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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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Форма поиска

Поддерживает ввод нескольких поисковых фраз (по одной на строку). При поиске обеспечивает поддержку морфологии русского и английского языка
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Применить Всего найдено 33077. Отображено 100.
05-01-2012 дата публикации

Instrument for cassette for sample preparation

Номер: US20120003631A1
Принадлежит: GENTURADX Inc

A parallel processing system for processing samples is described. In one embodiment, the parallel processing system includes an instrument interface parallel controller to control a tray motor driving system, a close-loop heater control and detection system, a magnetic particle transfer system, a reagent release system, a reagent pre-mix pumping system and a wash buffer pumping system.

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05-01-2012 дата публикации

Portable sample analyzer cartridge

Номер: US20120003730A1
Принадлежит: Honeywell International Inc

A sample analyzer cartridge for use at a point of care of a patient such as in a doctor's office, in the home, or elsewhere in the field. By providing a removable and/or disposable cartridge with all of the needed reagents and/or fluids, the sample analyzer can be reliably used outside of the laboratory environment, with little or no specialized training.

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05-01-2012 дата публикации

Automated calibration method and system for a diagnostic analyzer

Номер: US20120005150A1
Автор: Jeremy Hammond
Принадлежит: Idexx Laboratories Inc

A method to track stability and performance of diagnostic instrumentation, especially for veterinary automated hematology analyzers, applies a weighted moving averages algorithm to the diagnostic results of patient samples calculated by the analyzer. Control chart rules are used to set limits or ranges in order to determine if weighted averaged diagnostic results are within or outside of such limits or ranges. If the weighted average diagnostic results are outside of such control chart rule limits, then fuzzy logic and a gradient descent algorithm are applied to the weighted averaged diagnostic results.

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19-01-2012 дата публикации

Method for operating an analytical apparatus

Номер: US20120015447A1

A method for operating an analytical apparatus for determining concentration of an analyte, especially an oxidizable substance, in a sample liquid, comprises the steps of: placing the analytical apparatus in maintenance operation; operating a metering system, which includes a pump, especially a peristaltic pump, and a supply line, for metering single volume units of a sample liquid from a source via the supply line into a reactor, wherein there exists in the reactor a temperature, which is greater than the boiling temperature of the sample liquid, so that a volume unit of the sample liquid metered into the reactor transforms at least partially into the gas phase following entry into the reactor, especially due to heat transfer from contact with a surface within the reactor, especially directly after contact with the surface within the reactor, and wherein a carrier gas is flowing through the reactor; registering at least one measuring transducer signal for detection of the transforming of the volume unit of the sample liquid into the gas phase, and deriving, with application of the measuring transducer signal, a signal correlated with an instantaneous operating state of the metering system.

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26-01-2012 дата публикации

Mechanical holder for surface analysis

Номер: US20120018629A1
Принадлежит: Advion Biosystems Inc

A mechanical holder that provides for a confined sampling region for extraction and removal of chemical substances contained in a dried blood spot or other spot of sample is described herein.

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26-01-2012 дата публикации

Belt Agitation System For Culture Bottles

Номер: US20120021452A1
Автор: James C. Bishop
Принадлежит: Biomerieux Inc

A specimen culture container agitation assembly includes an endless belt having a multitude of container-receiving clips attached thereto, each of which is adapted for retaining a specimen culture container to the belt. The belt is oriented vertically. The assembly further includes upper and lower pulleys over which the belt is driven. A drive motor drives the belt around the pulleys. Agitation of the specimen culture container is achieved by rotation of the belt over the pulleys and the retaining of the specimen culture container by the clip.

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02-02-2012 дата публикации

Method, System and Apparatus for Incorporating Capacitive Proximity Sensing in an Automated Fluid Transfer Procedure

Номер: US20120024055A1
Принадлежит: Gen Probe Inc

A fluid transfer apparatus includes a fluid transfer probe, a fluid level detection system, and a tip detection system. The fluid level detection system is configured to detect contact by the fluid transfer probe with a fluid surface within a receptacle from a signal based on the capacitance of the fluid transfer probe. The tip detection system is configured to detect the presence or absence of a tip at a distal end of the fluid transfer probe from a signal based on the capacitance of the fluid transfer probe.

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08-03-2012 дата публикации

In situ heat induced antigen recovery and staining method

Номер: US20120058570A1
Автор: Lee Angros
Принадлежит: Individual

An automated in situ heat induced antigen recovery and staining method and apparatus for treating a plurality of microscope slides. The process of heat induced antigen recovery and the process of staining the biological sample on the microscope slide are conducted in the same apparatus, wherein the microscope slides do not need to be physically removed from one apparatus to another. The reaction conditions for treating a slide can preferably be controlled independently, including the individualized application of reagents to each slide and the individualized treatment of each slide.

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22-03-2012 дата публикации

Analyzer Assembly Platform

Номер: US20120067801A1
Принадлежит: Roche Molecular Systems Inc

A method for mounting and combination of an analytical apparatus with a platform for mounting such an apparatus comprising at least two units, and a platform on which said apparatus is mounted is disclosed, said platform comprising at least one platform element, and multiple feet for placing the platform elements on a surface. The feet are individually adjustable in height.

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29-03-2012 дата публикации

Transport and handling retention member

Номер: US20120073703A1
Принадлежит: LCTech GmbH

The transport and handling retention member comprises an adapter ring which has a central opening for receiving a tubular container for receiving samples, a gripping member for gripping the adapter ring, and a transfer head which can be moved between a rest position and an operating position, the transfer head in the operating position coming into operational contact with a tubular container which is received in the adapter ring.

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05-04-2012 дата публикации

Automatic analyzer with the function of rendering reagent information unreadable

Номер: US20120080516A1
Принадлежит: Hitachi High Technologies Corp

The invention provides an automatic analyzer suitable for efficient reagent management. The analyzer allows continued use of existing reagent information storage media because reagent ID information that is no longer needed is overwritten so that it is unrecognizable to any analyzer. The invention relates to a method for automatically analyzing particular properties of an analyte by putting the analyte and a reagent into a vessel and measuring the reacted analyte-reagent mixture. The analyzer of the invention comprises: an information reader/writer for reading or writing regent information to/from storage media attached to reagent vessels; means for managing reagent information read from the storage media; means for processing reagents based on the managed information; and means for overwriting reagent information that has been judged unnecessary based on the managed information so that the unnecessary information is unrecognizable to any analyzer.

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03-05-2012 дата публикации

Encapsulated reagents and methods of use

Номер: US20120107834A1
Автор: Lee H. Angros
Принадлежит: Individual

The present invention contemplates use of encapsulated aqueous and non-aqueous reagents, solutions and solvents and their use in laboratory procedures. These encapsulated aqueous or non-aqueous reagents, solutions and solvents can be completely contained or encapsulated in microcapsules or nanocapsules that can be added to an aqueous or non-aqueous carrier solution or liquid required for medical and research laboratory testing of biological or non-biological specimens.

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03-05-2012 дата публикации

Analysis reagent and analysis device having the analysis reagent carried therein

Номер: US20120107850A1
Принадлежит: Panasonic Corp

A reagent including a combination of a polyanionic compound and a bivalent cationic compound contains one substance selected from the group consisting of succinic acid, gluconic acid, alanine, glycine, valine, histidine, maltitol, and mannitol or at least one compound of the substance. A dry state of the reagent and deliquescence can be improved.

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17-05-2012 дата публикации

Apparatus and method for separating and isolating components of a biological fluid

Номер: US20120122649A1
Принадлежит: Individual

A device for separating and isolating components of a biological fluid comprising a container for containing the fluid to be processed, a tube cap assembly for closing the container while providing filling and extraction communication therewith, a float assembly disposed within the container for funneling and controlling biological fluid flow into an inverted domed shaped isolation chamber within the float and controlling the biological fluid flow out of the isolation chamber for effecting an encapsulation or a sealed isolation of at least one component or fraction of the biological fluid flow within the isolation chamber during a centrifugation process. The device further comprising a flexible tube for connecting an extraction passageway disposed within the float assembly and an extraction valve of the tube cap assembly for allowing extraction of at least the one component or fraction encapsulated or isolated within the chamber.

