05-01-2017 дата публикации
Номер: US20170003300A1
Принадлежит:
Disclosed are methods of identifying, predicting and treating subjects at risk for exacerbation or the presence of a respiratory disease, by detecting expression levels of one or more proteins associated with the respiratory disease, wherein said one or more proteins is selected from the group of CCL24, IL2RA, APOA4, GC, IgA, LPA, KLK3 F, FAS, NRCAM, TNFRSFIOC, IL12B, IL23A, RAGE, CCL20, ICAM1, SERPINA7, CDH13 and CDH1, and wherein said respiratory disease may be chronic obstructive pulmonary disease or emphysema. 1. A method of identifying a subject at risk of exacerbation of a respiratory disease comprising:a. obtaining a biological sample from the subject;b. determining the expression level of at least one protein associated with the respiratory disease in the biological sample from the subject, wherein the protein is selected from the group consisting of CCL24, IL2RA, APOA4, GC, IgA, LPA, KLK3_F, FAS, NRCAM, TNFRSF10C, IL12B, IL23A and combinations thereof; andc. identifying the subject as at risk of exacerbation when the expression level of the at least one protein is altered as compared to the expression of level of the least one protein from a control.2. The method of claim 1 , wherein determining the expression level of at least one protein associated with the respiratory disease comprises comparing the expression level of the at least one protein associated with the respiratory disease from the subject with the expression level of the at least one protein from a control claim 1 , wherein the expression level of the least one protein is considered altered if the expression level of the least one protein as compared to the expression level from the control is increased or decreased.3. (canceled)4. (canceled)5. The method of claim 1 , wherein the at least one protein comprises a protein selected from the group consisting of CCL24 claim 1 , IL2RA claim 1 , APOA4 claim 1 , GC claim 1 , IgA claim 1 , LPA claim 1 , KLK3_F and combinations thereof.6. The method of ...
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