MEMBRANPUMPE MIT DEHNBARER PUMPENMEMBRAN

Mikrofluidischer Aktor, Aktorverfahren und Verfahren zum Herstellen eines Mikroaktors

Die vorliegende Erfindung betrifft einen Mikroaktor und ein Verfahren zum Herstellen eines Mikroaktors zum Bewegen eines Fluids und zur Steuerung der Bewegung eines Fluids sowie ein Verfahren zum Bewegen eines Fluids und zur Steuerung der Bewegung eines Fluids mit einem Mikroaktor mit einer zumindest teilweise Wasser enthaltenden Aktorflüssigkeit. Es ist die Aufgabe der vorliegenden Erfindung, einen Mikroaktor, ein Verfahren zum Bewegen eines Fluids und zur Steuerung der Bewegung eines Fluids mit einem Mikroaktor sowie ein Herstellungsverfahren für einen Mikroaktor zur Verfügung zu stellen, mit welchen ein Aktorprinzip unter Erzeugung von Gasblasen genutzt werden kann und dennoch die für die Umsetzung des Aktorprinzips notwendigen Aktorkomponenten in dem Mikroaktor integrierbar sind. Die erfindungsgemäße Aufgabe wird durch einen Mikroaktor der oben genannten Gattung gelöst, bei welchem die Aktorflüssigkeit in einem flüssigkeitsabsorbierenden Material eingebracht ist. Die Aufgabe der Erfindung ...

Microminiature fluid flow device

Spring-less multi-position micro-fluidic valve assembly

A NORMALLY CLOSED INSTALLATION MICRO CHECK VALVE

MICROMECHANICAL ELEMENTS

PHOTO-HARDENABLE PERFLUORPOLYETHER FOR USE AS NEW MATERIALS IN MICRO-FLUID DEVICES

DEVICE FOR THE MONITORING OF THE RIVER RATE

MICRO VALVE.

VALVE WITH POSITION DETECTOR AND WITH IT MISTAKE MICRO PUMP.

VALVE, METHOD FOR PRODUCTION DISES OF VALVE AND WITH THIS VALVE MISTAKE MICRO PUMP.

THERMAL MICRO VALVES

POLYMER VALVES

VALVE ASSEMBLY FOR MICROFLUIDIC DEVICES, AND METHOD FOR OPENING AND CLOSING SAME

MICROFLUIDIC SYSTEM INCLUDING A BUBBLE VALVE FOR REGULATING FLUID THROUGH A MICROCHANNEL

Micro-machined device for fluids and method of manufacture

REMOTE VALVING FOR MICROFLUIDIC FLOW CONTROL

A method of controlling fluid flow within a microfluidic circuit (10) using external valves and pumps connected to the circuit (10) is disclosed. The external valves and pumps, which are not a part of the microfluidic substrate (11), control fluid pumping pressure and the displacement of air (17) out of the fluid circuit (10) as fluid enters into the circuit (10). If a valve is closed, air (17) cannot be displaced out of circuit, which creates a pneumatic barrier (18) that prevents fluid from advancing within the circuit (under normal operating pressures).

DEVICES AND METHODS FOR PROGRAMMABLE MICROSCALE MANIPULATION OF FLUIDS

The present invention is directed generally to devices and methods for controlling fluid flow in meso-scale fluidic components in a programmable manner. Specifically, the present invention is directed to an apparatus and method for placing two microfluidic components in fluid communication at an arbitrary position and time, both of which are externally defined. The inventive apparatus uses electromagnetic radiation to perforate a material layer having selected adsorptive properties. The perforation of the material layer allows the fluid communication between microfluidic components. Other aspects of this invention include an apparatus and method to perform volumetric quantitation of fluids, an apparatus to program arbitrary connections between a set of input capillaries and a set of output capillaries, and a method to transport fluid in centripetal device from a larger to a smaller radius. In addition, the present invention also is directed to a method to determine the radial and polar ...

EMBEDDED CONTROL VALVE USING HOMOPOLAR MOTOR

A method for controlling fluid flow. A fluid (560) can be communicated to a first fluid flow port (105) disposed adjacent to a first surface (196) of a rotatable disk (115) of a homopolar motor. The fluid can flow through at least one orifice (130) in the rotatable disk to a second fluid flow port (110). The rotation of the disk can be selectively controlled to vary a fluid flow rate. Further, the disk can be rotated to align a selected one of the orifices with at least one of the first and second fluid flow ports. In another arrangement, the shape of the orifice can have a radial width that increases in a circumferential direction.

VALVE AND MICROPUMP INCORPORATING SAID VALVE

... 2065735 9201160 PCTABS00010 A valve is formed by machining a silicon wafer (18) bonded to a glass wafer (2). This machining forms a membrane (44) and a sealing ring. Part of the surface of the membrane (44) and optionally the sealing ring are oxidised in order to impart a mechanical pre-tension to the membrane holding the valve in a closed position. Further etching (52) may be carried out in a manner such that in the absence of the aforesaid pre-tension the valve is in the open position at rest.

THERMAL ARCHED BEAM MICROELECTROMECHANICAL STRUCTURE

A MEMS actuator is provided that produces significant forces and displacemen ts while consumming a reasonable amount of power. The MEMS actuator includes a microelectronic substrate, spaced apart support s on the substrate and a metallic arched beam extending between the spaced apart supports. The MEMS actuator also includes a heater for heating the arched beam to cause futher arching of the beam. In order to effectively transfer heat from the heater to the metallic arched beam, the metallic arched beam extends over and is spaced, albeit slightly, from the heater. As such, the MEMS actuator effectively converts the heat generated by the heater into mechanical motion of the metallic arched beam. A family of other MEMS devices, such as relays, switching arrays and valves, are also provided that include one or more MEMS actuators in order to take advantage of its efficient operating characteristics. In addition, a method of fabricating a MEMS actuator is further provided.

Valve fitted with a contact position detector and micropump comprising such a valve

The valve (26) is made in a silicon wafer (20). A position detector comprising a first electrical contact (54) formed on a glass support (32) bonded to the rear face of the wafer (20), a second electrical contact fixed to the wafer (20) and a circuit for measuring the electrical impedance (resistance or capacitance, depending on the embodiment) between the two electrical contacts is provided in order to detect by mechanical contact the position of the valve and thus detect an operating defect. Application to micropumps intended for injection of medicinal products. ...

Silicon wafer valve with position detector for micropump

A part(26) of a silicon wafer(20), etched to form an annular sealing ring(44) and suitable chambers, acts as an exit (regulating) valve of a micropump e.g. supplying medicinal injection fluid. In the closed position the sealing ring presses against a lower glass wafer surface(2). When the valve has fully opened by enforced change of shape, contact occurs between an electrode (68), on the upper side (56) of the valve wafer and grounded externally through a conductor (70), and an electrode (54) on the lower side of an upper glass wafer(32) supplied from a voltage source through a resistor. Contact- is detected by collapse of the voltage between the electrodes. AN alternative detection system uses the capacitance between the valve wafer and the electrode on the upper glass wafer.

Valve fitted in micro-pump

The value (32, 42) has a first wafer (18) in which a deformable membrane (34, 44) is made, and a second wafer (2) bonded to the first. A sealing ring (38, 46) on the face of one wafer has a free surface to contact the face of the other wafer (valve closed) or to be spaced apart from the other (valve open), according to the position of the membrane. The membrane has at least one layer of other material (40, 40a, 40b) inducing a mechanical strain keeping the value in the closed position in the asbence of external influence. At least one of the wafers is machined so that if the layer or layers would be omitted the value would be in the open position in absence of external influence.

Integrated valve and micropump comprising such a valve

The valve is formed by machining a silicon wafer (18) bonded to a small glass plate (2). This machining (chemical etching) defines a diaphragm (44) and a rib (46) forming a closure member. A part of the surface of the diaphragm (44) and optionally the rib (46) is oxidized in order to induce a mechanical prestress in the diaphragm which holds the valve in the closed position. Overetching (52) is carried out beforehand so that, in the absence of this prestress, the valve is in the open position when at rest. ...

MAGNETIC MICRO-VALVE USING A METAL BALL FOR CONVENIENT AND QUICK CONTROL AND A MANUFACTURING METHOD THEREOF

PURPOSE: A magnetic micro-valve using a metal ball and a manufacturing method thereof are provided to ensure convenient and quick control of a micro-valve by employing a permanent magnet or an electromagnet. CONSTITUTION: A magnetic micro-valve comprises an upper plate(10), a lower plate(20), a PDMS/metal ball combination, and a magnet. The upper plate comprises a micro-channel through which a fluid is delivered, a fluid inlet, and a fluid outlet. The lower plate is formed with a trench in part. The PDMS/metal ball combination includes a metal ball located in the center and PDMS surrounding the metal ball. The magnet is located on the micro-channel and generates a magnetic force. COPYRIGHT KIPO 2011 ...

DUAL DIAPHRAGM VALVE

A valve for regulating the flow of fluids (gas or liquid) using two flexible diaphragms in which an additional element is added to promote rolling contact between the diaphragms. The valve operates in a normally open configuration where fluid flows into the valve, passed through holes or openings in two electro-statically operative diaphragms and out of the valve. The holes or openings in one diaphragm are offset from the holes or openings in the other diaphragm, so that upon electro-static actuation, the diaphragms will seal together, closing the valve.

MEMS DEVICE FOR DELIVERY OF THERAPEUTIC AGENTS

An implantable device (200) for delivering a therapeutic agent to a patient is provided. The device includes a reservoir (390) configured to contain a liquid comprising the therapeutic agent. The device further includes a cannula (110) in fluid communication with the reservoir. The cannula has an outlet configured to be in fluid communication with the patient. The device further includes a first electrode and a second electrode, at least one of the first electrode and the second electrode is planar. The device further includes a material in electrical communication with the first and second electrodes. A voltage applied between the first electrode and the second electrode produces gas from the material, the gas forcing the liquid to flow from the reservoir to the outlet.

A VALVE EQUIPPED WITH A POSITION DETECTOR AND A MICROPUMP INCORPORATING SAID VALVE

A valve is formed from a silicon wafer (20). A position detector having a first electrical contact (54) formed on a glass support (32) mounted on the back face of the wafer (20), a second electrical contact fixed to the wafer (20) and a electrical impedance measurement circuit (resistance or capacitance according to the embodiment) between the two electrical contacts is provided to detect by contact the position of the valve and hence reveal any malfunction. Useful in micropump for the injection of medicaments.

Electrical appliance with automatic valve especially for fluid depolarized electrochemical battery

The placement in an electrical appliance of one or more tiny electrically activated thermally responsive semiconductor microactuators (a "valve-on-a-chip") disposed over the fluid entrance inlet(s) to regulate fluid flow to a gas depolarized electrochemical battery creates an efficient gas depolarized electrochemical power supply and appliance which permits the entrance of oxygen from air to the battery only when the battery is supplying electrical power to a load. Power for the valve is preferably derived from the battery itself but could be provided by a separate source within or without the battery. This tiny valve acts as a safety pressure vent and can act as a safety fuse as well. When electrical power is not required from the battery, the valve excludes entry of harmful impurities and unneeded fluid reactants thereby increasing the life of the battery during storage or when the electrical appliance the battery is powering is idle. A resistance means in parallel to the actuator valve ...

Valve unit and reaction apparatus having the same

Provided are a valve unit and a reaction apparatus having the valve unit. The valve unit includes a phase transition material, which melts and expands upon an application of the electromagnetic waves to the valve filler, and the valve filler is directed into the channel through the connection passage and closes the channel. The valve unit also includes heat generation particles, which are dispersed in the phase transition material and generate heat upon an application of electromagnetic wave energy.

CONTAINERS FOR LIQUID STORAGE AND DELIVERY WITH APPLICATION TO MICROFLUIDIC DEVICES

Valve device

A passive microvalve comprises a substrate (1) having a first aperture (2). An upper plate (7a) is mounted on the substrate and has a second aperture (7b) opening into a space defined between the substrate and the upper plate. A closure member (4) is mounted in the space and is movable between a first position in which it allows fluid flow between the first and second apertures and a second position in which it closes the second aperture.

MICROMACHINED FLUID FLOW REGULATORS

The fluid flow regulators are capable of accurately handling substantially continuous fluid flow rates as low as about 0.01 cc/day. The regulators are so miniaturized, corrosion-resistant and non-toxic that they are suitable for being implanted in the human body; and are capable of being mass produced at costs so low, by using micromachining techniques, such as etching, that they may be considered to be disposable. The regulators are passive devices which consume no electrical energy at all. The regulators are reliable because they may have as few as only two parts, only one which is a moving part; and because they may handle fluids at very low pressures.

