Поиск патентов

06-12-2012 дата публикации

System and mehtod for measuring glass transition temperature

Номер: US20120307860A1

Автор: James P. Nokes, Rafael J. Zaldivar

Принадлежит: Aerospace Corp

A system and method for measuring a glass transition temperature of a hydrophobic polymer having a surface tagged with an atmospheric plasma.

Подробнее

Номер записи: 1

28-03-2013 дата публикации

System and method for dissolution analysis of drug-eluting medical devices

Номер: US20130074587A1

Автор: Mel Merciadez

Принадлежит: Cordis Corp

This disclosure is directed to systems and methods for holding a medical device such as a stent undergoing dissolution analysis. A clip retains the device in a specific, reproducible orientation and positions it within a sample cell of the dissolution testing apparatus. Preferably, the medical device is positioned away from areas having relatively greater flow turbulence.

Подробнее

Номер записи: 2

06-02-2014 дата публикации

Methods and apparatus to determine diffusion properties of porous structures for drug delivery

Номер: US20140033800A1

Автор: Cary Reich, Kathleen Cogan Farinas, Michael S. Barrett, Randolph E. Campbell, Signe Erikson

Принадлежит: ForSight Vision4 Inc

Disclosed herein are improved therapeutic devices and methods and improved porous structures and measurement apparatus for use with therapeutic devices. In many embodiments, a porous structure is measured based on diffusion of the gas through the porous structure. The gas measurement may comprise an amount of gas measured to determine a resistance of the porous structure to diffusion. The diffusion of the gas through the porous structure can be used to determine release of a therapeutic agent through the porous structure, such that targeted amounts of therapeutic agent can be released for extended times and such that therapeutic device reservoir volume and porous frit structure can be tuned to release the therapeutic agent for an extended time above a target amount for the extended time.

Подробнее

Номер записи: 3

06-01-2022 дата публикации

METHOD AND DEVICE FOR PHYSICOCHEMICAL CHARACTERIZATION OF MATERIALS

Номер: US20220003737A1

Автор: Antikainen Osmo, Ehlers Henrik, Räikkonen Heikki, Svanbäck Sami, Yliruusi Jouko

Принадлежит: The Solubility Company Oy

An analysis method and device including detecting at least one particle of matter in a fluid inside in a reaction chamber and correlating a change in the particle to a physicochemical property of the matter. 1. An analysis device comprisinga reaction chamber;at least one first inlet configured for passing at least one first fluid into the reaction chamber;at least one outlet configured for passing the at least one first fluid outside the reaction chamber;an immobilization zone arranged inside the reaction chamber configured to immobilize at least one particle; anda detection component capable of detecting changes in the at least one particle in the immobilization zone.2. The analysis device of claim 1 , wherein the at least one first inlet is configured for passing at least one second fluid into the reaction chamber claim 1 , the at least one outlet is configured for passing the at least one second fluid outside the reaction chamber and the immobilization zone is configured to immobilize at least one particle in at least one second fluid.3. The analysis device of claim 1 , wherein the detection component comprises a window arranged in a top plate claim 1 , bottom plate or in a wall defining the reaction chamber.4. The analysis device of claim 1 , wherein the detection component is integrated in a wall claim 1 , a top plate or a bottom plate of the device.5. The analysis device of claim 1 , wherein the immobilization zone comprises a permeable or semipermeable layer configured to receive the at least one particle via at least one second fluid.6. The analysis device of claim 1 , wherein the immobilization zone comprises a permeable or semipermeable layer configured to receive the at least one particle.7. A system comprising the analysis device of claim 1 , further comprising a fluid handling device for controlled passing of the at least one fluid through the analysis device claim 1 , the detection component capable of providing data about the at least one particle to ...

Подробнее

Номер записи: 4

05-01-2017 дата публикации

METHOD FOR MEASURING DIFFUSION PERFORMANCE OF ACID DYE IN COLOR PASTE

Номер: US20170003211A1

Автор: Chen Feng, LONG Jiajie

Принадлежит:

The invention provides a method for measuring the diffusion performance of an acid dye in a color paste, comprising preparing a primary paste and placing the primary paste into a transparent cylindrical container; adding a dye to the primary paste formulate a color paste, and flatly and uniformly paving a layer of the color paste on an upper surface of the primary paste; performing constant-temperature treatment at 60-95° C. on the cylindrical container, so that the dye in the color paste on the top of the blank primary paste in the cylindrical container diffuses downwards to the bottom of the cylinder; and sampling the primary paste from a sampling hole, and diluting the sampled primary paste with deionized water. The method of the invention has simple operation steps, reliable and safe experiments, highly stable test data and good reproducibility of results, and high temperature and high pressure are not required herein. 2. The method for measuring the diffusion performance of an acid dye in a color paste as claimed in claim 1 , wherein the paste in the step A is selected from the group consisting of sodium alginate claim 1 , guar gum and carboxymethyl starch and any combination thereof.3. The method for measuring the diffusion performance of an acid dye in a color paste as claimed in claim 1 , wherein the primary paste in the step A contains an additive which is glycerol claim 1 , urea or ammonium sulphate claim 1 , the molar concentration of glycerol being 7.0×10molLto 5.0×10mol L claim 1 , the molar concentration of urea being 4.0×10mol Lto 1.5×10mol L claim 1 , and the molar concentration of ammonium sulphate being 1.0×10mol Lto 3.0×10mol L.4. The method for measuring the diffusion performance of an acid dye in a color paste as claimed in claim 3 , wherein the molar concentration of glycerol is 9.0×10mol Lto 3.0×10mol L claim 3 , the molar concentration of urea is 2.0×10mol Lto 1.0×10mol L claim 3 , and the molar concentration of ammonium sulphate is 0.5×10mol ...

Подробнее

Номер записи: 5

03-02-2022 дата публикации

DISSOLUTION DEVICE

Номер: US20220032283A1

Автор: Boyer Scott, GRILC Blaz, Hubinette Fredrik, MASCHER Erik, Planinsek Odon

Принадлежит: KLARIA PHARMA HOLDING AB

A dissolution device for measuring a dissolution rate of a test sample in a fluid, the device comprising a first cavity and a second cavity, wherein each of the first and second cavities has a fluid inlet for connection to a fluid supply, and wherein the device comprises an opening between the first and second cavities, and the device comprises a sample support configured to position the test sample across the opening. 1. A dissolution device for measuring a dissolution rate of a test sample in a fluid , the device comprising:a first cavity; anda second cavity;wherein each of the first and second cavities has a fluid inlet for connection to a fluid supply; andwherein the device comprises an opening between the first and second cavities, and the device comprises a sample support configured to position the test sample across the opening.2. The device of claim 1 , wherein the sample support comprises a permeable support configured to support the test sample across the opening.3. (canceled)4. The device of claim 1 , further comprising first and second fluid supplies claim 1 , wherein the first and second cavities are in fluid communication respectively with the first and second fluid supplies via the respective fluid inlets claim 1 , and wherein the first fluid supply is at a static pressure claim 1 , measurable at a point within the first cavity and adjacent the test sample claim 1 , that is equal to or higher than a static pressure of the second fluid supply claim 1 , measurable at a point within the second cavity and adjacent the test sample.5. The device of claim 4 , wherein at least one of the first and second fluid supplies is configured to be substantially free of pressure pulsation.6. The device of claim 4 , wherein the first and second fluid supplies are configured to produce a substantially constant relative pressure therebetween.7. The device of claim 4 , wherein the static pressure of at least one of the first and second fluid supplies is provided by a ...

Подробнее

Номер записи: 6

18-01-2018 дата публикации

Method for detecting dissolution rate of preparation containing colloidal bismuth pectin

Номер: US20180017496A1

Автор: Anping LI, Feng CUI, Ping Zhu, Tai Zheng, Yuexia WU, Zhengguo QIN

Принадлежит: Shanxi Zhendong Ante Biopharmaceutical Co Ltd

A method for detecting a dissolution rate of a preparation containing colloidal bismuth pectin includes steps of: according to “ Pharmacopoeia of the People's Republic of China , 2010 Edition, Volume 2, Appendix XC”, dispersing the preparation containing the colloidal bismuth pectin into dissolution medium, and directly obtaining dissolution liquid; adding a protonic acid dissociation agent into the dissolution liquid until a hydrogen ion concentration reaches 0.8-1.2 mol/L; centrifuging for separating a supernatant; coloring the supernatant by adding a chromogen solution of citric acid or ascorbic acid and potassium iodide to obtain a test solution; calculating a dissolution amount, which is accounted by bismuth, of the colloidal bismuth pectin with a spectrophotometry method. The method of the present invention well detects dissolution curves and rates of the colloidal bismuth pectin in the preparation thereof, satisfying quality control requirements.

Подробнее

Номер записи: 7

18-01-2018 дата публикации

Coal-to-coal adhesiveness evaluation method

Номер: US20180017539A1

Автор: Hidekazu Fujimoto, Hiroyuki Sumi, Izumi Shimoyama, Kiyoshi Fukada, Takashi Anyashiki, Tetsuya Yamamoto, Yusuke Dohi

Принадлежит: JFE Steel Corp

In order to evaluate the compatibility of coals used in coke production and to produce cokes with desired strength by blending coals in consideration of the compatibility, the invention provides a technique which evaluates the adhesion strength obtained when two kinds of coals are carbonized based. on properties of the coals. Surface tensions of two kinds of semicokes obtained by heat treating two kinds of coals are measured. Based on the difference between the two measured values of surface tension, the quality of the adhesiveness between the two kinds of coals is evaluated.

Подробнее

Номер записи: 8

24-01-2019 дата публикации

RESONANTLY-DRIVEN DROP CONTACT-LINE MOBILITY MEASUREMENT

Номер: US20190025177A1

Автор: STEEN Paul H., XIA Yi

Принадлежит: CORNELL UNIVERSITY

The present disclosure relates to, inter alia, systems and methods for measuring contact-line mobility of a liquid on a solid substrate. The system includes a motion-generation component, a motion-measurement component, and a computer component. The motion-generation component can include an actuator and a controller, the actuator being adapted to mount a solid substrate and effective to impart periodic forcing to the solid substrate when a test droplet of the liquid is deposited thereon, and the controller being adapted to tune frequency and amplitude of the forcing to induce measurable contact-line displacement of the test droplet on the solid substrate. The motion-measurement component includes an image acquisition device adapted for capturing images of the test droplet. The image acquisition device has requisite spatial and temporal resolution to enable acquisition of image data of the test droplet, the image data including contact-line displacement, contact-line speed, and contact angle at or near contact-line. 1. A system for measuring contact-line mobility of a liquid on a solid substrate , wherein said system comprises: (i) said actuator adapted to mount a solid substrate, and effective to impart periodic forcing to the solid substrate when a test droplet of the liquid is deposited thereon; and', '(ii) said controller is adapted to tune frequency and amplitude of the forcing to induce measurable contact-line displacement of the test droplet on the solid substrate;, '(a) a motion-generation component comprising an actuator and a controller, wherein(b) a motion-measurement component comprising an image acquisition device adapted for capturing images of the test droplet deposited on the solid substrate before, during and/or after the forcing imparted by the actuator, said image acquisition device having requisite spatial and temporal resolution to enable acquisition of image data of the test droplet comprising contact-line displacement, contact-line speed, and ...

Подробнее

Номер записи: 9

23-01-2020 дата публикации

Vitro Method and Apparatus for Analysing the Behaviour of Substances in Simulated Physiological Environment

Номер: US20200025664A1

Автор: JERE Dhananjay Jagdish, Mahler Hanns-Christian, Patel Sulabh

Принадлежит:

The invention refers to an in vitro method and apparatus for analysing the behaviour of substances in simulated physiological environment. The method comprises the steps of providing a first fluid, a gel matrix and a second fluid, separating the first fluid and the gel matrix by at least one first semi-permeable membrane and separating the gel matrix and the second fluid by at least one second semi-permeable membrane. The method further comprises the steps of injecting a substance into the first fluid, letting the substance migrate from the first fluid through the at least one first semi-permeable membrane, through the gel matrix, through the at least one second semi-permeable membrane and into the second fluid, and determining clearance of the substance from the first fluid. 121.-. (canceled)22. An apparatus for analyzing the behaviour of molecules in simulated physiological environment , the apparatus comprisinga first compartment for receiving a first fluid,a second compartment for receiving a gel matrix, anda third compartment for receiving a second fluid; the apparatus further comprisingat least one first semi-permeable membrane, andat least one second semi-permeable membrane, the at least one second semi-permeable membrane being arranged at a distance from the at least one first semi-permeable membrane, whereinthe at least one first semi-permeable membrane is arranged between the first compartment and the second compartment, and wherein the at least one second semi-permeable membrane is arranged between the second compartment and the third compartment.23. The apparatus according to claim 22 , wherein the first compartment claim 22 , the second compartment and the third compartment are arranged in a row claim 22 , and wherein the at least one first semi-permeable membrane and the at least one second semi-permeable membrane are arranged substantially vertically between the respective compartments.24. The apparatus according to claim 22 , further comprising ...

Подробнее

Номер записи: 10

28-01-2021 дата публикации

Experimental Device for Measuring Diffusion Coefficient of Natural Gas

Номер: US20210025801A1

Автор: Jiayi Zhang, Shuyong Hu, Tingting Qiu

Принадлежит: SOUTHWEST PETROLEUM UNIVERSITY

The present invention discloses a new experimental device for measuring a diffusion coefficient of natural gas, mainly including a new core holder, a differential pressure sensor, pressure gauges, multiport valves, a confining pressure pump, a vacuum pump, a hydrocarbon gas source, a nitrogen gas source, a gas chromatograph, an intermediate container, sample chambers, a pressure stabilizing device, and pressure-sensitive alarm devices. A rubber sleeve of the new core holder can prevent a core from being stuck in the holder during core replacement due to an improper operation. The configured pressure stabilizing device is connected to the sample chambers, to ensure stable internal pressure in the chambers after sampling. In this way, one experimental variable is omitted, and an experimental result is more accurate and reliable. If gas leakage occurs. A sensor device can sense the gas leakage in time and sends an alarm to a mobile device of an experimenter.

Подробнее

Номер записи: 11

04-02-2016 дата публикации

PORTABLE SENSORS FOR DETERMINATION OF LIQUID SURFACE TENSION, AND METHODS OF USES THEREOF

Номер: US20160033383A1

Автор: FALDE Eric, Grinstaff Mark W., Yohe Stefan

Принадлежит:

The present invention relates to the measurement of liquid surface tension using a small, portable sensor. More specifically, the present invention relates to a sensor on which a droplet of the sample liquid is placed and quickly either wets and changes color or remains non-wetted for several minutes. The detection range of this type of sensor is tunable to surface tensions useful for detecting surfactant levels in water, biological liquids, and other liquids, making it useful for a variety of medical, veterinary, home-care, environmental, and global health applications. 1. A method of determining surface tension of a fluid sample comprising:a. contacting the fluid sample with a selectively wetting layer of a surface tension sensor, wherein the surface tension sensor comprises the selectively wetting layer and an indicator layer, the selectively wetting layer comprising a roughened and/or porous structure tuned to a pre-determined critical wetting surface tension (CWST), and the indicator layer comprising a hydrophilic material and a detectable agent, wherein the detectable agent generates a detectable signal upon wetting of the indicator layer;b. detecting a detectable signal from the indicator layer; and 'determining surface tension of the fluid sample to be at or above the pre-determined CWST if a detectable signal from the indicator layer is absent.', 'c. determining surface tension of the fluid sample to be below the pre-determined CWST if a detectable signal from the indicator layer is present; or'}2. The method of claim 1 , wherein the selectively wetting layer comprises microfibers.3. The method of claim 2 , wherein the microfibers have a diameter of about 1 μm to about 10 μm.4. The method of claim 1 , wherein the pre-determined CWST is characterized by a non-wetted or partially wetted state to a wetted state within a range of about 1-2 mN/m claim 1 , 2-3 mN/m claim 1 , or 3-4 mN/m.5. The method of claim 1 , wherein the predetermined CWST is between 25 and ...

Подробнее

Номер записи: 12

05-02-2015 дата публикации

Method and Device for Determining Solid Particle Surface Energy

Номер: US20150033833A1

Автор: Bikkina Prem Kumar, Gomez Luis Eduardo, Kouba Gene Edward, Mohan Ram S., Shoham Ovadia, Subramani Hariprasad Janakiram

Принадлежит:

A method of determining solid particle surface energy includes placing solid particles in a container made of a very high surface energy material and pouring a liquid into the container. The method further includes tilting the container to drain out from the container a first subset of the solid particles floating at a top surface of the liquid and tilting the container to move the liquid away from a second subset of the solid particles that are below the top surface. The method also includes tilting the container to move the liquid back toward the second subset of the solid particles such that at least a portion of the second subset of particles floats at the top surface of the liquid and tilting the container to drain out from the container the portion of the second subset of the solid particles now floating at the top surface of the liquid. 1. A method of determining solid particle surface energy , the method comprising:placing solid particles in a container made of a very high surface energy material;pouring a liquid into the container;tilting the container to drain out from the container a first subset of the solid particles floating at a top surface of the liquid;tilting the container to move the liquid away from a second subset of the solid particles that are below the top surface;tilting the container to move the liquid back toward the second subset of the solid particles such that at least a portion of the second subset of particles floats at the top surface of the liquid; andtilting the container to drain out from the container the portion of the second subset of the solid particles now floating at the top surface of the liquid.2. The method of claim 1 , further comprising repeating the steps of tilting the container to move the liquid away from the second subset of the solid particles claim 1 , tilting the container to move the liquid back toward the second subset of solid particles claim 1 , and tilting the container to drain out from the container the ...

Подробнее

Номер записи: 13

04-02-2021 дата публикации

Apparatus buffer and method for ph control

Номер: US20210033588A1

Автор: Andrew Curl, Dean Fitzgerald, Fang Liu

Принадлежит: University of Hertfordshire

An apparatus, buffer solutions and a method are provided for pH control of in vitro dissolution tests used to monitor the drug release rate from solid unit dosage forms which are used to predict their in vivo effects or for quality control purposes. A method of preparing a continuous condition and a clear bicarbonate ion based solution for in vitro dissolution testing of pharmaceutical products is also provided. An enclosure device is also provided for use in the provision of pH control and stabilization to a bicarbonate based solution used in the in vitro dissolution testing of pharmaceutical products.

Подробнее

Номер записи: 14

24-02-2022 дата публикации

MEASURING DEVICE FOR MEASURING AN INTENSIVE MEASURAND

Номер: US20220054018A1

Автор: HOSS Michael, WIORA Georg

Принадлежит: Courage + Khazaka Electronic GmbH

In a measuring device for measuring an intensive measurand, including at least one measuring chamber having at least one opening, the opening being placeable on the body to be examined. At least three sensors for measuring the intensive measurand are arranged in the measuring chamber, the sensors being arranged at different distances from the body to be examined during measurement. An evaluation device being provided which receives the values measured by the sensors and determines a total value for the intensive measured variable from the at least three measured values as well as a substance or energy diffusion rate. 127-. (canceled)28. A measuring device for measuring an intensive measurand , in particular the concentration of a substance emitted by a body by diffusion or the temperature , comprising at least one measuring chamber having at least one opening , the opening being placeable on the body to be examined ,wherein at least three sensors for measuring the intensive measurand are arranged in the measuring chamber, the sensors being arranged at different distances from the body to be examined during measurement,wherein an evaluating device is provided that receives the values measured by the sensors and determines a total value for the intensive measurand from the at least three measured values.29. The measuring device according to claim 28 , wherein the measuring chamber comprises at least two openings.30. The measuring device according to claim 28 , wherein a calculation rule is stored in the evaluating device claim 28 , on the basis of which the evaluating device determines the total value.31. The measuring device according to claim 30 , wherein the calculation rule stored in the evaluating device weights the values measured by the sensors differently to determine the total value for the intensive measurand.32. The measuring device according to claim 30 , wherein the calculation rule stored in the evaluating device uses a robust estimator when determining ...

