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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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Поддерживает ввод нескольких поисковых фраз (по одной на строку). При поиске обеспечивает поддержку морфологии русского и английского языка
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Применить Всего найдено 615. Отображено 100.
21-03-2013 дата публикации

Waveguide-based optical scanning systems

Номер: US20130071850A1
Автор: Reuven Duer
Принадлежит: PLC Diagnostics Inc

A scanning sensor system, methods of use and kits for detecting a biologically active analyte are provided. The scanning senor system includes a light source, a detector, a substrate comprising a plurality of waveguides and a plurality of optical sensing sites in optical communication with one or more waveguide of the substrate, and at least one adapter configured to couple with the substrate and provide optical communication between the light source, the waveguides of the substrate, and the detector.

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Номер записи: 1
31-10-2013 дата публикации

Measurement devices and methods for measuring analyte concentration incorporating temperature and ph correction

Номер: US20130287631A1
Автор: Matthew A. Romey, Soya Gamsey, Thomas A. Peyser
Принадлежит: GluMetrics Inc

Disclosed herein are methods of estimating an analyte concentration which include generating a signal indicative of the analyte concentration, generating a signal indicative of a temperature, generating a signal indicative of a pH, and transforming the signal indicative of the analyte concentration utilizing an equation of the form of a modified Michaelis-Menten equation depending on Michaelis-Menten parameters, wherein values of the Michaelis-Menten parameters are set based upon data which includes temperature and pH calibration parameters, the signal indicative of a temperature, and the signal indicative of a pH. Also disclosed herein are measurement devices which employ the aforementioned methods.

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Номер записи: 2
21-11-2013 дата публикации

Optical biosensor, bio-sensing system including the same, and method of fabricating the optical biosensor

Номер: US20130309135A1
Автор: Dong-Mo IM, Kyoung-won Na, Sung Dong SUH, Yoon-dong Park
Принадлежит: SAMSUNG ELECTRONICS CO LTD

An optical biosensor including a bio-sensing unit configured to receive an optical signal and generating a sensed optical signal, the wavelength of which varies according to a result of sensing a biomaterial; and a spectrometer including a plurality of ring resonators for dividing the sensed optical signal according to a wavelength and generating a plurality of output optical signals, respectively.

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Номер записи: 3
16-01-2014 дата публикации

Combined Illuminator/Light Collectors For Optical Readers

Номер: US20140016344A1
Автор: James E. Clark
Принадлежит: STEP AHEAD INNOVATIONS Inc

Combined illuminator/light collectors (I/LCs) that provide measurement and/or reference light to a target and collect light from the target. One example of a use for a combined I/LC of the present disclosure is for an optic of an optical reader used to read one or more chemical indicators that undergo physical changes that can be optically detected. The combined I/LC includes a spot lensing designed and configured in conjunction with the target to provide spot illumination on the target from one or more light sources. A light collector collects light from the target resulting from the spot illumination. Some embodiments further include dispersive lensing to direct a portion of the light from each light source away from the spot illumination to keep that light from interfering with the spot illumination.

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Номер записи: 4
01-01-2015 дата публикации

REPLACEMENT INDICATOR, ELASTOMERIC ARTICLES AND METHODS

Номер: US20150000589A1
Автор: Brookes Graham R., Howard Michael C., Moulik Pradipta N., Nieten Jason D.
Принадлежит:

A replacement indicator can be operatively associated with an elastomeric article such that the replacement indicator is visually observable. In some cases, the replacement indicator can be secured on or along the elastomeric article. Gas spring assemblies and pneumatic tires including a replacement indicator, as well as methods of manufacture are also included. 1. A replacement indicator for use in cooperation with an associated elastomeric article , said replacement indicator comprising a material having a visually-observable characteristic that changes from a first condition to a second condition that is different from said first condition upon exposure to a predetermined level of one or more environmental agents with said change from said first condition to said second condition capable of being correlated to a change in a material characteristic of the associated elastomeric article.2. A replacement indicator according to claim 1 , wherein said one or more environmental agents includes ozone (O).3. A replacement indicator according to claim 1 , wherein said one or more environmental agents includes oxygen (O).4. A replacement indicator according to claim 1 , wherein said one or more environmental agents includes heat.5. A replacement indicator according to further comprising an adhesive layer.6. A replacement indicator according to further comprising a protective layer extending across at least a portion of said adhesive layer such that said protective layer can at least partially inhibit inadvertent adhesion of said adhesive layer to an object prior to use.7. A replacement indicator according to claim 1 , further comprising a protective layer extending across at least a portion of said material such that said protective layer can at least partially inhibit exposure of said material to said one or more environmental agents prior to use.8. A replacement indicator according to claim 1 , wherein said first condition of said visually-observable characteristic ...

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Номер записи: 5
06-01-2022 дата публикации

SUBSTRATE-IMMOBILIZED OPTICAL NANOSENSORS

Номер: US20220003682A1
Автор: Gong Xun, SALEM Daniel, Strano Michael
Принадлежит: Massachusetts Institute of Technology

A sensor for detecting an analyte can include a photoluminescent nanostructure embedded in a sensor porous planar substrate. The sensor porous planar substrate can be supported by a substrate porous planar substrate. 1. A sensor for detecting one or more analytes , comprising:a porous planar substrate; andat least one photoluminescent nanostructure on or embedded within the sensor porous planar substrate.2. The sensor of claim 1 , further comprising an analyte-binding compound associated with the photoluminescent nanostructure.3. The sensor of claim 2 , wherein the photoluminescent nanostructure includes a polymer.4. The sensor of claim 3 , wherein the polymer includes a polypeptide claim 3 , a polynucleotide or a polysaccharide.5. The sensor of claim 3 , wherein the polymer is a polynucleotide.6. The sensor of claim 1 , further comprising a plurality of regions on the porous planar substrate claim 1 , at least one of the plurality of regions includes a first region including the at least one photoluminescent nanostructure.7. The sensor of claim 6 , wherein the plurality of regions includes a second region including at least one photoluminescent nanostructure different from the at least one photoluminescent nanostructure.8. The sensor of claim 6 , wherein the plurality of regions includes at least three distinct regions.9. The sensor of claim 1 , wherein the porous planar substrate is a paper claim 1 , nitrocellulose claim 1 , or nylon claim 1 , or combinations thereof.10. A method of making a sensor for detecting one or more analytes claim 1 , comprising:depositing a photoluminescent nanostructure on or within a porous planar substrate.11. The method of claim 10 , further comprising patterning the porous planar substrate to include a plurality of regions claim 10 , at least one region receiving the photoluminescent nanostructure.12. The method of claim 10 , wherein depositing includes placing a liquid including the photoluminescent nanostructure on the porous ...

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Номер записи: 6
03-01-2019 дата публикации

Multi-Parameter Water Analysis System with Analysis Application Updateable via a Cloud-Based Data Resource

Номер: US20190003976A1
Автор: Clark James E.
Принадлежит: STEP AHEAD INNOVATIONS, INC.

Multi-parameter water analysis system with a water parameter sensing device configured to wirelessly provide detector data and a smart phone displayable indicator of water analysis test results that are calculated by an analysis application that is updateable via a cloud-based data resource to account for a manufacturing change in indicator chemistry and/or an improvement in test result display. The water parameter sensing device includes an optical sensing apparatus configured to detect light from each of a plurality of indicators for different parameters when the indicator and a chemical parameter are exposed to each other, a processor to process information of the detected light, and wireless communication circuitry for communicating detector data based on the information about the detected light to a remote device. Social networking of water quality data allows sharing to other users. 1. A multi-parameter water analysis system comprising: an optical sensing apparatus configured to detect light produced by an interaction of a chemical parameter in the water and an indicator when the indicator and the chemical parameter are exposed to each other, the indicator selected by a user, the optical sensing apparatus capable of detecting light from a plurality of different user selectable indicators for different chemical parameters in water;', 'a processor in communication with the optical sensing apparatus for receiving information about the detected light, the processor configured to process information about the detected light for a plurality of different indicators; and', 'a wireless communication circuitry in electrical connectivity with the processor for wirelessly communicating detector data based on the information about the detected light from the water parameter sensing device to a remote device; and, 'a water parameter sensing device includinga mobile smart phone device configured to display test results for the chemical parameter to the user, the test results ...

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Номер записи: 7
03-01-2019 дата публикации

QUANTITATIVE ANALYTE ASSAY DEVICE AND METHOD

Номер: US20190004040A1
Автор: LEE Jin Po
Принадлежит:

The present invention relates to an assay device and a method for using such for the quantitative determination of an analyte, based on a test strip, which contains a porous test membrane allowing for capillary flow of the analyte and complexes of the analyte, a porous upstream membrane in fluid connection with the test membrane and a porous downstream membrane in fluid connection with the test membrane, wherein the test membrane contains a test site having immobilized thereon a ligand capable of reacting with the analyte and binding such to the test site, and two standard band sites having immobilized thereon known high and low concentrations of a calibrator agent capable of reacting with a label conjugate and binding such to the standard sites, wherein the upstream membrane has a site for the application of a sample to be analyzed, and has a site downstream from the sample application site for depositing label conjugates capable of reacting with the analyte and label conjugates capable of reacting with the immobilized calibrator agents in the standard bands to provide a known label response in the standards bands, and the downstream membrane is capable of absorbing said sample and providing the capillary flow for the sample through the upstream and test membrane. 1. An assay device for the quantitative determination of an analyte , comprising a test strip containing a porous test membrane allowing for capillary flow of the analyte and complexes of the analyte , a porous upstream membrane in fluid connection with the test membrane and a porous downstream membrane in fluid connection with the test membrane , (a) said test membrane containing a test site having immobilized thereon a ligand capable of reacting with the analyte and binding such to the test site , and at least two standard band sites having immobilized thereon known high and low concentrations of at least two different calibrator agents capable of reacting with a label conjugated antibody and binding ...

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Номер записи: 8
09-01-2020 дата публикации

Portable and autonomous, iot enabled, optical measurement system

Номер: US20200011797A1
Автор: Ademir F. Silva, Jaione Tirapu Azpiroz, Jeannette M. Garcia, Mathias B. Steiner, Michael Engel, Ricardo L. Ohta, Thomas G. Zimmerman
Принадлежит: International Business Machines Corp

A system is provided for performing metal trace analysis on a liquid sample. A sample holder holds an analysis substrate that includes a reference region and at least one test region. An ultraviolet (UV) light source emits ultraviolet light illuminating the liquid sample. An optical sensor detects radiation emanating from the liquid sample and converting the detected radiation into an electrical signal. A microcontroller processes the electrical signal. An external interface transmits the processed electrical signal to an external device. The analysis substrate is configured for manual movement by a user. A tracking system detects a sample scanning location for the metal trace analysis, and includes a light source, other than the UV light source, and another optical sensor. The other optical sensor detects light emitted by the light source.

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Номер записи: 9
25-01-2018 дата публикации

REACH-EXTENDED TEST STRIP

Номер: US20180024073A1
Автор: SCHORNSTEIN RONALD
Принадлежит:

The present invention is directed to a device that extends the reach of a test strip, and to an analytical method that provides for assembly and use of the device. The inventive device is based on a combination of a test strip and test strip packaging that enables the reach of a test strip to be extended. 1. A device for extending the reach of a test strip , comprisingin an unassembled state, a test strip comprising an elongated support comprising a handle end and at least one reagent-bearing absorptive matrix attached to an opposing end of the support, anda test strip package wherein said test strip is removably contained within said test strip package, and the reagent-bearing end of said support is disposed within an end of said test strip package opposite an end that is devised to be opened for removability of said test strip from said test strip package by said handle end of said support, and wherein an exterior surface of said test strip package comprises an adhesive area, andin an assembled state, when said test strip package is opened and said test strip is removed from said test strip package, comprising said handle end of said support adhered to the exterior surface of the opened test strip package by pressured contact with said adhesive area.2. The device of claim 1 , wherein said elongated test strip has a longitudinal axis and said test strip package likewise is elongated and has a longitudinal axis claim 1 , and in said assembled state claim 1 , the longitudinal axis of said test strip is in an oriented position relative to the longitudinal axis of said test strip package selected from generally in alignment with claim 1 , or at an obtuse angle relative to claim 1 , said longitudinal axis of said test strip package.3. The device of claim 2 , wherein said longitudinal axis of said test strip is generally aligned with said longitudinal axis of said test strip package.4. The device of claim 1 , wherein said test strip package is a foil package claim 1 , ...

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Номер записи: 10
28-01-2021 дата публикации

Active composite materials for micro-fluidic and nano-fluidic devices

Номер: US20210025883A1
Автор: Jayan Ozhi Kandathil, Muthukumaran Packirisamy
Принадлежит: Valorbec Societe En Commandite

Microfluidic devices in applications such as biological and chemical sensing provide high sensitivity and exploit minute amounts of samples and reagents in solutions that are low cost, compact, portable and easily distributed to end-users, etc. Polydimethylsiloxane (PDMS) is a common material for the mechanical structure of the body, micro-channels etc. However, its inert nature and biocompatibility mean that active functionality must be added after the formation of the microfluidic structures and structural elements. It would be beneficial to provide designers of microfluidic devices with the ability to implement active elements for the detection of one or more components within a fluid or arising within a fluid from a reaction upstream using a composite comprising a mechanical component, such as the PDMS, with the active material for the active element of the microfluidic device embedded with the PDMS as a composite.

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Номер записи: 11
02-02-2017 дата публикации

OPTICAL SENSOR ELEMENT

Номер: US20170030875A1
Автор: Ortega Schulte Claudius-Michael, Schoenfuss Dirk
Принадлежит:

The invention relates to an optical sensor element, comprising indicators, selected from luminescence-active means that are of the same type or different, and indicator protectors, and to a sensor, comprising at least one such sensor element, an energy source that excites the luminescence emission of the indicators, and a detector unit, wherein the sensor element or sensor is suitable for detecting molecular oxygen in a gaseous or liquid medium and/or for determining the molecular oxygen content of a gaseous or liquid medium and at least one layer of the sensor element bearing the indicator protectors is designed in such a way that the diffusion rate of the molecular oxygen formed on the indicator protectors by means of the reduction of strong oxidants back into the medium is greater than the diffusion rate of molecular oxygen from the medium in the direction of the at-least-one layer bearing the indicator molecules. 1. An optical sensor element comprising:at least one indicator composed of a luminescence-active agent; andat least one indicator protector selected from (a) reducing agents and/or catalysts for the reduction of strong oxidants, (b) adsorbents for chemisorption or physisorption of strong oxidants, or (c) a combination of (a) and (b),wherein the element has at least two layers, and the at least one indicator and the at least one indicator protector are arranged in different layers of the element, and the element comprises at least one indicator-bearing layer and at least one indicator protector-bearing layer, andwherein the at least one indicator protector is arranged in a layer of the element that faces towards the medium and the at least one indicator is arranged in at least one layer that is mounted facing away from the medium.2. The optical sensor element according to claim 1 , wherein the at least one indicator protector-bearing layer is substantially free of indicators.3. The optical sensor element according to claim 1 , wherein the at least one ...

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Номер записи: 12
17-02-2022 дата публикации

Methods and systems for integrated on-chip single-molecule detection

Номер: US20220050049A1
Автор: David Stern, Elliott SORELLE, Parag Mallick, Pierre Indermuhle, Sujal M. Patel
Принадлежит: Nautilus Biotechnology Inc

The present disclosure provides methods and systems for performing single-molecule detection using fabricated integrated on-chip devices. In an aspect, the present disclosure provides a method for on-chip detection of an array of biological, chemical, or physical entities, comprising: (a) providing an array of light sensing devices; (b) immobilizing the array of biological, chemical, or physical entities on a substrate of the array of light sensing devices; (c) exposing the array of biological, chemical, or physical entities to electromagnetic radiation sufficient to excite the array of biological, chemical, or physical entities, thereby producing an emission signal of the array of biological, chemical, or physical entities; (d) using the array of light sensing devices, acquiring pixel information of the emission signal of the array of biological, chemical, or physical entities without scanning the array of light sensing devices across the array of biological, chemical, or physical entities; and (d) detecting the array of biological, chemical, or physical entities based at least in part on the acquired pixel information.