POLYMER VALVES

Mikroventil

The microvalve of the invention is made up in layers of at least one lower part (11), a central part (12) and an upper part (13). The sealing ring (31) (closing member), the valve plate (29) (pressure equalisation area) and the diaphragm (26) are integrated into the central part (12), this one-piece component being produced by a plastic moulding process. The valve is actuated by anelectric operating device, e.g. an electrostatic, electromagnetic or piezoelectric drive. Especially in the case of an electrostatic drive, two electrodes (17, 22) are applied in layers to the central part (12) or the lower part (11). The lower, central and upper parts are put together and permanently bonded, e.g. adhesively or by welding.

Micro-valve has housing with two facing layers between which is valve chamber containing valve member, actuator, detector and condenser

The micro-valve (1) has a housing (2) produced by micro-structuring and comprising two facing layers (3,14;3,17) between which is a valve chamber (7) containing a membrane or plate-type valve member (5). At least one fluid duct (12) running in at least one of the two housing layers faces the valve member and opens into the valve chamber via a duct aperture (15). An electrically operated actuator (18) gives the relative position of the valve member in relation to the duct aperture. A detector (25) registers the position of the valve member on the basic of the capacity of an electric condenser (26) measured. The condenser has two facing condenser surfaces (27,27') formed by the electrode surfaces (22,22') of the electrostatic actuator, on the valve member and on one of the housing layers.

Lab-on-CD systems with magnetically actuated micro check valves and/or magnetic immobilization

The present invention provides lab-on-CD (LoCD) systems for conducting chemical and biological reactions. One of the LoCD systems comprises a microfluidic CD with at least one magnetically actuated micro check valve, said microfluidic CD having at least one sample reservoir, at least one reaction chamber, and at least one microfluidic channel connecting the at least one sample reservoir and the at least one reaction chamber; wherein the at least one magnetically actuated micro check valve is positioned to control the microfluidic flow in the at least one microfluidic channel; and a supporting CD with at least one magnetic element for providing a magnetic force; thereby when the microfluidic CD and the supporting CD are assembled into the LoCD system, the at least one magnetic element can move the at least magnetically actuated micro check valve so as to control the microfluidic flow in the at least one microfluidic channel.

MICRO ACTUATOR, PROCEDURE FOR MOVING A FLUID AND A PROCEDURE FOR MANUFACTURING A MICRO ACTUATOR

ACTUATORS FOR AN ARTIFICIAL JET FOR COOLING WARMED UP BODIES AND ENVIRONMENTS

DEVICES AND PROCEDURES FOR THE PROGRAMMABLE MICRO HANDLING OF FLUIDS

PASSIVE MICRO VALVE

MICRO VALVE

MICROMECHANICAL DEVICES WITH THERMAL SHEET CROSS BEAM AND ASSOCIATED MANUFACTURING PROCESSES

DUCTILE DRIVE COMPONENT WITH INCREASED RESETTING FORCE

Processing polynucleotide-containing samples

Methods and systems for processing polynucleotides (e.g., DNA) are disclosed. A processing region includes one or more surfaces (e.g., particle surfaces) modified with ligands that regain polynucleotides under a first set of conditions (e.g., temperature and pH) and release the polynucleotides under a second set of conditions (e.g., higher temperature and/or more basic pH). The processing region can be used to, for example, concentrate polynucleotides of a sample and/or separate inhibitors of amplification reactions from the polynucleotides. Microfluidic devices with a processing region are disclosed.

Remote valving for microfluidic flow control

MACROMECHANICAL COMPONENTS

SILICON DIAPHRAGM METERING OR FUEL INJECTOR VALVE

Integrated electrically operable micro-valve

Microfluidic membrane pump and valve

Method and apparatus for sorting particles

MICROVALVE DEVICE SUITABLE FOR CONTROLLING A VARIABLE DISPLACEMENT COMPRESSOR

A device is disclosed for controlling a variable displacement compressor. The device comprises a microvalve operated control valve. A microvalve device for controlling fluid flow and a micro spool valve for use as a microvalve are also disclosed.

VALVE ASSEMBLY FOR MICROFLUIDIC DEVICES, AND METHOD FOR OPENING AND CLOSING SAME

A normally open fluid manipulation valve assembly (20) and system, and a method for closing, re-opening and re-closing same. The normally open valve assembly can include a substrate (22) including a first surface, with first and second recesses (28, 30) formed in the first surface. A recessed channel (34) can be formed in the first surface. The recessed channel can extend from the first recess to the second recess and can be at least partially defined by a first deformable material (42) having a first modulus of elasticity. The valve assembly can also include an elastically deformable material (32) having a modulus of elasticity that is greater than the modulus of elasticity of the first deformable material, and an adhesive layer (44) that contacts the first surface.

EMBEDDED CONTROL VALVE USING ELECTROACTIVE MATERIAL

A microfluidic control valve (100) comprising a dielectric structure (105) defining at least one cavity (260) therein. An electroactive material (305), such as an electroactive polymer, is disposed in a portion of the cavity. The electroactive material is operable between a first state in which a dimension of the electroactive material has a first value and a second state in which the dimension has a second value. Two conductors (240, 250) can be included for applying a voltage potential across the electroactive material to change the electroactive material between the first state and the second state. A first fluidic port (310) can be located proximate to the electroactive material such that a fluid flows through the first fluidic port when the electroactive material is in the first state, and the electroactive material at least partially blocks the first fluidic port when the electroactive material is in the second state.

PHOTOCURABLE PERFLUOROPOLYETHERS FOR USE AS NOVEL MATERIALS IN MICROFLUIDIC DEVICES

... ²²²A functionalized photocurable perfluoropolyether is used as a material for ²fabricating a solvent-resitant microfluidic device. Such solvent~ resistant ²microfluidic devices can be used to control the flow of small amounts of a ²fluid, such as an organic solvent, and to perform microscale chemical ²reactions that are not amenable to other polymer-based microfluidic devices.² ...

EMBEDDED CONTROL VALVE USING ELECTROACTIVE MATERIAL

EMBEDDED CONTROL VALVE USING HOMOPOLAR MOTOR

ELECTROFORMED MULTILAYER FLOW REGULATOR INCORPORATING FORCE-GENERATING MEANS FOR SELECTIVELY CONSTRICTING THE FLUID FLOW PATH, AND A PROCESS FOR THE PREARATION THEREOF

A zero sack volume fluid flow regulator generates upstream turbulence for control of fluid flow, fluid spray distribution and fluid droplet size. The fluid flow regulator includes a seal layer (5) for selectively controlling fluid flow. The seal layer (5) is resiliently movable relative to a base layer (3) to selectively constrict a turbulence inducing intermediate channel (10) within the regulator and selectively control fluid flow. A method of fabricating the fluid flow regulator utilizes a multilayer resist process in conjunction with a multilayer electroforming process.

THERMAL MICROVALVES

Thermal microvalves and their method of use include a fusible material (40) positioned in a microchannel (44). A heater (42) melts the material (40) which is then forced by air pressure (46) into a second channel (48) where it cools and solidifies, blocking flow. Alternatively, the melted and solidified material (40) can hold a diaphragm of a diaphragm valve in place, eliminating the need for continued applied force on the diaphragm.

A method of manufacturing a microsystem, such a microsystem, a stack of foils comprising such a microsystem, an electronic device comprising such a microsystem and use of the electronic device

The invention relates to a method of manufacturing a microsystem and further to such microsystem. With the method a microsystem can be manufactured by stacking pre-processed foils (10) having a conductive layer (11a,11b) on at least one side. After stacking, the foils (10) are sealed, using pressure and heat. Finally the microsystems are separated from the stack (S). The pre-processing of the foils (preferably done by means of a laser beam) comprises a selection of the following steps: (A) leaving the foil intact, (B) locally removing the conductive layer, (C) removing the conductive layer and partially evaporating the foil (10), and (D) removing both the conductive layer as well as foil (10), thus making holes in the foil (10). In combination with said stacking, it is possible to create cavities, freely suspended cantilevers and membranes. This opens up the possibility of manufacturing various microsystems, like MEMS devices and microfluidic systems.

Integrated micro-type pressure-resist flow control module

An integrated micro-type pressure-resist flow control module is provided. Fluid flows into the integrated module and through a pressure-resist sensor channel and a suspended microstructure to enter a thermo-driven microvalve area. The microvalve area drives a silicon microbridge with mesa utilizing thermo-actuation to open the microvalve of linear proportional flow. There is provided a pressure-resist microflow sensor unit in front of the flow channel for sensing flow. The sensor unit contains a microcantilever structure made with pressure-resist material, which is perpendicular to the flow entrance of the module so that momentum of the flow is perpendicular to the ancon, to obtain a sensed flow value with the inclined ancon changing resistance value. The sensor unit is constructed with the microvalve and the silicon microbridge utilizing an integrated manufacturing process to decrease steps of manufacturing process and reduce the volume of the module.

CONTAINERS FOR LIQUID STORAGE AND DELIVERY WITH APPLICATION TO MICROFLUIDIC DEVICES

A container (1 ) for a liquid reagent (9), wherein the container has an outer wall (3) and an internal piercing member (6), such that, upon application of pressure to the outer wall of the container, the internal piercing member punctures the container from the inside, thereby liberating the liquid contained therein Such a container is configured to store the liquid for periods between 6 to 18 months with minimal loss of the liquid inside, other than if the container is ruptured Such a container is also configured to require a particular force to be applied to the outer wall to cause the internal piercing member to puncture the container, such a force being greater than that ordinarily experienced by the container during routine storage, transport, or handling The container is preferably adapted for use with a microfluidic cartridge.

ELECTROFLUIDIC STANDARD MODULE AND CUSTOM CIRCUIT BOARD ASSEMBLY

A miniature electrofluidic module (10, 310) is disclosed, for receiving one or more fluids and for receiving an electrical connection. In accordance with one aspect of the invention, the module (10, 310) includes a substantially flat fluidic manifold layer (64, 364) for fluid distribution, a substantially flat electrical layer (80, 380) including an electrical circuit (16, 316) and a substantially flat device layer (13) including micromachined devices (14). The devices (14) may include electrically actuated valves (14) for modulating the flow of fluids. In another aspect of the invention, an electrofluidic module (10, 310) is combined with an electrofluidic circuit board (196, 250). In a further aspect, an electrofluidic system such as a dialysate handling system is disclosed, including a fluidic fixture (196) and an electrofluidic assembly (198) incorporating electrofluidic devices (14). In a still further aspect of the invention, a method is disclosed for interfacing micromachined devices ...

MICROVALVE

A microvalve for regulating a fluid flow has a valve base body (10) with a valve opening (12; 40) and a sealing edge, and a valve plate (14) with fluid passages (16; 60). The valve plate (14) is movable in the perpendicular direction in relation to the valve base body (10), so that in a first position the valve plate (14) closes the valve opening (12; 40) and in a second position it is vertically spaced away from the valve opening (12; 40), defining a cross-section of flow through the valve opening (12; 40) and the valve plate (14) determined by the distance between the sealing edge and the valve plate (14). The contour of the sealing edge (42) of the valve opening (12; 40) is selected in such a way that the sealing edge (42) is longer than the sealing edge (39) of a square-shaped valve opening of the same surface area.

Thermal microvalves in a fluid flow method

The movement and mixing of microdroplets through microchannels is described employing silicon-based microscale devices, including microdroplet transport channels, reaction regions, electrophoresis modules, and radiation detectors. The discrete droplets are differentially heated and propelled through etched channels. Electronic components are fabricated on the same substrate material, allowing sensors and controlling circuitry to be incorporated in the same device.

Closing blade for deformable valve in a microfluidic device and method

A microfluidic manipulation system is provided that includes a blade for manipulating deformable material and at least one movable support that is capable of moving the blade into contact with a microfluidic device including a deformable feature. When the microfluidic device is operatively held by a holder, a movable support can position the distal end of the blade relative to the microfluidic device and move the contact tip surface of the blade such that it deforms the deformable feature.

Devices Employing Colloidal-Sized Particles

The present invention relates to the use colloidal particles to realize photonic and microfluidic devices. In particular embodiments, colloidal particles are used to realize microfluidic a two-way valve, three-way valve, check valve, three-dimensional valve, peristalsis pump, rotary pump, vane pump, and two-lobe gear pump. In certain embodiments, actuation of an active element in the microfluidic structure is accomplished by electrophoresis, the use of an optical trap or “tweezer”, or the application of an electric field or magnetic field. In other embodiments, the application of an electrical field to colloidal particles that are substantially constrained to two dimensional movement is used to realize wave guides, filters and switches for optical signals.