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24-05-2012 дата публикации

Automatic analyzer

Номер: US20120128534A1
Принадлежит: Hitachi High Technologies Corp

An automatic analyzer has a noncontact identification medium with an antenna, a communication device for communicating with the noncontact identification medium, a container for containing a liquid, and a container holding mechanism in which the container is to be placed, the antenna being placed in an asymmetric position relative to the container. The automatic analyzer includes an identification mechanism. When the noncontact identification medium provided for the container cannot communicate with the communication device, the identification mechanism moves the container a predetermined distance by driving the container holding mechanism, causes the noncontact identification medium to communicate with the communication device, and identifies an orientation of the container placed in the container holding mechanism.

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24-05-2012 дата публикации

Sample analyzer

Номер: US20120129247A1
Принадлежит: Sysmex Corp

A sample analyzer for analyzing a sample with a liquid in a container is disclosed. The sample analyzer comprises: a reader that reads an information of a liquid in a container, the information of the liquid being stored in a storage medium; a display; and a controller including a processor and a memory under control of the processor, the memory storing instruction causing the processor to carry out operations comprising: determining whether the sample analyzer is ready to read the information of the liquid by the reader; and causing, when the sample analyzer is determined to be ready, the display to display an indication that indicates the sample analyzer is ready to read the information of the liquid by the reader.

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24-05-2012 дата публикации

Centrifugal separator

Номер: US20120129673A1
Принадлежит: Hitachi High Technologies Corp

The weight difference is limited between buckets ( 17 ) mounted at respective symmetrical positions with respect to a centrifugal separation rotational center and examination of samples is continuously performed in the order in which they are received. In particular, when a sample ( 21 ) is carried in a centrifugal buffer line ( 11 ), its weight is measured by weight measuring means ( 31 ). It is assumed that the names of two adaptors ( 22 ) placed at respective symmetrical positions with respect to the centrifugal separation rotational center are defined as an adaptor A and an adaptor B. A first sample is put on the adaptor A and a second sample is put on the adaptor B. Then, a third sample and subsequent ones are each put on the adaptor ( 22 ) lighter than the other adaptor after the total weights of samples put on the adaptors are computation-compared with each other.

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31-05-2012 дата публикации

Article conveying system and sample processing system

Номер: US20120133492A1
Принадлежит: Hitachi High Technologies Corp

An object of the present invention is to provide a sample processing system, wherein writing to each RFID is equalized to eliminate unevenness in the use of sample containers. The configuration of the present invention can be realized by controlling the numbers of times (write counts) data is written to RFIDs, and by skipping data writing according to frequencies in the use of sample containers. Setting use information (count) of each IC tag, and comparing the use information with an average value of the use of the IC tags, make it possible to limit the write counts, which enables the equalization of writing to the IC tags, thereby making it possible to uniform the use of the sample containers in the system.

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31-05-2012 дата публикации

Specimen processing system

Номер: US20120134895A1
Принадлежит: Hitachi High Technologies Corp

Disclosed is a specimen processing system that includes means 91 circularly disposed to carry a reaction vessel 2 used for separating and extracting desired substances from a specimen to be processed, a plurality of processing steps, executed as processing progresses along a transport line for the reaction vessel 2 on the transport means 91, for conducting various processes upon the specimen to be processed that is accommodated in the reaction vessel 2, suctioning and discharging means 94 that dispenses the specimen from a specimen container 1 supplied to the system, into the reaction vessel 2, and a filtering vessel section 2 b provided as a part of the reaction vessel 2. This system configuration allows realization of a rapid preprocessing system capable of reducing the number of disposable parts of a low carry-over type, suppressing a decrease in cost performance, operating with high collection efficiency, and employing compact devices.

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31-05-2012 дата публикации

Variable Volume Mixing and Automatic Fluid Management for Programmable Microfluids

Номер: US20120136492A1
Принадлежит: PURDUE RESEARCH FOUNDATION

A microfluidic arrangement including a fluid channel configured to receive a first fluid from a first inlet and a second fluid from a second inlet, and a mixer connected to the fluid channel, the mixer including a mixer channel configured to receive a volume of the first fluid and a volume of the second fluid from the fluid channel, the mixer channel defining a mixer capacity, wherein the mixer is (i) configured to mix the volume of the first fluid and the volume of the second fluid in order to provide a mixture of the first fluid and the second fluid when the combined volume of the first fluid and the second fluid is less than the mixer capacity, and (ii) further configured to mix the volume of the first fluid and the volume of the second fluid in order to provide a mixture of the first fluid and the second fluid when the combined volume of the first fluid and the second fluid is equal to the mixer capacity.

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07-06-2012 дата публикации

Method for producing a reagent container assembly and reagent container assembly

Номер: US20120141339A1
Принадлежит: Roche Diagnostics Operations Inc

Embodiments directed to a process for producing a reagent container assembly made of plastic and a reagent container assembly are disclosed. The process may comprise: assembling a group of particular reagent containers, and joining the reagent containers to form the reagent container assembly where at least two of the reagent containers are permanently joined together by at least one welding process.

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14-06-2012 дата публикации

Specimen processing device, specimen conveyance device, and specimen conveyance method

Номер: US20120148447A1
Автор: Hiroyuki Tanaka
Принадлежит: Sysmex Corp

A specimen processing device comprising: a specimen processing unit for processing specimens; a first conveyance mechanism for conveying specimens from a carry-in side towards a carry-out side on the opposite side of the carry-in side with respect to the specimen processing unit through a specimen supply position for supplying specimens to the specimen processing unit; a second conveyance mechanism for conveying specimens from the carry-in side towards the carry-out side without passing the specimen supply position; a first control device for controlling the first conveyance mechanism; and a second control device for controlling the second conveyance mechanism, is disclosed. A specimen conveyance device and a specimen conveyance method are also disclosed.

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14-06-2012 дата публикации

Automatic analyzer

Номер: US20120148450A1
Принадлежит: Individual

According to one embodiment, an automatic analyzer comprises a light source, a spectroscope, a photo detection unit, a storage unit, a selection unit, and a calculation unit. The storage unit stores photo detector identifiers related to photo detectors and wavelength band identifiers in association with each other. The selection unit selects a specific photo detector from photo detectors. The specific photo detector corresponds to a specific photo detector identifier associated with a wavelength band identifier of a wavelength band according to a measurement item of a sample. The calculation unit calculates an absorbance related to the measurement item based on a signal from the selected specific photo detector.

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14-06-2012 дата публикации

Diagnostic apparatus for organic sample analysis

Номер: US20120149039A1
Принадлежит: BTP TECNO Srl

A diagnostic apparatus for organic-sample analyses including a fluid sucking and ejecting device to enable suction and inner storage or ejection to the outside of the fluid, a feeding needle that can be secured to the sucking device including an inner channel for passage of the fluids and to be inserted into containers for intaking or ejecting a given amount of the fluid, an actuating device, including a carriage, to spatially move the carriage along three axes, the carriage being susceptible of connection with the sucking and ejecting device, a first replacement station to house a plurality of feeding needles of the disposable type and suitable to enable automatic fastening and removal of one of the disposable feeding needles to and from the sucking device connected to the carriage, and a second replacement station to allow automatic fastening and removal of a precision feeding needle to and from the carriage.

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21-06-2012 дата публикации

Liquid feeding system for microchip, sample detection device, and liquid feeding method for liquid feeding system for microchip

Номер: US20120156800A1
Принадлежит: KONICA MINOLTA INC

A liquid feeding system for a microchip performs: a first liquid feeding step in which a sample liquid in a sample liquid containing section is fed in the direction to a primary containing section via a reaction field; a second liquid feeding step in which, after the first liquid feeding step, the sample liquid is fed from the primary containing section in the direction to the reaction field; and a third liquid feeding step in which, after the second liquid feeding step, the feedings of the sample liquid from and to the reaction field and the primary containing section a rear side gas-liquid boundary face of the sample liquid in the first liquid feeding step and the front side and rear side gas-liquid boundary faces of the sample liquid in the second and third liquid feeding steps do not pass through the reaction field.

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28-06-2012 дата публикации

Drive assembly for robotic conveyor system

Номер: US20120163945A1
Принадлежит: Brooks Automation Inc

A storage and retrieval system is provided. The storage and retrieval system having a frame and a shuttle movable within the frame, the shuttle having a carriage extending at least partially between a top and bottom of the frame. At least one tension member extends between a first and second ends of the frame and is coupled to the shuttle. At least one drive member extends between the first and second ends of the frame and is coupled to the shuttle. The at least one drive member and the at least one tension member project from opposite sides of the shuttle towards respective first and second ends of the frame and effect stabilization of the carriage against at least rotation relative to the frame. The at least one tension member crosses the at least one drive member and the at least one drive member effects movement of the shuttle.