Подробнее

Номер записи: 15

24-02-2022 дата публикации

Diffusion Cell Clamping and Assembly Tools

Номер: US20220057313A1

Автор: Huang Joseph Zhili, Wen Ping

Принадлежит:

A diffusion/permeation cell, commonly referred to as a Franz cell, is provided for topical or transdermal drug delivery research and development in the pharmaceutical industry. The cell comprises a receptor container, a donor chamber, a quick clamping apparatus, and/or an assembly tool. Systems and methods provide a cost-effective diffusion cell, especially for use with an automatic diffusion release testing system. 2. The diffusion cell of claim 1 , wherein the clamping nut has a U-shape bottom plate and the threads on its upper body.3. The clamping nut of claim 1 , wherein the preferred material for the clamping nut is plastics and made by 3D printing or injection model fabrication.4. The clamping nut of claim 1 , wherein the donor cap is made from inert material comprising at least one of glass and teflon.5. The diffusion cell of claim 1 , wherein the pressing screw has an opening at its center and the threads on its body claim 1 , wherein a preferred material is plastics and made by 3D printing or injection model fabrication.6. A diffusion cell assembly tool claim 1 , comprising:a body;its top surface;a recess;raised pallets; andbaffle plates.7. The diffusion cell assembly tool of claim 6 , wherein the top surface has a contour profile of the U-shape bottom plate of the clamping nut.8. The diffusion cell assembly tool of claim 6 , wherein the recess has a contour profile of the receptor container of the diffusion cell.9. The diffusion cell assembly tool of claim 6 , wherein a height of the raised pallets is equal to a height of the U-shape bottom plate of the clamping nut.10. The diffusion cell assembly tool of claim 6 , wherein the baffle plates are higher than the thickness of the annular flange of the receptor container.11. The diffusion cell assembly tool of claim 6 , wherein the body of the tool is made from 3D printing or plastic injection model.12. A method of assembling a diffusion cell claim 6 , comprising:placing a donor plate with a center opening ...

Подробнее

Номер записи: 16

24-02-2022 дата публикации

ANALYTICAL METHOD FOR DETERMINATION OF IN VITRO DRUG RELEASE PROFILE FROM MICRONEEDLE PATCHES

Номер: US20220057377A1

Автор: Ameri Mahmoud, He Aihua, Lewis Hayley

Принадлежит:

The present disclosure relates to a novel in vitro dissolution method to assess the release of a bioactive agent from an intracutaneous microneedle system wherein the bioactive agent is coated on or integral to the microneedles. The present disclosure further relates to a novel sample holder clip assembly specially adapted for use with microneedle arrays and patches. 1. A method for determining the in vitro dissolution profile of a bioactive agent from a microneedle patch , comprising the steps of:a. providing a microneedle patch comprising a bioactive agent;b. affixing the patch to an outer surface of a sample holder wherein the microneedles are oriented outward from the outer surface;c. applying a membrane over the microneedles and the patch;d. immersing the sample holder having the patch and membrane in a dissolution medium;e. taking at least 2 samples of the dissolution medium at different time points;f. determining the concentration of the bioactive agent in the samples; andg. calculating the rate of dissolution of the bioactive agent from the patch.2. The method of further comprising attaching a clip over the membrane and sample holder.3. The method of wherein the clip has an opening.4. The method of wherein the opening is a shape selected from the group consisting of rectangular claim 3 , square claim 3 , oblong claim 3 , circular claim 3 , parallelogram claim 3 , pentagon claim 3 , octagon claim 3 , hexagon claim 3 , rhombus claim 3 , oval claim 3 , and triangular.5. The method of wherein the opening is a size of about 10 cm claim 3 , or 9 cm claim 3 , or 8 cm claim 3 , or 7 cm claim 3 , or 6 cm claim 3 , or 5 cm claim 3 , or 4 cm claim 3 , or 3 cm claim 3 , or 2 cm claim 3 , or 1 cm.6. The method of wherein the dissolution medium has a volume of about 50 mL to about 200 mL.7. The method of wherein the dissolution medium has a volume of about 900 mL.8. The method of wherein the dissolution medium has a temperature of about 32 degrees.9. The method of wherein ...

Подробнее

Номер записи: 17

15-02-2018 дата публикации

APPARATUS AND METHODS FOR DETERMINING SURFACE WETTING OF MATERIAL UNDER SUBTERRANEAN WELLBORE CONDITIONS

Номер: US20180045633A1

Автор: Bardapurkar Sameer, Gajji Bhargav, Palla Venkata Gopala Rao, PINDIPROLU Sairam KS

Принадлежит:

Methods and apparatuses for determining surface wetting of metallic materials at downhole wellbore condition with fixed or changing well fluids are disclosed. In general, the methods according to the disclosure include carrying out an electrical impedance spectroscopy (“EIS”) for a system simulating downhole conditions for the wetting of a surface by simultaneously dynamically moving electrodes exposed to the well fluid while measuring the changes in electrical characteristics between the electrodes. 1. A method comprising the steps of:a. providing a first and second electrodes each having a surface thereon;b. wetting the surfaces on the first and second electrodes with a first fluid;c. immersing the surfaces on the first and second electrodes in a second fluid;d. moving the first and second electrodes in the second fluid; ande. at least once during or after applying the moving step, making an electrical impedance spectroscopy measurement between the first and second electrodes while maintaining the electrodes electrically insulated from each other and immersed in the second fluid.2. The method according to claim 1 , wherein the moving step creates shear between the surfaces and the second fluid.3. The method according to claim 1 , wherein the providing claim 1 , wetting claim 1 , immersing claim 1 , moving a measurement steps are performed at one or more of temperatures elevated above atmospheric temperature and pressures elevated above atmospheric pressure.4. The method according to claim 1 , wherein the moving step comprises rotating the first and second electrodes in the second fluid.5. The method according to claim 1 , additionally comprising the steps of: before the moving step claim 1 , making a first electrical impedance spectroscopy measurement between the first and second electrode; during or after the moving step claim 1 , making a second electrical impedance spectroscopy measurement between the first and second electrode; comparing the first electrical ...

Подробнее

Номер записи: 18

14-02-2019 дата публикации

SYSTEM AND METHOD FOR AUTOMATICALLY MIXING SOLUTIONS

Номер: US20190049350A1

Автор: Colin Bruno, MILTCHEFF Audrey

Принадлежит: BIOMERIEUX

A system for mixing solutions includes: a first container and at least one second container capable of containing solutions, each second container being capable of entirely containing the first container; means for displacing the first container and/or each second container capable of entirely immersing the first container in each second container; and rotational drive means for the first container so as to mix the solutions present in the first and second containers when the first container is entirely immersed in the solution present in the second container. 1. A system for mixing solutions comprising:a first container and at least one second container capable of containing solutions, each second container being capable of entirely containing the first container;means for displacing the first container and/or each second container capable of entirely immersing the first container in each second container; androtational drive means for the first container so as to mix the solutions present in the first and second containers when the first container is entirely immersed in the solution present in the second containerin which the first container has a solid cylindrical and/or conical internal wall.2. The system as claimed in claim 1 , in which the first container has an internal volume for filling with solution of between 1 milliliter and 5 milliliters.3. The system as claimed in claim 1 , in which the first container has:an internal volume for introducing the solution of between 1 milliliter and 2 milliliters;{'sup': 2', '2, 'an opening for fluid passage of an area of between 57 mmand 133 mm.'}4. The system as claimed in claim 1 , comprising a plurality of second containers claim 1 , the displacement means being capable of immersing the first container in succession in the second containers.5. The system as claimed in claim 1 , comprising means for filling the first container with a solution for dilution and means for filling each second container with a dilution ...

Подробнее

Номер записи: 19

21-02-2019 дата публикации

Methods of diagnosing diseases of mucosal surfaces

Номер: US20190053702A1

Автор: Bernardo YAÑEZ-SOTO, Christopher J. Murphy, Nicolas L. ABBOTT, Vijay Krishna RAGHUNATHAN

Принадлежит: UNIVERSITY OF CALIFORNIA, WISCONSIN ALUMNI RESEARCH FOUNDATION

Provided are methods for assessment of surface rugosity of a layer of live cells using tools that determine contact angle and contact angle hysteresis.

Подробнее

Номер записи: 20

10-03-2022 дата публикации

GREASE EVALUATION

Номер: US20220074916A1

Автор: Khonsari Michael M., Koottaparambil Lijesh

Принадлежит:

Methods of evaluating viscous compositions are disclosed. The methods may be used to evaluate degradation levels of lubricants including grease. The methods may include preparing a surface for testing by leveling and flattening a viscous composition, placing a drop of a liquid on the flattened leveled surface, evaluating the observed contact angle between the drop and the surface, and then comparing the observed contact angle to a reference contact angle. 1. A method of evaluating lubricant comprising:a. acquiring a sample of a mechanically used grease from a mechanical device;{'claim-text': ['i. orienting a portion of the sample to level and', 'ii. flattening the portion of the sample;'], '#text': 'b. preparing a grease surface for testing by'}c. placing a drop of a liquid on the grease surface;d. evaluating an observed contact angle between the drop and the grease surface; ande. comparing the observed contact angle to a reference contact angle;f. wherein the mechanically used grease is degraded as compared to a pristine grease of the same type.2. The method of wherein the mechanically used grease has experienced bleed off as compared to the pristine grease of the same type.3. The method of wherein the mechanically used grease has experienced oxidation as compared to the pristine grease of the same type.4. The method of wherein the mechanically used grease has experienced mechanical degradation as compared to the pristine grease of the same type.5. The method of wherein the mechanically used grease has experienced contamination as compared to the pristine grease of the same type.6. The method of wherein the mechanically used grease has experienced water contamination as compared to the pristine grease of the same type.7. The method of wherein the observed contact angle correlates with the kinematic viscosity of the mechanically used grease across varying degradation levels for a degradation type wherein the degradation type is selected from bleed off claim 1 , ...

Подробнее

Номер записи: 21

01-03-2018 дата публикации

Alkylaromatic Sulfonate Compositions From Mixed Hydrocarbons

Номер: US20180057451A1

Автор: BIELENBERG James R., Gooding Beatrice M., Owens Tracie L., Reiner Virginia M., Zhang Jingwen, ZHAO Mosha H.

Принадлежит:

Provided herein are various methods for forming alkylaromatic sulfonate compositions and blended alkylaromatic sulfonate compositions, and such compositions themselves. The methods of various embodiments include obtaining a C-Chydrocarbon mixture, optionally treating the mixture to concentrate the mixture in sulfonatable aromatics, and sulfonating the mixture to form the alkylaromatic sulfonates. The mixture or treated mixture may be blended with linear alkyl benzene (LAB) compositions and sulfonated, and/or the alkylaryl sulfonates may be blended with linear alkylbenzene sulfonate (LAS) compositions, to form the blended alkylaromatic sulfonates of some embodiments. These compositions and processes for making them may be tailored to serve a variety of end uses, such as detergents in cleaning solutions or for enhanced oil recovery operations, and/or as low foaming and/or hydrotropic additives in detergent formulations, and the like. 1. A process comprising:{'sub': 7', '30, 'claim-text': wherein the hydrocarbon mixture comprises 5-40 wt % sulfonatable aromatics comprising: (i) mono-alkyl benzenes; (ii) multi-alkyl benzenes in which any two adjacent alkyl substitutions on the benzene may be joined to form a non-aromatic ring fused to the benzene, provided that either or both of the benzene and the fused non-aromatic ring is further alkyl-substituted; and, optionally, (iii) alkyl-substituted polycyclic aromatics;', 'further wherein the hydrocarbon mixture comprises 1.75-30 wt % of the mono-alkyl benzenes, 0.25-30 wt % of the multi-alkyl benzenes, and 0-20 wt % of the alkyl-substituted polycyclic aromatics, such wt % s based on the total mass of the hydrocarbon mixture;, '(a) obtaining a hydrocarbon mixture comprising at least 90 wt % C-Chydrocarbons;'} wherein the treating comprises 1, 2, 3, 4, or 5 solvent extractions; and', 'further wherein the precursor alkylaromatic composition comprises 15-35 wt % mono-alkyl benzenes, 15-30 wt % multi-alkyl benzenes; and 0-25 wt % ...

Подробнее

Номер записи: 22

01-03-2018 дата публикации

Alkylaromatic Sulfonate Compositions From Mixed Hydrocarbons

Номер: US20180057452A1

Автор: Jingwen Zhang, Mosha H. ZHAO, Tracie L. Owens, Virginia M. REINER

Принадлежит: ExxonMobil Chemical Patents Inc

Provided herein are various methods for forming alkylaromatic sulfonate compositions and blended alkylaromatic sulfonate compositions, and such compositions themselves. The methods of various embodiments include obtaining a C 8 -C 30 hydrocarbon mixture, optionally treating the mixture to concentrate the mixture in sulfonatable aromatics, and sulfonating the mixture to form the alkylaromatic sulfonates. The mixture or treated mixture may be blended with linear alkyl benzene (LAB) compositions and sulfonated, and/or the alkylaryl sulfonates may be blended with linear alkylbenzene sulfonate (LAS) compositions, to form the blended alkylaromatic sulfonates of some embodiments. These compositions and processes for making them may be tailored to serve a variety of end uses, such as detergents in cleaning solutions or for enhanced oil recovery operations, and/or as low foaming and/or hydrotropic additives in detergent formulations, and the like.

Подробнее

Номер записи: 23

01-03-2018 дата публикации

Alkylaromatic Sulfonate Compositions From Mixed Hydrocarbons

Номер: US20180057453A1

Автор: Owens Tracie L., Reiner Virginia M., Zhang Jingwen, ZHAO Mosha H.

Принадлежит:

Provided herein are various methods for forming alkylaromatic sulfonate compositions and blended alkylaromatic sulfonate compositions, and such compositions themselves. The methods of various embodiments include obtaining a C-Chydrocarbon mixture, optionally treating the mixture to concentrate the mixture in sulfonatable aromatics, and sulfonating the mixture to form the alkylaromatic sulfonates. The mixture or treated mixture may be blended with linear alkyl benzene (LAB) compositions and sulfonated, and/or the alkylaryl sulfonates may be blended with linear alkylbenzene sulfonate (LAS) compositions, to form the blended alkylaromatic sulfonates of some embodiments. These compositions and processes for making them may be tailored to serve a variety of end uses, such as detergents in cleaning solutions or for enhanced oil recovery operations, and/or as low foaming and/or hydrotropic additives in detergent formulations, and the like. 3. The process of claim 1 , wherein the hydrocarbon mixture comprises at least 95 wt % of the alkylated naphthalenes claim 1 , and the blended alkylaromatic precursor comprises (i) from 2 to 60 wt % of the alkylated naphthalenes claim 1 , and (ii) from 40 to 98 wt % of the LAB composition.4. The process of claim 3 , wherein the blended alkylaromatic precursor comprises (i) from 2 to 25 wt % of the alkylated naphthalenes claim 3 , and (ii) from 75 to 98 wt % of the LAB composition.5. The process of claim 2 , wherein each of the alkylated naphthalenes is a tri-alkyl-substituted naphthalene claim 2 , such that one of R-Ris H.6. The process of claim 4 , wherein Ris H claim 4 , Ris C-Calkyl claim 4 , and Rand Rare each C-Calkyl.7. The process of claim 5 , wherein each of the alkylated naphthalenes is 6 claim 5 ,7-dimethyl-1-(4-methylpentyl)-Naphthalene.8. The process of claim 1 , wherein the hydrocarbon mixture comprises at least 95 wt % of the di-alkylbenzenes claim 1 , and the blended alkylaromatic precursor comprises (i) from 2 to 60 wt % ...

Подробнее

Номер записи: 24

04-03-2021 дата публикации

MEASURING DEVICE AND METHOD OF PHYSICAL PROPERTY MEASURING

Номер: US20210060637A1

Автор: CHIANG Tsung-Hsuan, CHUANG Tsung-Han, CHUNG Chih-Ang, HO JENG-RONG, Jang Jason Shian-Ching, LEE Ya-Huan, YEN Chih-Shan

Принадлежит:

A measuring device includes a furnace, a draining vessel, a loader and a computing system for physical properties. The draining vessel with molten metal fluid is in the furnace. The loader accumulates the molten metal fluid from the draining vessel. The computing system includes a recording unit, transform unit, computing unit and processor. The recording unit records the vessel information. By the assumed physical parameters and the vessel information, the transform unit transforms a weight of the molten metal fluid in the loader into a first length criterion, and the computing unit simulates the flowing of the molten metal fluid to have a second length criterion. The processor minimizes the difference of the first and the second length criterion by changing the assumed physical parameters. The physical properties of the molten metal fluid are determined when the difference is minimized. 1. A measuring device for measuring physical properties of a molten metal fluid comprising:a furnace having a chamber;a draining vessel located in the chamber and having an opening, wherein the draining vessel is configured to accommodate the molten metal fluid;a loader aligned with the opening to accumulate the molten metal fluid from the draining vessel during a time period; and a recording unit recording a vessel information of the draining vessel;', 'a transform unit configured to transform a weight of the molten metal fluid accumulated in the loader during the time period into a first length criterion;', 'a computing unit configured to simulate flowing of the molten metal fluid to have a second length criterion by assumed physical parameters and the vessel information; and', 'a processor configured to minimize a difference function of the first and the second length criterions by changing the assumed physical parameters, wherein current physical parameters of the assumed physical parameters are determined as the physical properties of the molten metal fluid when the difference ...

Подробнее

Номер записи: 25

05-03-2015 дата публикации

Modeling Fluid Displacement in a Well System Environment

Номер: US20150066457A1

Автор: Avi LIN, Hongfei Wu, Srinath MADASU

Принадлежит: Halliburton Energy Services Inc

In some aspects, a one-dimensional flow model is generated. The one-dimensional flow model can represent flow of a first fluid and a second fluid in a flow path in a well system environment. The one-dimensional flow model comprises an effective diffusion coefficient model for a composite fluid volume comprising the first and second fluids. The effective diffusion coefficient model calculates an effective diffusion coefficient for the composite fluid volume based on a difference between the respective densities and viscosities of the first fluid and the second fluid.

