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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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Применить Всего найдено 261831. Отображено 100.
05-01-2012 дата публикации

HIV/AIDS Treatment Efficacy Measure

Номер: US20120002209A1
Автор: Satish Deshpande
Принадлежит: Individual

A white blood cell nuclei light scattering peak resolving process measures efficacies of treatment agents against an HIV/AIDS infection of a person by calculating changes between Mie scatterings from blood from the person and from blood from the person with a treatment agent added, where the Mie scatterings resolve the first Mie light scattering peak of white blood cell nuclei.

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Номер записи: 1
05-01-2012 дата публикации

Recombinant fusion protein and polynucleotide construct for immunotoxin production

Номер: US20120003223A1
Автор: Itai Benhar, Yariv Mazor
Принадлежит: Ramot at Tel Aviv University Ltd

The present invention relates to a polynucleotide construct encoding a fusion protein consisting of a domain which binds the immunoglobulin Fc region, genetically fused to a truncated form of Pseudomonas exotoxin A (PE). In particular, the invention discloses the fusion protein, ZZ-PE38, and further provides immunotoxins, formed from complexes of the fusion protein with antibodies for targeted cell killing.

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Номер записи: 2
05-01-2012 дата публикации

Yeast ectopically expressing abnormally processed proteins and uses therefor

Номер: US20120003243A1
Автор: Susan L. Lindquist, Tiago Outeiro
Принадлежит: WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH

Disclosed are yeast ectopically expressing abnormally processed proteins and methods of screening to identify compounds that modulate the function of such abnormally processed proteins in yeast. Compounds identified by such screens can be used to treat or prevent diseases associated with abnormally processed proteins or protein misfolding. Such diseases include Parkinson's Disease, Parkinson's Disease with accompanying dementia, Lewy body dementia, Alzheimer's disease with Parkinsonism, and multiple system atrophy.

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Номер записи: 3
05-01-2012 дата публикации

Biological control of nanoparticle nucleation, shape and crystal phase

Номер: US20120003629A9
Автор: Angela Belcher, Esther Ryan, Richard Smalley, Seung-Wuk Lee
Принадлежит: University of Texas System

The present invention includes compositions and methods for selective binding of amino acid oligomers to semiconductor and elemental carbon-containing materials. One form of the present invention is a method for controlling the particle size of the semiconductor or elemental carbon-containing material by interacting an amino acid oligomer that specifically binds the material with solutions that can result in the formation of the material. The same method can be used to control the aspect ratio of the nanocrystal particles of the semiconductor material. Another form of the present invention is a method to create nanowires from the semiconductor or elemental carbon-containing material. Yet another form of the present invention is a biologic scaffold comprising a substrate capable of binding one or more biologic materials, one or more biologic materials attached to the substrate, and one or more elemental carbon-containing molecules attached to one or more biologic materials.

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Номер записи: 4
05-01-2012 дата публикации

Method for measuring physiologically active substance of biological origin, program for implementing the same, and apparatus for measuring physiologically active substance of biological origin

Номер: US20120003745A1
Автор: Katsumi Yabusaki, Takuya Hara, Yuka Sugiura
Принадлежит: Kowa Co Ltd

When assessing the start time of the limulus reaction between biogenous biologically active substances and LAL and using the reaction start time to determine the concentration of the biogenous biologically active substances, in order to exclude the influence of progressive changes which occur regardless of the conditions of the limulus reaction, the strength of transmitted light or scattered light in the liquid mixture of the measurement sample and LAL is detected, the variation (delta) in the transmittance or number of gel particles is acquired at set intervals, and the time when the variation (delta) crosses a threshold value is taken as the reaction start time. Furthermore, the time intervals when acquiring the abovementioned delta are not uniform, and either change over time from the start of measurement as defined by a time function, or multiple sequences with differing time intervals are prepared in advance.

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Номер записи: 5
05-01-2012 дата публикации

Gene expression markers of oncolytic virus sensitivity

Номер: US20120004119A1
Автор: Lynda Chin, Marc Lenburg
Принадлежит: Lynda Chin, Marc Lenburg

A method of predicting an efficacy of an oncolytic virus treatment for a tumor comprises calculating a single-gene predictor score for each of a plurality of genes; calculating a predictor score from the sum of the single-gene predictor scores for the plurality of genes; and predicting, if the predictor score is greater than a predictor score threshold, that the treatment would have efficacy, and if the predictor score is less than a predictor score threshold, that the treatment would lack efficacy. Also, methods of predicting an efficacy of a treatment for a tumor comprise identifying the type and subtype of the tumor, wherein the efficacy of the treatment for the type and subtype of the tumor is known.