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Номер записи: 13
31-01-2019 дата публикации

Method of Chemical Sensing Using a Multi-Dimensional Cross-Reactive Array

Номер: US20190033214A1
Автор: Schnee Vincent P.
Принадлежит:

The discrimination ability of a chemical sensing cross-reactive arrays is enhanced by constructing sensing elements in two dimensions, first in the x-y plane of the substrate, second in the z dimension so that the sensors are vertically stacked on top of one another. Stacking sensing elements on top of one another adds to the discrimination ability by enabling the characteristic measurement of how fast target chemicals are passing through the stack of sensors. The new invention also allows the ability to discriminate components in a sample mixture by separating them using their innate difference in diffusional rates. Multi-sensor response patterns at each z level of sensors and time delay information from the sample passing from one level to the next are used to generate the response vector. The response vector is used to identify individual component samples and components in a mixture sample. 1. A multi-dimensional cross-reactive array for chemical sensing , comprising:a sensor substrate having stacks of sensor elements, wherein the sensor elements of a given stack are sequentially stacked such that each stack of sensor elements rises from a respective stack area as a unique sequence of sensor layers perpendicular to the sensor substrate; andan enclosure enclosing the sensor substrate such that a carrier medium carrying a chemical sample can flow across the sequentially laid out stack areas on the sensor substrate from one open end to another open end of the enclosure.2. The multi-dimensional cross-reactive array as recited in claim 1 , wherein a sensor element in a stack is comprised of a composite mix of fluorescent nanocrystals of a respective nanocrystal size and a non-fluorescent polymer chosen from Poly(vinyl stearate) claim 1 , Poly(benzyl methacrylate) claim 1 , Poly(methyl methacrylate) and Poly(ethylene-co-vinyl acetate).3. The multi-dimensional cross-reactive array as recited in claim 1 , wherein a sensor element is comprised of CdSe nanocrystals chosen ...

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Номер записи: 14
18-02-2016 дата публикации

DIAGNOSTIC SYSTEM FOR EXHAUST SYSTEM COMPONENTS

Номер: US20160047751A1
Автор: MARKATOU PENELOPE, Pless Jason, SAPP Darrell Scott
Принадлежит: JOHNSON MATTHEY PUBLIC LIMITED COMPANY

A diagnostic system for an exhaust system of an internal combustion engine is disclosed. The diagnostic system comprises a catalyst component and a marker that undergoes a physical transition above a transition temperature of the marker. A method for determining if a catalyst component in an exhaust system for an internal combustion engine has been exposed to a deactivating temperature is also disclosed. 1. A diagnostic system for an exhaust system of an internal combustion engine , the diagnostic system comprising a catalyst component and a marker that undergoes a physical transition above a transition temperature of the marker.2. The diagnostic system of wherein the marker is a ceramic material comprising one or more compounds selected from the group consisting of boron compounds claim 1 , titanium compounds claim 1 , zinc compounds claim 1 , sodium compounds claim 1 , silicon compounds claim 1 , potassium compounds claim 1 , calcium compounds claim 1 , aluminum compounds claim 1 , chromium compounds claim 1 , cobalt compounds claim 1 , iron compounds claim 1 , nickel compounds claim 1 , copper compounds claim 1 , manganese compounds claim 1 , vanadium compounds claim 1 , magnesium compounds claim 1 , and mixtures thereof.3. The diagnostic system of wherein the ceramic material is a metal carbonate selected from the group consisting of a nickel carbonate claim 2 , a cobalt carbonate claim 2 , a chromium carbonate claim 2 , a manganese carbonate claim 2 , and mixtures thereof.4. The diagnostic system of wherein the marker comprises one or more mixed metal oxides comprising a metal selected from the group consisting of magnesium claim 1 , calcium claim 1 , sodium claim 1 , vanadium claim 1 , molybdenum claim 1 , nickel claim 1 , cobalt claim 1 , lanthanum claim 1 , and mixtures thereof.5. The diagnostic system of wherein the one or more mixed metal oxides are selected from the group consisting of Mg(VO) claim 4 , Ni(VO) claim 4 , Na(VO) claim 4 , and mixtures ...

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Номер записи: 15
22-02-2018 дата публикации

Method and Apparatus for Visually and Electrically Detecting Dissolved Hydrogen Gas in Liquids

Номер: US20180052142A1
Автор: Benson David K., Hoagland William, Smith Rodney D.
Принадлежит:

Element One has developed thin films have the ability to quickly, reliably and cost-effectively detect the presence of dissolved hydrogen in liquids through either a visible color change or a measurable resistance change. Thin film sensors are multi-layer thin film devices incorporating a substrate, an active transition metal oxide layer, a discontinuous catalyst layer, as necessary nn additional protective layer. This invention may be used for early detection of fault conditions in transformer oils allowing low cost tests that can effectively Such thin films can also detect the presence of dissolved hydrogen in aqueous solutions for certain therapeutic heath drinks and other applications. 1. A hydrogen detector apparatus comprising: a strip of material including an electrically insulating substrate; a set of at least two electrically conductive contacts; a thin film of hydrogen sensitive material whose electrical resistance changes in the presence of hydrogen; a discontinuous thin film of a catalyst in contact with the hydrogen sensitive material; and a protective coating over the hydrogen sensitive material and catalyst.2. A hydrogen detector apparatus of claim 1 , wherein the electrically insulating substrate is a ceramic or glass sheet.3. A hydrogen detector apparatus of claim 1 , wherein the electrically insulating substrate is a plastic sheet.4. A hydrogen detector apparatus of claim 1 , wherein the electrically conductive contacts are arranged in an interdigitated array with the hydrogen sensitive material bridging over the array so as to complete an electrical path between the first electrical contact and the second electrical contact.5. A hydrogen detector apparatus of claim 1 , wherein the electrically conductive contacts are made from thin films of gold claim 1 , silver claim 1 , copper or other highly conductive material.6. A hydrogen detector apparatus of claim 1 , wherein the electrically conductive contacts are made of indium-tin oxide claim 1 , ...

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Номер записи: 16
03-03-2016 дата публикации

DETECTING ORGANIC CONTAMINANTS

Номер: US20160061739A1
Автор: Herzog Daniel, THONHAUSER Philip
Принадлежит:

A composition including at least one strong oxidant, a color indicating system, and one or more thickening agents is provided. A method of using the composition on an aqueous basis includes detecting any contaminants on a surface with organic substances by visual control after superficially applying the composition to the surface. The composition is not flowable for a predefined period after the superficial application due to the effect of the thickening agent. The one or more thickening agents are stable in the composition during the predefined period, and are selected from synthetic sheet silicates, pyrogenic silicic acid, fatty alkyl (benzene) sulfates, sulfonates, carboxylates, phosphates and aminoxides and mixtures thereof. A color change in the composition applied to the surface during the predefined period indicates that organic contaminants are present on a portion of the surface. 115-. (canceled)16. A method of using a composition on an aqueous basis comprising a) at least one strong oxidant , b) a color indicating system , and c) one or more thickening agents , the method comprising:superficially applying the composition to a surface with organic substances; anddetecting any contaminants on the surface by visual control after the superficial application,wherein the composition is not flowable for a predefined period after the superficial application due to an effect of the one or more thickening agents,wherein the one or more thickening agents are stable in the composition during the predefined period,wherein the one or more thickening agents are selected from the group consisting of synthetic sheet silicates, pyrogenic silicic acid, fatty alkyl (benzene) sulfates, sulfonates, carboxylates, phosphates and aminoxides and mixtures thereof; andwherein a color change in the composition superficially applied to the surface during the predefined period indicates organic contaminants being present on a portion of the surface.17. The method of claim 16 , wherein ...

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Номер записи: 17
04-03-2021 дата публикации

DEVICE FOR DETECTING AND/OR DETERMINING THE CONCENTRATION OF AN ANALYTE PRESENT IN A TISSUE AND A METHOD AND USE OF THIS DEVICE

Номер: US20210063307A1
Автор: Staniszewska Magdalena, STANISZEWSKI Marcin
Принадлежит:

The device for detecting and/or determining the concentration of an analyte present in a tissue includes a sensor which is an optical fibre interferometer, and one interferometer arm being coated with an immobilised binding agent enabling selective binding of the analyte. The interferometer arm is mounted inside a guide enabling puncturing the tissue and performing an in situ measurement without the necessity to collect or prepare a sample. The guide is provided with a closed guide face, longitudinal perforations on sidewalls enabling the analyte to reach the binding agent, and an opening in the input end of the guide for introducing the interferometer with the arm into the guide. At the input end, the opening is sealed, enabling the isolation of the interior of the guide from the surroundings. The interferometer is mounted in a position in which the interferometer does not touch the inside walls of the guide. 1. A device for detecting and/or determining the concentration of an analyte present in a tissue , comprising:a sensor being comprised of an optical fibre interferometer, having one interferometer arm being coated with an immobilised binding agent so as to enable a selective binding of the analyte present in the tissue;a guide, wherein said interferometer arm is mounted inside a guide so as to enable puncturing the tissue and performing the measurement in situ, without the necessity to collect or prepare the sample,wherein said guide is comprised of a closed guide face, longitudinal perforations on sidewalls enabling the analyte to reach the binding agent and an opening in the input end of the guide for introducing the interferometer into the guide at the input end of the guide, the opening being sealed, enabling the isolation of the interior of the guide from the surroundings, and the interferometer being mounted in a position in which the interferometer does not touch the inside walls of the guide.2. The device according to claim 1 , wherein the ...

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Номер записи: 18
09-03-2017 дата публикации

Waveguide-based optical scanning systems

Номер: US20170067829A1
Автор: Reuven Duer
Принадлежит: Ldip LLC

A scanning sensor system, methods of use and kits for detecting a biologically active analyte are provided. The scanning senor system includes a light source, a detector, a substrate comprising a plurality of waveguides and a plurality of optical sensing sites in optical communication with one or more waveguide of the substrate, and at least one adapter configured to couple with the substrate and provide optical communication between the light source, the waveguides of the substrate, and the detector.

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Номер записи: 19
09-03-2017 дата публикации

METHODS AND DEVICES FOR IMPROVED ACCURACY OF TEST RESULTS

Номер: US20170067832A1
Автор: Ferrara, Frachioni Martin L., JR. Joseph M., Ruiz Erwin
Принадлежит: XEROX CORPORATION

The present disclosure relates to using color calibration to improve and increase the accuracy of interpreting color-sensitive results from test strips made of substrates like paper. This is accomplished via a diagnostic test unit including a substrate, at least one region on the substrate, a reagent placed within the region to react, and a series of color legends on the substrate. Different reagent samples may be placed on the separate regions of a substrate for testing. An imaging device is used to capture the reaction results. More precise readings can be obtained by comparing the reaction results to the color legends to determine the measured property of the analyte. 1. A diagnostic test unit for measuring a property of a bodily fluid , comprising:a substrate;at least one analytical region on the substrate, each analytical region containing a reagent; anda plurality of color legends on the substrate, each color legend comprising a color range corresponding to the colors that can appear when the reagent reacts with an associated analyte.2. The test unit of claim 1 , wherein each analytical region includes a microfluidic structure.3. The test unit of claim 1 , wherein the color legends extend in different directions relative to each other.4. The test unit of claim 1 , wherein there is only one analytical region on the substrate.5. The test unit of claim 1 , wherein a total of four analytical regions are present on the substrate claim 1 , and the four regions are arranged in a rectangle.6. The test unit of claim 1 , wherein the substrate is rectangular claim 1 , a total of four analytical regions are present on the substrate and arranged in a circle claim 1 , and the unit has a total of four color legends claim 1 , wherein the four legends form a perimeter suurounding the four analytical regions.7. The test unit of claim 1 , wherein the substrate is rectangular claim 1 , a total of four analytical regions are present on the substrate and arranged in a rectangle ...

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Номер записи: 20
16-03-2017 дата публикации

Film Sensor

Номер: US20170074850A1
Автор: Anton Sadovoy, Cathleen Teh, Harjinder Singh, Maxim Kiryukhin, Mita Lad, Vladimir Korzh
Принадлежит: Agency for Science Technology and Research Singapore, MASSEY UNIVERSITY

The present disclosure relates to a sensor for indicating food quality comprising a semi-permeable film layer, the semi-permeable film layer comprising at least one integrally formed well having at least one sensing element disposed therein; wherein the well is sealed by a second film layer, the semi-permeable film layer being impermeable to said sensing element but is permeable to at least one analyte detectable by said sensing element.

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Номер записи: 21
18-03-2021 дата публикации

SEMICONDUCTOR MODULE INCLUDING SEMICONDUCTOR PACKAGE AND SEMICONDUCTOR PACKAGE

Номер: US20210080501A1
Автор: KANG DAN-KYU, Lee Sang-Yeol, WON Seyoung
Принадлежит: SAMSUNG ELECTRONICS CO., LTD.

A semiconductor module includes a substrate; a plurality of semiconductor packages provided on the substrate; and an environment information indicator configured to display information related to an environment surrounding the plurality of semiconductor packages. 1. A semiconductor module comprising:a plurality of semiconductor packages provided on a substrate; andan environment information indicator provided on the substrate and configured to collect and display information related to surroundings of the plurality of semiconductor packages.2. The semiconductor module of claim 1 , wherein the information related to the surroundings of the plurality of semiconductor packages comprises:information related to temperature of the surroundings of the plurality of semiconductor packages;information related to humidity of the surroundings of the plurality of semiconductor packages;information related to an X-ray of the surroundings being irradiated to the plurality of semiconductor packages; andinformation related to electrical overstress (EOS) of the surroundings being applied to the plurality of semiconductor packages.3. The semiconductor module of claim 1 , wherein the environment information indicator comprises a plurality of first type indicators configured to display a first type of information related to the surroundings of the plurality of semiconductor packages based on information collected by the plurality of first type indicators.4. The semiconductor module of claim 3 , wherein the plurality of first type indicators comprise a first indicator and a second indicator claim 3 ,wherein the first indicator has a first critical value, the first indicator changing a display color of the first indicator based on a first comparison between the first critical value and the first type of information,wherein the second indicator has a second critical value, the second indicator changing a display color of the second indicator based on a second comparison between the first ...

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Номер записи: 22
24-03-2016 дата публикации

TEST ELEMENTS FOR DETECTING AT LEAST ONE ANALYTE IN A BODY FLUID, AS WELL AS METHODS OF MANUFACTURING THE SAME

Номер: US20160082434A1
Автор: Hiller Bernd, Pachl Rudolf, Pfiffi Daniela, Rieger Ewald, Sternberger Christa
Принадлежит:

Test elements are disclosed for detecting at least one analyte in a body fluid, where the test elements include a housing having at least one base element and at least one cover element. The test elements also include at least one fluid channel formed within the housing, where the fluid channel includes a capillary region and a measurement region. The capillary region and the measurement region have differing aspect ratios. The cover element includes at least one test field having at least one test chemical, where the test chemical is adapted to change at least one optically measurable property in the presence of the analyte. In addition, the cover element is mounted to the base element via at least one adhesive that contacts the test field. 1. A test element for detecting at least one analyte in a body fluid , the test element comprising:a housing having at least one base element and at least one cover element; a capillary region, and', 'a measurement region, wherein the capillary region and the measurement region have differing aspect ratios; and, 'at least one fluid channel formed within the housing, the fluid channel comprising at least two regions having differing depths, wherein the two regions compriseat least one test field comprising at least one test chemical, the at least test field being part of the cover element, wherein the test chemical changes at least one optically measurable property in the presence of the at least one analyte, and wherein the cover element is mounted to the at least one base element by using the at least one adhesive, the at least one adhesive contacting the at least one test field in a manner that the adhesive is interposed in between the at least one test field and the at least one base element, wherein the at least one adhesive fully or partially covers the at least one test field such that the at least one adhesive is in direct contact with a test field surface or a part of the test field surface of the at least one test field ...

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Номер записи: 23
29-03-2018 дата публикации

Semiconductor module including semiconductor package and semiconductor package

Номер: US20180088173A1
Автор: Dan-Kyu Kang, Sang-Yeol Lee, Seyoung WON
Принадлежит: SAMSUNG ELECTRONICS CO LTD

A semiconductor module includes a substrate; a plurality of semiconductor packages provided on the substrate; and an environment information indicator configured to display information related to an environment surrounding the plurality of semiconductor packages.

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Номер записи: 24
01-04-2021 дата публикации

THERMAL HISTORY DETECTION LABEL AND REAGENT KIT

Номер: US20210096114A1
Автор: BANNO Shoichi, HORII Kazuyoshi, ODASHIRO Ken
Принадлежит: SYSMEX CORPORATION

A thermal history detection label for detecting a thermal history over a temperature range to be monitored while suppressing an increase in label size is provided. The thermal history detection label is configured to detect a thermal history by the permeation of a molten permeating material into a permeation body, and the thermal history detection label includes a permeating material that integrally includes a first permeating material having a first melting point and a second permeating material having a second melting point higher than the first melting point, and a permeation body into which the permeating material permeates. 1. A thermal history detection label for detecting a thermal history by a molten permeating material permeating a permeation body , the thermal history detection label comprising:a permeating material integrally including a first permeating material having a first melting point and a second permeating material having a second melting point higher than the first melting point; anda permeation body into which the permeating material permeates.2. The thermal history detection label according to claim 1 , further comprising:a determination portion that is capable of reaching the permeating material by permeation within the permeation body and is capable of making a determination by contact with the reached permeating material.3. The thermal history detection label according to claim 2 , whereinthe first permeating material includes a first oily component which has a first melting point; andthe second permeating material includes a second oily component having a second melting point.4. The thermal history detection label according to claim 2 , whereinthe permeation body is a sheet of paper; andthe permeating material is provided at a position separated from the determination portion along a surface direction of the permeation body.5. The thermal history detection label according to claim 2 , whereinthe permeation body includes a first part ...

