner surface and an outer surface, wherein the inner surface is attached to a lateral surface of the macrofluidic centrifugation chamber, and wherein the microfluidic device comprises one or more fluidic components that are configured to be actuated through the outer surface;', 'wherein a sediment extraction port is provided within the macrofluidic centrifugation chamber and wherein the sediment extraction port is in fluid communication, through the lateral surface, with a sediment extraction channel of the microfluidic device for extraction of the sediment to the microfluidic device;, 'the integrated fluidic ...

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Номер записи: 74
22-03-2018 дата публикации

DIAPHRAGM CHECK VALVES AND METHODS OF MANUFACTURE THEREOF

Номер: US20180080578A1
Автор: Bouey Natasha Yvette, Chou Man Ting, Jiang Fukang, Li Po-Ying, Lotfi Atoosa, Pang Changlin, Tai Yu-Chong
Принадлежит:

Microscale valves for use in, e.g., micropump devices, may be formed of a slitted diaphragm bonded o the interior of a valve tube. A bump in the diaphragm and/or a backward-leakage stopper may increase the breakdown pressure of the valve. A push-rod may be used to pre-load the valve membrane to thereby increase the cracking pressure. 1. An in-line check valve comprising:a first tube defining a first lumen for flow of fluid therethrough;affixed to an interior surface of the first tube and spanning a cross-section thereof, an elastic diaphragm comprising a slit or opening therethrough; anda backward-leakage stopper (i) extending beyond and surrounding an inlet end of the first tube, (ii) affixed to an exterior surface of the first tube, and (iii) abutting the diaphragm at a first side thereof;wherein the valve is configured to (i) open upon application of at least a cracking pressure on the first side of the diaphragm so as to permit fluid to pass through the slit or opening from the first side to a second side of the diaphragm, and (ii) prevent backflow of fluid from the second side to the first side until at least a breakdown pressure is reached on the second side.2. The check valve of claim 1 , wherein a diameter of the first tube is less than 1 mm.3. The check valve of claim 1 , wherein a largest dimension of the valve is less than 1 mm.4. The check valve of claim 1 , wherein the elastic diaphragm extends into a skirt secured to the interior surface of the first tube.5. The check valve of claim 4 , wherein the first tube includes holes through a side wall thereof in regions adjacent the skirt.6. The check valve of claim 5 , wherein the skirt is secured to the first tube by epoxy extending through the holes.7. The check valve of claim 1 , wherein the diaphragm comprises a convex bump on the first side claim 1 , the slit being co-located with the bump.8. The check valve of claim 1 , wherein the slit or opening is configured to flex and open upon application of at ...

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Номер записи: 75
31-03-2022 дата публикации

Instrument systems for integrated sample processing

Номер: US20220097045A1
Автор: Benjamin Hindson, Donald A. Masquelier, Kevin Ness, Rajiv Bharadwaj
Принадлежит: 10X Genomics Inc

An integrated system for processing and preparing samples for analysis may include a microfluidic device including a plurality of parallel channel networks for partitioning the samples including various fluids, and connected to a plurality of inlet and outlet reservoirs, at least a portion of the fluids comprising reagents, a holder including a closeable lid hingedly coupled thereto, in which in a closed configuration, the lid secures the microfluidic device in the holder, and in an open configuration, the lid is a stand orienting the microfluidic device at a desired angle to facilitate recovery of partitions or droplets from the partitioned samples generated within the microfluidic device, and an instrument configured to receive the holder and apply a pressure differential between the plurality of inlet and outlet reservoirs to drive fluid movement within the channel networks.

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Номер записи: 76
31-03-2022 дата публикации

MINIATURE FLUID TRANSPORTATION DEVICE

Номер: US20220099084A1
Автор: CHEN SHIH-CHANG, Han Yung-Lung, Huang Chi-Feng, Jhang Jyun-Yi, Kao Chung-Wei, Lee Wei-Ming, Mou Hao-Jan, Tsai Chang-Yen, Yang Chi-Chang
Принадлежит: Microjet Technology Co., Ltd.

