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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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Поддерживает ввод нескольких поисковых фраз (по одной на строку). При поиске обеспечивает поддержку морфологии русского и английского языка
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Применить Всего найдено 3498. Отображено 100.
19-01-2012 дата публикации

Microfluidic system including a bubble valve for regulating fluid flow through a microchannel

Номер: US20120015442A1
Автор: John Richard Gilbert, Manish Deshpande, Sebastian Böhm
Принадлежит: Cytonome ST LLC

A microfluidic system includes a bubble valve for regulating fluid flow through a microchannel. The bubble valve includes a fluid meniscus interfacing the microchannel interior and an actuator for deflecting the membrane into the microchannel interior to regulate fluid flow. The actuator generates a gas bubble in a liquid in the microchannel when a sufficient pressure is generated on the membrane.

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Номер записи: 1
29-03-2012 дата публикации

Thermal Microvalves

Номер: US20120077231A1
Автор: Brian N. Johnson, Mark A. Burns, Michael Chen
Принадлежит: University of Michigan

The movement and mixing of microdroplets through microchannels is described employing silicon-based microscale devices, comprising microdroplet transport channels, reaction regions, electrophoresis modules, and radiation detectors. The discrete droplets are differentially heated and propelled through etched channels. Electronic components are fabricated on the same substrate material, allowing sensors and controlling circuitry to be incorporated in the same device.

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Номер записи: 2
19-04-2012 дата публикации

Valve for lab-on-a-chip systems, method for actuating and for producing valve

Номер: US20120090692A1
Автор: Katja Friedrich, Peter Paulicka, Walter Gumbrecht
Принадлежит: SIEMENS AG

A substrate of a lab-on-a-chip system has two adjacent recesses, one serving as a flow channel and the other one being filled with an elastomer compound. In a first state, the elastomer compound and the substrate delimit the flow channel in a section. In a second state, the elastomer compound takes up the space in the recess in the substrate along a cross-section of the flow channel, thereby completely closing the flow channel. The substrate and the elastomer compound may be produced by injection molding techniques.

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Номер записи: 3
03-05-2012 дата публикации

Cassette system integrated apparatus

Номер: US20120106289A1
Автор: Brian Tracey, James D. Dale, Jason A. Demers, Kevin L. Grant, Michael J. Wilt
Принадлежит: Deka Products LP

A cassette integrated system. The cassette integrated system includes a mixing cassette, a balancing cassette, a middle cassette fluidly connected to the mixing cassette and the balancing cassette and at least one pod. The mixing cassette is fluidly connected to the middle cassette by at least one fluid line and the middle cassette is fluidly connected to the balancing cassette by at least one fluid line. The at least one pod is connected to at least two of the cassettes wherein the pod is located in an area between the cassettes.

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Номер записи: 4
24-05-2012 дата публикации

Valve with material having modifiable degree of penetrability

Номер: US20120126154A1
Автор: Menno Willem Jose Prins, Remco Christian Den Dulk, Roel Penterman
Принадлежит: KONINKLIJKE PHILIPS ELECTRONICS NV

The invention relates to a valve ( 2 ) for controlling a passage of particles from a first region ( 6 ) to a second region ( 7 ), wherein the valve ( 2 ) comprises a valve material ( 4 ) having a modifiable degree of penetrability and a valve region ( 16 ) comprising the valve material ( 4 ), wherein the valve region ( 16 ) and the valve material ( 4 ) are adapted such that the particles have to penetrate the valve material ( 4 ) if the particles pass the valve ( 2 ) for being transferred from the first region ( 6 ) to the second region ( 7 ). The degree of opening of the valve ( 2 ) can easily be controlled by modifying the degree of penetrability of the valve material ( 4 ), for example, by modifying the temperature of the valve material ( 4 ). Moreover, by penetrating the valve material ( 4 ) the particles can be separated from other elements like a fluid containing the particles.

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Номер записи: 5
07-06-2012 дата публикации

Valve

Номер: US20120138180A1
Автор: James Edward Mccrone, Justin Rorke Buckland, Stuart Andrew Hatfield
Принадлежит: Technology Partnership PLC

A valve for controlling the flow of fluid having first ( 16 ) and second ( 14 ) plates with offsetting apertures and a sidewall ( 12 ) disposed between the plates around the perimeter of the plates to form a cavity ( 15 ) in fluid communication with the apertures is disclosed. The valve further comprises a flap ( 17 ) disposed and moveable between the first and second plates and having apertures ( 22 ) substantially offset from the apertures ( 20 ) of one plate ( 16 ) and substantially aligned with the apertures ( 18 ) of the other plate ( 14 ). The flap is motivated between the two plates in response to a change in direction of the differential pressure of fluid across the valve.

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Номер записи: 6
07-06-2012 дата публикации

Multi-Function Eccentrically Actuated Microvalves and Micropumps

Номер: US20120138833A1
Автор: Joseph Matteo
Принадлежит: Individual

Eccentrically actuated microvalves and micropumps. Microfluidic channels are formed in multi-layered laminar assemblies with at least one layer including an elastomeric material. In some embodiments, the microvalves and micropumps are controlled by eccentrically driven actuators, including in some embodiments cam-driven actuators. A cam-driven actuator activates a microvalve by pressing on the elastomeric layer, deforming the elastomeric layer so that it meets a second layer at a location within the channel, thereby either partially or completely obstructing the flow of liquid through the channel at that location, i.e. “pinching” the channel. The actuator is moved into position by a cam, which includes detents that allow the actuator to move away from the first layer or raised areas that force the actuator to move toward the first layer. Some embodiments include multiple microvalves, in which case a single cam, controlled by a single position-control mechanism, is able to control multiple microvalves. The resulting apparatuses are useful for controlling multi-channel microfluidic systems in an energy-efficient and space-efficient manner.

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Номер записи: 7
14-06-2012 дата публикации

System and method for microfluidic flow control

Номер: US20120145253A1
Автор: Gregory A. Dale, Shulin Zeng
Принадлежит: Canon US Life Sciences Inc

A system and method for controlling fluid flow within a microchannel includes a fluid circuit comprising a fluid outlet well and one or more fluid inlet wells, all in communication with a microchannel. A negative pressure differential is applied to the outlet well and fluid flow from an inlet well into the microchannel is controlled by opening or closing the inlet well to atmospheric pressure. To stop fluid flow from the inlet well, a negative pressure differential may be applied to the inlet well to equalize pressure between the inlet and outlet wells. By sequentially opening and closing different inlet wells to atmosphere, controlled amounts of different reagents can be serially introduced into the microchannel.

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Номер записи: 8
19-07-2012 дата публикации

Valves with Hydraulic Actuation System

Номер: US20120181460A1
Автор: David Eberhart, Ezra Van Gelder
Принадлежит: Integenx Inc

This invention provides a device comprising at least one diaphragm valve actuated by a hydraulic actuation system. The device comprises a fluidics layer, an actuation layer and an elastic layer sandwiched between the fluidics layer and the actuation layer. The diaphragm valve comprises: a valve inlet and valve outlet comprised in the fluidics layer; a valve seat; a diaphragm comprised in the elastic layer; and an actuator. The diaphragm is actuatable to move into contact or out of contact with the valve seat, thereby closing or opening the diaphragm valve. The actuator comprises: a hydraulic conduit; a translator; and an incompressible fluid contained within the hydraulic conduit, wherein the incompressible fluid communicates with the translator and with the diaphragm. Translation of the translator transmits pressure through the incompressible fluid to actuate the diaphragm. The invention also provides systems including elements to operate the device and methods of using the device.

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Номер записи: 9
19-07-2012 дата публикации

Selective bond reduction in microfluidic devices

Номер: US20120184046A1
Автор: Micah Atkin
Принадлежит: Individual

The invention overcomes the limitations described for the bonding of structured layers by providing a method for selectively reducing the bonding of materials. In its most generic form, the invention uses a bonding technique in combination with a printing method for modifying or covering at least one portion of a surface to either fully or partially prevent localised bonding. The structuring process may act upon the layers either before or after the bonding of the layers. The invention overcomes the limitations described in the application of affinity chromatography by providing a planar substrate with discrete optical detection flow cells that contain porous material and have connecting microchannels for fluid delivery and/or removal, and a method for making the same.

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Номер записи: 10
20-09-2012 дата публикации

Capillary Force Actuator Device and Related Method of Applications

Номер: US20120235538A1
Автор: Carl R. Knospe
Принадлежит: UNIVERSITY OF VIRGINIA PATENT FOUNDATION

An actuator capable of generates force by leveraging the changes in capillary pressure and surface tension that result from the application of an electrical potential. The device, which will be referred to as a Capillary Force Actuator (CFA), and related methods, employs a conducting liquid bridge between two (or more) surfaces, at least one of which contains dielectric-covered electrodes, and operates according to the principles of electrowetting on dielectric.

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Номер записи: 11
11-10-2012 дата публикации

Rack for sample tubes and reagent holders

Номер: US20120258463A1
Автор: Jeff Williams, Kalyan Handique, Kerry Wilson, Patrick Duffy
Принадлежит: HandyLab Inc

A rack for holding samples and various reagents, wherein the rack may be used for loading the samples and reagents prior to using the reagents. The rack accepts complementary reagent holders, each of which contain a set of reagents for carrying out a predetermined processing operation, such as preparing biological samples for amplifying and detecting polynucleotides extracted from the samples.

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Номер записи: 12
01-11-2012 дата публикации

Ferrofluid control and sample collection for microfluidic application

Номер: US20120275929A1
Автор: Kenneth Salsman
Принадлежит: Aptina Imaging Corp

A fluid conveyance system includes a flow passage and a cavity adjacent a side of the flow passage. A wall of the passage includes a flexible section that separates the cavity from the flow passage. The cavity contains a ferrofluidic material. The system further includes at least one magnetic field source positioned adjacent the flow channel. The magnetic field source is operable to move the ferrofluidic material in the cavity to exert a pressure on the flexible section and displace the flexible section into the flow passage to alter the flow of material through the passage. A method of collecting components from a sample volume includes the steps of distributing magnetic particles into the sample volume, capturing the components from the sample volume, and applying a magnetic field to the sample volume to control directional flow of the sample volume.

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Номер записи: 13
15-11-2012 дата публикации

Novel Electrostatically Addressable Microvalves

Номер: US20120285550A1
Автор: Ashish Pattekar, Eric Peeters, Eugene M. Chow
Принадлежит: Palo Alto Research Center Inc

A method of controlling a main fluid in a conduit using a microvalve is described. The microvalve includes a corresponding actuation aperture in an actuation aperture layer. A control fluid flows through the actuation aperture in response to an electric field applied via a charge distribution near an actuation aperture layer. In one embodiment, the electric field may adjust the opening and closing of the actuation aperture thereby controlling the flow of the control fluid. In a second embodiment, the control fluid is an electrorheological fluid where the electric field controls the viscosity of the ER fluid, thereby controlling fluid flow through the actuation aperture. In both embodiments the flow of the control fluid controls stretching of a flexible membrane into and out of the conduit, thereby controlling the flow of the main fluid by opening or closing the conduit.

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Номер записи: 14
22-11-2012 дата публикации

Systems and methods for valving on a sample processing device

Номер: US20120291565A1
Автор: Jeffrey D. Smith, Peter D. Ludowise
Принадлежит: 3M Innovative Properties Co

A system and method for valving on a sample processing device. The system can include a valve chamber, a process chamber, and a valve septum located between the valve chamber and the process chamber. The system can further include a fluid pathway in fluid communication with an inlet of the valve chamber, wherein the fluid pathway is configured to inhibit a liquid from entering the valve chamber and collecting adjacent the valve septum when the valve septum is in a closed configuration. The method can include rotating the sample processing device to exert a first force on the liquid that is insufficient to move the liquid into the valve chamber; forming an opening in the valve septum; and rotating the sample processing device to exert a second force on the liquid to move the liquid into the valve chamber.

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Номер записи: 15
13-12-2012 дата публикации

Micromechanic passive flow regulator

Номер: US20120316492A1
Автор: Eric Chappel
Принадлежит: Debiotech SA

The invention concerns a flow regulator, made of a stack of 3 plates, respectively a top plate including a flexible membrane ( 1 ), a middle plate ( 2 ) with pillars and through holes and a bottom plate ( 3 ) with fluidic ports, micro channels and through holes ( 8,9,12 ). The principle is based on the deformation of the membrane due to the pressure of the liquid. The membrane goes in contact with the pillars of the middle plate, obstructing gradually the through holes of the pillars. The device is designed to keep the flow constant in a predefined range of pressure. The device is dedicated to ultra low flow rate up to 1 ml per day or below, typically for drug infusion. Plastic flow regulators comprise preferably several independent valves coupled in parallel. The membrane plate is therefore made of several flexible membranes obstructing gradually the flow by increasing the pressure. Stress limiters are used to avoid plastic deformation of the membrane. For implanted pump, the use of a flow regulator instead of a flow restrictor has several advantages, including the possibility to reduce significantly the reservoir pressure and to generate directly the pressure during the pump filling by using an elastic drug reservoir.

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Номер записи: 16
27-12-2012 дата публикации

Microfabricated elastomeric valve and pump systems

Номер: US20120328834A1
Автор: Axel Scherer, Hou-Pu Chou, Marc A. Unger, Stephen R. Quake, Todd A. Thorsen
Принадлежит: California Institute of Technology CalTech

A method of fabricating an elastomeric structure, comprising: forming a first elastomeric layer on top of a first micromachined mold, the first micromachined mold having a first raised protrusion which forms a first recess extending along a bottom surface of the first elastomeric layer; forming a second elastomeric layer on top of a second micromachined mold, the second micromachined mold having a second raised protrusion which forms a second recess extending along a bottom surface of the second elastomeric layer; bonding the bottom surface of the second elastomeric layer onto a top surface of the first elastomeric layer such that a control channel forms in the second recess between the first and second elastomeric layers; and positioning the first elastomeric layer on top of a planar substrate such that a flow channel forms in the first recess between the first elastomeric layer and the planar substrate.

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Номер записи: 17
24-01-2013 дата публикации

Cassette system integrated apparatus

Номер: US20130022483A1
Автор: Brian Tracey, James D. Dale, Jason A. Demers, Kevin L. Grant, Michael J. Wilt
Принадлежит: Deka Products LP

A cassette integrated system. The cassette integrated system includes a mixing cassette, a balancing cassette, a middle cassette fluidly connected to the mixing cassette and the balancing cassette and at least one pod. The mixing cassette is fluidly connected to the middle cassette by at least one fluid line and the middle cassette is fluidly connected to the balancing cassette by at least one fluid line. The at least one pod is connected to at least two of the cassettes wherein the pod is located in an area between the cassettes.

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Номер записи: 18
14-02-2013 дата публикации

Micro-Fluidic System

Номер: US20130037139A1
Автор: Alex Calanca, Gianni Medoro, Nicolò Manaresi
Принадлежит: Silicon Biosystems SpA

A micro-fluidic system comprising a micro-fluidic channel, which has a wall provided with a hole; a closing element, which is partially housed within the hole and has a membrane portion adapted to deform and a side portion sealingly connected with the above mentioned wall; and a partition arranged within the micro-fluidic channel between a first and a second segment; the closing element is deformable between a locked configuration in contact with the partition and an open configuration spaced from the partition; the closing element may be deformed by suction or by a rod or a piston.

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Номер записи: 19
28-03-2013 дата публикации

Microfluidic dialysis device

Номер: US20130079254A1
Автор: Kia Silverbrook, Mehdi Azimi
Принадлежит: Geneasys Pty Ltd

A microfluidic dialysis device that has a first channel for receiving a biological sample, a second channel, and a series of adjacent channels extending between the first channel and the second channel. Each of the adjacent channels pin a meniscus of the sample that arrests capillary flow between the first channel and the second channel. A bypass channel between the first channel and the second channel, the bypass channel joining the second channel upstream of the adjacent channels and is configured for uninterrupted capillary driven flow from the first channel to the second channel. Flow from the bypass channel reaches the meniscus pinned at each of the adjacent channels after the meniscus has formed to sequentially remove each of the menisci and allow flow from the first channel to the second channel via the adjacent channels as well as the bypass channel.

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Номер записи: 20
02-05-2013 дата публикации

Idle Air Control Valve with Plastic Housing and Retention Features

Номер: US20130104842A1
Автор: Forgeron David Rene, Tamman Allen, Vink Francis Peter, Wang Calvin, Weldon Craig Andrew
Принадлежит: CONTINENTAL AUTOMOTIVE SYSTEMS, INC.

A linear actuator () includes a plastic housing () having an integral flange () for mounting the actuator. A stator assembly (), having windings (), is disposed in the plastic housing. A rotor assembly (), having a permanent magnet (), is mounted for rotation with respect to the stator assembly such that when the windings are energized, a magnetic field is generated to cause rotation of the rotor assembly. A shaft () is restricted from rotation and is associated with the rotor assembly such that rotation of the rotor assembly causes linear movement of the shaft. Connector structure () houses leads for powering the windings. The plastic housing has an annular end () that captures an annular surface () of the connector structure to couple the plastic housing to the connector structure. 1. A linear actuator comprising:a plastic housing having an integral flange for mounting the actuator,a stator assembly disposed in the plastic housing, the stator assembly having windings,a rotor assembly, having a permanent magnet, mounted for rotation with respect to the stator assembly such that when the windings are energized, a magnetic field is generated to cause rotation of the rotor assembly,a shaft restricted from rotation and associated with the rotor assembly such that rotation of the rotor assembly causes linear movement of the shaft, andconnector structure housing leads for powering the windings,wherein the plastic housing has an annular end that captures an annular surface of the connector structure, coupling the plastic housing to the connector structure.2. The actuator of claim 1 , wherein the flange includes bolt holes there-through claim 1 , a metal compression limiter being frictionally engaged with surfaces defining each bolt hole.3. The actuator of claim 1 , further comprising flux ring structure of ferrous material disposed about the stator assembly claim 1 , generally adjacent to the windings.4. The actuator of claim 1 , wherein the plastic housing and the stator ...