Подробнее

Номер записи: 26

12-03-2015 дата публикации

FLUID MECHANICAL PROPERTY MEASUREMENT METHOD AND MEASUREMENT DEVICE

Номер: US20150068290A1

Автор: Ishiwata Tomoki, Sakai Keiji

Принадлежит: THE FOUNDATION FOR THE PROMOTION OF INDUSTRIAL SCIENCE

An object is to measure a mechanical property of a fluid at a temporal resolution of at least 100 [μs]. Therefore, a method comprising: causing a droplet to fly by ejecting a fluid to be measured from a nozzle as the droplet ; generating an electric field in a space around a flight path of the droplet by applying a voltage to an electrode arranged in the vicinity of the flight path ; deforming the droplet in a way of contactless deformation with a dielectric force induced by the electric field; and measuring a mechanical property of the fluid based on temporal variation of deformation state of the droplet after deforming the droplet 1. A fluid mechanical property measurement method , the method comprising:causing a droplet to fly by ejecting a fluid to be measured from a nozzle as the droplet;generating an electric field in a space around a flight path of the droplet by applying a voltage to an electrode arranged in the vicinity of the flight path;deforming the droplet in a way of contactless deformation with a dielectric force induced by the electric field; andmeasuring a mechanical property of the fluid based on temporal variation of deformation state of the droplet after deforming the droplet.2. The fluid mechanical property measurement method according to claim 1 , wherein the mechanical property of the fluid is measured with varying duration claim 1 , the duration from ejection of the fluid as the droplet to action of the dielectric force induced by the electric field on the droplet.3. The fluid mechanical property measurement method according to claim 1 , wherein the mechanical property of the fluid is surface tension and/or viscosity.4. The fluid mechanical property measurement method according to claim 1 , wherein the temporal variation of the deformation state is oscillation of deformation of the droplet claim 1 , the oscillation is generated by the surface tension acting as restoring force.5. The fluid mechanical property measurement method according to ...

Подробнее

Номер записи: 27

12-03-2015 дата публикации

Method of evaluating wetting characteristic of object

Номер: US20150072370A1

Автор: Makoto Kaneko, Makoto Kondo, Masayuki Yamato, Nobuyuki Tanaka, Ryohei Uchida, Teruo Okano

Принадлежит: TOKYO WOMENS MEDICAL UNIVERSITY

Provided is a means for evaluating the wetting characteristic of an object such as a cell sheet and a culture dish in a non-contact fashion. The wetting characteristic of an object is evaluated by a method comprising the steps of: (1) removing a liquid by jetting a gas at a surface of the object covered with the liquid, (2) measuring a dimension of a region in which the liquid is removed after the completion of the gas jetting and (3) evaluating the wetting characteristic of the object using the measured dimension as an index.

Подробнее

Номер записи: 28

27-02-2020 дата публикации

DIFFUSION CELLS AND RELATED METHODS

Номер: US20200064247A9

Автор: Dash Alekha, Munt Daniel

Принадлежит:

A method of performing a diffusion test includes clamping a membrane to a body such that a first surface of the membrane is in fluid communication with an interior chamber of the body and a second surface of the membrane is exposed to ambient air, flowing a substance through the ambient air such that at least a portion of the substance lands on the second surface while the membrane is vertically oriented, and determining a concentration of the substance in the interior chamber after some of the substance has diffused through the membrane. 1. A method of performing a diffusion test , comprising:clamping a membrane to a body such that a first surface of the membrane is in fluid communication with an interior chamber of the body and a second surface of the membrane is exposed to ambient air;flowing a substance through the ambient air such that at least a portion of the substance lands on the second surface while the membrane is vertically oriented; anddetermining a concentration of the substance in the interior chamber after some of the substance has diffused through the membrane.2. The method of claim 1 , further comprising preventing the substance from pooling on the membrane.3. The method of claim 1 , further comprising arranging the body in a horizontal orientation prior to flowing the substance through ambient air.4. The method of claim 1 , further comprising assembling a splash guard with the body to prevent an airborne flow of the substance from contacting the body.5. The method of claim 1 , wherein clamping the membrane to the body comprises providing an air-solid interface.6. The method of claim 1 , wherein flowing the substance through the ambient air comprises evenly distributing the substance across the second surface of the membrane.7. The method of claim 1 , further comprising distributing a volume of about 2 μL/cmto about 20 μL/cmof the substance across the second surface of the membrane.8. The method of claim 1 , further comprising flowing a heat ...

Подробнее

Номер записи: 29

08-03-2018 дата публикации

Multicomponent model parameterisation

Номер: US20180067901A1

Автор: Karl Hampton, Oksana Iryna LESZCZYSZYN, Rachel BOTT, Seyi LATUNDE-DADA

Принадлежит: Malvern Instruments Ltd

A method of estimating a parameter for fitting a multi-component Taylorgram model to Taylorgram data g(t) is disclosed. The data comprises a multi-component Taylorgram peak or front at t=t r . The method comprises: evaluating a value of an integration or differential of the data; determining the parameter, based on an analytical expression that includes the value of the integral or differential of the data, the parameter corresponding with a physical property of a sample from which the Taylorgram data was obtained.

Подробнее

Номер записи: 30

09-03-2017 дата публикации

INTERFACIAL TENSION DETERMINATION

Номер: US20170067810A1

Автор: ABDALLAH WAEL, Fedorov Maxim, Ligneul Patrice, STUKAN MIKHAIL

Принадлежит:

Interfacial tension determination is provided. In one possible implementation, temperature information associated with a plurality of points in two fluids is accessed after the fluids have been subjected to a temperature gradient. The temperature information is then analyzed to locate a thermal jump which can be used to determine an interfacial tension between the two fluids. In another possible implementation, a test chamber for determining an interfacial tension between several fluids includes a cell configured to house the fluids. The cell is configured to hinder leakage of energy from the cell. The test chamber also has a gradient apparatus configured to maintain a temperature gradient across the fluids and a plurality of sensors configured to measure temperatures at various locations in the fluids. 1. A method of determining interfacial tension between two fluids comprising:accessing temperature information associated with a plurality of points in the two fluids, wherein the two fluids are subjected to a temperature gradient;analyzing the temperature information to locate a thermal jump; andutilizing the thermal jump to determine the interfacial tension between the two fluids.2. The method of claim 1 , wherein accessing temperature information associated with a plurality of points in the two fluids includes receiving temperature information from a plurality of sensors in physical contact with the two fluids.3. The method of claim 2 , wherein receiving temperature information from a plurality of sensors in physical contact with the two fluids includes receiving temperature from a plurality of sensors set apart from one another at a distance at least 10 times a thickness of a largest sensor in the plurality of sensors.4. The method of claim 1 , wherein accessing temperature information associated with a plurality of points in the two fluids includes receiving temperature information from a plurality of indirect sensors remote from the two fluids.5. The method of ...

Подробнее

Номер записи: 31

05-06-2014 дата публикации

Validation techniques for fluid delivery systems

Номер: US20140154671A1

Автор: Patrice Marchildon, Robert C. Williams, JR.

Принадлежит: BRACCO IMAGING SPA

A fluid delivery system may include a container that houses a medical fluid, a fluid pressurizing unit, and a fluid transfer set that transfers the medical fluid from the container to the fluid pressurizing unit. To validate the integrity and sterility of the fluid delivery system, the system may undergo testing protocols to evaluate the susceptibility of the system to pathogenic ingress, chemical degradation, and/or fluid cross-contamination between patient fluid delivery procedures. The testing protocols may help ensure that delivery system components used during multiple different fluid delivery procedures perform as well as if the components were replaced after each fluid delivery procedure.

Подробнее

Номер записи: 32

21-03-2019 дата публикации

METHOD AND APPARATUS FOR DETERMINING DIFFUSION PROPERTIES OF A SAMPLE

Номер: US20190086313A1

Автор: Goodall David, LATUNDE-DADA Seyi, LESZCZYSZYN Oksana

Принадлежит: Malvern Panalytical Limited

This application discloses a method of using an apparatus comprising a processor to determine a diffusion coefficient (D) of a solute in a solution flowing in a capillary. The method includes obtaining a first signal comprising a plurality of measurements of solute concentration measured at a first measurement location corresponding with a first mean measurement time that is before a full dispersion condition is met; obtaining a second signal comprising a plurality of measurements of solute concentration measured at a second measurement location corresponding with a second mean measurement time that is after the first mean measurement time and before a full dispersion condition is met; calculating an actual front height ratio; a convection front height ratio; and a proportion of the solute that dispersed between the first mean measurement time and the second mean measurement time. 1. An apparatus comprising a processor for determining a diffusion coefficient or hydrodynamic radius of a solute in a solution flowing in a capillary , the apparatus configured to:obtain a first signal, the first signal being proportional to the concentration of molecules in each cross-section of flow past a concentration detector and corresponding to a temporally-resolved distribution of molecular concentration, the first signal comprising a plurality of measurements of solute concentration measured at a first measurement location corresponding with a first mean measurement time that is before a full dispersion condition is met;obtain a second signal, the second signal being proportional to the concentration of molecules in each cross-section of flow past a concentration detector and corresponding to a temporally-resolved distribution of molecular concentration, the second signal comprising a plurality of measurements of solute concentration measured at a second measurement location corresponding with a second mean measurement time that is after the first mean measurement time and before ...

Подробнее

Номер записи: 33

05-05-2022 дата публикации

NATURAL GAS DIFFUSION COEFFICIENT MEASUREMENT AUXILIARY DEVICE BASED ON HAND-OPERATED LIFTING DEVICE

Номер: US20220136948A1

Автор: Guo Xueqiang, Hu Shuyong, Qiu Tingting, SONG NANA, Tang Huiying, WANG Xindong, ZHANG Liehui, ZHAO YULONG

Принадлежит:

The invention discloses a natural gas diffusion coefficient measurement auxiliary device based on a hand-operated lifting device, comprising a core chamber, a bracket, a core preservation device, and a hand-operated lifting device; the left side of the core chamber is connected with a methane measuring chamber, and the right side of the core chamber is connected with a nitrogen measuring chamber; a rotatable bracket is installed on the lower left side of the core chamber, and the lower right side of the core chamber is connected with the hand-operated lifting device; the core chamber is rotated by the hand-operated lifting device with the support as the center; a horizontal platform at the lower part of the core chamber is provided with a revolving door that can accommodate the left end of the core chamber; a core preservation device is installed at the lower part of the revolving door. The invention has a simple structure, which greatly reduces the time required to load the core during natural gas diffusion coefficient measurement, and can effectively prevent the core from breaking and the rubber sleeve from being damaged.

Подробнее

Номер записи: 34

01-04-2021 дата публикации

Surface Analysis Tools for Process Control of Laser Treatment of Composites

Номер: US20210096051A1

Автор: Eileen O. Kutscha, Kay Youngdahl Blohowiak

Принадлежит: Boeing Co

Aspects of the present disclosure are directed methods and systems pertaining to the use of at least one methodology or technique for the purpose of at least one of either: 1) determining that a desired and predetermined level or “degree” of surface treatment of a composite substrate surface has or has not been conducted (e.g., laser treatment of a composite substrate surface); and 2) that a composite substrate surface has been laser treated.

Подробнее

Номер записи: 35

01-04-2021 дата публикации

METHOD FOR DETERMINING RELEASE RATES OF ACTIVE PRINCIPLE INGREDIENTS FROM AT LEAST ONE SEMISOLID FORM

Номер: US20210096120A1

Автор: Alain Brzokewicz, Huguet Hélène

Принадлежит: GALDERMA RESEARCH & DEVELOPMENT

The invention relates to a method for determining in vitro release rate of at least one active principle ingredient from at least one semisolid form. 1. A method for determining in vitro release rate of at least one active principle ingredient from at least one semisolid form intended for topical routes of administration to skin or its appendages , using a composite multi-well microtitre plate , wherein each well comprises a donor compartment and a corresponding acceptor compartment adapted to receive the donor compartment , the bottom of the donor compartment is made of a porous membrane , the method comprising:a. Placing an aliquot of a semisolid form comprising at least one active principle ingredient in at least one donor compartment of the multi-well microtitre plate;b. Placing an initial acceptor medium in the corresponding acceptor compartment(s);c. Inserting the donor compartment in the corresponding acceptor compartment, so that the membrane in the bottom of the donor compartment is into contact with the initial acceptor medium;d. Collecting at at least two successive time intervals a sample of the acceptor medium in the acceptor compartment;e. Measuring the release rate of said active principle ingredient in each collected samples.2. The method of claim 1 , wherein the sample semisolid form placed in the donor compartments of the multi-well microtitre plate in step a) is different from a well to another.3. The method of claim 1 , wherein the membrane is a synthetic membrane.4. The method of claim 1 , wherein the membrane is a filter claim 1 , more preferably a microporous filter.5. The method of claim 1 , wherein the nature of the membrane is selected in the group consisting of: Polypropylene claim 1 , Polyethersulfone (PES) claim 1 , hydrophilic or hydrophobic polyvinylidenefluoride (PVDF) claim 1 , Mixed cellulose esters (MCE) claim 1 , hydrophilic or hydrophobic polytetrafluoroethylene claim 1 , nylon claim 1 , polycarbonate (PC) claim 1 , polyesters ( ...

Подробнее

Номер записи: 36

28-03-2019 дата публикации

METHOD AND DEVICE FOR PHYSICOCHEMICAL CHARACTERIZATION OF MATERIALS

Номер: US20190094197A1

Автор: Antikainen Osmo, Ehlers Henrik, Räikkonen Heikki, Svanbäck Sami, Yliruusi Jouko

Принадлежит:

An analysis method and device including detecting at least one particle of matter in a fluid inside in a reaction chamber and correlating a change in the particle to a physicochemical property of the matter. 3. (canceled)4. (canceled)5. The method of claim 1 , wherein the particle is immobilized on a permeable or semipermeable layer by using a pressure difference of the fluid over the permeable or semipermeable layer.6. The method of claim 1 , wherein step iv. comprises detecting at least one part of the particle.7. The method of claim 1 , wherein the particle has an original mass not higher than 100 mg claim 1 , preferably not higher than 100 μg claim 1 , more preferably not higher than 100 ng.8. The method of for determining ng claim 1 , preferably pg claim 1 , even more preferably fg claim 1 , most preferably ag changes in the mass of the particle.9. The method of claim 1 , wherein the particle is loaded on the surface using a fluid as a carrier.10. The method of claim 1 , wherein the particle is illuminated.11. The method of claim 1 , wherein the particle is detected through a window in the reaction chamber.12. The method of claim 1 , wherein detecting comprises detecting no change between two data points.13. The method of claim 1 , wherein the fluid is a supercritical fluid.14. The method of claim 1 , wherein the physicochemical property is solubility.15. An analysis device configured to carry out the method of comprisingA reaction chamber;At least one first inlet for passing a fluid into the reaction chamber;At least one outlet for passing fluid outside the reaction chamber;An immobilization zone arranged inside the reaction chamber configured to allow immobilizing particles in a fluid; andMeans allowing detecting the immobilization zone.16. The analysis device of claim 15 , wherein the means allowing detecting comprises a window arranged in a top plate claim 15 , bottom plate or in a wall defining the reaction chamber.17. The analysis device of claim 15 , ...

Подробнее

Номер записи: 37

12-05-2022 дата публикации

SURFACE TENSION MEASUREMENT METHOD BASED ON AXISYMMETRIC DROPLET CONTOUR CURVE

Номер: US20220148212A1

Автор: Li Huidong, LUO Caiyun, Tao Ye, Wang Jun, WANG Wenbing, XU Zijun, Yang Liping, Zhong Qiu

Принадлежит:

Disclosed is a method for measuring surface tension based on an axisymmetric droplet contour curve. The method comprises: photographing a suspended droplet image, and extracting a droplet contour curve; selecting a measurement point on the droplet contour curve; and calculating the surface tension of a liquid using the following formula 2. The method according to claim 1 , wherein when an upper end surface of the droplet is a plane claim 1 , the pressure P is obtained by the formula P=ΔρgH claim 1 , where H is a height of the cross section from the upper end surface of the droplet. The invention belongs to the technical field of physical property measurement, and relates to a surface tension measurement method based on an axisymmetric droplet contour curve.Surface tension is one of the most important thermophysical properties in fluid mechanics. It has an important influence on the heat and mass transfer of the fluid interface, as well as the flow and heat transfer of the micro-shrinkage channel, and thus has become the focus of related research. Surface tension measurement can provide relevant information about the interaction between gas and liquid, and liquid and liquid. From this information, it can be deduced that the material has various important characteristics such as adhesion, infiltration, biocompatibility, lubrication, and adsorption, so as to provide important support for the development of related science and technology.The measurement methods mainly include a maximum bubble method, a maximum tension method, a capillary method, a drop weight method, a droplet contour method, and the like. Among them, the droplet contour method requires fewer measurement samples, has higher accuracy and a wide use temperature range, which is widely applied. However, the droplet contour method includes performing a fitting solution to each point on the droplet profile, which involves differential equations and optimization solutions, and the solution process is ...

Подробнее

Номер записи: 38

26-03-2020 дата публикации

METHOD TO PREDICT DOWNHOLE RESERVOIR FLUIDS INTERFACIAL TENSION

Номер: US20200096429A1

Автор: ABDALLAH WAEL, Andersen Simon Ivar, BADRI MOHAMMED, Brady Dominic Joseph, Hamdy Mohamed Ahmed Abdel Reheem, Mahavadi Sharath Chandra, Sauerer Bastian

Принадлежит:

Methods may include emplacing a downhole tool within a wellbore, sampling a fluid downhole with the downhole tool; analyzing the fluid, and calculating an interfacial tension (IFT), wherein calculating the acid-base IFT contribution comprises measuring a concentration of a surface-active species directly. Apparatuses for measuring an interfacial tension (IFT) in a fluid downhole may be part of a downhole tool and may include a sampling head to sample the fluid; and a downhole fluid analysis module that includes a spectrometer capable of measuring a concentration of a surface-active species in the fluid, and a processor configured to determine the IFT of the fluid downhole based on the measured concentration of the surface-active species. 1. A method , comprising:emplacing a downhole tool within a wellbore;sampling a fluid downhole with the downhole tool;analyzing the fluid; and {'br': None, 'sub': HC', 'AB, 'γ=γ+γ'}, 'calculating an interfacial tension (IFT) for the fluid according to the formula{'sub': AB', 'HC, 'wherein γis the acid-base IFT contribution and γis the hydrocarbon fluid IFT contribution, and'}wherein calculating the acid-base IFT contribution comprises measuring a concentration of a surface active species directly.2. The method of claim 1 , wherein the concentration of surface active species is determined downhole.3. The method of claim 1 , wherein analyzing the fluid comprises using a spectrometer selected from a group consisting of: an infrared spectrometer claim 1 , a visible spectrometer claim 1 , an ultraviolet spectrometer claim 1 , and a fluorescence spectrometer.4. The method of claim 3 , wherein the spectrometer is an infrared spectrometer capable of measuring in the 1750-1700 cmrange.5. The method of claim 3 , wherein the spectrometer is a transmission spectrometer.6. The method of claim 3 , wherein the spectrometer is an attenuated total reflectance spectrometer.7. The method of claim 3 , wherein the spectrometer is configured to use ...

Подробнее

Номер записи: 39

19-04-2018 дата публикации

System and program for predicting the shearing by fluid Pressure

Номер: US20180106143A1

Автор: MIN Ki-Bok, PARK Sehyeok, XIE Linmao

Принадлежит:

The present disclosure relates to a system and program for predicting shearing by fluid pressure, the system and program capable of predicting shearing information such as the minimum pressure Prequired for hydraulic shearing, the sufficient pressure Pfor hydraulic shearing, and the optimal shearing direction using input information including the vertical stress σ, the maximum horizontal stress and the minimum horizontal stress of a rock to which fluid is to be injected, a joint friction angle φ, a reservoir rock density ρ, an injected fluid density, and a coefficient of the sufficient pressure for hydraulic shearing α. 1. A system for predicting shearing by fluid pressure , the system comprising:an interaction unit configured to provide a screen for inputting information necessary for shearing prediction and to provide a user with shearing information predicted according to input information; anda data processing unit configured to receive the input information from the interaction unit and to perform computation for predicting the shearing information,{'sub': v', 'r, 'wherein the input information includes a vertical stress σ, a maximum horizontal stress and a minimum horizontal stress of a rock to which fluid is to be injected, a joint friction angle φ, a reservoir rock density ρ, an injected fluid density, and a coefficient of a sufficient pressure α for hydraulic shearing, and'}{'sub': cm', 'co, 'based on an assumption that joints are distributed uniformly in all directions of a reservoir, the data processing unit predicts and provides a minimum pressure Prequired for hydraulic shearing, the sufficient pressure Pfor hydraulic shearing, and an optimal shearing direction using the input information.'}2. The system according to claim 1 ,{'sub': 'c', 'wherein the input information further comprises rock joint network data, and the data processing unit predicts and provides a pressure Prequired for hydraulic shearing, a shearing initiation location in a wellbore and ...