A miniature fluid transportation device is provided and includes a convergence component, a valve component, an outlet plate and a plurality of fluid transportation actuation components. The plurality of fluid transportation actuation components are disposed on the convergence component so as to transport the fluid to the convergence component. The convergence component guides the fluid transported by the fluid transportation actuation components to the outlet plate through the valve component. The outlet plate guides the fluid from different transportation actuation components back to the convergence component by a separation guiding block. The fluid is converged in a convergence central slot of the convergence component and is discharged out through a collection channel of the outlet plate. Consequently, the problem of interference owing to the convergence of the fluid transported by different fluid transportation actuation components can be avoided. 1. A miniature fluid transportation device , comprising:a convergence component comprising a plurality of carrying regions, a plurality of convergence passages, a plurality of convergence slots, a convergence central slot, a communication slot and a convergence side slot, wherein the plurality of carrying regions are corresponding in position to and in fluid communication with the plurality of convergence passages one-to-one, a convex element is disposed in the convergence passage, the plurality of convergence slots are in fluid communication with the convergence central slot through the communication slot, a convergence convex is disposed at a center of the convergence central slot, and one side of the convergence central slot is extended and in fluid communication with the convergence side slot;a valve component stacked on the convergence component and comprising a plurality of passage valve regions, a plurality of convergence-slot valve regions, a convergence-central-slot valve region and a through side slot, ...

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Номер записи: 77
25-03-2021 дата публикации

Micro-valve

Номер: US20210088155A1
Автор: Ayaka Sato, Kazunori Takahashi, Shigeaki Shibamoto, Wenjian LU
Принадлежит: Shimadzu Corp

Provided is a micro-valve having a laminate structure capable of improving sealing performance when a foreign substance is mixed. The micro-valve 10 has a laminate structure and includes a base layer 20 and a diaphragm layer 30. The base layer is formed with an inlet port 23 for introducing a gas into the micro-valve and an outlet port for allowing the gas to flow outside. The diaphragm layer is arranged to face the base layer. The diaphragm layer switches the flowing and blocking of the gas from the inlet port to the outlet port by elastic deformation thereof. The diaphragm layer has a configuration in which a plurality of deformation regions 33 and a plurality of rigid body regions 34 are alternately formed, the deformation region being elastically deformable in accordance with an inflow of a pneumatic fluid into the micro-valve. The diaphragm layer closes at least one of the inlet port and the outlet port by elastic deformation of at least a part of the plurality of deformation regions.

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Номер записи: 78
21-03-2019 дата публикации

Apparatus, System, And Method Using Immiscible-Fluid-Discrete-Volumes

Номер: US20190085387A1
Автор: Cox David M., Lee Linda G., Ma Congcong, Oldham Mark F., REEL Richard T., SCHROEDER Benjamin G., SORENSON Jon M., WIYATNO Willy, WOO Sam L.
Принадлежит:

Various embodiments of the teachings relate to a system or method for sample preparation or analysis in biochemical or molecular biology procedures. The sample preparation can involve small volume processed in discrete portions or segments or slugs, herein referred to as discrete volumes. A molecular biology procedure can be nucleic acid analysis. Nucleic acid analysis can be an integrated DNA amplification/DNA sequencing procedure. 1. A method comprising:amplifying a nucleic acid in at least one conduit to form an amplicon, the at least one conduit comprising an inner wall;attaching the amplicon to the inner wall to form an attached amplicon; anddetecting the attached amplicon or an attached derivative thereof, in the at least one conduit.2. A method comprising:sequentially contacting an aqueous sample fluid in a conduit with a non-aqueous spacing fluid that is immiscible with the aqueous sample, to form a plurality of discrete volumes of the aqueous sample fluid separated from one another by the non-aqueous spacing fluid, the aqueous sample fluid comprising a plurality of target nucleic acid sequences, wherein at least one of the discrete volumes contains at least one target nucleic acid sequence;amplifying the at least one target nucleic acid in the conduit to form an amplicon; andsubjecting the amplicon to a nucleic acid sequencing reaction in the conduit.3. The method of claim 2 , wherein subjecting the nucleic acid sequence to a sequencing reaction forms a detectable product claim 2 , and the method further comprises detecting the detectable product.4. The method of claim 3 , wherein the detectable product is detected inside the conduit.5. The method of claim 3 , wherein the detectable product is detected with a flow cell.6. The method of claim 2 , wherein the sequencing reaction comprises a Sanger sequencing reaction.7. The method of claim 2 , further comprising dividing the at least on nucleic acid containing discrete volume into two or more portions before ...

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Номер записи: 79
02-04-2015 дата публикации

Particle manipulation system with out-of plane channel

Номер: US20150093817A1
Автор: John S. Foster, Kamala R. Qalandar, Kevin E. Shields, Kimberly L. Turner, Nicholas C. MARTINEZ, Stefan Miltenyi
Принадлежит: Owl biomedical Inc

A particle manipulation system uses a MEMS-based, microfabricated particle manipulation device which has an inlet channel, output channels, and a movable member formed on a substrate. The movable member moves parallel to the fabrication plane, as does fluid flowing in the inlet channel. The movable member separates a target particle from the rest of the particles, diverting it into an output channel. However, at least one output channel is not parallel to the fabrication plane. The device may be used to separate a target particle from non-target material in a sample stream. The target particle may be, for example, a stem cell, zygote, a cancer cell, a T-cell, a component of blood, bacteria or DNA sample, for example. The particle manipulation system may also include a microfluidic structure which focuses the target particles in a particular portion of the inlet channel.