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Номер записи: 21
09-05-2013 дата публикации

Solenoid valve with a two-part core

Номер: US20130112904A1
Автор: Vincent Tanari
Принадлежит: FLUID AUTOMATION SYSTEMS SA

A magnetic core ( 210 ) for a solenoid valve is provided. The magnetic ( 210 ) includes a first part ( 210 a ) defining a cavity ( 213 ). The first part ( 210 a ) is formed from a first material having a first magnetic performance. The magnetic core ( 210 ) also includes a second part ( 210 b ) positioned at least partially within the cavity ( 213 ). The second part ( 210 b ) is formed from a second material having a second magnetic performance that is higher than the first magnetic performance.

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Номер записи: 22
16-05-2013 дата публикации

Microfluidic device with deformable valve

Номер: US20130121893A1
Автор: Emmanuel Delamarche, Laetitia C. Avrain, Martina Hitzbleck, Pascal Y. Mertens, Thierry C. Laurent, Valérie SMEKENS
Принадлежит: Coris Bioconcept SPRL, International Business Machines Corp

A microfluidic device includes a first microchannel, a second microchannel, and a valve comprising at least an input port and an output port, the ports respectively connected to the first microchannel and the second microchannel, the valve designed to control a flow of a liquid along a flow direction (z) defined by the ports; wherein the valve further comprises one or more walls joining the ports and defining a hollow chamber that is wider than each of the microchannels in a direction perpendicular to the flow direction, the walls at least partly deformable along a deformation direction (−y) intersecting the flow direction, such that the walls can be given at least a first deformation state and a second deformation state, such that the liquid can be pulled along the flow direction substantially more in the second deformation state than in the first deformation state.

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Номер записи: 23
23-05-2013 дата публикации

Microfluidic platform for discrete cell assay

Номер: US20130130301A1
Автор: Euisik Yoon, Kim Young-Ji
Принадлежит: University of Michigan

A microfluidic chamber for use in individual cell assays. The microfluidic chamber includes a cell microchamber having an interior region and front and rear valves, each of which are separately controllable so that they can be selectively opened and closed to thereby permit the transference of an individual cell into and out of the interior region. Cell secretion and contact interaction studies can be carried out using the microchambers, with the valves permitting either complete isolation or perfusion media flow through the microchambers. An internal perfusion wall can be included to partition the microchamber for non-contact perfusion studies of secretion interactions between cells.

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Номер записи: 24
06-06-2013 дата публикации

Microfluidic devices with mechanically-sealed diaphragm valves

Номер: US20130139895A1
Автор: Mattias Vangbo
Принадлежит: Integenx Inc

This invention provides a fluidic device comprising a diaphragm valve having a fluidics layer, an actuation layer and an elastic layer between the fluidics layer and the actuation layer, the elastic layer having a diaphragm that is mechanically sealed against the fluidics layer and the actuation layer by a sealing ring in the actuation layer.

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Номер записи: 25
27-06-2013 дата публикации

CHEMICAL DELIVERY SYSTEM

Номер: US20130160865A1
Автор: Brown Gary A., Fritze Karl J., Harris Jaime L., Kensinger David G.
Принадлежит: HYDRA-FLEX INC.

An expandable chemical delivery system sharing a common bulk fluid inlet and bulk fluid flow path to direct a bulk fluid through one or more selected chemical eductors. Each chemical eductor is slidably insertable into an eductor port on the manifold body such that rotation of the chemical eductor is not required for installation. After installation, the orientation of the chemical eductor can be rotatably adjusted so as to avoid interference with adjacent chemical eductors. Delivery of a bulk fluid to each chemical eductor is controlled via a corresponding valve assembly that selectively allows or blocks flow of the bulk fluid from the bulk fluid flow path to the corresponding chemical eductor. The manifold body can include a plurality of individual manifold bodies approximated with a coupling system to define the bulk fluid flow path. Alternatively, the manifold body can comprise a single fabricated body for high pressure operation. 1. A chemical delivery system , comprising:a manifold block including a bulk fluid inlet connected to a bulk fluid flow conduit, and wherein a plurality of individual fluid flow conduits fluidly intersect the bulk fluid flow conduit, each individual fluid flow conduit being intersected by a valve bore having a valve mounting port and each individual fluid flow conduit having an educator mounting port;at least one eductor assembly, each eductor assembly being individually attached to one of the educator mounting ports; anda plurality of valve assemblies, each valve assembly being individually mounted to one of the valve mounting ports so as to selectively control flow of a bulk fluid through the individual fluid flow conduits such that individual eductor assemblies can removed from operation without preventing flow of the bulk fluid through the bulk fluid flow conduit.2. The chemical delivery system of claim 1 , wherein each eductor assembly attaches to the corresponding eductor mounting port with a quick-connect fitting.3. The chemical ...

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Номер записи: 26
04-07-2013 дата публикации

VALVE SEAT, VALVE WITH SEAT AND METHOD OF FITTING SEAT TO VALVE

Номер: US20130168591A1
Автор: Webster David Wade
Принадлежит: Aker Solutions Singapore Pte Ltd

A valve seat () for use in a valve incorporating a valve gate is disclosed, the valve seat comprising a valve seat body () and a biasing device () such as a spring (), the biasing device being integral with the valve seat body. The biasing device and valve seat body may be welded together or may be formed in a single metal workpiece by a machining, casting or forging process. The valve gate and valve seat cooperate to form a metal-to-metal seal within the valve. At least a portion () of the valve seat is typically welded to at least a portion of the valve. A pipeline including at least one valve is also disclosed, as is a method of fitting a valve seat to a valve. 1. A valve seat comprising:a valve seat body;a biasing device; andwherein the biasing device is integral with the valve seat body.2. The valve seat according to claim 1 , wherein the biasing device and valve seat body are welded together.3. The valve seat according to claim 1 , wherein the biasing device and valve seat body comprise a single metal workpiece formed by a machining claim 1 , casting or forging process.4. The valve seat according to claim 1 , wherein said biasing device comprises a spring.5. The valve seat according to claim 1 , wherein said biasing device comprises an annular spring.6. The valve seat according to claim 1 , wherein said biasing device comprises an annular sigmoidal spring.7. The valve seat according to claim 6 , wherein said annular sigmoidal spring is provided with at least one substantially circular chamfer between two perpendicularly connected sections thereof.8. The valve seat according to claim 6 , wherein all perpendicularly connected sections of the sigmoidal spring are connected via substantially circular chamfers.9. The valve seat according to claim 1 , wherein a chamfer is provided between an external side wall and an end face of the valve seat claim 1 ,10. The valve seat according to claim 1 , wherein two chamfers are provided at both end faces and the external side ...

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Номер записи: 27
18-07-2013 дата публикации

PLUG HEAD ASSEMBLIES

Номер: US20130181154A1
Автор: Mock M. Robert, Redd Frank, Robison Jeffrey C.
Принадлежит: CALDERA ENGINEERING, LC

In accordance with various embodiments, a plug head assembly is provided comprising a ceramic plug head having a frustroconical geometry, wherein the ceramic plug head has a proximal terminus and a distal terminus, wherein the ceramic plug head has a first coefficient of thermal expansion (CTE), a sleeve having a frustroconical geometry conforming to the ceramic plug head and a second CTE, wherein the second CTE is greater than the first CTE, a distal retainer having a frustroconical geometry conforming to the sleeve, the distal retainer having a first engagement portion for engaging the a proximal retainer, the proximal retainer having a second engagement portion for engaging the distal retainer, and a base that couples with the proximal retainer. In addition, thick banded plug heads are provided 1. A plug head assembly comprising:a flat SiC plug head having a circumference;a thick band disposed about the circumference of the flat SiC plug head,wherein the thick band exerts a radial stress upon the flat SiC plug head at a room temperature and at an operating temperature,wherein a probability of survival of the flat SiC plug head under axial thermal expansion stress is greater than 95%.2. The plug head assembly of claim 1 , wherein the thick hand is comprised of a metal and wherein a hoop stress in the thick hand resulting from the radial stress at the room temperature is less than the yield strength of the metal.3. The plug head assembly of claim 1 , wherein the radial stress is from between 800 psi and 8000 psi at the operating temperature.4. The plug head assembly of claim 1 , wherein the ceramic plug head does not extend axially beyond the thick band.5. The plug head assembly of claim 1 , wherein the ceramic plug head extends minimally axially beyond the thick band.6. The plug head assembly of claim 1 , wherein the thick band comprises titanium.7. The plug head assembly of claim 2 , wherein the radial stress is from between 800 psi and 8000 psi at the operating ...

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Номер записи: 28
15-08-2013 дата публикации

DEVICE AND METHOD FOR MANIPULATING A LIQUID

Номер: US20130206264A1
Автор: RODENFELS Tobias
Принадлежит: BOEHRINGER INGELHEIM INTERNATIONAL GMBH

The invention relates to a device and method for manipulating a liquid in a channel, wherein a body, which forms a capillary intermediate space with respect to the channel wall, is moved in the channel and the channel is filled with liquid only up to the body. Preferably, the body can also bridge an area of the channel that cannot be wetted for the liquid. 1123243436422632463324. A device () for the manipulation of a liquid () , having a channel () for receiving the liquid () and having a body () that is movable in the channel () , characterised in that the body () fills the channel () by more than 60% of its cross-sectional area and an intermediate space () is formed between the body () and the channel wall , so that the liquid () or its front A is held in the intermediate space () by capillary forces and the channel () is filled with the liquid () only up to the body () or end of the intermediate space () , and/or in that the channel () comprises at least one non-wettable region (A) which can be bridged for the liquid () by means of the body ().243. The device according to claim 1 , characterised in that the body () is guided in a defined alignment in the channel ().3424. The device according to claim 1 , characterised in that the body () is laterally guided by a film of the liquid () between the body () and the channel wall.443. The device according to claim 1 , characterised in that the body () has a length that is greater than the maximum cross-section of the channel ().54. The device according to claim 1 , characterised in that the body () is of elongate configuration.64. The device according to claim 1 , characterised in that the body () is movable magnetically and/or in a contactless manner.7743. The device according to claim 1 , characterised in that a manipulating device () is provided for moving the body () along the channel ().8433. The device according to claim 1 , characterised in that the body () is selectively movable into different regions or ...

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Номер записи: 29
15-08-2013 дата публикации

FLOW CONTROL VALVE AND A METHOD OF ASSEMBLING A FLOW CONTROL VALVE

Номер: US20130207014A1
Автор: Abramowicz Marcin, Andersen Ejner Kobberoe, Birkelund Michael, Nissen Birthe Reese, Porland John, Van Beek Johan
Принадлежит: Danfoss A/S

A flow control valve () and a method for assembling a flow control valve () are disclosed. The flow control valve () comprises a first housing part () and a second housing part () attached directly to each other, in such a manner that the first housing part () and the second housing part () form a substantially closed housing. The first housing part () defines a first flow section (), a second flow section (), a connecting port () fluidly interconnecting the first flow section () and the second flow section (), and a valve seat () arranged at the connecting port (). The flow control valve () further comprises a frame part () arranged in an interior part of the housing formed by the first housing part () and the second housing part (), the frame part () having mounted thereon a valve element () arranged movably relative to the valve seat (), a moving mechanism, e.g. including a spindle (), for moving the valve element (), and an actuating mechanism, e.g. a stepper motor (), for operating the moving mechanism. The frame part (9) is attached directly to the first housing part () or to the second housing part (). The frame part () along with the components mounted thereon can be mounted on the first () or second () housing part during the assembly of the flow control valve (). The final assembly step thereby only includes attaching the first () and second () housing parts to each other. This makes the assembly process easy, thereby reducing the risk of errors. 1. A flow control valve comprising:a first housing part defining a first flow section, a second flow section, a connecting port fluidly interconnecting the first flow section and the second flow section, and a valve seat arranged at the connecting port,a second housing part being attached directly to the first housing part, in such a manner that the first housing part and the second housing part form a substantially closed housing,a frame part arranged in an interior part of the housing formed by the first housing ...

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Номер записи: 30
15-08-2013 дата публикации

VALVE, IN PARTICULAR OF A HYDRAULIC PISTON PUMP

Номер: US20130209298A1
Автор: Gaertner Oliver, Schuessler Michael, Schuller Wolfgang
Принадлежит: ROBERT BOSCH GMBH

In a valve, in particular of a hydraulic pixton pump, includes a valve seat, a valve closing element, and a positioning mechanism. A valve opening is formed in the valve seat. The valve seat also has a front side and a rear side. The valve closing element is arranged on the front side of the valve seat in order to open and close the valve opening as desired. The positioning mechanism is configured to hold the valve closing elementrelative to the valve seat. The positioning mechanism is arranged on the rear side of the valve seat and is connected to the valve closing element through the valve opening. 1. A valve of a hydraulic piston pump comprising: a valve opening formed in the valve seat;', 'a front side; and', 'a rear side;, 'a valve seat includinga valve closing element arranged on the front side of the valve seat and configured to selectively open and close the valve opening; anda positioning mechanism configured to hold the valve closing element relative to the valve seat, wherein the positioning mechanism is arranged on the rear side of the valve seat and is connected to the valve closing element through the valve opening.2. The valve as claimed in claim 1 , wherein the positioning mechanism is configured to position the valve closing element in a direction of a longitudinal extent of the valve.3. The valve as claimed in claim 1 , wherein the positioning mechanism is configured to position the valve closing element transversely to a longitudinal extent of the valve.4. The valve as claimed in claim 1 , wherein the positioning mechanism includes a latching element latched in on the rear side of the valve seat.5. The valve as claimed in claim 1 , further comprising:a return mechanism arranged on the rear side of the valve seat and configured to urge the valve closing element against the valve seat.6. The valve as claimed in claim 5 , wherein the return mechanism is clamped between the positioning mechanism and the rear side of the valve seat.7. The valve as ...

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Номер записи: 31
15-08-2013 дата публикации

Microfluidic chips and assay systems

Номер: US20130209327A1
Автор: Lincoln C. Young, Peng Zhou
Принадлежит: Rheonix Inc

The systems and methods described herein include a microfluidic chip having a plurality of microfeatures interconnected to provide a configurable fluid transport system for processing at least one reagent. Inserts are provided to removably interfit into one or more of the microfeatures of the chip, wherein the inserts include sites for interactions with the reagent. As will be seen from the following description, the microfluidic chip and the inserts provide an efficient and accurate approach for conducting parallel assays.

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Номер записи: 32
15-08-2013 дата публикации

Microfluidic chip comprising several cylinder-piston arrangements

Номер: US20130209328A1
Автор: Daniel Latta, Klaus-Stefan Dresse, Marion Ritzi-Lehnert, Tina Roeser
Принадлежит: INSTITUT FUER MIKROTECHNIK MAINZ GMBH

A microfluidic arrangement including a substrate in which a mircofluidic structure having several adjacent channels and at least one common supply line, into which the adjacent channels merge, is formed. Each of the adjacent channels form the cylinder of a cylinder-piston arrangement for receiving an associated piston. A method for producing the type of microfluidic-arrangement is also disclosed.

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Номер записи: 33
03-10-2013 дата публикации

FLUIDIC ACTOR COMPRISING DEFORMABLE SEAL ARRANGEMENT AND LONG STORABILITY

Номер: US20130255812A1
Автор: Gessner Thomas, NESTLER Joerg, OTTO Thomas
Принадлежит:

A fluidic actuator includes a basic arrangement having at least one cavity formed therein, an activatable substance within the cavity, and a deformable seal arrangement. The activatable substance, exemplarily an electrolyte, may be converted, at least partly, by suitable activation and thus cause a change in pressure in the cavity. The deformable seal arrangement serves for sealing the cavity. The seal arrangement includes an element containing paraffin and may be deformed when activating the activatable substance due to the change in pressure of the activatable substance. A corresponding method of manufacturing includes the following steps: providing the basic arrangement; forming a cavity, which is open on at least one side, in the basic arrangement; introducing the activatable substance into the cavity; and sealing the cavity using the deformable seal arrangement which includes an element containing paraffin. 1. A fluidic actuator comprising:a basic arrangement comprising at least one cavity formed therein;an activatable substance within the cavity, configured to be converted, at least partly, by means of suitable activation and thus cause a change in pressure in the cavity; anda deformable seal arrangement for sealing the at least one cavity, wherein the seal arrangement comprises a film comprising a paraffin portion or an expandable film comprising a paraffin layer on at least one main surface and may be deformed when activating the activatable substance due to the change in pressure.2. The fluidic actuator in accordance with claim 1 , wherein the expandable film comprises at least one of the following materials: natural rubber claim 1 , silicone rubber claim 1 , butyl rubber claim 1 , and polybutadiene.3. The fluidic actuator in accordance with claim 1 , wherein the paraffin layer is arranged on the expandable film in the area of the at least one cavity.4. The fluidic actuator in accordance with claim 1 , wherein the paraffin layer is arranged on the ...