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28-06-2012 дата публикации

Sample Distribution

Номер: US20120164735A1
Принадлежит: Roche Molecular Systems Inc

A method is described for distributing samples within an automated analyzer from a linear arrangement of sample vessels to a processing plate in a two-dimensional n×m arrangement wherein samples are sorted, followed by transfer with a pipetting device with a linear arrangement to a processing vessel in a two-dimensional n×m arrangement and subsequent processing of samples using a second pipetting device which has a two-dimensional n×m arrangement.

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12-07-2012 дата публикации

Automated sample processing system

Номер: US20120174687A1
Принадлежит: Hitachi High Technologies Corp

After being dispensed, a sample that needs to be quickly measured passes through another unit and is transported to an automatic analyzer. A plurality of units are provided for functions of processing including a dispensing unit that dispenses the sample stored in a sample vessel into another sample vessel. At least one discharge line discharges the sample from the dispensing unit to a transport line and a line that is perpendicular to the discharge line. A reverse direction transport line transports the sample in a direction reverse to a direction in which the sample loaded in the system is transported to the dispensing unit. The sample that is processed by the dispensing unit is transported to a storage unit located on the upstream side of the system, through the reverse direction transport line.

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12-07-2012 дата публикации

Luer seal for solid phase extraction columns

Номер: US20120175368A1
Принадлежит: SPEWare Corp

Disclosed herein is a luer seal for sealing a bottom outlet of each of the wells or columns in a plurality of Solid Phase Extraction (SPE) wells or columns in an array, the luer seal comprising a flexible, substantially flat mat having a top surface and a bottom surface, the top surface having portions defining a plurality of female luer slip connectors spaced for receiving an open tip of at least one of the plurality of solid phase extraction wells or columns, and sealingly fastening thereto for preventing fluid flow through the open tip. Also disclosed is a luer seal extractor for removing the luer seal from the column tips substantially simultaneously.

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19-07-2012 дата публикации

Automatic analyzer

Номер: US20120183438A1
Принадлежит: Hitachi High Technologies Corp

The automatic analyzer includes: a first reagent container storage section storing a plurality of reagent containers; a regent dispensing mechanism for dispensing a reagent from a reagent container stored in the first reagent container storage section; a second reagent container storage section storing a plurality of reagent containers; a reagent container transfer mechanism for transferring a reagent container selected from among reagent containers stored in the second reagent container storage section to the first reagent container storage section; and a controller configured to control the reagent container transfer mechanism to transfer a reagent container from the second reagent container storage section to the first reagent container storage section on the basis of a predetermined priority condition. The predetermined priority condition is one of a reagent provided with an effective calibration curve result, a number of remaining tests, and an expiration date of a reagent.

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02-08-2012 дата публикации

Expert-system-based rheology

Номер: US20120192625A1
Принадлежит: Malvern Instruments Ltd

A rheometer is disclosed that includes rheometry logic that is responsive to a material selection control, to an objective selection control, to material property storage, and to process parameter storage, and is operative to assist the user with a measurement using the rheometer. In another general aspect, a rheometer includes sample history storage operative to store a history that spans a plurality of different operations performed by the rheometer on a same sample.

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02-08-2012 дата публикации

Apparatus and method for separating and isolating components of a biological fluid

Номер: US20120193274A1
Принадлежит: Individual

A device for separating and isolating components of a biological fluid comprising a container for containing the fluid to be processed, a tube cap assembly for closing the container while providing filling and extraction communication therewith, a float assembly disposed within the container for funneling and controlling biological fluid flow into an inverted domed shaped isolation chamber within the float and controlling the biological fluid flow out of the isolation chamber for effecting an encapsulation or a sealed isolation of at least one component or fraction of the biological fluid flow within the isolation chamber during a centrifugation process. The device further comprising a flexible tube for connecting an extraction passageway disposed within the float assembly and an extraction valve of the tube cap assembly for allowing extraction of at least the one component or fraction encapsulated or isolated within the chamber.

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02-08-2012 дата публикации

Slide Processing Apparatus and Method

Номер: US20120195497A1
Принадлежит: Thermo Shandon Ltd

A basket processing apparatus that includes a basket storage portion in a form of a horizontal load rail. A plurality of slide storage baskets can be located in series on the rail. Each basket is ‘side loading’ and the side loading aperture of each basket can be selectively covered by a slide retaining bar. When the baskets are placed on the load rail, the basket can be moved along the horizontal rail by a basket moving means. The arrangement of the rail and the basket moving means is such that the baskets can be pushed together and move as a ‘train’. Baskets moved to the pick-up end of the rail can then be removed from the rail and processed. A vertical lift mechanism can be used to remove the basket and transport it to a processing device, for example a coverslipper.

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02-08-2012 дата публикации

Reagent kit for analyzing apparatus

Номер: US20120195808A1
Принадлежит: Roche Diagnostics Operations Inc

A reagent kit is provided comprising a plurality of containers with top-side openings, a common support structure or a plurality of support structures associated to the containers, and a plurality of caps. Each container and cap is mountable or provided on the common or the associated support structure, wherein each cap is formed essentially rectangular, having two shorter edges and two longer edges, and comprises: a cap body, a lid hinged to the cap body so to pivot around a pivot axis at least between closed and opened positions, the pivot axis being essentially parallel to the shorter edges. The containers and associated caps are arranged in a row along a connecting line such that the pivot axes are orthogonal to the connecting line. For at least one of the containers, an end portion of the cap body opposite to the pivot axis is not covered by the lid.

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02-08-2012 дата публикации

Sample analyzer and sample container supplying apparatus

Номер: US20120195812A1
Принадлежит: Sysmex Corp

A sample analyzer for analyzing a sample comprising: a sample container receiver capable of receiving either one of a manually supplied sample container and an automatically supplied; a container holder receiver for receiving a container holder holding at least one sample container; a sample container supplier automatically for supplying, to the sample container receiver, a sample container held by the container holder received by the container holder receiver; an aspirator for aspirating a sample within a sample container received by the sample container receiver; and an analyzing part for analyzing the sample aspirated by the aspirator.

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02-08-2012 дата публикации

Devices and method for enrichment and alteration of cells and other particles

Номер: US20120196273A1
Принадлежит: Individual

The invention features devices and methods for the deterministic separation of particles. Exemplary methods include the enrichment of a sample in a desired particle or the alteration of a desired particle in the device. The devices and methods are advantageously employed to enrich for rare cells, e.g., fetal cells, present in a sample, e.g., maternal blood and rare cell components, e.g., fetal cell nuclei. The invention further provides a method for preferentially lysing cells of interest in a sample, e.g., to extract clinical information from a cellular component, e.g., a nucleus, of the cells of interest. In general, the method employs differential lysis between the cells of interest and other cells (e.g., other nucleated cells) in the sample.

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16-08-2012 дата публикации

Control of operation conditions within fluidic systems

Номер: US20120204964A1
Принадлежит: Caliper Life Sciences Inc

The invention provides methods of controlling environmental conditions within a fluidic system, where such environmental conditions can affect the operation of the system in its desired function, and fluidic channels, devices, and systems that are used in practicing these methods. Such methods are generally directed to environmental control fluids, the movement of such fluids through these systems, and the interaction of these fluids with other components of the system, e.g., other fluids or solid components of the system.

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06-09-2012 дата публикации

Apparatus and method for separation of liquid phases of different density and for fluorous phase organic syntheses

Номер: US20120223025A1
Автор: Michal Lebl
Принадлежит: Illumina Inc

A simple, efficient apparatus and method for separating layers of immiscible or partially miscible liquids useful in methods of high-throughput combinatorial organic synthesis or parallel extraction of large libraries or megaarrays of organic compounds is disclosed. The apparatus and method are useful, whether as part of an automated, robotic or manual system for combinatorial organic synthesis or purification (extraction). In a preferred embodiment, an apparatus and method for separating layers of immiscible or partially miscible liquids compatible with microtiter plate type array(s) of reaction vessels is disclosed. Another application of centrifugation based liquid removal was found for washing the plates in biological assays or synthesis on modified substrates.