Microvalve device suitable for controlling a variable displacement compressor

A device is disclosed for controlling a variable displacement compressor. The device comprises a microvalve operated control valve. A microvalve device for controlling fluid flow and a micro spool valve for use as a microvalve are also disclosed.

Flow rate monitoring device

MICROMEMBRANE PUMP

MIKROMASCHINEN-FLÜSSIGKEITSFLUSS-REGULATOR

VALVE ELEMENT FOR USE IN AN INK-JET PRINTER HEAD

MIKROVENTIL.

The valve has a narrow bore (20) through a glass substrate (14) and is operated by a membrane (7) held onto a silicon substrate (2) on sprung supports (8). An opposing electrode (21) is applied to the glass substrate around the valve aperture. The valve is operated by electrostatic force between the electrode and the membrane. The remainder of the valve is provided by a shaped aperture (9) etched or drilled through the silicon. The silicon and glass substrates are joined by anodic bonding.

Microminiature fluid flow device

MICRO-FLUID DEVICES AND PROCEDURES FOR CHEMICAL SAMPLE

BY MICRO PRODUCTION MANUFACTURE OF FLUIDIC CIRCUIT ELEMENTS AND - APPLICATIONS

DIAPHRAGM PUMP WITH FLEXIBLE PUMP DIAPHRAGM

MICROMECHANICAL ACTUATOR.

MINIATURIZED VALVE MECHANISM

IN A MICRO VALVE FOR PRESSURE CONTROL AND IN A PROPORTIONAL MICRO VALVE APPLICABLE ONE MICROMECHANICAL STRUCTURE

Thermal microvalves

Electroformed multilayer flow regulator

PARYLENE MICRO CHECK VALVE AND FABRICATION METHOD THEREOF

The present disclosure describes a Parylene micro check valve (10) including a micromachined silicon valve seat (15) with a roughened top surface to which a membrane cap (20) is anchored by twist-up tethers (25). The micro check valve is found to exhibit low cracking pressure, high reverse pressure, low reverse flow leakage, and negligible membrane-induced flow resistance when used as a valve over a micro orifice through which flow liquid and gas fluids.

FUNCTIONAL MATERIALS AND NOVEL METHODS FOR THE FABRICATION OF MICROFLUIDIC DEVICES

The presently disclosed subject matter provides functional perfluoropolyether (PFPE) materials for use in fabricating and utilizing microscale devices, such as a microfluidic device. The functional PFPE materials can be used to adhere layers of PFPE materials to one another or to other substrates to form a microscale device. Further, the presently disclosed subject matter provides a method for functionalizing the interior surface of a microfluidic channel and/or a microtiter well. Also the presently disclosed subject matter provides a method for fabricating a microscale structure through the use of a sacrificial layer of a degradable material.

FLUIDIC CONTROL SYSTEM AND METHOD OF MANUFACTURE

A fluidic control system includes featured layers. The featured layers in clude two or more features which collectively form at least one functional c omponent.

MICROFLUIDIC DEVICES AND METHODS FOR CHEMICAL ASSAYS

An assay device in which to carry out a fluid-phase chemical assay, comprising means for supporting a test substrate, a sample chamber for receiving a fluid sample and at least one fluid control device for controlling the movement of fluid into and/or out of the sample chamber, wherein the fluid control device comprises a fluid outlet chamber in fluid communication with the sample chamber, and a displaceable flexible diaphragm the displacement of which alters the volume of the outlet chamber so as to allow and/or restrict fluid flow between the outlet and sample chambers. The invention also provides assay apparatus incorporating such a device, an assay station for use as part of such apparatus, a fluid control unit for use as part of the assay device and a method of conducting an assay which may involve the use of such apparatus and devices.

ELECTRICAL MICROVALVE AND METHOD OF MANUFACTURING THEREOF

The present invention relates to a microvalve for controlling a fluid flow in a microchannel, to a microfluidic circuit using the microvalve, and to a manufacturing method thereof. The microvalve has a first electrode located on a portion of the microchannel, a second electrode over the microchannel and substantially aligned with the first electrode forming a membrane with substantially no resilience. In function, upon application of an electric force on the first and second electrodes, the second electrode draws nearer the first electrode, thus obstructing the microchannel. The microfluidic circuit comprises multiple microchannels and at least one microvalve affixed to one of the multiple microchannels, wherein the at least one microvalve is adapted to indirectly actuate a flexible valve adapted to regulate a flow of fluid in another one of a multiplicity of microchannels.

SMALL VALVE

A small valve using a shape memory alloy, wherein a movable valve element (3) having a sealing part (5) internally coming into contact with a guide pipe (1) to close an orifice (2), a bias coil (8) installed between the orifice (2) and the movable valve element (3), and a wire (9) formed of the shape memory alloy held between the fixed electrode (11) of the guide pipe (1) and the movable electrode (12) of the movable valve element (3) are installed in the guide pipe (1) with the built-in orifice (2). The wire (9) is heated to deform the shape memory alloy so as to move the movable valve element (3) in order to close the orifice (2). A coiled spring (7) for stress reduction is disposed in the movable valve element (3) to elastically deform the movable valve element so that an overload on the movable valve element (3) due to the excessive contraction of the wire (9) can be absorbed by the elastic deformation of the movable valve element (3) itself. Since the likelihood of reoccurrence of ...

METHOD FOR PRODUCING AND TESTING A CORROSION-RESISTANT CHANNEL IN A SILICON DEVICE

A method for producing a corrosion-resistant channel in a wetted path of a silicon device enables such device to be used with corrosive compounds, such as fluorine. A wetted path of a MEMS device is coated (210) with either an organic compound resistant to attack by atomic fluorine or a material capable of being passivated by atomic fluorine. The device is then exposed to a gas that decomposes into active fluorine compounds (220) when activated by a plasma discharge. One example of such a gas is CF4, an inert gas that is easier and safer to work with than volatile gases like CIF3. The gas will passivate the material (if applicable) and corrode any exposed silicon. The device is tested (230) in such a manner that any unacceptable corrosion of the wetted path will cause the device to fail. If the device operates properly, the wetted path is deemed to be resistant to corrosion by fluorine or other corrosive compounds, as applicable.

MICROFLUIDIC DEVICES AND METHODS FOR CHEMICAL ASSAYS

An assay device in which to carry out a fluid-phase chemical assay, comprising means for supporting a test substrate, a sample chamber for receiving a fluid sample and at least one fluid control device for controlling the movement of fluid into and/or out of the sample chamber, wherein the fluid control device comprises a fluid outlet chamber in fluid communication with the sample chamber, and a displaceable flexible diaphragm the displacement of which alters the volume of the outlet chamber so as to allow and/or restrict fluid flow between the outlet and sample chambers. The invention also provides assay apparatus incorporating such a device, an assay station for use as part of such apparatus, a fluid control unit for use as part of the assay device and a method of conducting an assay which may involve the use of such apparatus and devices.

Relief valve, method of manufacturing relief valve, and fuel cell

Provided is a relief valve that is small in size and has a simple structure in which a flow path is provided so as to penetrate a diaphragm or a support portion of the diaphragm, and an outlet is located at an opposite side of an inlet through the diaphragm. The relief valve for pressure adjustment is made of a semiconductor wafer and operates in a case where a pressure at a fluid inlet is higher than a pressure at a fluid outlet by a pressure higher than a set pressure value, the relief valve including a flow path communicating the fluid inlet with the fluid outlet and a diaphragm for opening and closing the flow path by deformation utilizing a differential pressure between the fluid inlet and the fluid outlet, wherein the flow path penetrates the diaphragm or is disposed at a side surface of the diaphragm, the diaphragm and the valve seat are in contact with each other, and the flow path is opened and closed by deformation of the diaphragm.

Micromachined fluid handling apparatus with filter

The fluid handling devices are capable of accurately handling substantially continuous fluid flow rates as low as about 0.01 cc/day. The devices are so miniaturized, corrosion-resistant and non-toxic that they are suitable for being implanted in the human body; and are capable of being mass produced at costs so low, by using micromachining techniques, such as etching, that they may be considered to be disposable. The devices are either passive devices which consume no electrical energy at all, or are active devices which consume very small amounts of electrical energy. The devices are reliable because they may have as few as only two parts, only one which is a moving part; and because they may handle fluids at very low pressures. The fluid handling devices include active piezoelectrically driven membrane pumps; and passive fluid flow regulators, on-off valves, flow switches and filters.

Microreactor and method of liquid feeding making use of the same

A microreactor capable of reaction between a sample and a mixed reagent containing a mixture of multiple reagents, which microreactor avoids the interposition of air between driving solution and reagents and realizes high-precision controlling of the timing of mixing of reagents and other liquids, the mixing ratio of liquids, the pressure for liquid feeding, etc. Further, there is provided a method of liquid feeding making use of the same. Accordingly, a flow path branched at the position of an inlet from a flow path through which an opening communicating with an external pump communicates with the inlet is provided with an air evacuation flow path with its terminal open outward. Further, the flow path resistance of the air evacuation flow path for a liquid is made greater than the flow path resistance, for the liquid, of a flow channel from the reagent storage chamber to a reagent feed-out flow path.

Mobile monolithic polymer elements for flow control in microfluidic devices

A cast-in-place and lithographically shaped mobile, monolithic polymer element for fluid flow control in microfluidic devices and method of manufacture. Microfluid flow control devices, or microvalves that provide for control of fluid or ionic current flow can be made incorporating a cast-in-place, mobile monolithic polymer element, disposed within a microchannel, and driven by either fluid or gas pressure against a retaining or sealing surface. The polymer elements are made by the application of lithographic methods to monomer mixtures formulated in such a way that the polymer will not bond to microchannel walls. The polymer elements can seal against pressures greater than 5000 psi, and have a response time on the order of milliseconds. By the use of energetic radiation it is possible to depolymerize selected regions of the polymer element to form shapes that cannot be produced by conventional lithographic patterning and would be impossible to machine.

MICROVALVE DEVICE SUITABLE FOR CONTROLLING A VARIABLE DISPLACEMENT COMPRESSOR

SWITCHABLE SURFACES

A substrate having a surface with reversibly switchable properties. The surface comprises a nanolayer of a material that switches from a first conformation stateto a second conformation state when an external stimulus is applied. When the nanolayer is in the first conformation state, the surface is characterized by a first property, and when the nanolayer is in the second conformation state, the surface is characterized by a second property.

valve assenbly for a microfluidic system

Die Erfindung betrifft eine Ventilvorrichtung für ein Mikrofluidsystem, das ein erstes und ein zweites Fluidreservoir, eine Flusskammer, eine Fluidkanalanordnung und eine Fördereinrichtung umfasst, wobei das erste Fluidreservoir über die Flusskammer mit dem zweiten Fluidreservoir durch die Fluidkanalanordnung fluidisch verbunden ist, wobei die Ventilvorrichtung aus einem ersten Zustand in einen zweiten Zustand bringbar ist, so dass im ersten Zustand ein Fluid mittels der Fördereinrichtung vom ersten Fluidreservoir durch die Flusskammer mit einer vorherbestimmten Strömungsrichtung in das zweite Fluidreservoir förderbar ist und im zweiten Zustand ein Fluid mittels der Fördereinrichtung vom zweiten Fluidreservoir durch die Flusskammer mit der vorherbestimmten Strömungsrichtung in das erste Fluidreservoir förderbar ist.

Microfluidic system including a bubble valve for regulating fluid flow through a microchannel

A microfluidic system includes a bubble valve for regulating fluid flow through a microchannel. The bubble valve includes a fluid meniscus interfacing the microchannel interior and an actuator for deflecting the membrane into the microchannel interior to regulate fluid flow. The actuator generates a gas bubble in a liquid in the microchannel when a sufficient pressure is generated on the membrane.

Thermal Microvalves

The movement and mixing of microdroplets through microchannels is described employing silicon-based microscale devices, comprising microdroplet transport channels, reaction regions, electrophoresis modules, and radiation detectors. The discrete droplets are differentially heated and propelled through etched channels. Electronic components are fabricated on the same substrate material, allowing sensors and controlling circuitry to be incorporated in the same device.

Micro-Fluidic System

A micro-fluidic system comprising a micro-fluidic channel, which has a wall provided with a hole; a closing element, which is partially housed within the hole and has a membrane portion adapted to deform and a side portion sealingly connected with the above mentioned wall; and a partition arranged within the micro-fluidic channel between a first and a second segment; the closing element is deformable between a locked configuration in contact with the partition and an open configuration spaced from the partition; the closing element may be deformed by suction or by a rod or a piston.