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Номер записи: 80
31-03-2016 дата публикации

Systems and methods for detection and quantification of analytes

Номер: US20160091518A1
Автор: Ayub Khattak, Clinton Sever
Принадлежит: Cue Health Inc

Devices, systems, and methods for detecting molecules of interest within a collected sample are described herein. In certain embodiments, self-contained sample analysis systems are disclosed, which include a reusable reader component, a disposable cartridge component, and a disposable sample collection component. In some embodiments, the reader component communicates with a remote computing device for the digital transmission of test protocols and test results. In various disclosed embodiments, the systems, components, and methods are configured to identify the presence, absence, and/or quantity of particular nucleic acids, proteins, or other analytes of interest, for example, in order to test for the presence of one or more pathogens or contaminants in a sample.

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Номер записи: 81
21-03-2019 дата публикации

Gas transportation device

Номер: US20190085836A1
Автор: Chang-Yen Tsai, Chi-Feng Huang, Hao-Jan Mou, Wei-Ming Lee, Yung-Lung Han
Принадлежит: Microjet Technology Co Ltd

A gas transportation device is provided and includes a first flow guiding unit and a second flow guiding unit, each of which includes an inlet and an outlet. While the first flow guiding unit and the second flow guiding unit are actuated, gas is inhaled through the respective inlets and discharged out through the respective outlets. A gas-collection chamber is disposed between the first flow guiding unit and the second flow guiding unit and includes a discharging opening. The gas is inhaled through the inlets of the first flow guiding unit and the second flow guiding unit, and transported to the gas-collection chamber through the outlets thereof. The gas in the gas-collection chamber is discharged out through the outlets of the first flow guiding unit and the second flow guiding unit, to achieve an adjustment of gas transportation amount.

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Номер записи: 82
21-03-2019 дата публикации

Gas transportation device

Номер: US20190085995A1
Автор: Chang-Yen Tsai, Chi-Feng Huang, Hao-Jan Mou, Hsuan-Kai Chen, Yung-Lung Han
Принадлежит: Microjet Technology Co Ltd

A gas transportation device includes an inlet plate, a substrate, a resonance plate, an actuating plate, a piezoelectric component and an outlet plate stacked sequentially. The gas transportation device includes a valve disposed within at least one of the inlet of the inlet plate and the outlet of the outlet plate. A first chamber is formed between the resonance plate and the actuating plate, and a second chamber is formed between the actuating plate and the outlet plate. When the piezoelectric component drives the actuating plate, a pressure gradient is formed between the first and second chambers and the valve is opened. Accordingly, gas is inhaled into the convergence chamber via the inlet, transported into the first chamber through a central aperture of the resonance plate, transported into the second chamber through a vacant space of the actuating plate, and then discharged out from the outlet, so as to transport the gas.

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Номер записи: 83
05-05-2022 дата публикации

MICROFLUIDIC SYSTEM FOR AMPLIFYING AND DETECTING POLYNUCLEOTIDES IN PARALLEL

Номер: US20220136034A1
Автор: Brahmasandra Sundaresh N., Ganesan Karthik, Handique Kalyan, Williams Jeff
Принадлежит:

The present technology provides for an apparatus for detecting polynucleotides in samples, particularly from biological samples. The technology more particularly relates to microfluidic systems that carry out PCR on nucleotides of interest within microfluidic channels, and detect those nucleotides. The apparatus includes a microfluidic cartridge that is configured to accept a plurality of samples, and which can carry out PCR on each sample individually, or a group of, or all of the plurality of samples simultaneously.

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Номер записи: 84
05-05-2022 дата публикации

PASSIVE MICROFLUIDIC VALVES

Номер: US20220136618A1
Автор: King Natalie, LIN Keng-Yu, Wehner Michael
Принадлежит:

A passive microfluidic valve includes a first manifold portion having a first chamber; a first inlet fluidly coupled to the first chamber; and a second inlet. The valve also includes a second manifold portion in fluid communication with the first chamber via a channel. The second manifold portion includes a second chamber fluidly coupled to the first chamber and the second inlet. The valve further includes a flexible membrane disposed between the first manifold portion and the second manifold portion and separating the first chamber and the second chamber, the flexible membrane configured to modulate a flow rate of a media flowing between the first inlet and the second inlet in either direction in response to pressure of the media flow.