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Номер записи: 25
21-04-2016 дата публикации

Fabric-base biochemical detecting device and the fabricating method thereof

Номер: US20160109435A1
Автор: Chao-Min Cheng, Chung-Yao YANG, Jer-Liang Yeh, Szu-Ting Lin
Принадлежит: National Tsing Hua University NTHU

The present invention provides a fabric-base biochemical detecting device and the fabricating method thereof. The device comprises a fabric-base material, a detecting material, and glue. The fabricating method comprises the following steps of: (S 1 ) preparing a fabric-base material, and the basic material is a hydrophobic fabric-base material; (S 2 ) applying a plasma to treat part of the hydrophobic fabric-base material for forming a hydrophilic region on the fabric-base material; (S 3 ) preparing a detecting material to be disposed on the hydrophilic region of the fabric-base material; and (S 4 ) preparing glue for covering the detecting material. The present invention can extend the duration of the detecting material by covering the glue with the detecting material, and have the advantages of simplified manufacture procedure, low cost, and availability of multiple biochemical examinations.

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Номер записи: 26
26-04-2018 дата публикации

METHOD FOR DETERMINING THE TEMPERATURE IN A FLOW CHANNEL OF A GAS TURBINE AND MEASURING DEVICE

Номер: US20180112085A1
Автор: LEHMANN Knut
Принадлежит:

A method for determining temperature in a flow channel of a gas turbine positioned on a testing bench includes: arranging at least one rod-shaped element provided with a thermal paint coating inside the flow channel; operating the gas turbine on the testing bench in a defined operating mode, wherein the thermal paint coating of the at least one rod-shaped element changes its color depending on the temperature that the thermal paint coating is exposed to; detecting the color distribution of the thermal paint coating of the at least one rod-shaped element; and determining the temperature that has been present in the flow channel along the at least one rod-shaped element in the defined operating mode based on the detected color distribution. Another embodiment relates to a measuring device having a rod-shaped element provided with a thermal paint coating. 1. A method for determining the temperature in a flow channel of a gas turbine positioned on a testing bench , wherein the method comprises:arranging at least one rod-shaped element provided with a thermal paint coating inside the flow channel,operating the gas turbine on the testing bench in a defined operating mode, wherein the thermal paint coating of the at least one rod-shaped element changes color depending on the temperature that the thermal paint coating is exposed to,detecting the color distribution of the thermal paint coating of the at least one rod-shaped element, anddetermining the temperature that had been present in the flow channel along the at least one rod-shaped element in the defined operating mode based on the detected color distribution.2. The method according to claim 1 , wherein a rod-shaped element that is provided with a thermal paint coating is arranged in a radially extending manner inside the flow channel claim 1 , and the temperature profile of the flow in the flow channel along the radial direction is detected at a given circumferential position and a given axial position based on the ...

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Номер записи: 27
26-04-2018 дата публикации

DEVICES AND METHODS FOR DETECTING AN EXPLOSIVE SUBSTANCE

Номер: US20180113106A1
Автор: Gorski Bernard
Принадлежит:

A wipe for detecting the presence of an explosive substance is composed of an absorbent or adsorbent substrate and a chemical detection solution impregnated within the substrate. The chemical detection solution includes a redox color indicating agent that is operable to exhibit a color change upon reacting with the explosive substance. 1. A wipe for detecting the presence of an explosive substance , comprising:a fibrous substrate; anda chemical detection solution impregnated into the substrate, the chemical detection solution including a redox color indicating agent that is configured to exhibit a color change when the solution contacts the explosive substance.2. The wipe of wherein the fibrous substrate comprises a plurality of fibers selected from the group consisting of cellulose claim 1 , polyamides claim 1 , polyesters claim 1 , polyethylenes claim 1 , polypropylenes claim 1 , polyacrylics claim 1 , cellulose acetate claim 1 , polylactic acid claim 1 , silk claim 1 , wool claim 1 , glass claim 1 , polyaramids claim 1 , and combinations thereof.3. The wipe of wherein the fibrous substrate is a nonwoven material having multiple layers formed from fibers selected from the group consisting of polyolefin claim 1 , polypropylene claim 1 , polyethylene claim 1 , ethylene copolymers and propylene copolymers.4. The wipe of wherein the fibrous substrate is an absorbent nonwoven material formed from a blend of spunbond fibers.5. The wipe of wherein the blend of spunbond fibers is selected from the group consisting of polypropylene claim 4 , polyester and wood pulp.6. The wipe of wherein the redox color indicating agent is selected from the group consisting of neutral red claim 1 , safranine T claim 1 , safranine O claim 1 , indigo claim 1 , indigo carmine claim 1 , methylene blue claim 1 , thionine claim 1 , thymolindophenol claim 1 , gallocyanine claim 1 , nile blue claim 1 , variamine blue claim 1 , diphenylamine claim 1 , 2 claim 1 ,6-dichlorophenolindophenol claim 1 , ...

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Номер записи: 28
16-04-2020 дата публикации

PORTABLE DEVICE FOR COLORIMETRIC OR FLUOROMETRIC ANALYSIS, AND METHOD OF CONDUCTING COLORIMETRIC OR FLUOROMETRIC ANALYSIS

Номер: US20200116644A1
Автор: Askim Jon R., Suslick Kenneth S.
Принадлежит: The Board of Trustees of the University of Illinois

A portable device for colorimetric or fluorometric analysis comprises a linear array of optically-responsive chemical sensing elements; an image sensor in optical communication with the linear array for determining a spectral response of the optically-responsive chemical sensing elements, where the image sensor comprises at least one light emission source; and electronics connected to the image sensor for analyzing spectral response data. A method of conducting colorimetric or fluorometric analysis comprises exposing a linear array of optically-responsive chemical sensing elements to a fluid comprising an analyte; impinging light on the linear array and detecting a spectral response of the chemical sensing elements; and determining an exposed color of each of the chemical sensing elements. 1. A method of conducting colorimetric or fluorometric analysis , the method comprising:exposing a linear array of optically-responsive chemical sensing elements to a fluid comprising an analyte;impinging light on the linear array and detecting a spectral response of the chemical sensing elements; anddetermining an exposed color of each of the chemical sensing elements.2. The method of claim 1 , further comprising:prior to exposing the linear array to the fluid comprising the analyte, impinging light on the linear array and detecting a spectral response of the chemical sensing elements;determining a pre-exposure color of each of the chemical sensing elements;subtracting the pre-exposure color from the exposed color to determine a changed color of each of the chemical sensing elements; andcreating a difference map showing the changed color of each of the chemical sensing elements.3. The method of claim 1 , wherein impinging light on the linear array and detecting the spectral response comprises activating a color contact image sensor in optical communication with the linear array.4. The method of claim 3 , wherein the color contact image sensor comprises red claim 3 , green and ...

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Номер записи: 29
02-05-2019 дата публикации

PH SENSING BIOFILM

Номер: US20190128815A1
Автор: ALSHATWI ALI ABDULLAH, Athinarayanan Jegan, Subbarayan Periasamy Vaiyapuri
Принадлежит:

The pH sensing biofilms include anthocyanin and a cellulose nanostructure or a cellulose nanocomposite. The cellulose nanostructure can include cellulose nanofibrils. The cellulose nanocomposite can include a composite of cellulose nanofibrils and pectin or a composite of cellulose nanofibrils and alginate. The presence of the anthocyanin in the biofilm allows the biofilm to change color in response to pH changes, thereby allowing the biofilm to be used as an active visual indicator of decay. 16-. (canceled)7. A method of manufacturing a pH sensing biofilm , comprising:{'i': 'Petunia hybrida;', 'extracting anthocyanin from'}{'i': 'Phoenix dactylifera;', 'extracting cellulose nanofibrils from'}mixing the cellulose nanofibrils with the anthocyanin to provide a mixture;sonicating the mixture to provide a sonicated mixture; anddrying the sonicated mixture.8Phoenix dactylifera. The method of further comprising harvesting the in Riyadh claim 7 , Saudi Arabia.9Petunia hybrida. The method of further comprising harvesting the in Riyadh claim 7 , Saudi Arabia.10Petunia hybrida. The method of claim 7 , wherein extracting the anthocyanin comprises extracting anthocyanin from petals.11. The method of claim 10 , wherein the extracting comprises:{'i': 'Petunia hybrida', 'immersing the petals in a mixture of methanol and water at a 70:30 ratio to provide a mixture;'}blending the mixture;sonicating the mixture after blending to provide a sonicated mixture; andfiltering the sonicated mixture to obtain anthocyanin extract.12Phoenix dactylifera. The method of claim 7 , wherein extracting the cellulose nanofibrils comprises extracting cellulose nanofibrils from dried biomass.13Phoenix dactylifera. The method of claim 12 , wherein extracting cellulose nanofibrils from dried biomass comprises:{'i': 'Phoenix dactylifera', 'mixing the dried biomass with sodium hydroxide in a hydrothermal reactor to provide an alkaline mixture;'}washing the alkaline mixture with water to provide a pH ...

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Номер записи: 30
02-05-2019 дата публикации

Rapid pH Measurement

Номер: US20190128816A1
Автор: CHOU Stephen Y., Ding Wei, ZHANG Yuecheng
Принадлежит: Essenlix Corporation

Among other things, certain embodiments of the present disclosure are related to devices and methods of performing biological and chemical assays, such as but not limited to pH measurement of bio/chemical samples. 1. A device for rapid pH measurement , comprising:a first plate, a second plate, spacers and a pH indicator, wherein:(a) the plates are movable relative to each other into different configurations, including an open configuration and a closed configuration;(b) each of the plates has, on its respective inner surface, a sample contact area for contacting a sample;(c) one or both of the plates comprise the spacers, at least one of the spacers is inside the sample contact area, and the spacers have a predetermined substantially uniform height; and(d) one or both of the plates comprise, on the respective inner surface, the pH indicator that, upon contacting the sample, exhibits a color indicative of a pH value of the sample;wherein, in the open configuration, the two plates are partially or entirely separated apart, the spacing between the first plate and the second plate is not regulated by the spacers, and the sample is deposited on one or both of the plates; andwherein in the closed configuration, which is configured after deposition of the sample in the open configuration: at least part of the sample is compressed by the two plates into a layer of uniform thickness, the layer is confined by the inner surfaces of the plates and has its thickness regulated by the spacers and the plates.2. A system for rapid pH measurement , comprising:{'claim-ref': {'@idref': 'CLM-00001', 'claim 1'}, '(a) a device of ; and'}(b) a detector that detects the color of the pH indicator in the layer of uniform thickness.3. A smartphone system for a rapid homogenous assay , comprising:{'claim-ref': {'@idref': 'CLM-00001', 'claim 1'}, '(a) a device of ;'} i. one or a plurality of cameras for detecting and/or imaging the sample; and', 'ii. electronics, signal processors, hardware and ...

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Номер записи: 31
28-05-2015 дата публикации

OPTOCHEMICAL SENSOR

Номер: US20150147231A1
Автор: Ribitsch Volker, Tscherner Martin
Принадлежит:

The invention relates to an optochemical sensor comprising a polymer matrix which is applied to a substrate and which is doped with a luminescent colorant, the emissivity of which can be modified after excitation with electromagnetic radiation by substances to be detected such as gaseous or dissolved O, SO, HO, CO, nitrogen oxides and halogenated hydrocarbons, which polymer matrix forms a sensor layer that is also covered by an optical insulating and protective layer which can be permeated by the substance to be analysed. In the optochemical sensor, the sensor layer is formed from a layer which has an insular sensor element or a plurality of mutually separated sensor elements, the at least one sensor element being covered by a non-doped polymer matrix which chemically corresponds to the polymer matrix of the sensor layer. 1. An optochemical sensor including a polymer matrix applied on a substrate and doped with a luminescent dye whose emissivity upon excitation with electromagnetic radiation by substances to be detected , such as gaseous or dissolved O , SO , HO , CO , nitrogen oxides , halogenated hydrocarbons , is variable , and which forms a sensor layer , which is further covered by a protecting , supporting and/or insulating layer permeable for the substance to be analyzed , wherein the sensor layer is formed by a layer comprising at least one insular sensor element , which at least one insular sensor element is covered by an undoped polymer matrix chemically corresponding to the polymer matrix of the sensor layer , and that a further layer corresponding to the undoped polymer matrix is provided between the substrate and the layer comprising the at least one sensor element.2. The optochemical sensor according to claim 1 , wherein the sensor layer is formed by a layer comprising a plurality of mutually separate sensor elements claim 1 , which sensor elements are covered by an undoped polymer matrix chemically corresponding to the polymer matrix of the sensor ...

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Номер записи: 32
16-05-2019 дата публикации

Polymer matrix composites comprising indicator particles and methods of making the same

Номер: US20190144626A1
Автор: Bharat R. Acharya, Clinton P. Waller, Jr., Derek J. Dehn, Satinder K. Nayar
Принадлежит: 3M Innovative Properties Co

A polymer matrix composite comprising a porous polymeric network; and a plurality of indicator particles distributed within the polymeric network structure; wherein the indicator particles are present in a range from 1 to 99 weight percent, based on the total weight of the indicator particles and the polymer (excluding the solvent); and wherein the polymer matrix composite has a density of at least 0.05 g/cm 3 ; and methods for making the same. The polymer matrix composites are useful, for example, as sensors.

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Номер записи: 33
07-05-2020 дата публикации

Gas Detector Tube Kit and Methods of Reading Gas Detector Tubes

Номер: US20200141876A1
Автор: Truex Bryan I.
Принадлежит: Nextteq LLC

Gas detector tubes kits are described. Gas detector tubes may be used to determine the concentration of target gases and/or interferent gases in a sampled gas either visually or electronically. 1. A gas detector tube kit , comprising:a transparent gas detector tube containing a colorimetric chemical reagent within the transparent gas detector tube, wherein the colorimetric chemical reagent reacts with at least one of a target gas and an interferent to change the color of the colorimetric chemical reagent thereby producing a length of stain within the transparent tube corresponding to a concentration of either the target gas or the interferent gas in a sample;a target gas length-of-stain scale to determine a concentration of the target compound in a sampled gas comprising the target gas for use with the transparent gas detector tube; andan interferent gas length-of-stain scale to determine a concentration of the interferent compound in a sampled gas comprising the interferent gas for use with the transparent gas detector tube.2. The gas detector tube kit of claim 1 , wherein the target gas length-of-stain scale and the interferent gas length-of-stain scale are physical length-of-stain scales for visually determining the concentration of either the target gas or the interferent gas.3. The gas detector tube kit of claim 1 , further comprising a second target gas length-of-stain scale wherein the second target gas length-of-stain scale requires a different sample volume than the target gas length-of-stain scale to determine the concentration of the target gas.4. The gas detector tube kit of claim 1 , further comprising an electronic gas detector tube reader comprising an information storage device claim 1 , wherein the target gas length of stain scale is stored electronically in the information storage device.5. The gas detector tube kit of claim 4 , wherein the interferent gas length of stain scale is stored electronically in the information storage device.6. The gas ...

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Номер записи: 34
17-06-2021 дата публикации

Systems, sensors and methods for determining a concentration of an analyte

Номер: US20210181118A1
Автор: Jiarong Wu, Michael James COLLINS, Mitchell AUSTIN, Xiaoke Yi, YANG Han
Принадлежит: Ausmed Global Ltd

Disclosed herein are systems, sensors and methods for determining a concentration of an analyte in a fluid. The system comprises a sensor configured to generate a differential response to a constant concentration of the analyte; and an acquisition device configured to determine the concentration of the analyte from the differential response. The method comprises exposing the fluid to a sensor which is configured to generate a differential response to a constant concentration of the analyte; and measuring a differential response of the sensor to the analyte.

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Номер записи: 35
22-09-2022 дата публикации

SENSOR ARRAYS WITH NUCLEOPHILIC INDICATORS

Номер: US20220299490A1
Автор: Gratacos Nuria Queralto, LIM Sung Hyun, Maruniak Autumn
Принадлежит:

Sensors arrays that include indicators arranged in a pattern on a substrate. The indicators include nucleophilic indicators. In some examples, the sensor arrays with multiple nucleophilic indicators provide superior detection and identification of microorganisms, cancer biomarkers, formaldehyde, organophosphates, and aldehydes. 118-. (canceled)19. A method for determining if a patient has a malady , the method comprising:providing a sensor array comprising a first indicator and a second indicator deposited on a substrate in a predetermined pattern wherein the first and second indicators are nucleophilic indicators;exposing the sensor array to a sample from a patient;detecting a spectral response after exposing the sensor array to the sample and correlating the spectral response to the presence of a malady.200. The method of claim wherein the malady is cancer.210. The method of claim wherein the malady is colon cancer.220. The method of claim wherein the malady is sepsis.230. The method of claim wherein the sample is the exhaled breath of a patient.240. The method of claim wherein the sample is a urine sample.250. The method of claim wherein exposing the sensor array to a sample from the patient comprises exposing the sensor array to headspace gas of a blood sample. This application is a divisional of U.S. patent application Ser. No. 15/897,403, filed Feb. 15, 2018 which claims priority to and the benefit of U.S. Provisional Patent Application No. 62/459,795, filed Feb. 16, 2017 and entitled “Sensor Arrays with Nucleophilic Indicators,” the contents of which are hereby incorporated by reference in their entirety as if fully set forth herein.This disclosure relates to artificial noses for the detection of analytes.Array-based sensors mimic the mammalian gustatory and olfactory systems to detect and characterize fluidic samples by measuring a unique composite response for each analyte rather than an analyte specific sensor. Such cross-responsive sensor arrays have been ...