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06-09-2012 дата публикации

Stack of test strips and method for the production thereof

Номер: US20120224996A1
Автор: Herbert Harttig
Принадлежит: Roche Diagnostics Operations Inc

A stack of test strips comprises individual test strips which are stacked over each other and carry a test field for examining a bodily fluid sample. Test strips lying one on top of the other are detachably adhesively bonded to each other so that the test strips can be individually removed from the stack, wherein the test fields are packed in chambers and adjacent test strips form the bottom and the lid of such a chamber. A method for producing such a stack of test strips is also disclosed.

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13-09-2012 дата публикации

Devices and methods for interfacing microfluidic devices with macrofluidic devices

Номер: US20120230887A1
Автор: Piero Zucchelli
Принадлежит: SpinX Inc

The present disclosure is directed generally to devices and methods with the purpose of interfacing microfluidic devices with macrofluidic devices. Specifically, the present disclosure includes the de-

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13-09-2012 дата публикации

Temperature control system

Номер: US20120230888A1
Принадлежит: Aida Engineering Ltd, NEC Corp

For heating or cooling a sample contained in a vessel portion through a heat transfer member held in contact with the vessel portion, there is used the vessel portion, which has a part formed of an elastic member, expands and contracts for injection and discharge of the sample, is closed other than a connecting port with a channel connected to the vessel, and expands and contracts for injection and discharge of the sample. The vessel portion expands correspondingly to the injection when the sample is injected through an inflow path serving as the channel into the vessel portion contracting in a non-contacting state with the heat transfer member. A predetermined amount of sample is injected into the vessel portion so as to expand the vessel portion, and the vessel portion comes into contact with the heat transfer member. The vessel portion is heated or cooled through the heat transfer member.

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20-09-2012 дата публикации

Automatic analyzing device

Номер: US20120239676A1
Принадлежит: Hitachi High Technologies Corp

In order to improve work efficiency, to exclude human mistakes, and to improve analysis efficiency, an automatic analyzing device that analyzes blood and urine includes a bar code reader and an RFID reader that reads identification information relating to the samples and reagents and that is installed in an operating unit for managing analyzing units in an integrated manner. Test information is stored in a test information storage means of the operating unit and when the identification information stuck on containers of the samples or the reagents is read, the test information is searched. The test information is displayed on a screen of the operating unit as search results; and a function of switching from the search results displayed on the screen to a detailed screen that displays details of the test information when a user selects target test information is provided.

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04-10-2012 дата публикации

Methods and devices for nucleic acid purification

Номер: US20120252115A1
Принадлежит: Individual

The invention provides pipette tip columns and automated methods for the purification of nucleic acids such as plasmids from unclarified cell lysates containing cell debris as well as methods for making and using such columns. The columns typically include a bed of medium positioned in the pipette tip column, above a bottom frit and with an optional top frit.

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11-10-2012 дата публикации

Pipetting device

Номер: US20120258026A1
Автор: Uwe Naumann
Принадлежит: CYBIO AG

The invention relates to a sealing assembly for a metering device, in particular a multi-channel metering device. The sealing assembly serves to seal pipette tips with respect to the metering device. A multi-channel metering device comprises a multiplicity of openings arranged in one plane. A sealing plate with holes in the grid of the openings abuts this plane. Each pipette tip is provided with an annular collar which has an abutting face and is pressed against the sealing plate by force closure so as to enclose one hole.

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11-10-2012 дата публикации

Rack for sample tubes and reagent holders

Номер: US20120258463A1
Принадлежит: HandyLab Inc

A rack for holding samples and various reagents, wherein the rack may be used for loading the samples and reagents prior to using the reagents. The rack accepts complementary reagent holders, each of which contain a set of reagents for carrying out a predetermined processing operation, such as preparing biological samples for amplifying and detecting polynucleotides extracted from the samples.

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25-10-2012 дата публикации

Sample conveying system

Номер: US20120266698A1
Принадлежит: Hitachi High Technologies Corp

Conventional conveying lines have required building according to the particular shapes of test tube racks and test tube holders. For this reason, at least two types of dedicated lines, one for test tube racks and one for test tube holders, have been needed in one system, so there has been a tendency for systems to be complex in structure and disadvantageous in cost. To solve these problems, this invention provides a sample conveying system designed so that test tube racks and test tube holders can move on the same line, and high in both cost-effectiveness and reliability.

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01-11-2012 дата публикации

Data management computer, sample analyzing system, and computer program

Номер: US20120272755A1
Принадлежит: Sysmex Corp

A data management computer for a sample measuring apparatus is disclosed. The computer comprises a data storage, a display section; an input device; and a controller. The data storage stores results of measurements for a sample obtained by the sample measuring apparatus, the measurements including an initial measurement for a sample and a secondary measurement which is performed on the sample following the initial measurement. The controller is programmed to cause the display section to display a first result screen which shows a result of the initial measurement for a sample, receive a predefined operation by use of the input device while displaying the first result screen, and cause the display section to display, in a response to the predefined operation, a second result screen which shows a result of the secondary measurement for the sample.

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08-11-2012 дата публикации

Automated analyzer for clinical laboratory

Номер: US20120282684A1
Принадлежит: ABBOTT LABORATORIES

A laboratory automation system that is capable of carrying out clinical chemistry assays, immunoassays, amplification of nucleic acid assays, and any combination of the foregoing, said laboratory automation system employing at least one of micro-well plates and deep multi-well plates as reaction vessels. The use of micro-well plates as reaction vessels enables the laboratory automation system to assume a variety of arrangements, i.e., the laboratory automation system can comprise a variety of functional modules that can be arranged in various ways. In order to effectively carry out immunoassays by means of micro-well plates, a technique known as inverse magnetic particle processing can be used to transfer the product(s) of immunoassays from one micro-well of a micro-well plate to another.

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15-11-2012 дата публикации

System for handling slides having a linear transport mechanism for transporting the racks

Номер: US20120290127A1
Принадлежит: LEICA BIOSYSTEMS NUSSLOCH GMBH

The present invention relates to a system ( 10, 100 ) for handling slides, including an input compartment ( 14 ) for inputting racks ( 16 ) and the slides held therein, and a coverslipper module ( 30, 32 ) for coverslipping slides. The system ( 10, 100 ) further includes an output compartment ( 22 ) for outputting racks ( 16 ), a transport unit ( 20 ) for transporting the racks ( 16 ), and a control unit ( 52 ) for controlling the transport unit ( 20 ). The transport unit ( 20 ) is designed to be capable of transporting the racks ( 16 ) between the input compartment ( 14 ), the coverslipper module ( 30, 32 ) and the output compartment ( 22 ).

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22-11-2012 дата публикации

Instrument And Method For The Automated Thermal Treatment Of Liquid Samples

Номер: US20120295249A1
Принадлежит: Roche Diagnostics Operations Inc

An instrument and a method for the automated thermal treatment of liquid samples are disclosed. An inter-distance between a temperature-controlled receptacle for loading with a plurality of vessels for containing the samples and end portions of optical fibers can be varied, wherein the receptacle is configured to form a thermal communication with the loaded vessels and wherein the optical fibers have first and second end portions. The first end portion and the second end portion of each optical fiber is fixed with respect to each other for transmitting light, wherein the variation of the inter-distance allows the vessels to be loaded to or unloaded from the receptacle and to enable detection of light from the samples contained in the one or more receptacle-loaded vessels.

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06-12-2012 дата публикации

Universal container capper/decapper

Номер: US20120304597A1
Автор: Sergey Mikhailov
Принадлежит: Dynacon Inc

A universal container capper/decapper includes a capper/decapper assembly, and an axial actuator. The capper/decapper assembly comprises a capper/decapper housing, and at least one gripper arm. The capper/decapper housing has an axis of rotation. Each gripper arm has a driven end, a gripper end, and a knee portion intermediate the driven end and the gripper end. Each gripper arm is pivotally coupled to the housing proximate the knee portion. The axial actuator is coupled to each driven end and is configured to drive each gripper end in a radial direction relative to the axis of rotation by rotating each gripper arm about the respective knee portion relative to the housing.

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06-12-2012 дата публикации

Method and Device for Testing a Capacitively Operating Measuring Device, Which Is Designed for the Detection of Phase Boundaries, and Correspondingly Equipped Laboratory Apparatus

Номер: US20120304732A1
Принадлежит: TECAN TRADING AG

A device has at least one channel for detecting the phase boundary between media in a liquid container and has a probe which can be fed in the direction of the phase boundary and a circuit which processes a signal of the probe to detect a capacitance change. The device includes a testing module which executes an infeed movement of the probe. The testing module performs an analysis of the signal of the channel, and makes a connection statement about the electrical connection between the probe and the measuring circuit. The testing of the electrical connections is performed in a dry manner, i.e., a phase boundary does not have to be searched for or penetrated for the testing.