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Номер записи: 34
24-10-2013 дата публикации

METHOD FOR CONTROLLING AN ACTUATOR OR VALVE

Номер: US20130276897A1
Автор: MOHR Carsten
Принадлежит:

A method for regulating an actuator or valve, wherein to execute a regulating function of the actuator or a valve function of the valve an actuating pulse is used, which is fed to the actuator or valve, characterized in that between at least two consecutive actuating pulses at least one additional pulse or a stochastic signal is fed to the actuator or valve. 1. A method for regulating an actuator or valve , comprising the steps of:transmitting a series of actuating pulses to the actuator or valve; and,transmitting an additional pulse or a stochastic signal to said actuator or valve between at least two of said actuating pulses, wherein said additional pulse or said stochastic signal acts neutrally in terms of regulating function with respect to the actuator, and wherein said additional pulse acts neutrally in terms of valve function with respect to the valve, and wherein said additional pulse causes a sound to be emitted from the actuator or valve.2. The method recited in claim 1 , wherein the actuating pulse and/or the at least one additional pulse and/or the stochastic signal are electric or hydraulic.3. The method recited in claim 1 , wherein the amplitude of the at least one additional pulse and/or of the stochastic signal is less than the amplitude of the actuating pulse.4. The method recited in claim 1 , wherein the stochastic signal is bandpass-filtered so that its frequency range is limited. This application is filed under 35 U.S.C. §120 and §365(c) as a continuation of International Patent Application No. PCT/DE2011/001786 filed Sep. 29, 2011, which application claims priority from German Patent Application No. 10 2010 049 925.0 filed Oct. 28, 2010, which applications are incorporated herein by reference in their entireties.The invention relates to a method for controlling an actuator or valve.DE 195 40 099 A1 discloses a system for active noise reduction.Due to their continuous motion, switching actuators or valves often produce structure-borne noise ...

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Номер записи: 35
31-10-2013 дата публикации

MICROFLUIDIC VALVE SYSTEMS AND METHODS

Номер: US20130284956A1
Автор: Kwon Jae Wan
Принадлежит: The Curators of the University of Missouri

The present disclosure provides a mini-scale microfluidic valve including a valve housing disposed at a fluid dispensing orifice of a mini-scale microfluidic system dispensing nozzle. The valve housing comprises a base member having a base member orifice that aligns with the fluid dispensing orifice to provide a fluid dispensing pathway through which a system-fluid is dispensed from the system dispensing nozzle to an external ambient environment. The housing additionally comprises an open valve channel exposed to the external ambient environment and intersecting the fluid dispensing pathway. The valve further includes a liquid-film movably disposed within the open valve channel such that the liquid-film is exposed to the external ambient environment. The liquid-film comprises a substantially non-volatile, immiscible liquid, and a valve control subsystem structured and operable to control movement of the liquid-film within the open valve channel to selectively cover and uncover the base member orifice. 1. A mini-scale microfluidic valve structured and operable to selectively cover and uncover a mini-scale microfluidic system fluid dispensing nozzle orifice , said valve comprising:a base member provided at a fluid dispensing orifice of a mini-scale microfluidic system dispensing nozzle, the nozzle orifice providing a fluid dispensing pathway for dispensing system-fluid from the mini-scale microfluidic system to an external ambient environment, the base member comprising a top surface that is exposed to the external ambient environment, wherein a fluid-air interface is present within the nozzle orifice between the external ambient environment and the system-fluid present in the nozzle orifice;a liquid-film movably disposed on the base member top surface such that the liquid-film is exposed to the external ambient environment, the liquid-film comprising a substantially non-volatile liquid that is substantially immiscible with the system-fluid; anda valve control ...

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Номер записи: 36
31-10-2013 дата публикации

OUTLET VALVE FOR USE WITH A PRESSURIZED FLUID CONTAINER

Номер: US20130284957A1
Автор: Edwards Richard, Gass Simon, Tarczewski Jacek
Принадлежит: Norgren Limited

An outlet valve () adapted for use with a pressurized fluid container includes an outlet valve chamber () including an upper groove () and a lower groove (), an outlet valve member () configured to move between substantially open and substantially closed positions in the outlet valve chamber (), and a non-return member () configured to be retained in one of the upper groove () or the lower groove () in a snap-fit arrangement. When the non-return member () is retained in the upper groove () the non-return member () does not contact the outlet valve member (). When the non-return member () is retained in the lower groove () the non-return member () blocks the outlet valve member () in the substantially open position. 1700700. An outlet valve () adapted for use with a pressurized fluid container , the outlet valve () comprising:{'b': 701', '722', '725, 'an outlet valve chamber () including an upper groove () and a lower groove ();'}{'b': 760', '701, 'an outlet valve member () configured to move between substantially open and substantially closed positions in the outlet valve chamber (); and'}{'b': 780', '722', '725', '780', '722', '780', '760', '780', '725', '780', '760, 'a non-return member () configured to be retained in one of the upper groove () or the lower groove () in a snap-fit arrangement, wherein when the non-return member () is retained in the upper groove () the non-return member () does not contact the outlet valve member () and wherein when the non-return member () is retained in the lower groove () the non-return member () blocks the outlet valve member () in the substantially open position.'}2700780. The outlet valve () of claim 1 , wherein the non-return member () is formed of an at least partially deformable material.3700760. The outlet valve () of claim 1 , wherein the outlet valve member () moves substantially linearly from the open position to the substantially closed position.4700780760780722. The outlet valve () of claim 1 , wherein the non- ...

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Номер записи: 37
07-11-2013 дата публикации

VALVE STEM ASSEMBLY FOR ROTARY VALVE AND METHOD

Номер: US20130292595A1
Автор: LANNING WILLIAM W., MAKI ROBERT EARL
Принадлежит: WORLDWIDE OILFIELD MACHINE, INC.

A valve body defines a valve stem opening. A valve stem comprises an enlarged portion greater than the valve stem opening to thereby secure the valve stem within the valve body by limiting radially outward movement of the valve stem with respect to the valve body. A rotary member comprise upper and lower bosses. Upper and lower split trunnions, with split components that can be inserted from opposite sides of the valve body, are used to rotationally support the upper and lower bosses to permit rotation of the rotary member while preventing axial movement of the axial flow path of the valve. 120-. (canceled)21. A rotary valve , comprising:a valve body with a first opening on one side of said valve body and a second opening on an opposite side of said valve body, said valve body defining a fluid flow path through said valve body along a valve body axis through said first opening and said second opening of said valve body, said valve body further defining a valve stem opening;a valve stem comprising an enlarged portion, said enlarged portion comprising a diameter greater than said valve stem opening to thereby secure said valve stem within said valve body by limiting radially outward movement of said valve stem with respect to said valve body;a first set of split support elements comprising a first split support element and a second split support element, said first split support element and said second split support element each comprising a continuous curved engagement surface, and when said first set of split support elements are mounted within said valve body then said first set of split support elements form a first circular opening with said continuous curved engagement surfaces with a split between said split support elements;a rotary member with a first extension, said first extension being positioned within said first circular opening defined within said first set of split support elements whereby said first extension is rotatable within said first circular ...

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Номер записи: 38
06-02-2014 дата публикации

RECONFIGURABLE MICROACTUATOR AND METHOD OF CONFIGURING SAME

Номер: US20140034141A1
Автор: Burns Mark A., GULARI ERDOGAN, Hua Zhishan, Pal Rohit, SRIVANNAVIT Onnop
Принадлежит: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

A microactuator may be configured by activating a source of electromagnetic radiation to heat and melt a selected set of phase-change plugs embedded in a substrate of the microactuator, pressurizing a common pressure chamber adjacent to each of the plugs to deform the melted plugs, and deactivating the source of electromagnetic radiation to cool and solidify the melted plugs. 1. A method for configuring a microactuator including a substrate having a plurality of phase-change plugs embedded therein , the method comprising:activating a source of electromagnetic radiation to heat and melt a selected set of the plugs;pressurizing a common pressure chamber adjacent to each of the plugs to deform the melted plugs; anddeactivating the source of electromagnetic radiation to cool and solidify the melted plugs thereby latching the deformed plugs.2. The method of further comprising depressurizing the common pressure chamber.3. The method of further comprising reactivating the source of electromagnetic radiation to heat and melt the deformed plugs.4. The method of wherein the deformed plugs protrude from a surface of the substrate.5. A reconfigurable latchable microactuator system comprising:a substrate assembly including a plurality of membrane-covered actuation cells embedded therein, each of the actuation cells being configured to melt if heated by a source of electromagnetic radiation; anda helmet chip operatively arranged with the substrate assembly to form a common pressure chamber adjacent to the actuation cells, each of the actuation cells being further configured to deform when melted if subjected to pressure via the pressure chamber.6. The system of wherein each of the actuation cells are further configured to protrude from the substrate assembly when melted if subjected to pressure via the pressure chamber.7. The system of wherein the actuation cells form an array on the substrate assembly.8. The system of wherein the actuation cells comprise at least one of a wax ...

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Номер записи: 39
13-02-2014 дата публикации

Microfluidic and nanofluidic devices, systems, and applications

Номер: US20140045704A1
Автор: Allen R. Boronkay, Joanne Horn, luliu I. Balga, Mattias Vangbo, Michael Van Nguyen, Stevan Bogdan Jovanovich, William D. Nielsen
Принадлежит: Integenx Inc

The present invention discloses the integration of programmable microfluidic circuits to achieve practical applications to process biochemical and chemical reactions and to integrate these reactions. In some embodiments workflows for biochemical reactions or chemical workflows are combined. Microvalves such as programmable microfluidic circuit with Y valves and flow through valves are disclosed. In some embodiments microvalves of the present invention are used for mixing fluids, which may be part of an integrated process. These processes include mixing samples and moving reactions to an edge or reservoir for modular microfluidics, use of capture regions, and injection into analytical devices on separate devices. In some embodiments star and nested star designs, or bead capture by change of cross sectional area of a channel in a microvalve are used. Movement of samples between temperature zones are further disclosed using fixed temperature and movement of the samples by micropumps.

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Номер записи: 40
20-03-2014 дата публикации

MICROFLUIDIC OSCILLATOR PUMP

Номер: US20140079571A1
Автор: Duncan Philip N., Hui Elliot E., Nguyen Transon V.
Принадлежит: The Regents of the University of California

Microfluidic oscillator circuits and pumps for microfluidic devices are provided. The microfluidic pump may include a plurality of fluid valves and a microfluidic oscillator circuit having an oscillation frequency. The fluid valves may be configured to move fluids. Each fluid valve may be connected to a node of the microfluidic oscillator circuit. The pumps may be driven by the oscillator circuits such that fluid movement is accomplished entirely by circuits on a microfluidic chip, without the need for off-chip controls. 1. A microfluidic pump , located on a microfluidic device , the microfluidic pump comprising:a microfluidic oscillator circuit having an oscillation frequency; anda plurality of fluid valves configured to move fluids, each fluid valve connected to a node of the microfluidic oscillator circuit.2. The microfluidic pump of claim 1 , wherein the microfluidic oscillator circuit includes:an odd number of inverter logic gates implemented by pneumatic or hydraulic valves, the logic gates being connected in a closed loop, anda plurality of nodes, each node being located between two inverter logic gates.3. The microfluidic pump of claim 2 , wherein the oscillation frequency varies as a function of the number of inverter logic gates in the oscillator circuit.4. The microfluidic pump of claim 2 , wherein the microfluidic oscillator circuit has a volume comprising the volume of the pneumatic or hydraulic valves and the volume of the channels connecting the pneumatic or hydraulic valves claim 2 , wherein the oscillation frequency varies as a function of the volume of the microfluidic oscillator circuit.5. The microfluidic pump of claim 2 , wherein each inverter logic gate includes a pull-up resistor having a pull-up resistance claim 2 , and wherein the oscillation frequency of the circuit varies as a function of the pull-up resistance of the inverter logic gates of the circuit.6. The microfluidic pump of claim 1 , wherein the microfluidic oscillator circuit is ...

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Номер записи: 41
03-04-2014 дата публикации

Devices and Methods for Flow Control in Microfluidic Structures

Номер: US20140090716A1
Автор: James C. Nurse, John R. Van Camp
Принадлежит: APPLIED BIOSYSTEMS LLC

An apparatus for controlling flow in a fluid flow path can include a chamber containing an expandable material, the expandable material being configured to expand out of the chamber into a portion of the fluid flow path so as to at least partially block the fluid flow path. The apparatus also can include at least one structure providing flow communication between the chamber and the fluid flow path. The at least one structure can be configured to pass the expandable material from the chamber to the portion of the fluid flow path during expansion so as to control a rate at which the expandable material expands into the portion of the fluid flow path.

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Номер записи: 42
03-04-2014 дата публикации

Valved, Microwell Cell-Culture Device And Method

Номер: US20140090735A1
Автор: Paul Ju-Sung Hung, Philip Janmin Lee
Принадлежит: EMD Millipore Corp

A valved microfluidics device, microfluidics cell-culture device and system incorporating the devices are disclosed. The valved microfluidics device includes a substrate, a microchannel through which liquid can be moved from one station to another within the device, and a pneumatic microvalve adapted to be switched between open and closed states to control the flow of fluid through a microchannel. The microvalve is formed of three flexible membranes, one of which is responsive to pneumatic pressure applied to the valve and the other two of which deform to produce a more sealable channel cross-section. The cell culture device provides valving to allow controlled loading of cells into the individual well of the device, and exchange of cell-culture components in the wells.

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Номер записи: 43
07-01-2021 дата публикации

MICROFLUIDIC VALVE AND METHOD OF MAKING SAME

Номер: US20210001334A1
Автор: Haley Cecelia, Handique Kalyan, Parunak Gene
Принадлежит:

The present technology provides for a microfluidic substrate configured to carry out PCR on a number of polynucleotide-containing samples in parallel. The substrate can be a single-layer substrate in a microfluidic cartridge. Also provided are a method of making a microfluidic cartridge comprising such a substrate. Still further disclosed are a microfluidic valve suitable for use in isolating a PCR chamber in a microfluidic substrate, and a method of making such a valve. 118.-. (canceled)19. A method of making a microfluidic valve , the method comprising:directing a dispensing head over an inlet hole in a microfluidic substrate;propelling a quantity of thermally responsive substance from the dispensing head into the inlet hole;maintaining a temperature of the microfluidic substrate so that the thermally responsive substance flows by capillary action into a microfluidic channel in communication with the inlet hole; andcovering the inlet hole.20. The method of claim 19 , wherein covering the inlet hole comprises covering two or more inlet holes.21. The method of claim 19 , wherein covering the inlet hole comprises covering two or more inlet holes for valves that are in a sample lane of the microfluidic substrate.22. The method of claim 19 , wherein covering the inlet hole comprises covering two or more inlet holes for valves that are in different sample lanes of the microfluidic substrate.23. The method of claim 19 , wherein covering the inlet hole comprises covering the microfluidic substrate with a layer of plastic.24. The method of claim 19 , wherein covering the inlet hole comprises covering the microfluidic substrate with a layer comprising a pressure sensitive adhesive.25. The method of claim 19 , wherein propelling a quantity of thermally responsive substance comprises propelling a quantity of thermally responsive substance to the bottom of the inlet hole.26. The method of claim 19 , wherein propelling a quantity of thermally responsive substance comprises ...

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Номер записи: 44
02-01-2020 дата публикации

MICRO ELECTRICAL MECHANICAL SYSTEM (MEMS) MULTIPLEXING MIXING

Номер: US20200001257A1
Автор: Fry Jonathan, Piper Daniel, Sim Jang, Xin Yongchun
Принадлежит:

A MEMS multiplexing system including: first and second fluid inputs; and a mixing network. The mixing network including: a first channel to receive the first fluid input; a second channel to receive the second fluid input; a multiplexing valve communicating with the first channel and the second channel, the multiplexing valve to cause the transport of the first fluid into the second channel so as to form a first interleaved fluid downstream from the multiplexing valve in the second channel and to cause the transport of the second fluid into the first channel so as to form a second interleaved fluid downstream from the multiplexing valve in the first channel; and the first channel and the second channel intersecting downstream from the valve so as to force mixing of the first interleaved fluid and the second interleaved fluid. 1. A micro electrical mechanical system (MEMS) multiplexing system comprising:a first fluid input in a mixing system;a second fluid input in the mixing system; a first channel to receive the first fluid input;', 'a second channel to receive the second fluid input;', 'a multiplexing valve communicating with the first channel and the second channel, the multiplexing valve to cause the transport of the first fluid into the second channel so as to form a first interleaved fluid downstream from the multiplexing valve in the second channel and to cause the transport of the second fluid into the first channel so as to form a second interleaved fluid downstream from the multiplexing valve in the first channel;', 'the first channel and the second channel intersecting downstream from the valve so as to force mixing of the first interleaved fluid and the second interleaved fluid to form a mixture of the first interleaved fluid and the second interleaved fluid; and', 'an output channel to discharge the mixture of the first interleaved fluid and the second interleaved fluid., 'a mixing network in the mixing system comprising2. The system of wherein the ...

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Номер записи: 45
05-01-2017 дата публикации

MICROFABRICATED ELASTOMERIC VALVE AND PUMP SYSTEMS

Номер: US20170001195A1
Автор: Adams Mark L., Chou Hou-Pu, Enzelberger Markus, Hansen Carl L., Quake Stephen R., Scherer Axel, Thorsen Todd A., Unger Marc Alexander
Принадлежит:

A method of fabricating an elastomeric structure, comprising: forming a first elastomeric layer on top of a first micromachined mold, the first micromachined mold having a first raised protrusion which forms a first recess extending along a bottom surface of the first elastomeric layer; forming a second elastomeric layer on top of a second micromachined mold, the second micromachined mold having a second raised protrusion which forms a second recess extending along a bottom surface of the second elastomeric layer; bonding the bottom surface of the second elastomeric layer onto a top surface of the first elastomeric layer such that a control channel forms in the second recess between the first and second elastomeric layers; and positioning the first elastomeric layer on top of a planar substrate such that a flow channel forms in the first recess between the first elastomeric layer and the planar substrate. 1. (canceled)2. The method of using a microfluidic device , comprising:flowing a sample into a looped channel of the microfluidic device;pumping the sample around the loop channel with a peristaltic action, wherein the peristaltic action comprises sequential activation of a series of individually addressable valves arranged along the looped channel.3. The method of claim 2 , wherein the series of individually addressable valves comprise three valves.4. The method of claim 3 , wherein each of the three valves is an intersection of an individually addressable control line over the looped channel.5. The method of claim 2 , wherein the microfluidic device is an elastomeric device.6. The method of claim 2 , wherein the pumping passes the sample over a DNA array. This nonprovisional patent application is a continuation of U.S. application Ser. No. 14/188,664 filed Feb. 24, 2014, which is a continuation of Ser. No. 11/932,263 filed Oct. 31, 2007, now U.S. Pat. No. 8,656,958, which is a continuation of U.S. application Ser. No. 11/685,654 filed Mar. 13, 2007, now U.S. Pat. ...