MICROFLUIDIC OSCILLATOR PUMP

Microfluidic oscillator circuits and pumps for microfluidic devices are provided. The microfluidic pump may include a plurality of fluid valves and a microfluidic oscillator circuit having an oscillation frequency. The fluid valves may be configured to move fluids. Each fluid valve may be connected to a node of the microfluidic oscillator circuit. The pumps may be driven by the oscillator circuits such that fluid movement is accomplished entirely by circuits on a microfluidic chip, without the need for off-chip controls. 1. A microfluidic pump , located on a microfluidic device , the microfluidic pump comprising:a microfluidic oscillator circuit having an oscillation frequency; anda plurality of fluid valves configured to move fluids, each fluid valve connected to a node of the microfluidic oscillator circuit.2. The microfluidic pump of claim 1 , wherein the microfluidic oscillator circuit includes:an odd number of inverter logic gates implemented by pneumatic or hydraulic valves, the logic gates being connected in a closed loop, anda plurality of nodes, each node being located between two inverter logic gates.3. The microfluidic pump of claim 2 , wherein the oscillation frequency varies as a function of the number of inverter logic gates in the oscillator circuit.4. The microfluidic pump of claim 2 , wherein the microfluidic oscillator circuit has a volume comprising the volume of the pneumatic or hydraulic valves and the volume of the channels connecting the pneumatic or hydraulic valves claim 2 , wherein the oscillation frequency varies as a function of the volume of the microfluidic oscillator circuit.5. The microfluidic pump of claim 2 , wherein each inverter logic gate includes a pull-up resistor having a pull-up resistance claim 2 , and wherein the oscillation frequency of the circuit varies as a function of the pull-up resistance of the inverter logic gates of the circuit.6. The microfluidic pump of claim 1 , wherein the microfluidic oscillator circuit is ...

FLUID HANDLING DEVICE AND FLUID HANDLING SYSTEM

This fluid handling device has a rotary member that is rotatable around the central axis. In the rotary member, a first protruding part for pressing and closing a valve of a flow channel chip and a recessed part for opening the valve without pressing the valve are disposed on the circumference of a first circle around the central axis. The rotary member further has a second protruding part for, when the recessed part is located at the valve in a state where the rotary member is rotated, pressing the valve so as not to open the valve. 1. A fluid handling device configured to control fluid in a channel of a channel chip , a plurality of introduction channels;', 'a common channel connected to the plurality of introduction channels; and', 'a plurality of valves disposed for the plurality of introduction channels, each of the plurality of valves being disposed in each of the plurality of introduction channels or at a connecting portion between each of the introduction channel and the common channel; and, 'wherein the channel chip includes a first protrusion configured to close the plurality of valves by pressing a diaphragm of each of the plurality of valves;', 'a recess configured to open the plurality of valves without pressing the diaphragm of each of the plurality of valves, the first protrusion and the recess being disposed on a circumference of a first circle around the central axis; and', 'a second protrusion configured to close a valve of the plurality of valves that is opposite to the recess by pressing a diaphragm of the valve of the plurality of valves when the recess is located over the valve of the plurality of valves in a state where the rotary member is rotated., 'wherein the fluid handling device includes a rotary member rotatable around a central axis, the rotary member including2. The fluid handling device according to claim 1 , wherein the second protrusion is disposed on a circumference of a second circle disposed around the central axis claim 1 , the ...

SPRING-LESS MULTI-POSITION MICRO-FLUIDIC VALVE ASSEMBLY

A springless rotary shear that produces compression forces by utilizing the stiffness properties of polymer seals. The valve is designed to produce an effective spring load, with inherent sealing force, by deflecting polymer elements whose response depends on stiffness that is governed by each component's elastic modulus and geometry. A stator seal protrudes thousandths of an inch beyond a stator seal housing. When a stator is fastened down to the stator seal housing the clamping forces are transmitted to the stator seal, rotor seal, shaft adapter, bearings and housings, and the assembly is deflected to a flush position, resulting in a sealing force between the rotor and stator seal. The transmitted sealing force is as a function of the stiffness of each component and the protrusion distance of the stator seal above the mating surface prior to fastening the stator. 1. A spring-less micro-fluidic valve assembly comprising:a stator seal device defining a substantially planar stator face and an opposite, distal facing stator contact surface perimetrically defined by a contact surface perimeter, said stator seal device including at least two or more stator channels extending therethrough from said contact surface to corresponding stator ports at said stator face;a rotor seal device having a substantially planar rotor face defining one or more rotor channels and an opposite, proximally facing rotor contact surface;a relatively rigid actuator housing having an inner wall defining an axially extending receiving passage therethrough, said inner wall including distally facing housing bearing support surface;a shaft adapter configured for axial receipt in said receiving passage of the actuator housing, and defining a proximally facing adapter bearing support surface and a distally facing adapter contact surface configured for contact support of said rotor contact surface;a bearing assembly disposed between the housing bearing support surface and the adapter bearing support ...

Micro-valve

Provided is a micro-valve having a laminate structure capable of improving sealing performance when a foreign substance is mixed. The micro-valve 10 has a laminate structure and includes a base layer 20 and a diaphragm layer 30. The base layer is formed with an inlet port 23 for introducing a gas into the micro-valve and an outlet port for allowing the gas to flow outside. The diaphragm layer is arranged to face the base layer. The diaphragm layer switches the flowing and blocking of the gas from the inlet port to the outlet port by elastic deformation thereof. The diaphragm layer has a configuration in which a plurality of deformation regions 33 and a plurality of rigid body regions 34 are alternately formed, the deformation region being elastically deformable in accordance with an inflow of a pneumatic fluid into the micro-valve. The diaphragm layer closes at least one of the inlet port and the outlet port by elastic deformation of at least a part of the plurality of deformation regions.

Microfluidic pump and valve structures and fabrication methods

Plastic microfluidic structures having a substantially rigid diaphragm that actuates between a relaxed state wherein the diaphragm sits against the surface of a substrate and an actuated state wherein the diaphragm is moved away from the substrate. As will be seen from the following description, the microfluidic structures formed with this diaphragm provide easy to manufacture and robust systems, as well readily made components such as valves and pumps.

Laminated microfluidic structures and method for making

A method for making a polymeric microfluidic structure in which two or more components (layers) of the microfluidic structure are fixedly bonded or laminated with a weak solvent bonding agent, particularly acetonitrile or a mixture of acetonitrile and alcohol. In an aspect, acetonitrile can be used as a weak solvent bonding agent to enclose a microstructure fabricated in or on a non-elastomeric polymer such as polystyrene, polycarbonate, acrylic or other linear polymer to form a three-dimensional microfluidic network. The method involves the steps of wetting at least one of the opposing surfaces of the polymeric substrate components with the weak solvent bonding agent in a given, lower temperature range, adjacently contacting the opposing surfaces, and thermally activating the bonding agent at a higher temperature than the lower temperature range for a given period of time. The contacted polymeric substrates may also be aligned prior to thermal activation and compressed during thermal activation. A laminated, polymeric microfluidic structure is also disclosed.

Membrane-based fluid control in microfluidic devices

A microfluidic device may include a substrate that defines a flow-control cavity and first and second channels in fluid communication with the flow-control cavity. A compliant membrane for regulating fluid flow through the flow-control cavity may surround at least a portion of the flow-control cavity.

FLUID FLOW DEVICE AND METHOD OF OPERATING SAME

Provided is a fluid flow device including a flow passage structure including in the interior a micro-channel and an escape flow passage for allowing a fluid to escape from the micro-channel. The micro-channel includes a folded-back flow passage portion that allows the fluid to flow upward before allowing the same to flow downward. The folded-back flow passage portion includes a top portion disposed at the highest position of the folded-back flow passage portion and an upward flow passage portion and a downward flow passage portion with the top portion as a boundary therebetween that allow the fluid to flow upward and downward, respectively, and the escape flow passage is connected to the top portion of the folded-back flow passage portion. 1. A fluid flow device for performing predetermined processing while allowing a fluid to flow , comprising:a flow passage structure including in an interior at least one micro-channel for allowing a fluid that is a processing object and at least one escape flow passage for allowing the fluid to escape from the micro-channel; anda discharge switch part configured to be switchable between an allowance state in which the fluid is allowed to be discharged from the escape flow passage and a prevention state in which the fluid is prevented from being discharged from the escape flow passage,wherein the micro-channel includes at least one folded-back flow passage portion that allows the fluid to flow upward before allowing the same to flow downward,the folded-back flow passage portion includes a top portion disposed at a highest position of the folded-back flow passage portion, an upward flow passage portion connected to the top portion and allowing the fluid to flow upward and flow into the top portion, and a downward flow passage portion connected to the top portion and allowing the fluid flowing in from the top portion to flow downward, andthe escape flow passage is connected to the top portion or a portion adjacent thereto of the ...

MICROFLUIDIC DEVICE AND CONTROL EQUIPMENT FOR MICROFLUIDIC DEVICE

Provided is a microfluidic device to more easily and mechanically operate a valve for controlling a fluid flow, which comprises: a platform having a plurality of chambers; at least one flow channel which connects between the chambers; and a valve which opens or closes the flow channel, wherein the valve includes a blocking member which selectively blocks the flow channel and a pressing member installed in the blocking member to move the blocking member, and the pressing member has a structure which presses and moves the blocking member by the linear reciprocating motion in the same direction as the direction of an external force, and the valve further includes a driving unit which reversibly controls the opening and closing of the flow channel caused by the blocking member by fixing the pressing member to the position of the moved pressing member or returning to the original position. 1. A microfluidic device comprising:a platform having a plurality of chambers; at least one flow channel which connects between the chambers; and a valve which opens or closes the flow channel,wherein the valve includes a blocking member which selectively blocks the flow channel and a pressing member installed in the blocking member to move the blocking member, andthe pressing member has a structure which presses and moves the blocking member by the linear reciprocating motion in the same direction as the direction of an external force, andthe valve further includes a driving unit which reversibly controls the opening and closing of the flow channel caused by the blocking member by fixing the pressing member to the position of the moved pressing member or returning to the original position.2. (canceled)3. The microfluidic device of claim 1 ,wherein the driving unit has a structure which selectively positions the pressing member to any one of the first position for blocking the flow channel or the second position for opening the flow channel.4. The microfluidic device of claim 3 , ...

Microvalve device and fluid flow control method

A microvalve device and fluid flow control method, the microvalve device comprising: a microvalve body, the microvalve body being composed of multiple layers and comprising a first layer ( 1 ) and a second layer ( 2 ) bonded with the first layer ( 1 ), the second layer ( 2 ) having a plurality of fluid ports ( 7, 8, 9 ); a cavity ( 6 ) disposed between the first layer and the second layer; a plurality of actuators ( 3, 4, 5 ) respectively disposed corresponding to each fluid port, the plurality of actuators ( 3, 4, 5 ) controlling the opening and closing of the plurality of fluid ports ( 7, 8, 9 ). The fluid flow control method comprising: respectively employing a plurality of actuators to independently control the opening and closing of a plurality of fluid ports.

VALVED CARTRIDGE AND SYSTEM

This disclosure provides, among other things, a cartridge comprising: (a) a cartridge body comprising a malleable material and having, disposed on a surface of the body, at least one valve body comprising a valve inlet and a valve outlet, each fluidically connected to a fluidic channel; and (b) a layer comprising a deformable material bonded to a surface of the cartridge body and sealing the at least one valve body at points of attachment, thereby forming at least one valve; wherein the at least one valve body is depressed in the cartridge body relative to the points of attachment and wherein the deformable material covering the at least one valve body retains sufficient elasticity after deformation such that in a ground state the valve is open. Also disclosed is an instrument comprising a cartridge interface and a cartridge as described herein engaged with the cartridge interface, wherein (II) the cartridge interface comprises: (A) at least one mechanical actuator, each mechanical actuator positioned to actuate a valve; and (B) at least one motor operatively coupled to actuate a mechanical actuator toward or away from a valve. 148-. (canceled)49. A method of making an article comprising:(a) providing a cartridge body comprising a malleable material and having, disposed on a surface of the body, at least one valve body comprising a valve inlet and a valve outlet, each fluidically connected to a fluidic channel; and(b) providing a layer comprising a deformable material;(c) bonding the layer to the surface to seal the at least one valve body at points of attachment, thereby forming at least one valve, wherein the at least one valve body is depressed in the cartridge body relative to the points of attachment; and(d) deforming the deformable layer covering the at least one valve body wherein the deformable layer undergoes plastic deformation and retains sufficient elasticity such that in a ground state the valve is open.50. The method of claim 49 , wherein bonding ...

Reconfigurable microvalve optical waveguide

An optical waveguide comprises multiple layers of solid-state material disposed on a substrate. One of the layers is a lifting-gate valve made of a high refractive index material. The device provides for better optical confinement in microfluidic channels, and has the capability to integrate both optical signals and fluid sample processing. The optical paths on the chip are reconfigurable because of the use of a movable microvalve that guides light in one of its positions.