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06-12-2012 дата публикации

System, apparatus, and method for closed tube sampling and open tube sampling for automated clinical analyzers

Номер: US20120308435A1
Автор: Patrick P. Fritchie
Принадлежит: ABBOTT LABORATORIES

A centrifuge to which sample tubes can be introduced while the centrifuge is in motion. The centrifuge comprises a carousel having an upper portion and a lower portion. The upper portion of the carousel has a plurality of positions for sample tubes for a centrifugation operation, a plurality of drive mechanisms attached to the upper portion of the carousel, a movable element mounted upon each drive mechanism, the movable element capable of traversing the length of the drive mechanism when the drive mechanism is actuated, a sample tube-holding assembly comprising a sample tube holder and a bearing attached to each movable element, and at least one balancing element capable of contributing to a force vector that cancels an imbalance vector generated by rotation of the centrifuge.

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06-12-2012 дата публикации

Automatic analyzing device

Номер: US20120309099A1
Принадлежит: Hitachi High Technologies Corp

Provided is an automatic analyzing device including a sample container 2 for accommodating a sample 1 to be assayed, a dispensing probe 5 for dispensing the sample 1 , and an electroconductive tip 11 removably mounted on a portion of the dispensing probe 5 , the portion being to be dipped in the sample 1 ; wherein this analyzing device detects capacitance between the tip 11 of the dispensing probe 5 and a region having a ground potential 9 predefined as a reference electric potential in the analyzing device, and on the basis of a result of the detection, determines a mounted state of the tip 11 on the dispensing probe 5 . A fall of the tip from the probe is thus immediately detected.

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06-12-2012 дата публикации

Biosample plate with data storage and wireless communication means

Номер: US20120309111A1
Принадлежит: International Business Machines Corp

Embodiments of the disclosure relate to a biosample plate that includes a memory component for storing information related to the biosample, biosample plate and biosample analysis data, and a wireless communication interface for transferring information to and from the biosample plate. The biosample plate may be used with an analyzing and data recording system such as an electromagnetic tape drive. The disclosed biosample plate facilitates the correlation between a large number of biosample plates and data as data remains with the corresponding biosamples both when the biosample plates are in use and when they are in storage. The wireless communication interface may comprise an antenna disposed in a biosample plate for data transmission to and from the biosample plate by radio signals.

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13-12-2012 дата публикации

Imaging system and techniques

Номер: US20120312957A1
Принадлежит: BioImagene Inc, Ventana Medical Systems Inc

Systems and techniques for an optical scanning microscope and/or other appropriate imaging system includes components for scanning and collecting focused images of a tissue sample and/or other object disposed on a slide. The focusing system described herein provides for determining best focus for each snapshot as a snapshot is captured, which may be referred to as “on-the-fly focusing.” The devices and techniques provided herein lead to significant reductions in the time required for forming a digital image of an area in a pathology slide and provide for the creation of high quality digital images of a specimen at high throughput.

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20-12-2012 дата публикации

Instrument and Method for Clinical Examinations and Cleaning Method Therefor

Номер: US20120318302A1
Автор: Yoshiyuki Nakayama
Принадлежит: Jeol Ltd

An automated clinical analyzer and method is offered which can clean the nozzles of a reaction cuvette wash unit. A first detergent is put in first reagent containers located on a first reagent turntable. A computer controller drives a first reagent pipette to aspirate the detergent from the first reagent containers and to deliver the detergent into reaction cuvettes. The controller drives a reaction turntable to bring each reaction cuvette holding the detergent therein to the reaction cuvette wash unit. The controller drives the reaction cuvette wash unit to aspirate the detergent from inside the reaction cuvettes using reaction cuvette wash nozzles to thereby clean the wash nozzles. A second detergent is then used to clean the nozzles.

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20-12-2012 дата публикации

Analysis device and reagent container

Номер: US20120321513A1
Принадлежит: Sysmex Corp

An analysis device for particle analysis, configured in such a manner that a reagent container is set in the device by inserting the reagent container from a side surface of the device toward the inside thereof, the reagent container having, near the forward end thereof, a suction pipe entrance portion into which a suction pipe can enter. The analysis device is provided with: a reagent container holding portion which holds the reagent container inserted from the suction pipe entrance portion side; and the suction pipe which enters, from above, the suction pipe entrance portion of the reagent container held by the reagent container holding portion and which sucks a reagent within the reagent container. The reagent container holding portion includes a guide member for guiding the insertion of the reagent container, which is inserted from the suction pipe entrance portion side, into the reagent container holding portion.

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27-12-2012 дата публикации

Method of Pre-Treatment and Staining of a Biological Sample and Device for Support of a Biological Sample and Methods of Using Such Device

Номер: US20120330564A1
Принадлежит: DakoCytomation Denmark AS

There is disclosed a method of pre-treatment and staining, according to a protocol, of a biological sample disposed upon the surface of a carrier, the method comprising the step of recording at least one parameter relating to at least one protocol step in a non-volatile memory located either upon or within the carrier or a device incorporating the carrier. Also disclosed is a device comprising: a non-volatile memory; a surface of the device adapted to carry a biological sample; and communications means electrically coupled to the memory for enabling data transmission to or from an external apparatus. Also disclosed is a method of controlling processing of a biological sample disposed upon a carrier, comprising: providing, upon or within the carrier or an apparatus holding the carrier, a non-volatile memory having information relating to sample processing priority or protocol; reading the information; and scheduling the processing based upon the information.

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03-01-2013 дата публикации

Systems and methods for sample display and review

Номер: US20130002847A1
Принадлежит: Constitution Medical Inc

Methods and systems for displaying images of cells in a sample include obtaining a plurality of images of cells in the sample, where each image corresponds to one of the cells in the sample, determining values of at least one property for each of the cells based on the plurality of images, arranging the plurality of images to form a first image array, where the images are ordered in the first image array based on the values of the at least one property, displaying the first image array, sorting the plurality of images to form a second image array in which an ordering of the images is different from the first image array, and displaying the second image array, where the sample includes blood and the cells include red blood cells.

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03-01-2013 дата публикации

Holder for Culture Plates with De-Nesting Feature

Номер: US20130004287A1
Принадлежит: Biomerieux Inc

A holding structure for holding a plurality of culture plates in a stacked arrangement includes a feature for de-nesting the bottom culture plate from the plate above it. The de-nesting feature is preferably a structure which urges a plate to move laterally relative to the plate above it. The de-nesting of the bottom culture plate from the adjacent culture plate facilitates withdrawal of the bottom culture plate from the base via a robotic plate transfer mechanism. The de-nesting feature can be entirely passive, such as ramps formed in the base of the holding structure.

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03-01-2013 дата публикации

Apparatus and method for processing biological material

Номер: US20130005032A1
Принадлежит: Baxter International Inc

The application discloses an apparatus and method for processing biological material, including a suspension of cells.

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10-01-2013 дата публикации

Modular sample store

Номер: US20130011226A1
Принадлежит: Brooks Automation Inc

A modular sample storeincluding a storage area; a service area; a transfer area; a motorized robot with a lifting device and at least one platform; and a controller. The sample store service area includes one integrally formed cubic vat module and the sample store storage area includes at least one integrally formed cubic vat module. Each one of the aforementioned vat modules includes an essentially horizontal vat floor and four joining vat walls that are connected to the vat floor and that are leaving an open vat space. The modular sample store also includes upper side walls and a cover plate to close the sample store. Each vat floor and vat wall includes an outside liner and an inside liner, which outside and inside liners in each case are separated by a clearance. This clearance is essentially filled with a polymer foam material that provides fixation of the outside and inside liners to each other as well as thermal insulation of and reinforcement to the thus integrally formed cubic vat module sandwich construction.

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17-01-2013 дата публикации

Bioprinting station, assembly comprising such bioprinting station and bioprinting method

Номер: US20130017564A1

Bioprinting station (1) comprising:—a Bioprinting device (4) adapted to deposit a pattern of biological material (2) onto an area of interest (3 a ) of a substrate (3),—an imaging system (15) adapted to acquire an image of the substrate (3) and to reveal on the acquired image the area of interest (3 a ) with respect to a remaining part (3 b ) of the substrate (3), the acquired image of the substrate (3) being processed so as to detect the revealed area of interest (3 a ) on the acquired image and to determine the pattern corresponding to the area of interest (3 a ) detected on the acquired image.