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Номер записи: 46
02-01-2020 дата публикации

PARTICLE SORTING APPARATUS, SYSTEM, AND METHOD

Номер: US20200001328A1
Автор: ITO Tatsumi
Принадлежит:

A particle sorting apparatus is provided. The particle sorting apparatus includes a first light irradiating unit including a first mirror and a first light source for irradiating a first light to particles flowing through a flow path at a first position; a second light irradiating unit including a second mirror and a second light source configured to irradiate a second light to particles flowing through the flow path at a second position which is different from the first position; a light detecting unit is configured to detect a light emitted from the particles; a sorting unit; and a sorting control unit configured to control sorting of the particles based on data of the particles detected at the light detecting unit and an arrival time associated with a time difference between a light from the first light irradiating unit and a light from the second light irradiating unit; wherein the flow path and the sorting unit are provided within a microchip. 1. A particle sorting apparatus , comprising:a first light irradiating unit including a first mirror and a first light source for irradiating a first light to particles flowing through a flow path at a first position;a second light irradiating unit including a second mirror and a second light source configured to irradiate a second light to particles flowing through the flow path at a second position which is different from the first position;a light detecting unit is configured to detect a light emitted from the particles;a sorting unit; anda sorting control unit configured to control sorting of the particles based on data of the particles detected at the light detecting unit and an arrival time associated with a time difference between a light from the first light irradiating unit and a light from the second light irradiating unit;wherein the flow path and the sorting unit are provided within a microchip.2. The particle sorting apparatus according to claim 1 , wherein the sorting control unit is configured to calculate ...

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Номер записи: 47
05-01-2017 дата публикации

Low Leak Pilot Operated Spool Valve

Номер: US20170002932A1
Автор: Fuller E. Nelson, Gurley Gengxun K.
Принадлежит: DUNAN MICROSTAQ, INC.

A hybrid spool valve includes a body having a longitudinal bore. The bore has a fluid inlet chamber in fluid communication with a fluid inlet port and a fluid outlet chamber in fluid communication with a fluid outlet port. A spool is slidably mounted in the bore and is movable between a fully open position, a fully closed position, and a plurality of partially open positions. A pilot microvalve is mounted within the bore and is configured to control the sliding movement of the spool by varying the flow of fluid therethrough. A seal is disposed in a groove formed in an outside surface of the spool such that when the spool is in the fully closed position the seal engages a wall of the bore, and when the spool is the fully open position or one of the partially open positions the seal does not engage the bore. 1. A hybrid spool valve comprising:a body defining a longitudinally extending bore, the bore having a fluid inlet chamber in fluid communication with a fluid inlet port and a fluid outlet chamber in fluid communication with a fluid outlet port;a spool slidably mounted in the bore and having a first and a second end, the spool configured for sliding movement between a fully open position, which allows fluid flow from the fluid inlet chamber to the fluid outlet chamber, a fully closed position, which restricts fluid flow from the fluid inlet chamber to the fluid outlet chamber, and a plurality of partially open positions, which allows at least some fluid to flow from the fluid inlet chamber to the fluid outlet chamber;a pilot microvalve mounted within the bore adjacent the first end of the spool and configured to control the sliding movement of the spool by varying the flow of fluid therethrough; anda seal disposed in a groove formed in an outside surface of the spool, wherein when the spool is in the fully closed position, the seal engages a wall of the bore, and wherein when the spool is in one of the fully open and partially open positions, the seal does not ...

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Номер записи: 48
05-01-2017 дата публикации

ELECTRONIC DEVICE, WEARABLE DEVICE, PRESSURE REGULATOR VALVE AND METHOD FOR MANUFACTURING PRESSURE REGULATOR VALVE

Номер: US20170002939A1
Автор: KATSUDA Hiroshi, NISHIYAMA Hiroki, OHMURA Akihisa, Suzuki Akira
Принадлежит: CASIO COMPUTER CO., LTD.

An electronic device includes a housing and an internal pressure regulator valve. The internal pressure regulator valve includes a valve body of flexible material. The valve body has a valve hole and a hollow. The hollow is continuous with the valve hole and opens into the housing. Through the valve hole, gas is released to outside. 1. An electronic device comprising:a housing; andan internal pressure regulator valve including a valve body of flexible material having: a valve hole through which gas is released to outside; and a hollow which is continuous with the valve hole and opens into the housing.2. The electronic device according to claim 1 , wherein the valve body further has a projection which projects to the outside claim 1 , containing the valve hole.3. The electronic device according to claim 1 , wherein the internal pressure regulator valve opens claim 1 , thereby releasing the gas in the housing to the outside claim 1 , when an internal pressure of the housing is higher than an external pressure.4. The electronic device according to claim 3 , wherein the internal pressure regulator valve opens claim 3 , thereby releasing the gas in the housing to the outside claim 3 , when (i) the internal pressure is higher than the external pressure and (ii) a difference between the internal pressure and the external pressure is equal to or larger than a first predetermined difference.5. The electronic device according to claim 1 , wherein the internal pressure regulator valve closes claim 1 , thereby blocking liquid from entering the housing from the outside claim 1 , when an internal pressure of the housing is lower than an external pressure.6. The electronic device according to claim 5 , wherein the internal pressure regulator valve closes claim 5 , thereby blocking the liquid from entering the housing claim 5 , when (i) the internal pressure is lower than the external pressure and (ii) a difference between the internal pressure and the external pressure is equal to ...

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Номер записи: 49
04-01-2018 дата публикации

Device Having a Plurality of Latching Micro-Actuators and Method of Operating the Same

Номер: US20180003319A1
Автор: Besse Nadine, Rosset Samuel, Shea Herbert, Zarate Juan José
Принадлежит:

An actuator device including a plurality of transducer actuators, and a common pneumatic actuation mechanism for shaping the plurality of transducer actuators, wherein each actuator of the plurality of transducer actuators includes a shape memory polymer membrane, an integrated stretchable heater, and a pressure interface to the common pneumatic actuation mechanism. 1. An actuator device comprising:a plurality of transducer actuators; anda common pneumatic actuation mechanism for shaping the plurality of transducer actuators,wherein each actuator of the plurality of transducer actuators includes,a shape memory polymer membrane,an integrated stretchable heater, andan pressure interface to the common pneumatic actuation mechanism.2. The actuator device according to claim 1 , further comprising:a power control device to control electric power supplied to the integrated stretchable heater of each actuator of the plurality of transducer actuators, to selectively activate the transducer actuators individually.3. The actuator device according to claim 1 , wherein the common pneumatic actuation mechanism comprises:a pump that is configured to generate a positive and a negative pressure; anda pneumatic chamber having a common inlet that is arranged below the shape memory polymer membrane having a plurality of channels, each channel connected to a corresponding pressure interface of a corresponding actuator,wherein the pump is operatively connected to the common inlet of the pneumatic chamber.4. The actuator device according to claim 1 , wherein the pressure interface is made from an opening of a flexible printed circuit board.5. The actuator device according to claim 1 , wherein each shape memory polymer membrane is configured such that the common pneumatic actuation mechanism displaces only the actuators that are heated by the corresponding integrated stretchable heater.6. The actuator device according to claim 1 , further comprising:a microfluidic chip including ...

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Номер записи: 50
03-01-2019 дата публикации

SYSTEM AND METHOD FOR PROCESSING BIOLOGICAL SAMPLES

Номер: US20190002959A1
Автор: Kusner Michael T., Williams Jeffrey
Принадлежит:

A system and method for processing and detecting nucleic acids from a set of biological samples, comprising: a molecular diagnostic module configured to receive nucleic acids bound to magnetic beads, isolate nucleic acids, and analyze nucleic acids, comprising a cartridge receiving module, a heating/cooling subsystem and a magnet configured to facilitate isolation of nucleic acids, a valve actuation subsystem including an actuation substrate, and a set of pins interacting with the actuation substrate, and a spring plate configured to bias at least one pin in a configurations, the valve actuation subsystem configured to control fluid flow through a microfluidic cartridge for processing nucleic acids, and an optical subsystem for analysis of nucleic acids; and a fluid handling system configured to deliver samples and reagents to components of the system to facilitate molecular diagnostic protocols. 1. A system for processing a biological sample comprising:a cartridge platform receiving a cartridge including a fluidic pathway, wherein the cartridge platform comprises an access region configured to align with the fluidic pathway; a pin comprising a first end, a second end opposing the first end, and a pin slot defined along a length of the pin between the first and the second end, the pin actuatable along a displacement axis extending through the first end, the second end, and the access region; and', 'an actuation substrate translatable along an actuation axis between a first substrate position, wherein a first substrate feature of the actuation substrate passes through the pin slot to transmit the pin through the access region; and a second substrate position, wherein a second substrate feature of the actuation substrate passes through the pin slot to transmit the pin away from the access region., 'a valve actuation subsystem comprising2. The system of claim 1 , wherein the valve actuation system further comprises a spring coupled to a region of the pin claim 1 , ...

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Номер записи: 51
20-01-2022 дата публикации

PORTABLE VAPORIZING DEVICE, CARTRIDGE AND METHODS

Номер: US20220015435A1
Автор: BAJPAI Avinash, SAYRE Roger, VOLODARSKY Roger
Принадлежит:

A portable vaporizing device and/or cartridge comprises a product chamber capable of holding a vaporizable product therein, and a porous valve element configured to be heated to flow the vaporizable product therethrough and generate vapor from the vaporizable product, and optionally including a heat transfer element to heat the vaporizable product as it flows through the product chamber towards the porous valve element. 1. A portable vaporizing device comprising:a vaporizable product receiving chamber configured to receive a vaporizable product therein, the vaporizable product receiving chamber comprising one or more chamber walls defining an product flow path between upper and lower opposing ends of the vaporizable product receiving chamber;a heat transfer element extending at least partly along the product flow path, and configured to transfer heat to vaporizable product received in the product receiving chamber to at least partially melt and/or reduce the viscosity of vaporizable product as it flows via gravitational pull from the upper end to the lower end along the product flow path; and a porous valve body comprising porous material configured to allow heated vaporizable product having a predetermined viscosity to pass therethrough;', 'at least one first porous entry surface of the porous valve body configured to receive the heated vaporizable product from the product flow path into the porous valve body; and', 'at least one porous vaporizing surface of the porous valve body configured to flow the heated vaporizable product out of the porous valve body,, 'a porous valve element located towards the lower end of the vaporizable product receiving chamber, the porous valve element comprisingwherein the heat transfer element and porous valve element are configured to be placed in thermal contact with at least one heating element to provide heating of the heat transfer element and porous valve element during operation of the portable vaporizing device to heat the ...

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Номер записи: 52
14-01-2016 дата публикации

Methods and Systems for Enhanced Microfluidic Processing

Номер: US20160008811A1
Автор: Amy Droitcour, Daniel Laser, Hailemariam NEGUSSIE, William BEHNKE-PARKS
Принадлежит: WAVE 80 BIOSCIENCES Inc

Methods and systems are provided for a microfluidic cartridge including a high performance actuator useful for analyte detection, labeling and analysis. Microfluidic processing systems are to carry out chemical or biochemical reactions, or sequences of reactions, with small volumes (typically between 1 microliter and 10 milliliters) of reactants and products. A microfluidic processing system can comprise a network of tubes interfaced with discrete components such as valves and sensors, or an integrated device made of plastic, glass, metal, or other materials, or a combination of materials, with components such as valves and sensors built into the device and connected by flow passageways formed in the material.

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Номер записи: 53
08-01-2015 дата публикации

Microfluidic Bubble Logic Devices

Номер: US20150011404A1
Автор: Manu Prakash, Neil Gershenfeld
Принадлежит: Massachusetts Institute of Technology

Fluid-based no-moving part logic devices are constructed from complex sequences of micro- and nanofluidic channels, on-demand bubble/droplet modulators and generators for programming the devices, and micro- and nanofluidic droplet/bubble memory elements for storage and retrieval of biological or chemical elements. The input sequence of bubbles/droplets encodes information, with the output being another sequence of bubbles/droplets or on-chip chemical synthesis. For performing a set of reactions/tasks or process control, the modulators can be used to program the device by producing a precisely timed sequence of bubbles/droplets, resulting in a cascade of logic operations within the micro- or nanofluidic channel sequence, utilizing the generated droplets/bubbles as a control. The devices are based on the principle of minimum energy interfaces formed between the two fluid phases enclosed inside precise channel geometries. Various devices, including logic gates, non-volatile bistable memory, ring oscillators, bubble synchronizers, analysis chips, sample collectors, and printers have been designed.

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Номер записи: 54
14-01-2016 дата публикации

Long-Throw Microfluidic Actuator

Номер: US20160010761A1
Автор: Droitcour Amy, Frey Jared, Laser Daniel, Negussie Hailemariam, Raduta Radu
Принадлежит:

A microfluidic device includes a three-dimensional slat structure having a plurality of interstices configured to generate a high power, high flow rate of fluids by electroosmotic flow. The microfluidic device includes a housing for holding and moving fluids through the slat structure, and a plurality of electrodes that generate an electric field within the plurality of interstices. 1. A device comprising:a slat structure comprising a rigid structural frame supporting a plurality of approximately evenly spaced slats, such slats having a thickness, and wherein said slat structure comprises a plurality of interstices between said slats and said plurality of interstices comprise a plurality of fluid passageways extending through said thickness such that a fluid is capable of flowing through said slat structure, wherein each of said plurality of interstices has an in-plane dimension a and a second in-plane dimension b, wherein said dimension a is between 1 and 10 microns and said dimension b is at least the lesser of fifty times greater than said dimension a of said interstice or 250 microns; and the number of interstices is at least ten; a first structure defining a first fluid cavity adapted for housing a fluid and in fluidic communication with a first side of said interstices;', 'a second structure defining a second fluid cavity adapted for housing a fluid and in fluidic communication with a second side of said interstices, wherein said first fluid cavity, said plurality of interstices in said slat structure, and said second fluid cavity define a fluid pathway, wherein a lowest flow resistance path from said first fluid cavity to said second fluid cavity is through said plurality of interstices; and, 'a housing enclosing said slat structure, comprisinga plurality of electrodes for generating an electric field within said plurality of interstices.2. The device of claim 1 , wherein said slat structure claim 1 , said housing claim 1 , and said plurality of electrodes ...

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Номер записи: 55
14-01-2021 дата публикации

MICROFLUIDIC SYSTEM FOR AMPLIFYING AND DETECTING POLYNUCLEOTIDES IN PARALLEL

Номер: US20210010059A1
Автор: Brahmasandra Sundaresh N., Ganesan Karthik, Handique Kalyan, Williams Jeff
Принадлежит:

The present technology provides for an apparatus for detecting polynucleotides in samples, particularly from biological samples. The technology more particularly relates to microfluidic systems that carry out PCR on nucleotides of interest within microfluidic channels, and detect those nucleotides. The apparatus includes a microfluidic cartridge that is configured to accept a plurality of samples, and which can carry out PCR on each sample individually, or a group of, or all of the plurality of samples simultaneously. 1. A method of carrying out amplification on a plurality of samples , the method comprising:introducing each of the plurality of samples into an amplification zone of a multi-lane microfluidic cartridge;isolating each of the plurality of samples within the multi-lane microfluidic cartridge;independently thermally cycling each amplification zone; andamplifying polynucleotides contained within each of the plurality of samples.2. The method of claim 1 , further comprising detecting the presence of a polynucleotide or a polynucleotide probe in the plurality of samples.3. The method of claim 1 , wherein independently thermally cycling each amplification zone comprises heating each amplification zone with a plurality of heaters.4. The method of claim 1 , wherein independently thermally cycling each amplification zone comprises heating each amplification zone with four heaters.5. The method of claim 1 , wherein independently thermally cycling each amplification zone comprises heating each amplification zone with two long heaters and two short heaters.6. The method of claim 1 , wherein isolating each of the plurality of samples comprises closing at least one valve.7. A method of carrying out amplification on a plurality of samples claim 1 , the method comprising:introducing a sample of a plurality of samples into an amplification zone in a lane of a multi-lane microfluidic cartridge;isolating the sample from the plurality of samples within the multi-lane ...