CARTRIDGE, ANALYSIS SYSTEM AND METHOD FOR TESTING A SAMPLE

A cartridge, an analysis system and a method for analyzing, in particular, a biological sample, wherein a first group having one or more valves and a second group having one or more valves can be or are actuated from different sides of the cartridge. 2. The analysis system according to claim 1 , wherein the cartridge is adapted to be arranged between at least two of the plurality of actuation apparatus.3. The analysis system according to claim 1 , wherein the cartridge is adapted to be at least partially received by the analysis device.4. The analysis system according to claim 1 , wherein the cartridge comprises an at least substantially planar or flat support.5. The analysis system according to claim 4 , wherein at least one of the channels and the valves are formed by depressions in the support.6. The analysis system according to claim 1 , wherein the plurality of valves comprises a first group having at least one valve and a second group having at least one valve claim 1 , the at least one valve of the first group being actuatable from a different side of the cartridge from the at least one valve of the second group.7. The analysis system according to claim 6 , wherein the valves of the first group can be opened irreversibly or closed irreversibly.8. An analysis system according to claim 1 , wherein the plurality of valves comprises a first group having at least two valves and a second group having at least two valves claim 1 , wherein the valves of the first group are opened by actuation and the valves of the second group are closed by actuation claim 1 , wherein one valve of the first group is arranged upstream and one valve of the first group is arranged downstream of the storage cavity claim 1 , so that the storage cavity is closed in a storage-stable manner by the two valves of the first group when said valves are unactuated claim 1 , and wherein a valve of the second group is arranged immediately next each of said upstream and downstream valves of the first ...

FLOW CONTROL MECHANISM AND SYSTEM COMPRISING THE MECHANISM

A flow control mechanism and a system comprising the mechanism, specifically relating to a microflow control mechanism and system. The mechanism comprises a base and a constant volume mechanism. The base and the constant volume mechanism are dynamically connected to form two or more relative activity states, comprising a first relative state and a second relative state. A fluid input end and a fluid receiving end are provided on the base. The constant volume mechanism is provided with a constant volume pipeline. In the first relative state, the fluid input end communicates with the constant volume pipeline. In the second relative state, the constant volume pipeline communicates with the fluid receiving end. The microflow control mechanism and system can achieve precise micro-scale fluid flow control, and have a simple structure. 1. A fluid control mechanism , wherein a base and a quantitative mechanism which are movably connected to form two or more relative motion states including a first relative state and a second relative state , wherein fluid input ends and fluid receiving ends are disposed on the base; the quantitative mechanism is provided with quantitative pipelines; when in the first relative state , the fluid input ends are connected with the quantitative pipelines; when in the second relative state , the quantitative pipelines are connected with the fluid receiving ends; and preferably , the fluid control mechanism is a microfluidic mechanism.2. The fluid control mechanism of claim 1 , wherein the fluid input ends and the fluid receiving ends are disposed in a staggered manner; when in the first relative state claim 1 , the quantitative pipelines are not connected with the fluid receiving ends; when in the second relative state claim 1 , the quantitative pipelines are not connected with the fluid input ends; and in a process of switching from the first relative state to the second relative state claim 1 , two ends of the quantitative pipelines are kept ...

Microfluidic injection and manifold assembly

A microfluidic injection and manifold assembly includes a microfluidic chip having at least a first fluid port and a second fluid port, and a fluid pathway between the first fluid port and the second fluid port. A manifold has a seat on which the microfluidic chip is received, and at least a first fluid channel. The fluid channel has an external fluid port spaced from the seat and an internal fluid port in the seat and connected in fluid communication with the first fluid port of the microfluidic chip. At least a first injector is secured to the manifold and has a plunger and a drive assembly. The drive assembly is activatable to force the plunger into the external fluid port of the manifold to force fluid from the first fluid channel of the manifold into the fluid pathway of the microfluidic chip.

Method for processing polynucleotide-containing samples

Methods and systems for processing polynucleotides (e.g., DNA) are disclosed. A processing region includes one or more surfaces (e.g., particle surfaces) modified with ligands that retain polynucleotides under a first set of conditions (e.g., temperature and pH) and release the polynucleotides under a second set of conditions (e.g., higher temperature and/or more basic pH). The processing region can be used to, for example, concentrate polynucleotides of a sample and/or separate inhibitors of amplification reactions from the polynucleotides. Microfluidic devices with a processing region are disclosed.

CUSTOMIZABLE MICROFLUIDIC DEVICE WITH PROGRAMMABLE MICROFLUIDIC NODES

The invention is directed to a microfluidic device. The device includes an input microchannel, a set of m distribution microchannels, a set of m microfluidic modules and a set of m nodes. The m microfluidic modules (m≥2) are in fluidic communication with the m distribution microchannels, respectively. The one or more nodes of the set of m nodes branch from the input microchannel, and further branch to a respective one of the set of m distribution microchannels. In addition, a subset, but not all, of the nodes are altered. The nodes of the set of m nodes have different liquid pinning strengths. As a result, the extent in which a liquid passes through one or more of the m microfluidic modules varies based on the different liquid pinning strengths, in operation. Additional sets of nodes may be provided to allow liquid to pass through ordered pairs of modules. 1. A microfluidic device comprising:an input microchannel;a set of m distribution microchannels, m≥2;a set of m microfluidic modules, in fluidic communication with the set of m distribution microchannels, respectively; and 'a subset, but not all, of the set of m nodes are altered, compared with remaining nodes of the set of m nodes, whereby the nodes in the set of m nodes have different liquid pinning strengths, such that the extent in which a liquid introduced in the input microchannel passes through one or more of the set of m microfluidic modules varies based on the different liquid pinning strengths, in operation.', 'a set of m nodes, wherein one or more of the set of m nodes branches from the input microchannel and further branches to a respective one of the set of m distribution microchannels, to potentially ensure fluidic communication from the input microchannel to the respective one of the set of m distribution microchannels it branches to, wherein'}2. The microfluidic device according to claim 1 , whereinthe subset of the set of m nodes are altered, compared with remaining nodes of the set of m nodes, ...

Valved Cartridge and System

This disclosure provides, among other things, a cartridge comprising: (a) a cartridge body comprising a malleable material and having, disposed on a surface of the body, at least one valve body comprising a valve inlet and a valve outlet, each fluidically connected to a fluidic channel; and (b) a layer comprising a deformable material bonded to a surface of the cartridge body and sealing the at least one valve body at points of attachment, thereby forming at least one valve; wherein the at least one valve body is depressed in the cartridge body relative to the points of attachment and wherein the deformable material covering the at least one valve body retains sufficient elasticity after deformation such that in a ground state the valve is open. Also disclosed is an instrument comprising a cartridge interface and a cartridge as described herein engaged with the cartridge interface, wherein (II) the cartridge interface comprises: (A) at least one mechanical actuator, each mechanical actuator positioned to actuate a valve; and (B) at least one motor operatively coupled to actuate a mechanical actuator toward or away from a valve. 1. A method of making an article comprising:(a) providing a cartridge body comprising a malleable material and having, disposed on a surface of the body, at least one valve body comprising a valve inlet and a valve outlet, each fluidically connected to a fluidic channel; and(b) providing a layer comprising a deformable material;(c) bonding the layer to the surface to seal the at least one valve body at points of attachment, thereby forming at least one valve, wherein the at least one valve body is depressed in the cartridge body relative to the points of attachment; and(d) deforming the deformable layer covering the at least one valve body wherein the deformable layer undergoes plastic deformation and retains sufficient elasticity such that in a ground state the valve is open.2. The method of claim 1 , wherein bonding comprises heat sealing ...

Photocurable perfluoropolyethers for use as novel materials in microfluidic devices

A solvent-resistant microfluidio device (MD) is fabricated from a functionalized, photo-curable perfluoropolyether (PFPE). In one embodiment, a polymeric precursor (PP), comprising PFPE, is disposed on a patterned surface (PS) of a substrate (S), having raised protrusions (P). Ultraviolet light (UV) is applied to yield a patterned layer (PL) of photo-cured PFPE having recesses (R) comprising at least one channel (CH). Patterned layer (PL) is removed from patterned surface (PS) of substrate (S) to yield microfluidic device (MD).

Microfluidic pump and valve structures and fabrication methods

Plastic microfluidic structures having a substantially rigid diaphragm that actuates between a relaxed state wherein the diaphragm sits against the surface of a substrate and an actuated state wherein the diaphragm is moved away from the substrate. As will be seen from the following description, the microfluidic structures formed with this diaphragm provide easy to manufacture and robust systems, as well readily made components such as valves and pumps.

Membrane-based fluid control in microfluidic devices

A microfluidic device may include a substrate (410) that defines a flow-control cavity (420) and first (430) and second (440) channels in fluid communication with the flow-control cavity. A compliant membrane (450) for regulating fluid flow through the flow-control cavity may surround at least a portion of the flow-control cavity.

Micromechanical flow limiter with multilayer structure, e.g. for medical infusion system - has intermediate diaphragm layer which deflects w.r.t. amount of flowing medium, and blocks flow for large flow amounts

The micromechanical flow limiter is formed from three layers (1,2,3) fixed on top of one another. The middle layer (2) functions as a diaphragm and comprises a flat structure with a central opening (8). On both sides of the opening, walls (9,10) block or open the flow path. The flow limiter operates passively, without an actuator. The limiter is controlled by the prevailing pressure differences. In order to increase its reliability, additional micromechanical elements may be coupled to the multilayer structure. USE - For preventing back-flow in medical dispensing systems. Also for laboratory, motor vehicle, aircraft or space vehicle use or for pneumatic controllers.

Valve and micropump incorporating said valve

Photocurable perfluoropolyethers for use as novel materials in microfluidic devices

A solvent-resistant microfluidio device (MD) is fabricated from a functionalized, photo-curable perfluoropolyether (PFPE). In one embodiment, a polymeric precursor (PP), comprising PFPE, is disposed on a patterned surface (PS) of a substrate (S), having raised protrusions (P). Ultraviolet light (UV) is applied to yield a patterned layer (PL) of photo-cured PFPE having recesses (R) comprising at least one channel (CH). Patterned layer (PL) is removed from patterned surface (PS) of substrate (S) to yield microfluidic device (MD).

Method for processing polynucleotide-containing samples

Methods and systems for processing polynucleotides (e.g., DNA) are disclosed. A processing region includes one or more surfaces (e.g., particle surfaces) modified with ligands that retain polynucleotides under a first set of conditions (e.g., temperature and pH) and release the polynucleotides under a second set of conditions (e.g., higher temperature and/or more basic pH). The processing region can be used to, for example, concentrate polynucleotides of a sample and/or separate inhibitors of amplification reactions from the polynucleotides. Microfluidic devices with a processing region are disclosed.

Thermal microvalves in a fluid flow method

The movement and mixing of microdroplets through microchannels is described employing silicon-based microscale devices, including microdroplet transport channels, reaction regions, electrophoresis modules, and radiation detectors. The discrete droplets are differentially heated and propelled through etched channels. Electronic components are fabricated on the same substrate material, allowing sensors and controlling circuitry to be incorporated in the same device.

Processing polynucleotide-containing samples

Methods and systems for processing polynucleotides (e.g., DNA) are disclosed. A processing region includes one or more surfaces (e.g., particle surfaces) modified with ligands that regain polynucleotides under a first set of conditions (e.g., temperature and pH) and release the polynucleotides under a second set of conditions (e.g., higher temperature and/or more basic pH). The processing region can be used to, for example, concentrate polynucleotides of a sample and/or separate inhibitors of amplification reactions from the polynucleotides. Microfluidic devices with a processing region are disclosed.

Method for processing polynucleotide-containing samples

Methods and systems for processing polynucleotides (e.g., DNA) are disclosed. A processing region includes one or more surfaces (e.g., particle surfaces) modified with ligands that retain polynucleotides under a first set of conditions (e.g., temperature and pH) and release the polynucleotides under a second set of conditions (e.g., higher temperature and/or more basic pH). The processing region can be used to, for example, concentrate polynucleotides of a sample and/or separate inhibitors of amplification reactions from the polynucleotides. Microfluidic devices with a processing region are disclosed.

Passive microvalve

Chemical assays

An assay device in which to carry out a fluid-phase chemical assay, comprising means for supporting a test substrate, a sample chamber for receiving a fluid sample and at least one fluid control device for controlling the movement of fluid into and/or out of the sample chamber, wherein the fluid control device comprises a fluid outlet chamber in fluid communication with the sample chamber, and a displaceable flexible diaphragm the displacement of which alters the volume of the outlet chamber so as to allow and/or restrict fluid flow between the outlet and sample chambers. The invention also provides assay apparatus incorporating such a device, an assay station for use as part of such apparatus, a fluid control unit for use as part of the assay device and a method of conducting an assay which may involve the use of such apparatus and devices.

