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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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Форма поиска

Поддерживает ввод нескольких поисковых фраз (по одной на строку). При поиске обеспечивает поддержку морфологии русского и английского языка
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Применить Всего найдено 941. Отображено 100.
05-07-2012 дата публикации

Integrated chemical sensor

Номер: US20120168882A1
Автор: Olivier Le Neel, Suman Cherian
Принадлежит: STMICROELECTRONICS PTE LTD

A integrated circuit die includes a chemical sensor, a thermal sensor, and a humidity sensor formed therein. The chemical sensor, thermal sensor, and humidity sensor include electrodes formed in a passivation layer of the integrated circuit die. The integrated circuit die further includes transistors formed in a monocrystalline semiconductor layer.

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Номер записи: 1
05-07-2012 дата публикации

Single chip having the chemical sensor and electronics on the same die

Номер: US20120171713A1
Автор: Olivier Le Neel, Suman Cherian
Принадлежит: STMICROELECTRONICS PTE LTD

A semiconductor die includes a chemical sensor, a digital to analog converter, and microcontroller formed therein. The chemical sensor detects the presence of a chemical and outputs an analog signal to the digital to analog converter. The analog to digital converter converts the analog signal to a digital signal. The analog to digital converter outputs the digital signal to the microcontroller. Microcontroller calculates a value of the concentration of the selected chemical.

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Номер записи: 2
02-05-2013 дата публикации

Rfid-based devices and methods for initializing a sensor

Номер: US20130106396A1
Автор: Ian James Forster
Принадлежит: Avery Dennison Corp

An RFID-based analyte sensor is provided with an antenna adapted to receive energy from an RF field and produce a signal. A sensing material is electrically connected to the antenna and has an electrical property which varies in the presence of an analyte. An energy storage device is also electrically connected to the antenna and is adapted to receive and store energy from the antenna and selectively discharge the stored energy. An initializing element is electrically connected to the energy storage device and is energized by the stored energy discharged by the energy storage device. When the initializing element is energized, it operates to reduce the analyte content of at least a portion of the sensing material, effectively initializing the sensing material.

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Номер записи: 3
27-06-2013 дата публикации

Reader Devices for Optical and Electrochemical Test Devices

Номер: US20130162981A1
Автор: Graham Davis, PIERRE Emeric, Sergey Gershtein, Thomas Ewart
Принадлежит: ABBOTT POINT OF CARE INC

This invention relates generally to devices and methods for performing optical and electrochemical assays and, more particularly, to devices having optical and electrochemical detectors and to methods of performing optical and electrochemical assays using such devices. The present invention is particularly useful for performing immunoassays and/or electrochemical assays at the point-of-care.

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Номер записи: 4
25-07-2013 дата публикации

Method and apparatus for lighted test strip

Номер: US20130190579A1
Автор: Abner D. Joseph, Brian A. Heald
Принадлежит: Roche Diagnostics Operations Inc

A test strip with a sample chamber is secured to a meter. The sample chamber in the portion of the test strip that extends out of the meter is illuminated by transmitting light from a light source inside the meter internally through the test strip towards the sample chamber. By way of analogy, the test strip acts in a fashion similar to a fiber optic cable or optical wave guide by transmitting the light from the meter to the remotely located sample chamber that extends outside the meter. The user is then able to easily see the sample chamber of the test strip in dark conditions so that the user is able to readily align the sample chamber with the drop of fluid on the skin as well as view the sample chamber in order to ensure proper filling. The light also illuminates a test strip slot into which the test strip is inserted.

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Номер записи: 5
27-03-2014 дата публикации

System and apparatus for determining temperatures in a fluid analyte system

Номер: US20140083848A1
Автор: Andrew J. Edelbrock, Jeffery S. Reynolds, John P. Creaven, Matthew B. Holzer, Mu Wu, Narasinha C. Parasnis, Paul M. Ripley, Steve Hoi-Cheong Sun, Steven C. Charlton, Swetha Chinnayelka, XIN Wang
Принадлежит: Bayer HealthCare LLC

A test sensor includes a body, a first conductive trace, a second conductive trace, and a third conductive trace. The body includes a first region that has a fluid-receiving area, a second region separate from the first region, and a first temperature sensing interface disposed at or adjacent to the fluid-receiving area. The fluid-receiving area receives a sample. The first trace is disposed on the body, and at least a portion of the first trace is disposed in the first region. The second and third traces are disposed on the body. The third trace extends from the first to the second regions. The third trace is connected to the first trace at the first temperature sensing interface. The third trace includes a different material than the first trace. A first thermocouple is formed at the first temperature sensing interface. The thermocouple provides temperature data to determine an analyte concentration.

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Номер записи: 6
05-01-2017 дата публикации

SYSTEM FOR ANALYZING A LIQUID SAMPLE

Номер: US20170003202A1
Автор: Laurens Paul, POHER Vincent, Pouteau Patrick
Принадлежит:

The invention relates to a system for analyzing a liquid sample, including an analysis device comprising a casing including a through-opening leading into a housing adapted to receive a portion of a collecting device and extending longitudinally from the opening along an axis of insertion of the collecting device. The analysis system further includes a collecting device comprising a main body extending along a longitudinal axis and including a fluid chamber adapted to be inserted in the housing along the insertion axis and a receiving surface intended to receive the liquid sample extending substantially orthogonally relative to the axis of the main body. 118-. (canceled)20. The system according to claim 19 , wherein the housing of the analysis device and the collecting device are both sized so that claim 19 , when the main body of the collecting device is inserted in the housing claim 19 , the distance between the collecting orifice and the measuring chamber is approximately equal to the distance between the opening of the housing and the measuring chamber claim 19 , and is preferably less than or equal to 2 cm.21. The system according to claim 19 , wherein the collecting device includes a collecting portion assembled to the main body and one surface of which forms the receiving surface claim 19 , this collecting portion being in contact with a wall of the casing at the edge of the opening of the housing when the main body of the collecting device is inserted in the housing.22. The system according to claim 19 , wherein the casing includes an upper wall and a lower wall connected to each other by a lateral wall having dimensions less than the dimensions of the upper and lower walls claim 19 , the opening of the housing is situated at the level of the upper wall of the casing and the housing extends substantially orthogonally to the latter in the direction of the lower wall.23. The system according to claim 22 , wherein the upper wall of the casing comprises a ...

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Номер записи: 7
10-01-2019 дата публикации

Measuring Apparatus, Computer Readable Medium Storing Measuring Program and Measuring Method

Номер: US20190011467A1
Автор: Shimizu Takeshi
Принадлежит: ARKRAY, INC.

A measuring apparatus includes: a measuring unit to measure a signal value corresponding to a concentration of a specified substance of a first sample; an acquiring unit to acquire a reference value pertaining to the specified substance of a second sample; a calculating unit to calculate a concentration value of the specified substance of the first sample, based on the signal value and the reference value; a timing determination unit to determine timing for calibrating the reference value when satisfying at least one of a first condition that an activity status of a user is a predetermined status and a second condition that a variation in the concentration value of the specified substance of the first sample is equal to or smaller than a threshold value; and an input request unit to request the user to input the reference value at the determined timing. 1. A measuring apparatus comprising:a status determining unit configured to determine an activity status of a user from a signal outputted by at least one activity sensor configured to detect an activity factor of the user;a measuring unit configured to measure a signal value corresponding to a concentration of a specified substance contained in a first sample;an acquiring unit configured to acquire a reference value pertaining to the specified substance contained in a second sample;a calculating unit configured to calculate a concentration value of the specified substance contained in the first sample, based on the signal value and the reference value;a timing determination unit configured to determine timing for calibrating the reference value when satisfying at least one of a first condition that the activity status of the user is a predetermined status and a second condition that a variation in the concentration value of the specified substance contained in the first sample is equal to or smaller than a threshold value; andan input request unit configured to request the user to input the reference value at the ...

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Номер записи: 8
18-01-2018 дата публикации

Diagnostic device

Номер: US20180015457A1
Автор: Chantelle Domingue, Jeremy Sells, Manish Giri, Nicholas McGuinness
Принадлежит: Hewlett Packard Development Co LP

A microfluidic diagnostic device may comprise a fluid inlet to receive a fluid from a fluidic slot, a main microfluidic channel fluidly coupled to the fluid inlet, and a main microfluidic pump interposed between the fluid inlet and the main microfluidic channel to continuously circulate a fluid through the fluidic slot, fluid inlet, and main microfluidic channel wherein the width of the fluid inlet is different from the width of the main microfluidic channel. A diagnostic device, comprising a fluidic slot, a fluid inlet fluidly coupled to the fluidic slot, a main channel fluidly coupled to the fluid inlet, and an inlet pump interposed between the fluid inlet and channel wherein the cross-sectional area of the fluid inlet is relatively larger at least one point than the cross-sectional area of the channel.

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Номер записи: 9
18-01-2018 дата публикации

Charging device for biological information measurement device and biological information measurement device charged using same

Номер: US20180017544A1
Автор: Tatsuhiko Furukawa
Принадлежит: Panasonic Healthcare Holdings Co Ltd

Certain implementations have a main body case having a contact face of a biological information measurement device on its surface, and a first non-contact charging portion composed of a charging coil disposed opposite the contact face with the biological information measurement device inside the main body case. In addition, some may have a controller that is connected to the first non-contact charging portion, and a display section that is connected to the controller. Upon completion of the charging of the biological information measurement device via the first non-contact charging portion, the controller connected to the display section may display on the display section that the biological information measurement device will be incapable of measurement for a specific length of time.

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Номер записи: 10
21-01-2021 дата публикации

METHOD AND SYSTEM FOR DETECTING AN ANALYTE PRESENT IN A LIQUID SPECIMEN

Номер: US20210018488A1
Автор: BORDY Thomas, Cubizolles Myriam-Laure, Revol-Cavalier Frederic
Принадлежит: Commissariat a I'Energie Atomique et aux Energies Alternatives

The invention relates to a method for detecting an analyte present in a liquid specimen, characterized in that it comprises steps of: 1. Method for detecting an analyte present in a liquid specimen , characterized in that it comprises steps of:-positioning a medium including a detection chamber on a device for preparing by coring,preparing by coring a solid specimen and dissolving or re-suspending said specimen with a view to obtaining a liquid specimen,injecting said liquid specimen into said detection chamber, said detection chamber having a non-zero volume enclosing polymeric beads covered with a reagent suitable for said analyte to be detected, allowing an agglutination reaction in the presence of the analyte,capturing at least one image of at least one region of the detection chamber using a sensor,processing said image acquired by the sensor, this comprising determining a texture level of said acquired image, said texture level depending on the agglutination level of the polymeric beads in the presence of the analyte, and determining a concentration of said analyte depending on the texture level determined for said image.2. Method according to claim 1 , characterized in that the capturing step is carried out by defocused imaging.3. System for detecting an analyte present in a liquid specimen claim 1 , comprising:a medium equipped with a fluidic circuit, said fluidic circuit comprising at least one injection channel and a detection chamber into which said injection channel opens, said detection chamber having a non-zero volume enclosing polymeric beads covered with a reagent suitable for said analyte to be detected,a device for preparing the liquid specimen to be analysed, on which is fitted said medium, said preparing device comprising an implement for coring a sample of material and an implement for dissolving or re-suspending each core produced by said coring implement, to which is connected said injection channel of the fluidic circuit, an optical read-out ...

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Номер записи: 11
25-01-2018 дата публикации

SENSOR HEAD FOR USE WITH IMPLANTABLE DEVICES

Номер: US20180024086A1
Автор: Brauker James H., Rhodes Rathbun K., Shults Mark C., Tapsak Mark A.
Принадлежит:

The present invention provides a sensor head for use in an implantable device that measures the concentration of an analyte in a biological fluid which includes: a non-conductive body; a working electrode, a reference electrode and a counter electrode, wherein the electrodes pass through the non-conductive body forming an electrochemically reactive surface at one location on the body and forming an electronic connection at another location on the body, further wherein the electrochemically reactive surface of the counter electrode is greater than the surface area of the working electrode; and a multi-region membrane affixed to the nonconductive body and covering the working electrode, reference electrode and counter electrode. In addition, the present invention provides an implantable device including at least one of the sensor heads of the invention and methods of monitoring glucose levels in a host utilizing the implantable device of the invention. 1. A sensor for use in a glucose measuring device , the sensor comprising:a first electrode, a second electrode, and a non-conductive body located between the first electrode and the second electrode, wherein the first electrode and the second electrode each form an electrochemically reactive surface at one end of the sensor and an electronic connection at another end of the sensor; anda multi-region membrane covering the first electrode and the second electrode, wherein the multi-region membrane comprises an immobilized enzyme domain comprising an enzyme in at least a portion thereof, wherein the multi-region membrane comprises a glucose exclusion domain that is permeable to oxygen and interferes with glucose transport across said membrane, and wherein said glucose exclusion domain does not cover the working electrode.2. The sensor of claim 1 , wherein the multi-region membrane further comprises an interference domain more proximal to said electrochemically reactive surfaces than said glucose exclusion domain.3. The ...

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Номер записи: 12
25-01-2018 дата публикации

Meter with Changeable Modules

Номер: US20180024107A1
Автор: Modzelewski Brent E., Rounds George R.
Принадлежит:

A customizable diagnostic meter is provided. The diagnostic meter includes a meter for performing a diagnostic test, wherein the meter includes a housing having a slot, and a module having one or more functions. The slot is configured to receive and removably secure at least a portion of the module. A customizable diagnostic meter kit including two or more modules configured to be inserted in a meter is also provided. 1. A customizable diagnostic meter comprising:a meter for performing a diagnostic test of an analyte in a sample applied to a test strip, the meter comprising a housing having at least one slot and a test strip port configured to receive the test strip; anda module having one or more functions relating to the diagnostic test of the analyte; anda module extender connected to the module and configured to act as an adapter to removably couple one or more additional modules to the meter, the additional modules having one or more functions relating to the diagnostic test of the analyte, andwherein the at least one slot is configured to receive and removably secure at least a portion of a module.2. The meter of claim 1 , wherein the meter is a blood glucose meter.3. The meter of claim 1 , wherein the meter is portable.4. The meter of claim 1 , wherein the module is a passive module.5. The meter of claim 1 , wherein the module is an active module.6. The meter of claim 1 , wherein the module is a portable vial claim 1 , a lancing device claim 1 , a USB module claim 1 , a wireless connection module claim 1 , an audio module claim 1 , a backlight module claim 1 , a flashlight claim 1 , a carbohydrate counter claim 1 , an insulin bolus calculator claim 1 , or a scanner claim 1 , or a combination thereof.7. The meter of wherein the meter or the module comprise a wireless connection.8. The meter of claim 1 , wherein the module is a multi-function module.9. The meter of claim 8 , wherein the multi-function module includes a carbohydrate counter and a scanner.10. The ...

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Номер записи: 13
24-01-2019 дата публикации

Calibration material delivery devices and methods

Номер: US20190025318A1
Автор: Christopher L. Stewart, Jennifer Y. Blomo, John F. Larkin, Kelley J. Lipman, Kimberly J. Tansey, Michael F. Tomasco, Paul D. Reynolds, Peter Uy-Vu Ly, Raul Escutia, Robert W. Bowers, Robin S. Gaffney
Принадлежит: Intuity Medical Inc

A device includes: a first portion configured to be grasped by the hand of the user, and a second portion defining a reservoir containing a control material, wherein the control material contains a target analyte in a known or predetermined concentration. A method of verifying the accuracy of an analyte monitoring device includes receiving control information, receiving a fluid sample, identifying the fluid sample as a control solution, and analyzing the control solution.

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Номер записи: 14
28-01-2021 дата публикации

LATERAL FLOW ASSAY READER BASED ON HUMAN PERCEPTION AND METHOD RELATING THERETO

Номер: US20210025828A1
Автор: Farrell Robert P.
Принадлежит:

An instrument for reading a lateral flow assay device by detecting color changes based on human perception includes an optics module having a camera, a signal processor, a storage memory and a comparator circuit. The storage memory has stored therein a dataset of sample readings of reference assay devices similar in structure and function to that of the lateral flow assay device. The sample readings are based on human visual perceptions of colorimetric changes in the detection zones of the reference assay devices. The comparator circuit compares the measured colorimetric data relating to the assay device read by the instrument with the stored database of sample readings based on human visual perceptions of the colorimetric changes of the reference assay devices, and generates a comparison signal which is provided to the signal processor. The signal processor generates a determination signal indicative of the presence, absence or quantity of an analyte. 1. An instrument for reading a lateral flow assay device placed in optical proximity thereto for performing an assay to determine the presence , absence or quantity of an analyte in a fluid sample , the assay device having a sample deposit zone on which a fluid sample to be tested is placed and further having a detection zone in which a visually perceptible colorimetric change may occur when the assay device detects the presence , absence or quantity of an analyte in the fluid sample , the instrument comprising:an optics module, the optics module having at least one light source and a light detector, the at least one light source emitting light and being positioned on the instrument to direct the light onto the detection zone of the assay device placed in optical proximity to the instrument, the light detector receiving reflected or fluoresced light emanating from the detection zone of the assay device in response to the light directed thereon by the at least one light source, and generating an output signal in ...

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Номер записи: 15
28-01-2021 дата публикации

SYSTEM FOR MEASURING CHARGES PROPAGATING THROUGH A BIOLOGICAL OBJECT

Номер: US20210025867A1
Автор: Richter Wolfgang, Zadeh Faranak
Принадлежит:

Disclosed is a system for measuring electrical charges propagating through a biological object. The system includes an implantable medical device inserted into the biological object, an electronic implant attached to the implantable medical device for measuring, processing and communicating electrical charges, at least one transponder configured on the implantable medical device to convert mechanical waves into electrical charges, wherein the electrical charges propagate through the biological object to be received by the electronic implant; and an external electronic hub device for providing electrical charges to influence the biological object. The external electronic hub device includes a controller, a frequency generator, a resonator, a filter unit, and an electrode. The electronic implant includes an arrangement of sub-circuits, an energy convertor, an amplifier, an analog/digital converting logic circuit, and a modulator. The amplifier receives the amplified bio-electrical charges while suppressing electrical influence, further the amplifier creates an amplified analog value representing the bio-electrical charges. 1. A system for measuring charges propagating through a biological object , the system comprising:an implantable medical device inserted into the biological object;an electronic implant attached to the implantable medical device for measuring, processing and communicating electrical charges;at least one transponder configured on the implantable medical device to convert mechanical waves into electrical charges, wherein the electrical charges propagate through the biological object to be received by the electronic implant; and a controller contactlessly power and communicates data with the electronic implant;', 'a frequency generator for generating alternating charges;', 'a resonator for resonating and reflecting data modulation;', 'a filter unit for mixing data received from the controller with the alternating charges and further the filter unit ...