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17-01-2013 дата публикации

Analytical apparatus and detection method employed in analytical apparatus

Номер: US20130017595A1
Принадлежит: Hitachi High Technologies Corp

Disclosed is an analytical apparatus wherein a container is automatically transferred and the container is automatically closed with a cap member, said analytical apparatus being provided with a suitable mechanism that reliably closes the container. The analytical apparatus is provided with an optical sensor composed of at least one pair of a light source ( 4 ) and a light detector ( 5 ), which face each other with the container disposing position therebetween, and which are disposed such that the container disposing position is irradiated with light, and the analytical apparatus detects whether the container ( 1 ) is disposed or not or the absence/presence of the cap of the container, corresponding to a transmitted light quantity detected by means of the optical sensor. Thus, cap closing is prevented from being performed if there is no container, and the container is prevented from being transferred without the cap.

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07-02-2013 дата публикации

Biological sample-processing apparatus having a door with space for receiving reagent tanks

Номер: US20130034476A1
Автор: David Daf
Принадлежит: Taigen Bioscience Corp

A biological sample-processing apparatus has a sample-processing chamber, which has a door with space for receiving reagent tanks. The reagent supply tanks have conduits in fluid communication with reagent buffer tanks in the sample-processing chamber. The door has a pivot with a hollow interior. At least one conduit connects the reagent supply tanks to the reagent buffer tanks through the hollow interior of the pivot. The present invention provides a modification of the door of a biological sample-processing apparatus so that the door is equipped with reagent supply tanks that contain reagents for processing biological samples and that facilitate the operation of the processing and increase convenience, and further, enable more of the apparatuses to be allocated in the same space.

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07-02-2013 дата публикации

System and Method for the Continuous Extraction of a Liquid Phase of Microsamples, and Automated Installation for Taking Them, For Carrying Out the Extraction and Taking Measurements

Номер: US20130035223A1

A continuous automated extraction system and method for physically extracting at least one liquid phase of a series of liquid microsamples which are taken beforehand in discrete packets, both in space and in time, and are in stored is provided. The method may include an extraction system having a centrifuge provided with a plurality of microholders, at least one of which is filled with the corresponding microsample and includes a filling upper portion that is extended by a separating lower portion of smaller cross section than that of the upper portion. Each filled microholder has a mass which is more than ten times the mass of this microsample, in such a way that it is possible to extract, by centrifugation, at a given instant, only a single microsample contained in a single microholder, or several microsamples contained in some or all of these microholders, progressively as the latter are filled.

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14-02-2013 дата публикации

Apparatus for and method of processing biological samples

Номер: US20130040376A1
Принадлежит: Life Technologies Corp

The present invention provides systems, devices, apparatuses and methods for automated bioprocessing. Examples of protocols and bioprocessing procedures suitable for the present invention include but are not limited to: immunoprecipitation, chromatin immunoprecipitation, recombinant protein isolation, nucleic acid separation and isolation, protein labeling, separation and isolation, cell separation and isolation, food safety analysis and automatic bead based separation. In some embodiments, the invention provides automated systems, automated devices, automated cartridges and automated methods of western blot processing. Other embodiments include automated systems, automated devices, automated cartridges and automated methods for separation, preparation and purification of nucleic acids, such as DNA or RNA or fragments thereof, including plasmid DNA, genomic DNA, bacterial DNA, viral DNA and any other DNA, and for automated systems, automated devices, automated cartridges and automated methods for processing, separation and purification of proteins, peptides and the like.

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21-03-2013 дата публикации

Microfluidic device

Номер: US20130071304A1
Автор: Byung Hee Jeon
Принадлежит: Cytogen Inc

A micro-fluidic device includes a filter cabinet, a first filtering unit and a second filtering unit. The filter cabinet includes a first path and a second path branched from the first path. The first path and the second path are formed within the filter cabinet so that a sample containing different kinds of targets can flow through the first path and the second path. The first filtering unit is installed in an upstream portion of the first path to filter the different kinds of targets from the sample, the first filtering unit configured to guide the different kinds of targets toward the second path. The second filtering unit is installed in the second path to receive the different kinds of targets from the first filtering unit and to filter the different kinds of targets on a size-by-size basis.

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21-03-2013 дата публикации

Moving microdroplets in a microfluidic device

Номер: US20130071851A1
Принадлежит: HandyLab Inc

The present invention relates to a system and method for moving samples, such as fluid, within a microfluidic system using a plurality of gas actuators for applying pressure at different locations within the microfluidic. The system includes a substrate which forms a fluid network through which fluid flows, and a plurality of gas actuators integral with the substrate. One such gas actuator is coupled to the network at a first location for providing gas pressure to move a microfluidic sample within the network. Another gas actuator is coupled to the network at a second location for providing gas pressure to further move at least a portion of the microfluidic sample within the network. A valve is coupled to the microfluidic network so that, when the valve is closed, it substantially isolates the second gas actuator from the first gas actuator.

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28-03-2013 дата публикации

Sample analyzer and method for controlling sample analyzer

Номер: US20130078617A1
Принадлежит: Sysmex Corp

A sample analyzer transports a first rack and a second rack, the first rack including a first number of supporters for supporting containers that contain biological samples of subjects, and the second rack including a second number of supporters for supporting containers that contain standard samples. The sample analyzer determines whether a transport object is the first rack or the second rack. When it has been determined that the transport object is the second rack, the sample analyzer performs a transporting operation according to the second rack and measure the standard samples in the containers supported by the second rack in a predetermined order, and prepares a calibration curve used for analyzing a measurement result of a biological sample, based on a plurality of measurement results of the standard samples.

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28-03-2013 дата публикации

Method And Devices For The Cross-Referencing Of Identification Of Tissue Slice Supports For Microtomised Analytical Samples

Номер: US20130078669A1
Автор: Hans L. Heid, Jose Novoa
Принадлежит: MICROM INTERNATIONAL GMBH

The invention relates to a method and device for the cross-referencing of identification ( 1 ) of tissue slice supports ( 2 ), for microtomised analytical samples still to be mounted thereon, with identification information ( 3 ) of a tissue sample holder ( 4 ) of a tissue sample ( 5 ) which is not yet microtomised. The conventional problem of cross-referencing is improved in a simple manner, whereby the identification information ( 3 ) for the tissue sample holder ( 4 ) is automatically detected when positioned in the microtome ( 6 ) and an identification ( 1 ) corresponding thereto is automatically transferred to at least one tissue slice support ( 2 ) and that tissue slice support ( 2 ), provided with the identification ( 1 ), is dispensed for application of the tissue sample slice at the moment when a tissue sample slice must be applied to a tissue slice support ( 2 ).

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28-03-2013 дата публикации

Systems and methods for multi-analysis

Номер: US20130079236A1
Автор: Elizabeth Holmes
Принадлежит: Theranos Inc

Systems and methods are provided for sample processing. A device may be provided, capable of receiving the sample, and performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing multiple assays. The device may comprise one or more modules that may be capable of performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing the steps using a small volume of sample.

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04-04-2013 дата публикации

System and Method for Monitoring Time Intervals During Blood Parameter Monitoring

Номер: US20130085471A1
Принадлежит: B Braun Melsungen AG

A system and method for monitoring at least one blood parameter of the blood of different patients, comprising a plurality of access devices for establishing at least one means of access to the blood of each patient through the skin, a plurality of removal devices for removing a quantity of blood from each patient in order to obtain at least one blood sample, at least one blood analysis device for analysing the blood sample with respect to predeterminable blood parameters and for generating individual blood parameter data sets, a calculation device which can be used jointly for a plurality of blood parameter data sets of different patients for calculating data sets of drug parameters of the drugs to be administered to the respective patient on the basis of the individual blood parameter data sets, and a plurality of supply devices for supplying the respective drug having the calculated drug parameters.