Electrofluidic standard module and custom circuit board assembly

A miniature electrofluidic module is disclosed, for receiving one or more fluids and for receiving an electrical connection. In accordance with one aspect of the invention, the module includes a substantially flat fluidic manifold layer for fluid distribution, a substantially flat electrical layer including an electrical circuit, and a substantially flat device layer including micromachined devices. The devices may include electrically actuated valves for modulating the flow of fluids. In another aspect of the invention, an electrofluidic module is combined with an electrofluidic circuit board. In a further aspect, an electrofluidic system such as a dialysate handling system is disclosed, including a fluidic fixture and an electrofluidic assembly incorporating electrofluidic devices. In a still further aspect of the invention, a method is disclosed for interfacing micromachined devices to electrical and fluidic interfaces on a fixture, including packaging the devices into a module and providing electrical and fluidic interfaces between the module and the fixture.

Valve assembly for microfluidic devices, and method for opening and closing the same

A normally open fluid manipulation valve assembly and system and a method for closing, re-opening and re-closing same. The normally open valve assembly can include a substrate including a first surface, with first and second recesses formed in the first surface. A recessed channel can be formed in the first surface. The recessed channel can extend from the first recess to the second recess and can be at least partially defined by a first deformable material having a first modulus of elasticity. The valve assembly can also include an elastically deformable cover. The elastically deformable cover can include a layer of an elastically deformable material having a modulus of elasticity that is greater than the modulus of elasticity of the first deformable material, and an adhesive layer that contacts the first surface of the substrate.

Membrane pump with stretchable pump membrane

The invention relates to membrane pumps for delivering liquids. More specifically, a pump is provided having a pump housing with a pump cavity formed between first and second wall portions thereof, and an pump membrane pump membrane having first and second membrane surfaces arranged within the pump cavity, whereby a pump chamber is provided between the first wall portion and the first membrane surface, and an actuation chamber is provided between the second wall and the second membrane surface. Inlet means comprising an inlet valve in fluid communication with the pump chamber, and outlet means comprising an outlet valve in fluid communication with the pump chamber are provided. The pump membrane has a maximum volume position, and a drained volume position in which the first membrane surface in a stretched state abuts the first wall. To drive the membrane, actuating means for periodically shifting the pump membrane between the maximum volume position and the drained volume position is provided, thereby, in a situation of use, providing a flow of fluid.

Microfluidic pump and valve structures and fabrication methods

Plastic microfluidic structures having a substantially rigid diaphragm that actuates between a relaxed state wherein the diaphragm sits against the surface of a substrate and an actuated state wherein the diaphragm is moved away from the substrate. As will be seen from the following description, the microfluidic structures formed with this diaphragm provide easy to manufacture and robust systems, as well readily made components such as valves and pumps.

Membrane pump with stretchable pump membrane

The invention relates to membrane pumps for delivering liquids. More specifically, a pump is provided having a pump housing with a pump cavity formed between first and second wall portions thereof, and an pump membrane pump membrane having first and second membrane surfaces arranged within the pump cavity, whereby a pump chamber is provided between the first wall portion and the first membrane surface, and an actuation chamber is provided between the second wall and the second membrane surface. Inlet means comprising an inlet valve in fluid communication with the pump chamber, and outlet means comprising an outlet valve in fluid communication with the pump chamber are provided. The pump membrane has a maximum volume position, and a drained volume position in which the first membrane surface in a stretched state abuts the first wall. To drive the membrane, actuating means for periodically shifting the pump membrane between the maximum volume position and the drained volume position is provided, thereby, in a situation of use, providing a flow of fluid.

Membrane pump with stretchable pump membrane

The invention relates to membrane pumps for delivering liquids. More specifically, a pump is provided having a pump housing with a pump cavity formed between first and second wall portions thereof, and an pump membrane pump membrane having first and second membrane surfaces arranged within the pump cavity, whereby a pump chamber is provided between the first wall portion and the first membrane surface, and an actuation chamber is provided between the second wall and the second membrane surface. Inlet means comprising an inlet valve in fluid communication with the pump chamber, and outlet means comprising an outlet valve in fluid communication with the pump chamber are provided. The pump membrane has a maximum volume position, and a drained volume position in which the first membrane surface in a stretched state abuts the first wall. To drive the membrane, actuating means for periodically shifting the pump membrane between the maximum volume position and the drained volume position is provided, thereby, in a situation of use, providing a flow of fluid.

Passive microvalve

A passive microvalve comprises a substrate having a first aperture. An upper plate is mounted on the substrate and has a second aperture opening into a space defined between the substrate and the upper plate. A closure member is mounted in the space and is movable between a first position in which it allows fluid flow between the first and second apertures and a second position in which it closes the second aperture.

Membrane pump with stretchable pump membrane

The invention relates to membrane pumps for delivering liquids. More specifically, a pump is provided having a pump housing with a pump cavity formed between first and second wall portions thereof, and an pump membrane pump membrane having first and second membrane surfaces arranged within the pump cavity, whereby a pump chamber is provided between the first wall portion and the first membrane surface, and an actuation chamber is provided between the second wall and the second membrane surface. Inlet means comprising an inlet valve in fluid communication with the pump chamber, and outlet means comprising an outlet valve in fluid communication with the pump chamber are provided. The pump membrane has a maximum volume position, and a drained volume position in which the first membrane surface in a stretched state abuts the first wall. To drive the membrane, actuating means for periodically shifting the pump membrane between the maximum volume position and the drained volume position is provided, thereby, in a situation of use, providing a flow of fluid.

Membrane-based fluid control in microfluidic devices

A microfluidic device may include a substrate that defines a flow-control cavity and first and second channels in fluid communication with the flow-control cavity. A compliant membrane for regulating fluid flow through the flow-control cavity may surround at least a portion of the flow-control cavity.

Membrane-based fluid control in microfluidic devices

A microfluidic device may include a substrate that defines a flow-control cavity and first and second channels in fluid communication with the flow-control cavity. A compliant membrane for regulating fluid flow through the flow-control cavity may surround at least a portion of the flow-control cavity.

Membrane-based fluid control in microfluidic devices

A microfluidic valve system includes a substrate, a valve seat a compliant membrane and a mechanically actuable displacement element. The substrate includes first and second channels embedded within it and includes a first layer of material and a second layer of material. The valve seat is in fluid communication with the first and second channels. Portions of the second layer of material form sidewalls of the second channel and the valve seat. The mechanically actuable displacement element applies a mechanical force to the compliant membrane to bring the compliant membrane into sealable contact with the valve seat, thereby closing the valve system.

Valve equipped with a position detector and a micropump incorporating said valve

A valve is formed from a silicon wafer (20). A position detector having a first electrical contact (54) formed on a glass support (32) mounted on the back face of the wafer (20), a second electrical contact fixed to the wafer (20) and a electrical impedance measurement circuit(resistance or capacitance according to the embodiment) between the two electrical contacts is provided to detect by contact the position of the valve and hence reveal any malfunction Useful in micropump for the injection of medicaments.

Micromachined filters

MEMS device and method for delivery of therapeutic agents

Embodiments of an implantable device for delivering a therapeutic agent to a patient includes a reservoir configured to contain a liquid comprising the therapeutic agent and a cannula in fluid communication with the reservoir. The device and related methods may provide such features as constant-flow operation, an electrolytic mode of pumping, and/or wireless communication.

MEMS device and method for delivery of therapeutic agents

Embodiments of an implantable device for delivering a therapeutic agent to a patient include a reservoir configured to contain a liquid comprising the therapeutic agent, and a cannula in fluid communication with the reservoir. The cannula is shaped to facilitate insertion thereof into a patient's eyeball.

MEMS device and method for delivery of therapeutic agents

Embodiments of an implantable device for delivering a therapeutic agent to a patient include a reservoir configured to contain a liquid comprising the therapeutic agent, and a cannula in fluid communication with the reservoir. The cannula is shaped to facilitate insertion thereof into a patient's eyeball.

Membrane-based fluid control in microfluidic devices

A microfluidic device may include a substrate (410) that defines a flow-control cavity (420) and first (430) and second (440) channels in fluid communication with the flow-control cavity. A compliant membrane (450) for regulating fluid flow through the flow-control cavity may surround at least a portion of the flow-control cavity.

Valve equipped with a position detector and a micropump incorporating said valve

A valve is formed from a silicon wafer (20) and has a position detector to detect by contact the position of the valve and hence reveal any malfunction. The position detector comprises a first electrical contact (54) formed on a glass support (32) mounted on the back face of the wafer (20), a second electrical contact fixed to the wafer (20) and an electrical impedance measurement circuit (resistance or capacitance according to the embodiment) between the two electrical contacts. The valve is useful in a micropump for the injection of medicaments.

Micro diaphragm pump

The invention relates to a micromembrane pump comprising a pump membrane (110; 122) which can be moved into a first and a second position by means of a drive device (100; 120) and a pump body (102; 104; 104') connected to said pump membrane (110; 122) so as to define a pumping chamber (112) between them. The pump body (102; 104; 104') is configured as two semi-conductor wafers in each of which a valve seat and a valve flap are embodied as a single piece. The two semi-conductor wafers are joined in such a way that a passive return valve (106, 108) is formed by a valve seat of the one semi-conductor wafer and a valve flap of the other semi-conductor wafer, where one (106) of the passive return valves (106, 108) is arranged in an inlet opening passing through both semi-conductor wafers while the other (108) of the passive return valves (106, 108) is arranged in an outlet opening passing through both semi-conductor wafers. When the pump membrane (110; 122) moves from the first into the second position it enlarges the volume (V0) of the pumping chamber by a displacement volume ( DELTA V) and reduces the volume of the pumping chamber (112) by said displacement volume when moving from the second into the first position. According to the invention, when the pump membrane (110; 122) is in the first position the ratio epsilon of the displacement volume ( DELTA V) to the volume (V0) of the pumping chamber (112) corresponds to the following equation (a), where p0 is atmospheric pressure, gamma is the adiabatic coefficient and DELTA pcrit is the maximum pressure, dependent on valve geometry and valve wetting, required to open the valves.

Microstructure device for storing small amounts of liquid and method for collecting liquid stored in this device

Mikrostrukturierte Vorrichtung zum entnehmbaren Speichern von kleinen Flüssigkeitsmengen mit folgenden Merkmalen: - die Vorrichtung weist einen Träger (1) auf; - die Vorrichtung weist einen ersten Hohlraum (4) mit zumindest einem ersten Abschnitt zum Speichern der kleinen Flüssigkeitsmenge auf; - der erste Abschnitt des ersten Hohlraums (4) ist in den Träger (1) eingeformt; - der erste Abschnitt ist mit einem Deckelelement (2) und einem Sperrelement (3) verschlossen; - die Vorrichtung weist ein Mittel zur Übertragung einer Kraft von dem Deckelelement (2) zu dem Sperrelement (3) auf, welche eine Verbindung zwischen dem Sperrelement und dem Träger so zerstört oder das Sperrelement so zerstört, dass die Flüssigkeitsmenge aus dem ersten Abschnitt des Hohlraums (4) entnehmbar ist. Microstructured device for removably storing small quantities of liquid, having the following features: - The device has a carrier (1); - The device comprises a first cavity (4) with at least a first portion for storing the small amount of liquid; - The first portion of the first cavity (4) is formed in the carrier (1); - The first portion is closed with a cover element (2) and a locking element (3); - The device has a means for transmitting a force from the lid member (2) to the blocking element (3), which destroys a connection between the blocking element and the carrier so or destroyed the blocking element, that the amount of liquid from the first portion of the cavity (4) is removable.

MEMS device for delivery of therapeutic agents

Anti-return valve, particularly for micropump and micropump provided with such a valve

The body of the anti-return valve is formed within a silicon plate (1) machined by photolythographic processes. The plate (1) delimits a valve chamber (7) with two glass plates (2, 5) adhered to the respective sides of the plate (1). The chamber is divided into two compartments (8, 9) by means of a shutter of general planar shape having an annular rib (12) in a central region. The shutter is comprised of means for connection to the body of the valve formed by at least two connection members (11a, 11b) which leave between them at least one opening (14a, 14b) for communication of the two compartments of the valve chamber. Application to micropumps, particularly for the precise metering of small amounts of drugs to be injected.