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Номер записи: 56
03-02-2022 дата публикации

System And Method For Valve Control

Номер: US20220032017A1
Автор: CHOWDHURY Shilpika, Henschel Mark E., Ruben David A., Sutanto Jemmy, Wasson James
Принадлежит:

Disclosed is a system including a flow control assembly. The system may include a flow regulating shunt system, for various purposes. The flow control assembly may be controlled according to selected parameters and methods. 1. A flow and/or pressure regulating assembly for a hydrocephalus shunt system , the regulating assembly comprising:a reservoir having a reservoir inlet and a reservoir outlet;a controller;a valve seat;a valve member configured to be supported relative to the valve seat to regulate flow into the reservoir through the reservoir inlet; andan actuator in response to an actuator signal from the controller to move between an activate position and an inactivate position;wherein the actuator is selectively positioned in the active position or the inactive position to assist in the valve member regulating the flow into the reservoir.2. The system of claim 1 , further comprising:an arm support member;wherein the arm support member is configured to bias the valve member in a closed position relative to the valve seat.3. The system of claim 2 , further comprising:a substrate positioned on a side of the arm support member away from the valve member;wherein the actuator is a formed from and on the substrate.4. The system of claim 2 , further comprising:a valve support member configured to hold the valve member;wherein the arm support extends from the valve support member to a connection.5. The system of claim 1 , further comprising:a pressure sensor configured to sense a pressure within the reservoir and transmit a pressure signal relating the sensed pressure to the controller.6. The system of claim 5 , wherein the controller is configured to execute instructions to compare the sensed pressure transmitted via the pressure signal and a predetermined set point pressure.7. The system of claim 6 , wherein the controller is configured to transmit the actuator signal to move the actuator between the activate position and the inactivate position based on the ...

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Номер записи: 57
03-02-2022 дата публикации

System And Method For Valve Control

Номер: US20220032018A1
Автор: CHOWDHURY Shilpika, Henschel Mark E., Ruben David A., Sutanto Jemmy, Wasson James
Принадлежит:

Disclosed is a system including a flow control assembly. The system may include a flow regulating shunt system, for various purposes. The flow control assembly may be controlled according to selected parameters and methods. 1. A method of operating a flow and/or pressure regulating assembly for a hydrocephalus shunt system , the method comprising:biasing a valve member in a closed position relative to a valve seat with an arm support member;sensing a parameter relative to the valve member; andoperating an actuator formed from and on a substrate near the arm support member to be positioned in an active position or an inactive position relative to the arm support member to effect a biasing force applied to the valve member.2. The method of claim 1 , further comprising:selecting an effective support length of the arm support member to determine the biasing force on the valve member.3. The method of claim 2 , further comprising:executing instructions with a controller to compare a sensed pressure applied to an inlet side of the valve member to determine the position of the actuator.4. The method of claim 3 , wherein operating the actuator in the active position includes decreasing a support length of the arm support member to increase the biasing force.5. The method of claim 3 , wherein operating the actuator in the inactive position includes increasing or maximizing a support length of the arm support member to decrease the biasing force.6. The method of claim 1 , further comprising:selecting a set point for the parameter;comparing the set point of the parameter to the sensed parameter; andselecting a position of the actuator based on the comparison.7. The method of claim 6 , wherein the parameter is an inlet pressure.8. The method of claim 7 , further comprising:receiving the selected set point; andstoring the set point.9. The method of claim 7 , further comprising:executing instructions with a controller to perform the comparison;transmitting an actuation signal to ...

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Номер записи: 58
03-02-2022 дата публикации

TEMPERATURE CONTROLLED VALVES FOR PAPER-BASED MICROFLUIDIC SYSTEMS

Номер: US20220032286A1
Автор: Chiu Megan Zaiyi, Linnes Jacqueline C., SHEN Rui
Принадлежит: PURDUE RESEARCH FOUNDATION

The present invention relates to a low-cost, thermally reversible valve for paper-fluidic diagnostic devices. In particular, this invention demonstrates a tunable valve mechanism fabricated by wax-ink printing and localized heating via thin-film resistors to sequentially release liquids through a cellulose or nitrocellulose membrane. The wax-ink valve can obstruct fluid flow for a sustained time and are thermally actuated to release a controlled amount of liquid past the valve. This integrated paper-fluidic diagnostic assay device requires minimal user involvement, can be easily manufactured and tuned to meet various fluid delivery timing and incubation needs. 1. A method for testing a sample for the presence or absence of a nucleic acid of said sample comprising the steps of: a first thermally reversible barrier, wherein the first thermally reversible barrier defines an assay area, and a plurality of heating and temperature control components comprising a conductive ink printed resistor operatively positioned proximate said first thermally reversible barrier, wherein the first thermally reversible barrier includes an associated inlet and an associated outlet across a membrane and selectively operates according to four states: 1) an un-actuated state, where the first thermally reversible barrier is placed adjacent the membrane whereby fluid is free to travel across the membrane; 2) an actuated state when temperature of the first thermally reversible barrier is raised to a first predetermined threshold, where the first thermally reversible barrier melts and permeates into the membrane whereby fluid is stopped from travelling across the membrane, after which the temperature is allowed to be at or below the first predetermined threshold; 3) a closed state when temperature of the first thermally reversible barrier is below a second predetermined threshold, where the first thermally reversible barrier remains permeated in the membrane thereby fluid is stopped from ...

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Номер записи: 59
03-02-2022 дата публикации

Fluid device

Номер: US20220032336A1
Автор: Hannes Wirtl, Martin Maichl
Принадлежит: Festo SE and Co KG

A fluid device with a fluid chamber, the fluid device including a fluid chamber which is designed for receiving a fluid and which is commonly delimited by a device housing and a bending-elastic membrane element. The membrane element is fixed with a peripheral edge region to the device housing, wherein a membrane working section of the membrane element which is framed by the peripheral edge region can be deflected by a piezoactuator whilst carrying out a stroke movement, in order to change the volume of the fluid chamber. The membrane element is a functional constituent of the piezoactuator by way of it directly forming an electrically conductive electrode of the electrode arrangement of the piezoactuator.

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Номер записи: 60
03-02-2022 дата публикации

APPARATUS, SYSTEM, AND METHOD USING IMMISCIBLE-FLUID-DISCRETE-VOLUMES

Номер: US20220033896A1
Автор: Cox David M., Lee Linda G., Ma Congcong, Oldham Mark F., REEL Richard T., SCHROEDER Benjamin G., SORENSON Jon M., WIYATNO Willy, WOO Sam L.
Принадлежит: APPLIED BIOSYSTEMS, LLC

Various embodiments of the teachings relate to a system or method for sample preparation or analysis in biochemical or molecular biology procedures. The sample preparation can involve small volume processed in discrete portions or segments or slugs, herein referred to as discrete volumes. A molecular biology procedure can be nucleic acid analysis. Nucleic acid analysis can be an integrated DNA amplification/DNA sequencing procedure. 1. A method comprising:contacting a stream of aqueous sample fluid flowing in a first conduit with a stream of non-aqueous spacing fluid that is immiscible with the aqueous sample fluid to form discrete volumes of the aqueous sample fluid separated from one another by the non-aqueous spacing fluid, wherein the aqueous sample fluid comprises target nucleic acid, and wherein a first plurality of the discrete volumes contains at least one molecule comprising the target nucleic acid and a second plurality of the discrete volumes contains no molecules comprising the target nucleic acid;amplifying the target nucleic acid in one or more of the first plurality of the discrete volumes to form an amplicon;in a second conduit, detecting a fluorescence signal from the amplicon in the one or more of the first plurality of the discrete volumes; andbased on the detecting, discriminating between the one or more of the first plurality of the discrete volumes and the second plurality of the discrete volumes.2. The method of claim 1 , wherein the contacting comprises continuously flowing at least one of the aqueous sample fluid and the non-aqueous spacing fluid into the first conduit.3. The method of claim 1 , further comprising separating the second plurality of the discrete volumes from the first plurality of the discrete volumes.4. The method of claim 1 , wherein less than 37% of the first plurality of the discrete volumes comprise a single molecule comprising the target nucleic acid.5. The method of claim 4 , wherein 1% or more of the first plurality ...

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Номер записи: 61
03-02-2022 дата публикации

METHOD OF DIAGNOSING A VALVE, DIAGNOSIS MODULE, AND VALVE

Номер: US20220034424A1
Автор: Hartmann Christian
Принадлежит:

A method of diagnosing a valve is described, which has an electrodynamic actuator, which includes a magnet arrangement for generating a magnetic field and a control element which is movable relative to the magnet arrangement and is coupled to a movably arranged coil. At least one electrical variable of the electrodynamic actuator is measured over a measurement period to detect a time course of the electrical variable. The time course of the electrical variable is evaluated over an evaluation period to determine at least one induction-dependent valve variable which is assigned to the motion profile of the electrodynamic actuator. A diagnosis module and a valve are furthermore described. 1. A method of diagnosing a valve having an electrodynamic actuator , which comprises a magnet arrangement for generating a magnetic field and a control element which is movable relative to the magnet arrangement and coupled to a movably arranged coil , the method comprising the following steps:measuring at least one electrical variable of the electrodynamic actuator over a measurement period to detect a time course of the electrical variable, andevaluating the time course of the electrical variable over an evaluation period to determine at least one induction-dependent valve variable which is assigned to a motion profile of the electrodynamic actuator.2. The method according to claim 1 , wherein the electrical variable of the electrodynamic actuator is measured by means of a diagnosis module which is electrically inserted into an electric circuit of the coil of the electrodynamic actuator.3. The method according to claim 1 , wherein the at least one valve variable is at least one of a travelled path of the coil claim 1 , a duration of movement of the coil claim 1 , a speed profile of the coil claim 1 , and an acceleration profile of the coil.4. The method according to claim 1 , wherein when evaluating the time course of the electrical variable claim 1 , a time reference course of the ...

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Номер записи: 62
18-01-2018 дата публикации

INTEGRATED FLUIDIC MODULE

Номер: US20180015467A1
Автор: Liang Qian, Liu Yi-Shao, Utama Revata
Принадлежит:

An integrated fluidic module includes a fluid manifold, a valve stator, a valve rotor and a valve housing. The fluid manifold includes microchannels connected to a sample reaction unit, and fluid input channels connected to fluid sources. The valve stator includes at least one groove and plural through holes, at least one groove is connected with at least one of the plural through holes, and parts of the groove and through holes are communicated with the microchannels and the fluid input channels. The valve rotor includes at least one groove. The valve housing accommodates the valve rotor and the valve stator. When the valve rotor is rotated to different positions, at least one groove of the valve rotor is connected with at least one through hole or groove of the valve stator to provide at least one fluid path and enable fluids provided by the fluid sources to be directed to corresponding chambers of the sample reaction unit through the fluid path. 1. An integrated fluidic module connected with a sample reaction unit having multiple chambers to regulate fluid operations in a multi-fluid-system , the integrated fluidic module comprising:a fluid manifold comprising a main body, plural microchannels and plural fluid input channels, wherein each of the plural microchannels penetrates through the main body and is connected with a corresponding chamber of the sample reaction unit, and the plural fluid input channels are connected with plural fluid sources;a valve stator attached to the fluid manifold and comprising at least one groove and plural through holes, wherein the at least one groove of the valve stator is disposed on a top surface or a bottom surface of the valve stator and is directly connected with at least one of the plural through holes, and at least parts of the groove and the through holes are communicated with the plural microchannels and plural fluid input channels of the fluid manifold;a valve rotor attached to the valve stator and comprising at least ...

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Номер записи: 63
17-01-2019 дата публикации

METHOD AND APPARATUS FOR SORTING PARTICLES

Номер: US20190015841A1
Автор: Bohm Sebastian, Deshpande Manish, Gilbert John R.
Принадлежит:

A method and apparatus for sorting particles moving through a closed channel system of capillary size comprises a bubble valve for selectively generating a pressure pulse to separate a particle having a predetermined characteristic from a stream of particles. The particle sorting system may further include a buffer for absorbing the pressure pulse. The particle sorting system may include a plurality of closely coupled sorting modules which are combined to further increase the sorting rate. The particle sorting system may comprise a multi-stage sorting device for serially sorting streams of particles, in order to decrease the error rate. 1. A microfluidic system for sorting particles , the microfluidic system comprising:a first microfluidic flow channel formed in a particle processing component substrate having an upstream inlet configured to introduce a fluidic stream having a plurality of particles into the first microfluidic flow channel and downstream outlets configured to output portions of the fluidic stream of particles;a detection region located downstream of the inlet, the detection region configured to allow a particle having a predetermined characteristic to be sensed, the sensed particle being one of the plurality of particles in the fluidic stream; anda switching device located downstream of the detection region, the switching device operatively coupled to the first microfluidic flow channel to deliver a transient pressure pulse in a direction substantially perpendicular to a flow direction of the fluidic stream of particles,wherein the transient pressure pulse displaces and separates a selected single sensed particle from the fluidic stream of particles,wherein the selected particle is displaced and separated from the fluidic stream of particles in a switching region,wherein the fluidic stream of unselected particles flows into a first downstream outlet configured to output a first portion of the fluidic stream of particles,wherein the selected particle ...

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Номер записи: 64
18-01-2018 дата публикации

Sieve Valves, Microfluidic Circuits, Microfluidic Devices, Kits, and Methods for Isolating an Analyte

Номер: US20180016633A1
Автор: BLAINEY Paul, KIM SOOHONG
Принадлежит:

The invention generally provides a sieve valve including: a substrate defining a channel; a flexible membrane adapted and configured for deployment at an intersection with the channel; and one or more protrusions extending into the channel from the substrate or the flexible membrane. The one or more protrusions define a plurality of recesses extending beyond the intersection between the channel and the flexible membrane; 1. A method of isolating an analyte , the method comprising:loading a sample into a holding chamber of a microfluidic circuit, the microfluidic circuit including one or more sieve valves, wherein the holding chamber is in fluid communication with an input port of a mixing circuit,capturing an analyte on a capture substrate in the mixing circuit;washing the capture substrate to remove uncaptured components; and a substrate defining a channel;', 'a flexible membrane adapted and configured for deployment at an intersection with the channel; and', 'one or more protrusions extending into the channel from the substrate or the flexible membrane, the one or more protrusions defining a plurality of recesses extending beyond the intersection between the channel and the flexible membrane; and, 'releasing the analyte from the capture substrate, wherein the sieve valve comprises'}passing the sample into the mixing circuit.2. The method of claim 1 , wherein the capture substrate is loaded into the microfluidic circuit claim 1 , the holding chamber claim 1 , and/or the mixing circuit.3. The method of claim 1 , wherein the capture substrate comprises a bead claim 1 , microbead claim 1 , surface of the microfluidic circuit claim 1 , or a capture reagent.4. The method of claim 1 , wherein the mixing circuit comprises a plurality of chambers in fluid communication with one or more holding chambers claim 1 , wherein the one or more holding chambers and/or the mixing circuit comprises the capture substrate for isolating the analyte.5. The method of claim 4 , wherein the ...

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Номер записи: 65
21-01-2016 дата публикации

MICROFLUIDIC VALVE HAVING IMPROVED TOLERANCE TO PARTICLES

Номер: US20160018021A1
Автор: Chappel Eric
Принадлежит:

The present invention describes a valve for controlling the passage of a microfluidic system. Said valve comprises a first valve element () and a second valve element () with respective first and second contact surfaces which are placed opposite to each other in such a way as to control a fluid flow through said passage. Said first valve element comprising a flexible part and a rigid part. 2. The valve according to the claim 1 , wherein the flexible part is designed to bend in a direction perpendicular to a plan of the surface of the rigid part.3. The valve according to claim 1 , wherein the surface of the planar component and/or the surface of the second valve element has a Knoop hardness of at least 300 KHN.4. The valve according to claim 1 , wherein the surface of the planar component and/or the surface of the second valve element has a Knoop hardness of at least 500 KHN.5. The valve according to claim 1 , wherein the surface of the planar component and/or the surface of the second valve element has a Knoop hardness of at least 800 KHN.6. The valve according to claim 1 , wherein the surface of the planar component and/or the surface of the second valve element has a Knoop hardness of at least 1100 KHN.7. The valve according to the claim 1 , wherein the hardness factor of the flexible part is substantially equal to the hardness factor of the rigid part according to the Knoop hardness scale.8. The valve according to the claim 1 , wherein the hardness factor of the planar component is substantially equal to the hardness factor of the second valve element according to the Knoop hardness scale.9. The valve according to the claim 1 , wherein said first valve element further comprises a support which is fixed to the planar component.10. The valve according to claim 9 , wherein said rigid part is constituted by stacking of said support and said planar component.11. The valve according to claim 1 , wherein said second valve element comprises at least two parts:{'b': 1', ' ...

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Номер записи: 66
18-01-2018 дата публикации

INTEGRATED HEATER AND MAGNETIC SEPARATOR

Номер: US20180017184A1
Автор: Handique Kalyan
Принадлежит:

An apparatus for providing thermal and magnetic energy to a receptacle containing a reaction mixture and a magnetic retention member. The apparatus can also control heating of a reaction mixture, and bring about a separation of magnetic particles from the reaction mixture. The reaction mixture typically comprises polynucleotides from a biological sample that are being brought into a PCR-ready form. 128.-. (canceled)29. A method of extracting nucleic acids using a rack and an integrated separator and heater , the integrated separator and heater comprising a plurality of heater units aligned collinearly along a horizontal first axis , the integrated separator and heater further comprising one or more magnets disposed on a first side of the plurality of heater units and aligned along a second axis parallel to the first axis , the method comprising:inserting a plurality of holders in the rack, each holder comprising a single process tube of a plurality of process tubes;inserting the rack into the integrated separator and heater such that at least a portion of rack is removably received on a second side of the plurality of heater units opposite the one or more magnets on the first side, wherein a portion of each process tube of the plurality of process tubes is received in a single heater unit of the plurality of heater units when the rack is inserted into the integrated separator and heater;moving all of the one or more magnets backwards and forwards together in a vertical direction perpendicular to the second axis while maintaining proximity to an exterior side of each of the process tubes received in the integrated separator and heater;during at least a portion of the motion, moving magnetic particles contained in the process tubes; andindependently controlling each heater unit of the plurality of heater units to apply heat to the plurality of process tubes received in the integrated separator and heater.30. The method of claim 29 , wherein all of the one or more ...