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Номер записи: 85
19-03-2020 дата публикации

Methods for Controlling Fluid Flow in a Microfluidic System

Номер: US20200086319A1
Автор: Bohm Sebastian, Deshpande Manish, Gilbert John R.
Принадлежит:

A microfluidic device includes a microchannel having an interior bounded by a side wall, an inlet, a switching region, and a plurality of outlet channels downstream of the switching region. The microchannel is formed in a microfluidic chip substrate and configured to accommodate a flow of liquid through the microchannel. The microfluidic device includes a valve operatively coupled to the switching region comprising a sealed reservoir. A side passage extends between the reservoir and the interior of the microchannel via an aperture in the side wall and is configured to accommodate a volume of liquid between the interior of the microchannel and the reservoir. The microfluidic device includes an actuator integrated into the microfluidic chip and configured to increase an internal pressure of the reservoir and move at least a portion of the volume of the liquid from the side passage into the microchannel to deflect a portion of the liquid flowing through the microchannel. 1. (canceled)2. A method for controlling liquid flow in a microfluidic device , comprising:flowing a liquid through a microchannel formed in a microfluidic chip substrate, the microchannel having an interior bounded by a side wall, an inlet, a switching region, and a plurality of outlet channels downstream of the switching region; andactuating a valve operatively coupled to the switching region, the valve including a sealed reservoir and a side passage extending between the sealed reservoir and the interior of the microchannel via an aperture in the side wall,whereby actuating the valve increases or decreases an internal pressure of the sealed reservoir to cause a momentary flow disruption in the microchannel to deflect the liquid flowing therein.3. The method of claim 2 , wherein actuating the valve includes using an actuator integrated in the microfluidic chip.4. The method of claim 2 , wherein actuating the valve includes using an actuator operatively coupled with the microfluidic chip.5. The method ...

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Номер записи: 86
28-03-2019 дата публикации

COMPOUNDING DEVICE, SYSTEM, KIT, SOFTWARE, AND METHOD

Номер: US20190091639A1
Автор: Brown Michael Y., Lane Benjamin R., Mumpower Mariano
Принадлежит:

An exemplary compounding system and device for mixing materials can include a housing, a first material source and a second material source. A first fluid line can be operationally connected to the housing and configured to transport a first volume of fluid per unit time from the first material source to a final container. A second fluid line can be operationally connected to the housing and configured to transport a second volume of fluid per unit time from the second material source to the final container. The device can also include a pump system including, a first pump having a first rotor and a first platen which secures the first fluid line between the first rotor and the first platen, the first pump being configured to move the first volume of fluid through the first fluid line, and a second pump having a second rotor and a second platen which secures the second fluid line between the second rotor and the second platen, the second pump being configured to move the second volume of fluid through the second fluid line. A first platen lock can be provided and can be rotated in a first direction to lock the first platen in a closed position relative to the first rotor, and wherein rotation of the first rotor draws the first material source through the first fluid line. The pump system can also be configured such that the volume of fluid per unit time delivered by the first and second pumps is different, and/or where the first and second pumps have different head characteristics. 1. A compounding device for mixing materials , comprising:a housing;a first material source and a second material source, the first material source being distinct from the second material source;a first fluid line operationally connected to the housing and configured to transport a first volume of fluid per unit time from the first material source to a final container;a second fluid line operationally connected to the housing and configured to transport a second volume of fluid per unit ...

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Номер записи: 87
05-04-2018 дата публикации

AMPLIFICATION OF BIOLOGICAL TARGETS VIA ON-CHIP CULTURE FOR BIOSENSING

Номер: US20180095083A1
Автор: Arndt William, Carson Bryan, Edwards Thayne L., Finley Melissa, Harper Jason C.
Принадлежит:

The present invention, in part, relates to methods and apparatuses for on-chip amplification and/or detection of various targets, including biological targets and any amplifiable targets. In some examples, the microculture apparatus includes a single-use, normally-closed fluidic valve that is initially maintained in the closed position by a valve element bonded to an adhesive coating. The valve is opened using a magnetic force. The valve element includes a magnetic material or metal. Such apparatuses and methods are useful for in-field or real-time detection of targets, especially in limited resource settings. 1. A method for amplifying a target in a sample , the method comprising:introducing the sample within a first reservoir of a first apparatus, wherein the first apparatus comprises a first outlet in fluidic communication with the first reservoir, and wherein the first apparatus is configured to allow for in-field or real-time amplification of the target; andincubating the sample within the first reservoir, thereby amplifying the target within the sample and providing an amplified sample.2. The method of claim 1 , further comprising sterilizing the amplified sample during or after the incubation step.3. The method of claim 1 , wherein the first apparatus further comprises a first valve element claim 1 , and a first valve seat conformed to support the first valve element in a position that closes the first outlet.4. The method of claim 3 , further comprising opening the first outlet by applying a magnetic field to the first valve element adhesively bonded to the first valve seat so as to produce a magnetic force configured to detach the first valve element from the first valve seat.5. The method of claim 1 , further comprising introducing the amplified sample within an assay chamber claim 1 , wherein the first outlet leads to the assay chamber and the assay chamber is configured to include one or more detection agents for identifying the target claim 1 , thereby ...