Подробнее

Номер записи: 40

09-06-2022 дата публикации

MESH FOR DISSOLUTION TEST

Номер: US20220178901A1

Автор: Horiuchi Kensuke, MATSUURA Satoyo, OKABE Maki

Принадлежит: Shionogi & Co., Ltd.

When the mesh is placed under the bottom of a blade and over the bottom of a vessel in the dissolution test assembly equipped with either a vessel specified in the dissolution test method of the Japanese Pharmacopoeia, the United States Pharmacopoeia or the European Pharmacopoeia or a vessel used for the dissolution test, and a paddle formed from a blade and a shaft, and the suspensions and the solid dosage forms are added to or placed at the said mesh, a drug dissolves from the said dosage forms and the dissolution ratio variation between the said multiple same dosage forms can be small. 1. A mesh for the dissolution test of suspensions or solid dosage forms , which is placed under the bottom of a blade and over the bottom of a vessel in a dissolution test assembly equipped with a vessel specified in the dissolution test method of the Japanese Pharmacopoeia , the United States Pharmacopoeia or the European Pharmacopoeia or a vessel used in the dissolution test , and a paddle comprising from a blade and a shaft.2. The mesh according to claim 1 , wherein the mesh is placed at 5 to 35 mm under the bottom of a blade.3. The mesh according to claim 1 , wherein the mesh is placed at 1 to 30 mm over the bottom of the vessel.4. The mesh according to claim 1 , wherein the mesh is placed at 5 to 35 mm under the bottom of a blade and at 1 to 30 mm over the bottom of the vessel.5. The mesh according to claim 1 , wherein the mesh is formed into a circle with a diameter between 10 and 95 mm.6. The mesh according to claim 1 , wherein the mesh has a sieve opening of 2 to 200 mesh.7. The mesh according to claim 1 , wherein the edge part is provided at the end of the mesh.8. The mesh according to claim 1 , wherein the leg part is provided with the mesh.9. The mesh according to claim 1 , to prevent coning of a suspension or a solid dosage forms in a dissolution test.10. A mesh for use in dissolution test of a suspension or solid dosage forms claim 1 , which is placed under the bottom ...

Подробнее

Номер записи: 41

25-04-2019 дата публикации

METHOD FOR DETERMINING DIFFUSION RADIUS OF IN-SITU INJECTION AND REMEDIATION OF CONTAMINATED SOIL AND GROUNDWATER

Номер: US20190120741A1

Автор: Chen Fan, CUI Shuangchao, Guo Lili, Li Shupeng, Liu Peng, Liu Yan, Niu Qiang, Song Xiaowei, YANG Yuewei, YIN Pengcheng, Zhang Xiaobin, ZHANG Yue

Принадлежит:

A method for determining the diffusion radius of in-situ injection and remediation of contaminated soil and groundwater. According to the triangle method, the hole spacing is perpendicular to the groundwater flow direction, the row spacing is along the groundwater flow direction, and the flow diffusion in the groundwater during the effective time of the remediation agent reaction is considered. Under high pressure rotary injection, the remediation agent and a certain proportion of bromide ions are simultaneously injected into the aquifer as a tracer. The diffusion of the agent is determined by observing the phenomenon of slurry-returning and slurry-channeling of adjacent injection points. After the completion of the injection, the groundwater is quickly sampled in fixed depth, the tracer concentration is quickly detected on site, and the concentration of bromide ions in the groundwater is compared with the background value. Comprehensive determination determines the optimal diffusion radius. 1. A method for determining the diffusion radius of in-situ injection and remediation of contaminated soil and groundwater , characterized in that ,step one: distributing and guided-boring: [{'br': None, 'i': L=', 'R, 'sub': '0', '1.73\u2003\u2003(1)'}, {'br': None, 'i': B=', 'R', '+B, 'sub': 0', '1, '1.50\u2003\u2003(2)'}, {'br': None, 'i': 'v=KI', '(3)'}, {'br': None, 'i': B', '=vt, 'sub': '1', '(4)'}], 'the in-situ injection holes distribution parameters satisfies the following formula{'sub': 0', '1, 'wherein L—the optimal holes spacing of the in-situ injection points, perpendicular to the groundwater flow direction; B—the optimal row spacing of in-situ injection points, along the groundwater flow direction; R—effective diffusion radius of the agent in the aquifer under high pressure injection conditions, unit: m; K—permeability coefficient of aquifer, unit: m/d; I—hydraulic gradient of groundwater; v—flow rate of groundwater, unit: m/d; t—effective reaction time of the agent ...

Подробнее

Номер записи: 42

25-04-2019 дата публикации

DEVICE, SYSTEM AND KIT FOR MEASURING TENSION OF SHEET-LIKE TISSUE CONTAINING CARDIOMYOCYTES

Номер: US20190120742A1

Автор: KAGAWA Yuki, KUBO Hirotsugu, SASAKI Daisuke, SHIMIZU Tatsuya, SHIOYAMA Takahiro

Принадлежит:

A device for measuring a tension of a sheet-like tissue containing cardiomyocytes includes a first gel adapter holder having a frame member and a first gel holding member protruding toward a part of an inside face of the frame member for fixing one end of a film-like gel; and a second gel adapter holder having a second gel holding member for fixing the other end of the gel and a connection member connected to the second gel holding member. A kit includes the tension measuring device; a substrate having a pair of gel molding protruding members fitted along the inside face of the frame member; and a gel forming lid body having a face parallel to a gel contact face of the substrate so as to form an upper face of the gel. Further, a system for measuring the tension includes the tension measuring device. 1. A device for measuring a tension of a sheet-like tissue containing cardiomyocytes comprising:a first gel adapter holder having a frame member and a first gel holding member protruding toward a part of an inside face of the frame member so as to fix one end of a film-like gel; anda second gel adapter holder having a second gel holding member for fixing the other end of the gel and a connection member connected to the second gel holding member,wherein the second gel adapter holder is attached to the first gel adapter holder so that the second gel holding member is opposed to the first gel holding member inside the frame member, andthe second gel adapter holder has a mechanism for sliding in an axial direction in which the first gel holding member and the second gel holding member are opposed to each other.2. The device according to claim 1 , wherein the first gel holding member has one or more first gel holding openings and the second gel holding member has one or more second gel holding openings.3. The device according to claim 2 , wherein two to five first gel holding openings and two to five second gel holding openings are provided.4. The device according to claim 1 ...

Подробнее

Номер записи: 43

16-04-2020 дата публикации

METHOD FOR MEASURING THE DIFFUSION COEFFICIENT OF WATER WITHIN A POROUS MEDIUM BY A NUCLEAR MAGNETIC RESONANCE METHOD

Номер: US20200116616A1

Автор: FLEURY Marc

Принадлежит:

The present invention relates to a method of measuring the diffusion coefficient of water in a porous medium, wherein the coefficient is measured using a nuclear magnetic resonance (NMR) technique () and wherein the sample () has the shape of a hollow cylinder. 110.-. (canceled)11. A method of measuring a diffusion coefficient of water in a porous medium , comprising:a) preparing a sample of the porous medium in a hollow cylinder;b) saturating the sample of the porous medium with water;c) immersing the water-saturated sample of the porous medium in a water-miscible tracer fluid which is not detectable by a Nuclear Magnetic Resonance NMR method;d) measuring the water concentration in the sample using a Nuclear Magnetic Resonance NMR method; ande) determining the water diffusion coefficient in the porous medium by use of the measured water concentration in the sample, by accounting for the hollow cylinder shape of the sample of the porous medium.12. A method as claimed in claim 11 , wherein the porous medium is one of a cement paste claim 11 , concrete or rock.13. A method as claimed in claim 12 , wherein the concrete contains aggregates which are millimeters in size.14. A method as claimed in claim 11 , wherein an outside diameter of the hollow cylinder ranges between 20 and 80 mm claim 11 , and an inside diameter of the hollow cylinder ranges between 2 and 25 mm.15. A method as claimed in claim 12 , wherein an outside diameter of the hollow cylinder ranges between 20 and 80 mm claim 12 , and an inside diameter of the hollow cylinder ranges between 2 and 25 mm.16. A method as claimed in claim 13 , wherein an outside diameter of the hollow cylinder ranges between 20 and 80 mm claim 13 , and an inside diameter of the hollow cylinder ranges between 2 and 25 mm.17. A method as claimed in claim 11 , wherein the tracer fluid which is not detectable by a Nuclear Magnetic Resonance NMR method is deuterium.18. A method as claimed in claim 12 , wherein the tracer fluid which ...

Подробнее

Номер записи: 44

01-09-2022 дата публикации

SYNCHRONOUS FLUORESCENCE DETECTOR FOR OBSERVING INTERFACE CONCENTRATION OF FLUORESCENT POLLUTANTS AND APPLICATION METHOD

Номер: US20220276166A1

Автор: Bao Lianjun, GONG Xiangjun, LIANG XIAO, QIU Xiawen, TIAN Wenzhang, ZENG Yongping, Zhang Guangzhao

Принадлежит: SOUTH CHINA UNIVERSITY OF TECHNOLOGY

Provided are a synchronous fluorescence detector for observing the interface concentration of fluorescent pollutants and application method. The detector comprises a first electric displacement platform, a quartz cuvette, an excitation light path, a collection light path and a second electric displacement platform. The application method comprises the following steps: first exciting fluorescent pollutants by utilizing UV light with specific wavelengths to emit fluorescent light; then collecting fluorescence signals emitted by the excited fluorescent pollutants to the greatest extent by utilizing an UV anti-reflection convex lens combination; and finally, processing the fluorescent signals acquired by a photomultiplier by utilizing a difference method to determine a precise light intensity of a thin layer which is moved at a specific spacing by utilizing the electric displacement platforms so as to determine fugacity distribution of the fluorescent pollutants in the microlayer near an interface. 1. A synchronous fluorescence detector for observing the interface concentration of fluorescent pollutants , comprising a first electric displacement platform , a quartz cuvette , an excitation light path , a collection light path and a second electric displacement platform ,wherein the excitation light path comprises a high-power xenon lamp optical fiber light source, a short wavelength pass filter, an UV collimator, a first UV anti-reflection convex lens and a second UV anti-reflection convex lens; the collection light source comprises a third UV anti-reflection convex lens, a fourth UV anti-reflection convex lens, a long wavelength pass filter and a photomultiplier;the excitation light path is arranged on the first electric displacement platform; the collection light path is arranged on the second electric displacement platform; the excitation light path and the collection light path are respectively close to the quartz cuvette; one side of the short wavelength pass filter ...

Подробнее

Номер записи: 45

19-05-2016 дата публикации

INSTALLATION AND METHOD FOR DETERMINING THE DIFFUSION PROFILE OF AT LEAST ONE MOLECULE THROUGH SKIN

Номер: US20160139020A1

Автор: Fujii Teruo, Gregoire Sébastien, Hadjur Christophe, Nicolas Alexandre, Provin Christophe

Принадлежит:

The invention relates to an installation () for determining the diffusion profile of at least one molecule through skin, comprising: 1. Installation for determining the diffusion profile of at least one molecule through skin , comprising: a donor compartment intended to contain a test solution comprising the or each molecule;', 'a receptor compartment intended to contain a receptor solution; and', 'a membrane with skin-mimetic barrier properties arranged between the donor compartment and the receptor compartment so that the test solution diffuses through the membrane from the donor compartment into the receptor compartment;, 'a microfluidic chip comprisingandan analyzer configured for measuring a physical parameter of the solution contained in the receptor compartment as the test solution diffuses through the membrane, and said analyzer being configured for measuring the physical parameter in the receptor compartment, the analyzer being further configured for calculating the diffusion profile of the or each molecule through skin from the measured physical parameter.2. Installation according to claim 1 , wherein the receptor compartment has a volume smaller than 250 mm.3. Installation according to claim 1 , wherein the physical parameter is related to the concentration of the or each molecule to be tested in the solution contained in the receptor compartment by a known mathematical function.4. Installation according to claim 1 , wherein the evolution of said physical parameter in time is representative of the diffusion of the or each molecule through the membrane.5. Installation according to claim 1 , wherein the physical parameter is chosen among the list comprising: an optical property of the solution contained in the receptor compartment claim 1 , an electrochemical property of the solution contained in the receptor compartment and the pH of the solution contained in the receptor compartment.6. Installation according to claim 1 , wherein the physical parameter ...

Подробнее

Номер записи: 46

07-08-2014 дата публикации

Tube and float system and methods of using the same

Номер: US20140219888A1

Автор: Daniel CAMPTON, Evan Castiglia, Joshua Nordberg

Принадлежит: Rarecyte Inc

This disclosure is directed to systems and methods for analyzing target materials of a suspension include a tube and a float. The float may include expandable portions. The system traps a target analyte between the expandable float and the tube and/or to create a seal between the expandable float and the tube to inhibit fluid from flowing past the expandable float in the tube. The expandable portions may radially expand when exposed to an expanding fluid, such that the expanding fluid is not a naturally-occurring constituent of the suspension; or, the expandable portions may radially expand when a force is exerted upon the expandable portion. A tube may include expandable portions that expand towards the float.

Подробнее

Номер записи: 47

26-05-2016 дата публикации

System For The Concomitant Assessment of Drug Dissolution, Absorption and Permeation and Methods of Using The Same

Номер: US20160146774A1

Автор: Hidalgo Ismael J., LI Jibin

Принадлежит:

Disclosed herein are devices, systems, and methods for assessing drug dissolution, absorption and permeation. 1. A device for assessing drug dissolution , absorption and permeation comprising:a chamber comprisinga reservoir having a bottom, at least one side wall, and a hollow interior, the side wall having an opening; andan extension having at least one side wall, a distal end, a proximal end, and a hollow interior, wherein the distal end and the proximal end are open, and wherein the proximal end is attached to the side wall at the opening;a permeability barrier having a least one side wall, an open distal end, and a proximal end, wherein the permeability barrier is configured to hold cells, tissues, or artificial membranes and the proximal end of the permeability barrier is configured to contact the distal end of the extension; anda securing cap having at least one side wall, a distal end, a proximal end, and a hollow interior, wherein the distal end and proximal end are open and wherein the securing cap is configured to reversibly attach to the permeability barrier or the extension,wherein the securing cap, permeability barrier, and chamber are in fluid communication.2. The device of claim 1 , wherein the top of the reservoir is open.3. The device of claim 1 , wherein the extension is perpendicular to the reservoir.4. The device of claim 1 , further comprising a seal configured for insertion between the distal end of the extension and the proximal end of the permeability barrier.5. The device of claim 4 , wherein the seal is an O-ring.6. The device of claim 1 , wherein the permeability barrier is configured to hold a layer of cells.7. The device of claim 1 , wherein the permeability barrier is configured to hold a tissue layer.8. The device of claim 1 , wherein the permeability barrier is configured to hold an artificial membrane layer.9. The device of claim 1 , wherein the device is configured to receive a permeability medium.10. A system for assessing drug ...

Подробнее

Номер записи: 48

25-05-2017 дата публикации

LOW PROFILE SHEAR-SENSING UNIT

Номер: US20170146439A1

Автор: Kim Chang-Jin, Xu Muchen

Принадлежит: The Regents of the University of California

A low-profile shear-sensing unit includes a floating plate surrounded by a frame and a displacement sensor that measures in-plane movement of the floating plate. Covered with a surface sample, the floating plate is displaced by the friction drag (i.e., shear) on the surface caused by the flow of fluid and the in-plane displacement is measured by the displacement sensor. The shear force on the sample surface is then obtained by multiplying the measured displacement and the spring constant of the flexure beams, which suspend the floating plate. The floating plate and the flexure beams are formed out of one plate or substrate to achieve monolithic construction with a beam geometry that leads to a high-resolution measurement. 1. A shear-sensing unit comprising:a frame plate;a floating plate disposed inside the frame plate in substantially the same plane with the frame plate and secured to the frame plate via a plurality of flexure beams disposed in substantially the same plane with the frame plate, the floating plate having a sample supporting surface and a back surface;a ruler secured to or formed on the back surface of the floating plate;a displacement sensor configured to sense in-plane movement of the ruler; andwherein the plurality of flexure beams are shaped to deform in a direction along a plane of the floating plate and wherein each of the plurality of flexure beams has a width smaller than 1 mm, a thickness larger than the width, and total length at least fifty (50) times larger than the width.2. The shear-sensing unit of claim 1 , wherein the measurement resolution is smaller than 100 μN.3. The shear-sensing unit of claim 1 , wherein the plurality of flexure beams comprises at least four (4) flexure beams.4. The shear-sensing unit of claim 1 , wherein each of the plurality of flexure beams has at least one fold.5. The shear-sensing unit of claim 1 , further comprising a sample on the sample supporting surface of the floating plate.6. The shear-sensing unit of ...

Подробнее

Номер записи: 49

31-05-2018 дата публикации

ORGANIC RESIDUE INSPECTING METHOD AND LIQUID DISCHARGE HEAD PRODUCING METHOD

Номер: US20180149572A1

Автор: Hamade Yohei, Ikegame Ken, Takahashi Hyou

Принадлежит:

A method of detecting an organic residue is provided. The method comprises a step of bringing a liquid A into contact with a surface of a base material; a step of measuring the contact angle (i) of a liquid B on the surface with which the liquid A came into contact; a step of heating and drying the base material; a step of measuring the contact angle (ii) of the liquid B on the dried surface; and a step of comparing the contact angle (i) with the contact angle (ii). 1. A method of detecting an organic residue on a surface of a base material , the method comprising:bringing a liquid A into contact with the surface of the base material;measuring a contact angle (i) of a liquid B on the surface with which the liquid A came into contact;heating and drying the base material;measuring a contact angle (ii) of the liquid B on the dried surface; andcomparing the contact angle (i) with the contact angle (ii).2. The method of detecting an organic residue according to claim 1 , further comprising:forming an organic film on the surface of the base material before bringing a liquid A into contact with the surface of the base material,the organic film on the surface of the base material is removed by bringing the liquid A into contact with the surface of the base material in the liquid A-bringing step.3. The method of detecting an organic residue according to claim 2 , wherein the organic film comprises cyclized rubber resin.4. The method of detecting an organic residue according to claim 2 , wherein the organic film comprises a positive photosensitive resin.5. The method of detecting an organic residue according to claim 1 , wherein the liquid A is at least one of a polar organic solvent and water.6. The method of detecting an organic residue according to claim 1 , wherein the liquid A is at least one of an organic solvent having a hydroxyl group and water.7. The method of detecting an organic residue according to claim 1 , wherein when an organic residue is present on the ...