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11-04-2013 дата публикации

Fluid controlling apparatus and method of controlling fluid by using the same

Номер: US20130086998A1
Принадлежит: SAMSUNG ELECTRONICS CO LTD

A fluid controlling apparatus including at least one sample chamber for holding a fluid containing target materials; a cleaning chamber for holding a cleaning solution; a first multi-port connected to the at least one sample chamber through a first channel and connected to the cleaning chamber through a second channel; a filter portion, connected to the first multi-port through a third channel, for filtering the target materials; and a first pump, connected to the filter portion, for applying a pressure; and a method of controlling a fluid using the fluid controlling apparatus, which comprises passing the fluid containing the target materials from the at least one sample chamber to the filter portion; and cleaning a path of the fluid by passing the cleaning solution through the path.

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09-05-2013 дата публикации

Tip for pipetting device including a part capable of protecting said device

Номер: US20130112015A1
Автор: Frédéric FOUCAULT
Принадлежит: bioMerieux SA

A tip capable of being fitted onto the body of a device for pipetting a liquid including a distal part intended for receiving the liquid sampled by the pipetting device, said distal part having a free distal end via which the liquid is aspirated and discharged, a middle part, joined to the distal part, intended to come into contact, via its free proximal end, with the body of said pipetting device and make it possible for said tip to be fixed on said body, a proximal part joined to the middle part and passed through by the body of said pipetting device when said tip is fitted on said body, said proximal part being intended for protecting said body and preventing any contact between the pipetting device and the liquid, said tip being characterized in that the proximal part is not in contact with the body of the pipetting device.

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16-05-2013 дата публикации

Reagent bottles, valves therefor, washing modules and methods and apparatus for dispensing reagents

Номер: US20130121878A1
Принадлежит: Randox Laboratories Ltd

A valve for a reagent bottle is provided, the valve including a resilient membrane configured to extend across an opening in the reagent bottle, the resilient membrane having at least one slit extending therethrough. Also disclosed is a dispensing apparatus for dispensing a reagent from a reagent bottle, the dispensing apparatus comprising: a probe assembly having a probe adapted for insertion into the reagent bottle through the valve and an extraction mechanism for drawing reagent out of the reagent bottle through the probe. A valve opening assembly is provided, which is adapted to open the valve of the reagent bottle such that the probe can pass through the valve without contacting the valve.

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16-05-2013 дата публикации

Automatic analyzer

Номер: US20130121880A1
Автор: Isao Yamazaki
Принадлежит: Hitachi High Technologies Corp

Dispensing failure occurs when air-sucking or clogging is caused at the time of sucking sample or reagent by using a dispensing probe. An automatic analyzer is equipped with a dispensing mechanism ( 15 ) for dispensing the sample into a reaction container ( 35 ) from a reagent container ( 10 ) and an analysis means ( 61 ) for analyzing contents within the reaction container ( 35 ), wherein the dispensing mechanism ( 15 ) includes a pressure generation mechanism ( 69 ) for changing the pressure within a nozzle and a dispensing flow path ( 24 ) for coupling between the nozzle and the pressure generation mechanism ( 69 ) and containing pressure transmission medium therein; and further includes an oscillator ( 27 ) for applying vibration of a particular frequency to the pressure transmission medium within the flow path, a pressure sensor ( 26 ) for detecting the pressure within the flow path, and a mechanism ( 76 ) for detecting whether or not the sample is sucked normally into the nozzle based on the amplitude or the phase difference of the component of the particular frequency extracted from the output of the pressure sensor ( 26 ).

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23-05-2013 дата публикации

Aliquotter system and workflow

Номер: US20130125675A1
Принадлежит: Beckman Coulter Inc

A method is disclosed. The method includes aspirating an aliquot volume of a sample in a primary sample container located in an aspiration position in an aliquotter module, and dispensing the aliquot volume of the sample in a secondary sample container located in a dispensing position in the aliquotter module. The method also includes the step of causing the secondary sample container to leave the aliquotter module before the primary sample container.

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23-05-2013 дата публикации

Body fluid testing device

Номер: US20130131480A1
Принадлежит: Roche Diagnostics Operations Inc

Body fluid testing device for analyzing a body fluid comprises a test media tape adapted to collect the body fluid. The test media tape comprises a tape and test media portions. A free tape portion without test medium is located between successive test media portions. The testing device further comprises a supply portion. The supply portion comprises a housing in which uncontaminated test media tape is contained. The housing further has an opening for withdrawing test media tape from the housing. The testing device further has a sealing means for closing the opening against the surrounding. A free tape portion of the test media tape is located between a wall of the housing and the sealing means when the sealing means closes the opening. Further aspects concern a test media cassette with sealing means and a method for providing test media while holding them sealed against humidity during onboard storage.

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23-05-2013 дата публикации

Chromatography configuration interface

Номер: US20130132897A1
Принадлежит: Bio Rad Laboratories Inc

Systems and methods that facilitate the setup and visualization of a configurable process, for example a chromatography experiment to be conducted using a configurable chromatography system. A user interface displays category regions representing sections of a process, and displays a plurality of selectable items representing components appropriate for placement in the category regions. A user interface control causes selection of one of the selectable items and placement of the selected item into one of the category regions, to define a selected process configuration. The user interface control may be a scrolling control that causes a set of selectable items appropriate for placement in the respective category region to scroll through the category region. When the computer displaying the user interface is also connected to the system being configured, the user interface may also facilitate setup, monitoring, and control of the resulting process.

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30-05-2013 дата публикации

System and method including analytical units

Номер: US20130137110A1
Автор: Charles S. Kraihanzel
Принадлежит: Beckman Coulter Inc

Systems and methods for processing and analyzing samples are disclosed. The system may process samples, such as biological fluids, using assay cartridges which can be processed at different processing locations. In some cases, the system can be used for PCR processing. The different processing locations may include a preparation location where samples can be prepared and an analysis location where samples can be analyzed. To assist with the preparation of samples, the system may also include a number of processing stations which may include processing lanes. During the analysis of samples, in some cases, thermal cycler modules and an appropriate optical detection system can be used to detect the presence or absence of certain nucleic acid sequences in the samples. The system can be used to accurately and rapidly process samples.

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20-06-2013 дата публикации

Gas Chromatograph Column Markings to Determine Length

Номер: US20130152666A1
Автор: Scott T. Quarmby
Принадлежит: Thermo Finnigan LLC

A gas chromatograph column is marked with a code that allows an operator or machine to accurately determine the distance between two points on the column by comparing markings at the two points on the column. The code may be human or machine readable.

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20-06-2013 дата публикации

Method for producing an analytical consumable

Номер: US20130153152A1
Принадлежит: Roche Diagnostics Operations Inc

A method for producing an analytical consumable is proposed. The analytical consumable comprises at least one carrier and at least one analytical aid connected to the carrier. At least one optically sensitive material is applied to the carrier, said material being designed to carry out at least one optically detectable alteration in the event of action of an electromagnetic radiation. In at least one coding step, at least one function information item about the analytical consumable is introduced into the optically sensitive material by means of electromagnetic radiation. The function information item is designed to enable at least one analytical instrument to use the analytical consumable correctly.

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20-06-2013 дата публикации

Disease simulation system and method

Номер: US20130157238A1
Автор: Stephen J. Brown
Принадлежит: Robert Bosch Healthcare Systems Inc

A method of diabetes management including receiving a plurality of readings over time from an analyte sensor, processing each of the readings to generate analyte data, receiving information about external factors, using the analyte data to estimate an amount of medication to be dispensed from a single dose medication device based on the analyte data in combination with the external factors, and displaying an instruction to deliver the amount of medication.

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20-06-2013 дата публикации

Waste ramp for reagent cards

Номер: US20130157372A1
Принадлежит: Siemens Healthcare Diagnostics Inc

An automated analyzer for reagent cards having a leading end, a trailing end and a length between the leading end and the trailing end comprises a travel surface assembly having a card travel surface and an edge. A test analyzing mechanism is adjacent to the travel surface, and a waste receptacle is adjacent to the edge below the travel surface. The waste receptacle has a side and a waste cavity. A ramp member positioned below the travel surface has an end and a sloped surface, and is movable between an extended position where the sloped surface extends into the waste cavity, and a retracted position where the end is spaced from the side a distance greater than the length of the reagent card. A moving mechanism operably coupled with the ramp member is configured to move the ramp member between the extended position and the retracted position.

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27-06-2013 дата публикации

Reader Devices for Optical and Electrochemical Test Devices

Номер: US20130162981A1
Принадлежит: ABBOTT POINT OF CARE INC

This invention relates generally to devices and methods for performing optical and electrochemical assays and, more particularly, to devices having optical and electrochemical detectors and to methods of performing optical and electrochemical assays using such devices. The present invention is particularly useful for performing immunoassays and/or electrochemical assays at the point-of-care.