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Номер записи: 16
02-02-2017 дата публикации

Spatial Orientation Determination In Portable Clinical Analysis Systems

Номер: US20170030888A1
Автор: Davis Graham, Emeric Pierre, Soman Narendra, Vandersleen Gary, Wasserman Paul
Принадлежит:

The present invention covers the integration and utility of accelerometer features into a clinical analysis system. For example, measurement of dynamic acceleration and orientation of a blood-testing instrument with respect to Earth's gravitational field may be used to determine reliability of a test procedure and optionally to provide corrective elements thereof. 1. A method of performing an analytical test , the method comprising:initiating, by an analyzer, a test cycle of a test device;determining spatial orientation of the analyzer during the test cycle of the test device;comparing the determined spatial orientation to a threshold operating spatial plane for the test device; andproviding an alert that at least one of instructs and illustrates corrective action including required movement of the analyzer to bring the spatial orientation of the analyzer within the threshold operating spatial plane for the test device in order to prompt a user to take the corrective action for the test device during the test cycle, when the determined spatial orientation exceeds the threshold operating spatial plane.2. The method of claim 1 , further comprising receiving the corrective action for the test device prior to the test cycle ending with a determination of a result of the analytical test.3. The method of claim 2 , further comprising correcting the result of the analytical test claim 2 , when the determined spatial orientation exceeds the threshold operating spatial plane.4. The method of claim 1 , further comprising detecting at least one target analyte selected from the group consisting of: hematocrit claim 1 , troponin claim 1 , creatine kinase myocardial band (CKMB) claim 1 , brain natriuretic peptide (BNP) claim 1 , beta human chorionic gonadotropin (bHCG) claim 1 , carbon dioxide partial pressure (pCO) claim 1 , partial pressure oxygen (pO) claim 1 , pH claim 1 , prothrombin time (PT) claim 1 , activated clotting time (ACT) claim 1 , activated partial thromboplastin ...

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Номер записи: 17
05-02-2015 дата публикации

Charging device for biological information measurement device and biological information measurement device charged using same

Номер: US20150033880A1
Автор: Tatsuhiko Furukawa
Принадлежит: Panasonic Healthcare Co Ltd

The present invention has a main body case having a contact face of a biological information measurement device on its surface, and a first non-contact charging portion ( 7 ) composed of a charging coil disposed opposite the contact face with the biological information measurement device inside the main body case. In addition, it has a controller ( 8 ) that is connected to the first non-contact charging portion ( 7 ), and a display section ( 5 ) that is connected to the controller ( 8 ). Upon completion of the charging of the biological information measurement device via the first non-contact charging portion ( 7 ), the controller ( 8 ) connected to the display section ( 5 ) displays on the display section ( 5 ) that the biological information measurement device will be incapable of measurement for a specific length of time.

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Номер записи: 18
30-01-2020 дата публикации

MEDICAL DEVICE FOR STIMULATING AND SENSING BIOACTIVITY

Номер: US20200033322A1
Автор: Deligianni Harikilia, Doris Bruce B., Holmes Steven J., Kinser Emily R., Lin Qinghuang
Принадлежит:

In an approach, a biomedical device comprises at least one electrode, wherein the at least one electrode is coupled with a computer chip; at least two chemical sensors, wherein the at least two chemical sensors are coupled with the computer chip; the computer chip, wherein the computer chip comprises: a semiconductor substrate, and a processor; a microfluidic structure, wherein the microfluidic structure is an inert elastomeric polymer; a power supply device coupled to the computer chip; and an antenna configured to send data collected onto the computer chip to a remote server. In an approach, a processor stimulating a cell sample. A processor senses the presence of at least two types of biomolecules released by the cell sample. A processor records data collected by the at least two chemical sensors. A processor sends the recorded data to a remote server. 1. An apparatus for a biomedical device , the apparatus comprising:at least one electrode, wherein the at least one electrode is coupled with a computer chip;at least two chemical sensors, wherein the at least two chemical sensors are coupled with the computer chip; a semiconductor substrate, and', 'a processor;, 'the computer chip, wherein the computer chip comprisesa microfluidic structure, wherein the microfluidic structure is an inert elastomeric polymer;a power supply device coupled to the computer chip; andan antenna configured to send data collected onto the computer chip to a remote server.2. The apparatus of claim 1 , wherein the at least one electrode is configured to stimulate a cell sample.3. The apparatus of claim 1 , wherein the at least one electrode is configured to sense a voltage differential across a cell sample.4. The apparatus of claim 1 , wherein the at least one electrode is configured to stimulate a cell sample and sense a voltage differential across the cell sample.5. The apparatus of claim 1 , wherein a first chemical sensor of the at least two chemical sensors is an amperometric sensor ...

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Номер записи: 19
30-01-2020 дата публикации

INFORMATION PROCESSING DEVICE, INFORMATION PROCESSING METHOD, AND CELL ANALYZING SYSTEM

Номер: US20200033324A1
Автор: Abe Tomoteru
Принадлежит: SONY CORPORATION

The present technology provides a technology capable of analyzing efficacy of a drug in a subject before administration or at an early stage after administration in cancer immunotherapy with an immune checkpoint inhibitor. 1. An information processing device at least comprising:an analyzing unit which analyzes a result of measurement over time of oxygen consumption rates of different types of immune cells collected from a subject stored for each cell in sealable micro-wells and/or a change in pH around the immune cell; andan output unit which outputs a prediction result of efficacy of an anticancer drug in the subject on a basis of a result of the analysis.2. The information processing device according to claim 1 , wherein the measured result is a result measured when the immune cell is stressed by drug stimulation and/or a change in external environment.3. The information processing device according to claim 1 , wherein the measured result is a result measured by using an oxygen sensor and/or a pH sensor immobilized in at least a part of the micro-well.4. The information processing device according to claim 3 ,wherein the micro-well is formed by using a translucent material, andthe measured result is a result of measurement over time of a change of the oxygen sensor and/or a change of the pH sensor by using an optical means with respect to the micro-well.5. The information processing device according to claim 4 , wherein the analyzing unit further analyzes a decay time of phosphorescence or fluorescence obtained from the oxygen sensor and/or the pH sensor.6. The information processing device according to claim 1 , wherein the analyzing unit further performs profiling of energy metabolism of each immune cell on a basis of the measured result.7. The information processing device according to claim 6 , wherein the profiling is performed by analyzing a subtype of the immune cell determined from analysis of a surface antigen of the immune cell and a combination of ...

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Номер записи: 20
08-02-2018 дата публикации

SCALABLE AND HIGH THROUGHPUT BIOSENSING PLATFORM

Номер: US20180038843A1
Автор: Kuan Germano José António Henriques, Piedade Moisés Simões
Принадлежит:

A multi-channel high performance embedded system is provided, which is capable of high throughput biological analysis. A configurable acquisition and processing architecture combines dedicated co-processors to perform signal filtering and other computational demanding tasks, with a central processor controlling the whole system. The mapping of the architecture into an architecture, such as the Zynq SoC, demonstrates the ability of the biosensing platform to support a significant number of sensors, while ensuring a high sampling frequency. Furthermore, the Zynq reconfiguration abilities provide a mechanism to adapt the processing and maximize the biological sensitivity. 1. A biological detection system comprising:an integrated biochip having at least two blocks of sensors, each block of sensors having a signal acquisition channel that is independently accessible such that each block of sensors can be read in parallel; and drive circuitry to drive each block of sensors of the biochip;', 'a set of acquisition interfaces arranged such that a select one acquisition interface is coupled to a corresponding one signal acquisition channel;', 'a set of co-processors such that a select co-processor is uniquely associated with a corresponding one of the acquisition interfaces; and', 'a central processor that controls the drive circuitry, interfaces with the set of acquisition interfaces and interfaces with the set of co-processors, to read data from the biochip., 'a biosensing platform having216. The biological detection system of claim 1 , wherein said each block of sensors having an array of at least sensors and a corresponding time division multiplexer to read out individual sensors from a corresponding block.3. The biological detection system of claim 1 , wherein the set of acquisition interfaces further comprises an analog to digital converter and a controller claim 1 , where the controller conveys information from the analog to digital converter to its corresponding co- ...

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Номер записи: 21
16-02-2017 дата публикации

Analyte Sensor Calibration Management

Номер: US20170042456A1
Автор: Budiman Erwin Satrya
Принадлежит: ABBOTT DIABETES CARE INC.

Methods, devices, and systems for calibrating an analyte sensor are provided. Embodiments include determining a sensitivity value associated with an analyte sensor, retrieving a prior sensitivity value associated with the analyte sensor, determining whether a variance between the determined sensitivity value and the retrieved prior sensitivity value is within a predetermined sensitivity range, determining a composite sensitivity value based on the determined sensitivity value and the retrieved prior sensitivity value, and assigning a successful calibration sensitivity value based on the retrieved prior sensitivity value when the variance is within the predetermined sensitivity range. 1determining, using one or more processors, whether a first variance between a first sensitivity value and a second sensitivity value is within a first predetermined range;retrieving a first composite sensitivity value when it is determined that the first variance is not within the first predetermined range, wherein the retrieved first composite sensitivity value includes two or more prior time spaced sensitivity values;determining, using the one or more processors, whether a second variance between the first sensitivity value and the retrieved first composite sensitivity value is within a second predetermined range; andassigning a calibration sensitivity value based on the retrieved first composite sensitivity value when the second variance is within the second predetermined range.. A method, comprising: The present application is a continuation of U.S. patent application Ser. No. 14/077,004 filed Nov. 11, 2013, which is a continuation-in-part of U.S. patent application Ser. No. 12/762,288 filed Apr. 16, 2010, now U.S. Pat. No. 8,583,205, which is a continuation-in-part of U.S. patent application Ser. No. 12/363,712 filed Jan. 30, 2009, now U.S. Pat. No. 8,346,335, which claims priority to U.S. Provisional Application No. 61/040,633 filed Mar. 28, 2008 and U.S. patent application Ser. ...

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Номер записи: 22
16-02-2017 дата публикации

Analyte Measurement Devices and Systems, and Components and Methods Related Thereto

Номер: US20170045468A1
Автор: Bulala Cherie, Myles Christopher, Simmons Matthew, Song Bonita Park
Принадлежит:

In some aspects, a modular analyte measurement system having a replaceable strip port module is provided to permit contaminated modules to be replaced. Some aspects of the present disclosure related to barriers for strip ports or the sealing of strip ports and/or analyte measurement devices to maintain a clean strip port and/or enable the strip port to be cleaned for reuse. Cleaning tools are also provided. Also provided are strip port interfaces that guide fluid away from the strip port opening, as well as absorptive elements that prevent fluid from entering a strip port. Analyte measurement devices with gravity sensors or accelerometers are also provided, along with methods related thereto. Also provided are docking station that serve as an information server and provides storage and recharging capabilities. 118-. (canceled)19. A method for determining the concentration of analyte in a sample using an analyte measurement system , the method comprising: a module housing comprising an electrical interface aperture that exposes an electrical interface within the module housing, and', 'an analyte test strip port disposed within the module housing and comprising electrical contacts that couple to an analyte test strip positioned in the analyte test strip port,', 'wherein the electrical interface is disposed within the module housing and coupled to the analyte test strip port, and wherein the electrical interface comprises a plurality of electrical contacts that couple to electrical contacts of the analyte meter through the electrical interface aperture of the module housing;, 'positioning a replaceable strip port module within a strip port cavity of a housing of an analyte meter, wherein the analyte meter comprises the housing and electrical connections disposed with the strip port cavity within the housing, and the replaceable strip port module comprisescontacting the sample to the analyte test strip positioned in the analyte test strip port of the replaceable strip ...

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Номер записи: 23
13-02-2020 дата публикации

SYSTEM AND APPARATUS FOR DETERMINING AMBIENT TEMPERATURES FOR A FLUID ANALYTE SYSTEM

Номер: US20200049568A1
Автор: Wu Mu
Принадлежит:

A system and method for rapidly determining ambient temperature in a fluid-analyte meter. The meter includes a housing defining an interior space and an area for receiving a fluid sample. A processor and a first temperature sensor are disposed within the interior space of said the housing. A second temperature sensor is disposed on the housing. One or more processors are configured to determine a first temperature value from temperature data received from the first temperature sensor. The processor(s) are also configured to apply a variable current to a temperature-adjustment source such that the second temperature sensor is adjusted to a predetermined steady-state temperature value different from the first temperature value. The processor(s) are further configured to determine an ambient temperature of an exterior space of the housing based on the applied variable current, pre-determined steady-state temperature, and received first temperature values. 126-. (canceled)27. A portable instrument for determining a blood glucose concentration of a blood sample , the portable instrument including systems for rapidly determining an ambient temperature , the portable instrument comprising:a protective casing defining an interior space, an area for receiving a blood sample, and an exterior ambient environment;a physical processor and a first temperature sensor disposed within the interior space; anda second temperature sensor disposed at least partially within the protective casing; and determine a first temperature value from temperature data received from the first temperature sensor,', 'apply a variable current to a temperature-adjustment source such that the second temperature sensor is adjusted to a predetermined steady-state temperature value different from the first temperature value, and', 'determine an ambient temperature of the exterior ambient environment, the ambient temperature based on the applied variable current, the pre-determined steady-state temperature ...

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Номер записи: 24
03-03-2016 дата публикации

Displays for a Medical Device

Номер: US20160058345A1
Автор: Annie C. Tan, Gary Alan Hayter, Glenn Howard Berman, Kenneth J. Doniger, Mark Kent Sloan, Michael Love, Phillip Yee, R. Curtis Jennewine, Timothy Christian Dunn, Wesley Scott Harper
Принадлежит: Abbott Diabetes Care Inc

Embodiments described herein relate to an analyte monitoring device having a user interface with a display and a plurality of actuators. The display is configured to render a plurality of display screens, including a home screen and an alert screen. The home screen is divided into a plurality of simultaneously displayed panels, with a first panel displays a rate of change of continuously monitored analyte levels in interstitial fluid, a second panel simultaneously displays a current analyte level and an analyte trend indicator, and a third panel displays status information of a plurality of components of the device. When an alarm condition is detected, the display renders the alert screen in place of the home screen, the alert screen displaying information corresponding to the detected alarm condition. Furthermore, the actuators are configured to affect further output of the analyte monitoring device corresponding to the detected condition.

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Номер записи: 25
01-03-2018 дата публикации

SENSOR ASSEMBLY, TEST SUBSTANCE MONITORING SYSTEM, AND TEST SUBSTANCE MONITORING METHOD

Номер: US20180055424A1
Автор: HORI Nobuyasu, Kojima Junko, SUMINAKA Chihiro
Принадлежит:

Disclosed are a novel means capable of accurately calculating the amount of in-vivo components as a test substance, and its uses. A sensor assembly includes an electrochemical sensor for measuring a test substance percutaneously extracted from a living body, and a processor for calculating the intensity of the background signal at the measurement time point of the test substance after the elapse of the predetermined time based on the change over time of the intensity of the background signal measured within a predetermined time before measurement of the test substance by the electrochemical sensor . In this way, the amount of the in-vivo component as the test substance can be accurately calculated since the calculated value of the intensity of the background signal to be subtracted from the unprocessed signal including the signal attributable to the test substance can be obtained. 1. A sensor assembly comprising:an electrochemical sensor for measuring a test substance percutaneously extracted from a living body; anda processor programmed to determine the intensity of the background signal at a measurement time point of the test substance outside the predetermined time based on the intensity of the background signal measured within the predetermined time by the electrochemical sensor.2. The sensor assembly according to claim 1 , whereinthe predetermined time is the time period from when the electrochemical sensor is energized to when the measured value by the electrochemical sensor stabilizes.3. The sensor assembly according to claim 1 , whereinthe electrochemical sensor is configured to measure a test substance extracted into a collection member from the living body in a state in which the test substance is in contact with the collecting member;the predetermined time is the time before the test substance is extracted to the collection member after the electrochemical sensor is brought into contact with the collecting member; andthe electrochemical sensor measures ...

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Номер записи: 26
21-02-2019 дата публикации

Devices, systems, and methods for performing optical assays

Номер: US20190056329A1
Автор: Barry Bass, Michael Louie Low, Sergey Gershtein
Принадлежит: ABBOTT POINT OF CARE INC

This present invention relates generally to devices, systems, and methods for performing optical and electrochemical assays and, more particularly, to devices and systems having universal channel circuitry configured to perform optical and electrochemical assays, and methods of performing the optical and electrochemical assays using the universal channel circuitry. The universal channel circuitry is circuitry that has electronic switching capabilities such that any contact pin, and thus any sensor contact pad in a testing device, can be connected to one or more channels capable of taking on one or more measurement modes or configurations (e.g., an amperometric measurement mode or a current drive mode).