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Номер записи: 36
14-06-2018 дата публикации

DEVICE FOR MEASURING ELECTROLYTE IONS USING OPTODES AND USES THEREOF

Номер: US20180164220A1
Автор: Choi Youn-suk, Hahn Young-ki, JEONG Hyo-young, Jung Jae-yeon, LEE Joon-hyung, LEE Soo-suk, Park Jin-Young, Seo Hye-jung
Принадлежит:

Provided is a device for measuring electrolyte ions that is capable of providing a uniform pH environment in the region of an optode, and a method of measuring electrolyte ion concentration using the device. 1. A method of measuring an electrolyte ion concentration comprising: flowing a sample into a device for measuring electrolyte ions; and detecting a reaction between an optode in the device and the sample ,wherein the device for measuring electrolyte ions comprises one or more optodes disposed on a surface of a first substrate facing one or more buffers disposed on a surface of a second substrate, wherein the one or more optodes comprises a polymer; and one or more of the optodes are surrounded by a shielding material which is hydrophobic compared to the optodes;wherein the device comprises one or more spacers between the first substrate and the second substrate; the spacers and the first and second substrates together define a cavity or channel; and the one or more optodes and the one or more buffers are within the cavity or channel,and wherein the one or more optodes each comprise a target ionophore which complexes with the target ion when present, and an indicator ionophore which provides a detectable signal indicating the complexes and the optodes are soluble in organic solvent.2. The method of claim 1 , wherein detecting a reaction between an optode in the device and the sample comprises detecting a color change in the optode.3. The method of claim 1 , wherein the device for measuring electrolyte ions comprises an array of optodes on the surface of the first substrate claim 1 , and an array of buffers on the surface of the second substrate claim 1 , wherein the array of optodes faces the array of buffers.4. The method of claim 1 , wherein the buffer is HEPES buffer claim 1 , MES buffer claim 1 , ADA buffer claim 1 , bis-tris buffer claim 1 , tris buffer claim 1 , formate buffer claim 1 , sodium phosphate buffer claim 1 , citrate buffer claim 1 , MOPS buffer ...

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Номер записи: 37
05-07-2018 дата публикации

Chromatography-aided substance sensing in absorbent hygiene and medical products

Номер: US20180184976A1
Автор: Michael Kuniavsky, Siqi Wang
Принадлежит: Palo Alto Research Center Inc

One embodiment of the present invention provides an apparatus for analyzing a liquid comprising a plurality of different substances. The apparatus includes an absorber that comprises one or more layers of absorbent material for absorbing the liquid and one or more sensors embedded within the one or more layers of absorbent material. The sensors are configured to provide information associated with the different substances included in the absorbed liquid, and a location of a respective sensor is determined based on a corresponding substance detected by the sensor and a diffusion property of the substance.

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Номер записи: 38
20-06-2019 дата публикации

ENVIRONMENTAL SENSOR

Номер: US20190187062A1
Автор: BAKER RIVEST JESSICA LOUIS, Chintapalli Mahati, Cocker Eric, Gibson George A., Iftime Gabriel, Overmeere Quentin Van
Принадлежит:

A sensor has a transparent polymer aerogel, and sensing materials dispersed into the transparent, polymer aerogel, where the sensing materials change color in response to environmental conditions. A method of forming a sensor includes providing a substrate, forming a polymer aerogel layer on the substrate, and infusing the polymer aerogel layer with sensing molecules. 1. A sensor , comprising:a transparent polymer aerogel; andsensing materials dispersed into the transparent, polymer aerogel, where the sensing materials change color in response to environmental conditions.2. The sensor in wherein the environmental conditions comprise a presence of target chemical compounds.3. The sensor of claim 1 , wherein the transparent claim 1 , polymer aerogel has a surface area higher than 100 meters squared per gram.4. The sensor of claim 1 , wherein the transparent claim 1 , polymer aerogel has a surface area in the range of 600 to 1000 meters squared per gram.5. The sensor of claim 1 , wherein the transparent claim 1 , polymer aerogel has a haze of 20 percent or lower.6. The sensor of claim 1 , wherein the polymer aerogel has a light transmittance of 40 percent or higher in the wavelength range of relevance for the sensing material.7. The sensor of claim 1 , wherein the transparent claim 1 , polymer aerogel has a porosity of 20 percent or higher.8. The sensor of claim 2 , wherein the transparent claim 2 , polymer aerogel has a response time of approximately 2 seconds for a target molecule to travel through a 1 millimeter thick layer of the aerogel.9. The sensor of claim 2 , wherein the sensor is capable of detecting a concentration of less than 100 ppm for a target molecule.10. The sensor of claim 2 , wherein the sensing materials comprises a mix of different types of sensing molecules claim 2 , where each type of sensing molecule responds predominantly to a different type of the target molecules.11. The sensor of claim 1 , wherein the sensing material responds to the ...

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Номер записи: 39
22-07-2021 дата публикации

Method for degradation-compensated evaluation of luminescence sensor detection signals, and evaluation apparatus therefor

Номер: US20210223176A1
Автор: Dirk Schönfuss, Valetin VERSCHININ
Принадлежит: Hamilton Bonadus AG

A method is provided for degradation-compensated evaluation of detection signals of a sensor arrangement operating on the principle of luminescence quenching, which arrangement has a luminophore that degrades over time, an excitation radiation source, and at least one optical sensor. The luminophore radiates, in accordance with a response characteristic of the sensor arrangement, in reaction to irradiation with a predefined modulated excitation radiation and as a function of the extent of an interaction of the luminophore with a quencher substance that quenches the luminescence of the luminophore. A response radiation is detected by the at least one optical sensor. The sensor arrangement outputs a detected intensity value representing an intensity of the response radiation and a detected phase value representing a phase difference of the response radiation with respect to the modulation of the excitation radiation. A predetermined calibration value correlation is identified in consideration of the reference response characteristic.

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Номер записи: 40
02-10-2014 дата публикации

Methods for Multiplexing Recombinase Polymerase Amplification

Номер: US20140295436A1
Автор: Colin H. Williams, Niall A. Armes, Olaf Piepenburg
Принадлежит: Alere San Diego Inc

This disclosure provides for methods and reagents for rapid multiplex RPA reactions and improved methods for detection of multiplex RPA reaction products. In addition, the disclosure provides new methods for eliminating carryover contamination between RPA processes.

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Номер записи: 41
27-08-2015 дата публикации

METHOD AND APPARATUS FOR DETERMINING ANALYTE CONCENTRATION BY QUANTIFYING AND INTERPRETING COLOR INFORMATION CAPTURED IN A CONTINUOUS OR PERIODIC MANNER

Номер: US20150241358A1
Автор: Burg Bernard, De Brouwer Walter, Zizi Martin
Принадлежит:

In one embodiment, an apparatus for automatic test diagnosis of a test paddle is disclosed. The apparatus comprises a personal computing device including: a camera to capture images over time of test pads of a test paddle, a processor coupled to the camera, and a display device coupled to the processor. The processor analyzes the color changes over time of each test pad to determine a color trajectory over time for each test pad. The processor compares the color evolution trajectory for each test pad with color calibration curves for each test pad to determine an analyte concentration of a test biological sample, such as urine. During the analysis by the processor, the display device displays a user interface with results of the analyte concentration in response to the analysis over time. 1. A method comprising:applying a biological sample to a plurality of test pads of a test paddle;capturing images over periods of time of the plurality of test pads of the test paddle as different reagents of the test pads react to the biological sample;quantifying each color of the plurality of test pads in each of the captured images over time;determining a color trajectory over time for each test pad of the plurality of test pads;comparing the color trajectory with calibration curves to determine analyte concentration for one or more of the plurality of test pads; anddisplaying results of the analyte concentration to a user in response to the comparison.2. The method of claim 1 , further comprising:determining temperature and acidity (pH) of a chemical reaction between the biological sample and a test pad.3. The method of claim 2 , further comprising:before determining the color trajectory, correcting the calibration curves to account for effects of one or more of a reaction time, a temperature, and the acidity (pH).4. The method of claim 1 , whereinthe biological sample is urine or blood.5. An apparatus for automatic test diagnosis of a biological sample with a test paddle ...

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Номер записи: 42
16-07-2020 дата публикации

SYSTEM AND METHOD FOR ESTIMATING A REMAINING LIFETIME OF AN ALDEHYDE FILTER

Номер: US20200225157A1
Автор: Chen Shuang, KONG Tao
Принадлежит:

A system is for estimating a remaining lifetime of an aldehyde filter. The system comprises aa aldehyde filter () through which at least a portion of the gas is to be passed for removing aldehyde () from the gas () and a detecting medium () through which at least a portion of the gas is to be passed comprising photoluminescent carbon-based dots (), a light source for emitting an excitation light (E) through the detecting medium for exciting the carbon-based dots which thereby emit luminescent light (L), a detector () for detecting the luminescent light (L), the luminescent light (L) having a luminescence property; and a controller () for determining information relating to intensity of a red, a green or a blue component of the luminescence property and estimating a remaining lifetime of the aldehyde filter from the determined information. 1. A system for estimating a remaining lifetime of an aldehyde filter , comprising:an aldehyde filter through which at least a portion of the gas is to be passed for removing aldehyde from a gas;a detecting medium through which at least a portion of the gas is to be passed comprising photoluminescent carbon-based dots;a light source for emitting an excitation light through the detecting medium for exciting the carbon-based dots which thereby emit luminescent light, wherein the emitted luminescent light from the carbon-based dots comprises luminescent properties which change when they are contacted with an aldehyde, wherein the extent of the change is dependent on the amount of an aldehyde that has been adsorbed by the detecting medium;a detector for detecting the luminescent light; anda controller for determining information relating to the luminescence property and estimating a remaining lifetime of the aldehyde filter from the determined information.2. The system according to claim 1 , wherein the gaseous aldehyde is one or more of formaldehyde claim 1 , acetaldehyde claim 1 , propionaldehyde claim 1 , benzaldehyde and ...

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Номер записи: 43
24-08-2017 дата публикации

TEST STRIP HOLDING DEVICE FOR LIQUID ANALYSIS

Номер: US20170239664A1
Автор: Alderete John Paul, Eisele Robert Francis
Принадлежит: Flora Bioscience, Inc.

A test strip holder may include an upper body, a lower body, and a mating portion. The upper body may include a first recess. The lower body may include a second recess. The mating portion may fixedly mate the upper body and the lower body. The first recess and the second recess form an internal volume when the upper body and lower body are mated. 1. A test strip holder , comprising:an upper body comprising a first recess;a lower body comprising a second recess; anda mating portion configured to fixedly mate the upper body and the lower body,wherein the first recess and the second recess form an internal volume when the upper body and lower body are mated.2. The test strip holder of claim 1 , wherein the upper body further comprises:a first plurality of pressure points configured to directly contact a first surface of a test strip.3. The test strip holder of claim 2 , wherein the lower body further comprises:a second plurality of pressure points configured to directly contact a second surface of the test strip.4. The test strip holder of claim 3 , wherein each pressure point of the first plurality of pressure points is disposed at a different location along a length of the test strip holder than each pressure point of the second plurality of pressure points.5. The test strip holder of claim 1 , wherein the upper body further comprises:a first compression point disposed at a first location along a length of the upper body that corresponds to a location of a critical interface of the test strip.6. The test strip holder of claim 5 , wherein the upper body further comprises:a second compression point disposed at a second location along the length of the upper body.7. The test strip holder of claim 6 , wherein the first compression point extends into the first recess a first distance claim 6 , wherein the second compression point extends into the first recess a second distance claim 6 , wherein the first distance is larger than the second distance.8. The test strip ...

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Номер записи: 44
09-09-2021 дата публикации

DEVICES AND METHOS FOR DETECTING OR MONITORING THE QUALITY OF FOOD PRODUCTS

Номер: US20210279857A1
Автор: BAO Hanxi, LAN Guanghui, MOSES Karyn E., Tong Zhaohui
Принадлежит:

Described herein are devices for determining or monitoring the quality of a food product. In one aspect, the devices comprise a pH-sensitive film incorporated within a quick response code, wherein the pH-sensitive film is positioned to be in contact with the food product. The pH-sensitive film produces different colors subject to changes in pH of the food product. The color produced by the pH-sensitive film can then be correlated to the quality of the food product. The quick response code can provide additional information regarding the food product. 1. A device for determining or monitoring the quality of a food product , the device comprising a pH-sensitive film incorporated within a quick response code , wherein the pH-sensitive film is positioned to be in contact with the food product , and the device further comprises at least two different color standards.2. The device of claim 1 , wherein the pH-sensitive film incorporated is positioned at the center of the quick response code.3. The device of claim 1 , wherein the device comprises at least three different color standards.4. The device of claim 1 , wherein the standard colors comprise blue claim 1 , yellow claim 1 , and red.5. The device claim 1 , wherein the standard colors are separately positioned in a corner of the device.6. The device claim 1 , wherein the quick response code provides information about the food product comprising the name of the food product claim 1 , date of production claim 1 , date of packaging claim 1 , identity of manufacturer claim 1 , expiration date claim 1 , pH claim 1 , microbial count claim 1 , shelf life claim 1 , spoilage score claim 1 , organic acid type and level pH claim 1 , and any combination thereof.7. The device claim 1 , wherein the pH-sensitive film comprises nanoparticles comprising:a hydrophobic core comprising a hydrophobic dye; anda copolymer of a hydrophobic polymer repeat unit and a pH responsive dendrimer repeat unit.8. The device of claim 7 , wherein the ...

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Номер записи: 45
08-08-2019 дата публикации

MULTI-FLUID TEST STRIP

Номер: US20190242828A1
Автор: Petty Jon A.
Принадлежит:

A multi-fluid test strip may include a first zone to test a first fluid, a second zone to test a second fluid, and a third zone intermediate the first zone and the second zone. The third zone may prevent cross-contamination of the first fluid with the second zone and prevent cross-contamination of the second fluid with the first zone. The multi-fluid test strip may also include a first grip zone and a second grip zone. The first zone may be intermediate the first grip zone and the third zone and the second zone may be intermediate the second grip zone and the third zone. The first grip and second grip zones may be dimensioned to permit gripping of the first and second grip zones without touching the first or second zones. 1. A multi-fluid test strip comprising:a first zone configured to test a first fluid;a second zone configured to test a second fluid; anda third zone configured to prevent cross-contamination of the first fluid with the second zone and the second fluid with the first zone, the third zone intermediate the first zone and the second zone.2. The multi-fluid test strip of claim 1 , further comprising a first grip zone and a second grip zone claim 1 , the first zone intermediate the first grip zone and the third zone and the second zone intermediate the second grip zone and the third zone claim 1 , wherein the first grip zone is dimensioned to permit gripping of the first grip zone without touching the first zone and the second grip zone is dimensioned to permit gripping of the second grip zone without touching the second zone.3. The multi-fluid test strip of claim 2 , wherein the first zone comprises a first test pad configured to test a first aspect of the first fluid and the second zone comprises a second test pad configured to test a second aspect of the second fluid.4. The multi-fluid test strip of claim 3 , wherein the second zone further comprises a third test pad configured to test a third aspect of the second fluid claim 3 , wherein the second ...

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Номер записи: 46
24-09-2015 дата публикации

Multi-Analyte Optical Sensor

Номер: US20150268162A1
Автор: Erickson Timothy A., Lear Kevin L.
Принадлежит: COLORADO STATE UNIVERSITY RESEARCH FOUNDATION

An analyte-detection system has an optical waveguide with first and second cladding layers adjacent a core; a light source coupled to provide light to the waveguide; a photodetector such as a metal-semiconductor-metal, vertical PIN, or horizontal PIN photodetectors, the photodetector having an absorber configured to detect light escaping from the waveguide through the first cladding layer; multiple, separate, photocurrent collectors, where each photocurrent collector collects current from a separate portion of the photodetector absorber; and at least one current-sensing amplifier for receiving photocurrent. The photodetector absorber is an undivided absorber region for multiple photocurrent collectors. Either separate amplifiers are provided for each of the multiple photocurrent collection lines, or multiplexing logic couples selected photocurrent collectors to amplifiers, while coupling unselected photocurrent collectors to a bias generator. 1. An improved detection system of the type comprising:an optical waveguide having first and second cladding layers adjacent to a core, the core transparent at a first wavelength;a light source coupled to provide light of the first wavelength to the waveguide;a photodetector having an absorber disposed near the first cladding layer and configured to detect light escaping from the waveguide at the first wavelength;a plurality of separate photocurrent collection lines, where each photocurrent collection line is configured to collect current from a different portion of the photodetector absorber; andat least one amplifier for receiving photocurrent;the improvement comprising the photodetector absorber being an undivided absorber region for a plurality of the photocurrent collection lines.2. The detection system of wherein the second cladding layer has at least a sensing portion configured to respond to presence of an analyte with a shift of refractive index claim 1 , the portion configured to respond to an analyte comprising a ...