Подробнее

Номер записи: 50

07-05-2020 дата публикации

Method and system for installing water potential detectors in plant stems, and for evaluating plant irrigation conditions

Номер: US20200141851A1

Автор: Anat HALGOA SOLOMON, Avishai AVNI, Erez SOKOLSKY, Moshe Meron, Yossi Gross

Принадлежит: SATURAS Ltd

The present invention provides devices, systems and methods for installing water potential detectors in plants stems, measuring the water potential in the plants, and evaluating crop irrigation conditions.

Подробнее

Номер записи: 51

17-06-2021 дата публикации

Device and method for determining a position and/or an extension of a drop

Номер: US20210181223A1

Автор: Alwin Schuller, Gerald ZERZA, Josef Grassl

Принадлежит: TECAN TRADING AG

A device for determining a position and/or an extension of a drop in a position determination space, where the device has a camera having an objective and a beam splitter in the recording area of the camera, and the device is designed in such a way that light coming from the position determination space can enter the objective of the camera along a first light path as well as along a second light path, where light along the first light path can be reflected at a first reflector element in the direction of the beam splitter and can be transmitted through the beam splitter towards the objective, and where light along the second light path can be reflected at a second reflector element in the direction of the beam splitter and can be reflected at the beam splitter towards the objective.

Подробнее

Номер записи: 52

14-05-2020 дата публикации

GAS DIFFUSION SIMULATION METHOD AND APPARATUS THEREFOR

Номер: US20200150014A1

Автор: Yamamoto Keiichi, YOROZUYA MISA

Принадлежит:

A gas diffusion simulation method for simulating diffusion of a gas in a porous material having many pores, the method includes: calculating, in the pores, a Knudsen diffusion coefficient based on the mean square displacement of first gas particles in spaces surrounded by wall surfaces and a Knudsen diffusion term using the Knudsen diffusion coefficient, calculating an interdiffusion term using an interdiffusion coefficient between the first gas particles and second gas particles different therefrom, and performing simulation of the gas diffusion of the first gas particles by using a diffusion equation of the first gas particles represented by the sum of the Knudsen diffusion term and the interdiffusion term. 1. A gas diffusion simulation method for simulating diffusion of a gas in a porous material having many pores , the method comprising:calculating, in the pores, a Knudsen diffusion coefficient based on the mean square displacement of first gas particles in spaces surrounded by wall surfaces and a Knudsen diffusion term using the Knudsen diffusion coefficient,calculating an interdiffusion term using an interdiffusion coefficient between the first gas particles and second gas particles different therefrom, andperforming simulation of the gas diffusion of the first gas particles by using a diffusion equation of the first gas particles represented by the sum of the Knudsen diffusion term and the interdiffusion term.2. The gas diffusion simulation method according to claim 1 ,wherein in the pores, the spaces surrounded by the wall surfaces are defined by positional information of the wall surfaces of the pores.3. The gas diffusion simulation method according to claim 1 ,wherein the wall surfaces of the pores are formed at least from surfaces of wall portions of the porous material surrounding peripheries of the pores.4. The gas diffusion simulation method according to claim 3 ,wherein the positional information of the wall surfaces of the pores is identified by ...

Подробнее

Номер записи: 53

14-05-2020 дата публикации

METHODS OF DETERMINING THE PROPERTIES OF A FLUID BODY

Номер: US20200150015A1

Автор: Robinson Anthony James, Siedel Samuel

Принадлежит:

A method is disclosed of determining the properties of a fluid body in the form of a surface-attached droplet/bubble. A data set is stored describing a plurality of droplets/bubbles of different shapes, in which each shape is captured as a combination of two or more linear dimensional measurements. For each shape the data set includes one or more parameters describing the relationship between the physical properties of a pair of fluids capable of forming that shape as a surface-attached droplet/bubble disposed in a surrounding fluid medium. A fluid body is provided in the form of a surface-attached droplet/bubble and a plurality of linear dimensional measurements are taken and are provided as an input to a processing apparatus. The processing apparatus determines from the data set the one or more parameters associated with the shape described by said linear dimensional measurements. In particular the surface tension of a fluid can be found in this way based on simple dimensional measurements. 1. A method of determining the properties of a fluid body in the form of a surface attached droplet/bubble , comprising the steps of:(a) storing, in a memory accessible by a processing apparatus, a set of data describing a plurality of droplets/bubbles of different shapes, wherein each shape is captured in said data set as a combination of two or more linear dimensional measurements, and wherein for each shape the data set includes one or more parameters describing the relationship between the physical properties of a pair of fluids capable of forming said shape when a first of said fluids is a surface-attached droplet/bubble disposed in a surrounding medium of the second of said fluids;(b) providing a fluid body as a surface-attached droplet/bubble of a first fluid in a surrounding medium of a different second fluid;(c) measuring a plurality of linear dimensional measurements of said fluid body;(d) providing said measurements as an input to a processing apparatus; and(e) said ...

Подробнее

Номер записи: 54

14-06-2018 дата публикации

METHOD FOR TREATING AN AQUEOUS LIQUID BY MEANS OF A FILTER DETERMINED AS A FUNCTION OF THE INTERFACIAL TENSION OF THE LIQUID

Номер: US20180162751A1

Автор: ARGILLIER Jean-Francois, BENOIT Antoine, Henaut Isabelle

Принадлежит:

The present invention relates to a method for treating an aqueous liquid comprising oil droplets and a surfactant and/or a base. For this method, a pore size threshold of a filter is determined taking into account the interfacial tension between the oil droplets and the water, and a filter is selected whose pore size is less than or equal to this threshold for filtration of the aqueous liquid. 1. A method for treating an aqueous liquid , the aqueous liquid comprising oil droplets and at least one surfactant and/or at least one base , wherein the following steps are carried out:a) determining the interfacial tension between the oil droplets and the water in the aqueous liquid, the interfacial tension being dependent upon the surfactant and/or the base;b) determining a pore size threshold of a filter for retaining the oil droplets from the aqueous liquid, the pore size threshold being a function of the interfacial tension;c) treating the aqueous liquid by filtration using a filter for which the size of the pores is less than or equal to the pore size threshold.2. The method as claimed in claim 1 , wherein the pore size threshold of the filter is determined by means of a threshold capillary number.5. The method as claimed in claim 3 , wherein the viscosity of the aqueous liquid is determined by measurement claim 3 , notably using a rheometer.6. The method as claimed in claim 1 , wherein the interfacial tension is determined by measurement claim 1 , or as a function of the concentration and of the type of the surfactant and/or of the base.7. The method as claimed in claim 1 , wherein the shear rate is determined as a function of the flow rate of the aqueous liquid in the filter.8. The method as claimed in claim 1 , wherein said filtration is a dead-end or tangential membrane filtration with flow of said aqueous liquid.9. The method as claimed in claim 8 , wherein the filter is a polymeric claim 8 , or metallic or ceramic membrane.10. A method for treating a petroleum ...

Подробнее

Номер записи: 55

29-09-2022 дата публикации

APPARATUS AND METHODS FOR THE QUALITATIVE AND QUANTITATIVE DETECTION OF AMPHIPHILES

Номер: US20220307961A1

Автор: Brady Patrick Richard

Принадлежит:

Methods, apparatus, and kits for detecting and optionally quantifying amphiphilic compounds in the environment, in media samples, and on objects by determining an initial surface energy of a surface of a sample substrate, exposing the sample substrate surface to a medium that contains or is suspected to contain an amphiphilic compound for a time sufficient for the amphiphilic compound to interact with the sample substrate surface, determining a post-exposure surface energy of the surface of the sample substrate, determining a change in the surface energy of the sample substrate surface, and correlating the determined change in surface energy of the sample substrate surface with a presence and/or character of amphiphilic compounds in the medium. 1. A method of analyzing a sample medium , comprising:determining an initial surface energy of a surface of a sample substrate;exposing the sample substrate surface to a medium that contains or is suspected to contain an amphiphilic compound for a time sufficient for the amphiphilic compound to interact with the sample substrate surface;determining a post-exposure surface energy of the surface of the sample substrate;determining a change in surface energy of the sample substrate surface by comparing the determined initial surface energy to the determined post-exposure surface energy; andcorrelating the determined change in surface energy of the sample substrate surface with a presence and/or a character of amphiphilic compounds in the medium.2. The method of claim 1 , further comprising quantifying a concentration of amphiphilic compounds in the medium from the determined change in surface energy of the sample substrate.3. The method of claim 1 , wherein exposing the sample substrate surface to a medium that contains or is suspected to contain an amphiphilic compound includes exposing the sample substrate surface to a medium that is an environmental sample.4. The method of claim 1 , wherein exposing the sample substrate ...

Подробнее

Номер записи: 56

02-07-2015 дата публикации

METHODS, DEVICES AND SYSTEMS FOR EMULSION/DROPLET PCR

Номер: US20150184151A1

Автор: Pandit Kunal, Raghavan Srinivasa, White Ian M.

Принадлежит: CANON U.S. LIFE SCIENCES, INC.

The present invention relates generally to the use of a class of surfactants for emulsion and droplet polymerase chain reaction (“PCR”) mixtures. The class of surfactants consists of those having the chemical formula R—(OCHCH)—OH, wherein R is an alkyl group consisting of 12 to 18 carbons and n is 2 to 25. The present invention also relates to methods, devices, systems, and kits incorporating the above-described class of surfactants. 1. A droplet or emulsion polymerase chain reaction (PCR) mixture comprising:an aqueous droplet comprising a polymerase chain reaction mixture;an oil phase; and{'sub': 2', '2', 'n, 'a surfactant having Formula I: R—(OCHCH)—OH,'}wherein R is an alkyl group consisting of 12 to 18 carbons and n is 2 to 25.2. The droplet or emulsion PCR mixture of claim 1 , wherein the polymerase chain reaction mixture comprises a polymerase claim 1 , a primer claim 1 , nucleotides claim 1 , and a template nucleic acid.3. The droplet or emulsion PCR mixture of claim 1 , wherein the surfactant is selected from the group consisting of laureth-4 claim 1 , laureth-23 claim 1 , ceteth-2 claim 1 , ceteth-20 claim 1 , ceteareth-12 claim 1 , ceteareth-20 claim 1 , ceteareth-25 claim 1 , steareth-2 claim 1 , steareth-10 claim 1 , steareth-20 claim 1 , steareth-21 claim 1 , oleth-2 claim 1 , oleth-5 claim 1 , oleth-10 claim 1 , and oleth-20.4. The droplet or emulsion PCR mixture of claim 3 , wherein the surfactant is laureth-4.5. The droplet or emulsion PCR mixture of claim 2 , wherein the polymerase is Taq polymerase.6. The droplet or emulsion PCR mixture of claim 1 , wherein the oil phase comprises mineral oil.7. The droplet or emulsion PCR mixture of claim 1 , wherein the aqueous droplet is surrounded by the oil phase and the surfactant.9. The method of claim 8 , wherein the polymerase chain reaction mixture comprises a polymerase claim 8 , a primer claim 8 , nucleotides claim 8 , and a template nucleic acid.10. The method of claim 9 , wherein the surfactant is ...

Подробнее

Номер записи: 57

22-06-2017 дата публикации

Method for determining the permeation of a permeant through a membrane

Номер: US20170176314A1

Автор: Alexander Chapman, David Goodall, Edmund Bergstrom

Принадлежит: Paraytec Ltd

The present invention relates to a method of (and system for) characterising the permeation of a permeant of interest between a first liquid or semi-solid and a second liquid across an interface (eg through a membrane) by using UV imaging.

Подробнее

Номер записи: 58

08-07-2021 дата публикации

Diffusive gradients in thin films (dgt) probe test device for sediment core in lake and test method using the same

Номер: US20210208031A1

Автор: Bo Zhang, Cheng Yao, Junyi CHEN, Kun Wang, Li Zhao, Qing Cai, Shuhang Wang, Wenwen WANG, Xia Jiang, Zhihao WU

Принадлежит: CHINESE RESEARCH ACADEMY OF ENVIRONMENTAL SCIENCES

The present disclosure provides a diffusive gradients in thin films (DGT) probe test device for a sediment core in a lake, including: a sampling tube, where, a settlement limit device is disposed on an outer wall of the sampling tube and a DGT probe and a multi-parameter water-quality detection electrode are installed within the sampling tube; a movable mudguard device comprising a connecting rod and a mudguard, where, the connecting rod rotates around a rotating shaft to drive the mudguard to move from a position where an opening at the lower end of the sampling tube is sealed to a side of the sampling tube; a position-limit mechanism removably installed outside the sampling tube; a hammering device located above the sampling tube and fixedly connected to the sampling tube; and a floating ball located above the hammering device and connected to the hammering device via a first pull rope.

Подробнее

Номер записи: 59

16-07-2015 дата публикации

METHODS AND APPARATUS TO DETERMINE INTEGRITY OF COMPOSITE STRUCTURES

Номер: US20150198514A1

Автор: Dan-Jumbo Eugene A.

Принадлежит: The Boeing Company

Apparatus and methods to determine structural integrity of composites are described herein. One described example method for determining sufficiency of structural integration of a composite structure for an aircraft includes applying a fluid droplet to a surface of the composite structure, determining a three-dimensional contact angle between the surface and a portion of the droplet, comparing the three-dimensional contact angle to a threshold angle, and determining whether the structural integration of the composite structure is sufficient based on the comparison. 1. A method for determining sufficiency of structural integration of a composite structure for an aircraft , the method comprising:applying a fluid droplet to a surface of the composite structure;determining a three-dimensional contact angle between the surface and a portion of the droplet;comparing the three-dimensional contact angle to a threshold angle; anddetermining whether the structural integration of the composite structure is sufficient based on the comparison.2. The method as defined in claim 1 , further comprising selecting the composite structure for integration into an assembly when the structural integration is sufficient.3. The method as defined in claim 1 , further comprising approving the composite structure when the structural integration is sufficient after integration of the composite structure into an assembly.4. The method as defined in claim 1 , wherein the three-dimensional contact angle being less than the threshold angle indicates sufficient structural integration of the composite structure.5. The method as defined in claim 1 , wherein the three-dimensional contact angle being greater than the threshold angle indicates insufficient structural integration of the composite structure.6. The method as defined in claim 1 , wherein determining the three-dimensional contact angle comprises measuring a diameter and volume of the droplet.7. The method as defined in claim 1 , wherein the ...

Подробнее

Номер записи: 60

05-07-2018 дата публикации

METHOD AND APPARATUS FOR DETERMINING DIFFUSION PROPERTIES OF A SAMPLE

Номер: US20180188147A1

Автор: BARKER NÉE LESZCZYSZYN Oksana, BOTT Rachel, HAMPTON Karl, LATUNDE-DADA Seyi

Принадлежит: Malvern Instruments Ltd.

A method of determining a relationship between a mutual diffusion co-efficient Dand the concentration c of a solute within a solvent. The method comprises: obtaining a Taylorgram comprising a plurality of measurements of solute concentration c; and deriving from the Taylorgram a plurality of mutual diffusion coefficient values Dcorresponding with a plurality of different concentrations c of solute in the solvent. 1. A method of determining a relationship between a mutual diffusion co-efficient Dand the concentration c of a solute within a solvent , comprising:obtaining a Taylorgram comprising a plurality of measurements of solute concentration c;{'sub': 'm', 'deriving from the Taylorgram a plurality of mutual diffusion coefficient values Dcorresponding with a plurality of different concentrations c of solute in the solvent.'}2. The method of claim 1 , wherein the method further comprises fitting a function to the Taylorgram.5. The method of claim 4 , wherein the mutual diffusion coefficient values Dare derived from the function that is fitted to the Taylorgram and from the rate of change of concentration with respect to time.11. The method of claim 1 , further comprising determining a diffusion interaction parameter kof the solute in the solution from the relationship D(c) between the mutual diffusion coefficient values Dand the corresponding concentrations c.12. The method of claim 11 , further comprising determining the second virial coefficient Afrom the diffusion interaction parameter kand an estimate of the coefficient of friction kand an estimate of the partial specific volume vof the solute.13. The method of claim 1 , further comprising estimating a measure of aggregation of solute particles from the values of the mutual diffusion coefficient over the duration of the Taylorgram.14. An apparatus claim 1 , comprising a processor claim 1 , configured to perform the method of .15. The apparatus of claim 14 , further comprising an instrument for performing a ...

Подробнее

Номер записи: 61

20-06-2019 дата публикации

MICROHEATER INTEGRATED TEMPERATURE CONTROLLABLE MICROFLUIDIC TENSIOMETER FOR MEASURING DYNAMIC INTERFACIAL TENSION

Номер: US20190187034A1

Автор: FRIED Amy Shen, Lee Doojin

Принадлежит: OKINAWA INSTITUTE OF SCIENCE AND TECHNOLOGY SCHOOL CORPORATION

A temperature-controllable microfluidic device includes: a microfluidic channel generally extending in a first direction for passing a specimen fluid; a microheater disposed along the microfluidic channel, the microheater being made of a resistive wire having a pair of serpentine-shaped portions generally extending in the first direction along respective sides of the microfluidic channel; and a temperature sensor disposed along the microfluidic channel, the temperature sensor being made of a resistive wire having a pair of serpentine-shaped portions generally extending in the first direction along the respective sides of the microfluidic channel. 1. A temperature-controllable microfluidic device , comprising:a microfluidic channel generally extending in a first direction for passing a specimen fluid;a microheater disposed along the microfluidic channel, the microheater being made of a resistive wire having a pair of serpentine-shaped portions generally extending in the first direction along respective sides of the microfluidic channel; anda temperature sensor disposed along the microfluidic channel, the temperature sensor being made of a resistive wire having a pair of serpentine-shaped portions generally extending in the first direction along the respective sides of the microfluidic channel.2. The temperature-controllable microfluidic device according to claim 1 , wherein said pair of serpentine-shaped portions of the temperature sensor is disposed alongside said pair of serpentine-shaped portions of the microheater at outer sides thereof relative to the microfluidic channel.3. The temperature-controllable microfluidic device according to claim 1 , wherein said pair of serpentine-shaped portions of the temperature sensor and said pair of serpentine-shaped portions of the microheater both have a rectangular wave shape.4. The temperature-controllable microfluidic device according to claim 1 , wherein said microheater and said temperature sensor are disposed on a ...

Подробнее

Номер записи: 62

30-07-2015 дата публикации

CONTACT ANGLE MEASUREMENT APPARATUS

Номер: US20150211973A1

Автор: FRIEDRICH Bernd, SCHEITHAUER Carsten, WESER Florian

Принадлежит:

A contact angle measurement apparatus includes a liquid reservoir arrangement, a drop dosing device in fluid communication with the liquid reservoir arrangement and adapted for applying a liquid drop onto a sample surface, an illuminating device for illuminating each drop applied by the drop dosing device and disposed on the surface from a first side, and an image recording device for recording an image of each applied drop disposed on the surface. A liquid pressurizing system is adapted to pressurize liquid from the liquid reservoir arrangement, and a controller connected to the valve of each drop dosing device and to the liquid pressurizing system, which controls the operation of the liquid pressurizing system and, for each drop dosing device, opening and closing of the respective valve to apply a drop of the respective liquid from the respective liquid line to the surface in a jet of pressurized liquid. 1. A contact angle measurement apparatus for measuring a contact angle between a surface of a solid sample body and at least one drop of sample liquid disposed on the surface , the apparatus comprising:a liquid reservoir arrangement for storing at least one liquid,at least one drop dosing device in fluid communication with the liquid reservoir arrangement and adapted and arranged for applying a drop of a liquid stored in the liquid reservoir arrangement onto a surface of a sample body,an illuminating device adapted and arranged for illuminating each drop applied by the at least one drop dosing device and disposed on the surface from a first side of the at least one drop, andan image recording device adapted and arranged for recording an image of at least a transition region between the surface and each drop applied by the at least one drop dosing device and disposed on the surface in side view from a second side of the drop opposite the first side,characterized in thateach of the at least one drop dosing device comprises a liquid line, which comprises an outlet ...