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27-06-2013 дата публикации

Particle monitoring with secure data logging

Номер: US20130166251A1
Принадлежит: Hach Co

A data logging monitoring instrument and related methods are described. One aspect provides a particle counting instrument, including: one or more sensors; a storage system; and a processing system coupled to the storage system, the processing system being configured to accumulate measurement data ascertained via the one or more sensors in the storage system into one or more log files; wherein the one or more log files are stored in a secure file format that is compatible with other non-particle counting instrument information processing device applications. Other embodiments are described.

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18-07-2013 дата публикации

Microfluidic devices

Номер: US20130183659A1
Принадлежит: Raindance Technologies Inc

The present invention provides novel microfluidic substrates and methods that are useful for performing biological, chemical and diagnostic assays. The substrates can include a plurality of electrically addressable, channel bearing fluidic modules integrally arranged such that a continuous channel is provided for flow of immiscible fluids.

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18-07-2013 дата публикации

Cell processing apparatus, sample preparation apparatus, and cell analyzer

Номер: US20130183747A1
Принадлежит: Sysmex Corp

A cell processing apparatus includes a storage container that contains liquid L including a biological sample; a filter that prevents a first cell C 1 in the biological sample from passing and allows a second cell C 2 having a smaller diameter than that of the first cell C 1 to pass; and a filtration cylinder for separating, in the storage container and via the filter, the liquid L into a first liquid L 1 mainly including the first cell C 1 and a second liquid L 2 mainly including the second cell C 2 . A measurement target cell filtered by the filter among other cells can be easily collected.

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18-07-2013 дата публикации

Apparatus, method and article to perform assays using assay strips

Номер: US20130183772A1
Принадлежит: GenPrime Inc

An assay system includes an optical imager to acquire high resolution images of assay strips (e.g., lateral flow immunochromatographic test strips) and performs image processing to identify individual assay strips and determine results for each assay strip, by quantifies the presence or absence of test signal line(s) and control signal line(s). Assay strips may be in a holder or carrier contained in a specimen container also holding a specimen. The assay system automatically logs all results and data to a database that stores a high resolution image of the original immunochromatographic assay, the values of test line(s) and control line(s), and the test result. A user interface directs an end user through operation.

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18-07-2013 дата публикации

Integrated Test Device for Optical Detection of Microarrays

Номер: US20130184188A1
Принадлежит: ABBOTT POINT OF CARE INC

This invention relates generally to devices and methods for performing optical and electrochemical assays and, more particularly, to testing devices having an optically readable microspot array and/or an electrochemical detector and to methods of performing microspot arrays and electrochemical assays using such devices. The present invention is particularly useful for performing immunoassays and/or electrochemical assays at the point-of-care.

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01-08-2013 дата публикации

Capillary dispenser

Номер: US20130195733A1
Автор: Adrian Siemers
Принадлежит: CYBIO AG

A capillary dispenser includes at least one plunger-cylinder unit having a cylinder module and a plunger module disposed together on an axis. The cylinder module has an inner cylinder that is pneumatically connected to at least one capillary. The plunger module includes a hollow plunger that is closable on one side and is movable in the inner cylinder along the axis between an upper end position and a lower end position of the plunger module.

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08-08-2013 дата публикации

Automatic slide loading device for micro array scanner and its methods of use

Номер: US20130203611A1
Принадлежит: CapitalBio Corp, TSINGHUA UNIVERSITY

An automatic slide loading device for microarray scanner comprises slide holders ( 1 ), a carrier device ( 2 ) and a positioning chamber ( 3 ), wherein the slide holder ( 1 ) can hold microarray slides ( 6 ) and the slide holder ( 1 ) is placed out of the scanning platform of the microarray scanner when the microarray scanner is in off work state, wherein the carrier device ( 2 ) is connected to the positioning chamber ( 3 ) and the carrier device ( 2 ) can load the slide holder ( 1 ) into the positioning chamber ( 3 ), wherein the positioning chamber ( 3 ) is placed above the scanning platform of the microarray scanner and is used to precisely locate the working surface of the microarray slides ( 6 ) in the slide holder ( 1 ).

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15-08-2013 дата публикации

System and method including analytical units

Номер: US20130209334A1
Принадлежит: Beckman Coulter Inc

Systems and methods for processing and analyzing samples are disclosed. The system may process samples, such as biological fluids, using assay cartridges which can be processed at different processing locations. In some cases, the system can be used for PCR processing. The different processing locations may include a preparation location where samples can be prepared and an analysis location where samples can be analyzed. To assist with the preparation of samples, the system may also include a number of processing stations which may include processing lanes. During the analysis of samples, in some cases, thermal cycler modules and an appropriate optical detection system can be used to detect the presence or absence of certain nucleic acid sequences in the samples. The system can be used to accurately and rapidly process samples.

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22-08-2013 дата публикации

Cell analyzer, cell processing apparatus, specimen preparing apparatus

Номер: US20130217110A1
Принадлежит: Sysmex Corp

The present invention provides a cell analyzer which comprises: a cell dispersion unit which causes aggregated cells in a biological specimen to be dispersed, through a shearing force applying process of applying a shearing force to the aggregated cells and an ultrasonic dispersion process of dispersing the aggregated cells, by using ultrasonic waves; a detection unit which detects characteristics information reflecting properties of the cells in the biological specimen on which the shearing force applying process and the ultrasonic dispersion process have been performed; and an analysis unit which analyzes the cells in the biological specimen, based on a detection result from the detection unit.

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29-08-2013 дата публикации

Mixing apparatus

Номер: US20130224089A1
Принадлежит: Arkray Inc

A mixing apparatus includes: a mixing container with a discharge port for discharging mixed liquid; a filter paper covering the discharge port to temporarily retain the liquid; a receiving unit with a waste liquid collecting portion for receiving a first liquid discharged from the discharge port through the filter paper, and a measuring portion for receiving a second liquid subjected to treatment different from treatment for the first liquid; and an operation portion for enabling selection between a first receiving state in which the waste liquid collecting portion receives the first liquid and a second receiving state in which the measuring portion receives the second liquid, and also for controlling the movement of the first liquid or the second liquid.

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29-08-2013 дата публикации

System and method for delta checking of biological samples

Номер: US20130226605A1

Methods of the invention automatically determine analytes and delta thresholds to use in delta checking patient data. The analytes and thresholds are determine from a populating specific set of patient data. Variance in analytes for multiple patient samples is determined. In additional, variance in intentionally mismatched patient samples is determined. The best analytes to differentiate between patients are determined along with delta thresholds. Preferred embodiments conduct evaluation with a multivariate delta threshold determination for ongoing testing of results from the patient. Preferred software provides an interactive interface that allows a user to set a number of flags that can be handled per a predetermined time period, and automatically adjusts the delta threshold to that number of flags.

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05-09-2013 дата публикации

Method for collecting droplet attached on external surface of needle into capillary tube

Номер: US20130228224A1
Принадлежит: Panasonic Corp

In order to provide a method for collecting a droplet attached on an external surface of a needle into a capillary tube, the present invention is a method for collecting a droplet attached on an external surface of a needle into a capillary tube, the method comprising steps of (a) preparing a substrate comprising a capillary tube; a flexible thin film; a liquid-repellent film; and a hole; (b) moving the needle in the Z-direction to move the droplet from the external surface of the needle to the surface of the liquid-repellent film; (c) allowing the droplet to arrive at an inlet of the capillary tube by moving the needle more in the Z-direction, so as to suck the droplet into the capillary tube by a capillary phenomenon.

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12-09-2013 дата публикации

Delivery system for analytical samples

Номер: US20130236276A1
Автор: Daniel T. Richter
Принадлежит: Individual

A system for handling sample vials includes a vault for receiving a series of storage cartridges. Inside the cartridges are one or more discs providing vial recesses. In multidisc cartridges, through passages are provided to place and retrieve vials into and from the subjacent discs. A pick up device is moved until it aligns with a selected vial and the vial is pneumatically removed. A device is provided to reverse orientation of a vial moving through the system. A venturi operated system is provided including symmetrical bleed off ports to propel vials through the system without inducing excessive spinning of the vials. A piping system from a central bank to a multiplicity of analytical instruments includes a minimum number of through conduits and a diverter at each instrument location for sending the vial either to the instrument or downstream toward another diverter and instrument.

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