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Номер записи: 47
21-10-2021 дата публикации

System for Indicating Content within a Fluid Container

Номер: US20210325361A1
Автор: French Adam Everett
Принадлежит:

A system for indicating content within a fluid container provides an improved fuel container for mixed fuel, which indicates its contents to a user. The system communicates whether there is oil, gas, a mixture of the two, or nothing inside the container. When the system is filled with gas only, the color of the can will change to, or otherwise remain, a first color. Similarly, oil alone would be indicated by a unique color. When a user combines oil and gas, the system changes to a new color to let the user know that oil is indeed inside the receptacle of the apparatus. Alternatively, the system may provide a nozzle equipped with the same color-indicating capabilities as the fuel receptacle embodiment. For example, when oil is mixed with gas inside the system, the nozzle may turn blue to ensure that a user is aware of the change of contents. 1. A system for indicating content within a fluid container comprising:a light-permeable hollow body;a chromatic indicator;the light-permeable hollow body comprising an outer body surface and an inner body surface;the chromatic indicator being superimposed across the inner body surface;the chromatic indicator being configured to change to a first opaque color while in physical contact with a quantity of gasoline; andthe chromatic indicator being further configured to change to a second opaque color while in physical contact with a quantity of oil.2. The system for indicating content within a fluid container as claimed in claim 1 , wherein the light-permeable hollow body is made of a translucent material.3. The system for indicating content within a fluid container as claimed in claim 1 , wherein the light-permeable hollow body is made of a transparent material.4. The system for indicating content within a fluid container as claimed in claim 1 , wherein the chromatic indicator is compositionally configured to trigger a first non-volatile chemical reaction between the chromatic indicator and the quantity of gasoline claim 1 , and ...

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Номер записи: 48
01-10-2015 дата публикации

Device for use in the detection of binding affinities

Номер: US20150276612A1
Автор: Christof Fattinger
Принадлежит: Hoffmann La Roche Inc

A device for use in the detection of binding affinities, the device comprising a planar waveguide ( 2 ) arranged on a substrate ( 3 ), and further comprising an optical coupler ( 41 ) having a predetermined length for coupling coherent light ( 1 ) of a predetermined wavelength into the planar waveguide ( 2 ) such that a parallel beam of coherent light propagates through the planar waveguide ( 2 ) with an evanescent field ( 11 ) of the coherent light propagating along an outer surface ( 21 ) of the planar waveguide ( 2 ). The outer surface ( 21 ) of the planar waveguide ( 2 ) comprises binding sites thereon capable of binding target samples to the binding sites such that light of the evanescent field ( 11 ) is diffracted by target samples bound to the binding sites. The binding sites are arranged along a plurality of predetermined straight lines ( 7 ) running parallel to one another with a constant distance between adjacent straight lines. The predetermined straight lines ( 7 ) are arranged at an angle relative to the direction of propagation of the evanescent field ( 11 ) such that the coherent light ( 12 ) diffracted by the target samples bound to the binding sites impinges under a diffraction angle relative to the straight lines onto a further optical coupler ( 8 ) arranged in a portion ( 10 ) of the planar waveguide ( 2 ) outside the beam of coherent light propagating through the planar waveguide. The further optical coupler ( 8 ) couples the diffracted coherent light ( 13 ) out of the planar waveguide ( 2 ) such as to interfere at a predetermined detection location ( 9 ) with a difference in optical path length which is an integer multiple of the predetermined wavelength.

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Номер записи: 49
20-09-2018 дата публикации

METHOD AND SYSTEM FOR MEASURING A SENSOR

Номер: US20180266964A1
Автор: De Boer Bart Michiel, Harmsma Peter Johan, van Neer Paul Louis Maria Joseph
Принадлежит:

The present disclosure concerns a method and apparatus for measuring a sensor () comprising multiple optical resonators () optically connected to a single optical output interface (). The optical resonators () are interrogated with a light input signal (Si). A light output signal (So) is measured from the optic al output interface () to determine a combined spectral response (Sa) covering a wavelength range (W) including a plurality of resonance peaks (λ) for each of the optical resonators (). A Fourier transform spectrum (FT) of the combined spectral response (Sa) is calculated and a harmonic series of periodic peaks (n·f) is identified in the Fourier transform spectrum (FT). The harmonic series of periodic peaks is filtered to obtain a filtered Fourier transform spectrum (FT) and a sensor signal is calculated (X) based on the filtered Fourier transform spectrum (FT). 1. A method for measuring a sensor comprising multiple optical resonators optically connected to a single optical output interface ,wherein each optical resonator has a spectral response comprising a series of resonance peaks at distinct wavelengths,wherein the wavelengths of the resonance peaks are indicative of a sensor measurable, andwherein the method comprises:interrogating the optical resonators with a light input signal;determining, by measuring a light output signal from the optical output interface, a combined spectral response covering a wavelength range including a plurality of the resonance peaks for each of the optical resonators;calculating a Fourier transform spectrum of the combined spectral response;identifying a harmonic series of periodic peaks in the Fourier transform spectrum;filtering the harmonic series of periodic peaks to obtain a filtered Fourier transform spectrum;calculating a sensor signal based on the filtered Fourier transform spectrum.2. The method according to claim 1 , wherein the distinct wavelengths of the resonance peaks are determined by distinct optical path ...

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Номер записи: 50
13-08-2020 дата публикации

DETECTION SYSTEM FOR AN ELECTRONIC NOSE AND AN ELECTRONIC NOSE COMPRISING SUCH A SYSTEM

Номер: US20200256793A1
Автор: BRENET Sophie, HERRIER Cyril, Hou-Broutin Yanxia, Livache Thierry, ROUSSELLE Tristan
Принадлежит:

The invention relates to a detection system for an electronic nose capable of detecting and identifying a set of compounds that can be found in a gaseous sample, which detection system comprises a plurality of cross-reactivity detection sensors (D D D D D D D) for supplying signals representing the presence of one or more compounds of said set in the gaseous sample, and which is particularly characterised in that it further comprises at least one reference sensor (RI) for supplying a signal representing the measurement noise of the detection system. It further relates to an electronic nose comprising such a detection system. 2. The detection system as claimed in claim 1 , wherein the surface of the substrate is a passivated surface.3. The detection system as claimed in claim 2 , wherein the surface of the substrate is passivated with a fluorinated compound selected from compounds comprising at least one perfluorinated terminal alkyl group or fluorinated polymers.4. The detection system as claimed in claim 1 , wherein the fluorinated compound is selected from compounds of formula CFin which v is an integer ranging from 4 to 20 claim 1 , or compounds of formula CF-(L)-Z in which w is an integer ranging from 1 to 12 claim 1 , x is 0 or 1 claim 1 , L represents a divalent spacer group while Z represents a group capable of allowing the compound to be attached to the surface of the substrate claim 1 , preferably a thiol claim 1 , amine claim 1 , silanol claim 1 , carbonyl or carboxyl group.5. The detection system as claimed in claim 4 , wherein the divalent spacer group is a linear or branched claim 4 , saturated or unsaturated hydrocarbon group comprising from 1 to 20 carbon atoms and optionally one or more heteroatoms.6. The detection system as claimed in claim 5 , wherein the divalent spacer group is a divalent alkylene group comprising from 1 to 20 carbon atoms.7. The detection system as claimed in claim 4 , wherein the fluorinated compound is a perfluoroalkanethiol ...

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Номер записи: 51
08-10-2015 дата публикации

TEST WAND FOR LIQUIDS

Номер: US20150285778A1
Автор: Hertel Matthew P., Morris David A.N.
Принадлежит:

A species test wand for liquids, wherein a user is informed whether the concentration of a species is high, at an acceptable level, or low by a comparison of the color of the wand after exposure to the liquid with nearby labeled colored boxes integral with the wand, is described. Tests include liquid evaluation for chlorine, pH and total alkalinity, as examples. 1. A test wand for determination of species concentration in a liquid , comprising:a substrate;at least one band having a species-specific test composition thereon effective for exhibiting a particular color in the presence of a specific species concentration range and mounted on said substrate; andat least one labeled color comparison box corresponding to each of said at least one test band integrated onto said substrate and disposed in the vicinity of said at least one test band such that the color of said at least one test band is readily compared with the color of the at least one comparison box;whereby, color is produced on said at least one test band when said wand is immersed in said liquid.2. The test wand of claim 1 , wherein said at least one test band is mounted using an adhesive.3. The test wand of claim 1 , wherein said substrate comprises polystyrene.4. The test wand of claim 1 , wherein said tests are chosen from chlorine claim 1 , pH and total alkalinity.5. The test wand of claim 1 , wherein said at least one color comparison box comprises boxes labeled as high claim 1 , acceptable and low for said species.6. The test wand of claim 1 , wherein said wand is elongated.7. The test wand of claim 6 , wherein said at least one test band comprises multiple bands having the same composition disposed along the long dimension of said substrate claim 6 , such that several liquid tests are conducted with said wand.8. The test wand of claim 1 , wherein said liquid comprises liquid from a pool or a spa. The present application claims the benefit of U.S. Provisional Patent Application No. 61/724,822 for “ ...

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Номер записи: 52
27-09-2018 дата публикации

Portable and autonomous, iot enabled, optical measurement system

Номер: US20180275056A1
Автор: Ademir F. Silva, Jaione Tirapu Azpiroz, Jeannette M. Garcia, Mathias B. Steiner, Michael Engel, Ricardo L. Ohta, Thomas G. Zimmerman
Принадлежит: International Business Machines Corp

A portable optical measurement system is provided for performing metal trace analysis on a liquid sample. The system includes a sample holder for holding an analysis substrate that includes the liquid sample during the metal trace analysis. The system further includes an ultraviolet (UV) light source for emitting ultraviolet light illuminating the liquid sample. The system also includes an optical sensor for detecting radiation emanating from the liquid sample and converting the detected radiation into an electrical signal. The system additionally includes a microcontroller for processing the electrical signal. The system further includes an external interface for transmitting the processed electrical signal to an external device.

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Номер записи: 53
15-10-2015 дата публикации

Adjustable Colorimetric Moisture Indicators

Номер: US20150293028A1
Автор: Hajime Evan Koon Lun Yuuji, Kang Myungchan
Принадлежит: 3M INNOVATIVE PROPERTIES COMPANY

Compositions are provided comprising: 1) a solid metal oxide support having surface hydroxyl groups; 2) a silyl-containing compound bound to the solid metal oxide support through a silanol bond with the surface hydroxyl groups; and 3) a bis(glyoxime)-transition metal complex bound to the solid metal oxide support. These compositions can be used to make a colorimetric relative humidity-indicating sensor. A method of adjusting the colorimetric response of a moisture-indicating composition and a method of detecting moisture are also provided. 1. A composition comprising:a solid metal oxide support having surface hydroxyl groups;a silyl-containing compound bound to the solid metal oxide support through a silanol bond with the surface hydroxyl groups; anda bis(glyoxine)-transition metal complex bound to the solid metal oxide support.45-. (canceled)6. The composition of claim 1 , wherein the silyl-containing compound is selected from the group consisting of diethoxydimethylsilane claim 1 , hexanethyldisilazane claim 1 , n-octadecyltrichlorosilane claim 1 , 1H claim 1 ,1H claim 1 ,2H claim 1 ,2H-perfluoroctyldimethylchlorosilane claim 1 , and (3-aminopropyl)triethoxysilane.7. The composition of claim 1 , wherein no more than about 50% of surface hydroxyl groups of the support are bound to the silyl-containing compound.8. The composition of claim 1 , wherein the solid metal oxide support comprises an oxide of aluminum claim 1 , silicon claim 1 , or a combination thereof.9. The composition of claim 1 , wherein the transition metal in the bis(glyoxime)-transition metal complex comprises rhodium claim 1 , iridium claim 1 , platinum claim 1 , palladium claim 1 , gold claim 1 , nickel claim 1 , copper claim 1 , or a combination thereof.10. The composition of claim 1 , wherein the bis(glyoxime)-transition metal complex comprises bis(dimethylglyoximato)-nickel(II).11. The composition of claim 1 , wherein the composition quantitatively changes optical spectrum at relative ...

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Номер записи: 54
23-12-2021 дата публикации

CONTRAST COMPONENT COATING FOR SENSOR ANALYSIS

Номер: US20210396133A1
Автор: Gascooke Darren George, Jones Christopher Michael, Li Jian, PRICE James M., Soltmann William J.
Принадлежит:

A contrast device for analysis of a wellbore fluid includes: a substrate; and a contrast agent adhered to the substrate, wherein the contrast agent is configured to respond to an analyte within the wellbore fluid thereby altering a measurable characteristic of the contrast agent. A system including the contrast device may further include an energy source and a detector to facilitate measuring the characteristic of the contrast agent. 1. A contrast device for analysis of a wellbore fluid , the device comprising:a substrate; anda contrast agent adhered to the substrate, wherein the contrast agent is configured to respond to an analyte within the wellbore fluid thereby altering a measurable characteristic of the contrast agent.2. The device according to claim 1 , wherein the substrate comprises a crosslinked silicone and/or a crosslinked silane.3. The device according to claim 1 , further comprising a support claim 1 , wherein the substrate is adhered to the support.4. The device according to claim 3 , wherein the support is a porous support having a mesh size of 1 to 150 microns.5. The device according to claim 1 , wherein the contrast agent is dispersed throughout the substrate.6. The device according to claim 1 , wherein the contrast device is configured to be removably installed in a probe path of a wellbore sensor claim 1 , wherein the wellbore sensor is an optical sensor claim 1 , an acoustic sensor claim 1 , an NMR sensor claim 1 , a dielectric sensor claim 1 , or a resistivity sensor.7. A system claim 1 , the system comprising:a wellbore fluid comprising an analyte; a substrate; and', 'a contrast agent adhered to the substrate, wherein the contrast agent is configured to respond to the analyte thereby altering a characteristic of the contrast agent;, 'a contrast device in fluid communication with the wellbore fluid, the contrast device comprisingan energy source configured to transfer energy to or through the contrast device; anda detector configured to detect ...

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Номер записи: 55
13-10-2016 дата публикации

PORTABLE CHEMICAL TESTING APPARATUS, SYSTEM, AND METHOD

Номер: US20160299160A1
Автор: DiRuggiero Christian C., DiRuggiero Crispino, DiRuggiero Michelle W.
Принадлежит: MWD TECHNOLOGIES, INC.

Embodiments of portable chemical testing apparatus, methods, and systems may provide information indicative of the presence of at least one target chemical in a liquid to be tested, such as a drink, and may include a portable housing having a storage compartment for containing dispensable personal care material and a chemical testing platform which may be brought into contact with liquid to be tested. 1. Apparatus for chemical testing , said apparatus comprising:a chemical testing platform configured for selectable exposure to a drink mixture to provide information indicative of the presence of at least one target chemical in the drink mixture;a portable housing comprising a first storage compartment, the first storage compartment having a nominal volume less than 50 milliliters, the first storage compartment configured to hold dispensable personal care material;a first cap selectively positionable relative to the first storage compartment between a closed position and an open position, in the closed position the first cap cooperating with the portable housing to prevent dispensing of the dispensable personal care material from the first storage compartment;the chemical testing platform supported by at least one of the portable housing and the first cap.2. Apparatus for chemical testing according to and further comprising:the chemical testing platform supported by said at least one of the portable housing and the first cap in movable relationship relative thereto.3. Apparatus for chemical testing according to and further comprising:the chemical testing platform being selectably movable relative to said at least one of the portable housing and the first cap between a stored position and an exposed position, the chemical testing platform configured for contacting the drink mixture in the exposed position.4. Apparatus for chemical testing according to and further comprising:the chemical testing platform configured for retaining a sample of the drink mixture upon ...