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Номер записи: 88
06-04-2017 дата публикации

Three-Way Microvalve device and method of fabrication

Номер: US20170097108A1
Автор: Huff Michael A.
Принадлежит:

A three-way (3-way) Micro-Electro-Mechanical Systems (MEMS)-based micro-valve device and method of fabrication for the implementation of a three-way MEMS-based micro-valve are disclosed. The micro-valve device has a wide range of applications, including medical, industrial control, aerospace, automotive, consumer electronics and products, as well as any application(s) requiring the use of three-way micro-valves for the control of fluids. The discloses three-way micro-valve device and method of fabrication that can be tailored to the requirements of a wide range of applications and fluid types, and can also use a number of different actuation methods, including actuation methods that have very small actuation pressures and energy densities even at higher fluidic pressures. This is enabled by a novel pressure-balancing scheme, wherein the fluid pressure balances the actuator mechanism so that only a small amount of actuation pressure (or force) is needed to switch the state of the actuator and device from open to closed, or closed to open. 1. A three-way micro-valve device comprising:a fluid chamber,at least one fluidic port,a movable membrane positioned within the fluid chamber,the movable membrane being electrically actuatable so as to open and close the at least one fluidic port to the flow of fluids through the micro-valve.2. The micro-valve of claim 1 , wherein the movable membrane is positioned near a center of the fluid chamber.3. The micro-valve of claim 2 , forces acting on the movable membrane caused by the fluid are balanced or nearly balanced on both sides of the membrane by pressure within the fluid chamber caused by the fluid.4. The micro-valve of claim 1 , wherein electrostatic actuation is used to move the movable membrane.5. The micro-valve of claim 1 , wherein piezoelectric actuation is used to move the movable membrane.6. The micro-valve of claim 1 , wherein either bimetallic actuation claim 1 , shape-memory alloy actuation claim 1 , or thermo- ...

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Номер записи: 89
06-04-2017 дата публикации

Automated pipetting apparatus having a combined liquid pump and pipette head system

Номер: US20170097373A1
Автор: Jeff Williams, Kerry Wilson
Принадлежит: HandyLab Inc

The technology described herein generally relates to systems for extracting polynucleotides from multiple samples, particularly from biological samples, and additionally to systems that subsequently amplify and detect the extracted polynucleotides. The technology more particularly relates to microfluidic systems that carry out PCR on multiple samples of nucleotides of interest within microfluidic channels, and detect those nucleotides. The technology still more particularly relates to automated devices for carrying out pipetting operations, particularly on samples in parallel, consistent with sample preparation and delivery of PCR-ready nucleotide extracts to a cartridge wherein PCR is run.

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Номер записи: 90
26-03-2020 дата публикации

INTEGRATED APPARATUS FOR PERFORMING NUCLEIC ACID EXTRACTION AND DIAGNOSTIC TESTING ON MULTIPLE BIOLOGICAL SAMPLES

Номер: US20200094253A1
Автор: Handique Kalyan, Williams Jeff, WILSON Kerry
Принадлежит:

The technology described herein generally relates to systems for extracting polynucleotides from multiple samples, particularly from biological samples, and additionally to systems that subsequently amplify and detect the extracted polynucleotides. The technology more particularly relates to microfluidic systems that carry out PCR on multiple samples of nucleotides of interest within microfluidic channels, and detect those nucleotides. 1. (canceled)2. A system for analyzing a plurality of nucleic acid-containing samples , the system comprising:a first module configured to extract nucleic acids from the plurality of nucleic acid-containing samples, a bay configured to removably receive a housing comprising a plurality of process chambers that are maintained at a same height relative to one another as the housing is received in and removed from the bay, the plurality of process chambers aligned along a first axis when the housing is received in the bay, the bay comprising one or more complementary registration members configured to receive the housing in a single orientation when the housing is received in the bay,', 'the first module further comprising a magnetic separator positioned to apply a magnetic force to a first side of the plurality of process chambers when the housing is received in the bay, the magnetic separator comprising one or more magnets aligned along a second axis parallel to the first axis when the housing is received in the bay, the one or more complementary registration members further configured to align the plurality of process chambers with the magnetic separator when the housing is received in the bay, and', 'the first module further comprising a heating assembly positioned adjacent to a second side of the plurality of process chambers opposite the first side when the housing is received in the bay, the heater assembly comprising one or more heaters aligned along a third axis parallel to the first axis when the housing is received in the bay, ...