Fluid control microdevice and manufacturing method

Mikroventil mit einem normalerweise geschlossenen zustand

Ein Mikroventil mit einem normalerweise geschlossenen Zustand umfaßt eine Membran (80), eine Betätigungseinrichtung (100) zur steuerbaren Deformation der Membran (80) sowie einen durch die steuerbare Deformation der Membran (80) verformbaren Ventilverschluß (180). Der Ventilverschluß (180) liegt der Membran (80) zumindest teilweise gegenüber und liegt in einer ersten Stellung in dem normalerweise geschlossenen Zustand des Ventils entlang einer zwischen dem Ventilverschluß (180) und der Membran angeordneten Dichtlippe (130) auf. Die Dichtlippe (130) ist derart angeordnet, daß ein Auslaß des Ventils, der mit einem unterbrochenen Abschnitt der Dichtlippe (130) fluidmäßig verbunden ist, gegen einen Eingangskanal (170), der an den Ventilverschluß (180) angrenzt, fluiddicht abgeschlossen ist. Darüber hinaus ist der Ventilverschluß in eine zweite Stellung formbar, um in einem offenen Zustand des Ventils den Auslaß (140) mit dem Eingangskanal (170) fluidmäßig zu verbinden.

Micromachined fluid handling devices

The fluid handling devices are capable of accurately handling substantially continuous fluid flow rates as low as about 0.01 cc/day. The devices are so miniaturized, corrosion-resistant and non-toxic that they are suitable for being implanted in the human body; and are capable of being mass produced at costs so low, by using micromachining techniques, such as etching, that they may be considered to be disposable. The devices are either passive devices which consume no electrical energy at all, or are active devices which consume very small amounts of electrical energy. The devices are reliable because they may have as few as only two parts, only one which is a moving part; and because they may handle fluids at very low pressures. The fluid handling devices include active piezoelectrically driven membrane pumps; and passive fluid flow regulators, on-off valves, flow switches and filters.

用于测试样品的储物筒、分析系统和方法

提出了用于分析特别是生物样品的储物筒、分析系统和方法，其中具有一个或多个阀的第一群组和具有一个或多个阀的第二群组从储物筒的不同侧面可以被致动或被致动。

Magnetic microvalve using metal ball and manufacturing method thereof

본 발명은 금속볼을 이용한 자기력 마이크로밸브 및 그 제조방법에 관한 것으로, 상기 자기력 마이크로밸브는, 유체가 이동하는 통로인 마이크로채널과, 상기 마이크로채널로의 유체의 유입을 위한 유체입구와, 상기 마이크로채널을 통과한 유체의 유출을 위한 유체출구가 형성된 상부기판; 내부 영역에 국부적으로 트렌치가 형성된 하부기판; 금속볼이 중앙부에 위치하고 PDMS가 상기 금속볼을 둘러싸도록 구성되며, 상기 하부기판에 형성된 트렌치에 삽입되는 PDMS/금속볼 결합체; 및 상기 상부기판에 형성된 마이크로채널의 상부에 위치하여 자기력을 발생하는 자석을 포함하여 구성된다. The present invention relates to a magnetic force microvalve using a metal ball and a method for manufacturing the magnetic force, the magnetic force microvalve includes a microchannel which is a passage through which a fluid moves, a fluid inlet for inflow of fluid into the microchannel, and the microchannel. An upper substrate having a fluid outlet for outflow of the fluid passing through the channel; A lower substrate having a trench formed locally in the inner region; A PDMS / metal ball assembly in which a metal ball is positioned at the center portion and the PDMS surrounds the metal ball and is inserted into a trench formed in the lower substrate; And a magnet positioned above the microchannel formed on the upper substrate to generate a magnetic force. 자기력 마이크로밸브, PDMS, 금속볼, PDMS/금속볼 결합체 Magnetic force microvalve, PDMS, metal ball, PDMS / metal ball combination

Microválvula e processo para a fabricação de uma microválvula

fluid switching devices

유체 디바이스는 소스로부터 드레인으로 채널에서의 유체 흐름을 제어한다. 일부 실시예들에서, 유체 디바이스들은 게이트, 채널, 및 방해물(obstruction)을 포함한다. 게이트는 체적이 유체 압력에 따라 증가하는 적어도 하나의 챔버를 포함한다. 게이트의 고압 상태는 제 1 챔버 크기에 대응하고 게이트의 저압 상태는 제 1 챔버 크기보다 작은 제 2 챔버 크기에 대응한다. 방해물은 게이트에서 유체 압력에 기초하여 채널 내의 유체 흐름의 레이트를 제어한다. 방해물은 게이트의 저압 상태에 따라 채널에서 기껏해야 유체의 제 1 유량, 및 게이트의 고압 상태에 따라 채널에서 적어도 유체의 제 2 유량을 유도한다. A fluid device controls fluid flow in a channel from a source to a drain. In some embodiments, the fluidic devices include a gate, a channel, and an obstruction. The gate includes at least one chamber whose volume increases with fluid pressure. The high pressure state of the gate corresponds to a first chamber size and the low pressure state of the gate corresponds to a second chamber size that is smaller than the first chamber size. The obstruction controls the rate of fluid flow in the channel based on the fluid pressure at the gate. The obstruction induces at most a first flow rate of fluid in the channel depending on the low pressure condition of the gate, and at least a second flow rate of fluid in the channel depending on the high pressure condition of the gate.

Patent JPH0450471B2

Processing of samples containing polynucleotides

마이크로밸브 및 그 제조방법(Micro-valve and process for manufacturing a micro-valve)

본 발명의 마이크로 밸브(1)는 서로 고정적으로 결합되고 또한 서로 별개로 제조되는 전자 구동장치(2)와 다충형의 밸브 하부부분(17)으로 이루어져 있다. 밸브 하부부분(17)은 최소한 1개의 자극자(18) 및 축방향으로 가동의 밸브 폐쇄 소자(20) 및 마이크로 밸브(1)의 축방향 가동의 구성부분을 최소한 부분적으로 에워싸는 케이스(12)를 갖추고 있다. 밸브 하부부분(17)은 금속 전도 석출에 의해 차례로 상하에 구성된다(다층전도법). 본 발명의 마이크로 밸브는 예를들면 내연기관의 연료 분사 장치로 사용하기에 적합하다.

Digital bio disc dbd, dbd driver apparatus, and assay method using the same

The present invention relates to a digital bio disc, a digital bio disc driver device including a novel valve control means, and an analysis method using the same, and more particularly, to various diagnostic analysis devices, nucleic acid hybrid analysis devices, immunological verification devices, and the like. Digital bio-disc, which has a Lab On a Chip designed and arranged, and a digital bio-disc driver device having a conventional optical disc (CD and DVD) and a control unit for controlling and driving the digital bio-disc, and an analysis method using the same. It is about.

阀装置

本发明涉及包括基体(12)和弹性膜(13)的阀装置(10)，所述膜至少在阀区域周围被结合到基体上。基体包括第一通道(16)和第二通道(17)，第一通道和第二通道在阀区域中终止，第一通道在阀区域中具有第一通道端面(19)、且第二通道在阀区域中具有第二通道端面(21)，其中第一通道端面的面积大体上大于第二通道端面的面积。

一种微流控芯片检测用微流控阀阀组

本发明涉及一种微流控芯片检测用微流控阀阀组。微流控芯片检测用微流控阀阀组包括底座，底座上在水平面上位置可调的装配有至少两个微流控阀，各微流控阀分别包括阀体及往复活动装配在阀体上以控制相应微流控芯片的微流通道通断的阀芯，阀芯上连接有拉绳，拉绳上连接有拉绳牵引机构，所述阀体中还设置有向阀芯施加弹性作用力以与拉绳配合驱动所述阀芯往复动作的弹性件。本发明解决了现有气动式微流控阀占用体积大以及电磁式微流控阀布置于微流控芯片下方发热量大的问题，同时本发明的微流控阀阀组的至少两个微流控阀在底座上的位置可调，使得通过调整微流控阀的位置可适用于不同的微流控芯片，具有较好的通用性。

用于测试样品的储物筒、分析系统和方法

提出了用于分析特别是生物样品的储物筒、分析系统和方法，其中具有一个或多个阀的第一群组和具有一个或多个阀的第二群组从储物筒的不同侧面可以被致动或被致动。

Micro-channel air valve

PURPOSE: A micro-channel air valve is provided to control the flow rate of fluid and to adjust mixed flow rate when mixing more than two kinds of fluids in a lab on a chip through a micro-channel. CONSTITUTION: A micro-channel air valve comprises a valve body, a micro-channel(20), a flow path control channel(30), and an air bubble channel. The micro-channel is connected to a valve body with a fluid supply source to form a flow path in which fluid flows. The volume of the flow path control channel is larger than the micro-channel. One end of the air bubble channel is connected to the air bubble supplying unit and the other end thereof is connected to the flow path control channel so that air bubbles can be supplied to or discharged from the flow path control channel.

Micro valve

Compact valve

형상기억합금을 사용한 소형밸브에 있어서, 오리피스(2)를 내장한 가이드파이프(1) 안에, 가이드파이프(1)에 내접한 오리피스(2)를 봉지하는 봉지부(5)를 갖는 가동이 가능한 가동밸브체(3)와, 오리피스(2)와 가동밸브체(3) 사이에 배치한 바이어스코일(8)과, 가이드파이프(1)의 고정전극(11)과 가동밸브체(3)의 가동전극(3) 간에 파지된 형상기억합금으로 이루어진 와이어(9)를 구비하고, 와이어(9)를 가열하여 형상기억합금을 변형시킴으로써 가동밸브체(3)를 가동시켜서 오리피스(2)를 봉지하고, 가동밸브체(3)에 응력저감용의 코일용수철(7)을 배치하여 탄성적변형을 가능하게 하며, 와어어(9)의 과잉수축에 의한 가동밸브체(3)로의 과부하를 가동밸브체(3)의 탄성변형에 의해 흡수한다. 이로써, 형상기억합금의 과부하를 저감하여, 기억형상의 재현성의 열화를 방지하여, 내구성을 향상하고, 신뢰성을 높인다. In a small valve using a shape memory alloy, a movable member having a sealing portion (5) for sealing an orifice (2) inscribed in the guide pipe (1) in a guide pipe (1) incorporating an orifice (2). The valve body 3, the bias coil 8 disposed between the orifice 2 and the movable valve body 3, the fixed electrode 11 of the guide pipe 1 and the movable electrode of the movable valve body 3; (3) having a wire 9 made of a shape memory alloy held between them, heating the wire 9 to deform the shape memory alloy to activate the movable valve body 3 to seal the orifice 2, and The coil spring 7 for stress reduction is arranged in the valve body 3 to enable elastic deformation, and the overload of the wire 9 to the movable valve body 3 due to excessive shrinkage of the wire 9 is prevented from the movable valve body 3. Absorption is caused by elastic deformation. This reduces the overload of the shape memory alloy, prevents deterioration of the reproducibility of the memory shape, improves durability, and enhances reliability. 소형밸브, 형상기억합금 Small Valve, Shape Memory Alloy

Microfluidic devices and methods for chemical assays

An assay device in which to carry out a fluid-phase chemical assay, comprising means for supporting a test substrate, a sample chamber for receiving a fluid sample and at least one fluid control device for controlling the movement of fluid into and/or out of the sample chamber, wherein the fluid control device comprises a fluid outlet chamber in fluid communication with the sample chamber, and a displaceable flexible diaphragm the displacement of which alters the volume of the outlet chamber so as to allow and/or restrict fluid flow between the outlet and sample chambers. The invention also provides assay apparatus incorporating such a device, an assay station for use as part of such apparatus, a fluid control unit for use as part of the assay device and a method of conducting an assay which may involve the use of such apparatus and devices.

Processing of polynucleotide-containing samples

【課題】ポリヌクレオチド含有サンプルを処理する方法及びシステムを提供すること。 【解決手段】ポリヌクレオチド（例えば、ＤＮＡ）を処理する方法及びシステムが開示される。処理領域は、リガンドで改質された１つ又は２つ以上の表面（例えば、粒子表面）を有し、リガンドは、ポリヌクレオチドを第１の組をなす条件（例えば、温度及びｐＨ）下で回復させ、ポリヌクレオチドを第２の組をなす条件（例えば、高い温度及び（又は）より基本的なｐＨ）下で放出する。例えばサンプルのポリヌクレオチドを濃縮すると共に（或いは）増幅反応の抑制物質をポリヌクレオチドから分離するのに処理領域を利用することができる。処理領域を備えたマイクロフルイディック（microfluidic）デバイスが開示される。 【選択図】図４

Multiplexed latching valves for microfluidic devices and processors

Membrane valves and latching valve structures for microfluidic devices are provided. A demultiplexer can be used to address the latching valve structures. The membrane valves and latching valve structures may be used to form pneumatic logic circuits, including processors.