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Номер записи: 6
05-01-2012 дата публикации

Biomarkers for inhibitors with anti-angiogenic activity

Номер: US20120004129A1
Автор: Joyce Behrens
Принадлежит: Merck Patent GmBH

The invention relates to a method for assessing the effect of integrin inhibitors and small molecule ATP site directed multi kinase inhibitors on angiogenesis by the use of certain identified biomarkers. This method is notably beneficial for the determination of the efficacy of integrin inhibitors and small molecule ATP site directed multi-kinase inhibitors mainly used for the treatment of angiogenesis associated diseases such as cancer. Especially, the invention relates to biomarkers linked to angiogenesis that are preferably accessible in body fluids and therefore allow analysis of target modulation in a non-invasive way. The use of said biomarkers for the screening of compounds with integrin-inhibitory activity is also disclosed.

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Номер записи: 7
05-01-2012 дата публикации

Materials and methods for treatment of cancer and identification of anti-cancer compounds

Номер: US20120004169A1
Автор: Richard Jove, Said M. Sebti
Принадлежит: UNIVERSITY OF SOUTH FLORIDA

The subject invention pertains to the treatment of tumors and cancerous tissues and the prevention of tumorigenesis and malignant transformation through the modulation of JAK/STAT3 intracellular signaling. The subject invention concerns pharmaceutical compositions containing cucurbitacin I, or a pharmaceutically acceptable salt or analog thereof. Another aspect of the invention concerns methods of inhibiting the growth of a tumor by administering a cucurbitacin I, or a pharmaceutically acceptable salt or analog thereof, to a patient, wherein the tumor is characterized by the constitutive activation of the JAK/STAT3 intracellular signaling pathway. The present invention further pertains to methods of moderating the JAK and/or STAT3 signaling pathways in vitro or in vivo using cucurbitacin I, or a pharmaceutically acceptable salt or analog thereof. Another aspect of the present invention concerns a method for screening candidate compounds for JAK and/or STAT3 inhibition and anti-tumor activity.

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Номер записи: 8
05-01-2012 дата публикации

Modulators of atp-binding cassette transporters

Номер: US20120004216A1
Автор: Ashvani K. Singh, Lewis R. Makings, Mark T. Miller, Matthew Hamilton, Peter D.J. Grootenhuis, Sara S. Hadida Ruah, Thomas Cleveland
Принадлежит: Vertex Pharmaceuticals Inc

The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including CF Transmembrane Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.

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Номер записи: 9
05-01-2012 дата публикации

Biosensor coated with electroactive polymer layer demonstrating bending behavior

Номер: US20120004522A1
Автор: Jang-Hyun Youn, Seon-Jeong Kim, Sun Ill Kim
Принадлежит: Industry University Cooperation Foundation IUCF HYU

Disclosed is a biosensor coated with an electroactive polymer layer demonstrating a bending behavior, more specifically a biosensor including an electroactive polymer layer coated on the surface of a bioreceptor and an electrode connected to the electroactive polymer layer. When an electrical stimulation is applied to the electrode, the electroactive polymer layer shows a bending behavior and thus the surface of the bioreceptor can be exposed to an analyte to allow a concentration analysis of the analyte. When used as an implantable biosensor, the disclosed biosensor may have a substantially increased life span since the bioreceptor can be selectively exposed to the analyte.

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Номер записи: 10
21-02-2017 дата публикации

Диагностическая тест система для первичной диагностики патологии молочной железы при наличии выделений из соска

Номер: RU0000168868U1
Автор: Александр Александрович Баранов, Александр Геннадьевич Попов, Лейла Сеймуровна Намазова-Баранова, Максим Тимурович Травин, Марина Львовна Травина, Михаил Владимирович Молодчинин, Сергей Александрович Попов
Принадлежит: Федеральное государственное автономное учреждение "Научный центр здоровья детей" Министерства здравоохранения Российской Федерации (ФГАУ "НЦЗД" Минздрава России)