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Номер записи: 91
26-03-2020 дата публикации

Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples

Номер: US20200094254A1
Автор: Jeff Williams, Kalyan Handique, Kerry Wilson
Принадлежит: HandyLab Inc

The technology described herein generally relates to systems for extracting polynucleotides from multiple samples, particularly from biological samples, and additionally to systems that subsequently amplify and detect the extracted polynucleotides. The technology more particularly relates to microfluidic systems that carry out PCR on multiple samples of nucleotides of interest within microfluidic channels, and detect those nucleotides.

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Номер записи: 92
12-04-2018 дата публикации

ANALYSIS SYSTEM FOR TESTING A SAMPLE

Номер: US20180099278A1
Автор: Niemeyer Axel, SCHMOLKE Hannah
Принадлежит: BOEHRINGER INGELHEIM VETMEDICA GMBH

An analysis system for testing a biological sample wherein a sensor cover can be or is pneumatically lowered onto a sensor apparatus in order to detect an analyte of the sample. 1. An analysis system for testing a biological sample ,the analysis system comprising a main body having a plurality of channels, and comprising a sensor arrangement for detecting an analyte of the sample, 'wherein, at least one of:', 'the sensor arrangement comprising a sensor apparatus having capture molecules and a sensor cover that is flexible at least in part for covering the sensor apparatus, the sensor cover being lowerable onto or towards the sensor apparatus in an actuated state,'}in an unactuated state, the sensor cover is at least substantially planar or flat on a side facing the sensor apparatus and has a raised portion in a center on a side remote or opposite from the sensor apparatus, andthe sensor cover is held at the main body, the sensor cover being held at an edge in a depression or receptacle of the main body.2. The analysis system according to claim 1 , wherein the sensor cover is lowered pneumatically.3. The analysis system according to claim 1 , wherein the sensor apparatus is pressed or sealed against the sensor cover in an edge region.4. The analysis system according to claim 1 , characterized in that a housing of the sensor apparatus is sealingly mounted on the sensor cover in an edge region claim 1 , the housing surrounding a chip or support at least partially.5. The analysis system according to claim 4 , wherein the chip or support is integrally cast in the housing.6. The analysis system according to claim 4 , wherein the housing leaves a sensor array of the chip or support free on the measuring side.7. The analysis system according to claim 4 , wherein the sensor apparatus comprises a plurality of electrical contacts or contact surfaces.8. The analysis system according to claim 1 , further comprising a pneumatic connection claim 1 , by means of which at least one ...

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Номер записи: 93
12-04-2018 дата публикации

ELECTROLYTIC MEMBRANE VALVE

Номер: US20180100601A1
Автор: Aguirre Gerson R., Feyssa Belachew
Принадлежит:

An electrolytic membrane valve and method of its manufacture are provided. The valve includes a substrate comprising an opening and a conductive membrane impermeable to a conductive media and sealing the opening, as well as a cathode on the substrate and in communication with the membrane through the conductive media, and an anode on the substrate directly contacting the membrane. The anode is at least partially protected from electrochemical corrosion, and upon application of an electrical potential between the anode and the cathode, the membrane ruptures to allow flow of the conductive media through the opening. 1. An electrolytic valve comprising:a substrate comprising an opening;a conductive membrane impermeable to a conductive media and sealing the opening;a cathode on the substrate and in communication with the membrane through the conductive media;an anode on the substrate and directly contacting the membrane;wherein the anode is at least partially protected from electrochemical corrosion; andwherein upon application of an electrical potential between the anode and the cathode, the membrane ruptures to allow flow of the conductive media through the opening.2. The electrolytic valve of claim 1 , wherein either of the anode or cathode are printed onto the substrate.3. The electrolytic valve of claim 1 , wherein the anode comprises a carbon-based ink comprising a conductive material.4. The electrolytic valve of claim 2 , wherein the anode is printed onto the substrate such that the anode partially overlaps the membrane and physically holds the membrane against a surface of the substrate and over the opening.5. The electrolytic valve of claim 1 , wherein the anode overlaps the membrane around a perimeter of the membrane.6. The electrolytic valve of claim 1 , wherein at least a portion of the cathode arcs circumferentially around an axis defined by a center point of the membrane.7. The electrolytic valve of claim 4 , wherein the substrate is flexible claim 4 , and ...