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Номер записи: 27
03-03-2016 дата публикации

ANALYTE SENSORS AND SYSTEMS INCLUDING RETENTION TAB AND METHODS OF MANUFACTURING SAME

Номер: US20160061765A1
Автор: Charlton Steven C.
Принадлежит:

In some aspects, an analyte sensor is provided for detecting an analyte concentration level in a biological fluid sample. The analyte sensor has a base including a top and bottom side, a lid, and an attachment member including one or more retention tabs coupled proximate the top side so that the analyte sensor can be grasped by the sensor's top side. Manufacturing methods and systems adapted to use and dispense the analyte sensors are provided, as are numerous other aspects. 1. An analyte testing system , comprising:an analyte meter including a pylon having grasping tabs; andan analyte sensor including a base with a top side, a lid proximate the base on the top side, and an attachment member proximate the top side, the attachment member including one or more retention tabs engaging with the grasping tabs to secure the analyte sensor to the pylon.2. The analyte testing system of claim 1 , further comprising electrical connectors on the pylon adapted to contact electrical contact pads provided on a same side of the base as the attachment member.3. The analyte testing system of claim 1 , wherein the grasping tabs are movable to release the attachment member.4. The analyte testing system of claim 3 , comprising a user-operable mechanism adapted to initiate movement of the grasping tabs.5. An analyte sensor dispenser apparatus claim 3 , comprising:a dispenser body having a recess extending in the dispenser body and an opening; anda plurality of analyte sensors provided in a stacked configuration within the recess, the plurality of analyte sensors including an attachment member having one or more retention tabs disposed towards the opening and adapted to be grasped by an analyte meter.6. The analyte sensor dispenser system of claim 5 , wherein the attachment member includes two retention tabs. This application is a division of U.S. patent application Ser. No. 13/589,377, filed Aug. 20, 2012, titled “ANALYTE SENSORS AND SYSTEMS INCLUDING RETENTION TAB AND METHODS OF ...

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Номер записи: 28
01-03-2018 дата публикации

SENSOR ASSEMBLY

Номер: US20180059091A1
Автор: Lehmann Daniel, SCHIBLI Matthias
Принадлежит: SENSIRION AG

A sensor assembly comprises a substrate arrangement and a sensor chip mounted to the substrate arrangement. A sensing element is integrated on or in the sensor chip and is sensitive to at least one parameter of a fluid. An access opening is provided in the substrate arrangement enabling the fluid to access the sensing element. A metallization arranged on at least a portion of the substrate arrangement seals a chamber containing the sensor chip which portion comprises one or more of a wall defining the access opening or an area facing the sensor chip. 1. A sensor assembly , comprisinga substrate arrangement,a sensor chip mounted to the substrate arrangement,a sensing element integrated on or in the sensor chip and sensitive to at least one parameter of a fluid,an access opening in the substrate arrangement enabling the fluid to access the sensing element,a metallization arranged on at least a portion of the substrate arrangement which portion comprises one or more of a wall defining the access opening or an area facing the sensor chip.2. The sensor assembly of claim 1 ,wherein the substrate arrangement comprises a substrate,wherein the access opening comprises a through-hole in the substrate,wherein the sensor chip comprises a front side on or in which the sensing element is integrated,wherein the sensor chip is flip-chip mounted to the substrate with the front side facing the substrate, and in particular with the front side facing the through-hole.3. The sensor assembly of claim 2 ,wherein the metallization includes a coverage of the wall defining the through-hole in the substrate.4. The sensor assembly of claim 2 ,wherein the metallization includes a ring around the through-hole on an inner side of the substrate facing the sensor chip.5. The sensor assembly of claim 2 ,wherein the metallization includes a ring around the through-hole on an outer side of the substrate opposite the inner side.6. The sensor assembly of claim 2 ,wherein the through-hole is a plated ...

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Номер записи: 29
07-03-2019 дата публикации

Displays for a Medical Device

Номер: US20190069852A1
Автор: Annie C. Tan, Gary Alan Hayter, Glenn Howard Berman, Kenneth J. Doniger, Mark Kent Sloan, Michael Love, Phillip Yee, R. Curtis Jennewine, Timothy Christian Dunn, Wesley Scott Harper
Принадлежит: Abbott Diabetes Care Inc

Embodiments described herein relate to an analyte monitoring device having a user interface with a display and a plurality of actuators. The display is configured to render a plurality of display screens, including a home screen and an alert screen. The home screen is divided into a plurality of simultaneously displayed panels, with a first panel displays a rate of change of continuously monitored analyte levels in interstitial fluid, a second panel simultaneously displays a current analyte level and an analyte trend indicator, and a third panel displays status information of a plurality of components of the device. When an alarm condition is detected, the display renders the alert screen in place of the home screen, the alert screen displaying information corresponding to the detected alarm condition. Furthermore, the actuators are configured to affect further output of the analyte monitoring device corresponding to the detected condition.

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Номер записи: 30
17-03-2016 дата публикации

APPARATUS FOR DIAGNOSTIC METER STRIP CONTROL AND IDENTIFICATION

Номер: US20160077039A1
Автор: Combs Brad, Leone Steven V., Modzelewski Brent E.
Принадлежит:

A system for measuring a property of a sample in a liquid which includes a test strip and a meter is provided. Some embodiments relate to a diagnostic test strip for collecting a sample, the strip having a plurality of electrodes for measuring a property of the sample, and the strip having a control circuit at a distal region of the strip, the control circuit configured to communicate with a controller of a meter, the control circuit including an embedded temperature sensor, a memory for lot coding and authentication of the test strip, and an inhibit logic for inhibiting the test from being used more than once; and a diagnostic meter for receiving the test strip, the meter having a controller programmed to communicate with the control circuit. 1. A system for measuring a property of a sample in a liquid , comprising:a diagnostic test strip for collecting a sample, the strip having a plurality of electrodes for measuring a property of the sample, and the strip having a control circuit at a distal region of the strip, configured to communicate with a controller of a meter, the control circuit including an embedded temperature sensor, a memory for lot coding and authentication of the test strip, and an inhibit logic for inhibiting the test from being used more than once; anda diagnostic meter for receiving the test strip, the meter having a controller programmed to communicate with the control circuit.2. The system according to claim 1 , wherein the control circuit comprises a non-volatile string of bits used to identify the strip as authentic.3. The system according to claim 1 , wherein the control circuit comprises a non-volatile string of bits used as lot codes.4. The system according to claim 1 , wherein the controller of the meter is further programmed to perform a test utilizing the test strip and to inhibit the test strip after the test has been completed.5. The system according to claim 1 , wherein the control circuit is configured to measure a temperature of ...

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Номер записи: 31
17-03-2016 дата публикации

BIOCHIP AND DEVICE FOR MEASURING BIOCHIP

Номер: US20160077043A1
Автор: Yi Sang Hyun
Принадлежит: SAMSUNG ELECTRO-MECHANICS CO., LTD.

There is provided a biochip including: a first substrate having a first surface in which a plurality of grooves are provided to accommodate at least one type of culture medium therein, and including a first electrode which is connected to the plurality of grooves; and a second substrate having a first surface in which a plurality of biomaterial fixing parts are provided to attach at least one type of biomaterial thereto, and including a second electrode which is connected to the plurality of biomaterial fixing parts. The biochip can rapidly and precisely measure a reaction of the biomaterial. 1. A biochip comprising:a first substrate having a first surface in which a plurality of grooves are provided to accommodate at least one type of culture medium therein, and including a first electrode which is connected to the plurality of grooves; anda second substrate having a first surface in which a plurality of biomaterial fixing parts are provided to attach at least one type of biomaterial thereto, and including a second electrode which is connected to the plurality of biomaterial fixing parts.2. The biochip of claim 1 , wherein the first electrode is elongated in a second surface of the first substrate in a length direction of the first substrate claim 1 , andthe second electrode is elongated in a second surface of the second substrate in a length direction of the second substrate.3. The biochip of claim 1 , wherein the first electrode includes:a plurality of first internal electrodes extended from the plurality of grooves to a second surface of the first substrate; anda first external electrode disposed on the second surface of the first substrate and connected to the plurality of first internal electrodes.4. The biochip of claim 1 , wherein the first electrode includes:a plurality of first internal electrodes extended from the plurality of grooves to a second surface of the first substrate; anda plurality of first external electrodes disposed on the second surface of ...

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Номер записи: 32
15-03-2018 дата публикации

PHYSIOLOGICAL PARAMETER MEASUREMENT MODULE

Номер: US20180074041A1
Автор: Chen Ming-Ta, Liu Tung-Liang
Принадлежит: BIONIME CORPORATION

A test strip reader is disclosed. The test strip reader comprises a module main body and a circuit board. The module main body includes an upper cover, a grounding element and at least one operation hole containing a first operation movement assembly and a second operation movement assembly, wherein the upper cover and the module main body are formed integrally, and a condition of one of a contact status and a separation status between the second operation movement assembly and the grounding element determines a read signal. 2. The test strip reader as claimed in claim 1 , wherein the module main body further includes an upper strip contacting surface and a lower strip contacting surface to form a strip insertion slot integrally with the module main body for accommodating a test strip.3. The test strip reader as claimed in claim 2 , wherein the strip insertion slot has a height being equal to a standard thickness of the test strip plus a tolerance ranging between 0.05 and 0.5 millimeters.4. The test strip reader as claimed in claim 2 , wherein the test strip includes at least one protrusion having a protrusion height ranging between 0.4 and 0.8 millimeters.5. The test strip reader as claimed in claim 1 , wherein the first operation movement assembly includes an actuating element for contacting at least one coding recess on the test strip.6. The test strip reader as claimed in claim 5 , wherein the second operation movement assembly includes an elastic element.7. The test strip reader as claimed in claim 6 , wherein the circuit board is disposed below the elastic element.8. The test strip reader as claimed in claim 5 , wherein the first operation movement assembly further includes a blocking element disposed below the actuating element.9. The test strip reader as claimed in claim 6 , wherein the second operation movement assembly includes a conductive element disposed under the blocking element and the elastic element for pushing the conductive element.10. The test ...

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Номер записи: 33
07-03-2019 дата публикации

Medical analyte testing system and operating method therefor

Номер: US20190072574A1
Автор: Beate Koschorreck, Hans Kintzig, Max Berg
Принадлежит: Roche Diabetes Care Inc

A method for operating a medical analyte testing system having a handheld meter, particularly, a glucose meter, and a test magazine is disclosed. In the disclosed method a replaceable test magazine including a plurality of test elements is provided in the handheld meter for conducting successive analyte tests. An auxiliary measuring unit of the handheld meter measures at various points of time at least one ambient parameter, including temperature or humidity. The method checks for a threshold violation by comparing the measured ambient parameter with a preset threshold. The preset threshold is lowered after an initial period of use of the test magazine, and a use-up period is adjusted based on the check for a threshold violation.

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Номер записи: 34
17-03-2016 дата публикации

Smartphone-Based Apparatus and Method

Номер: US20160080548A1
Автор: "ODell Dakota", Erickson David, Lee Seoho, Mancuso Matthew, Mehta Saurabh, Oncescu Vlad-Victor
Принадлежит: CORNELL UNIVERSITY

A method for obtaining a point-of-collection, selected quantitative indicia of an analyte on a test strip using a smartphone involves imaging a test strip on which a colorimetric reaction of a target sample has occurred due to test strip illumination by the smartphone. The smartphone includes a smartphone app and a smartphone accessory that provides an external environment-independent/internal light-free, imaging environment independent of the smartphone platform being used. The result can then be presented quantitatively or turned into a more consumer-friendly measurement (positive, negative, above average, etc.), displayed to the user, stored for later use, and communicated to a location where practitioners can provide additional review. Additionally, social media integration can allow for device results to be broadcast to specific audiences, to compare healthy living with others, to compete in health based games, create mappings, and other applications. 1. A method for obtaining a point-of-collection , selected quantitative indicia of an analyte on a test platform , comprising:providing a modular, colorimetric reactive test platform having a test region and a calibration region;providing an analyte to be tested on the test region of the modular, colorimetric test platform, wherein the test region is adapted to enable a colorimetric reaction to the analyte;obtaining a color image of the test region containing the analyte and the calibration region;selecting an array of pixels in each of the color images of the test region containing the analyte and the calibration region;determining a median RGBA color value for each of the arrays of pixels;converting the median RGBA color value for each of the arrays of pixels to a respective Hue-Saturation-Luminosity (HSL or HSV) test color space value and a HSL or HSV calibration color space value;providing a calibration indicia that relates a selected quantitative indicia of the analyte to a characteristic of the HSL or HSV ...

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Номер записи: 35
18-03-2021 дата публикации

OPERATION AND VERIFICATION OF A PORTABLE CLINICAL ANALYSIS SYSTEM

Номер: US20210080449A1
Автор: Davis Graham, Emeric Pierre, Fetters Christopher, Soman Narendra, Vandersleen Gary, Wasserman Paul
Принадлежит: ABBOTT POINT OF CARE INC.

The present invention covers the integration and utility of accelerometer features into a clinical analysis system. For example, measurement of dynamic acceleration and orientation of a blood-testing instrument with respect to Earth's gravitational field may be used to determine reliability of a test procedure and optionally to provide corrective elements thereof. 1. A portable clinical system for in vitro analysis , the portable clinical system comprising:a cartridge configured to perform an in vitro analytical test; and a port configured to receive the cartridge,', 'a measurement module interfacing with the cartridge inserted into the port, the measurement module configured to perform a test cycle on the cartridge to conduct the in vitro analytical test on a sample, thereby generating a vibration profile for the test cycle of the cartridge; and', compare the generated vibration profile for the test cycle of the cartridge with a pre-established vibration profile,', 'determine whether the generated vibration profile for the test cycle of the cartridge deviates from the pre-established vibration profile, and', 'based on the comparison of the test cycle of the cartridge with the pre-established vibration profile, indicate whether the analyzer is functioning properly., 'a computing device configured to], 'an analyzer comprising'}2. The portable clinical system of claim 1 , wherein the pre-established vibration profile is a typical vibration profile for a similar cartridge.3. The portable clinical system of claim 1 , wherein the vibration profile for the test cycle of the cartridge comprises vibration from movement of one of more plungers of the analyzer when the analyzer performs the test cycle on the cartridge.4. The portable clinical system of claim 1 , wherein the vibration profile for the test cycle of the cartridge comprises acceptable variation from the pre-established vibration profile.5. The portable clinical system of claim 1 , wherein the computing device is ...

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Номер записи: 36
18-03-2021 дата публикации

NFC GLUCOMETER CONTAINING RECHARGEABLE BATTERY FOR INDEPENDED USEAGE

Номер: US20210080451A1
Автор: Klemm Thomas
Принадлежит:

The disclosure refers to a medical device comprising a measurement unit adapted to measure a value of a physiological parameter, for example a blood glucose level, an energy storage unit providing energy supply for the measurement unit, an NFC antenna, an energy supply unit that controls the NFC antenna such that in the presence of an electromagnetic field of a pre-defined frequency range energy is withdrawn from the electromagnetic field surrounding the NFC antenna and stored in the energy storage unit, a charge control unit adapted to determine the electric charge contained in the energy storage unit, and a communication unit adapted to output a pre-defined visible, audible and/or tactile signal if the electric charge contained in the energy storage unit determined by the charge control unit is equal to or below a pre-defined minimum charge value. 19-. (canceled)10. A medical device comprisingmeasurement unit adapted to measure a value or values of a physiological parameter;an energy storage unit connected with the measurement unit providing energy supply for the measurement unit;an NFC antenna;an energy supply unit connected to the NFC antenna and to the energy storage unit, wherein the energy supply unit controls the NFC antenna such that in the presence of an electromagnetic field of a pre-defined frequency range, energy is withdrawn from the electromagnetic field surrounding the NFC antenna and stored in the energy storage unit,a charge control unit, connected to the energy storage unit and adapted to determine an electric charge contained in the energy storage unit, anda communication unit connected with the charge control unit, wherein the communication unit is adapted to output a pre-defined visible, audible, and/or tactile signal if the electric charge contained in the energy storage unit determined by the charge control unit is equal to or below a pre-defined minimum charge value.11. The medical device according to claim 10 , wherein the charge control ...

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Номер записи: 37
26-03-2015 дата публикации

PORTABLE DEVICE ASSEMBLY FOR MEASURING BLOOD SAMPLES AND A DEVICE COVER

Номер: US20150083590A1
Автор: KOSKI Salla, RAJALA Carina, TASANEN Mikko
Принадлежит: Modz Oy

A device assembly for measuring and monitoring glucose content of blood, and a cover of such an assembly. The assembly is especially applicable for users with diabetes disease. The assembly includes a resilient cover on a measurement device. The cover has a slit at the input for a blood sample strip. The slit is closed at its rest position, but a test strip can be entered through the slit based on the resilience of the cover material. The resilient cover absorbs possible mechanical impacts and prevents impurities from reaching the sensor electronics. 111-. (canceled)12301424251313524. A user portable measurement device assembly () , which comprises a measurement unit () for measuring a blood sample for e.g. blood glucose concentration , wherein the measurement unit has an input () for providing the blood sample strip in the measurement unit , and the device has a user interface () for presenting to a user information which is based on a measurement result , wherein the assembly comprises a resilient cover () for the measurement device which cover has a slit () at the input () for the blood sample strip , and the slit is at least as wide as the width of the blood sample strip , whereby the slit is arranged to be substantially closed in its rest position , and allows a blood sample strip to be entered through the slit based on the resilience of the cover material.1331. A measurement device assembly according to claim 12 , wherein the resilient cover () is made of silicone claim 12 , plastic or fabric.1431. A measurement device assembly according to claim 12 , wherein at least part of the resilient cover () is made of translucent material.1572721312435. A measurement device assembly according to claim 12 , wherein the measurement device has means ( claim 12 , ) for lighting the sample input claim 12 , whereby the resilient cover () is illuminated at the area of the sample strip input ( claim 12 , ).1634. A measurement device assembly according to claim 12 , wherein the ...

