02-05-2013 дата публикации
Номер: US20130107254A1
A surface enhanced Raman spectroscopy (SERS) analytical device includes a substrate having a porous structure, and a plurality of plasmonic nanoparticles embedding in the porous structure and forming a sensing region. A method of detecting a target analyte in a sample includes contacting the sample with the substrate, whereby the target analyte, if present in the sample, is concentrated in the sensing matrix. The substrate may then be analyzed using SERS detection equipment. 1. A surface enhanced Raman spectroscopy (SERS) analytical device , comprising:a substrate having a porous structure;a plurality of plasmonic nanoparticles embedded in said porous structure and forming a sensing region.2. The substrate of claim 1 , wherein said substrate comprises a material selected from the group consisting of cellulose claim 1 , modified cellulose claim 1 , a natural polymer claim 1 , an artificial polymer claim 1 , glass fibers claim 1 , a metal claim 1 , and combinations thereof.3. The substrate of claim 1 , wherein said plurality of plasmonic nanoparticles comprises one or more clusters of nanoparticles.4. The substrate of claim 1 , wherein said plurality of plasmonic nanoparticles comprises individual nanoparticles discretely spaced relative to each other.5. The substrate of claim 1 , wherein said plasmonic nanoparticles are formed from a material selected from the group consisting of silver claim 1 , gold claim 1 , copper claim 1 , platinum claim 1 , and combinations thereof.6. The substrate of claim 1 , wherein said substrate includes at least one of a hydrophilic portion or a hydrophobic portion.7. A method of fabricating a surface enhanced Raman spectroscopy (SERS) device claim 1 , comprising the steps of:providing a substrate having a porous morphology;embedding a plurality of plasmonic nanoparticles in the porous substrate, thereby forming a SERS sensing region.8. The method of claim 7 , comprising the further step of modifying at least a portion of the substrate to ...
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