Подробнее

Номер записи: 63

29-07-2021 дата публикации

MODIFIED FRANZ CELL

Номер: US20210231547A1

Автор: FRENZEL Franziska, KÜNZIG Katrin, LODDER-GADACZEK Julia, UHRMACHER Tanja

Принадлежит:

The present invention relates to an acceptor chamber for a Franz diffusion cell, comprising an upper opening closable by a membrane and, on the side wall of the acceptor chamber, an upper and a lower outlet opening designed to remove or add liquid medium from the acceptor chamber, the upper outlet opening being located within the upper two thirds of the side wall and the lower outlet opening is located in the lower quarter of the side wall, the upper and lower outlet openings being substantially opposite each other, to a Franz diffusion cell comprising a donor compartment and such an acceptor chamber, the donor compartment and the acceptor chamber being separated from each other by a membrane, and to a method for determining the diffusion of a substance through a membrane with such a Franz diffusion cell. 1. An acceptor chamber for a Franz diffusion cell , comprising an upper opening closable by a membrane and , on the side wall of the acceptor chamber , an upper and a lower outlet opening designed to remove or add liquid medium from the acceptor chamber , wherein the upper outlet opening is placed within the upper two thirds of the side wall and the lower outlet opening is placed in the lower quarter of the side wall , characterised in that the upper and lower outlet openings are located substantially opposite each other.2. The acceptor chamber according to claim 1 , characterised in that the upper and/or the lower outlet opening is reclosable.3. The acceptor chamber according to claim 1 , characterised in that the acceptor chamber has the basic shape of a cylinder claim 1 , cuboid or cube.4. The acceptor chamber according to claim 1 , characterised in that the lower outlet opening is arranged flush with the bottom of the acceptor chamber.5. The acceptor chamber according to claim 1 , characterised in that the upper outlet opening is placed within the upper third of the side wall.6. The acceptor chamber according to claim 1 , characterized in that the acceptor ...

Подробнее

Номер записи: 64

29-07-2021 дата публикации

METHOD AND APPARATUS FOR INSPECTION OF PAPER BOBBINS

Номер: US20210231635A1

Автор: Ademe Balager

Принадлежит:

An apparatus adapted to examine a paper web includes a rotatable first bobbin, a rotatable second bobbin, and a first testing device. The first bobbin has a paper we wound thereabout that has transverse bands spaced apart along a length thereof. The second bobbin is arranged to receive the paper web from the first bobbin with a paper web path defined between the first and second bobbins. The first testing device is disposed along the paper web path and is arranged to nondestructively measure a diffusivity of one of the transverse bands of the paper web. 1. An apparatus adapted to examine a paper web , the apparatus comprising:a rotatable first bobbin configured to accept a paper web, the paper web having transverse bands spaced apart along a length thereof;a rotatable second bobbin arranged to receive the paper web from the first bobbin with a paper web path defined between the first and second bobbins; anda first testing device disposed along the paper web path and arranged to nondestructively measure a diffusivity of one of the transverse bands of the paper web.2. The apparatus according to claim 1 , further comprising a second testing device disposed along the paper web path and arranged to nondestructively measure a porosity of one of the transverse bands.3. The apparatus according to claim 2 , wherein the second testing device is spaced apart along the paper web path from the first testing device by a distance corresponding to a distance between transverse bands of the paper web such that when one of the transverse bands is in registration with the first testing device another one of the transverse bands is in registration with the second testing device.4. The apparatus according to claim 1 , further comprising a pattern detection device disposed along the paper web path prior to the first testing device and arranged to interact with the paper web to detect the transverse bands.5. The apparatus according to claim 4 , wherein the pattern detection device is in ...

Подробнее

Номер записи: 65

19-07-2018 дата публикации

ARTIFICIAL GUT SIMULATOR AND METHOD

Номер: US20180202987A1

Автор: Siegel Ronald A.

Принадлежит:

An artificial gut simulator and methods are shown. In one example, the artificial gut simulator and methods provide accurate dissolution data by removing detected test sample material from the tester over time. 1. An artificial gut simulator , comprising:a test sample dissolution container;a conduit passing through the test sample dissolution container, the conduit including a semi-permeable membrane adapted to allow the transport of a selected test sample component through the semi-permeable membrane, while excluding other components from within the test sample dissolution container;a pump to drive an amount of medium through the conduit over time; anda detector to quantify an amount of the selected test sample component over time that has passed from the test sample dissolution container, through the semi-permeable membrane, and into the medium.2. The artificial gut simulator of claim 1 , wherein the selected test sample component includes a pharmaceutical drug.3. The artificial gut simulator of claim 1 , wherein the pharmaceutical drug includes a supersaturated solid dosage form pharmaceutical drug.4. The artificial gut simulator of claim 1 , further including a stirring device within the test sample dissolution container.5. The artificial gut simulator of claim 1 , further including a fluid sampling port to access the test sample dissolution container during testing.6. The artificial gut simulator of claim 1 , further including a fiber optic viewing device to monitor the test sample dissolution container during testing.7. The artificial gut simulator of claim 1 , wherein the semi-permeable membrane includes a hollow fiber coil.8. The artificial gut simulator of claim 1 , wherein the detector includes a continuous analyzer.9. The artificial gut simulator of claim 8 , wherein the continuous analyzer includes a UV detector.10. A method of drug dissolution testing claim 8 , comprising:placing a drug test sample in a test sample dissolution container;pumping a medium ...

Подробнее

Номер записи: 66

27-07-2017 дата публикации

SYSTEM AND PROCESS FOR ANALYZING THE INTERACTION BETWEEN A DROP OF FLUID AND ANOTHER DROP OR A SOLID SURFACE

Номер: US20170212027A1

Автор: CAGNA Alain, ESPOSITO Gérard

Принадлежит: TECLIS

The invention relates to a system and a process for analyzing the interaction between a drop of fluid which is immiscible in an ambient medium and a surface, this surface being another drop of fluid or else alternatively a solid surface. The system also comprises processing means suitable for determining, according to data collected by an image acquisition and processing device, a value of interfacial tension of the drop after a contact between the drop and the surface, and a value of pressure difference between the internal pressure of the drop and the pressure in the ambient medium without having to know the position of the apex of the drop. The invention also relates to a device for forming drops and bringing drops into contact and to a device for forming a drop of fluid and bringing a drop of fluid into contact with a solid surface for the purpose of analyzing them by means of the appropriate system. 1. A device for forming and bringing into contact drops of fluids which are immiscible in an ambient medium , comprising:a first capillary tube comprising an end capable of opening out into the ambient medium and a rectilinear end portion extending vertically from the end of the first capillary tube, conveying a first fluid through the first capillary tube to the end of the first capillary tube, and', 'controlling a volume of a first drop of first fluid formed at the end of the first capillary tube,, 'a first syringe-driver assembly connected to the first capillary tube and suitable fora second capillary tube comprising an end capable of opening out into the ambient medium and a rectilinear end portion extending vertically from the end of the second capillary tube, conveying a second fluid through the second capillary tube to the end of the second capillary tube, and', 'controlling a volume of a second drop of a second fluid formed at the end of the second capillary tube in the ambient medium,, 'a second syringe-driver assembly connected to the second capillary tube ...

Подробнее

Номер записи: 67

27-07-2017 дата публикации

Method for Determining Whether Reconstitution of a Solution in a Container is Completed

Номер: US20170212068A1

Автор: LÜMKEMANN Jörg, Mahler Hanns-Christian, Rietmann Rene, Steiner Roger, WERK Tobias

Принадлежит:

A method for determining whether reconstitution of a solution in a container is completed comprises the steps of: 1. A method for determining whether reconstitution of a solution in a container is completed , the method comprising the steps of:selecting a predetermined amount of a solid substance and a predetermined amount of a liquid solvent from which the reconstituted solution is to be prepared, the predetermined amount of the solid substance and of the liquid solvent being selected such that the reconstituted solution is below its saturation limit,preparing a solution by solving in the container the predetermined amount of the solid substance in the predetermined amount of the liquid solvent,measuring a value chosen from impedance (Z) or resistance (R) of the solution in the container,determining whether a change of the measured value within a measuring time interval of a predetermined duration is below a defined threshold, anddetermining that reconstitution of the solution is completed and that the reconstituted solution is formed when the change of the measured value within the measuring time interval of the predetermined duration is below the defined threshold.2. A method according to claim 1 , wherein the value is the impedance (Z) of the solution.3. A method according to claim 1 , wherein the value is the resistance (R) of the solution.4. A method according to claim 1 , wherein the change of the measured value within the measuring time interval of the predetermined duration is below the threshold of 0.01%-5%.5. A method according to claim 1 , further comprising the steps of:{'sub': 'R', 'determining a reconstitution time (t) of the solution in the container to be the duration between the time of starting to prepare the solution and the time at which the change of the measured impedance (Z) or resistance (R) of the solution is below the defined threshold within the measuring time interval of the predetermined duration.'}6. A method according to claim 1 , ...

Подробнее

Номер записи: 68

04-07-2019 дата публикации

WETTABILITY TESTER

Номер: US20190204198A1

Автор: Amiya Kenji, FUKUDA Yasuyuki, KIDACHI Haruka, MAKABE Eiichi

Принадлежит:

There is provided a wettability tester using a test material in a molten state, including: a chamber; a vacuum exhaust section exhausting the chamber; a gas supply section supplying a predetermined gas into the chamber; a sample stage disposed in the chamber; and an observation section observing morphological change associated with a temperature distribution in the test material tapped onto the sample stage, wherein the vacuum exhaust section and the gas supply section establish a vacuum atmosphere, an inert gas atmosphere, a reducing atmosphere or an air atmosphere in the chamber. It is preferable to include: a melting section disposed above the sample stage and transforming the test material into a molten state; and a tapping control section causing the test material transformed into a molten state by the melting section to be tapped. 1. A wettability tester using a test material in a molten state , comprising:a chamber;a vacuum exhaust section exhausting the chamber;a gas supply section supplying a predetermined gas into the chamber;a sample stage disposed in the chamber; andan observation section observing morphological change associated with a temperature distribution in the test material tapped onto the sample stage,wherein the vacuum exhaust section and the gas supply section establish a vacuum atmosphere, an inert gas atmosphere, a reducing atmosphere or an air atmosphere in the chamber.2. The wettability tester according to claim 1 , including:a melting section disposed above the sample stage and transforming the test material into a molten state; anda tapping control section causing the test material transformed into a molten state by the melting section to be tapped.3. The wettability tester according to claim 2 ,wherein the tapping control section includes a dropping control section causing the test material melted in a nozzle by the melting section to be dropped or a flow rate adjustment section causing the test material melted in the nozzle by the ...

Подробнее

Номер записи: 69

04-07-2019 дата публикации

Device, method and kit for dissolution testing

Номер: US20190204286A1

Автор: Ilkka LASSILA, Jenni PESSI, Jouko Yliruusi, Sami Svanbäck

Принадлежит: Nanoform Finland Oy

Disclosed are devices and methods for dissolving sample substances such as drug molecules. Also disclosed is use of the method for device for testing dissolution rates of the sample substances. It utilizes lyophilic matrices that create conditions for discriminating the dissolved sample substance from undissolved sample substances. This is aimed at preventing dispersion of the undissolved sample substance to avoid any substantial membrane effects.

Подробнее

Номер записи: 70

16-10-2014 дата публикации

APPARATUS AND METHOD FOR VISIOMETRIC DISINTEGRATION

Номер: US20140305225A1

Автор: Desai Parind Mahendrakumar, Heng Paul Wan Sia, Liew Celine Valeria

Принадлежит: NATIONAL UNIVERSITY OF SINGAPORE

In one version of the invention, an apparatus intended for determining the disintegration time of rapidly disintegrating tablets is designed with a disintegration cell having two liquid inlets and outflow from the top. Visualization of tablet inside the disintegration cell is conducted using a camera aided by a base light source and images captured using a computer or any other recording system. Disintegration medium is introduced into the disintegration cell through both inlets to produce a swirling motion and images of the tablet disintegration process are captured. The captured images are analyzed in real-time or off-line, to determine the tablet disintegration time. A visual non-recording method using projected image may also be used. 1. An apparatus for determining the disintegration time of a disintegrating dosage form , the apparatus comprising:a disintegration cell configured to contain the dosage form; anda plurality of liquid jet inlets configured to introduce a disintegration medium into the disintegration cell to produce a swirling shear force of the disintegration medium within the disintegration cell;the disintegration cell comprising an overhead outlet configured to remove, from the disintegration cell, overflowing disintegration medium and a plurality of disintegrated fragments of the dosage form.2. An apparatus according to claim 1 , wherein the disintegration cell is configured to permit visualization of the dosage form through at least a portion of the disintegration cell.3. An apparatus according to claim 2 , wherein the disintegration cell comprises a transparent surface configured to allow passage of light from a light source to permit visualization of the dosage form.4. An apparatus according to claim 2 , wherein the disintegration cell comprises a reflecting surface configured to reflect light claim 2 , received from a light source claim 2 , to permit visualization of the dosage form.5. An apparatus according to claim 2 , further comprising a ...

Подробнее

Номер записи: 71

04-08-2016 дата публикации

WATER TENSION SENSOR, SYSTEM FOR CHARACTERISING AND CONTINUOUSLY MEASURING SOIL WATER, SYSTEM FOR INDICATING CRITICAL SOIL WATER TENSION AND IRRIGATION ROD

Номер: US20160223450A1

Автор: Aparecido Marouelli Waldir, Gimenez Calbo Adonai, Pedro Vaz Carlos Manoel, Porto Luis Fernando

Принадлежит:

The present invention provides a water tension sensor with a non-sintered core that allows batches of similar and standard sensors to be manufactured in a simple manner, for operation with air and with an air flow outlet, which sensor can be used to read water tension and trigger dripping. The sensor according to the invention is ideal for manually reading soil water tension and for automating irrigation systems based on a static pressure or gas propulsion mechanism. 194-. (canceled)95. Water tension sensor comprising a non-sintered core enveloped by a porous support element , said core limited at its ends by porous blocks connected to an air inflow duct and an air outflow duct.96. Water tension sensor as claimed in claim 95 , wherein the non-sintered core is made of hydrophilic material.97. Water tension sensor as claimed in claim 96 , wherein the hydrophilic material has a cosine of the contact angle greater than 0.9.98. Water tension sensor as claimed in claim 95 , wherein the non-sintered core is made of material selected from among corundum and glass spheres.991. Water tension sensor as claimed in claim 95 , wherein the porous support element () is made of hydrophilic material.100. Water tension sensor as claimed in claim 99 , wherein the hydrophilic material has a cosine of the contact angle than 0.9.101. Water tension sensor as claimed in claim 95 , wherein the porous support element is made of material selected from the group consisting of ceramic claim 95 , gypsum claim 95 , and pervious concrete.102. Water tension sensor as claimed in claim 95 , wherein the porous blocks are made of elastic porous materials.1032. Water tension sensor as claimed in claim 95 , wherein the porous support element has a bubbling pressure 4 times greater than the critical tension of the non-sintered core ().1046. Water tension sensor as claimed in claim 95 , further comprising a measuring device adjacent to said sensor ().105. Water tension sensor as claimed in claim 104 , ...

Подробнее

Номер записи: 72

23-10-2014 дата публикации

DETERMINATION OF INTERFACIAL OR SURFACE TENSION

Номер: US20140311229A1

Автор: ABDALLAH WAEL, Clarke Andrew, Ligneul Patrice, STUKAN MIKHAIL

Принадлежит: SCHLUMBERGER TECHNOLOGY CORPORATION

A method and apparatus for measuring interfacial or surface tension of a first fluid dispersed in a second fluid, the method involving providing at least one substantially spherical droplet or bubble of the first fluid in a flowing stream of the second fluid in a flow channel, followed by passing the flowing stream comprising the droplet or bubble through a constriction in the flow channel, the constriction being sufficiently constricting so as to cause the droplet or bubble to deform away from its substantially spherical shape and measuring and comparing a physical property of the flowing stream both before and after the constriction, wherein the physical property changes as a result of the deformation of the droplet or bubble, and thereby inferring the interfacial or surface tension from the measured physical property. 1. A method of measuring interfacial or surface tension of a first fluid dispersed in a second fluid , the method comprising:providing at least one substantially spherical droplet or bubble of the first fluid in a flowing stream of the second fluid in a flow channel;passing the flowing stream comprising the droplet or bubble of the first fluid through a constriction in the flow channel, wherein the constriction is sufficiently constricting so as to cause the droplet or bubble to deform away from its substantially spherical shape;at least one of measuring and comparing a physical property of the flowing stream before and after the constriction, wherein the physical property changes as a result of the deformation of the droplet or bubble as it passes through the constriction; anddetermining the interfacial or surface tension of the first fluid from at least one of the measured physical property and the compared physical property.2. A method according to claim 1 , wherein the measured physical property of the flowing fluid comprises a pressure difference measured across the constriction as the droplet or bubble passes through the constriction.3. A ...

Подробнее

Номер записи: 73

12-08-2021 дата публикации

Steeply-inclined ultra-thick coal seam gas control method based on binary composite liquid

Номер: US20210246767A1

Автор: Gang Wang, Hao Xu, Jianqiang Chen, Kunlun LIU, Lulu Sun, Sanlong ZHENG, Xiangyu Tang, Zhiyuan Liu

Принадлежит: SHANDONG UNIVERSITY OF SCIENCE AND TECHNOLOGY

A steeply-inclined ultra-thick coal seam gas control method based on a binary composite liquid. The method includes taking a clean fracturing fluid system and a microemulsion as a binary composite liquid. The method includes injecting the binary composite liquid into a coal mass by means of a main hydraulic fracturing and permeability improvement method of hydraulic fracturing and water jet slotting to form a coal mass gas extraction system of binary composite liquid fracturing and permeability improvement. The method includes investigating and analyzing a gas control effect of the steeply-inclined ultra-thick coal seam according to change characteristics and analysis of gas extraction flow rate, change characteristics and analysis of permeability coefficient of coal seam, change characteristics and analysis of gas natural desorption speed of coal mass, change characteristics and analysis of gas concentration of return air flow of working face and theoretical analysis of drilling cuttings index.

Подробнее

Номер записи: 74

20-08-2015 дата публикации

Apparatus and method for measuring surface tension

Номер: US20150233810A1

Автор: Junghoon Lee, Seungyul Choi, Yongjoo Kwon

Принадлежит: SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION

The present invention relates to an apparatus and method for measuring surface tension. More particularly, the present invention relates an apparatus and method for measuring surface tension through an electrical scheme which is simpler and has improved accuracy compared to a conventional optical scheme.

Подробнее

Номер записи: 75

10-08-2017 дата публикации

Methods of determining the properties of a fluid body

Номер: US20170227435A1

Автор: Anthony James Robinson, Samuel Siedel

Принадлежит: College of the Holy and Undivided Trinity of Queen Elizabeth near Dublin

The properties of a fluid body in the form of a surface-attached droplet/bubble can be determined. A data set is stored describing a plurality of droplets/bubbles of different shapes; each shape is captured as a combination of two or more linear dimensional measurements. For each shape the data set includes one or more parameters describing the relationship between the physical properties of a pair of fluids capable of forming that shape as a surface-attached droplet/bubble disposed in a surrounding fluid medium. A fluid body is provided in the form of a surface-attached droplet/bubble and a plurality of linear dimensional measurements are taken and provided as input to a processing apparatus. Processing apparatus determines from the data set the one or more parameters associated with the shape described by said linear dimensional measurements. Particular the surface tension of a fluid can be found in this way based on simple dimensional measurements.