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Номер записи: 38
23-03-2017 дата публикации

DIGITAL PATCH-CLAMP AMPLIFIER

Номер: US20170082600A1
Автор: Lobdill Rich
Принадлежит: Sutter Instrument Company

Patch-clamp amplifiers that may be readily manufactured, may be simple to reconfigure for product updates, and can be quickly reconfigured into a different mode during operation. One example may provide patch-clamp amplifiers that may be readily manufactured by implementing some or all of the compensation and other circuits using digital circuitry. These digital circuits may be implemented using discrete or integrated logic circuits, programmable logic such as field-programmable gate arrays or programmable logic arrays, or other fixed or configurable logic circuits or combination thereof. These programmable logic circuits may be reconfigured by a user or by a manufacturer through firmware or software updates when a product update is desired. These circuits may also be quickly reconfigured to allow rapid switching between modes during use. 1. An electronic device comprising:a digital waveform generator to provide a digital waveform;a series resistance compensation circuit to receive the digital waveform and to provide a first output;a first converter to convert the first output of the series resistance compensation circuit to a first analog voltage;a pipette compensation and whole-cell compensation circuit to receive the output of the series resistance compensation and the digital waveform and to provide a first output and a second output;a second converter to convert the first output of the pipette compensation and whole-cell compensation circuit to a second analog voltage;a third converter to convert the second output of the pipette compensation and whole-cell compensation circuit to a third analog voltage; anda first analog circuit to receive the first analog voltage, the second analog voltage, and the third analog voltage and to provide a fourth analog voltage,wherein the series resistance compensation circuit further receives the fourth analog voltage.2. The electronic device of wherein the digital waveform is a pulsed waveform.3. The electronic device of ...

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Номер записи: 39
23-03-2017 дата публикации

Sample dispenser including an internal standard and methods of use thereof

Номер: US20170082604A1
Автор: HE Wang, Jiangjiang Liu, Nicholas E. Manicke, Qian Yang, Robert Graham Cooks, Zheng Ouyang
Принадлежит: PURDUE RESEARCH FOUNDATION

The invention generally relates to a sample dispenser including an internal standard and methods of use thereof.

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Номер записи: 40
12-03-2020 дата публикации

BIOFLUID SENSING DEVICE CYTOKINE MEASUREMENT

Номер: US20200080987A1
Автор: Begtrup Gavi, Cunningham Kathy, Katchman Benjamin
Принадлежит: Eccrine Systems, Inc.

The present disclosure provides a method of using a wearable biofluid sensing device to develop a cytokine profile for an individual. The method includes taking concentration, ratio, and trend measurements of one or more cytokines in the individual's sweat, along with other contemporaneous device measurements to inform sweat rate, skin temperature, sweat sample pH, or other factors. The method further considers these measured values in the context of external information about the individual, and uses such information to develop (1) a baseline cytokine profile characterizing the individual's healthy cytokine levels, or (2) an inflammation profile for a physiological condition, which characterizes the expected cytokine levels for a physiological condition. Also included is a method to use a biofluid sensing device to determine whether an individual has a physiological condition by comparing device measurements to the baseline profile and inflammation profile. Results are then communicated to a device user. 1. A method of using a wearable biofluid sensing device , comprising:taking one or more cytokine measurements of one or more cytokines in a sweat sample taken from an individual;taking one or more secondary measurements of the sweat sample;developing a cytokine profile based on the one or more cytokine measurements, the one or more secondary measurements, and one or more characteristics of the individual; andcommunicating said cytokine profile to a device user.2. The method of claim 1 , wherein the cytokine profile is one of the following: a baseline profile claim 1 , comprising a set of cytokine values representing a healthy physiological state; and an inflammation profile claim 1 , comprising a set of cytokine values representing one of: a presence of inflammation claim 1 , an absence of inflammation claim 1 , or a severity of inflammation.3. The method of claim 1 , wherein the cytokine profile is developed for a group of persons claim 1 , wherein each person in ...

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Номер записи: 41
29-03-2018 дата публикации

SYSTEM AND APPARATUS FOR DETERMINING AMBIENT TEMPERATURES FOR A FLUID ANALYTE SYSTEM

Номер: US20180087972A1
Автор: Wu Mu
Принадлежит:

A system and method for rapidly determining ambient temperature in a fluid-analyte meter. The meter includes a housing defining an interior space and an area for receiving a fluid sample. A processor and a first temperature sensor are disposed within the interior space of said the housing. A second temperature sensor is disposed on the housing. One or more processors are configured to determine a first temperature value from temperature data received from the first temperature sensor. The processor(s) are also configured to apply a variable current to a temperature-adjustment source such that the second temperature sensor is adjusted to a predetermined steady-state temperature value different from the first temperature value. The processor(s) are further configured to determine an ambient temperature of an exterior space of the housing based on the applied variable current, pre-determined steady-state temperature, and received first temperature values. 126-. (canceled)27. A portable meter configured to rapidly determine ambient temperature , the portable meter comprising:a housing defining an interior space and an area for receiving a fluid sample;a first processing unit and a first temperature sensor disposed within said interior space of said housing; anda second temperature sensor disposed on said housing; and determine a first temperature value from temperature data received from said first temperature sensor,', 'apply a variable current to a temperature-adjustment source such that said second temperature sensor is adjusted to a predetermined steady-state temperature value different from said first temperature value, and', 'determine an ambient temperature of an exterior space of said housing based on said applied variable current, said pre-determined steady-state temperature value, and said received first temperature value., 'said first processing unit or another processing unit being configured to28. The portable meter of claim 27 , wherein said second ...

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Номер записи: 42
21-03-2019 дата публикации

SYSTEM AND APPARATUS FOR DETERMINING AMBIENT TEMPERATURES FOR A FLUID ANALYTE SYSTEM

Номер: US20190086271A1
Автор: Wu Mu
Принадлежит:

A system and method for rapidly determining ambient temperature in a fluid-analyte meter. The meter includes a housing defining an interior space and an area for receiving a fluid sample. A processor and a first temperature sensor are disposed within the interior space of said the housing. A second temperature sensor is disposed on the housing. One or more processors are configured to determine a first temperature value from temperature data received from the first temperature sensor. The processor(s) are also configured to apply a variable current to a temperature-adjustment source such that the second temperature sensor is adjusted to a predetermined steady-state temperature value different from the first temperature value. The processor(s) are further configured to determine an ambient temperature of an exterior space of the housing based on the applied variable current, pre-determined steady-state temperature, and received first temperature values. 126-. (canceled)27. A portable meter configured to rapidly determine ambient temperature , the portable meter comprising:a housing defining an interior space and an area for receiving a fluid sample;a controller and a first temperature sensor disposed within said interior space of said housing; anda second temperature sensor disposed on said housing; determine a first temperature value from temperature data received from said first temperature sensor,', 'apply a variable current ranging between 1 mA to 200 mA to a temperature-adjustment source such that said second temperature sensor is adjusted to a predetermined steady-state temperature value up to about 10 degrees Celsius greater than said first temperature value, and', 'determine an ambient temperature of an exterior space of said housing based on said applied variable current, said pre-determined steady-state temperature value, and said received first temperature value,', 'wherein the ambient temperature is determined to within about ±1 degree Celsius of an ...

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Номер записи: 43
05-04-2018 дата публикации

HAND-HELD TEST METER WITH ANALYTICAL TEST STRIP CONTACT PRESSURE FEATURE

Номер: US20180095049A1
Автор: ELDER David, LONGMUIR Alistair, Nelson Jonathan
Принадлежит:

A hand-held test meter for use with an analytical test strip (such as an electrochemical-based analytical test strip) for the determination of an analyte (e.g., glucose) in a bodily fluid sample, the hand-held test meter including a housing with an analytical test strip contact pressure feature, a printed circuit board (PCB) with at least one solder bump disposed in the housing. The housing of the hand-held test meter is configured for the insertion of an analytical test strip therein. In addition, the analytical test strip contact pressure feature is configured to operatively apply pressure on the inserted analytical test strip such that at least one electrical contact of the inserted analytical test strip is operably pressed against the solder bump, thereby creating a direct operable electrical connection between the inserted analytical test strip and the solder bump of the PCB. 2. The hand-held test meter of wherein the at least one solder bump is electrically connected to the micro-controller.3. The hand-held test meter of wherein the at least one analytical test strip contact pressure feature is a plurality of analytical test strip contact pressure features.4. The hand-held test meter of wherein the at least one solder bump is a plurality of solder bumps.5. The hand-held test meter of wherein the wherein the plurality of analytical test strip contact pressure features are configured to operatively apply pressure on an inserted analytical test strip such that each of a plurality of electrical contacts of the inserted analytical test strip is operably pressed against the plurality of solder bumps in a predetermined manner thereby creating a plurality of direct distinct operable electrical connections between the analytical test strip and the plurality of solder bumps of the PCB.6. The hand-held test meter of wherein the housing is formed of a polymeric material.7. The hand-held test meter of wherein the analytical test strip pressure feature is an analytical test ...

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Номер записи: 44
05-04-2018 дата публикации

Electrode Assembly for Measurement of Platelet Function in Whole Blood

Номер: US20180095065A1
Автор: Cory Lee McCluskey, Michael M. Gorin, Robert Hillman
Принадлежит: CA Casyso AG

A platelet impedance measurement system including an electrode assembly allows for measurement of platelet function in blood. The assembly includes a substrate that acts as a substantially rigid base and includes an electrode. A portion of the electrode is exposed such that, when the electrode is placed in blood, the exposed portion is in contact with the blood for measuring impedance changes as platelets adhere to the electrode. Wires of the electrode can be attached to each end of the substrate and can run within a groove along a portion of the substrate. The substrate includes an open area where the wires in the groove exit and re-enter the substrate at the end of the substrate, allowing the wires to be exposed to the blood. The open area includes a brace, ensuring that the exposed wires are held in the appropriate placement relative to each other and to the cuvette.

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Номер записи: 45
14-04-2016 дата публикации

SYSTEM AND METHOD FOR DETECTING USED AND DRIED SENSORS

Номер: US20160103090A1
Автор: Harrison Bern
Принадлежит:

Systems and methods for detecting dried test strips are provided, where a dried test strip may be one that has been re-inoculated with a biological sample after having already been previously inoculated with another sample at an earlier time (e.g., hours or days before). In various aspects, a biosensor such as an amperometric glucose biosensor (“meter”) may apply one or more input electrical signals to an inoculated test strip having at least a pair of electrodes in contact with the biological sample. The meter may measure output current value(s) resulting in response to the input electrical signals applied to the test strip. The meter may determine whether the test strip is a dried test strip by comparing a ratio of the measured output current value(s) with a boundary ratio value. 1. A method of analyzing a test strip in a biosensor , the method comprising:displaying a procedural message to apply a liquid sample to a test strip, the test strip having a dry reagent, a working electrode, a counter electrode, a detection electrode, and a bare electrode that is not in contact with the dry reagent in an unused condition of the test strip;applying a first voltage between the working electrode and the counter electrode;measuring a first current between the working electrode and the counter electrode;determining an amount of an analyte based on the measured first current;applying a second voltage between the bare electrode and the working electrode after the applying the first voltage; displaying a first error message and inhibiting a display of the determined amount of the analyte in response to a calculation based on the second and third measured currents being below a first threshold; and', 'displaying the determined amount of analyte in response to the calculation being above the first threshold., 'measuring a second current and thereafter a third current between the bare electrode and the working electrode; and at least one of2. The method of claim 1 , wherein the ...

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Номер записи: 46
03-07-2014 дата публикации

MICRO-FLUIDIC DEVICE FOR THE ANALYSIS OF A FLUID SAMPLE

Номер: US20140186820A1
Автор: QUEVAL Arthur
Принадлежит:

Use of a programmable device with capacitive touch screen for the analysis of a fluid sample as interface between a micro-fluidic device, this micro-fluidic device comprising at least one electrode and at least one micro-channel comprising an input for the introduction of the sample, and the processor of said programmable device with a capacitive touch screen. 1. Micro-fluidic device for analyzing a fluid sample , comprising:at least one electrode;at least one surface close to said electrode, for placing said fluid sample;wherein said at least one electrode is arranged so as to produce a measurable capacitance variation on the touch screen of a programmable device with capacitive touch screen when said device is placed on said touch screen, so as to enable the analysis of said fluid sample.2. The micro-fluidic device of claim 1 , wherein said surface is formed on at least one micro-channel comprising an input for the introduction of said sample.3. The device according to claim 1 , made of polymer by means of a micro-manufacturing method.4. The device according to claim 1 , comprising at least one micro-valve and/or at least one pump.5. The device according to claim 4 , designed for being coupled with an external electronics for signal amplification and/or for actuating said at least one pump.6. The device according to claim 2 , comprising a detection surface between said input and an output of said micro-channel.7. The device according to claim 2 , comprising at least one said electrode on the side of said micro-channel opposite said programmable device and at least one said electrode on the opposite side of said micro-channel.8. The device according to claim 1 , comprising at least one outer surface opposite said electrode on which said sample is intended to be placed directly for the test.9. The device according to claim 1 , wherein said surface enabling said fluid sample to be placed is functionalized chemically so as to enable the adhesion of specific molecules ...

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Номер записи: 47
03-07-2014 дата публикации

Module for a computer interface

Номер: US20140187891A1
Автор: Erich Imhof, Ulrich Haueter
Принадлежит: ROCHE DIAGNOSTICS INTERNATIONAL AG

The present invention provides a module for a computer interface including a transducer wherein the transducer receives a measurement value and makes this measurement value available for monitoring an individual's health by means of the computer interface, for example, for monitoring an individual's blood glucose level, wherein the measurement value is obtained by means of a sensor.

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Номер записи: 48
26-04-2018 дата публикации

Automated Driving of an Assay

Номер: US20180113126A1
Автор: Chatterjee Dev, Heffernan Michael John, III Leo, LlNBECK, Varadhachary Atul
Принадлежит:

The invention herein relates to conducting assays with an apparatus including a substantially transparent assay cartridge loaded with magnetic beads, and a magnet carrier base positioned below a scanning platform holding the assay cartridge. The assay cartridge includes magnetic beads, sample and control solutions in some wells, and assay reagents in others. A microcomputer controls a stepping motor which controls movement of the magnet carrier base, and causes the magnetic beads to travel from one well to another. An electromagnetic coil-spring assembly induces mixing of well contents with the magnetic beads on actuation. The assay cartridge is authenticated by sending its encoded identifier to a server or website, and assay instructions are provided remotely to the microcomputer. Following assay completion, the cartridge can have color change or other assay indication detected, and the results sent to the server or website or another recipient. 125-. (canceled)26. An apparatus for performing an assay where magnetic beads are moved through a plurality of wells which contain assay reagents , comprising:a substantially planar assay cartridge having a plurality of wells which are indentations in a first substantially planar surface of said cartridge, and said wells are separated and are connected by channels running between wells; andat least one scanning magnet positioned to attract one or more sets of magnetic beads in the wells and move them with movement of the scanning magnet, anda motor moves the at least one scanning magnet with respect to the assay cartridge along a first axis and a coil is actuated and de-actuated to oscillate said at least one scanning magnet along a second axis, wherein said first axis intersects the second axis.27. The apparatus of claim 26 , wherein the at least one scanning magnet is held in a magnet holder which is held by a base claim 26 , and wherein the magnet holder is moveable with respect to the base along the second axis.28. The ...

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Номер записи: 49
27-04-2017 дата публикации

Apparatus for Diagnostic Meter Strip Control and Identification

Номер: US20170115270A1
Автор: Combs Bradley, Leone Steven V., Modzelewski Brent E.
Принадлежит:

A system for measuring a property of a sample in a liquid which includes a test strip and a meter is provided. Some embodiments relate to a diagnostic test strip for collecting a sample, the strip having a plurality of electrodes for measuring a property of the sample, and the strip having a control circuit at a distal region of the strip, the control circuit configured to communicate with a controller of a meter, the control circuit including an embedded temperature sensor, a memory for lot coding and authentication of the test strip, and an inhibit logic for inhibiting the test from being used more than once; and a diagnostic meter for receiving the test strip, the meter having a controller programmed to communicate with the control circuit. 1. A diagnostic test strip comprising:a substrate;a plurality of electrodes for measuring a property of a sample and disposed at a proximal region of the substrate; anda control circuit disposed at a distal region of the substrate, the control circuit being connected to the electrodes and configured to communicate with a controller of a meter, the control circuit including an embedded temperature sensor, a memory for lot coding and authentication of the test strip, and an inhibit logic for inhibiting the test strip from being used after removal of the test strip from the meter.2. The test strip according to claim 1 , wherein the control circuit comprises a non-volatile string of bits used to identify the strip as authentic.3. The test strip according to claim 1 , wherein the control circuit comprises a non-volatile string of bits used as lot codes.4. The test strip according to claim 1 , wherein the control circuit is configured to measure a temperature of the test strip claim 1 , wherein the control circuit is programmed to communicate to the controller to adjust a test measurement based on the temperature of the test strip.5. The test strip according to claim 1 , wherein the control circuit is configured to store an error ...

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Номер записи: 50
03-05-2018 дата публикации

MEDICAL INSTRUMENT WITH SHUTTER FOR SEALING A TEST STRIP PORT

Номер: US20180120289A1
Автор: Fischheiter Lars, Stein Reiner, Thome Klaus
Принадлежит: ROCHE DIAGNOSTICS OPERATIONS, INC.

A medical instrument/analyzer for measuring a biological sample using a test strip. The instrument comprises: a housing with an exterior surface, an internal surface, and an interior volume; an analytical unit within the interior volume with a test strip mount; a test strip port between the exterior and the interior surfaces; a shutter configured for sealing the test strip port when closed, wherein the shutter comprises a test strip support aligned with the test strip port and mount when the shutter is in the open position, wherein the shutter has a first sealing surface, the test strip port has a second sealing surface, and the first sealing and second sealing surfaces are configured to mate in the closed position, wherein the shutter comprises a mechanism for moving between the open and the closed position; and an actuator configured for moving the shutter between the open and closed position. 2. A medical instrument , wherein the medical instrument is an analyzer for performing a measurement on a biological sample using a test strip , wherein the medical instrument comprises:a housing with an exterior surface, wherein the housing comprises an internal surface surrounding a interior volume;an analytical unit for analyzing the test strip, wherein the analytical unit is within the interior volume, wherein the analytical unit comprises a test strip mount configured for receiving the test strip to perform the measurement;a test strip port between the exterior surface and the interior surface, wherein the test strip port is configured for receiving the test strip, wherein the test strip port is aligned with the test strip mount along an insertion direction;a shutter for sealing the test strip port, wherein the shutter is configured for being in a open position and a closed position, wherein the shutter is within the interior volume, wherein the shutter is configured for sealing the test strip port when in the closed position, wherein the shutter comprises a test strip ...