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Номер записи: 56
18-10-2018 дата публикации

TEST ELEMENTS FOR DETECTING AT LEAST ONE ANALYTE IN A BODY FLUID, AS WELL AS METHODS OF MANUFACTURING THE SAME

Номер: US20180297030A1
Автор: Hiller Bernd, Pachl Rudolf, Pfiffi Daniela, Rieger Ewald, Sternberger Christa
Принадлежит:

Methods are disclosed for manufacture of test elements for detecting at least one analyte in a body fluid, where the test elements include a housing having at least one base element and at least one cover element. The methods include providing the base element, and mounting the cover element to the base element with an adhesive, wherein the adhesive contacts at least one test field of the cover element such that the adhesive is interposed between the test field and the base element and at least partially covers the test field. The test elements also include at least one fluid channel formed within the housing, where the the fluid channel includes a capillary region and a measurement region. The capillary region and the measurement region have differing aspect ratios. The at least one test field has at least one test chemical, where the test chemical is adapted to change at least one optically measurable property in the presence of the analyte. 1. A method of manufacturing a test element for detecting at least one analyte in a body fluid , the method comprising the steps of:providing at least one base element; andmounting at least one cover element to the at least one base element by using at least one adhesive, wherein the at least one cover element comprises at least one test field having at least one test chemical, the at least one test chemical being adapted to change at least one optically measurable property in the presence of the analyte,wherein the at least one adhesive contacts the at least one test field of the at least one cover element in a manner that the at least one adhesive is interposed in between the at least one test field and the at least one base element, wherein the at least one adhesive fully or partially covers the at least one test field such that the adhesive is in direct contact with a test field surface or a part of the test field surface of the at least one test field, andwherein the at least one base element and the at least one cover ...

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Номер записи: 57
03-11-2016 дата публикации

Tobacco Smoke Detector

Номер: US20160320308A1
Автор: Liss Jonathan
Принадлежит:

A disposable, self-contained tobacco smoke detector, comprising a sensor incorporated with a reagent capable of undergoing one or more chemical reactions by interacting with one or more compounds unique to tobacco smoke. The smoking detector further comprises an indicator coupled to the sensor for visually indicating the occurrence of at least one chemical reaction by producing a detectable change in color, indicating exposure to tobacco smoke, thereby providing visual evidence of smoking. 1. A disposable , self-contained , tobacco smoke detector , comprising:a sensor incorporated with a reagent capable of undergoing at least one chemical reaction by interacting with one or more compounds unique to tobacco smoke; andan indicator coupled to the sensor for visually indicating the occurrence of the at least one chemical reaction by producing a detectable change in color so as to form a detectable color change; andwherein when the reagent interacts with the one or more compounds unique to the tobacco smoke, the at least one chemical reaction formed thereby has the detectable color change made thereto, with the detectable color change being visible via the indicator so as to provide a visual indication of the tobacco smoke.2. The tobacco smoke detector of claim 1 , further comprises a housing adapted to contain the sensor and the indicator.3. The tobacco smoke detector of claim 1 , wherein the reagent comprises at least an enzyme or a protein or a chemical substance.4. The tobacco smoke detector of claim 1 , wherein the sensor is integrated with the indicator.5. The tobacco smoke detector of claim 1 , is a self-contained unit allowing for easy transport claim 1 , installation claim 1 , and replacement.6. The tobacco smoke detector of claim 1 , is tamper resistant.7. The tobacco smoke detector of claim 1 , wherein the biological or chemical component is capable of initiating a series of chemical reactions in the presence of tobacco smoke or compounds unique to tobacco ...

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Номер записи: 58
25-10-2018 дата публикации

GLUCOSE SENSOR

Номер: US20180306802A1
Автор: Barwell Nicholas Paul, Crane Barry Colin, Edgley Peter, Paterson William
Принадлежит: LIGHTSHIP MEDICAL LIMITED

A method of quantifying the amount of glucose in a sample is provided herein that may further comprise an interferent such as mannitol. At least two measurements are obtained using measurement methods that differ in their sensitivity to the amount of interferent in the sample, thus enabling the results to be compared to determine whether any interferent is present in the sample. A glucose sensor for carrying out a method described herein is also provided 19-. (canceled)12. A method according to claim 11 , wherein said first measurement and said second measurement are obtained in a single emission detection step.13. A method according to claim 11 , wherein said first fluorophore and said second fluorophore have peak emission wavelengths that differ by at least 5 nm.14. A method according to claim 11 , wherein [K/K]/[K/K] is greater than 2 or less than 0.5.15. A method according to claim 11 , wherein said first receptor and said second receptor are boronic acid receptors.16. A method according to claim 15 , wherein said first receptor contains two boronic acid groups and said second receptor contains one boronic acid group.17. A method according to claim 10 , wherein said sample that may further comprise an interferent is an in vivo sample.18. A method according to claim 10 , wherein said sample that may further comprise an interferent is an in vivo sample and wherein said method comprises:{'sub': 'test', '(i) obtaining said first measurement at a time point t;'}{'sub': 'test', '(ii) obtaining said second measurement by said second measurement method, wherein said second measurement method comprises electrochemically measuring the amount of glucose, or of said interferent, in the sample at said time point t; and'}(iii) comparing said first measurement and said second measurement, thereby determining whether said first measurement contains a contribution from said interferent in the sample.19. A method according to claim 18 , wherein the method is carried out on a ...

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Номер записи: 59
10-11-2016 дата публикации

Flexible, Integrated Urine-Based Diagnostic Device

Номер: US20160327553A1
Автор: DiMare Francess Melina, Edwards Bethany Ann
Принадлежит:

A flexible, integrated, urine-based diagnostic device designed such that one or more diagnostic channels are integrated into the body of the device. Each diagnostic channel is designed to contain an immunoassay to detect the presence of a selected analyte so that the device can return a visible readout indicating the presence of the analyte. The flexibility of the device aids the user in the sample collection process. 1. A flexible and water-dispersible immunoassay diagnostic testing device for testing a urine sample comprising:a body formed of a flexible nonwoven, water-dispersible material configured to be adjustable to aid in the collection of urine;one or more diagnostic channels positioned in the body comprised of a nonwoven, water-dispersible material;a urine contact portion comprised of a nonwoven, water-dispersible material; anda visual indicator configured to provide a visual indication of at least one of the presence or the absence of an analyte in the sample.27-. (canceled)8. The device of claim 1 , wherein the device is foldable.9. The device of claim 1 , wherein the device is formed of a flushable material such that the entire device is flushable.10. The device of claim 9 , wherein the device is biodegradable.11. The device of claim 9 , wherein the body material claim 9 , the urine contact portion claim 9 , and the diagnostic channel material are composed of non-woven cellulose.12. The device of claim 1 , further comprising visible indicia configured to indicate the presence of a predetermined minimum volume of the urine sample sufficient for testing of the urine sample.13. The device of wherein the visible indicia includes hydrochromic ink configured to change color when exposed to the predetermined minimum volume of the urine sample.14. The device of wherein said visual indicator comprises microfluidic channels configured to display text indicating at least one of the presence or absence of at least one analyte at the predetermined concentration of ...

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Номер записи: 60
17-10-2019 дата публикации

System and method for volatile organic compound detection

Номер: US20190317079A1
Автор: Hieu DANG, Mark Alexiuk, Siavash MALEKTAJI, Wallace Trenholm
Принадлежит: Sightline Innovation Inc

A system and method for identifying an analyte based on the presence of at least one volatile organic compound (“VOC”) in the analyte. The method includes: receiving image data from a sensor array, the sensor array having been exposed to the analyte, the sensor array including at least one sensor configured to respond to the presence of the at least one VOC in the analyte; processing the image data to derive one or more input image features; and using a trained machine learning classification technique, detecting the at least one VOC and classifying the analyte based on the one or more input image features, the machine learning classification technique trained using one or more reference images of known analytes.

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Номер записи: 61
07-12-2017 дата публикации

DIAGNOSTIC TEST DEVICE WITH PATTERNED MATERIAL SPOTS

Номер: US20170350821A1
Автор: Delamarche Emmanuel, Goekce Onur, Temiz Yuksel
Принадлежит:

A test device is configured for diagnostic testing and includes an optical readable medium, in turn including a pattern of spots of material arranged on a surface of the device. Several patterns may be provided. The patterns accordingly formed may be human and/or machine readable. They may notably encode security information, e.g., indicating whether the device has already been used. The spots may notably be inkjet spotted. In addition, a method is provided for decoding information encoded in a pattern of such a test device. In embodiments, liquid is introduced in the device, which comprises additional spots having a substantially different solubility than spots forming the actual pattern. Thus, the additional spots get solubilized in and flushed by the liquid as the latter wets them, and an initially hidden pattern may be read, which is formed of the remaining spots (not solubilized). Encoding methods are also provided. 1. A test device configured for diagnostic testing , the device comprisingan optical readable medium, the medium comprising a pattern of spots of material arranged on a surface of the device.3. The test device according to claim 2 , wherein:the flow path comprises reagents for enabling said diagnostic testing; andsaid spots are located downstream the reagents with respect to the liquid inlet.4. The test device according to claim 2 , whereinsaid flow path is a first flow path and said device comprises a second flow path extending from said liquid inlet.5. The test device according to claim 3 , whereinsaid surface is a surface of a material impregnated with said reagents.6. The test device according to claim 2 , whereinsaid device comprises one or more microchannels, wherein one of said one or more microchannels comprises said spots of material.7. The test device according to claim 1 , whereinthe device further comprises a cover covering said pattern of spots, where the cover is transmissive to light.8. The test device according to claim 1 , ...

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Номер записи: 62
06-12-2018 дата публикации

Integrated Diagnostic Device

Номер: US20180344159A1
Автор: DIMARE Frances Melina, Edwards Bethany Ann
Принадлежит: LIA DIAGNOSTICS, INC.

A flexible, integrated, urine-based diagnostic device designed such that one or more diagnostic channels are integrated into the body of the device. Each diagnostic channel is designed to contain an immunoassay to detect the presence of a selected analyte so that the device can return a visible readout indicating the presence of the analyte. The flexibility of the device aids the user in the sample collection process. 1. A device for use with a fluid sample , comprising a biodegradable diagnostic device having a diagnostic channel integrated into the device material , wherein the diagnostic channel is formed of a biodegradable material and includes a biorecognition specific for an analyte in the fluid sample.2. The device of claim 1 , wherein the device is water-dispersible.3. The device of claim 1 , wherein the biodegradable material is a flushable material.4. The device of claim 1 , wherein the device is flushable.5. The device of claim 2 , wherein the diagnostic channel and the body are composed of cellulose.6. The device of claim 2 , further comprising an embossed pattern on the body or the diagnostic channel.7. The device of claim 1 , wherein the biorecognition agent is an immunoassay reagent.8. The device of claim 1 , wherein the biorecognition agent comprises multiple biorecognition agents claim 1 , each capable binding a different analyte claim 1 , if present claim 1 , in the fluid sample.9. The device of claim 2 , wherein the diagnostic channel and the body are comprised of the same water-dispersible material.10. The device of claim 1 , wherein the device is a hand-held device.11. The device of claim 1 , wherein the biodegradable material comprises a nonwoven material.12. A device for use with a fluid sample claim 1 , comprising a biodegradable diagnostic device capable detecting an analyte in the fluid sample claim 1 , wherein the biodegradable diagnostic device has a diagnostic channel formed of a biodegradable material.13. The device of claim 12 , ...

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Номер записи: 63
06-12-2018 дата публикации

DEVICES AND METHODS FOR QUANTIFICATION OF MALE FERTILITY

Номер: US20180348207A1
Автор: GONG MAX M., NOSRATI REZA, Sinton David
Принадлежит:

Disclosed herein is a low cost and rapid microfluidic based method and test device for quantifying male fertility potential. The device can simultaneously measure three critical semen parameters rapidly, namely live sperm concentration, motile sperm concentration, and sperm motility. The device includes a transparent substrate and a top sheet with two holes therethrough and an intermediate sheet sandwiched between the substrate and the top sheet. The wells formed by holes form a concentration measuring well (C) and a motility well (M) formed by the top sheet with these two holes bonded to the intermediate sheet. A colorimetric agent is located on the top surface of the intermediate sheet at the bottom of each well which changes color when in contact with sperm. In the motility well a porous membrane is located on top of the colorimetric agent and a liquid buffer may be placed on the top surface of the porous membrane. Applying part of a sperm sample to the C well results in direct contact of any live sperm with the colorimetric agent causing a color change, applying part of the sperm sample to the M well results in live sperm with sufficient motility to swim vertically down through the liquid buffer and through the porous membrane to the colorimetric agent. Evaluating the intensities of the color change of the colorimetric agents before and after contact with the sample gives a measure of total concentration of live sperm and motile sperm from which sperm motility is calculated. 1. A device for quantifying fertility potential from a semen sample , comprising:a transparent or semitransparent substrate layer;a first layer comprised of a hydrophilic porous material secured on top of the substrate layer, the first layer having first and second reaction spots spaced from each other and each reaction spot containing a colorimetric agent selected to undergo reaction with sperm such that upon reaction with sperm a color change occurs;a porous membrane covering said second ...

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Номер записи: 64
05-11-2020 дата публикации

Methods and Apparatuses Relating to Dermal Biochemical Sensors

Номер: US20200348240A1
Автор: Le Anh-Dung
Принадлежит:

Example embodiments of the present invention comprise an analyte sensing patch, comprising a substrate, and a sensing agent disposed on the substrate such that analyte can encounter the sensing agent through a side of the patch disposed adjacent the skin of a subject but not through a side of the patch disposed away from the skin of the subject. Example embodiments of the present invention comprise an analyte sensing patch, comprising a substrate, a sensing material disposed on the substrate in a first region thereof, an adhesive disposed on the substrate in a second region thereof, wherein the second region surrounds the first region, wherein the sensing agent undergoes a change in a discernible characteristic responsive to encounter with a predetermined analyte. 1. An analyte sensing patch , comprising(a) a substrate that is impermeable to an analyte; and(b) a sensing agent disposed on a first side of the substrate, in a first region of the first side of the substrate, wherein the sensing agent undergoes a change in a discernible characteristic responsive to encounter with the analyte;(c) an adhesive disposed on the first side of the substrate in a second region of the first side of the substrate, wherein the second region surrounds the first region;and (d) one or more control regions of the patch, wherein a control region exhibits a characteristic that corresponds to the characteristic of the sensing agent upon exposure to a predetermined amount of the analyte;wherein the sensing agent comprises an enzyme and a dye.2. The analyte sensing patch of claim 1 , wherein the substrate comprises a polymer suitable for transdermal patches.3. The analyte sensing patch of claim 1 , wherein the substrate comprises polyurethane.4. The analyte sensing patch of claim 1 , further comprising a reader external to the patch that detects the change in the discernible characteristic.5. The analyte sensing patch of claim 4 , wherein the discernible characteristic comprises color claim ...

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Номер записи: 65
21-11-2019 дата публикации

Portable liquid analyzer

Номер: US20190353597A1
Автор: Christian Loane, Michael D. Callahan
Принадлежит: Individual

A system is provided for identifying the presence of a target molecule or ion. The system comprises a solid support, and at least one chemical reagent applied to the solid support. Each chemical reagent produces a presumptive color indication that identifies or excludes the presence of a target molecule or ion.

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Номер записи: 66
19-11-2020 дата публикации

SENSING OF MARKERS FOR AIRBORNE PARTICULATE POLLUTION BY WEARABLE COLORIMETRY

Номер: US20200363322A1
Автор: FOLLER Peter, WROBEL Steven
Принадлежит:

A wearable pollutant indicator, methods of making and using same. The indicator includes a polymeric film substrate having a first side and a second side, an adhesive disposed on the first side of the substrate, and a readily understood user interface disposed on the second side of the substrate, wherein the user interface comprises a qualitative indicator of the accumulated exposure to incident airborne particulate pollution as sensed through the reaction of the transition metal oxides therein. 1. A wearable pollutant indicator comprising a polymeric film substrate having a first side and a second side , an adhesive disposed on the first side of the substrate , and a readily understood user interface disposed on the second side of the substrate , wherein the user interface comprises a qualitative indicator , said qualitative indicator provides a qualitative indication of the accumulated exposure to incident airborne particulate pollution as sensed through the reaction of the transition metal oxides therein.2. The wearable pollutant indicator of claim 1 , wherein the wearable pollutant indicator is wearable for the skin.3. The wearable pollutant indicator of claim 1 , wherein the polymeric film substrate comprises a polymer selected from the group consisting of polydimethylsiloxane claim 1 , thermoplastic polyurethane claim 1 , thermoplastic elastomer claim 1 , polyethylene claim 1 , and polyethylene terephthalate.4. The wearable pollutant indicator of claim 1 , wherein the qualitative indicator further comprises a redox indicator claim 1 , which produces a color change in the presence of a decomposed per-compound.5. The wearable pollutant indicator of claim 4 , wherein the per-compound is selected from the group consisting of carbamide peroxide (hydrogen peroxide complexed with urea) claim 4 , sodium perborate claim 4 , sodium persulfate claim 4 , sodium percarbonate and combinations thereof.6. The wearable pollutant indicator of wherein the redox indicator is ...