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Номер записи: 67
17-04-2014 дата публикации

Fluidic interface valve assembly with elastomeric ferrule device

Номер: US20140102568A1
Автор: Carl M. Servin
Принадлежит: Idex Health and Science LLC

A tubing interface having an elongated tube, an elastomeric ferrule and a support ring device disposed around the ferrule. The ferrule includes a bore which is sized for receipt of the tube. The tubing interface further includes a cap member having an exterior surface, an opposed interior surface, and a tube receiving passage extending therethrough. The receiving passage is formed and dimensioned for axial sliding receipt of the tube member therethrough. The cap member further includes a cup-shaped receiving recess extending proximally from the interior surface, and is formed and dimensioned for axial receipt of the proximal end of the ferrule body member and the support ring. When the cap member is mounted to a valve apparatus, the support ring and the elastomeric ferrule device compressively cooperate with the cup-shaped recess to form a fluid-tight seal between the tube port and a communication port of the valve apparatus.

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Номер записи: 68
17-01-2019 дата публикации

Long-Throw Microfluidic Actuator

Номер: US20190017629A1
Автор: Droitcour Amy, Frey Jared, Laser Daniel, Negussie Hailemariam, Raduta Radu
Принадлежит:

A microfluidic device includes a three-dimensional slat structure having a plurality of interstices configured to generate a high power, high flow rate of fluids by electroosmotic flow. The microfluidic device includes a housing for holding and moving fluids through the slat structure, and a plurality of electrodes that generate an electric field within the plurality of interstices. 156.-. (canceled)57. A microfluidic cartridge comprising:a plurality of fluid passageways;at least one junction connecting said plurality of fluid passageways; and {'sup': '−8', 'a fluid power generation capacity of at least 10watts and capable of sustaining said power for at least 30 seconds; and'}, 'at least two fluid transport means, including at least one high-performance fluidic actuator, the at least one high-performance fluidic actuator being a discrete component within the cartridge, and the at least one high-performance fluidic actuator havinga response time for fluid power generation of less than 10 seconds.58. The cartridge of claim 57 , wherein said cartridge has a displaced volume less than or equal to five hundred cubic centimeters or less than or equal to fifty cubic centimeters.59. The cartridge of claim 57 , wherein said at least one high-performance fluidic actuator is capable of transducing electrical power into fluidic power.60. The cartridge of claim 57 , wherein said actuator is capable of pressurizing at least 10 microliters of liquid claim 57 , such that said liquid flows through a fluidic resistance associated with a back pressure of at least 1 kPa at a flow rate of at least 0.1 mL per minute.61. The cartridge of claim 57 , wherein said high-performance actuator is coupled to a pulse generator or other controlled time-varying voltage source and at least one electrode.62. The cartridge of claim 57 , wherein said at least one high-performance fluidic actuator is capable of producing fluidic power through an electrokinetic effect.63. The cartridge of claim 62 , ...

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Номер записи: 69
16-01-2020 дата публикации

SUB-PASCAL UNIDIRECTIONAL FLOW VALVES

Номер: US20200017813A1
Автор: Chen Christopher S., Chopra Anant, Michas Christos, White Alice Elizabeth
Принадлежит:

A valve includes a body including an inner bore extending between a first port and a second port, a seat, and one or more restrainers and a disk that is moveable between the seat and the one or more restrainers such that a first pressure that is less than 1 pascal and applied in a first direction causes the disk to move from a first position towards a second position to permit fluid communication between the first port and the second port. A metamaterial scaffold including a structure defining a lumen, at least a portion of an outer or non-lumen surface of the structure is coated with a plurality of biological cells, and wherein the structure is composed of a metamaterial. 1. A valve comprising:a body including an inner bore extending between a first port and a second port, a seat, and one or more restrainers; anda disk that is moveable between the seat and the one or more restrainers such that (i) a first pressure that is less than 1 pascal and applied in a first direction causes the disk to move from a first position towards a second position to permit fluid communication between the first port and the second port and (ii) a second pressure that is less than 1 pascal and applied in a second opposing direction causes the disk to move from the second position towards the first position to inhibit fluid communication between the first port and the second port.2. The valve of claim 1 , wherein the first pressure and the second pressure are less than 0.5 pascals.3. The valve of claim 1 , wherein the first pressure is between about 0.1 pascals and about 0.5 pascals.4. The valve of claim 1 , wherein the second pressure is between about 0.05 pascals and about 0.2 pascals.5. The valve of claim 1 , wherein the disk is moveable such that the first pressure causes the disk to move from the first position to the second position in less than 500 milliseconds.6. The valve of claim 1 , wherein the body is cylindrical and has a first diameter is that is 400 microns or less and a ...

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Номер записи: 70
17-04-2014 дата публикации

SHAPE MEMORY ALLOY ACTUATED VALVE ASSEMBLY

Номер: US20140103232A1
Автор: Deperraz Nicolas
Принадлежит: Fluid Automation Systems S.A

A valve assembly () is provided. The valve assembly () comprises a housing () including a plurality of fluid couplings (-). The valve assembly () further includes two or more valve members (-) movable within the housing () between a first position and a second position. A shape memory alloy element () is coupled to the two or more valve members (-) to independently actuate each of the two or more valve members (-) between the first and second positions upon heating a selected portion of the shape memory alloy element () above a transformation temperature. 1100. A valve assembly () , comprising:{'b': 102', '103', '104', '104, 'i': a', 'd, 'a housing () including a plurality of fluid couplings (, -);'}{'b': 107', '107', '102, 'i': a', 'd, 'two or more valve members (-) movable within the housing () between a first position and a second position; and'}{'b': 108', '107', '107', '107', '107', '108, 'i': a', 'd', 'a', 'd, 'a shape memory alloy element () coupled to the two or more valve members (-) to independently actuate each of the two or more valve members (-) between the first and second positions upon heating a selected portion of the shape memory alloy element () above a transformation temperature.'}2100109109108ae. The valve assembly () of claim 1 , further comprising two or more electrical contacts (-) in contact with the shape memory alloy element ().3100107107108109109adae. The valve assembly () of claim 2 , wherein each of the two or more valve members (-) is coupled to the shape memory alloy () between two electrical contacts (-).4100109109108109109107107109109aeaeadae. The valve assembly () of claim 3 , wherein the two or more electrical contacts (-) are energized to thermoelectrically heat a portion of the shape memory alloy () between the two electrical contacts (-) above its transformation temperature to independently actuate the valve members (-) between the two electrical contacts (-) towards the second position.5100105105107107adad. The valve assembly ...

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Номер записи: 71
16-01-2020 дата публикации

Passive Micro-vessel and Sensor

Номер: US20200018152A1
Автор: Angelescu Dan E.
Принадлежит:

An electrically passive device and method for in-situ acoustic emission, and/or releasing, sampling and/or measuring of a fluid or various material(s) is provided. The device may provide a robust timing mechanism to release, sample and/or perform measurements on a predefined schedule, and, in various embodiments, emits an acoustic signal sequence(s) that may be used for triangulation of the device position within, for example, a hydrocarbon reservoir or a living body. 1. A device comprising:an isolated cavity that is initially inaccessible to an external fluid;a device body including one or more structural elements supporting a mechanical structure, the mechanical structure separating the isolated cavity from the external fluid;a piercing structure for piercing the mechanical structure; anda membrane, wherein pressure applied to the membrane drives the piercing structure into the mechanical structure, causing the mechanical structure to collapse, rupture and/or fracture, opening a passage for the external fluid to enter the isolated cavity.2. The device according to claim 1 , wherein the isolated cavity is in fluidic communication with a sampling chamber.3. The device according to claim 2 , further comprising a tube coupled to the isolated cavity claim 2 , the tube further coupled to a sampling chamber such that external fluid from the isolated cavity can flow into the sampling chamber.4. The device according to claim 1 , further including a one-way check valve between the isolated cavity and the sampling chamber that allows fluid flow into the sampling chamber.5. The device according to claim 1 , further comprising an electrically passive timing mechanism including a fluidic timing cavity claim 1 , wherein at the end of a timing interval fluid within the timing cavity drives the piercing structure into the mechanical structure claim 1 , causing the mechanical structure to collapse claim 1 , rupture and/or fracture.6. The device according to claim 5 , wherein the ...

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Номер записи: 72
21-01-2021 дата публикации

MICRO PUMP

Номер: US20210017976A1
Автор: CHEN SHIH-CHANG, Han Yung-Lung, Huang Chi-Feng, Kao Chung-Wei, Lee Wei-Ming, Liao Hung-Hsin, Liao Jia-Yu, Mou Hao-Jan, Tsai Chang-Yen
Принадлежит: Microjet Technology Co., Ltd.

A micro pump is disclosed and includes a fluid-converging plate, a valve membrane, a fluid-outlet plate and a pump core module. The fluid-converging plate includes an inner recess, a protruding portion and a fluid-converging aperture. The protruding portion is disposed at a center of the inner recess. The valve membrane includes a valve aperture. The protruding portion of the fluid-converging plate abuts against the valve aperture. A fluid-converging chamber is formed between the valve membrane and the fluid-converging plate. The fluid-outlet plate in a ring shape includes a fluid-outlet channel. The valve aperture is in fluid communication with the fluid-outlet channel. When the fluid is inhaled into the pump core module, the fluid flows to the fluid-converging chamber through the fluid-converging aperture and then pushes out the valve membrane to flow into the fluid-outlet channel of the fluid-outlet plate through the valve aperture. Thereby the fluid transportation is achieved. 1. A micro pump comprising: an outer groove disposed on the first surface;', 'an inner recess disposed on the first surface and surrounded by the outer groove; a protruding portion disposed on the first surface and located at a center of the inner recess;', 'at least one fluid-converging aperture disposed in the inner recess and adjacent to an outer edge of the protruding portion, wherein the fluid-converging aperture penetrates the first surface and the second surface of the fluid-converging plate; and', 'a fluid-converging peripheral wall disposed on the second surface of the fluid-converging plate to define a fluid-converging space;, 'a fluid-converging plate having a first surface and a second surface, wherein the first surface and the second surface are two opposite surfaces, and the fluid-converging plate comprisesa valve membrane disposed in the inner recess of the fluid-converging plate and comprising a valve aperture disposed at a center of the valve membrane, wherein the ...

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Номер записи: 73
22-01-2015 дата публикации

DEVICE WITH ROTARY VALVE FOR THE MANIPULATION OF LIQUIDS

Номер: US20150020904A1
Автор: Böttcher Heiko, Gärtner Claudia, Klemm Richard
Принадлежит: MICROFLUIDIC CHIPSHOP GmbH

The present invention describes a device consisting of a rotor, a holding-down device, and a base plate. The base plate is normally a fluidic system, a planar fluidic system for example or a fluidic system with several fluidic ports for a directed guidance of liquids or gases through different channels, channel systems, cavities or tubing, for the combination liquid and gas streams, or for prevention of liquid flows. 1. A system consisting of a rotor located inside of a holding-down device , said rotor will be being pressed onto a base plate by a by the holding-down device , wherein the base plate possesses openings from one or more channels , which open out into fluidic structures of the rotor mounted on the base plate , in order to guarantee a directed flow of liquids or gases in different channels , channel systems , cavities , or tubing , to facilitate their coupling or to inhibit any flow of liquids or gases.21. The system of , in which the base plate is a fluidic or microfluidic system and the holding-down device is formed like a cap and presses the rotor tightly onto the counter structure of the base plate.3. The system of claim 1 , in which the rotor is mounted between to plates claim 1 , which press him with sufficiently high initial tensions against the counter structure of one plate resulting in a microfluidic system with several layers.4. The system of claim 1 , in which the rotor is mounted between to plates claim 1 , which press him with sufficiently high initial tensions against the counter structure of one plate resulting in a microfluidic system with several layers and resulting in a rotor with through holes or slits claim 1 , and claim 1 , as a consequence claim 1 , giving rise to a system claim 1 , where openings from channels of the lower plate can be connected with openings from channels of the upper plate via the rotor.5. The system of in which at least one additional structured plate is added resulting in a system with multiple layers claim 3 ...

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Номер записи: 74
21-01-2021 дата публикации

Membraneless fluidic devices

Номер: US20210018102A1
Автор: Andrew Arthur Stanley, Casey Glick, Erik Samuel Roby, Serol Turkyilmaz
Принадлежит: Facebook Technologies LLC

Example devices include a fluidic device, such as a fluidic valve, including a body formed from a rigid body material including a fluidic source, a fluidic drain, and a fluidic gate, each of which may have a fluid connection with a chamber, or a portion thereof. The device may further include a gate transmission element, located within the chamber, that is controllable between at least a first position and a second position using a gate pressure received through the fluidic drain. Adjustment of the position of the gate transmission element may allow control of fluid flow through the device. Other devices, methods, systems, and computer-readable media are also disclosed.

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Номер записи: 75
21-01-2021 дата публикации

CHANNEL CHIP

Номер: US20210018104A1
Автор: Ono Koichi, SUNAGA Nobuya
Принадлежит:

A channel chip having a channel for running a fluid that is opened and closed by sliding on a film a sliding member slidable on the film while contacting with the film, the channel chip comprising: a substrate including a first channel, a second channel and a partition wall formed between the first channel and the second channel; a film including a diaphragm having a substantially spherical crown shape, the film being disposed on the substrate so that the diaphragm faces the partition wall; and a positioning section for holding the sliding member in such a way that the sliding member is slidable on the film while the positioning section positions the sliding member, the positioning section being disposed on the film. 1. A channel chip having a channel for running a fluid that is opened and closed by sliding on a film a sliding member slidable on the film while contacting with the film , the channel chip comprising:a substrate including a first channel, a second channel and a partition wall formed between the first channel and the second channel;a film including a diaphragm having a substantially spherical crown shape, the film being disposed on the substrate so that the diaphragm faces the partition wall; anda positioning section for holding the sliding member in such a way that the sliding member is slidable on the film while the positioning section positions the sliding member, the positioning section being disposed on the film.2. The channel chip according to claim 1 , wherein the sliding member is a rotary member which is rotatable.3. The channel chip according to claim 1 , wherein the positioning section is a frame for holding the sliding member in such a way that the sliding member is slidable on the film. This application is a continuation of U.S. patent application Ser. No. 16/324,179, filed on Feb. 8, 2019, which is National Stage Application of International Application No. PCT/JP2017/028175, filed on Aug. 3, 2017, the disclosure of which, including the ...

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Номер записи: 76
16-01-2020 дата публикации

Diaphragm valves, valve components, and methods for forming valve components

Номер: US20200018421A1
Автор: John Shugrue
Принадлежит: ASM IP Holding BV

A diaphragm valve is disclosed. The diaphragm valve may include, a valve body comprising a valve channel, the valve channel including an inlet channel and an outlet channel. The diaphragm valve may also include, a valve seat adjacent to the valve channel and a flexible diaphragm comprising a wetted surface and an opposing non-wetted surface, the flexible diaphragm being disposed adjacent to the valve channel. The diaphragm valve may also include, a flexible heater disposed over the non-wetted surface of the flexible diaphragm, and a valve actuator that is operable to operable to move the wetted surface of the flexible diaphragm into and out of contact with the valve seat. Valve components including a flexible heater and methods for forming such valve components are also disclosed.

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Номер записи: 77
22-01-2015 дата публикации

Fluid handling device and fluid handling method

Номер: US20150021501A1
Автор: Ken Kitamoto, Koichi Ono
Принадлежит: Enplas Corp

A micro fluid chip includes a first chip and a second chip. The first chip includes a first substrate having a fluid channel and a partition wall, and a first film made of resin. The second chip includes a second substrate having a recess, and a second film made of elastomer. The second film has an elastic modulus higher than that of the first film. The first chip and the second chip are stacked in such a manner that the partition wall and the recess face each other with the first film and the second film therebetween. By setting the inner side of the recess to a negative pressure, a gap is formed between the first film and the partition wall, and thus a fluid channel is opened.

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Номер записи: 78
22-01-2015 дата публикации

MICROFLUIDIC DEVICES WITH MECHANICALLY-SEALED DIAPHRAGM VALVES

Номер: US20150021502A1
Автор: Vangbo Mattias
Принадлежит:

This invention provides a fluidic device comprising a diaphragm valve having a fluidics layer, an actuation layer and an elastic layer between the fluidics layer and the actuation layer, the elastic layer having a diaphragm that is mechanically sealed against the fluidics layer and the actuation layer by a sealing ring in the actuation layer. 13-. (canceled)4. A device comprising at least one diaphragm valve comprised in a combination that comprises a fluidics layer , an actuation layer and an elastic layer sandwiched between the fluidics layer and the actuation layer , wherein a diaphragm in each diaphragm valve is comprised in the elastic layer and is mechanically sealed against the fluidics layer and against the actuation layer by a raised sealing ring in the actuation layer.5. (canceled)6. The device of claim 4 , further comprising a mechanical fastener configured to fasten the combination into a sandwich claim 4 , wherein the mechanical fastener transmits pressure to a pressure seal.7. The device of claim 6 , wherein the mechanical fastener is selected from a screw claim 6 , a clip claim 6 , a snap claim 6 , a staple claim 6 , a rivet claim 6 , a band and a pin.8. The device of claim 4 , wherein the elastic layer comprises a urethane claim 4 , a nitrile claim 4 , a latex or silicone.9. The device of claim 4 , wherein the at least one diaphragm valve is a plurality of diaphragm valves.10. The device of claim 4 , wherein each diaphragm valve comprises:a) a valve seat against which the diaphragm is configured to sit;b) a valve relief defined at least in part by the sealing ring into which the diaphragm is configured to be deflected, thereby defining a valve chamber; andc) a valve inlet and a valve outlet comprised in the fluidics layer and in fluid communication with the valve chamber,wherein the diaphragm is configured to be actuated by positive or negative pressure transmitted through an actuation conduit in the actuation layer that communicates with the valve ...