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Номер записи: 51
25-08-2022 дата публикации

MODULAR HAND-HELD POINT OF CARE TESTING SYSTEM

Номер: US20220268758A1
Автор: Adelman Lonnie W.
Принадлежит:

A modular hand-held point of care testing system, which includes a plurality of different assay adapters configured to receive a plurality of different assay devices that perform assays on one or more samples; a shared door that that interchangeably receives the plurality of different assay adapters; wherein at least two of the plurality of assay adapters or at least two of the assay devices comprise different identifiers that distinguish the assays from each other; an apparatus comprising a portable frame configured to interchangeably receive the shared door and a means for decoding the different identifiers when received by the frame; and a means for reading assay results. 1. A modular hand-held point of care testing system , comprising:(a) a plurality of different assay adapters configured to receive a plurality of different assay devices that perform assays on one or more samples;(b) a shared door that that interchangeably receives the plurality of different assay adapters; wherein at least two of the plurality of assay adapters or at least two of the assay devices comprise different identifiers that distinguish the assays from each other;(c) an apparatus comprising a portable frame configured to interchangeably receive the shared door and a means for decoding the different identifiers when received by the frame; and(d) a means for reading assay results.2. The system of claim 1 , wherein the different identifiers are differently ordered teeth and the means for decoding the different identifiers is a photointerrruptor.3. The system of claim 1 , wherein the different identifiers comprise RFID or NFC circuits claim 1 , further wherein the means for decoding the different identifiers comprises a corresponding RFID or NFC reader.4. The system of claim 1 , wherein the different identifiers comprise different indicia claim 1 , selected from the group consisting of a bar code claim 1 , a QR code claim 1 , and an alphanumeric code claim 1 , further wherein the means for ...

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Номер записи: 52
16-04-2020 дата публикации

APPARATUS AND METHOD FOR STORING THIN FILM DEVICE AND METHOD FOR MEASURING BIOLOGICAL MOLECULE

Номер: US20200116697A1
Автор: Fujioka Michiru, Goto Yusuke, MATSUI Kazuma
Принадлежит:

An apparatus for storing a thin film device, the apparatus including: a thin film device having an insulating thin film containing Si and having a thickness of 100 nm or less; a solution in contact with the thin film; and a container having a tank that seals the solution, wherein the solution is a solution that satisfies any of the following conditions (1) to (3). 1. An apparatus for storing a thin film device , the apparatus comprising:a thin film device having an insulating thin film containing Si and having a thickness of 100 nm or less;a solution in contact with the thin film; anda container having a tank to seal the solution,wherein the solution satisfies any of conditions (1) to (3):(1) a solution containing water in a volume ratio of 0% or more to 30% or less;(2) a solution cooled and maintained at a temperature equal to or higher than a solidification point and lower than 15° C.; and(3) a solution that contains a salt with a concentration of 1 mol/L or more and a saturation concentration or less, and is cooled and maintained to a temperature equal to or higher than a solidification point and lower than 25° C.2. The apparatus for storing the thin film device according to claim 1 , further comprising a container having a first tank and a second tank disposed with the thin film device interposed therebetween claim 1 ,wherein the solution in contact with the thin film is sealed in each of the first tank and the second tank.3. The apparatus for storing the thin film device according to claim 1 , further comprising a mechanism to adjust a temperature of the solution.4. The apparatus for storing the thin film device according to claim 1 , whereinthe solution satisfies any of conditions (4) to (6):(4) a solution containing water in a volume ratio of 0% or more to 5% or less;(5) a solution cooled and maintained at a temperature equal to or higher than a solidification point and lower than 5° C.; and(6) a solution that contains a salt with a concentration of 1 mol/L ...

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Номер записи: 53
02-05-2019 дата публикации

MICRONEEDLE ARRAYS FOR BIOSENSING AND DRUG DELIVERY

Номер: US20190125223A1
Автор: Edwards Thayne L., Miller Phillip, Narayan Roger, Polsky Ronen, Wang Joseph, Windmiller Joshua Ray
Принадлежит:

Methods, structures, and systems are disclosed for biosensing and drug delivery techniques. In one aspect, a device for detecting an analyte and/or releasing a biochemical into a biological fluid can include an array of hollowed needles, in which each needle includes a protruded needle structure including an exterior wall forming a hollow interior and an opening at a terminal end of the protruded needle structure that exposes the hollow interior, and a probe inside the exterior wall to interact with one or more chemical or biological substances that come in contact with the probe via the opening to produce a probe sensing signal, and an array of wires that are coupled to probes of the array of hollowed needles, respectively, each wire being electrically conductive to transmit the probe sensing signal produced by a respective probe. 1. An analyte-selective sensor device for measuring an analyte in a physiological fluid , comprising:a substrate having an anterior surface and a posterior surface;an array of electrically-insulating protruded needle structures arranged perpendicularly and extending from the anterior surface of the substrate to a distal extent of 1500 micrometers or less from the posterior surface of the substrate;an array of electrically-conductive probes, each probe disposed within and circumscribed by a corresponding electrically-insulating protruded needle structure, wherein the electrically-conductive probes extend perpendicularly from the anterior surface of the substrate to a region beyond the distal extent of the electrically-insulating protruded needle structures;an array of electrically-conductive interconnects, each interconnect coupled to a corresponding electrically-conductive probe at the anterior surface of the substrate; andan array of electrodes, each electrode disposed on a surface of a corresponding electrically-conductive probe in the region beyond the distal extent of the electrically-insulating protruded needle structure, wherein at ...

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Номер записи: 54
23-04-2020 дата публикации

URINALYSIS DEVICE AND TEST STRIP FOR HOME AND POINT OF CARE USE

Номер: US20200124587A1
Автор: Dechev Nikolai, Dechev Teodora
Принадлежит: YOUCOUNT INC.

A urinalysis device for non-clinical use is provided, the device comprising: a housing; a touchscreen on the housing; a test strip holder, which is removably, slidably engaged with the housing; at least two light emitting diode (LED) light sources, housed in the housing and including a white LED and a red-blue-green (RBG) LED; a camera module housed in the housing, both the plurality of LEDs and the camera module directed to an illumination and detection zone; a timer system; and a computational system, the computational system in electronic communication with the plurality of LEDs, the camera module and the timer system, the computational system including a processor and a memory. 1. A urinalysis device for non-clinical use , the device comprising: a housing defining an interior , the housing including a front , a back opposite the front , a top , a bottom opposite the top and a pair of sides between the front and the back and the top and the bottom , one of the pair of sides including an aperture extending between an ambient environment and the interior; a slide which extends from the aperture into the interior; a touchscreen on the housing; a test strip holder , which is removably , slidably engaged with the slide; at least two light emitting diode (LED) light sources , housed in the housing and including a white LED and a red-blue-green (RBG) LED; a camera module housed in the housing , both the plurality of LEDs and the camera module directed to an illumination and detection zone; a timer system; and a computational system , the computational system in electronic communication with the plurality of LEDs , the camera module and the timer system , the computational system including a processor and a memory.2. The device of claim 1 , wherein the LEDs include an ultraviolet (UV) LED.3. The device of claim 2 , wherein the slide includes a distal stop and a pair of rails along a length of the slide for locating the test strip holder in the illumination and detection ...

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Номер записи: 55
19-05-2016 дата публикации

Event-driven coulter counter ic for high throughput particle counting

Номер: US20160139024A1
Автор: Seong-jin Kim
Принадлежит: Agency for Science Technology and Research Singapore

A particle occurrence sensing circuit for microfluidic particle sensing includes a set of particle event indicators, each of which includes: a Coulter counter having a sensing electrode exposable to a fluid within a microfluidic channel and configured for providing a particle sensing signal; an input stage configured for providing an extracted particle sensing signal; and a particle event detector configured for providing a set of particle event occurrence signals. Each of the set of particle event occurrence signals indicates a sensed occurrence of a particle greater than or equal to a given reference particle size during fluid flow through the microfluidic channel to which the sensing electrode is exposed. The particle event detector includes a successive approximation (SA) analog-to-digital converter (ADC) configured for generating a plurality of reference particle size threshold values and successively comparing the extracted particle sensing signal amplitude with reference particle size threshold values.

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Номер записи: 56
03-06-2021 дата публикации

DIAGNOSTIC STRIP AND DIAGNOSTIC SYSTEM USING THE SAME

Номер: US20210164963A1
Автор: HAN Da Woon, KIM Gyu Min, Lee Dong Hoon
Принадлежит: QSTAG CO., LTD.

A diagnostic strip for reacting with a target for diagnosis, including: a connector configured to be connected to a power providing unit and provide a driving power to the diagnostic strip; an entry path configured to transfer a body fluid including the target; a reaction unit configured to react with the target and whose electrical characteristic is changed by the reaction; and a display unit configured to receive the driving power and whose display state is changed according to the changed electrical characteristic of the reaction unit. 1. A diagnostic strip for reacting with a target for diagnosis , the diagnostic strip comprising:a connector configured to be connected to a power providing unit and provide a driving power to the diagnostic strip;an entry path configured to transfer a body fluid including the target;a reaction unit configured to react with the target and whose electrical characteristic is changed by the reaction; anda display unit configured to receive the driving power and whose display state is changed according to the changed electrical characteristic of the reaction unit.2. The diagnostic strip of claim 1 , wherein the connector is any one of a male connector which is inserted into the power providing unit and a female connector into which the connector connected to the power providing unit is inserted.3. The diagnostic strip of claim 1 , wherein the connector is any one of a connector conforming to a universal serial bus (USB) standard and a lightning connector.4. The diagnostic strip of claim 1 , wherein the entry path includes at least one of a capillary for transferring the body fluid to the reaction unit and an exposure unit for exposing the reaction unit so that the body fluid is dropped thereon.5. The diagnostic strip of claim 1 , further comprising an environmental sensor unit configured to detect environmental influence on the reaction between the target and the reaction unit.6. The diagnostic strip of claim 5 , wherein the ...

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Номер записи: 57
03-06-2021 дата публикации

PORTABLE CLINICAL ANALYSIS SYSTEM FOR IMMUNOMETRIC MEASUREMENT

Номер: US20210164968A1
Автор: Davis Graham, Emeric Pierre, Miller Cary, Soman Narendra, Vandersleen Gary, Wasserman Paul
Принадлежит: ABBOTT POINT OF CARE INC.

The present invention covers the integration and utility of accelerometer features into a clinical analysis system. For example, measurement of dynamic acceleration and orientation of a blood-testing instrument with respect to Earth's gravitational field may be used to determine reliability of a test procedure and optionally to provide corrective elements thereof. 1. A system comprising:a test device comprising an immunosensor for performing an immunoassay on a sample; and executing a test cycle of the test device to perform the immunoassay on a sample using the immunosensor;', 'determining a spatial orientation and/or a rate of motion of the analyzer during the test cycle of the test device based on the data collected by the accelerometer during the test cycle;', 'determining a stage of the test cycle during which the data was collected by the accelerometer;', 'determining, based on the stage of the test cycle, a threshold operating spatial plane and/or a threshold rate of motion of the test device;', 'determining whether, during the stage of the test cycle: (i) the spatial orientation of the analyzer deviates from the threshold operating spatial plane, and/or (ii) the rate of motion of the analyzer exceeds the threshold rate of motion; and,', 'in response to determining that the spatial orientation deviates from the threshold operating spatial plane and/or that the rate of motion of the analyzer exceeds the threshold rate of motion, executing an operation, the operation comprising: (i) providing an alert prompting a user to take corrective action during the test cycle, (ii) correcting a result of the immunoassay, and/or (iii) suppressing the result of the immunoassay., 'an analyzer comprising: (i) a port for receiving the test device, (ii) an accelerometer for collecting data during performance of the immunoassay on the sample, (iii) one or more data processors, and (iv) a non-transitory computer readable storage medium containing instructions which, when executed ...

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Номер записи: 58
24-05-2018 дата публикации

Mobile Sickle Cell Diagnostic Tool

Номер: US20180143179A1
Автор: Aitaru Rachel Olema, Nanziri Bonita Beatrice
Принадлежит:

Implementing a mobile device configured to detect sickle cell traits in a blood sample. The device comprises a mobile device with a camera operatively coupled to a microscope lens. An image converter configured to receive an image form the camera and to perform a noise reduction procedure. The noise reduction procedure manipulates the image to a monochrome image and applies a Gaussian filter. A contour detector detects the contours of the image. An image analysis tool is configured to analyze the contours to identify discrete blood cells and clustered blood cells. The user is then notified if sickle cell traits are present based at least on the shape of the discrete blood cells. 1. A mobile device for identifying sickle cells in an image of a blood smear comprising:a microscope lens operatively coupled to a camera; converting a color base of the image to monochrome;', 'applying a Gaussian filter;, 'an image converter configured to receive an image from the camera and to perform a noise reduction procedure, wherein the noise reduction procedure comprisesa contour detector to detect contours in the converted image;an image analysis tool configured to analyze the contours to identify discrete blood cells and clustered blood cells; andnotification mechanism configured to notify a user that sickle cell traits are present based on at least a shape of the discrete blood cells.2. The mobile device of claim 1 , further comprising a light source configured to provide light in a predetermined light range.3. The mobile device of claim 1 , wherein the image analysis tool configured to identify substantially round particles as normal red blood cells.4. The mobile device of claim 1 , wherein the image analysis tool configured to identify substantially elliptical blood cells as sickle cells.5. The mobile device of claim 4 , wherein the identification of sickle cells is based in part on patient attributes comprising age.6. The mobile device of claim 1 , wherein clustered blood cells ...

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Номер записи: 59
21-08-2014 дата публикации

DIAGNOSTIC APPARATUS

Номер: US20140233098A1
Автор: Bresolin Stefano, Calderwood David A., Heineck Tobias M., Newcomb David, Paul Chris, Pollard Jasper N., Rodriguez Rodolfo R., Young Demetris
Принадлежит:

An automated microscope apparatus comprises an outer housing having an external wall; optionally but preferably an internal wall in the housing configured to form a first compartment and a separate second compartment in the outer housing; a microscope assembly in the housing (preferably in the first compartment); a microprocessor in the housing (preferably in the second compartment), and (optionally but preferably) a heat sink mounted on the housing external wall, preferably adjacent the second compartment, with the microprocessor thermally coupled to said heat sink and operatively associated with the microscope assembly. Systems and methods employing the same are also described, along with component parts thereof. 1. An automated microscope apparatus , comprising:an outer housing having an external wall;an internal wall in said housing, and configured to form a first compartment and a separate second compartment in said outer housing;a heat sink mounted on said housing external wall adjacent said second compartment;a microscope assembly in said first compartment; anda microprocessor in said second compartment, with said microprocessor thermally coupled to said heat sink and operatively associated with said microscope assembly.2. The apparatus of claim 1 , said microscope assembly comprising:a support framea subframe;a plurality of vibration isolators connecting said support frame to said subframe;an XYZ stage connected to said subframe; andan optical stage connected to said subframe.3. The apparatus of claim 2 , further comprising an XYZ drive interconnecting said XYZ stage to said subframe.4. The apparatus of claim 1 , further comprising a passively cooled microprocessor assembly claim 1 , comprising:a heat sink having a front surface and back surface;a circuit board having a front surface and back surface, with said microprocessor mounted on said circuit board front surface;a thermal coupler positioned between said microprocessor and said heat sink back surface, ...

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Номер записи: 60
31-05-2018 дата публикации

Lateral flow assay reader based on human perception and method relating thereto

Номер: US20180149600A1
Автор: Robert P. Farrell
Принадлежит: Idexx Laboratories Inc

An instrument for reading a lateral flow assay device by detecting color changes based on human perception includes an optics module having a camera, a signal processor, a storage memory and a comparator circuit. The storage memory has stored therein a dataset of sample readings of reference assay devices similar in structure and function to that of the lateral flow assay device. The sample readings are based on human visual perceptions of colorimetric changes in the detection zones of the reference assay devices. The comparator circuit compares the measured colorimetric data relating to the assay device read by the instrument with the stored database of sample readings based on human visual perceptions of the colorimetric changes of the reference assay devices, and generates a comparison signal which is provided to the signal processor. The signal processor generates a determination signal indicative of the presence, absence or quantity of an analyte.

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Номер записи: 61
11-06-2015 дата публикации

APPARATUS AND METHODS FOR REDUCING ELECTRICAL SHOCK HAZARD FROM BIOSENSOR METERS

Номер: US20150160187A1
Автор: Gofman Igor
Принадлежит:

A biosensor meter () is provided for determining an analyte concentration in a fluid, such as glucose in blood. The biosensor meter includes a USB port () having a first data signal port terminal (′), and a detection circuit () including a first input terminal and an output terminal. The first input terminal of the detection circuit () is coupled to the first data signal port terminal (′). The detection circuit () provides at the output terminal a first output signal when a current sensed at the first input terminal is greater than or equal to a first predetermined amount, and a second output signal when the current sensed at the first input terminal is less than the first predetermined amount. The detection circuit is configured to detect whether the USB port () of the biosensor meter () is connected to the USB port () of another electronic device, such as a computer (), and to prompt the meter's user for not carrying out a measurement in order to reduce the risk of electrical shock. 1. A biosensor meter for determining an analyte concentration in a fluid , the biosensor meter comprising:a USB port comprising a first data signal port terminal;a detection circuit comprising a first input terminal coupled to the first data signal port terminal, and comprising an output terminal,wherein the detection circuit is adapted to provide at the output terminal a first output signal when a current sensed at the first input terminal is greater than or equal to a first predetermined amount, and a second output signal when the current sensed at the first input terminal is less than the first predetermined amount.2. The biosensor meter of claim 1 , wherein the detection circuit comprises an operational amplifier comprising an inverting input coupled to first input terminal claim 1 , and a non-inverting input coupled to a voltage reference.3. The biosensor meter of claim 2 , wherein the detection circuit further comprises a feedback resistor coupled between the inverting input and ...