Подробнее

Номер записи: 76

16-08-2018 дата публикации

Method and system for determining dissolution properties of matter

Номер: US20180231446A1

Автор: Sami Svanbäck

Принадлежит: Sami Svanbäck

The invention concerns a method and system for determining dissolution properties of a particle. The method comprises providing into a vessel dissolution medium capable of dissolving the particle and providing the particle into said vessel in contact with the dissolution medium for dissolving the particle. According to the invention, the particle is trapped in a particle trapping zone formed at a predetermined location in the vessel, the particle trapping zone being formed preferably at least partially by continuous hydrodynamic motion of the dissolution medium. Residue of the particle is imaged while being trapped in said particle trapping zone for providing a plurality of sequential images of the particle residue. Finally, at least one dissolution property of the particle is determined based on the sequential images. The invention allows for dissolution rate, intrinsic dissolution rate and/or solubility of matter to be reliably determined from very small sample amounts and without manual affixation of samples.

Подробнее

Номер записи: 77

23-07-2020 дата публикации

HYDROPHOBIC COATING CHARACTERIZATION

Номер: US20200232895A1

Автор: Arunmozhi Ashwin, Herman David Michael, Krishnan Venkatesh, Patil Sunil Reddy

Принадлежит: FORD GLOBAL TECHNOLOGIES, LLC

A system includes a processor and a memory storing instructions executable by the processor to actuate a component upon determining that a hydrophobic coating of a surface is degraded based on a comparison of a characteristic of a liquid droplet with a threshold value. 1. A system , comprising: a processor and a memory storing instructions executable by the processor to actuate a component upon determining that a hydrophobic coating of a surface is degraded based on a comparison of a characteristic of a liquid droplet with a threshold value.2. The system of claim 1 , the instructions further including instructions to compare an amount of distortion of an image reflected by the liquid droplet with a threshold distortion value.3. The system of claim 1 , the instructions further including instructions to determine an object on the surface is the liquid droplet before the comparison of the characteristic of the liquid droplet with the threshold value.4. The system of claim 1 , the instructions further including instructions to actuate a cleaning system to clean the surface before the comparison of the characteristic of the liquid droplet with the threshold value.5. The system of claim 1 , the instructions further including instructions to actuate a cleaning system to provide a specified amount of liquid to the surface before the comparison of the characteristic of the liquid droplet with the threshold value.6. The system of claim 1 , the instructions further including instructions to at least one of transmit a fault code and store the fault code upon determining that the hydrophobic coating of the surface is degraded.7. The system of claim 1 , the instructions further including instructions to increase an interval of actuation for a cleaning system upon determining that the hydrophobic coating of the surface is degraded.8. The system of claim 1 , the instructions further including instructions to compare a contact angle of the liquid droplet with a threshold contact ...

Подробнее

Номер записи: 78

23-07-2020 дата публикации

Dynamic contact angle measurement

Номер: US20200232896A1

Автор: Abdulkareem AlSofi, Amar Alshehri

Принадлежит: Saudi Arabian Oil Co

A contact angle measurement system includes a housing that can hold a volume of a first fluid having a first density, an adjustable rock sample holder positioned within the housing, a fluid dropper attached to the housing, an image capturing a device, and a computer system. The holder can support a rock sample. An orientation of the holder relative to the housing is adjustable such that an outer surface of the rock sample is at a non-zero angle relative to a lower wall of the housing. When the orientation of the holder relative to the housing is such that the outer surface of the rock sample is at the non-zero angle relative to the lower wall, the fluid droplet traverses the outer surface of the rock sample. The image capturing device can capture images of the fluid droplet as the fluid droplet traverses the outer surface of the rock sample.

Подробнее

Номер записи: 79

08-09-2016 дата публикации

Methods and Apparatus to Determine Diffusion Properties of Porous Structures for Drug Delivery

Номер: US20160258855A1

Автор: Barrett Michael S., Campbell Randolph E., Erickson Signe, Farinas Kathleen Cogan, Reich Cary

Принадлежит:

Disclosed herein are improved therapeutic devices and methods and improved porous structures and measurement apparatus for use with therapeutic devices. In many embodiments, a porous structure is measured based on diffusion of the gas through the porous structure. The gas measurement may comprise an amount of gas measured to determine a resistance of the porous structure to diffusion. The diffusion of the gas through the porous structure can be used to determine release of a therapeutic agent through the porous structure, such that targeted amounts of therapeutic agent can be released for extended times and such that therapeutic device reservoir volume and porous frit structure can be tuned to release the therapeutic agent for an extended time above a target amount for the extended time. 164.-. (canceled)65. An apparatus to determine a release rate of a therapeutic agent through a porous structure by measuring diffusion of one or more components of compressible fluids , the apparatus comprising:a support to receive the porous structure having a first side and a second, opposite side, the porous structure affixed to an implantable therapeutic device;a first source of a first fluid;a second source of a second fluid;a first chamber configured to contain the first fluid in fluid communication with the first side of the porous structure at a first pressure; anda second chamber configured to be in fluid communication with the second side of the porous structure at a second pressure,wherein the first pressure substantially equals the second pressure such that diffusion of one or more components of the first and second fluids is driven by a concentration gradient between the first chamber and the second chamber and pressure-driven convective gas flow across the porous structure is substantially inhibited; anda detector in fluid communication with one or both of the first and second chambers, the detector configured to measure an amount of one or more components of the first ...

Подробнее

Номер записи: 80

20-11-2014 дата публикации

Substrate with a Structured Surface and Methods for the Production Thereof, and Methods for Determining the Wetting Properties Thereof

Номер: US20140343687A1

Автор: Jennissen Herbert

Принадлежит:

An implant includes a microstructured hyperhydrophilic surface with protrusions and depressions in which a spacing between the protrusions as a statistical mean is in a range of 1 to 100 μm and a profile height of the protrusions and depressions as a statistical mean is in the range of 1 to 80 μm. 1. A substrate with a microstructured hyperhydrophilic surface with protrusions and depressions , wherein the spacing between the protrusions as the statistical mean is in the range of 1 to 100 μm and the profile height of the protrusions and depressions as the statistical mean (Ra-value) is in the range of 1 to 80 μm , wherein at least one of the two dynamic contact angles (θund θ) is in the hyperhydrophilic range with ΔF/P·γ>1.0 to 2.15 (θ>0 ,0i°−80i°) , in particular with ΔF/P·γ>1.0 to 1.0619 (θ>0 ,0i°−20i°).2. A substrate according to wherein the first microstructure with the first protrusions and depressions is superimposed by a second microstructure with second protrusions and depressions claim 1 , wherein the spacing between the second protrusions as the statistical mean is in the range of 0.1 to 10 μm and the height of the second protrusions and depressions has as the statistical mean (Ra-value) is in the range of 0.1 to 10 μm.3. A substrate according to or wherein the hyperhydrophilic surface is microstructured irregularly or at least in partial regions regularly.4. A substrate according to claim 1 , or wherein the microstructured hyperhydrophilic surfaces are superimposed with a nanostructure which was preferably produced by a wet-chemical procedure by acid etching.5. A substrate according to one of to wherein the substrate is an implant.6. A method for the production of a substrate with a regularly microstructured surface with protrusions and depressions claim 1 , wherein the spacing between the protrusions as the statistical mean is in the range of 1 to 100 μm and the profile height of the protrusions and depressions as the statistical mean (Ra-value) is in the ...

Подробнее

Номер записи: 81

08-08-2019 дата публикации

CONTACT ANGLE MEASUREMENT WITH SONICATION

Номер: US20190242803A1

Автор: AlGeer Mohammed, Alshehri Amar

Принадлежит: Saudi Arabian Oil Company

A contact angle measurement system includes a housing, a rock sample holder positioned within the housing, a fluid dropper attached to the housing, and a sonicator attached to the housing. The holder can support a rock sample whose contact angle is to be measured. The fluid dropper is positioned relative to the holder to drop a fluid droplet on the rock sample when the rock sample is supported by the holder. The housing can transmit the sound wave to the fluid droplet on the rock sample, and the sound wave can sonically remove the fluid droplet from the rock sample. 1. A contact angle measurement system comprising:a housing;a rock sample holder positioned within the housing, the holder configured to support a rock sample whose contact angle is to be measured;a fluid dropper attached to the housing, the fluid dropper positioned relative to the holder to drop a fluid droplet on the rock sample when the rock sample is supported by the holder; anda sonicator attached to the housing, the sonicator configured to generate a sound wave, the housing configured to transmit the sound wave to the fluid droplet on the rock sample, the sound wave configured to sonically remove the fluid droplet from the rock sample.2. The system of claim 1 , wherein the housing comprises an upper wall claim 1 , a lower wall below the upper wall claim 1 , and side walls connecting the upper wall and the lower wall to form an enclosure claim 1 , wherein the holder is attached to the upper wall and positioned within the enclosure.3. The system of claim 2 , further comprising a plurality of clips claim 2 , each attached to the holder claim 2 , the plurality of clips spaced apart from each other by a distance in which the holder is positioned.4. The system of claim 3 , further comprising an adjustable screw attached to one of the plurality of clips claim 3 , the screw configured to change the distance between the plurality of clips.5. The system of claim 4 , wherein the adjustable screw is a first ...

Подробнее

Номер записи: 82

08-08-2019 дата публикации

DYNAMIC CONTACT ANGLE MEASUREMENT

Номер: US20190242804A1

Автор: Alshehri Amar, AlSofi Abdulkareem

Принадлежит: Saudi Arabian Oil Company

A contact angle measurement system includes a housing that can hold a volume of a first fluid having a first density, an adjustable rock sample holder positioned within the housing, a fluid dropper attached to the housing, an image capturing a device, and a computer system. The holder can support a rock sample. An orientation of the holder relative to the housing is adjustable such that an outer surface of the rock sample is at a non-zero angle relative to a lower wall of the housing. When the orientation of the holder relative to the housing is such that the outer surface of the rock sample is at the non-zero angle relative to the lower wall, the fluid droplet traverses the outer surface of the rock sample. The image capturing device can capture images of the fluid droplet as the fluid droplet traverses the outer surface of the rock sample. 1. A contact angle measurement system comprising:a housing configured to hold a volume of a first fluid having a first density, the housing comprising:an upper wall;a lower wall below the upper wall; andside walls connecting the upper wall and the lower wall, the upper wall, the lower wall and the side walls defining an enclosure to hold the volume of the first fluid;an adjustable rock sample holder positioned within the housing, the holder configured to support a rock sample, wherein an orientation of the holder relative to the housing is adjustable such that an outer surface of the rock sample is at a non-zero angle relative to the lower wall of the housing, wherein the holder comprises a stationary plate on a first end of the holder, a moveable plate on a second end of the holder opposite the first end, and a plate-adjusting screw running through the upper wall of the housing and coupled to the moveable plate, the plate-adjusting screw configured to adjust a position of the moveable plate, wherein the upper wall, the lower wall, and the side walls form an enclosure, and the holder is attached to the upper wall;a fluid dropper ...

Подробнее

Номер записи: 83

08-08-2019 дата публикации

RELEASE TEST SYSTEM FOR SIMULATING THE CHANGE IN STATE OF MEDICAL ACTIVE INGREDIENTS

Номер: US20190242863A1

Автор: BAGUHL Romy, BELOW Harald, DEUTER Anne, DOMANSKI Grzegorz, FRONCZYK Olga, Garbacz Grzegorz

Принадлежит: PHYSIOLUTION GMBH

The invention relates to a release test system () for simulating the change in state of medical active ingredients in the region of a human or animal organ, comprising at least: 1. A release test system for simulating the change in state of medical active ingredients in the region of a human or animal organ , comprising at least:a main body of a release test vessel;a lid of the release test vessel;technical control means for influencing simulation conditions prevailing within the release test vessel, wherein the technical control means comprise at least one stirring mechanism and one temperature control device; and furthermorea sampling device;whereinthe lid and at least the stirring mechanism are permanently connected to one another and a nondetachable connection is producible or exists between the main body and the lid.2. The release test system according to claim 1 , whereinthe lid is form-lockingly and/or force-lockingly connectable or connected and/or is materially bondable or bonded to the main body.3. The release test system according to claim 1 ,whereinthe lid is hermetically sealed or sealable relative to the main body.4. The release test system according to claim 1 ,whereinthe stirring mechanism has a drive interface, which is accessible from outside the release test vessel.5. The release test system according claim 1 ,whereinthe sampling device comprises at least one sampling tube or additionally a sample return tube, these each being arrangeable or arranged in a complementary receptacle in the lid.6. The release test system according to claim 1 ,whereinone or more of the following features are incorporated structurally into the stirring mechanism: a feed path for liquid and/or gaseous substances; technical means for measuring pH; technical means for measuring temperature.7. The release test system according to claim 1 ,whereina resilient flask is arranged or arrangeable inside the release test vessel and can be supplied with a pressure medium.8. The ...

Подробнее

Номер записи: 84

07-09-2017 дата публикации

METHOD AND DEVICE FOR DETERMINING THE DISINTEGRATION TIME OF FILM-SHAPED PHARMACEUTICAL DOSAGE FORMS

Номер: US20170254791A1

Автор: Nink Jörg, OBERMÜLLER Katharina, PICHLER Josef, WOTZKO Alexander

Принадлежит:

The present invention relates to a method for determining the disintegration time of a film-shaped pharmaceutical dosage form and a disintegration testing device for use in such a method. 1. A method for determining the disintegration time of a film-shaped pharmaceutical dosage form , the method comprising:(a) placing the film-shaped pharmaceutical dosage form between a bottom side opening of an upper liquid receiving section and a top side opening of a lower liquid receiving section;(b) applying a liquid into the upper liquid receiving section;(c) observing the penetration of the liquid through the film-shaped pharmaceutical dosage form; and(d) determining the time between step (b) and step (c).2. The method according to claim 1 , wherein the liquid is water or an artificial body fluid.3. The method according to claim 1 , wherein the penetration of the liquid through the film-shaped pharmaceutical dosage form is detected by observing the detachment of a first droplet from the film-shaped pharmaceutical dosage form placed between the bottom side opening of the upper liquid receiving section and the top side opening of the lower liquid receiving section.4. The method according to claim 1 , wherein the penetration of the liquid through the film-shaped pharmaceutical dosage form is detected visually or by one or more detecting means selected from the group consisting of a weight change sensor claim 1 , an impact sensor claim 1 , an image recognition sensor claim 1 , a capacitive sensor claim 1 , an electric resistivity sensor claim 1 , a motion sensor claim 1 , a vibration sensor claim 1 , and an acoustic sensor.5. The method according to claim 1 , wherein the time between step (b) and step (c) is measured manually or automatically with a time measurement means.6. The method according to claim 1 , wherein the time between step (b) and step (c) is measured by a time measurement means which is coupledto a liquid delivery means which applies the liquid into the upper ...

Подробнее

Номер записи: 85

13-09-2018 дата публикации

DIFFUSION CELLS AND RELATED METHODS

Номер: US20180259438A1

Автор: Dash Alekha, Munt Daniel

Принадлежит:

A method of performing a diffusion test includes clamping a membrane to a body such that a first surface of the membrane is in fluid communication with an interior chamber of the body and a second surface of the membrane is exposed to ambient air, flowing a substance through the ambient air such that at least a portion of the substance lands on the second surface while the membrane is vertically oriented, and determining a concentration of the substance in the interior chamber after some of the substance has diffused through the membrane. 1. A method of performing a diffusion test , comprising:clamping a membrane to a body such that a first surface of the membrane is in fluid communication with an interior chamber of the body and a second surface of the membrane is exposed to ambient air;flowing a substance through the ambient air such that at least a portion of the substance lands on the second surface while the membrane is vertically oriented; anddetermining a concentration of the substance in the interior chamber after some of the substance has diffused through the membrane.2. The method of claim 1 , further comprising preventing the substance from pooling on the membrane.3. The method of claim 1 , further comprising arranging the body in a horizontal orientation prior to flowing the substance through ambient air.4. The method of claim 1 , further comprising assembling a splash guard with the body to prevent an airborne flow of the substance from contacting the body.5. The method of claim 1 , wherein clamping the membrane to the body comprises providing an air-solid interface.6. The method of claim 1 , wherein flowing the substance through the ambient air comprises evenly distributing the substance across the second surface of the membrane.7. The method of claim 1 , further comprising distributing a volume of about 2 μL/cmto about 20 μL/cmof the substance across the second surface of the membrane.8. The method of claim 1 , further comprising flowing a heat ...

Подробнее

Номер записи: 86

21-09-2017 дата публикации

Process for Evaluating The Catalytic Performance of A Porous Solid

Номер: US20170267934A1

Автор: Dieter Wallenstein, Stefan Brandt

Принадлежит: WR Grace and Co Conn

Process for evaluating the catalytic performance of a porous solid using a vapor diffusion technique, where a probe molecule and a molecule for dead-time determination is injected into a carrier gas that is then contacted with the porous solid in a vessel, where a detector analyzes the peak width and retention time of a probe molecule and the retention time of the molecule for dead-time determination in the gas exiting the vessel.

Подробнее

Номер записи: 87

21-09-2017 дата публикации

IN VITRO METHOD AND APPARATUS FOR ANALYSING THE BEHAVIOUR OF SUBSTANCES IN SIMULATED PHYSIOLOGICAL ENVIRONMENT

Номер: US20170268976A1

Автор: JERE Dhananjay Jagdish, Mahler Hanns-Christian, Patel Sulabh

Принадлежит: Hoffmann-La Roche Inc.

The invention refers to an in vitro method and apparatus for analysing the behaviour of substances in simulated physiological environment. The method comprises the steps of providing a first fluid, a gel matrix and a second fluid, separating the first fluid and the gel matrix by at least one first semi-permeable membrane and separating the gel matrix and the second fluid by at least one second semi-permeable membrane. The method further comprises the steps of injecting a substance into the first fluid, letting the substance migrate from the first fluid through the at least one first semi-permeable membrane, through the gel matrix, through the at least one second semi-permeable membrane and into the second fluid, and determining clearance of the substance from the first fluid.

Подробнее

Номер записи: 88

08-10-2015 дата публикации

FLUIDIC DEVICE

Номер: US20150285724A1

Автор: COHEN SAMUEL, Dobson Christopher, KNOWLES Tuomas, Rajah Luke, White Duncan

Принадлежит:

A method for determining the diffusion of one or more components, the method includes the steps of (i) providing a component fluid flow having one or more components; (ii) providing a blank fluid flow; (iii) bringing the flow (i) into contact with the flow (ii) in a large cross section channel, thereby to generate two laminar flows; (iv) permitting the laminar flows generated in (iii) to flow from the large cross section channel into a small cross section channel; measuring the lateral diffusion of the one or more components from the component flow into the blank fluid flow in the small cross section channel. Also provided is a diffusion method having the steps of measuring the lateral diffusion of the one or more components from the component flow into the blank fluid flow at a plurality of diffusion times. 1. A method for determining the diffusion of one or more components , the method comprising the steps of:(i) providing a component fluid flow comprising one or more components;(ii) providing a blank fluid flow;(iii) bringing the flow (i) into contact with the flow (ii) in a large cross section channel, thereby to generate two laminar flows:(iv) permitting the laminar flows generated in (iii) to flow from the large cross section channel into a small cross section channel;(v) measuring the lateral diffusion of the one or more components from the component flow into the blank fluid flow in the small cross section channel.2. The method according to claim 1 , wherein the component fluid flows comprises two or more components.3. The method according to claim 1 , wherein the maximum width of the large cross section channel is at least 2 times the width of the small cross section channel.4. The method according to claim 3 , wherein the width of the large cross section channel is at least 10 times the width of the small cross section channel.5. The method according to claim 1 , wherein the width of the small cross section channel is in the range 10 to 500 μητι.6. The ...