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Номер записи: 79
10-02-2022 дата публикации

METHOD AND APPARATUS FOR THE FAIL-SAFE TERMINATION OF IN VIVO DRUG DELIVERY FROM AN IMPLANTABLE DRUG DELIVERY SYSTEM

Номер: US20220040406A1
Автор: Farina Marco, Grattoni Alessandro, Hood Robert Lyle
Принадлежит:

A method for the fail-safe termination of in vivo drug delivery from an implantable drug delivery system, the method comprising: providing an implantable drug delivery system comprising: a housing having a reservoir for containing a drug, and a port for dispensing the drug to a patient; and an emergency deactivation unit disposed between the reservoir and the port, the emergency deactivation unit comprising a composite structure comprising a biocompatible ferromagnetic mesh open to fluid flow and a hydrophobic meltable material, the hydrophobic meltable material comprising at least one hole therein for enabling a fluid to pass through the hydrophobic meltable material; implanting the implantable drug delivery system within a patient; enabling the drug to flow from the reservoir, through the at least one hole in the hydrophobic meltable material and out the port; and when drug flow is to be terminated, applying a magnetic field to the composite structure, such that a current is induced in the ferromagnetic mesh which heats the ferromagnetic mesh and melts the hydrophobic meltable material, thereby closing the at least one hole in the hydrophobic meltable material and blocking drug delivery to the patient. 128.-. (canceled)29. A method for the fail-safe termination of fluid flow through a fluid pathway , the method comprising: 'a barrier element comprising a hydrophobic material having a solid state at physiological temperature and a flowable state above physiological temperature, the barrier element comprising an opening extending therethrough for allowing fluid to pass through the barrier element;', 'providing an emergency deactivation unit comprisingpositioning the emergency deactivation unit within the fluid pathway;enabling fluid to flow from one side of the emergency deactivation unit, through the opening in the barrier element, to the other side of the emergency deactivation unit; andwhen fluid flow is to be terminated, increasing the temperature of the barrier ...

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Номер записи: 80
25-01-2018 дата публикации

MICROFLUIDIC OSCILLATOR PUMP

Номер: US20180023552A1
Автор: Duncan Philip N., Hui Elliot En-Yu, Nguyen Transon V.
Принадлежит:

Microfluidic oscillator circuits and pumps for microfluidic devices are provided. The microfluidic pump may include a plurality of fluid valves and a microfluidic oscillator circuit having an oscillation frequency. The fluid valves may be configured to move fluids. Each fluid valve may be connected to a node of the microfluidic oscillator circuit. The pumps may be driven by the oscillator circuits such that fluid movement is accomplished entirely by circuits on a microfluidic chip, without the need for off-chip controls. 1400. A pump () comprising:{'b': 350', '302', '304', '306', '350, 'claim-text': [{'b': 312', '314', '316, '(i) an odd number of three or more pneumatic or hydraulic inverter logic gates (,,), herein referred to as inverter logic gates, wherein an application of higher pressure at an input of an inverter logic gate results in lower pressure at an output of said inverter logic gate, wherein an application of lower pressure at the input of an inverter logic gate results in higher pressure at the output of said inverter logic gate; and'}, {'b': '300', '(ii) one or more logic channels (), wherein the inverter logic gates are arranged in a ring configuration, wherein the output of each inverter logic gate is operatively connected by a logic channel to the input of a next inverter logic gate, wherein the output of a last inverter logic gate is operatively connected to the input of a first inverter logic gate; and'}], '(a) a ring oscillator circuit () producing a plurality of pressure oscillations for driving a plurality of out-of-phase expansions and contractions of a plurality of valves (,,), arranged in series, to drive a net transport of a gas or liquid, wherein two or more pressure oscillations are phase shifted relative to one another by a value not equal to 180 degrees to create asymmetry, the ring oscillator circuit () comprising{'b': '330', '(b) a plurality of fluid channels () effective for a coordinated movement of a flow of the gas or liquid ...

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Номер записи: 81
25-01-2018 дата публикации

FLUID-BASED GATING MECHANISM WITH TUNABLE MULTIPHASE SELECTIVITY AND ANTIFOULING BEHAVIOR

Номер: US20180023728A1
Автор: Aizenberg Joanna, HOU Xu, KHAN Mughees, TESLER Alexander
Принадлежит:

A gating mechanism that uses a capillary stabilized liquid as a reversible, reconfigurable gate that fills and seals pores in the closed state, and creates a non-fouling, liquid-lined pore in the open state is disclosed. Theoretical modeling and experiments demonstrate that for each transport substance, the gating threshold—the pressure needed to open the pores—can be rationally tuned over a wide pressure range. This enables realizing in one system differential response profiles for a variety of liquids and gases, even letting liquids flow through the pore while preventing gas from escaping. These capabilities allow dynamic modulation of gas-liquid sorting and to separate multi-phase mixtures, with the liquid lining ensuring sustained antifouling behavior. Because the liquid gating strategy enables efficient short-term and long-term operation and can be applied to a variety of pore structures and membrane materials, and to nano, micro as well as macroscale fluid systems, the gating systems is useful in a wide range of applications. 1. A gating membrane device comprising:a membrane comprising a plurality of pores, wherein at least one pore of said plurality of pores has a continuous path that traverses a thickness of the membrane, the membrane positioned and arranged to permit a transport fluid to traverse the membrane thickness;a wetting liquid filling the at least one pore of said plurality of pores,wherein the wetting liquid partially displaces above a threshold pressure applied across said at least one pore to allow transport of the transport fluid through the membrane while contacting the wetting liquid,wherein the wetting liquid is selected to be immiscible with the transport fluid, andwherein the wetting liquid refills the at least one pore and gate transport of the transport fluid across the membrane below the threshold pressure.2. The gating membrane device of claim 1 , wherein the membrane is a polymer claim 1 , a ceramic claim 1 , a composite or a metal.3. ...

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Номер записи: 82
24-01-2019 дата публикации

DISPOSABLE DIAPHRAGM VALVE

Номер: US20190024822A1
Автор: La Can T., Lam Charles, Martin Lawrence, Parker Andrew, Velinov Mario
Принадлежит:

A valve for dispensing fluid as a bead or a dot having a housing with an internal cavity and a disposable insert positioned within the cavity of the housing having a fluid inlet, a fluid chamber, a fluid outlet and a diaphragm adjacent the fluid chamber between the fluid inlet and the fluid outlet. The replaceable insert further has a latching mechanism adjacent the diaphragm for receipt of a reciprocating actuator to actuate the diaphragm to dispense fluid from the fluid chamber. 1. A method of using a fluid dispensing valve assembly , comprising:based on user input, a disposable diaphragm valve insert being inserted into an internal cavity of a housing of a fluid dispensing valve assembly, the disposable diaphragm valve insert having interior surfaces which come into contact with a dispensing fluid;receiving fluid into a fluid chamber in the disposable diaphragm valve insert,a diaphragm within the disposable diaphragm valve insert being engaged and disengaged by a reciprocating actuator to move the diaphragm through the fluid chamber;dispensing the fluid when the actuator is disengaged with the diaphragm;based on user input, the disposable diaphragm valve insert being replaced, as an assembled unit, with a different disposable diaphragm valve insert, as an assembled unit.2. The method of claim 1 , wherein the step of receiving fluid into the disposable diaphragm valve insert includes receiving fluid under pressure through a valve inlet into the fluid chamber in the disposable diaphragm valve insert.3. The method of claim 1 , wherein the step of dispensing the fluid is through a fluid outlet connected to the fluid chamber.4. The method of claim 1 , wherein the fluid dispensed is an adhesive claim 1 , epoxy claim 1 , potting compound or solder paste.5. The method of claim 1 , wherein the disposable diaphragm valve insert further includes a latching mechanism adjacent the diaphragm opposite the fluid chamber.6. The method of claim 2 , wherein the reciprocating ...

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Номер записи: 83
24-01-2019 дата публикации

Fluid delivery device with hydrophobic surface

Номер: US20190024823A1
Автор: Steven L. Wright, Yang Liu
Принадлежит: International Business Machines Corp

Embodiments of the present invention are directed to a liquid delivery apparatus. A non-limiting example of the apparatus includes a substrate including a cavity formed in a surface of the substrate. The apparatus can also include a membrane disposed on the surface of the substrate covering an opening of the cavity. The apparatus can also include a hydrophobic layer disposed on the membrane. The apparatus can also include a seal disposed between the membrane and the substrate, wherein the seal surrounds the opening of the cavity. The apparatus can also include an electrode layer coupled to the membrane.

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Номер записи: 84
29-01-2015 дата публикации

VALVE, MICROFLUIDIC DEVICE, MICROSTRUCTURE, VALVE SHEET, METHOD OF MANUFACTURING VALVE SHEET, AND METHOD OF MANUFACTURING MICROFLUIDIC DEVICE

Номер: US20150028235A1
Автор: ICHIKI Takanori, SHIONO Hirofumi, TAKEHARA Hiroaki
Принадлежит:

Provided is a valve formed of a shape-memory polymer disposed in a flow channel, in which a flow of fluid in the flow channel is adjusted by deformation of the valve. 1. A valve formed of a shape-memory polymer disposed in a flow channel ,wherein a flow of fluid in the flow channel is adjusted by deformation of the valve.2. The valve according to claim 1 ,wherein at least a portion of the shape-memory polymer forms at least a portion of the flow channel.3. The valve according to claim 1 ,wherein the valve is configured to be deformed to an open state in which the fluid flows through the flow channel or to a closed state in which the flow of the fluid is blocked, depending on the temperature change.4. The valve according to claim 1 ,wherein the shape-memory polymer film is deformed to an open state in which the fluid flows through the flow channel or to a closed state in which the flow of the fluid is blocked, depending on the temperature change.5. The valve according to claim 1 ,wherein the valve is a normally open valve which is deformed from an open state in which the fluid flows through the flow channel to a closed state in which the flow of the fluid is blocked, by being heated.6. The valve according to claim 1 ,wherein the valve is a normally closed valve which is deformed from a closed state in which the flow of the fluid in the flow channel is blocked to an open state in which the fluid flows through the flow channel by being heated.7. The valve according to claim 1 ,wherein the valve is a series valve formed by disposing a normally closed valve, of which the state is deformed from a closed state in which the flow of the fluid in the flow channel is blocked to an open state in which the fluid flows through the flow channel by being heated, and a normally open valve, of which the state is deformed from the open state in which fluid flows through the flow channel to the closed state in which the flow of the fluid is blocked by being heated, in series.8. The ...

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Номер записи: 85
23-01-2020 дата публикации

VALVE WITH ENERGY-SAVING ELECTRODYNAMIC ACTUATOR

Номер: US20200025307A1
Автор: Baumann Johannes, EGNER Ralf, Klaiber Markus, Kuenzler Rainer, Mohs Patrick, SCHEIBE Ralf
Принадлежит:

A valve includes an electrodynamic actuator which has a magnet arrangement for generating a magnetic field and a control element movable relative to the magnet arrangement. The control element includes an energizable coil which is arranged in the magnetic field and is firmly coupled to a coil carrier. The control element is movable between at least two defined positions. There are provided permanent-magnetically interacting holding force which retain the control element in at least one of the defined positions, even when the coil is currentless. 1: A valve , comprising an electrodynamic actuator which includesa magnet arrangement for generating a magnetic field, anda control element movable relative to the magnet arrangement,wherein the control element includes an energizable coil which is arranged in the magnetic field and is firmly coupled to a coil carrier,wherein the control element is movable between at least two defined positions, andwherein permanent-magnetically interacting holding force are provided, which retain the control element in at least one of the defined positions, even when the coil is currentless.2: The valve according to claim 1 , wherein the permanent-magnetically interacting holding force include a soft-magnetic part which is firmly coupled to the control element at least in the direction of movement of the control element and interacts with the magnetic field of the magnet arrangement.3: The valve according to claim 2 , wherein the soft-magnetic part is configured as at least one of the following: wire claim 2 , a plurality of wire pieces claim 2 , a plurality of balls claim 2 , a rod claim 2 , a sheet metal strip claim 2 , soft-magnetic powder claim 2 , soft-magnetic chips claim 2 , a plastic part filled with soft-magnetic material.4: The valve according to claim 2 , wherein the magnetic field generated by the magnet arrangement includes a magnetic field area of different flux density (B) claim 2 , wherein the soft-magnetic part is arranged ...

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Номер записи: 86
23-01-2020 дата публикации

LOW FORCE VALVES FOR DRUG DELIVERY PUMPS

Номер: US20200025310A1
Автор: Allis Daniel, MCLAUGHLIN Ian
Принадлежит:

Disclosed are examples of valve systems and methods of operating the respective valve systems. An example valve system may include a valve body, an inlet component, an outlet component and a valve tube. The valve body may include a first void and a second void. The inlet component may be coupled to the first void and the outlet component may be coupled to the second void. The valve tube may include a side port and may be positioned through the valve body and coupled to the first void, the inlet component, the second void, and the outlet component. Other valve system examples may include including a valve body, a first septum, a second septum, a first piston, a second piston and a tube. The disclosed methods describe the interaction of the respective components of the respective valve system example. 1. A valve system , comprising:a valve body comprising a first void and a second void;an inlet component coupled to the first void;an outlet component coupled to the second void;a valve tube positioned through the valve body and coupled to the first void, the inlet component, the second void, and the outlet component, the valve tube comprising a side port.2. The valve system of claim 1 , wherein the valve system comprises a low actuation force claim 1 , micro claim 1 , no fluid displacement valve.3. The valve system of claim 1 , wherein the inlet component is coupled to a reservoir storing a fluid.4. The valve system of claim 1 , wherein the outlet component is coupled to a fluid path component coupled to a patient.5. The valve system of claim 4 , wherein the fluid path component comprises a cannula.6. The valve system of claim 1 , wherein the valve system is configured to be coupled to a pump head.7. The valve system of claim 6 , wherein the pump head comprises a pump piston and a pump chamber claim 6 , wherein the valve tube is coupled to the pump chamber.8. The valve system of claim 7 , wherein during a first stage of operation claim 7 , the side port is aligned with ...

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Номер записи: 87
23-01-2020 дата публикации

THREE-WAY MICROVALVE DEVICE AND METHOD OF FABRICATION

Номер: US20200025311A1
Автор: Huff Michael A.
Принадлежит:

A three-way (3-way) Micro-Electro-Mechanical Systems (MEMS)-based micro-valve device and method of fabrication for the implementation of a three-way MEMS-based micro-valve are disclosed. The micro-valve device has a wide range of applications, including medical, industrial control, aerospace, automotive, consumer electronics and products, as well as any application(s) requiring the use of three-way micro-valves for the control of fluids. The discloses three-way micro-valve device and method of fabrication that can be tailored to the requirements of a wide range of applications and fluid types, and can also use a number of different actuation methods, including actuation methods that have very small actuation pressures and energy densities even at higher fluidic pressures. This is enabled by a novel pressure-balancing scheme, wherein the fluid pressure balances the actuator mechanism so that only a small amount of actuation pressure (or force) is needed to switch the state of the actuator and device from open to closed, or closed to open. 1. A method of fabricating a three-way pressure-balanced micro-valve device , the method comprising:providing a bottom substrate,micomachining the bottom substrate so as to form in the bottom substrate a bottom fluid chamber having a depth extending partially into the bottom substrate,forming in the bottom substrate at least one fluid port that passes completely through the bottom substrate, so as to fluidically connect to the bottom fluid chamber,providing a top substrate,micomachining the top substrate so as to form in the top substrate a top fluid chamber having a depth extending partially into the top substrate, andforming in the bottom substrate at least at least one fluid port that passes completely through the bottom substrate so as to fluidically connect to the bottom fluid chamber, andproviding a middle substrate, andthinning the middle substrate so as to be a membrane layer in the region of where the fluid chamber is ...

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Номер записи: 88
23-01-2020 дата публикации

CENTRIFUGAL VALVE CONTROL APPARATUS

Номер: US20200025312A1
Автор: KIM Min Seok
Принадлежит:

Provided is a centrifugal valve control apparatus including: a body part including a body having a chamber and a channel connected to the chamber, and a valve configured to open and close the channel; a heating part coupled to the body and including a heating member disposed at a position corresponding to the valve; and a rotation driving part configured to rotate the body part and the heating part together, wherein the valve is formed to open and close the channel by the heating member while the body part and the heating part rotate together. Accordingly, the valve of the centrifugal valve control apparatus may be accurately controlled. 1. A centrifugal valve control apparatus comprising:a body part including a body having a chamber and a channel connected to the chamber, and a valve configured to open and close the channel;a heating part coupled to the body, and including a heating member disposed at a position corresponding to the valve; anda rotation driving part configured to rotate the body part and the heating part together,wherein the valve is formed to open and close the channel by the heating member while the body part and the heating part rotate together.2. The centrifugal valve control apparatus of claim 1 , wherein:the body is formed of a tube having a predetermined height; andthe heating part is formed of a substrate.3. The centrifugal valve control apparatus of claim 1 , wherein:each of the chamber and the channel is provided in the body.4. The centrifugal valve control apparatus of claim 1 , wherein:the valve is provided in the body; andthe heating member is provided at a lower part of the heating part.5. The centrifugal valve control apparatus of claim 1 , further comprising a battery configured to supply power to the heating member.6. The centrifugal valve control apparatus of claim 1 , wherein:the channel and the valve formed in the channel are provided in plural in the body; andthe heating members corresponding to the valves are provided in the ...