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Номер записи: 62
09-06-2016 дата публикации

SCALABLE AND HIGH THROUGHPUT BIOSENSING PLATFORM

Номер: US20160161466A1
Автор: Kuan Germano José António Henriques, Piedade Moisés Simões
Принадлежит:

A multi-channel high performance embedded system is provided, which is capable of high throughput biological analysis. A configurable acquisition and processing architecture combines dedicated co-processors to perform signal filtering and other computational demanding tasks, with a central processor controlling the whole system. The mapping of the architecture into an architecture, such as the Zynq SoC, demonstrates the ability of the biosensing platform to support a significant number of sensors, while ensuring a high sampling frequency. Furthermore, the Zynq reconfiguration abilities provide a mechanism to adapt the processing and maximize the biological sensitivity. 1. A biological detection system comprising:a biochip having at least two blocks of sensors, each block of sensors having a signal acquisition channel that is independently accessible such that each block of sensors can be read in parallel; and drive circuitry to drive each block of sensors of the biochip;', 'a set of acquisition interfaces arranged such that a select one acquisition interface is coupled to a corresponding one signal acquisition channel;', 'a set of co-processors such that a select co-processor is uniquely associated with a corresponding one of the acquisition interfaces; and', 'a central processor that controls the drive circuitry, interfaces with the set of acquisition interfaces and interfaces with the set of co-processors, to read data from the biochip., 'a biosensing platform having216. The biological detection system of claim 1 , wherein said each block of sensors having an array of at least sensors and a corresponding time division multiplexer to read out individual sensors from a corresponding block.3. The biological detection system of claim 1 , wherein the set of acquisition interfaces further comprises an analog to digital converter and a controller claim 1 , where the controller conveys information from the analog to digital converter to its corresponding co-processor.4. ...

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Номер записи: 63
07-06-2018 дата публикации

Self correction for spatial orientation and motion of portable clinical analyzers

Номер: US20180157785A1
Автор: Gary Vandersleen, Graham Davis, Narendra Soman, Paul Wasserman, PIERRE Emeric
Принадлежит: ABBOTT POINT OF CARE INC

The present invention covers the integration and utility of accelerometer features into a clinical analysis system. For example, measurement of dynamic acceleration and orientation of a blood-testing instrument with respect to Earth's gravitational field may be used to determine reliability of a test procedure and optionally to provide corrective elements thereof.

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Номер записи: 64
08-06-2017 дата публикации

CHARGING DEVICE FOR BIOLOGICAL INFORMATION MEASUREMENT DEVICE AND BIOLOGICAL INFORMATION MEASUREMENT DEVICE CHARGED USING SAME

Номер: US20170160260A1
Автор: FURUKAWA Tatsuhiko
Принадлежит:

Certain implementations have a main body case having a contact face of a biological information measurement device on its surface, and a first non-contact charging portion composed of a charging coil disposed opposite the contact face with the biological information measurement device inside the main body case. In addition, some may have a controller that is connected to the first non-contact charging portion, and a display section that is connected to the controller. Upon completion of the charging of the biological information measurement device via the first non-contact charging portion, the controller connected to the display section may display on the display section that the biological information measurement device will be incapable of measurement for a specific length of time. 1. A biological information measurement device that is charged by a charging device for the biological information measurement device , the biological information measurement device comprising:a main body case including a sensor mounting portion;a measurement section connected to the sensor mounting portion, the measurement section disposed inside the main body case;a charging portion;a rechargeable battery;a display section; anda controller connected to the measurement section and the display section,the controller configured to calculate a measurement-impossible time, during which it is incapable of measurement for a specific length of time after the end of charging.25-. (canceled)6. The biological information measurement device according to claim 1 , wherein:the controller configured to display the measurement-impossible time on the display section.7. The biological information measurement device according to claim 1 , further comprising:a clock connected to the controller; anda memory section configured to store the measurement-impossible time;wherein the controller determine whether the measurement-impossible time has elapsed by using the clock.8. The biological information ...

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Номер записи: 65
15-06-2017 дата публикации

SPECIMEN ANALYSIS APPARATUS AND METHOD OF ANALYZING SPECIMEN USING THE SAME

Номер: US20170167985A1
Автор: KIM Chung Ung, LEE Beom Seok, Lee Sang Hyun, Park Sung Ha, Song Kyung-mi
Принадлежит:

Disclosed herein are specimen analysis apparatus and method of analyzing specimen using the same. The specimen analysis apparatus includes a cartridge configured to accommodate at least three pH indicators having different properties and an analyzer configured to determine whether a specimen is acidic or basic using one of the pH indicators. The analyzer determines a pH measurement value using another pH indicator selected based on whether the specimen is acidic or basic. 1. A specimen analysis apparatus comprising:a cartridge configured to accommodate at least three pH indicators having different properties; andan analyzer configured to:determine whether a specimen is acidic or basic using a pH indicators from the at least three pH indicators; anddetermine a pH measurement value using another pH indicator from the at least three pH indicators selected based on the determination that the specimen is acidic or basic.2. The specimen analysis apparatus according to claim 1 , wherein the at least three pH indicators have different color change ranges.3. The specimen analysis apparatus according to claim 1 , wherein the pH indicator used to determine whether the specimen is acidic or basic has a widest color change range among the at least three pH indicators claim 1 , and the another pH indicator used to determine the pH measurement value is selected from at least two pH indicators having different color change ranges based on the determination that the specimen is acidic or basic.4. The specimen analysis apparatus according to claim 1 , further comprising a controller configured to:generate a user interface configured to provide analysis information about a target analyte in the specimen and information about whether a pH measurement value of the target analyte in the specimen is in a normal range; anddisplay the user interface on a display.5. The specimen analysis apparatus according to claim 1 , wherein the at least three pH indicators comprises a universal pH ...

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Номер записи: 66
23-06-2016 дата публикации

SENSOR HEAD FOR USE WITH IMPLANTABLE DEVICES

Номер: US20160178558A1
Автор: Brauker James H., Rhodes Rathbun K., Shults Mark C., Tapsak Mark A.
Принадлежит:

The present invention provides a sensor head for use in an implantable device that measures the concentration of an analyte in a biological fluid which includes: a non-conductive body; a working electrode, a reference electrode and a counter electrode, wherein the electrodes pass through the non-conductive body forming an electrochemically reactive surface at one location on the body and forming an electronic connection at another location on the body, further wherein the electrochemically reactive surface of the counter electrode is greater than the surface area of the working electrode; and a multi-region membrane affixed to the nonconductive body and covering the working electrode, reference electrode and counter electrode. In addition, the present invention provides an implantable device including at least one of the sensor heads of the invention and methods of monitoring glucose levels in a host utilizing the implantable device of the invention. 1. A sensor for use in a glucose measuring device , the sensor comprising:a first electrode, a second electrode, and a non-conductive body located between the first electrode and the second electrode, wherein the first electrode and the second electrode each form an electrochemically reactive surface at one end of the sensor and an electronic connection at another end of the sensor; anda multi-region membrane covering the first electrode and the second electrode, wherein the multi-region membrane comprises an immobilized enzyme domain comprising an enzyme in at least a portion thereof, wherein the multi-region membrane comprises a glucose exclusion domain that is permeable to oxygen and interferes with glucose transport across said membrane, and wherein said glucose exclusion domain does not cover the working electrode.2. The sensor of claim 1 , wherein the multi-region membrane further comprises an interference domain more proximal to said electrochemically reactive surfaces than said glucose exclusion domain.3. The ...

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Номер записи: 67
21-06-2018 дата публикации

Verifying Operation of a Meter

Номер: US20180172618A1
Автор: Baskeyfield Damian, Blythe Stephen
Принадлежит:

A method of verifying operation of a meter for reading electrochemical test devices, includes obtaining a reference output signal indicative of a response generated at an electrochemical test device when the electrochemical test device reacts with a reference test fluid; applying with the meter an algorithm to the reference output signal so as to obtain a reference test result, wherein the algorithm is for use in estimating an unknown concentration of an analyte in a sample of the reference test fluid; and determining whether the reference test result is valid so as to verify operation of the meter. 1. A method of verifying operation of a meter for reading electrochemical test devices , comprising:obtaining a reference output signal indicative of a response generated at an electrochemical test device when the electrochemical test device reacts with a reference test fluid;applying with the meter an algorithm to the reference output signal so as to obtain a reference test result, wherein the algorithm is for use in estimating an unknown concentration of an analyte in a sample of the reference test fluid; anddetermining whether the reference test result is valid so as to verify operation of the meter.2. The method of claim 1 , further comprising storing the reference output signal in a memory of the meter.3. The method of claim 1 , further comprising identifying an anomaly in the reference output signal in response to determining the reference test result is not valid.4. The method of claim 1 , further comprising identifying an error in the algorithm in response to determining the reference test result is not valid.5. The method of claim 1 , further comprising determining a corruption of a memory of the meter claim 1 , the memory storing the reference output signal and/or the algorithm.6. The method of claim 1 , wherein the sample of the reference test fluid is: blood claim 1 , plasma claim 1 , urine claim 1 , saliva claim 1 , lacrimal fluid claim 1 , sweat claim 1 , ...

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Номер записи: 68
21-06-2018 дата публикации

A MEMS THROMBELASTOGRAPH/VISCOELASTICITY ANALYZER

Номер: US20180172663A1
Автор: QIN Qi
Принадлежит: ATANTARES CORP.

Disclosed herein is a micro thrombelastograph micro TEG which can be used in clinic, research and POC (point of care) settings. The present disclosure relates to a miniaturization method of traditional thrombelastograph assay based on the micro electro-mechanical system (MEMS) technology platform. In addition, this disclosure can be applied to general viscosity/rheology measurement. 1. A rotational viscosity/viscoelasticity measurement instrument design and its fabrication process as shown and described herein. This patent application claims priority to and the benefit of United States provisional patent application serial number U.S. Ser. No. 62/175,610, entitled “MEMS Thrombelastograph/Viscoelasticity Analyzer”, filed on Jun. 15, 2015, the entire contents of which are herein incorporated by reference.Thromboelastometry (TEM), previously named rotational thromboelastography (ROTEG) or rotational thromboelastometry (ROTEM), is an established viscoelastic method for hemostasis testing in whole blood. It is modification of traditional thromboelastography (TEG). TEM investigates the interaction of coagulation factors, their inhibitors, anticoagulant drugs, blood cells, specifically platelets, during clotting and subsequent fibrinolysis. The rheological conditions mimic the sluggish flow of blood in veins. TEM is performed with the ROTEM whole blood analyzer (Tem Innovations GmbH, Munich) and is an enhancement of thrombelastography, originally described by Hartert in 1948.The subject invention comprises a method and apparatus to make miniaturized/portable and robust instruments for thromboelastometry. The invention uses MEMS technology to integrate rotation driver, position/force sensor and sensing pole in a single embodiment. This device is made by silicon fabrication technology and can be as small as several millimeters. The device is operated totally electrically. Thus it can be very compact and good for POC application. In addition, its natural frequency can be far ...

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Номер записи: 69
08-07-2021 дата публикации

Biosignal measuring and stimulating device having bioelectrode

Номер: US20210204855A1
Автор: Heon-Jin Choi, Jae-Suk Sung, Ju Kwan NA, Youngcheol Chae
Принадлежит: University Industry Foundation UIF of Yonsei University

The present invention provides a biosignal measuring and stimulating device having bioelectrodes in which a signal measurement unit (200) including bioelectrodes composed of a plurality of microelectrodes (210) is disposed on a substrate (100), wherein the signal measurement unit (200), a measured signal processing unit (300), and at least one of a driving power unit (400) and a wireless communication unit (500) are disposed on the substrate (100) in a vertical or lateral direction, and the biosignal measuring and stimulating device measures biosignals or stimulates from the microelectrodes formed in an array pattern.

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Номер записи: 70
05-07-2018 дата публикации

A biochemical analytical technique

Номер: US20180185838A1
Автор: Hans-Georg Zimmermann, Mark Matzas, Peter Paulicka, Ralph Grothmann, Stefanie Vogl, Walter Gumbrecht
Принадлежит: SIEMENS AG

A biochemical analytical device and a biochemical analytical method for determining an analyte in a test sample are provided. In the technique, the biochemical analytical device includes a sample port to receive the test sample, a sensor to probe the test sample and to generate sensor data, and a processor. The sensor data corresponds to the analyte in the test sample. The processor receives the sensor data from the sensor and selects a non-linear function for the received sensor data. The processor fits the selected non-linear function to the sensor data. Additionally, the processor compares the fitted non-linear function to a reference data to determine the analyte in the test sample.

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Номер записи: 71
06-07-2017 дата публикации

MEASUREMENT ERROR CORRECTION DEVICE OF BIO-MEASURER

Номер: US20170188915A1
Автор: Cha Geun Sig, Kim Jin Ho, KIM Tae Eun, NAM Hak hyun, PARK Hyo Seon
Принадлежит: I-SENS, INC.

The present invention relates to a measurement error correction device of a bio-measurer and, more specifically, provides a measurement correction device which: enables a device for measuring a measurement error to be arranged inside a bio-measurer such that a measurement error can be corrected after the bio-measurer is manufactured; and enables a user to directly confirm, automatically or by the user's selection, whether the bio-measurer is normally operated at an early stage of the operation of the bio-measurer, thereby reducing the time and the cost for correcting a measurement error during a manufacturing process of the bio-measurer. 1. A measurement error correction device of a bio-measurer , the device comprising:a first simulator having a first resistance value;a second simulator having a second resistance value;a measurement section measuring a first current value by applying electric power to the first simulator and measuring a second current value by applying electric power to the second simulator; anda correction section correcting a measurement error of the bio-measurer using the first current value and the second current value.2. The measurement error correction device according to claim 1 , wherein the correction section corrects the measurement error of the bio-measurer by measuring the first current value and the second current value in an error correction mode in which an error of the bio-measurer is corrected.3. The measurement error correction device according to claim 2 , wherein the correction section calculates a correction slope and a correction size from the measured first current value claim 2 , the measured second current value claim 2 , a first theoretical current value corresponding to the first resistance value and applied electric power claim 2 , and a second theoretical current value corresponding to the second resistance value and applied electric power.4. The measurement error correction device according to claim 3 , further ...

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Номер записи: 72
20-06-2019 дата публикации

Mind-altering substance testing system

Номер: US20190183418A1
Автор: James John BROWN, Roger Alan HUNT
Принадлежит: ALCOLIZER PTY Ltd

The present invention relates to a mind-altering substance testing unit. The unit includes a display module for displaying an indication of a drug or alcohol. A sensor module is releasably fastened to the display module and includes sensors for sensing the drug and alcohol. The unit also includes a sample cartridge for receiving a sample and for releasably fastening to the sensor module so that the sensor module can sense the drug. Advantageously, the same testing unit can be used to sense alcohol and the drug avoiding the need for separate testing units.

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Номер записи: 73
06-07-2017 дата публикации

REFERENCE ELECTRODE

Номер: US20170191960A1
Автор: ARIMOTO Kimihiko, KOMADA Yoshito, MINOWA Hiroki, Miyamura Kazuhiro, Mori Yoshihiro, Nakai Yoko, SEKO Tomoko, Tsujioka Yuiji
Принадлежит:

A reference electrode according to the present invention maintains continuity between an internal solution and measurement sample and measures the electrical potential of the measurement sample even if the measurement sample in a liquid junction of the reference electrode has air bubbles mixed therein. This reference electrode is provided with: a second body provided with a second internal solution chamber in which a second internal solution is housed and a liquid junction portion disposed in the second internal solution chamber such that the second internal solution and measurement sample that is to be measured come into contact; and an internal electrode disposed inside the second internal solution. The liquid junction portion is formed from a conduction component formed from a porous or fibrous component and an aperture adjacent to the conduction component. 1. A reference electrode comprising:a body having an internal solution chamber that holds an internal solution, and a liquid junction portion that is disposed in the internal solution chamber such that the internal solution and a measurement sample that is to be measured are in mutual contact; andan internal electrode that is disposed inside the internal solution chamber, whereinthe liquid junction portion is formed by a conduction component that is formed by a porous or fibrous component, and an aperture that is adjacent to the conduction component.2. The reference electrode according to claim 1 , wherein the conduction component is positioned such that the size of the aperture is larger than the size of minute holes formed in the conduction component.3. The reference electrode according to claim 1 , wherein an end portion of the conduction component that is in contact with the measurement sample is disposed such that this end portion is substantially flush with the aperture claim 1 , or such that this end portion protrudes onto the measurement sample side beyond the aperture.4. The reference electrode ...

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Номер записи: 74
12-07-2018 дата публикации

YARN, DETECTION SYSTEM, FIBER SHEET, CONNECTOR, DETECTION DEVICE, AND LIQUID TYPE ESTIMATION METHOD

Номер: US20180195985A1
Автор: NEBUYA Satoru
Принадлежит:

A yarn has a first conductive yarn having conductivity, a first insulating section covering the first conductive yarn and formed of an insulating material having absorbency, and a second conductive yarn having conductivity and disposed on an outer circumferential side of the first insulating section. 1. A yarn comprising:a first conductive yarn having conductivity;a first insulating section covering the first conductive yarn and formed of an insulating material having absorbency; anda second conductive yarn having conductivity and disposed on an outer circumferential side of the first insulating section.2. The yarn according to claim 1 , wherein the second conductive yarn is wound on an outer circumferential surface of the first insulating section in a spiral shape.3. The yarn according to claim 1 , wherein the second conductive yarn is coated with a second insulating section formed of an insulating material having absorbency.4. The yarn according to claim 1 , wherein the yarn is coated with a third insulating section formed of an insulating material having absorbency.5. The yarn according to claim 1 , wherein the insulating material is cotton.6. A detection system claim 1 , comprising:a fiber sheet; anda detection device,wherein the fiber sheet comprises:a fiber sheet main body formed of an insulating material; anda sensor fiber including at least two conductive bodies that are combined such that they do not come in contact with each other,wherein the sensor fiber comprises:a first conductive yarn having conductivity;an insulating section covering the first conductive yarn and formed of an insulating material having absorbency; anda second conductive yarn having conductivity and disposed on an outer circumferential side of the insulating section, andwherein the detection device comprises:an alternating current signal output unit configured to input an alternating current signal to between the at least two conductive bodies formed on the fiber sheet;a frequency ...