Microvalve normally in a closed position

A microvalve with a normally closed state includes a membrane, an actuation means for controllable deformation of the membrane as well as a valve shutter deformable by the controllable deformation of the membrane. The valve shutter at least partially opposes the membrane and rests, in a first position in the normally closed state of the valve, along a sealing lip arranged between the valve shutter and the membrane. The sealing lip is arranged such that an outlet of the valve, which outlet is in fluid communication with an interrupted section of the sealing lip, is sealed against an input channel bordering on the valve shutter. In addition, the valve shutter is moldable into a second position so as to bring the outlet into fluidic communication with the input channel in an open state of the valve.

Microfluidic device and control system for the same

A platform provided with a plurality of chambers, at least one flow path connecting the chambers, and a valve for opening and closing the flow path, so that the valve for adjusting the flow of the fluid can be operated more easily and mechanically, The valve includes a blocking member for selectively blocking the flow path, and a pressing member provided on the blocking member to move the blocking member. The pressing member linearly reciprocates in the same direction as the external force, And the valve further comprises a driving unit for reversibly controlling the opening and closing of the flow path by the blocking member by fixing the pressing member to the moved position or returning it to the home position.

Multiplexed latching valves for microfluidic devices and processors

本发明提供用于微流控器件的隔膜阀和自锁阀结构。可以使用多路复用器来寻址自锁阀结构。可使用隔膜阀和自锁阀结构来形成包括处理器在内的气动逻辑线路。

Device having a reversibly closable fluid valve

A device comprising a valve in a tubular channel (3) to open and close said channel (3), said valve being formed by a first wall (2) of said tubular channel, said first wall (2) being made of a thermoplastic elastomeric material, and a second wall being made of a thermoplastic material, said first wall (2) and said second wall being irreversibly bonded to each other is disclosed. The device can be used advantageously for reliable analyses in automated procedures, e.g., to control fluid flows within said device.

Micro valve normally in a closed position

Digital bio disc(DBD), DBD driver apparatus, and assay method using the same

本发明公开了一种包括新的阀控制单元和液体流动系统的数字生物盘(DBD)、一种数字生物盘(DBD)驱动器装置、以及相应的应用化验方法。特别地，本发明涉及一种数字生物盘(DBD)，其具有用于各种诊断化验、核酸杂交化验或是免疫化验的芯片上实验室；一种DBD驱动器装置，其集成有用于控制数字生物盘(DBD)和通用光盘(CD或DVD)的控制器；以及相应的应用化验方法。

Micro valve and its manufacturing method

본 발명의 마이크로 밸브(1)는 서로 고정적으로 결합되고 또한 서로 별개로 제조되는 전자 구동장치(2)와 다층형의 하부 밸브 부분(17)으로 이루어져 있다. 하부 밸브 부분(17)은 최소한 1 개의 전기자(18) 및 축방향으로 가동의 밸브 폐쇄 소자(20) 및 마이크로 밸브(1)의 축방향 가동의 구성부분을 최소한 부분적으로 에워싸는 케이싱(12)을 갖추고 있다. 하부 밸브 부분(17)은 금속 전도 석출에 의해 차례로 상하에 구성된다(다층전도법). The microvalve (1) of the present invention comprises an electromagnetic drive device (2) fixedly coupled to one another and manufactured separately from each other and a multi-layered lower valve portion (17). The lower valve portion 17 has at least one armature 18 and an axially movable valve closing element 20 and a casing 12 which at least partly surrounds the constituent parts of the axial movement of the microvalve 1 have. The lower valve portion 17 is formed up and down in turn by metal conduction deposition (multi-layer conduction method). 본 발명의 마이크로 밸브는 예를 들면 내연기관의 연료 분사 장치로 사용하기에 적합하다. The microvalve of the present invention is suitable for use as, for example, a fuel injection device of an internal combustion engine.

Miniature valve and method of making same

In a miniature valve, a valve seat is formed by aperturing a plate. A cantilever leaf spring is disposed overlying the apertured plate for controlling the flow of fluid therethrough. An electrostatic potential applied between the cantilever leaf spring and the valve plate pulls the leaf spring over the apertured plate for variably controlling flow through the valve in accordance with the magnitude of the applied potential. In a preferred embodiment, the cantilever leaf springs are made in batch form by etching a silicon wafer. A flow controller is provided by measuring the electrical capacitance of the valve, comparing it with a reference voltage and deriving a feedback voltage applied to the valve for controlling flow therethrough. In one embodiment, the width of the cantilever leaf spring valve member is narrowed toward its free end for finer control of flow.

Miniature actuator

High throughput screening of crystallization of materials

High throughput screening of crystallization of a target material is accomplished by simultaneously introducing a solution of the target material into a plurality of chambers of a microfabricated fluidic device. The microfabricated fluidic device is then manipulated to vary the solution condition in the chambers, thereby simultaneously providing a large number of crystallization environments. Control over changed solution conditions may result from a variety of techniques, including but not limited to metering volumes of crystallizing agent into the chamber by volume exclusion, by entrapment of volumes of crystallizing agent determined by the dimensions of the microfabricated structure, or by cross-channel injection of sample and crystallizing agent into an array of junctions defined by intersecting orthogonal flow channels.

Valves and pumps for microfluidic systems and method for making microfluidic systems

The present invention relates to microfluidic systems, including valves (12) and pumps for microfluidic systems. The valves of the invention include check valves (30) such as diaphragm valves and flap valves. Other valves of the invention include one-use valves (12). The pumps of the present invention include a reservoir (40) and at least two check valves (30, 31). The reservoir (40) may be a variable volume. The present invention also relates to a flexible microfluidic system (10). The present invention additionally relates to a method of making microfluidic systems (10) including those of the present invention. The method includes forming a microfluidic system on a master (100), connecting a support (110) to the microfluidic system (10) and removing the microfluidic system (10) from the master (100). The support (110) may remain connected to the microfluidic system (10) or the microfluidic system (10) may be transferred to another substrate. The present invention further relates to a method of manipulating a flow of a fluid in a microfluidic system. This method includes initiating fluid flow in a first direction (50) and inhibiting fluid flow in a second direction (50) and may be practiced with the valves (12) of the present invention.

Method and apparatus for the mechanical actuation of valves in fluidic devices

Mechanical actuation of valves in flexible fluidic structures allows for the regulation of fluid flow. In accordance with the disclosure herein, a fluidic structure is provided wherein mechanical actuation is conferred using a pin to actuate a flexible layer to occlude fluid flow in a fluid channel.

High throughput screening of crystallization materials

High throughput screening of crystallization of a target material is accomplished by simultaneously introducing a solution of the target material into a plurality of chambers of a microfabricated fluidic device. The microfabricated fluidic device is then manipulated to vary the solution condition in the chambers, thereby simultaneously providing a large number of crystallization environments. Control over changed solution conditions may result from a variety of techniques, including but not limited to metering volumes of crystallizing agent into the chamber by volume exclusion, by entrapment of volumes of crystallizing agent determined by the dimensions of the microfabricated structure, or by cross-channel injection of sample and crystallizing agent into an array of junctions defined by intersecting orthogonal flow channels.

Microfluidic Sieve Valves

Sieve valves for use in micorfluidic device are provided. The valves are useful for impeding the flow of particles, such as chromatography beads or cells, in a microfluidic channel while allowing liquid solution to pass through the valve. The valves find particular use in making microfluidic chromatography modules.

Micromachined parylene membrane valve and pump

A micromachined fluid handling device having improved properties. The valve is made of reinforced parylene. A heater heats a fluid to expand the fluid. The heater is formed on unsupported silicon nitride to reduce the power. The device can be used to form a valve or a pump. Another embodiment forms a composite silicone/parylene membrane. Another feature uses a valve seat that has concentric grooves for better sealing operation.

High throughput screening of crystallization materials

High throughput screening of crystallization of a target material is accomplished by simultaneously introducing a solution of the target material into a plurality of chambers of a microfabricated fluidic device. The microfabricated fluidic device is then manipulated to vary the solution condition in the chambers, thereby simultaneously providing a large number of crystallization environments. Control over changed solution conditions may result from a variety of techniques, including but not limited to metering volumes of crystallizing agent into the chamber by volume exclusion, by entrapment of volumes of crystallizing agent determined by the dimensions of the microfabricated structure, or by cross-channel injection of sample and crystallizing agent into an array of junctions defined by intersecting orthogonal flow channels.

Microfabricated fluidic circuit elements and applications

The present invention provides microfabricated fluidic systems and methods. Microfabricated fluidic devices of the present invention include switches that can be opened and closed to allow or block the flow of fluid through a channel in response to the pressure level in a gate of the switch. The microfabricated fluidic switches may be coupled together to perform logic functions and Boolean algebra, such as inverters, AND gates, NAND, gates, NOR gates, and OR gates. The logic gates may be coupled together to form flip-flops that latch signals. The present invention also includes microfabricated fluidic pressure multipliers that increase the pressure in a second chamber relative to a first chamber. Microfabricated fluidic devices of the present invention also include pressure sources. A pressure source of the present includes a pump coupled to a reservoir through unidirectional valves. The pressure source may be high pressure source or a low pressure source. Microfabricated fluidic devices of the present invention may also include devices that perform analog functions such as switching regulator.

High throughput screening of crystallization of materials

High throughput screening of crystallization of a target material is accomplished by simultaneously introducing a solution of the target material into a plurality of chambers of a microfabricated fluidic device. The microfabricated fluidic device is then manipulated to vary the solution condition in the chambers, thereby simultaneously providing a large number of crystallization environments. Control over changed solution conditions may result from a variety of techniques, including but not limited to metering volumes of crystallizing agent into the chamber by volume exclusion, by entrapment of volumes of crystallizing agent determined by the dimensions of the microfabricated structure, or by cross-channel injection of sample and crystallizing agent into an array of junctions defined by intersecting orthogonal flow channels.

High throughput screening of crystallization materials

High throughput screening of crystallization of a target material is accomplished by simultaneously introducing a solution of the target material into a plurality of chambers of a microfabricated fluidic device. The microfabricated fluidic device is then manipulated to vary the solution condition in the chambers, thereby simultaneously providing a large number of crystallization environments. Control over changed solution conditions may result from a variety of techniques, including but not limited to metering volumes of crystallizing agent into the chamber by volume exclusion, by entrapment of volumes of crystallizing agent determined by the dimensions of the microfabricated structure, or by cross-channel injection of sample and crystallizing agent into an array of junctions defined by intersecting orthogonal flow channels.

High throughput screening of crystallization of materials

High throughput screening of crystallization of a target material is accomplished by simultaneously introducing a solution of the target material into a plurality of chambers of a microfabricated fluidic device. The microfabricated fluidic device is then manipulated to vary the solution condition in the chambers, thereby simultaneously providing a large number of crystallization environments. Control over changed solution conditions may result from a variety of techniques, including but not limited to metering volumes of crystallizing agent into the chamber by volume exclusion, by entrapment of volumes of crystallizing agent determined by the dimensions of the microfabricated structure, or by cross-channel injection of sample and crystallizing agent into an array of junctions defined by intersecting orthogonal flow channels.

Method and apparatus for the mechanical actuation of valves in fluidic devices

Mechanical actuation of valves in flexible fluidic structures allows for the regulation of fluid flow. In accordance with the disclosure herein, a fluidic structure is provided wherein mechanical actuation is conferred using a pin to actuate a flexible layer to occlude fluid flow in a fluid channel.

Photocurable perfluoropolyethers for use as novel materials in microfluidic devices

A solvent-resistant microfluidio device (MD) is fabricated from a functionalized, photo-curable perfluoropolyether (PFPE). In one embodiment, a polymeric precursor (PP), comprising PFPE, is disposed on a patterned surface (PS) of a substrate (S), having raised protrusions (P). Ultraviolet light (UV) is applied to yield a patterned layer (PL) of photo-cured PFPE having recesses (R) comprising at least one channel (CH). Patterned layer (PL) is removed from patterned surface (PS) of substrate (S) to yield microfluidic device (MD).

Photocurable perfluoropolyethers for use as novel materials in microfluidic devices

The use of a photocurable perfluoropolyether (PFPE) material for fabricating a solvent-resistant PFPE-based microfluidic device, methods of flowing a material and performing a chemical reaction in a solvent-resistant PFPE-based microfluidic device, and the solvent-resistant PFPE-based microfluidic devices themselves are described. In an embodiment, a method is described for preparing a patterned layer of a photocured perfluoropolyether, the method comprising: (a) providing a substrate, wherein the substrate comprises a patterned surface; (b) contacting a perfluoropolvether precursor with the patterned surface of the substrate; and (c) photocuring the perfluoropolyether precursor to form a patterned layer of a photocured perfluoropolyether.

Photocurable perfluoropolyethers for use as novel materials in microfluidic devices