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Номер записи: 94
23-04-2015 дата публикации

Microdevice structure of microchannel chip

Номер: US20150107709A1
Автор: Xingyue Peng
Принадлежит: Xingyue Peng

A microdevice structure of microchannel chip is provided which includes one gas channel and at least one liquid channel. The microchannel connects the gas channel and each liquid channel. The most basic microdevice of the mirochannel chip comprises micropressure sensor, microvalve, micropiston and micropump which are controlled by digital pressure gas microcircuit in the chip. Each microdevice isolates the gas phase and liquid phase by microhole without any movable component and any special ventilate or elastic material. The gas-liquid interface is driven by the pressure difference of gas phase and liquid phase to enable the microdevice to implement the functions, such as sensing pressure, switching fluid channel, transporting liquid effectively, and so on. All kinds of microdevices can be shaped on the hard material (for example glass) by etching, so as to integrate a great lot microdevices with low cost, and the structure of chip and these several microdevices can be formed by adopting other methods on other material.

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Номер записи: 95
04-04-2019 дата публикации

FLUID SYSTEM

Номер: US20190101111A1
Автор: CHEN Hsuan-Kai, Han Yung-Lung, Huang Chi-Feng, Mou Hao-Jan
Принадлежит: Microjet Technology Co., Ltd.

A fluid system includes a fluid actuating region, a fluid channel, a convergence chamber, a sensor and a plurality of valves. The fluid actuating region includes one or a plurality of fluid-guiding units. Each of the fluid-guiding units includes an inlet plate, a substrate, a resonance plate, an actuating plate, a piezoelectric member and an outlet plate, which are stacked sequentially. When the piezoelectric member drives the actuating plate to undergo a bending vibration in resonance, the fluid is transported into the fluid-guiding units and is pressurized to be discharged out. The fluid channel has a plurality of branch channels for splitting the fluid transported in the fluid actuating region. The convergence chamber is in communication with the fluid channel. The sensor is disposed in the fluid channel for measuring the fluid within the fluid channel. 1. A fluid system , produced by an integrated method , and comprising:a fluid actuating region including at least one fluid-guiding unit, wherein the at least one fluid-guiding unit includes:an inlet plate having at least one inlet aperture;a substrate;a resonance plate having a central aperture, wherein a first chamber is formed between the resonance plate and the inlet plate;an actuating plate having a suspension part, an outer frame part and at least one interspace;a piezoelectric member attached on a surface of the suspension part of the actuating plate; andan outlet plate having an outlet aperture,wherein the inlet plate, the substrate, the resonance plate, the actuating plate and the outlet plate are stacked sequentially, a gap formed between the resonance plate and the actuating plate is defined as a second chamber, and a third chamber is formed between the actuating plate and the outlet plate, wherein while the piezoelectric member drives the actuating plate to undergo a bending vibration in resonance, a pressure difference is formed between the second chamber and the third chamber so that fluid is inhaled ...

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Номер записи: 96
04-04-2019 дата публикации

FLUID SYSTEM

Номер: US20190101938A1
Автор: CHEN SHIH-CHANG, Huang Che-Wei, Huang Chi-Feng, Liao Jia-Yu, MO Li-Pang, Mou Hao-Jan
Принадлежит: Microjet Technology Co., Ltd.

A fluid system includes a fluid active region, a fluid channel, a convergence chamber and plural valves. The fluid active region includes at least one fluid-guiding unit. The fluid-guiding unit is enabled under control to transport fluid to be discharged out through the outlet aperture. The fluid channel is in communication with the outlet aperture of the fluid active region, and has plural branch channels to split the fluid discharged from the fluid active region. The convergence chamber is in communication with the fluid channel. The valves each of which is disposed in the corresponding branch channel, wherein the fluid is discharged out through the branch channels according to opened/closed states of the valves under control. The fluid system of the present disclosure is capable of acquiring required flow rate, pressure and amount of the fluid to be transported. 1. A fluid system , produced by an integrated method , the fluid system comprising:a fluid active region comprising at least one fluid-guiding unit, wherein the fluid-guiding unit is enabled under control to transport fluid to be discharged out through at least one outlet aperture;a fluid channel in communication with the at least one outlet aperture of the fluid active region, and having plural branch channels to split the fluid discharged from the fluid active region, so that a specific required amount of the fluid to be transported is determined;a convergence chamber in communication with the fluid channel and disposed for allowing the fluid to be accumulated therein; anda plurality of valves each of which disposed in the corresponding branch channel, wherein the fluid is discharged out through the branch channels according to opened/closed states of the valves under control.2. The fluid system according to claim 1 , wherein the at least one fluid-guiding unit of the fluid active region comprises plural fluid-guiding units claim 1 , and the plural fluid-guiding units are connected with each other and ...