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Номер записи: 75
13-07-2017 дата публикации

DETECTION DEVICE, DETECTION SYSTEM, DETECTION METHOD, AND PROGRAM

Номер: US20170199143A1
Автор: NEBUYA Satoru
Принадлежит: SCHOOL JURIDICAL PERSON KITASATO INSTITUTE

A detection device includes: a frequency property acquisition unit that acquires a frequency property when an alternating-current signal is input to at least two conductive bodies provided on a fiber sheet; and a detection signal output unit that outputs a detection signal when the frequency property acquisition unit acquires a predetermined frequency property. 1. A detection device comprising:a frequency property acquisition unit that acquires a frequency property when an alternating-current signal is input to at least two conductive bodies provided on a fiber sheet; anda detection signal output unit that outputs a detection signal when the frequency property acquisition unit acquires at least one of a frequency property that indicates a predetermined difference according to a frequency difference between the alternating-current signals input to the conductive bodies and a frequency property that indicates a predetermined change according to a time elapse.2. The detection device according to claim 1 , whereinthe frequency property acquisition unit acquires a frequency property when each of an alternating-current signal in a first frequency and an alternating-current signal in a second frequency is input to the at least two conductive bodies, andthe detection signal output unit outputs the detection signal when a difference between a frequency property when the alternating-current signal in the first frequency is input to the conductive bodies and a frequency property when the alternating-current signal in the second frequency is input to the conductive bodies is a predetermined difference.3. A detection system comprising:a fiber sheet; and a detection device, whereinat least two conductive bodies are provided on the fiber sheet, and a frequency property acquisition unit that acquires a frequency property when an alternating-current signal is input to at least two conductive bodies provided on the fiber sheet; and', 'a detection signal output unit that outputs a ...

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Номер записи: 76
14-07-2016 дата публикации

WATERTIGHT CASING WITH INTEGRATED ELECTRICAL CONTACTS

Номер: US20160205798A1
Автор: Allan FAULKNER, David ELDER, Eamon GUINAN, Jonathan NELSON, Malcolm HAMER, Ryan MAGENNIS
Принадлежит:

A watertight casing for an electronic device includes an electrically-insulating plastic case (EIPC) and at least one electrically-conductive thermoplastic elastomer (ECTPE) contact. The EIPC includes inwardly and outwardly facing surfaces. The ECTPE contact that includes a proximal contact portion with a proximal contact surface, a distal contact portion with a distal contact surface, and a channel portion connecting the proximal contact portion and the distal contact portion. The ECTPE contact(s) is integrated with the EIPC such that the ECTPE contact(s) extends through the EIPC from the outwardly facing surface to the inwardly facing surface and such that the proximal contact surface is disposed in proximity to the inwardly facing surface and the distal contact surface is disposed in proximity to the outwardly facing surface. The ECTPE contact(s) is adhered to the EIPC such that a watertight seal between the outwardly facing surface and the inwardly facing surface is present therebetween. 121.-. (canceled)22. A watertight casing for an electronic device , the watertight casing comprising: an inwardly facing surface; and', 'an outwardly facing surface;, 'an electrically-insulating plastic case with a proximal contact portion with a proximal contact surface;', 'a distal contact portion with a distal contact surface, and', 'a channel portion connecting the proximal contact portion and the distal contact portion,, 'at least one electrically-conductive thermoplastic elastomer (ECTPE) contact that includeswherein the at least one ECTPE contact is integrated with the electrically-insulating plastic case such that the ECTPE contact extends through the electrically-insulating plastic case from the outwardly facing surface to the inwardly facing surface; andwherein the proximal contact surface is disposed in proximity to the inwardly facing surface and the distal contact surface is disposed in proximity to the outwardly facing surface; andwherein the at least one ECTPE ...

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Номер записи: 77
21-07-2016 дата публикации

CMOS COMPATIBLE BIOFET

Номер: US20160209355A1
Автор: Chang Che-Ming, CHOU Chung-Yen, HSIEH Yuan-Chih, Tseng Lee-Chuan
Принадлежит:

The present disclosure relates to an integrated chip having an integrated bio-sensor with a sensing well having one or more sensing well spacers that reduce a size of the sensing well after its formation. In some embodiments, the integrated bio-sensor has a sensing device disposed within a semiconductor substrate. A dielectric structure is disposed onto a first side of the semiconductor substrate. The dielectric structure has an opening with a first width, which is exposed to an ambient environment and that overlies the sensing device. One or more sensing well spacers are arranged on sidewalls of the opening. The one or more sensing well spacers expose a bottom surface of the opening to define a sensing well having a second width that is smaller than the first width. 1. An integrated chip having an integrated bio-sensor , comprising:a sensing device disposed within a semiconductor substrate;a dielectric structure disposed onto a first side of the semiconductor substrate and having an opening that is exposed to an ambient environment and that overlies the sensing device, wherein the opening has a first width; andone or more sensing well spacers arranged on sidewalls of the opening, wherein the one or more sensing well spacers expose a bottom surface of the opening to define a sensing well having a second width that is smaller than the first width.2. The integrated chip of claim 1 , further comprising:a high-k dielectric layer disposed within the sensing well at a position that is laterally between the one or more sensing well spacers and the dielectric structure, and that is vertically between the one or more sensing well spacers and the sensing device.3. The integrated chip of claim 2 , wherein the high-k dielectric layer further abuts a top surface of the dielectric structure that opposes the semiconductor substrate.4. The integrated chip of claim 2 , wherein the one or more sensing well spacers comprise a material that etches at a faster etching rate than the high ...

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Номер записи: 78
20-07-2017 дата публикации

LIGHT SWITCHING INDICATORS BY WAVELENGTH FILTRATION

Номер: US20170205553A1
Автор: Prais Eugene Randal
Принадлежит:

A testing system configured to determine an analyte concentration has a user interface that includes a number of visual indicators on its exterior housing. The visual indicators convey different types of information to a user of the testing system when illuminated. Additionally, the indicators are independent of one another in that they can each be illuminated in different colors from one other and turn on and/or off independently of one another. Further, the visual indicators are illuminated using a common lighting element (e.g., a single light emitting diode (“LED”)) in combination with one or more waveguides and one or more filters located inside the testing system. 1. A testing system adapted to determine a concentration of an analyte , the testing system comprising:a user interface including a plurality of visual indicators;a lighting element operative to emit light of a plurality of wavelengths corresponding to a plurality of colors;a light guide coupled to the lighting element and configured to transmit light emitted by the lighting element;a first filter coupled to a first one of the plurality of visual indicators, the first filter configured to filter light of a first wavelength being transmitted by the light guide; anda second filter coupled to a second one of the plurality of visual indicators, the second filter configured to filter light of the first wavelength being transmitted by the light guide.2. The testing system of claim 1 , wherein the first filter is configured to transmit light of the first wavelength and the second filter is configured to attenuate light of the first wavelength.3. The testing system of claim 1 , wherein the lighting element comprises a plurality of light-emitting diodes.4. The testing system of claim 1 , wherein the lighting element consists of a single light-emitting diode.5. The testing system of claim 1 , wherein a second one of the plurality of visual indicators is coupled to a sensor port housing.6. The testing system of ...

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Номер записи: 79
19-07-2018 дата публикации

Analyte Measurement Devices and Systems, and Components and Methods Related Thereto

Номер: US20180202962A1
Автор: Bulala Cherie, Myles Christopher, Simmons Matthew, Song Bonita Park
Принадлежит: ABBOTT DIABETES CARE INC.

A modular analyte measurement system having a replaceable strip port module is provided to permit contaminated modules to be replaced. Some aspects of the present disclosure related to barriers for strip ports or the sealing of strip ports and/or analyte measurement devices to maintain a clean strip port and/or enable the strip port to be cleaned for reuse. Cleaning tools are also provided. Also provided are strip port interfaces that guide fluid away from the strip port opening, as well as absorptive elements that prevent fluid from entering a strip port. Analyte measurement devices with gravity sensors or accelerometers are also provided, along with methods related thereto. Also provided are docking station that serve as an information server and provides storage and recharging capabilities. 1. A method of using an analyte measurement system , the method comprising: wherein disposed within the receptacle of the meter housing of the analyte meter are electrical connections and the first replaceable strip port module comprises:', 'a module housing having a test strip aperture and an interface aperture;', 'an analyte test strip port; and', 'wherein the electrically coupling results when the electrical contacts of the first replaceable strip port module electrically mate with the electrical connections of the analyte meter;', 'an electrical interface having a plurality of electrical contacts coupled to the analyte test strip port that electrically mate to the analyte meter through the interface aperture of the module housing,'}], 'electrically coupling and positioning a first replaceable strip port module into a receptacle of a meter housing of an analyte meter,'}receiving an analyte test strip having an analyte sample into the test strip aperture;analyzing the analyte; andelectrically de-coupling and removing the first replaceable strip port module from the receptacle of the meter housing of the analyte meter.2. The method of claim 1 , wherein electrically coupling ...

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Номер записи: 80
26-07-2018 дата публикации

AUTOMATIC QUALITY CONTROL DEVICE OF BLOOD CELL ANALYZER

Номер: US20180209999A1
Автор: Han Kyung Ja
Принадлежит:

Provided is a technique for automatically performing quality control of a blood cell analyzer so as to minimize waste of time and manpower and quality control errors through automation of everyday repetitive quality control tasks. According to an embodiment of the present invention, an automatic quality control device of a blood cell analyzer includes: a reagent storage unit installed on the blood cell analyzer and configured to refrigerate and store at least one reagent for use in quality control of the blood cell analyzer; a transfer device installed between the reagent storage unit and a blood cell test unit of the blood cell analyzer for moving the at least one reagent from the reagent storage unit to the blood cell test unit of the blood cell analyzer; and a quality control controller configured to control an operation of the transfer device, receive from the blood cell test unit information about results of a quality control test performed using the at least one reagent to determine whether the quality control test is passed, and output information about results of the determination whether the quality control test is passed through an output device of the blood cell analyzer. 1. An automatic quality control device of a blood cell analyzer , the automatic quality control device comprising:a reagent storage unit installed on the blood cell analyzer and configured to refrigerate and store at least one reagent for use in quality control of the blood cell analyzer;a transfer device installed between the reagent storage unit and a blood cell test unit of the blood cell analyzer for transferring the at least one reagent from the reagent storage unit to the blood cell test unit of the blood cell analyzer; anda quality control controller configured to control an operation of the transfer device, receive from the blood cell test unit information about results of a quality control test performed using the at least one reagent to determine whether the quality control ...

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Номер записи: 81
04-07-2019 дата публикации

Mobile hand-held device with reusable biosensor cartridge

Номер: US20190204260A1
Автор: Mehmet Yagmur GÖK, Serkan BARUT, Veysi CANSU, YiIdiz ULUDAG
Принадлежит: Scientific and Technological Research Council of Turkey TUBITAK

This invention relates to a handheld mobile device which can analyze and measure whole blood, serum, urine or analytes which contain target agents such as mycotoxin, aflatoxin or cholera etc. with a easy to use reusable cartridge consisting of a cartridge head and cartridge body. The cartridge comprises four syringes, one of which being detachable. A waste reservoir is integrated with the syringes.

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Номер записи: 82
12-08-2021 дата публикации

Multiple times available drug concentration measuring apparatus and method

Номер: US20210245154A1
Автор: Kun Nyun Kim, Min Ji JEON, Mun Bae JEON, Yeon Hwa Kwak
Принадлежит: KOREA ELECTRONICS TECHNOLOGY INSTITUTE

Disclosed is A multiple times available drug concentration measuring apparatus including a sample input unit configured to allow a liquid drug sample to be introduced therethrough, a dilution unit configured to add a solvent to a portion of the liquid drug sample in order to dilute the liquid drug sample, a concentration measurement unit configured to measure the concentration of the liquid drug sample using a sensor, and a control unit configured to decide a dilution ratio of the liquid drug sample based on data received from the concentration measurement unit, to perform control such that the dilution unit dilutes the liquid drug sample according to the dilution ratio, and to calculate the concentration of the liquid drug sample based on the dilution ratio and the data received from the concentration measurement unit.

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Номер записи: 83
12-08-2021 дата публикации

DETECTION OF AN ANALYTE USING MULTIPLE ELEMENTS THAT CAN TRANSMIT OR RECEIVE

Номер: US20210247379A1
Автор: Bosua Phillip
Принадлежит:

A method of detection of an analyte includes using a detector array having at least two detector elements that can emit electromagnetic waves, and selectively connecting a transmit circuit to any one or more of the at least two detector elements of the detector array. At least one transmit signal is generated using the transmit circuit, where the at least one transmit signal is in a radio or microwave frequency or visible range of the electromagnetic spectrum. The at least one transmit signal is transmitted into a target containing at least one analyte of interest using the one or more of the at least two detector elements connected to the transmit circuit. A receive circuit is selectively connected to a different one or more of the at least two detector elements of the detector array, and the receive circuit and the different one or more of the at least two detector elements of the detector array are used to detect a response resulting from transmission of the at least one transmit signal into the target containing the at least one analyte of interest. 1. A method of detection of an analyte , comprising:in a detector array having at least two detector elements that can emit electromagnetic waves, selectively connecting a transmit circuit to any one or more of the at least two detector elements of the detector array;generating at least one transmit signal using the transmit circuit, the at least one transmit signal is in a radio or microwave frequency or visible range of the electromagnetic spectrum;transmitting the at least one transmit signal into a target containing at least one analyte of interest using the one or more of the at least two detector elements connected to the transmit circuit;selectively connecting a receive circuit to a different one or more of the at least two detector elements of the detector array;using the receive circuit and the different one or more of the at least two detector elements of the detector array to detect a response resulting ...

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Номер записи: 84
18-08-2016 дата публикации

COMMUNICATION INTERFACE CLIP FOR A HANDHELD MEDICAL DEVICE

Номер: US20160238588A1
Автор: Sams Howard, Staubert Andreas
Принадлежит:

A communication interface apparatus is provided for use with a handheld medical test device. The communication interface apparatus is comprised of an attachment member configured to detachably couple to a housing of the medical test device, where the attachment member substantially overlays a rear side of the medical test device. The communication interface apparatus houses an infrared receiver, a secondary transceiver and a controller. The infrared receiver is arranged such that its input port aligns with an output port of an infrared transmitter in the medical test device when the attachment member is coupled to the medical test device. 1. A communication interface apparatus for use with a handheld medical test device having an infrared transmitter , comprising:an attachment member providing an enclosure and configured to detachably couple to a housing of the medical test device, where the attachment member substantially overlays a rear side of the medical test device;an infrared receiver residing in the enclosure and configured to receive data wirelessly in accordance with a first communication protocol from the infrared transmitter of the medical test device, where an input port of the infrared receiver aligns with an output port of the infrared transmitter in the medical test device when the attachment member is coupled to the medical test device;a secondary transceiver residing in the enclosure and configured to transmit data wirelessly in accordance with a second communication protocol, where the first communication protocol differs from the second communication protocol;a controller residing in the enclosure and that operates in a low power mode, wherein the controller is configured to periodically transition from the low power mode to a normal mode, and interacts with the infrared receiver in the normal mode to receive data from the medical test device, where the communication interface apparatus consumes more electric power in the normal mode than the low ...

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Номер записи: 85
18-08-2016 дата публикации

REVERSE BATTERY PROTECTION FOR BATTERY-POWERED DEVICES

Номер: US20160241015A1
Автор: Gofman Igor
Принадлежит:

Reverse battery protection circuits for devices powered by batteries coupled in parallel can include both P-channel and N-channel MOSFETs. Each positive battery terminal connector of a battery-powered device can be coupled to a gate of an N-channel MOSFET or to both a gate of an N-channel MOSFET and a gate of a P-channel MOSFET. In some embodiments, each negative battery terminal connector of the device can be connected to a gate of a P-channel MOSFET. In the event of a reverse battery connection, one or more of the protection circuit's P-channel and N-channel MOSFETS can switch to a non-conductive state to isolate the device's load from an incorrectly installed battery and prevent the incorrectly installed battery and/or other parallel-coupled battery from prematurely discharging. Methods of protecting a load from a reverse battery connection are also provided, as are other aspects. 1. A reverse battery protection circuit comprising:a first load terminal;a second load terminal;a first P-channel MOSFET having a drain, a gate, and a source coupled to the first load terminal;a first N-channel MOSFET having a drain, a gate, and a source coupled to the second load terminal;a first positive battery terminal connector coupled to the drain of the first P-channel MOSFET and to the gate of the first N-channel MOSFET, the first positive battery terminal connector configured to electrically connect to a first battery terminal; anda first negative battery terminal connector coupled to the drain of the first N-channel MOSFET and to the gate of the first P-channel MOSFET, the first negative battery terminal connector configured to electrically connect to a second battery terminal.2. The reverse battery protection circuit of wherein the first positive battery terminal connector has a top contact configuration.3. The reverse battery protection circuit of further comprising:a first resistive element coupled in series between the first positive battery terminal connector and the gate ...