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Номер записи: 89
02-02-2017 дата публикации

MICROFLUIDICS MODULE AND CARTRIDGE FOR IMMUNOLOGICAL AND MOLECULAR DIAGNOSIS IN AN ANALYSIS MACHINE

Номер: US20170028403A1
Автор: KRAUSE Ulrich
Принадлежит:

The invention relates to a microfluidics module () for both the immunological and molecular diagnosis of samples, wherein channels () and/or cavities () having inlets (-) for fluid samples and reagents, as well as inlet-assigned containers, container receiving means or container anchoring points are formed in a main body, and which module has a detection channel (), for receiving a test-specific detection medium, that can be connected with channels () of the module. A central multi-port valve () is essential for the function, and controllably connects individual channels () on the module. The channels belong to channel structures which are assigned certain functions and which are all directly or indirectly connected to the multi-port valve (), wherein at least sections of the channel structures and channels form circuits (), the channels () and/or cavities () of which circuits are at least partially arranged close to the base surface (), in order to permit procedures, controlled by the analysis device, within the test process. The invention also relates to a cartridge () for receiving a microfluidics module (), a reagent module (), and a method for carrying out both immunological and, optionally, molecular tests using the microfluidics module (). 1. A microfluidics module configured both for the immunological and molecular diagnostics of samples , in which channels and/or cavities having inlets for fluid samples and reagents , are configured in a base body , wherein containers , container accommodators or container attachment points are assigned to the inlets , and a detection channel for accommodating an assay-specific detection means connected or connectable to channels of the module , comprising:exactly one multiport valve which connects individual channels;channel structures including i) at least channels and/or cavities for sample guidance which include conditioning necessary for certain assays, ii) channels for reagent feeding, iii) a channel structure with ...

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Номер записи: 90
04-02-2016 дата публикации

MICRO VALVE DEVICE AND VALVE BODY ASSEMBLY

Номер: US20160033055A1
Автор: Zhang Shengchang
Принадлежит:

Provided are a micro valve device and a valve body assembly. The micro valve device comprises at least two control ports () and at least two movable members (), wherein the at least two movable members () respectively control each of the at least two control ports () to realize that opening and closing of the control ports () are independently controlled, so that the at least two control ports () can output fluids with the same or different flow rate(s) or pressure(s). The valve body assembly comprises the micro valve device. 1. A micro valve device , comprising:a main body, defining a chamber, the main body having a source port and at least two control ports which are in communication with the chamber;at least two movable members, the at least two movable members independently controlling conduction or blocking between each of the at least two control ports and the source port by switching between a first position and a second position, respectively,wherein, upon each movable member being located in the first position, a corresponding control port is in fluid communication with the source port through at least a portion of the chamber; and upon each movable member being located in the second position, a fluid path between a corresponding control port and the source port is blocked by the movable member.2. The micro valve device according to claim 1 , wherein the at least two control ports output fluids having different flow rates and pressures claim 1 , by independently controlling movement of each of the at least two movable members.3. The micro valve device according to claim 1 , wherein the main body includes a base layer claim 1 , an intermediate layer and a cover layer stacked sequentially claim 1 , wherein the intermediate layer is of a frame structure claim 1 , so as to define the chamber with the base layer and the cover layer.4. The micro valve device according to claim 1 , wherein the main body further includes at least one back-flow port claim 1 , and ...

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Номер записи: 91
30-01-2020 дата публикации

MICROFLUIDICS VALVE

Номер: US20200030799A1
Автор: BALDI COLL Antonio, DÍAZ GONZÁLEZ María, FERNÁNDEZ SÁNCHEZ César, MUÑOZ BERBEL Francesc Xavier
Принадлежит:

A microfluidics valve comprises at least two substrates () between which there is at least a microchannel (). It additionally comprises at least a barrier () of a meltable material, placed in the microchannel. The valve further comprises at least an optical heater () placed in correspondence with the barrier () and at least a section of one of the substrates (), in correspondence with the optical heater (), is transparent. The optical heater is a colored line that, when is illuminated with a light source, is heated and releases the heat to the barrier () thus melting the part of it that is closer to the line. 2614. Microfluidics valve according to characterized in that the optical heater () is placed in one of the substrates () and is facing the barrier ().364. Microfluidics valve according to characterized in that the optical heater () is in contact with the barrier ().46. Microfluidics valve according to characterized in that the optical heater () is a feature made of a photothermal material that can absorb light energy in a range of frequencies.561. Microfluidics valve according to characterized in that the optical heater () is a printed dark colored line placed in one of the substrates ().6356. Microfluidics valve according to characterized in that one of the substrates comprises at least a hole () in correspondence with the microchannel () and facing the optical heater ().765496. Microfluidics valve according to characterized in that it comprises a first optical heater () placed in the microchannel () in correspondence with the barrier () and at least an additional optical heater () placed in one side of the first optical heater ().896. Microfluidics valve according to characterized in that it comprises two additional optical heaters () placed each at one side of the first optical heater ().994. Microfluidics valve according to characterized in that the additional optical heaters () do not project out of the barrier () at any point.10. Microfluidics valve ...

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Номер записи: 92
30-01-2020 дата публикации

MICROCHIP CONTROLLING SYSTEM

Номер: US20200030801A1
Автор: IIMURA Yasuo
Принадлежит: NEC Corporation

A microchip controlling system comprises a microchip which is configured by adhesion of an elastic sheet and a plate/sheet member, and on which a flow path is provided as an inadhesive section between the elastic sheet and the plate/sheet member; and a microchip controlling apparatus comprising a valve mechanism which is inflated or deflated so as to control the flow path to be opened or closed. 1. A microchip controlling system , comprising:a microchip which is configured by adhesion of an elastic sheet and a plate/sheet member, and on which a flow path is provided as an inadhesive section between the elastic sheet and the plate/sheet member; anda microchip controlling apparatus comprising a valve mechanism which is inflated or deflated so as to control the flow path to be opened or closed.2. The microchip controlling system of claim 1 , whereinthe valve mechanism is configured with at least two plates and an elastic sheet sandwiched by the plates,a first plate has a cut out section at a position to be directed to the flow path,a second plate has a groove section at a position corresponding to the cut out section,the flow path is brought into an opened state when the elastic sheet of the microchip enters the cut out section,the flow path is brought into a closed state when the elastic sheet of the valve mechanism is shoved into the cut out section due to expansion of the groove section by injection of pressurizing medium and pushes out the elastic sheet of the microchip from the cut out section.3. The microchip controlling system of claim 1 , whereinthe valve mechanism comprises a plate having a groove section at a position to be directed to the flow path,the flow path is brought into an opened state when the elastic sheet of the microchip enters the groove section, and brought into a closed state when the elastic sheet of the microchip is pushed out from the groove section due to injection of a pressurizing medium.4. The microchip controlling system of claim 1 , ...

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Номер записи: 93
04-02-2021 дата публикации

FLUID HANDLING DEVICE AND FLUID HANDLING SYSTEM

Номер: US20210031194A1
Автор: SUNAGA Nobuya, YABUUCHI Satomi, YAMAUCHI Takumi
Принадлежит:

This fluid handling device has a rotary member that is rotatable around the central axis. In the rotary member, a first protruding part for pressing and closing a valve of a flow channel chip and a recessed part for opening the valve without pressing the valve are disposed on the circumference of a first circle around the central axis. The rotary member further has a second protruding part for, when the recessed part is located at the valve in a state where the rotary member is rotated, pressing the valve so as not to open the valve. 1. A fluid handling device configured to control fluid in a channel of a channel chip , a plurality of introduction channels;', 'a common channel connected to the plurality of introduction channels; and', 'a plurality of valves disposed for the plurality of introduction channels, each of the plurality of valves being disposed in each of the plurality of introduction channels or at a connecting portion between each of the introduction channel and the common channel; and, 'wherein the channel chip includes a first protrusion configured to close the plurality of valves by pressing a diaphragm of each of the plurality of valves;', 'a recess configured to open the plurality of valves without pressing the diaphragm of each of the plurality of valves, the first protrusion and the recess being disposed on a circumference of a first circle around the central axis; and', 'a second protrusion configured to close a valve of the plurality of valves that is opposite to the recess by pressing a diaphragm of the valve of the plurality of valves when the recess is located over the valve of the plurality of valves in a state where the rotary member is rotated., 'wherein the fluid handling device includes a rotary member rotatable around a central axis, the rotary member including2. The fluid handling device according to claim 1 , wherein the second protrusion is disposed on a circumference of a second circle disposed around the central axis claim 1 , the ...

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Номер записи: 94
30-01-2020 дата публикации

FLUID DELIVERY DEVICE WITH HYDROPHOBIC SURFACE

Номер: US20200032925A1
Автор: Liu Yang, Wright Steven L.
Принадлежит:

Embodiments of the present invention are directed to a liquid delivery apparatus. A non-limiting example of the apparatus includes a substrate including a cavity formed in a surface of the substrate. The apparatus can also include a membrane disposed on the surface of the substrate covering an opening of the cavity. The apparatus can also include a hydrophobic layer disposed on the membrane. The apparatus can also include a seal disposed between the membrane and the substrate, wherein the seal surrounds the opening of the cavity. The apparatus can also include an electrode layer coupled to the membrane. 1. A liquid delivery apparatus comprising:a substrate comprising a cavity formed in a surface of the substrate;a membrane connected to a hinged structure;a hydrophobic layer disposed on the membrane; anda seal disposed between the membrane and the substrate, wherein the seal surrounds the opening of the cavity.2. The apparatus of claim 1 , wherein at least a portion of the membrane comprises a metal film.3. The apparatus of further comprising a hydrophilic layer disposed on a surface of the cavity opposite the membrane.4. The apparatus of claim 1 , wherein the hydrophobic layer comprises a material selected from the group consisting of fluorocarbon films claim 1 , micro-structured polymers claim 1 , carbon nanotubes claim 1 , electrodeposited metal films claim 1 , oxides claim 1 , oxide composites claim 1 , and patterned films.5. The apparatus of claim 1 , wherein the hydrophobic layer has a thickness of about 1 Angstrom (Å) to about 500 nanometers (nm) claim 1 ,6. The apparatus of further comprising a liquid in the cavity.7. The apparatus of claim 6 , wherein the liquid comprises an active pharmaceutical agent.8. The apparatus of claim 6 , wherein the liquid comprises a microbattery electrolyte.9. The apparatus of claim 6 , wherein the hydrophobic layer lines a portion of the cavity.10. An electronic delivery device comprising:a dispensing array comprising a ...

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Номер записи: 95
17-02-2022 дата публикации

Inertial energy coastdown for electromagnetic pump

Номер: US20220051819A1
Автор: Michael J. Edwards, Robert A. Corbin
Принадлежит: TerraPower LLC

A nuclear reactor is configured with a primary coolant loop for transferring heat away from the nuclear reactor core. In a shutdown event, the primary coolant pump may stop pumping primary coolant through the reactor core, resulting in decay heat buildup within the reactor core. An inertial energy coast down system can store kinetic energy while the nuclear reactor is operating and then release the stored kinetic energy to cause the primary coolant to continue to flow through the nuclear reactor core to remove decay heat. The inertial energy coast down system may include an impeller and a flywheel having a mass. During normal reactor operation, the flowing primary coolant spins up the impeller and flywheel, and upon a shutdown event where the primary coolant pump stops pumping, the flywheel and impeller can cause the primary coolant to continue to flow during a coast down of the flywheel and impeller.

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Номер записи: 96
05-02-2015 дата публикации

Flow regulation in fluidic systems using a phase-change material at system ports

Номер: US20150037784A1
Автор: Rogacs Anita, Santiago Juan G.
Принадлежит:

Control of fluid flow in a fluidic network is provided by controlling phase transitions of a phase-change material between a liquid phase and a non-fluid phase. The phase-change material is disposed at ports of the fluidic network where the fluidic network is in communication with an ambient. This advantageously provides control of pressure-driven flow within the fluidic network without altering properties of fluids within the fluidic network. 1. Apparatus for controlling fluid flow in a microfluidic system , the apparatus comprising:a microfluidic flow network having at least one port where the flow network is in communication with an ambient;a dispenser configured to deliver a phase-change material to at least one of the ports;wherein the apparatus is configured to control a transition of the phase-change material between a liquid phase and a non-fluid phase.2. The apparatus of claim 1 , wherein at least one of the ports is an input/output node where chemical species can enter or leave the flow network.3. The apparatus of claim 2 , wherein the phase-change material is disposed in the input/output node.4. The apparatus of claim 3 , wherein the phase-change material is capable of conformally sealing around a conduit inserted into the input/output node while also controlling pressure-driven flow in the microfluidic flow network.5. The apparatus of claim 4 , wherein the conduit is an electrode which enables electrical transport into and out of the microfluidic system.6. The apparatus of claim 4 , wherein the conduit is a tube which enables species transport into and out of the microfluidic system.7. The apparatus of claim 2 , wherein two or more channels of the flow network are connected to the input/output node.8. The apparatus of claim 7 , wherein the phase-change material seals some but not all of the two or more channels in its non-fluid state.9. The apparatus of claim 7 , wherein the phase-change material seals all of the two or more channels in its non-fluid ...

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Номер записи: 97
12-02-2015 дата публикации

Fluid Triggerable Valves

Номер: US20150040999A1
Автор: Ender YILDIRIM, Paul Vulto, Sebastiaan Johannes TRIETSCH
Принадлежит: UNIVERSITEIT LEIDEN

The present invention relates to a fluid triggerable passive valve for controlling flow of one or more fluids comprising: a volume comprising at least two capillary pressure barriers for respectively pinning a first and second fluid-fluid meniscus, the two capillary pressure barriers dividing the volume in at least three sub volumes, whereby two sub volumes being positioned upstream and one sub volume being positioned downstream with respect to the advancement direction of each respective fluid-fluid meniscus; wherein the capillary pressure barriers are spaced apart such that upon pinning of a first fluid-fluid meniscus on a first capillary pressure barrier and arrival or pinning of a second fluid-fluid meniscus on or at a second capillary pressure barrier, the two menisci touch and thereby coalesce into one fluid-fluid meniscus

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Номер записи: 98
08-02-2018 дата публикации

SYSTEMS AND METHODS FOR THERMALLY ACTUATED FLOW CONTROL

Номер: US20180038513A1
Автор: Baldea Michael, Donahue Melissa, GUPTA Akash, PATTISON Richard
Принадлежит:

Various implementations provide an inherently safer design feature for microchannel reactors that provides temperature control at the individual channel level. This approach relies on bimetallic strips embedded within the combustion channel, forming a thermally-actuated “valve”. Bimetallic strips convert a temperature change into a mechanical displacement. Heating the strip increases its deflection and thereby restricts flow in the combustion channels, which consequently reduces the rate of heat generation. The thermally-actuated valve is not limited to use in microchannel reactors and may be used in other structures for which thermally actuated flow control is desired, according to some implementations. 1. A thermally actuated flow control system comprising:a first linear array of bimetallic strips disposed on a first wall of a channel; anda second linear array of bimetallic strips disposed on a second wall of the channel, the first and second walls being opposite and in a facing relationship with each other relative to an axis of fluid flow through the channel, each bimetallic strip comprises a fixed end and a free end,', 'the fixed ends of the bimetallic strips in the first array are coupled to the first wall,', 'the fixed ends of the bimetallic strips in the second array are coupled to the second wall,', 'each bimetallic strip comprises a first metal strip having a first thermal expansion coefficient and a second metal strip having a second thermal expansion coefficient, the first and second metal strips being fixedly coupled together, and the first thermal expansion coefficient being higher than the second thermal expansion coefficient, wherein the first metal strip is coupled to the wall, and the second metal strip extends towards the axis of fluid flow of the channel, and', 'a deflection of the free ends of the first array of bimetallic strips away from the first wall and the free ends of the second array of bimetallic strips away from the second wall ...

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Номер записи: 99
08-02-2018 дата публикации

SHAPED MEMORY ALLOY (SMA) VALVE ASSEMBLY FOR CONTROLLING PRESSURIZED AIR SUPPLY TO AIR CELLS IN A VEHICLE SEAT

Номер: US20180038514A1
Автор: Kuszneruk Piotr, Malek Krystof, Szrom Marcin, Truszkowski Tomasz
Принадлежит:

A shaped memory alloy (SMA) valve assembly includes a plurality of SMA valves and a main printed circuit board carrying electronic components and conductors for operating the SMA valves. Each SMA valve includes a pressure chamber having a port. Each pressure chamber contains a valve element biased to a rest position in sealing abutment on a valve seat of the port, a SMA actuator, and an actuator printed circuit board for mounting and electrically connecting the SMA actuator. Each actuator printed circuit board portion is connected to the main printed circuit board portion by a bridge printed circuit board portion, and each pressure chamber has an opening to allow a respective bridge printed circuit board portion to extend therethrough. The opening is provided with a pocket filled with cured sealing glue to embed the bridge printed circuit board portion extending therethrough and to seal the opening of the pressure chamber. 1. A shaped memory alloy (SMA) valve assembly for controlling pressurized air supply to inflatable cells in a vehicle seat , comprising: a pressure chamber having a port, each pressure chamber containing: a valve element biased to a rest position in sealing abutment on a valve seat of the port, a SMA actuator adapted to, when activated by supply of electrical energy, move the valve element away from the valve seat, and an actuator printed circuit board for mounting and electrically connecting the SMA actuator;', 'a conductor arrangement electrically connecting the actuator printed circuit boards inside of the pressure chambers to the main printed circuit board disposed in the housing outside the pressure chambers;', 'wherein the actuator printed circuit boards and the main printed circuit board form part of a common printed circuit board carrying the conductor arrangement, wherein each actuator printed circuit board portion is connected to the main printed circuit board portion by a bridge printed circuit board portion, and in that each pressure ...

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Номер записи: 100