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Номер записи: 67
24-12-2020 дата публикации

FLUID SENSOR CARD

Номер: US20200400584A1
Автор: KELLEY Shawn, LURA David B.
Принадлежит: Medtronic, Inc.

The invention relates to sensor cards for determining and/or monitoring solute concentration and/or pH of a fluid based on an optically observable change of a sensing membrane or colorimetric material in the presence of ions in solution. The sensor cards can be placed in a fluid sensor apparatus and used to determine the solute concentration and/or pH of any fluid, such as dialysate. 1. A system , comprising:a fluid sensor apparatus comprising:i) at least one fluid inlet and at least one fluid outlet fluidly connected to a sampling chamber;ii) a digital camera; andiii) a light source;a sensor card comprising at least one pH sensor membrane and at least one ammonia sensor membrane; anda processor; the processor programmed to determine an ammonia content of a fluid based on an intensity of red, green, and blue light transmitted through the ammonia sensor membrane and the pH sensor membrane.2. The system of claim 1 , wherein the processor is programmed to determine a total ammonia content of a fluid based on the intensity of red claim 1 , green claim 1 , and blue light reflected from the ammonia sensor membrane and the pH sensor membrane.3. The system of claim 1 , wherein the fluid sensor apparatus is placed in a dialysate flow path.4. The system of claim 1 , further comprising a bar code on the sensor card.5. The system of claim 4 , wherein the processor is programmed to scan the bar code and to obtain calibration data based on the bar code.6. The system of claim 1 , wherein the sensor card further comprises a reference sensing region.7. The system of claim 6 , wherein the reference sensing region is a solid color.8. The system of claim 6 , wherein the processor is programmed to use an intensity of red claim 6 , green claim 6 , and blue light transmitted through the reference sensing region to determine the intensity of red claim 6 , green claim 6 , and blue light transmitted through pH sensor membrane and the ammonia sensor membrane.9. The system of claim 6 , wherein ...

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Номер записи: 68
01-07-2020 дата публикации

Device for use in the detection of binding affinities

Номер: KR102128557B1
Автор: 크리스토프 패팅어
Принадлежит: 에프. 호프만-라 로슈 아게

결합 친화성의 검출에 사용하기 위한 장치로서, 기판(3) 상에 배열된 평면 도파로(2)를 포함하고, 추가로 간섭광의 평행 광선이 평면 도파로(2)의 외면을 따라 전파하는 간섭광의 소산장(11)을 이용해 평면 도파로(2)를 통해 전파하도록 평면 도파로(2) 내로 소정의 파장의 간섭광(1)을 커플링하기 위한 소정의 길이를 갖는 광커플러(41)를 포함하는 장치가 제공된다. 평면 도파로(2)의 외면(21)은, 소산장(11)의 빛이 결합 부위에 결합한 표적 시료에 의해 회절되도록 결합 부위에 표적 시료를 결합시킬 수 있는 결합 부위를 그 위에 포함한다. 상기 결합 부위는 인접한 직선들 사이에 일정 거리로 서로에 대해 평행하게 이어지는 복수의 소정의 직선들(7)을 따라서 배열된다. 소정의 직선들(7)은, 결합 부위에 결합한 표적 시료에 의해 회절된 간섭광(12)이 평면 도파로를 통해 전파하는 간섭광의 광선 외부에서 평면 도파로(2)의 부분(10)에 배열된 추가의 광커플러(8)상에서 직선들에 대한 회절각으로 충돌하도록 소산장(11)의 전파 방향에 대한 각도로 배열된다. 추가의 광커플러(8)는 소정의 파장의 정수 배수인 광학 경로 길이에의 차이를 갖는 소정의 검출 위치(9)에서 간섭하도록 평면 도파로(2)를 벗어난 회절된 간섭광(13)을 커플링한다. An apparatus for use in the detection of binding affinity, comprising a planar waveguide (2) arranged on a substrate (3), and additionally, a dissipation field of interfering light through which parallel rays of interference light propagate along the outer surface of the planar waveguide (2) Provided is an apparatus comprising an optocoupler 41 having a predetermined length for coupling interference light 1 of a predetermined wavelength into the planar waveguide 2 to propagate through the planar waveguide 2 using (11) do. The outer surface 21 of the planar waveguide 2 includes thereon a binding site capable of binding the target sample to the binding site such that light of the dissipation field 11 is diffracted by the target sample binding to the binding site. The joining sites are arranged along a plurality of predetermined straight lines 7 running parallel to each other at a certain distance between adjacent straight lines. The predetermined straight lines 7 are additionally arranged in the portion 10 of the planar waveguide 2 outside the ray of the interfering light, which is diffracted by the target sample bound to the binding site and propagates through the planar waveguide. It is arranged at an angle to the propagation direction of the dissipation field 11 so as to collide at a diffraction angle for straight lines on the ...

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Номер записи: 69
03-01-2019 дата публикации

Sensormembran, Sensorkappe und optischer Sensor

Номер: DE102017114537A1
Автор: Andreas Löbbert
Принадлежит: Endress and Hauser Conducta GmbH and Co KG

Eine Sensormembran (13) für einen amperometrischen, potentiometrischen oder optischen Sensor (1), mit einem mehrschichtigen Aufbau umfassend zumindest zwei Schichten (17-20) wobei zumindest eine der beiden Schichten (17-20) der Sensormembran (13) Naturstoffkapseln (202) aufweist, wobei die Naturstoffkapseln (202) jeweils zumindest eine pH-puffernde funktionelle Gruppe aufweisen, sowie eine Sensorkappe (3), ein optischer Sensor (1) und ein Verfahren zu deren Herstellung.

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Номер записи: 70
14-09-1993 дата публикации

Fiber optic sensor, apparatus, and methods for detecting an organic analyte in a fluid or vapor sample

Номер: US5244813A
Автор: David R. Walt, Steven M. Bernard
Принадлежит: TUFTS UNIVERSITY

The present invention provides fiber optic sensors, apparatus, methods of optical detection, and methods of sensor manufacture for detection of organic analytes having a fixed polarity. The sensor requires an optical fiber strand; an immobilized polarity-sensitive dye; and an immobilized polymeric material which not only contains the polarity-sensitive dye but also absorbs and partitions the organic analyte of interest.

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Номер записи: 71
30-04-1996 дата публикации

Optical sensor, optical sensing apparatus, and methods for detecting an analyte of interest using spectral recognition patterns

Номер: US5512490A
Автор: David R. Walt, John S. Kauer
Принадлежит: TUFTS UNIVERSITY

The present invention is an optical detection and identification system and provides an optic sensor, an optic sensing apparatus and methodology for detecting and evaluating one or more analytes or ligands of interest, either alone or in admixture. The optic sensor of the system is comprised of a supporting member and an array formed of heterogeneous, semi-selective thin films which function as sensing receptor units and are able to detect a variety of different analytes and ligands using spectral recognition patterns.

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Номер записи: 72
05-08-2015 дата публикации

결합 친화성의 검출에 사용하기 위한 장치

Номер: KR20150090034A
Автор: 크리스토프 패팅어
Принадлежит: 에프. 호프만-라 로슈 아게

결합 친화성의 검출에 사용하기 위한 장치로서, 기판(3) 상에 배열된 평면 도파로(2)를 포함하고, 추가로 간섭광의 평행 광선이 평면 도파로(2)의 외면을 따라 전파하는 간섭광의 소산장(11)을 이용해 평면 도파로(2)를 통해 전파하도록 평면 도파로(2) 내로 소정의 파장의 간섭광(1)을 커플링하기 위한 소정의 길이를 갖는 광커플러(41)를 포함하는 장치가 제공된다. 평면 도파로(2)의 외면(21)은, 소산장(11)의 빛이 결합 부위에 결합한 표적 시료에 의해 회절되도록 결합 부위에 표적 시료를 결합시킬 수 있는 결합 부위를 그 위에 포함한다. 상기 결합 부위는 인접한 직선들 사이에 일정 거리로 서로에 대해 평행하게 움직이는 복수의 소정의 직선들(7)을 따라서 배열된다. 소정의 직선들(7)은, 결합 부위에 결합한 표적 시료에 의해 회절된 간섭광(12)이 평면 도파로를 통해 전파하는 간섭광의 광선 외부에서 평면 도파로(2)의 부분(10)에 배열된 여분의 광커플러(8)상에서 직선들에 대한 회절각으로 충돌하도록 소산장(11)의 전파 방향에 대한 각도로 배열된다. 추가의 광커플러(8)는 소정의 파장의 정수 배수인 광학 경로 길이에의 차이를 갖는 소정의 검출 위치(9)에서 간섭하도록 평면 도파로(2)를 벗어난 회절된 간섭광(13)을 커플링한다.

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Номер записи: 73
30-09-2008 дата публикации

A multi-channel bioreactor with the immobillization of optical sensing membrane

Номер: KR100860958B1
Автор: 손옥재, 이종일
Принадлежит: 전남대학교산학협력단

A multi-channel bio-reactor is provided to detect dissolved oxygen, CO2, pH, monosaccharides, polysaccharides, organic acids, alcohols, cholesterols, cholines and xanthines in situ through optical detection. A multi-channel bio-reactor comprises a plurality of wells where an optical sensing membrane is formed, wherein the optical sensing membrane includes a fluorescent dye and a bio-conjugate or a sensor material where a bio-molecule is encapsulated into the fluorescent dye and the bio-conjugate, wherein the fluorescent dye is a ruthenium complex, HPTS(8-hydroxypyrene-1,3,6-trisulfonic acid trisodium salt) or fluoresceinamine and the bio-molecule is protein, amino acid, enzyme, antigen or antibody. Further, the fluorescent dye detects optically dissolved oxygen, CO2 and pH.

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Номер записи: 74
10-01-2017 дата публикации

Устройство для применения при детектировании сродства к связыванию

Номер: RU2015125027A
Автор: Кристоф ФАТТИНГЕР
Принадлежит: Ф. Хоффманн-Ля Рош Аг

РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 2015 125 027 A (51) МПК G01N 21/77 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ЗАЯВКА НА ИЗОБРЕТЕНИЕ (21)(22) Заявка: 2015125027, 03.12.2013 (71) Заявитель(и): Ф. ХОФФМАНН-ЛЯ РОШ АГ (CH) Приоритет(ы): (30) Конвенционный приоритет: (72) Автор(ы): ФАТТИНГЕР Кристоф (CH) 04.12.2012 EP 12195532.2 (85) Дата начала рассмотрения заявки PCT на национальной фазе: 06.07.2015 R U (43) Дата публикации заявки: 10.01.2017 Бюл. № 01 (86) Заявка PCT: (87) Публикация заявки PCT: WO 2014/086789 (12.06.2014) A Адрес для переписки: 197046, Санкт-Петербург, Каменноостровский пр-кт, 1-3, оф. 30, ООО "Юридическая фирма Городисский и Партнеры" R U (57) Формула изобретения 1. Устройство для применения в детектировании сродства к связыванию, содержащее планарный волновод (2) расположенный на подложке (3), и дополнительно содержащее оптическую развязку (41), имеющую заранее определенную длину для введения когерентного света (1) заранее определенной длины волны в планарный волновод (2) таким образом, чтобы когерентный свет распространялся через планарный волновод (2) с полем (11) затухающих колебаний параллельно с когерентным светом, распространяющимся вдоль внешней поверхности (21) планарного волновода (2), содержащей на ней центры (5) связывания, способные к связыванию заданных образцов (6) с центрами (5) связывания, таким образом, чтобы свет поля (11) затухающих колебаний преломлялся заданными образцами (6), связанными с центрами (5) связывания, в особенности, с центрами (5) связывания, расположенными вдоль множества заранее определенных линий (7), проложенных взаимно параллельно, имеющих постоянное расстояние между прилежащими прямыми линиями, а именно заранее определенными линиями из множества определенных линий (7), расположенных под углом (β) относительно направления распространения поля (11) затухающих колебаний, чтобы когерентный свет (12), преломленный заданными образцами (6), связанными с центрами (5) связывания падал ...

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Номер записи: 75
11-08-2022 дата публикации

화학 분석 및 관련 방법을 위한 프로브

Номер: KR20220112816A
Автор: 김동섭, 로버트 토커, 사무엘 죠지 더닝, 사무엘 티. 칠, 사이먼 엠. 험프리, 탈리사 밴위
Принадлежит: 란타 인코포레이티드

본 개시는 화학 조성물 분석용 프로브, 및 관련된 화학 조성물 분석 방법 및 화학 조성물 분석용 프로브의 제조 방법에 관한 것이다. 개시된 프로브 및 방법의 이점은 광범위한 화학 조성물의 신속, 정확, 휴대가능하며 경제적인 정성 및 정량 분석을 위한 발광 화학 센서 어레이를 포함할 수 있다. 본원에 개시된 방법의 이점은 화학 조성물에 존재하는 미량 화학물질의 신속하고 간단하며 정확한 분석을 포함할 수 있다.

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Номер записи: 76
23-10-2012 дата публикации

Plasma deposited microporous analyte detection layer

Номер: US8293340B2
Автор: Dora M. Paolucci, John E. Trend, Moses M. David, Neal A. Rakow
Принадлежит: 3M Innovative Properties Co

Plasma deposited microporous analyte detection layers, method of forming analyte detection layers, and analyte sensors including the same are disclosed. An analyte sensor includes a substrate and a microporous amorphous random covalent network layer. The microporous amorphous random covalent network layer includes silicon, carbon, hydrogen and oxygen with a mean pore size in a range from 0.5 to 10 nanometers and an optical thickness in a range from 0.2 to 2 micrometers.

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Номер записи: 77
16-03-2016 дата публикации

Aquatic environment water parameter testing systems and methods

Номер: CN105408736A
Автор: J·E·克拉克
Принадлежит: STEP AHEAD INNOVATIONS Inc

本发明公开了水生环境水参数测试系统和相关方法以及化学指示剂元件。所述水生环境水参数测试系统包括具有光学读取器元件的电子设备部分和具有化学指示剂元件的样品室部分，所述化学指示剂元件可以被可移除地连接。化学指示剂元件可以包括信息存储和通信元件，所述信息存储和通信元件部分地用于提供所述化学指示剂元件的化学指示剂的识别。可以使用电导率和/或温度以通过所述光学读取器元件来校准读数。化学指示剂元件还可以包括薄膜材料，所述薄膜材料具有与来自光源(诸如光学读取器元件的光源)的光相关联的特定光学特性。

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Номер записи: 78
17-07-2013 дата публикации

Plasma deposited microporous analyte detection layer

Номер: CN101341404B
Автор: 多拉·M·保卢奇, 尼尔·A·拉科, 约翰·E·特伦德, 莫塞斯·M·大卫
Принадлежит: 3M Innovative Properties Co

本发明公开了等离子体沉积的微孔分析物检测层、形成分析物检测层的方法以及包括所述等离子体沉积微孔分析物检测层的分析物传感器。分析物传感器包括基底和微孔无定形无规共价网络层。所述微孔无定形无规共价网络层包括硅、碳、氢和氧，具有0.5至10纳米范围的平均孔尺寸和0.2至2微米范围的光学厚度。

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Номер записи: 79
31-05-2022 дата публикации

High pressure sensitive color changeable indicators and methods of making such indicators

Номер: US11346786B2
Автор: Andrew Mills, Gregory L. Heacock
Принадлежит: SENSOR INTERNATIONAL LLC

The present technology includes a color changeable indicator that changes color upon exposure of the indicator to high pressure and comprises at least one reagent releasing layer, a transition layer disposed on the reagent releasing layer, a color changeable layer disposed on the transition layer, and a non-porous protectant encompassing the reagent releasing layer, the transition layer and the color changeable layer. An additional reagent releasing layer can be located between the transition layer and the color changeable layer. The indicators provide simple, reliable, and cost effective detection means for detecting whether a product has been exposed to high pressure, e.g. high pressure pasteurization, and may find use in applications such as food and beverage processing and/or packaging and medical applications.