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Номер записи: 97
19-04-2018 дата публикации

REACTION CIRCUIT DESIGN IN MICROFLUIDIC CIRCUITS

Номер: US20180104690A1
Автор: BLAINEY Paul, Hoang Son, KIM SOOHONG, Nolan Jillian, Zhang Huaibin (Eli)
Принадлежит:

The microfluidic devices and systems disclosed herein reduce sample loss and help decrease sample processing bottlenecks for applications such as next generation sequencing (NGS). The microfluidic devices include a plurality of reaction modules. Each reaction module may comprise one or more reaction circuits. Each reaction circuit may comprise a single reaction flow channel with each reaction circuit connected by a bridge flow channel. Alternatively, each reaction circuit may comprise two or more reaction flow channels connected by two or more bridge flow channels. The combination of any two bridge flow channels and a portion of the two or more reaction flow channels between the any two bridge flow channels defining may define the reaction circuit. The reaction module may be arranged as nodes connected by bridge flow channels or each reaction module may be arranged in a parallel fashion on the microfluidic device. 1. A microfluidic device comprising a plurality of reaction modules , each reaction module comprising one or more reaction circuits , each reaction circuit comprising at least one reaction flow channel connected to at least one bridge flow channel.2. The microfluidic device of claim 1 , wherein each reaction module comprises a first reaction flow channel connected at a first end to a first input and connected at a second end to a second input claim 1 , and the second flow channel connected at a first end to an output claim 1 , and wherein the first and second reaction flow channels are connected by three or more bridge flow channels claim 1 , wherein any two bridge flow channels and a portion of the first reaction flow channel and second reaction flow channel located between the any two bridge flow channels define a single reaction circuit.3. The microfluidic device of claim 1 , wherein the first reaction flow channel claim 1 , the second reaction flow channel claim 1 , and each bridge flow channel comprises one or more valves that can be sequentially ...

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Номер записи: 98
26-04-2018 дата публикации

VALVE

Номер: US20180111384A1
Автор: FISHER Gil
Принадлежит: HP INDIGO B.V.

A valve comprises an orifice plate () having one or more orifices () through which a fluid may flow, and one or more piezo-electric elements (). Each element () has a face positioned to contact the orifice plate at an orifice. Each element has a first state in which it abuts the plate to prevent flow of fluid through the associated orifice and a second state in which the face is spaced from the plate to allow flow through the associated orifice. A controller () selectively applies a first voltage to an elements to cause it to adopt the first state and applies a second voltage to the one or more elements to cause the elements to adopt the second state. 1. A printer comprising:a fluid source comprising a nozzle to eject drops from the fluid source;a gas jet along a path of drops ejected from the nozzle;a valve comprising a piezo electric device to block and unblock the gas jet;a controller to selectively operate the valve to deflect some drops ejected from the nozzle out of the path with the gas jet and to allow other drops ejected from the nozzle to follow the path to a print medium, wherein drops are selectively deflected or allowed to reach the print medium in accordance with data from a host device defining an image to be printed.2. The printer of claim 1 , wherein:the gas jet comprises an orifice in an orifice plate, the orifice directing a flow of gas under pressure into the path of drops; andthe piezo electric device of the valve moves linearly in a direction perpendicular to the orifice plate to selectively block or unblock the orifice to the flow of gas.3. The printer of claim 1 , further comprising a gutter to collect drops deflected from the path by the gas jet.4. The printer of claim 3 , further comprising a recirculating system to return drops from the gutter to the fluid source.5. The printer of claim 1 , further comprising a vibrator to eject drops from the fluid source via the nozzle.6. The printer of claim 1 , wherein:the fluid source comprises an ...

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Номер записи: 99
13-05-2021 дата публикации

Microfluidic system for amplifying and detecting polynucleotides in parallel

Номер: US20210139951A1
Автор: Jeff Williams, Kalyan Handique, Karthik Ganesan, Sundaresh N. Brahmasandra
Принадлежит: HandyLab Inc

The present technology provides for an apparatus for detecting polynucleotides in samples, particularly from biological samples. The technology more particularly relates to microfluidic systems that carry out PCR on nucleotides of interest within microfluidic channels, and detect those nucleotides. The apparatus includes a microfluidic cartridge that is configured to accept a plurality of samples, and which can carry out PCR on each sample individually, or a group of, or all of the plurality of samples simultaneously.

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Номер записи: 100