Подробнее

Номер записи: 89

18-11-2021 дата публикации

CMC-BASED METHOD FOR SURFACTANT CONCENTRATION DETERMINATION

Номер: US20210356373A1

Автор: AlKhateeb Abdulaziz, AlSofi Abdulkareem, Kaidar Ziyad

Принадлежит: Saudi Arabian Oil Company

A method includes determining a critical micelle concentration (C) of a sample with an unknown concentration (C) of a surfactant based on an assumed surfactant concentration (C) of the sample, providing a benchmark solution with a known concentration of the surfactant, determining an actual critical micelle concentration (C) of the surfactant from the benchmark solution, and calculating the unknown concentration (C) of the surfactant in the sample from the following equation: C=C/(C/C). 1. A method , comprising:{'sub': cm assumed', 's', 'assumed, 'determining a critical micelle concentration (C) of a sample with an unknown concentration (C) of a surfactant based on an assumed surfactant concentration (C) of the sample;'}providing a benchmark solution with a known concentration of the surfactant;{'sub': 'cm', 'determining an actual critical micelle concentration (C) of the surfactant from the benchmark solution; and'}{'sub': s', 's', 'cm', 'cm assumed', 'assumed, 'calculating the unknown concentration (C) of the surfactant in the sample from the following equation: C=C/(C/C).'}2. The method according to claim 1 , wherein determining the critical micelle concentration of the sample comprises:adding a known amount of dilution fluid to the sample to dilute the sample;taking a plurality of surface tension measurements of the sample at different dilution intervals;plotting the plurality of surface tension measurements as a function of the dilution; andidentifying the critical micelle concentration at a change in slope along the plot.3. The method according to claim 1 , wherein determining the critical micelle concentration of the sample comprises taking a physical property measurement of the sample at different dilution intervals of the surfactant in the sample.4. The method according to claim 1 , wherein determining the actual critical micelle concentration of the benchmark solution comprises:taking a plurality of surface tension measurements of the benchmark solution at ...

Подробнее

Номер записи: 90

29-08-2019 дата публикации

Apparatus and method for the non-destructive measurement of hydrogen diffusivity

Номер: US20190265220A1

Автор: Abderrazak Traidia, Mohammed Shahrani, Sebastien A. Duval

Принадлежит: Saudi Arabian Oil Co

Apparatuses and methods of measuring a hydrogen diffusivity of a metal structure including during operation of the metal structure, are provided. A hydrogen charging surface is provided at a first location on an external surface of the structure. In addition, a hydrogen oxidation surface is provided at a second location adjacent to the first location on the external surface of the structure. Hydrogen flux is generated and directed into the metal surface at the charging surface. At least a portion of the hydrogen flux generated by the charging surface is diverted back toward the surface. A transient of the diverted hydrogen fluxes measured, and this measurement is used to determine the hydrogen diffusivity of the metal structure in service.

Подробнее

Номер записи: 91

27-09-2018 дата публикации

DIFFUSION CELL AND USES FOR EVALUATING THE DIFFUSION OF A COMPOUND THROUGH A MEMBRANE

Номер: US20180275039A1

Автор: BIANCHI Christophe Jacques Louis, Fredon Laurent, OSMAN-PONCHET Hanan

Принадлежит:

A diffusion cell is described that includes a receiver compartment and a tightening ring intended to be positioned above the receiver compartment in such a way that a membrane sample can be arranged between the receiver compartment and the tightening ring. The cell further includes means for tightening by rotation of the tightening ring on the receiver compartment. Uses of such a diffusion cell, in particular for evaluating the penetration capacity of a compound of interest contained in an aerosol formulation, are also described. These uses can be applicable in an occlusive patch or semi-occlusive patch or in a formulation under occlusive or semi-occlusive conditions in the skin. The uses can also be implemented to evaluate the capacity of an aerosol formulation, an occlusive or semi-occlusive patch or a formulation under occlusive or semi-occlusive conditions to deliver a compound of interest through the skin. 1. A diffusion cell comprising a receptor compartment for containing a receptor medium , a clamping ring to be positioned over the receptor compartment so that a membrane sample can be disposed between the receptor compartment and the clamping ring , and clamping means that operates by rotation of the clamping ring on the receptor compartment , the clamping means comprisingat least two clamping projections inclined on an outer periphery of the receptor compartment; andat least two clamping housings having a shape complementary to the clamping projections, on an outer periphery of the clamping ring, or vice versa,each of the clamping projections being able to be locked into a clamping housing by rotation of the clamping ring relative to the receptor compartment.2. The diffusion cell according to claim 1 , wherein the clamping projections are inclined with a slope ranging from 1 to 45°.3. The diffusion cell according to claim 1 , comprising four inclined clamping projections and four complementary clamping housings regularly distributed on the outer periphery ...

Подробнее

Номер записи: 92

09-12-2021 дата публикации

METHOD OF MEASUREMENT OF INTERFACIAL TENSION (IFT) OF TWO IMMISCIBLE FLUIDS AT RESERVOIR CONDITIONS: AN IN SITU GAS BUFFERED INJECTION

Номер: US20210381352A1

Автор: Al-Saleh Salah Hamad, Al-Yousef Ali Abdullah, Gmira Ahmed

Принадлежит: Saudi Arabian Oil Company

A method for determining interfacial tension of a hydrocarbon in a brine fluid, the method including injecting a first brine fluid into a test cell, the first brine fluid having an initial ionic composition, injecting a hydrocarbon fluid into the test cell, contacting the hydrocarbon fluid with the first brine fluid, forming a droplet, measuring the interfacial tension of the hydrocarbon fluid in contact with the first brine fluid, at least partially displacing the first brine fluid with an inert gas, measuring a ionic composition salinity of the displaced first brine fluid in an ionic chromatograph, and comparing the measured ionic composition salinity to the initial ionic composition. 1. A method for determining interfacial tension of a hydrocarbon in a brine fluid , comprising:injecting a first brine fluid into a test cell, the first brine fluid having an initial ionic composition;injecting a hydrocarbon fluid into the test cell;contacting the hydrocarbon fluid with the first brine fluid, forming a droplet;measuring the interfacial tension of the hydrocarbon fluid in contact with the first brine fluid;at least partially displacing the first brine fluid with an inert gas;measuring a ionic composition of the displaced first brine fluid in an ionic chromatograph; andcomparing the measured ionic composition to the initial ionic composition.2. The method of claim 1 , wherein when the measured ionic composition matches the initial ionic composition claim 1 , the method further comprising:injecting a second brine fluid into the test cell, the second brine fluid having a second initial ionic composition;injecting the hydrocarbon fluid into the test cell;contacting the hydrocarbon fluid with the second brine fluid, forming a droplet;measuring the interfacial tension of the hydrocarbon fluid in contact with the second brine fluid;at least partially displacing the second brine fluid with the inert gas;measuring a ionic composition of the displaced second brine fluid in an ...

Подробнее

Номер записи: 93

05-10-2017 дата публикации

DIFFUSION MONITORING PROTOCOL FOR OPTIMIZED TISSUE FIXATION

Номер: US20170284920A1

Автор: Bauer Daniel, Chafin David, Otter Michael

Принадлежит:

The subject disclosure presents systems and computer-implemented methods for evaluating a tissue sample that has been removed from a subject. A change in speed of the energy traveling through the sample is evaluated to monitor changes in the biological sample during processing. The rate of change in the speed of the energy is correlated with the extent of diffusion. A system for performing the method can include a transmitter that outputs the energy and a receiver configured to detect the transmitted energy. A time-of-flight of acoustic waves and rate of change thereof is monitored to determine an optimal time for soaking the tissue sample in a fixative. 1. A method of fixing tissue sample , said method comprising:(a) immersing an unfixed tissue sample in a volume of a fixative solution at a temperature from 0 to 10° C.; (b1) transmitting an ultrasonic acoustic signal through the tissue sample and detecting the ultrasonic acoustic signal after the ultrasonic signal has passed through the tissue sample;', '(b2) calculating the time of flight (TOF) of the ultrasonic acoustic signal;', '(b3) repeating (b1) and (b2) at a plurality of subsequent time points;', '(b4) calculating a rate of diffusion at least at each of the subsequent time points by analyzing a slope of a curve of the TOFs calculated from the ultrasonic acoustic signals measured at each of the time points;', '(b5) determining when the rate of diffusion falls below a predetermined threshold; and, '(b) monitoring a rate of diffusion of the fixative solution into the tissue sample by(c) after the rate of diffusion falls below the predetermined threshold, allowing the tissue sample to warm to a temperature in the range of 20° C. to 55° C. for a period of time sufficient to permit fixation of the tissue sample.2. The method of claim 1 , wherein (b4) comprises(a) fitting a TOF trace connecting two or more of the TOFs determined from (b1)-(b3) for respective time points to a single exponential curve, and ...

Подробнее

Номер записи: 94

05-10-2017 дата публикации

MEASUREMENT OF PHYSICAL PROPERTIES USING A MOBILE DEVICE

Номер: US20170284921A1

Автор: AMIRFAZLI Alidad

Принадлежит:

Systems, methods, and computer program products for measurement of surface properties using a mobile device are described, the surface properties including interfacial (surface) tension, contact angle (static, advancing, or receding), solid surface energy, and rolling or sliding angle on an inclined surface. The system has a support adapted to receive a mobile device with a camera and a processor. A structure is coupled to the support that is adapted to removably receive measurement components. The measurement components are configurable to place a droplet or a bubble within a field of view of the camera. Software on the mobile device is configured to operate the camera to take an image of the droplet or the bubble within the field of view of the camera, and to determine one or more physical properties of the droplet or the bubble based on an analysis of the image. 1. A system for analyzing one or more physical properties of a droplet or a bubble comprising:a support adapted to receive a mobile device comprising a camera and a processor;a structure removably couplable to the support, the structure adapted to removably receive one or more measurement components, each of the one or more measurement components configurable to place the droplet or the bubble within a field of view of the camera, operate the camera to take an image of the droplet or the bubble within the field of view; and', 'determine one or more physical properties of the droplet or the bubble based on an analysis of the image., 'wherein the processor is configured to'}2. The system of claim 1 , wherein the mobile device comprises a smartphone or a tablet computer.3. The system of claim 1 , wherein the one or more physical properties comprises one or more surface thermodynamic properties.4. The system of claim 1 , wherein at least one of the one or more measurement components comprises a component for supporting a droplet on a horizontal surface claim 1 , a component for supporting a droplet on a ...

Подробнее

Номер записи: 95

04-10-2018 дата публикации

Method for Determining Release Rates of Active Principle Ingredients from at Least One Semisolid Form

Номер: US20180284094A1

Автор: Alain Brzokewicz, Huguet Hélène

Принадлежит: GALDERMA RESEARCH & DEVELOPMENT

The invention relates to a method for determining in vitro release rate of at least one active principle ingredient from at least one semisolid form. 1. A method for determining in vitro release rate of at least one active principle ingredient from at least one semisolid form intended for topical routes of administration to skin or its appendages , using a composite multi-well microtitre plate , wherein each well comprises a donor compartment and a corresponding acceptor compartment adapted to receive the donor compartment , the bottom of the donor compartment is made of a porous membrane , the method comprising:a. placing an aliquot of a semisolid form comprising at least one active principle ingredient in at least one donor compartment of the multi-well microtitre plate;b. placing an initial acceptor medium in the corresponding acceptor compartment(s);c. inserting the donor compartment in the corresponding acceptor compartment, so that the membrane in the bottom of the donor compartment is into contact with the initial acceptor medium;d. collecting at least two successive time intervals a sample of the acceptor medium in the acceptor compartment;e. measuring the release rate of said active principle ingredient in each collected samples.2. The method of claim 1 , wherein the sample semisolid form placed in the donor compartments of the multi-well microtitre plate in step a) is different from a well to another.3. The method of claim 1 , wherein the membrane is a synthetic membrane.4. The method of claim 1 , wherein the membrane is a filter claim 1 , more preferably a microporous filter.5. The method of claim 1 , wherein the nature of the membrane is selected in the group consisting of: Polypropylene claim 1 , Polyethersulfone (PES) claim 1 , hydrophilic or hydrophobic polyvinylidenefluoride (PVDF) claim 1 , Mixed cellulose esters (MCE) claim 1 , hydrophilic or hydrophobic polytetrafluoroethylene claim 1 , nylon claim 1 , polycarbonate (PC) claim 1 , polyesters (PET) ...

Подробнее

Номер записи: 96

11-10-2018 дата публикации

DIFFUSION CELL TESTING METHODS CONTAINING BIPHASIC RECEPTOR FLUIDS

Номер: US20180292376A1

Автор: Krone Kenna, Xu Xiaoyan, Yang Wen, Zhang Jerry Z.

Принадлежит:

An in vitro release testing method and system for testing the ability of formulations to deliver agents across a barrier membrane is disclosed. The method may comprise steps of providing a dosage of a semi-solid formulation containing the bioactive agent, a receptor solution, and a barrier membrane to separate the semi-solid formulation and the receptor solution. The receptor solution may be a biphasic solution or an immiscible solution. The semi-solid formulation may be contacted with one side of the barrier membrane and the receptor solution with the other side of the barrier membrane for a time sufficient to produce penetration of the barrier membrane by the semi-solid formulation. The receptor solution may be sampled and assayed to determine the concentration of the bioactive agent in the receptor solution. 1. In a system for testing a bioactive agent comprising a barrier membrane positioned between a donor formulation and a receptor solution , the receptor solution comprises:an immiscible solution.2. The receptor solution of claim 1 , wherein the immiscible solution comprises at least one hydrophilic solution and at least one hydrophobic solution.3. The receptor solution of claim 2 , wherein the at least one hydrophobic solution is an alcohol with five or more carbons claim 2 , an ester claim 2 , an alkane claim 2 , alkene claim 2 , or a combinations thereof.4. The receptor solution of claim 3 , wherein the alcohol is selected from a group consisting of 1-pentanol claim 3 , 1-hexanol claim 3 , 1-heptanol claim 3 , 1-octanol claim 3 , 1-nonanol claim 3 , 1-decanol claim 3 , 1-undecanol claim 3 , cyclopentanol claim 3 , cyclohexanol claim 3 , 3-pentanol claim 3 , 2-hexanol claim 3 , 3-hexanol claim 3 , 2-heptanol claim 3 , 2-octanol claim 3 , 1 claim 3 ,2-heptanediol claim 3 , 1 claim 3 ,2-octanediol claim 3 , a derivative claim 3 , and combinations thereof.5. The receptor solution of claim 3 , wherein the ester is selected from a group consisting of ethyl ...

Подробнее

Номер записи: 97

19-09-2019 дата публикации

Diffusive gradient in thin-films device and apparatus for developing such a device

Номер: US20190285529A1

Автор: Damien Tournieux, Geraldine Castel

Принадлежит: Institut de Radioprotection et de Surete Nucleaire (IRSN)

The invention relates to a diffusive gradient in thin-films device comprising a casing ( 2 ) comprising a first portion and a second portion defining therebetween a housing ( 3 ) for accommodating at least one component-diffusing layer ( 4 ), said component coming from an environment exterior to the device. According to the invention, the casing includes at least two orifices ( 6, 7 ) ensuring the exposure of the diffusion layer to the exterior of the device. The invention also relates to an apparatus for developing a diffusive gradient in thin-films device comprising such a device.

Подробнее

Номер записи: 98

19-09-2019 дата публикации

RELIABLE DETERMINATION OF CONTACT ANGLE OF SESSILE DROPS

Номер: US20190285530A1

Автор: Behroozi Feredoon, Behroozi Peter

Принадлежит:

Various examples are provided related to determination of contact angle of sessile drops. In one example, a method includes determining a volume of a sessile drop of fluid disposed on a test surface; determining a height of the sessile drop of fluid; and determining a contact angle of the sessile drop of fluid based upon the volume and the height of the sessile drop. In another example, a system includes a volume sensing, a height sensing, and computing that can determine a volume and height of a sessile drop using volume and height data from the sensing, and determine a contact angle of the sessile drop with the volume and the height. The contact angle and surface tension can be determined with at least three of volume, a height, a footprint radius, a radius of maximum horizontal extent, and/or an apex radius of curvature of the drop. 1. A system for determining a contact angle of a sessile drop on a test surface , comprising:a volume sensing device that provides volume data corresponding to the sessile drop on the test surface;a height sensing device that provides height data corresponding to the sessile drop on the test surface; and obtain the volume data from the volume sensing device and the height data from the height sensing device;', 'determine a volume and a height of the sessile drop using the volume data and image data, the height being a distance between the test surface and an apex of the sessile drop; and', 'determine a contact angle of the sessile drop based at least in part upon the volume and the height of the sessile drop., 'a computing device configured to2. The system of claim 1 , wherein the volume sensing device is a precision syringe configured to dispense a defined volume of a fluid on a test surface.3. The system of claim 2 , wherein the volume data comprises the volume of the fluid dispensed by the precision syringe.4. The system of claim 1 , wherein the height sensing device is an image capture device configured to obtain an image of a ...

Подробнее

Номер записи: 99

29-10-2015 дата публикации

ASSESSMENT OF RISK OF HYPERTENSION AND METHODS BASED THEREON

Номер: US20150308939A1

Автор: OBERLEITHNER Hans

Принадлежит:

Provided is a method of analysing whether the blood pressure of a subject is sensitive to sodium intake and/or of assessing the susceptibility of a subject to develop hypertension. In the method erythrocytes of the subject are suspended in two sodium chloride solutions of about physiological osmolality. The sodium chloride concentration of one of the two solutions is at least about 25 mM lower than in the other solution. After allowing the suspended erythrocytes in the two sodium chloride solutions to settle for a period of time sufficient to allow the formation of a supernatant the difference in height of the supernatant between the two sodium chloride solutions is detected. An increased difference in height of the supernatants, relative to a threshold value, indicates that the subject's blood pressure is sensitive to sodium intake and/or that the subject is susceptible to develop hypertension. 1. An in vitro method of analyzing whether the blood pressure of a subject is sensitive to sodium intake , the method comprising:(a) suspending erythrocytes of the subject in one or more pairs of a first solution of about physiological osmolality and a second solution of about physiological osmolality, each first solution and each second solution comprising at least one of sodium chloride and potassium chloride,wherein for each pair of first and second solution the first solution comprises sodium chloride, and the second solution comprises sodium chloride or potassium chloride,wherein a second solution comprising sodium chloride has a sodium chloride concentration that is at least about 25 mM higher than the sodium chloride concentration of the first solution, andwherein a second solution comprising potassium chloride has a concentration of potassium chloride that is of at least essentially about the same value as the concentration of sodium chloride in the first solution;(b) allowing the suspended erythrocytes in the first and in the second solution of at least one pair of ...

Подробнее

Номер записи: 100

Настройки

Небесная энциклопедия

Мониторинг СМИ

Форма поиска