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Номер записи: 80
26-07-2012 дата публикации

Method and apparatus for detecting and evaluating gas component in mixed gases

Номер: KR101169207B1
Автор: 송용원, 최성훈
Принадлежит: 한국과학기술연구원

본 발명은 탄소나노튜브 또는 광학적으로 큰 민감성을 가지는 나노 구조체를 광섬유에 코팅하여 광섬유 센서를 형성함에 있어서 D형 광섬유에 브래그 (Bragg) 격자나 장주기 격자 형태, 또는 광섬유 끝단에 나노 물질 막을 생성하는 형태를 도입하고 이를 광섬유 센서 어레이로 만들어 혼합된 다중의 검지물이 각각의 나노 물질에 흡착하여 일으키는 굴절률 변화에 의해 반사 또는 투과 되는 센서 어레이 전체 광신호를 개별 센서에서의 신호 간 시간 지연 효과로 중첩을 방지하여 전체 신호를 구성한 후 전류 신호로 변환 후 굴절률 변화를 계산하고 각 센서에 의해 변화된 굴절률을 나타내는 방정식을 N×N 차 행렬식으로 처리하여 단일 측정으로도 가스의 종류와 혼합 성분을 정량화할 수 있는 혼합 가스의 성분 검출 장치 및 방법에 관한 것이다. 본 발명에 적용되는 광섬유 센서로는 D형의 광섬유 브래그격자나 장주기 격자, 또는 광섬유 끝단에 나노물질 막을 형성한 패브리페롯 (FABRY-PEROT) 센서를 사용할 수 있으며, 이 D형 광섬유 센서의 경우에는 단면상 평평한 면의 코어 부분에, 탄소나노튜브(CNT), 산화아연(ZnO), 이산화티타늄(TiO2), 이산화주석 (SnO2) 과 같은 나노 물질을 주기적으로 코팅 배열 하여 서로 다른 나노물질이 코팅 된 개별 센서를 어레이로 제작하고 D형 단면이 외측으로 배향되어 검지 물질에 노출 되도록 구성되며 패브리페롯 센서의 경우 광섬유 끝단에 각각의 상기 나노물질들을 균일 코팅하여 어레이로 제작된 혼합 가스의 성분 검출 장치를 제공한다. 또한, 펄 스 레이저로부터 광신호가 광섬유를 따라 진행하다 검지 대상 물체가 코팅된 나노 물질에 흡착되어 일으키는 굴절률 변화에 의해 반사 또는 투과 되어 나오는 파형의 특성 즉 파장의 이동과 세기의 변화를 계산하고 굴절률을 나타내는 방정식을 풀어 혼합 물질을 정성적, 정량적으로 측정할 수 있는 혼합 가스의 성분 검출 장치 및 방법을 제공한다. 광섬유 센서, 가스 센서, 탄소나노튜브 가스 센서, D 형 광섬유, 브레그 격자 광섬유 센서, 가스 검출 장치, 혼합 가스 검출 장치

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Номер записи: 81
20-11-2013 дата публикации

Plasma deposited microporous analyte detection layer

Номер: KR101331710B1
Автор: 닐 에이. 라코우, 도라 엠. 파오루치, 모스 엠. 데이비드, 존 이. 트렌드
Принадлежит: 쓰리엠 이노베이티브 프로퍼티즈 컴파니

플라즈마 증착된 미공성 분석물 검출 층과, 분석물 검출 층을 형성하는 방법과, 분석물 검출 층을 포함하는 분석물 검출 센서가 개시된다. 분석물 센서는 기판과, 미공성 비정질 랜덤 공유 망상조직 층을 포함한다. 미공성 비정질 랜덤 공유 망상조직 층은 규소, 탄소, 수소 및 산소를 포함하며, 0.5 내지 10 나노미터 범위 내의 평균 기공 크기 및 0.2 내지 2 마이크로미터 범위 내의 광학 두께를 구비한다. An analyte detection sensor is disclosed that includes a plasma deposited microporous analyte detection layer, a method of forming an analyte detection layer, and an analyte detection layer. The analyte sensor includes a substrate and a layer of microporous amorphous random shared network. The microporous amorphous random covalent network layer comprises silicon, carbon, hydrogen and oxygen and has an average pore size in the range of 0.5 to 10 nanometers and an optical thickness in the range of 0.2 to 2 micrometers. 플라즈마, 증착, 미공성, 다공성, 분석물, 검출, 센서 Plasma, Deposition, Microporous, Porous, Analyte, Detection, Sensor

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Номер записи: 82
18-04-1989 дата публикации

Radiative and non-radiative energy transfer and absorbance modulated fluorescence detection methods and sensors

Номер: US4822746A
Автор: David R. Walt
Принадлежит: TUFTS UNIVERSITY

A variety of methods and apparatus for the detection of an analyte of interest in a fluid sample is provided which relies upon the interaction of a fluorophore and a chromophoric light absorbing compound for qualitative and quantitative results. The methods preferably employ fiber optic sensors in combination with fluorophores and/or proto-absorber substances in mobile and immobilized modes of use. The methods and apparatus rely upon the ability of the light absorbing compositions to absorb energy which is transferred either radiatively or non-radiatively by the fluorophore when in an excited state.

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Номер записи: 83
19-05-1992 дата публикации

Fiber optic sensors, apparatus, and detection methods using fluid erodible controlled release polymers for delivery of reagent formulations

Номер: US5114864A
Автор: David R. Walt
Принадлежит: TUFTS UNIVERSITY

An improved fiber optic sensor, sensing apparatus, and methods for making optical determinations are provided. The fiber optic sensor employs a fiber optic strand to convey light energy and at least one polymer matrix comprising a fluid erodible, continuous release polymer and a releasable reagent formulation able to react with a molecule or analyte of interest. The optic sensors and sensor construction has been demonstrated to be accurate, precise, and of long duration.

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Номер записи: 84
12-10-1993 дата публикации

Fiber optic sensors, apparatus, and detection methods using controlled release polymers and reagent formulations held within a polymeric reaction matrix

Номер: US5252494A
Автор: David R. Walt
Принадлежит: TUFTS UNIVERSITY

An improved fiber optic sensor, sensing apparatus, and methods for making optical detections are provided. The fiber optic sensor employs a fiber optic strand to convey light energy, an immobilized polymeric reaction matrix, and at least one controlled release polymeric carrier within said reaction matrix comprising a controlled release polymer material and a releasable reagent formulation able to react with the analyte of interest. The optic sensors and sensor construction have been demonstrated to be both functionally useful and long serving in duration.

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Номер записи: 85
01-09-1992 дата публикации

Absorbance modulated fluorescence detection methods and sensors

Номер: US5143853A
Автор: David R. Walt
Принадлежит: TUFTS UNIVERSITY

A variety of methods and apparatus for the detection of an analyte of interest in a fluid sample is provided which relies upon the interaction of a fluorophore and a chromophoric light absorbing compound for qualitative and quantitative results. The methods preferably employ fiber optic sensors in combination with fluorophores and/or proto-absorber substances in mobile and immobilized modes of use. The methods and apparatus rely upon the ability of the light absorbing compositions to absorb energy which is transferred either radiatively or non-radiatively by the fluorophore when in an excited state.

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Номер записи: 86
14-09-1993 дата публикации

Imaging fiber optic array sensors, apparatus, and methods for concurrently detecting multiple analytes of interest in a fluid sample

Номер: US5244636A
Автор: David R. Walt, Steven M. Barnard
Принадлежит: TUFTS UNIVERSITY

The present invention provides a unique fiber optic sensor which is able to conduct multiple assays and analysis concurrently using a plurality of different dyes immobilized at individual spatial positions on the surface of the sensor. The present invention also provides apparatus for making precise optical determinations and measurements for multiple analytes of interest concurrently and provides methods of detection for multiple analytes of interest which can be correlated with specific parameters or other ligands for specific applications and purposes.

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Номер записи: 87
14-06-1994 дата публикации

Fiber optic array sensors, apparatus, and methods for concurrently visualizing and chemically detecting multiple analytes of interest in a fluid sample

Номер: US5320814A
Автор: David R. Walt, Steven M. Barnard
Принадлежит: TUFTS UNIVERSITY

The present invention provides a unique fiber optic sensor which is able to provide a viewing zone for visual examination of a sample and its surrounding environment; and is able to conduct multiple assays concurrently using a plurality of different dyes immobilized at individual spatial positions within a dye sensing zone on the surface of the sensor. The present invention also provides apparatus for making precise optical determinations and measurements for multiple analytes of interest concurrently and provides methods of detection for multiple analytes of interest which can be correlated with specific parameters or other ligands for specific applications and purposes.

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Номер записи: 88
05-10-1993 дата публикации

Method of making imaging fiber optic sensors to concurrently detect multiple analytes of interest in a fluid sample

Номер: US5250264A
Автор: David R. Walt, Steven M. Barnard
Принадлежит: TUFTS UNIVERSITY

The present invention provides a unique fiber optic sensor which is able to conduct multiple assays and analyses concurrently using a plurality of different dyes immobilized at individual spatial positions on the surface of the sensor. The present invention also provides apparatus for making precise optical determinations and measurements for multiple analytes of interest concurrently and provides methods of detection for multiple analytes of interest which can be correlated with specific parameters or other ligands for specific applications and purposes.

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Номер записи: 89
29-03-1994 дата публикации

Thin film fiber optic sensor array and apparatus for concurrent viewing and chemical sensing of a sample

Номер: US5298741A
Автор: David R. Walt, Karen S. Bronk
Принадлежит: TUFTS UNIVERSITY

The present invention provides a unique fiber optic sensor which is able to provide a visual examination of a sample and its surrounding environment concurrent with the ability to conduct chemical sensing and detection of at least one ligand of interest. The present invention also provides apparatus for making precise optical determinations and measurements for the ligand of interest which can be correlated with specific parameter or other ligands for specific applications and purposes.

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Номер записи: 90
17-11-2022 дата публикации

Medical inspection device and measuring member of medical inspection device

Номер: KR20220153058A
Автор: 레이 리우, 슈펭 장, 시아오동 두안
Принадлежит: 안콘 메디컬 테크놀로지스 (상하이) 컴퍼니 리미티드

본 출원은 의료용 검사 장치 및 의료용 검사 장치의 측정 부재에 관한 것이며, 상기 의료용 검사 장치는, 하우징, 및 상기 하우징의 외벽에 장착되고 상기 하우징의 외부 환경에서 측정하고자는 매개변수의 농도를 측정하도록 구성되는 측정 부재를 포함한다. 따라서, 본 출원의 실시예 중의 의료용 검사 장치는 측정 부재를 설치함으로써, 소화관 내의 각 매개변수(pH값, 잠혈 농도, 펩신 농도 및 트립신 농도 등을 포함)에 대한 검사를 실현할 수 있어, 소화관에 대한 해당 의료용 검사 장치의 검사 결과의 정확도를 향상시켜, 의료용 검사 장치가 여러가지 기능을 구비하도록 하고, 그의 실용성을 향상시킬 수 있다.

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Номер записи: 91
22-09-2011 дата публикации

Methods for multiplexing recombinase polymerase amplification

Номер: AU2006339057B2
Автор: Colin H. Williams, Niall A. Armes, Olaf Piepenburg
Принадлежит: Abbott Diagnostics Scarborough Inc

This disclosure provides for methods and reagents for rapid multiplex RPA reactions and improved methods for detection of multiplex RPA reaction products. In addition, the disclosure provides new methods for eliminating carryover contamination between RPA processes.

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Номер записи: 92
16-03-2017 дата публикации

Method for copper (ii) and manganese (ii) determination by indicating tube in case of their joint presence in solutions for natural waters analysis

Номер: RU2613407C1
Автор: Валентина Викторовна Жаркова, Людмила Александровна Бобкова
Принадлежит: Федеральное государственное автономное образовательное учреждение высшего образования "Национальный исследовательский Томский государственный университет" (ТГУ, НИ ТГУ)

FIELD: chemistry. SUBSTANCE: invention can be used for semiquantitative manganese (II) and copper (II) determination in aqueous solutions, in particular in natural and waste waters under field conditions. The method comprises filling of a glass tube with an inner diameter of 0.5 cm with Na- form of macroreticular carbonaceous resin "КБ-2Э-16" based on polymethacrylate diethylene glycol divinyl ether, followed by filling with the sample solution. At that, at the first stage, copper (II) is determined visually along the length of the coloured resin area at a pH of about 4.5 and ionic strength of 0.1 (NaNO 3 ) of the analyzed solution. At the second stage, after solution passage, manganese (II) is determined along the length of the coloured resin area which appears with the addition of formaldoxime complexing agent and NaOH to the indicator tube to create pH ~10. EFFECT: method reduces complexity, reduces the amount of reagents and time of analysis for copper and manganese determination in an aqueous solution under field and laboratory conditions. 2 dwg, 1 ex РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 2 613 407 C1 (51) МПК G01N 31/22 (2006.01) G01N 21/78 (2006.01) C01G 3/00 (2006.01) C01G 45/00 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ФОРМУЛА (21)(22) Заявка: ИЗОБРЕТЕНИЯ К ПАТЕНТУ РОССИЙСКОЙ ФЕДЕРАЦИИ 2015139564, 18.09.2015 (24) Дата начала отсчета срока действия патента: 18.09.2015 (72) Автор(ы): Жаркова Валентина Викторовна (RU), Бобкова Людмила Александровна (RU) 16.03.2017 Приоритет(ы): (22) Дата подачи заявки: 18.09.2015 (45) Опубликовано: 16.03.2017 Бюл. № 8 (56) Список документов, цитированных в отчете о поиске: RU 2253864 C1, 10.06.2005. RU 2262102 С1, 10.10.2005. JP S5538419 B2, 03.10.1980. JP S54119326 A, 17.09.1979. US 5002645 A, 26.03.1991. 2 6 1 3 4 0 7 R U (57) Формула изобретения Способ определения меди(II) и марганца(II) при их совместном присутствии в водных растворах индикаторным составом, осуществляемый в две стадии, ...

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Номер записи: 93
22-06-2015 дата публикации

Analytical aid

Номер: KR101530804B1
Автор: 칼-하인츠 쉐러, 한스 리슈트
Принадлежит: 에프. 호프만-라 로슈 아게

본 발명은, 샘플, 특히 체액 중 적어도 하나의 분석물질을 검출하기 위한 분석 보조기구 (112) 를 제조하는 방법에 관한 것이다. 분석 보조기구 (112) 는 적어도 하나의 하우징 (120), 및 적어도 하나의 화학 테스트 시스템 (134) 을 가지는 적어도 하나의 테스트 요소 (122) 를 포함한다. 본 방법은 다음 단계들: a) 테스트 요소 (122) 를 제공하는 단계; 및 b) 적어도 하나의 성형 프로세스에 의하여 하우징 (120) 의 적어도 하나의 하우징 부분 (114) 을 제조하는 단계를 포함하고, 테스트 요소 (122) 는 성형 프로세스 중 하우징 부분 (114) 에 연결된다. The present invention relates to a method of manufacturing an analysis aid (112) for detecting at least one analyte in a sample, particularly a body fluid. The analysis aid 112 includes at least one test element 122 having at least one housing 120 and at least one chemical test system 134. The method includes the following steps: a) providing a test element 122; And b) fabricating at least one housing portion (114) of the housing (120) by at least one forming process, wherein the test element (122) is connected to the housing portion (114) during the molding process.

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Номер: US7435561B2
Автор: Colin H. Williams, Niall A. Armes, Olaf Piepenburg
Принадлежит: TwistDix Inc

This disclosure provides for methods and reagents for rapid multiplex RPA reactions and improved methods for detection of multiplex RPA reaction products. In addition, the disclosure provides new methods for eliminating carryover contamination between RPA processes.

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Methods for multiplexing recombinase polymerase amplification

Номер: US10538760B2
Автор: Colin H. Williams, Niall A. Armes, Olaf Piepenburg
Принадлежит: Alere San Diego Inc

This disclosure provides for methods and reagents for rapid multiplex RPA reactions and improved methods for detection of multiplex RPA reaction products. In addition, the disclosure provides new methods for eliminating carryover contamination between RPA processes.

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22-11-2011 дата публикации

Methods for multiplexing recombinase polymerase amplification

Номер: US8062850B2
Автор: Colin H. Williams, Niall A. Armes, Olaf Piepenburg
Принадлежит: Alere San Diego Inc

This disclosure provides for methods and reagents for rapid multiplex RPA reactions and improved methods for detection of multiplex RPA reaction products. In addition, the disclosure provides new methods for eliminating carryover contamination between RPA processes.

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Номер записи: 97
28-01-2015 дата публикации

Kit for multiplexing recombinase polymerase amplification

Номер: EP2829615A1
Автор: Colin H. Williams, Niall A. Armes, Olaf Piepenburg
Принадлежит: Alere San Diego Inc

This disclosure provides for methods and reagents for rapid multiplex RPA reactions and improved methods for detection of multiplex RPA reaction products. In addition, the disclosure provides new methods for eliminating carryover contamination between RPA processes.

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Номер записи: 98
03-04-2018 дата публикации

Methods for multiplexing recombinase polymerase amplification

Номер: US9932577B2
Автор: Colin H. Williams, Niall A. Armes, Olaf Piepenburg
Принадлежит: Alere San Diego Inc

This disclosure provides for methods and reagents for rapid multiplex RPA reactions and improved methods for detection of multiplex RPA reaction products. In addition, the disclosure provides new methods for eliminating carryover contamination between RPA processes.

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Номер записи: 99
09-11-2011 дата публикации

Methods for multiplexing recombinase polymerase amplification

Номер: EP2385140A1
Автор: Colin H. Williams, Niall A. Armes, Olaf Piepenburg
Принадлежит: TwistDix Inc

This disclosure provides for methods and reagents for rapid multiplex RPA reactions and improved methods for detection of multiplex RPA reaction products. In addition, the disclosure provides new methods for eliminating carryover contamination between RPA processes.

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Номер записи: 100