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Номер записи: 86
24-08-2017 дата публикации

REACTANCE AND CAPACITANCE SENSING PLATFORM FOR DETECTING MICROORGANISMS

Номер: US20170240855A1
Автор: Beaty Patrick Shawn, Brasch Michael A., Hosmane Suneil, Polley David, Rosales Julie L., Smith Kerry Lynn
Принадлежит: BECTON, DICKINSON AND COMPANY

A system and method with increased sensitivity to microorganism growth. The system includes signal processing electronic circuit connected to a consumable or vessel through two or more electrodes that fully penetrate the vessel and are in contact with the fluid contents. The electronic circuit is configured to detect a component of the total impedance of the sample, specifically the “out-of-phase” or imaginary reactance component, which has a sensitive response to organism growth in a frequency-dependent manner. The system detects changes in both the composition of charged molecules in the liquid matrix and the number of microorganisms based on monitoring the sample for change in this parameter. This results in a 5-70% reduction in time-to-detection (TTD). The system and method detect organisms in a plurality of vessel shapes, volumes, and matrix (or media) formats. The electrodes are fully immersed in a continuous body of liquid sample. The distance between electrodes may be adjusted or tuned to fit the needs of the vessel. The voltage inputs can also be adjusted to allow proper detection of the contents within the vessel. 1. An impedance-based method for detecting microbial growth , the method comprising:providing a vessel with at least two electrodes disposed therein;introducing a sample to be monitored for microbial growth in the vessel, wherein the electrodes are immersed in the sample;measuring total impedance of the sample to determine the total ionic composition of the medium over time;from the measurement, determining the imaginary reactance component of the total impedance over time;from the determination of the imaginary reactance over time, determining whether microorganism growth has occurred.2. The impedance-based method of further comprising tuning the frequency sensitivity of the system.3. The impedance-based method of wherein the tuning is by adjusting a resistance of one or more resistors in parallel with a capacitive input stage of a lock-in ...

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Номер записи: 87
23-08-2018 дата публикации

OPERATION AND VERIFICATION OF A PORTABLE CLINICAL ANALYSIS SYSTEM

Номер: US20180238854A1
Автор: Davis Graham, Emeric Pierre, Fetters Christopher, Soman Narendra, Vandersleen Gary, Wasserman Paul
Принадлежит: ABBOTT POINT OF CARE INC.

The present invention covers the integration and utility of accelerometer features into a clinical analysis system. For example, measurement of dynamic acceleration and orientation of a blood-testing instrument with respect to Earth's gravitational field may be used to determine reliability of a test procedure and optionally to provide corrective elements thereof. 1. A portable clinical system for in vitro analysis , the system comprising:a test device configured to perform an in vitro analytical test; and a port configured to receive the test device and', determine spatial orientation and motion of the analyzer during a test cycle of the test device,', 'generate a test cycle profile for the test cycle, wherein the generated test cycle profile indicates the determined spatial orientation and motion of the analyzer during the test cycle,', 'compare the generated test cycle profile to a pre-established profile for the test device,', 'determine whether the generated test cycle profile deviates from the pre-established profile, and', 'at least one of (i) provide an alert prompting a user of the system to take corrective action and (ii) perform system maintenance, when the test cycle profile deviates from the pre-established profile., 'a computing device configured to], 'an analyzer comprising'}2. The system of claim 1 , wherein the computing device is further configured to determine whether the system maintenance fails and to communicate the failure of the system maintenance to an electronic auditable system.3. The system of claim 1 , wherein the computing device is further configured claim 1 , when the generated test cycle profile deviates from the pre-established profile claim 1 , to prevent reporting of a test result obtained from performance of the in vitro analytical test claim 1 , and to provide an alert prompting the user of the system that the system maintenance is required.4. The system of claim 3 , wherein the computing device is further configured to ...

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Номер записи: 88
24-08-2017 дата публикации

Analyte Measurement Devices and Systems, and Components and Methods Related Thereto

Номер: US20170241938A1
Автор: Bulala Cherie, Myles Christopher, Simmons Matthew, Song Bonita Park
Принадлежит:

In some aspects, a modular analyte measurement system having a replaceable strip port module is provided to permit contaminated modules to be replaced. Some aspects of the present disclosure related to barriers for strip ports or the sealing of strip ports and/or analyte measurement devices to maintain a clean strip port and/or enable the strip port to be cleaned for reuse. Cleaning tools are also provided. Also provided are strip port interfaces that guide fluid away from the strip port opening, as well as absorptive elements that prevent fluid from entering a strip port. Analyte measurement devices with gravity sensors or accelerometers are also provided, along with methods related thereto. Also provided are docking station that serve as an information server and provides storage and recharging capabilities. 1. An analyte measurement system , comprising:an analyte meter having a meter housing and a processing circuit disposed within the housing; and a module housing, wherein the module housing includes a first aperture, which receives an analyte test strip, and an interface aperture,', 'an analyte test strip port disposed within the module housing, and', 'an electrical interface coupled to the analyte test strip port within the module housing and extending out of the housing through the interface aperture., 'a replaceable strip port module having'}2. The analyte measurement system of claim 1 , further comprising an attachment feature to removably attach the replaceable strip port module to the analyte meter.3. The analyte measurement system of claim 1 , wherein the module housing fits within an aperture in the meter housing.4. The analyte measurement system of claim 3 , wherein the module housing includes external alignment features to align the module housing within the aperture in the meter housing.5. The analyte measurement system of claim 3 , wherein the meter housing includes alignment features to align the module housing within the aperture in the meter ...

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Номер записи: 89
10-09-2015 дата публикации

Method and apparatus for the discrimination of the cell load in milk

Номер: US20150253302A1
Автор: Grit Schade-Kampmann, Marco Di Berardino
Принадлежит: Amphasys AG

A method is provided for the discrimination of cells from other particles, as well as of different types of cells in raw milk samples by impedance microflow cytometry. A method is provided of analysing the quality of raw milk in terms of its bacterial and somatic cell content without the need to pre-treat the milk sample, such that the analysis can take place directly at the production site. One advantage is discriminating and counting somatic cells from milk particles (consisting mainly of lipid vesicles) by high-frequency impedance analysis directly performed on untreated raw milk. Another advantage is that the method allows diagnosing the status of a mastitis infection directly after milking according to the analysis of the somatic cell count. Another advantage is to allow a fast method for determining the bacterial cell count in raw milk directly after milking. In addition, viability of both somatic and bacterial cells can be determined without the need of any cell label. A further advantage is, that the analysis can be obtained in real-time, directly after the raw milk has passed the micro channel of the microfluidic device.

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Номер записи: 90
01-08-2019 дата публикации

Assay Apparatus

Номер: US20190234929A1
Автор: Adelman Lonnie W., Bhagwath Nitin C.
Принадлежит:

Provided herein is an assay apparatus comprising at least one assay module; and a portable frame adapted to releasably retain the at least one assay module. The at least one assay module is adapted to perform at least one assay. The assay module comprises a sample receiver and an assay device operatively associated with the sample receiver. In some embodiments, the assay apparatus further comprises at least one functional module releasably retained by the portable frame. The functional module is operatively associated with the assay module when retained by the portable frame. 1. An assay apparatus , comprisingat least one assay module; anda portable frame adapted to releasably retain the at least one assay module,wherein the at least one assay module is adapted to perform at least one assay, the assay module comprising a sample receiver and an assay device operatively associated with the sample receiver.2. The assay apparatus of claim 1 , further comprising at least one functional module releasably retained by the portable frame claim 1 , the functional module being operatively associated with the assay module when retained by the portable frame.3. The assay apparatus of claim 2 , wherein the at least one functional module comprises a functional device selected from the group consisting of a battery claim 2 , a wireless data transmission device claim 2 , a wired data transmission device claim 2 , a microprocessor claim 2 , an interface for receiving and recording signals from at least one vital sign detector claim 2 , a luminescence recorder claim 2 , a display device claim 2 , a portable computing device claim 2 , a data storage device claim 2 , and combinations thereof4. The assay apparatus of claim 3 , wherein the at least one functional module comprises a battery claim 3 , and wherein the assay module further comprising a power inlet for receiving electric power from the battery.5. The assay apparatus of claim 3 , wherein the at least one functional module ...

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Номер записи: 91
13-11-2014 дата публикации

Microneedle arrays for biosensing and drug delivery

Номер: US20140336487A1
Автор: Joseph Wang, Joshua Ray Windmiller, Phillip Miller, Roger Narayan, Ronen Polsky, Thayne L. Edwards
Принадлежит: North Carolina State University, Sandia Corp, UNIVERSITY OF CALIFORNIA

Methods, structures, and systems are disclosed for biosensing and drug delivery techniques. In one aspect, â device for detecting an analyte and/or releasing a biochemical into a biological fluid can include an array of hollowed needles, in which each needle includes a protruded needle structure including an exterior wall forming a hollow interior and an opening at a terminal end of the protruded needle structure that exposes the hollow interior, and a probe inside the exterior wall to interact with one or more chemical or biological substances that come in contact with the probe via the opening to produce a probe sensing signal, and an array of wires that are coupled to probes of the array of hollowed needles, respectively, each wire being electrically conductive to transmit the probe sensing signal produced by a respective probe.

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Номер записи: 92
07-10-2021 дата публикации

Point-of-Birth System and Instrument, Biochemical Cartridge, and Methods for Newborn Screening

Номер: US20210311042A1
Автор: Donovan Bort, Vamsee Pamula, Vijay Srinivasan
Принадлежит: Baebies Inc

A point-of birth system and instrument, biochemical cartridge, and methods for newborn screening is disclosed. Namely, a point-of-birth system is provided the includes a point-of-birth instrument for receiving and processing a biochemical cartridge for performing newborn screening. Further, a portable smart device, such as a smartphone or tablet, is in communication with point-of birth instrument, wherein the smart device may include a newborn screening (NBS) mobile app. In one example, the point-of-birth system and point-of-birth instrument support newborn biological screening only. However, in another example, the point-of-birth system and point-of birth instrument support both newborn biological screening and newborn physiological screening.

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Номер записи: 93
14-09-2017 дата публикации

Test element analysis system for the analytical examination of a sample

Номер: US20170261490A1
Автор: Kai Hebestreit, Klaus Thome, Marina Swan Backhaus, Sylvia Saecker
Принадлежит: Roche Diagnostics GmbH, Roche Diagnostics Operations Inc

A test element analysis system for the analytical examination of a sample comprising: at least one evaluation device with at least one test element holder and at least one measuring device for measuring a change in a measuring zone of a test element; at least one barcode reader comprising at least one circuit board having a front side facing the barcode of the test element positioned in the test element holder and a reverse side facing away from the test element, wherein at least one electronic control element of the barcode reader is disposed on the circuit board and wherein the circuit board comprises at least one cavity penetrating the circuit board; at least one camera carrier element; and at least one camera electrically connected to the camera carrier element, with the camera carrier element and the camera being positioned such that the camera observes the barcode through the cavity.

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Номер записи: 94
13-09-2018 дата публикации

ELECTRONIC ANALYTE ASSAYING DEVICE

Номер: US20180259500A1
Автор: Bell Henry, NAZARETH Albert, Sturman Andy, Zin Benedict
Принадлежит: Church & Dwight, Co., Inc.

An improved electronic diagnostic device for detecting the presence of an analyte in a fluid sample comprises a casing having a display, a test strip mounted in the casing, a processor mounted in the casing, and a first sensor mounted in the casing and operatively coupled to the processor. The processor is configured to receive a signal from the first sensor when the device is exposed to ambient light thereby causing the device to become activated. The device includes a light shield that exerts pressure across a width of the test strip to prevent fluid channeling along the length of the test strip. The processor is configured to present an early positive test result reading when a measured value exceeds a predetermined early reading threshold value at any time after a predetermined early testing time period. 1. A method of making a diagnostic device , said diagnostic device comprising a casing , a processor mounted in said casing , and a first sensor operatively coupled to said processor , wherein said first sensor is configured to provide a signal to said processor when said first sensor detects ambient light , and said diagnostic device is capable of detecting the presence of an analyte in a fluid sample once activated , said method comprising covering said first sensor of said diagnostic device so as to prevent said first sensor from sensing ambient light thereby preventing said diagnostic device from activating.2. The method of claim 1 , wherein the device receives power from a power source when said first sensor senses ambient light.3. The method of claim 2 , wherein the power source is internal to the device.4. The method of claim 1 , wherein the step of covering said diagnostic device further comprises sealing said diagnostic device in a light impervious material.5. The method of claim 4 , wherein said light impervious material is a wrapper.6. The method of claim 1 , wherein said diagnostic device comprises a light port for directing ambient light to said ...

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Номер записи: 95
22-09-2016 дата публикации

Fluids testing apparatus and methods of use

Номер: US20160274083A1
Автор: David Weintraub, Dov OPPENHEIM, Eyal Cohen, Meir Plevinski, Oren Fuerst
Принадлежит: Labstyle Innovation Ltd

The invention is directed to a mobile hand held miniature laboratory system in general, and to fluid testing apparatus for performing a parameter measurement in a fluid sample and methods of use in particular. The apparatus comprising: a strip adapted to absorb a fluid sample and to produce a signal indicative of said parameter level in said sample; and adaptor adapted to connect said strip to a smart phone to allow delivery of the produced signal or a correlated signal to said smart phone for obtaining a measurement of said fluid parameter displayed on said smart phone, wherein said testing apparatus relies on said smart phone at least for power supply and display means. The fluid may be a physiological fluid such as blood, urine, saliva or amniotic fluid, or a non-physiological fluid such as fluid obtained from industrial pools for fish or algae growth, or entertainment swimming pools.

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Номер записи: 96
21-09-2017 дата публикации

Analyte Monitoring Devices and Methods Therefor

Номер: US20170269023A1
Автор: Jennewine R. Curtis, Sloan Mark K.
Принадлежит:

Method and apparatus for performing a discrete glucose testing and bolus dosage determination including a glucose meter with bolus calculation function are provided.

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Номер записи: 97
01-10-2015 дата публикации

Connector for biological information measurement, and biological information measurement device using same

Номер: US20150280350A1
Автор: Kaoru Shigematsu, Yoshiki Takeuchi
Принадлежит: Panasonic Healthcare Holdings Co Ltd

In the present invention, a metal upper cover that covers an upper face opening of a frame is mounted on this upper face opening, and a bent piece that is inserted into a bent piece insertion hole provided to the frame is provided to a portion of the upper face cover on the side of a sensor insertion hole. Furthermore, ground connection pieces formed by extending the outside of the left and right sides of the frame from the upper face toward the lower face are provided in portions opposite the left and right edges linked to the edge of the top cover on which the sensor insertion opening of the frame is provided.

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Номер записи: 98
22-08-2019 дата публикации

RAPID CHARGING AND POWER MANAGEMENT OF A BATTERY-POWERED FLUID ANALYTE METER

Номер: US20190260214A1
Автор: CHEN Jun, Gofman Igor
Принадлежит:

A system and method is described for rapid charging and power management of a battery for a meter. A charger component is operably associated with the meter and is capable of executing a rapid charge algorithm for a rechargeable battery. The algorithm includes monitoring for a connection to an external power source and implementing a charging routine of a battery at a first charge rate and then at a second charge rate. The second charge rate is lower than the first charge rate. A temperature rise in the rechargeable battery due to the first charge rate has a negligible heat transfer effect on the fluid sample. The meter can also include a power switch for controlling current flow to a battery fuel gauge. The power switch is open when the meter enters into a sleep mode. The state of battery charge is determined after the meter exits the sleep mode. 134-. (canceled)35. A battery-powered meter adapted to determine a temperature-sensitive fluid analyte concentration of a fluid sample , a determination of fluid analyte concentration by the meter having an approximated energy draw , the meter comprising:a housing defining an area for receiving a rechargeable battery and a port sized for receiving at least a portion of a test sensor; and (i) monitoring the rechargeable battery for a remaining battery charge; and', '(ii) in response to the remaining battery charge being below a predetermined charge value associated with completing up to approximately ten fluid analyte concentration tests based on the approximated energy draw, implementing a rapid charge routine for charging the rechargeable battery for one minute or less at a charge rate of 2 C or less,, 'a microprocessor disposed within the housing, the microprocessor configured to implement a charge process associated with the rechargeable battery, the charge process comprising the acts ofwherein implementing the rapid charge routine provides enough energy to the rechargeable battery to allow one or more analyte ...

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Номер записи: 99
08-10-2015 дата публикации

APPARATUS AND METHOD FOR DETERMINING DISTRIBUTION VOLUME IN DIALYSIS PATIENT

Номер: US20150285782A1
Автор: Meibaum Joern, STROHHOEFER CHRISTOF, Wolff Henrik
Принадлежит:

Apparatus and control methods for determining a distribution volume of at least one uremic substance in a dialysis patient are disclosed. The apparatus may include a dialyzer, an optional flow rate measuring system for detecting the flow rate of a dialysis fluid through the dialyzer, a dialysis fluid measuring system for detecting at least one dialysis fluid parameter that depends on the at least one substance in the dialysis fluid, and a computer for establishing a dialysis dose based on the dialysis fluid parameter and for establishing the distribution volume based on the dialysis dose taking a clearance factor and dialysis duration into account. 115-. (canceled)16. An apparatus for determining a distribution volume of at least one uremic substance in a dialysis patient , comprising:a dialyzer for withdrawing the at least one uremic substance from a body fluid, the dialyzer adapted for dialysis fluid flowing through the dialyzer to dispose of the at least one withdrawn substance;a dialysis fluid measuring system for detecting at least one dialysis fluid parameter that depends on the at least one uremic substance in the dialysis fluid; andat least one computer configured to establish a dialysis dose based on the at least one dialysis fluid parameter and to establish the distribution volume based on the dialysis dose taking a clearance factor and dialysis duration into account.17. The apparatus according to claim 16 , further comprising:a flow rate measuring system for detecting a flow rate of the dialysis fluid through the dialyzer.18. The apparatus according to claim 16 , wherein the computer establishes the dialysis dose based on measured optical extinction of the dialysis fluid.19. The apparatus according to claim 16 , wherein the computer establishes the dialysis dose based on measured conductivity of the dialysis fluid.20. The apparatus according to claim 16 , wherein the computer establishes the dialysis dose based on a detected chemical reaction.21. The ...

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