Полезная модель относится к медицине и может применяться врачами первичного звена при профилактическом осмотре женщин для диагностики патологических изменений молочной железы при наличии выделений из соска. Диагностическая тест-система представляет собой тест-полоску с нанесенными на нее десятью зонами разного цвета, предназначенными для визуального анализа выделений из соска молочной железы. Цвет выделений сравнивают с цветом одной из зон тест-полоски, при этом соответствие зонам 0-5 является показателем дисгормональных процессов в молочной железе, соответствие зонам 6-9 является показателем патологического процесса, при котором необходимо цитологическое исследование. Тест-система позволяет на ранней стадии диагностики быстро, просто и достаточно надежно проводить диагностику патологии молочной железы при наличии выделений из соска. В эксплуатации тест-система довольно проста и эффективна. Тест-система может применяться врачами первичного звена при профилактическом осмотре женщин. РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 168 868 U1 (51) МПК G01N 33/53 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ФОРМУЛА ПОЛЕЗНОЙ МОДЕЛИ К ПАТЕНТУ РОССИЙСКОЙ ФЕДЕРАЦИИ (21)(22) Заявка: 2016122660, 08.06.2016 (24) Дата начала отсчета срока действия патента: 08.06.2016 21.02.2017 Приоритет(ы): (22) Дата подачи заявки: 08.06.2016 1 6 8 8 6 8 R U (56) Список документов, цитированных в отчете о поиске: RU 49276 U1, 10.11.2005. RU 2002134681 А, 20.07.2004. RU 2442988 С1, 20.02.2012. RU 115074 U1, 20.04.2012. RU 2523393 С1, 20.07.2014. CN 101539577 A, 23.09.2009. CN 101539578 A, 23.09.2009. (54) Диагностическая тест система для первичной диагностики патологии молочной железы при наличии выделений из соска (57) Формула полезной модели Диагностическая тест-система для первичной диагностики патологии молочной железы при наличии выделений из соска, представляющая собой тест-полоску с нанесенными на нее десятью зонами разного цвета, предназначенными для визуального анализа ...

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Номер записи: 11
06-07-2017 дата публикации

Универсальный адаптер для использования микрочипов планарного типа в планшетных ридерах для иммунофлуоресцентного анализа

Номер: RU0000172401U1
Автор: Игорь Руфаилович Набиев, Павел Сергеевич Самохвалов
Принадлежит: федеральное государственное автономное образовательное учреждение высшего образования "Национальный исследовательский ядерный университет "МИФИ" (НИЯУ МИФИ)

Полезная модель относится к области медицинских исследований методом иммуноферментного анализа (ИФА) с применением микрочипов планарного типа, на которых собирается иммуносэндвич. Также, данное устройство предназначено для обеспечения точности позиционирования микрочипов планарного типа любой конфигурации в стандартных планшетных ридерах для ИФА при проведении исследовательских и испытательных работ в области разработки новых типов планарных микрочипов для ИФА, например, с применением массивов нанопроволочных структур в аналитической области планарного микрочипа.Сущность полезной модели заключается в том, что универсальный адаптер для использования микрочипов планарного типа в планшетных ридерах для ИФА, содержит основание, размеры которого соответствуют размеру основания планшета для ИФА, и держатель для размещения и фиксации микрочипов, который дополнен возможностью перемещения микрочипа по трем пространственным осям X, Y и Z в пределах габаритов планшета для ИФА.Техническим результатом полезной модели является возможность точного и воспроизводимого позиционирования микрочипов планарного типа в трех пространственных измерениях, в пределах габаритов планшета для ИФА, что позволяет использовать микрочип планарного типа в качестве подложки для проведения ИФА и считывать сигнал на любом ридере для ИФА планшетов. 14 з.п. ф-лы, 1 ил. Ц 1 172401 ко РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ п РЦ ‘’ (50) МПК СОМ 33/53 (2006.01) СО2В 21/26 (2006.01) п“ х хз < 3 х р р 2 р Ул (12) ОПИСАНИЕ ПОЛЕЗНОЙ МОДЕЛИ К ПАТЕНТУ (21)(22) Заявка: 2016125963, 29.06.2016 (24) Дата начала отсчета срока действия патента: 29.06.2016 Дата регистрации: 06.07.2017 Приоритет(ы): (22) Дата подачи заявки: 29.06.2016 (45) Опубликовано: 06.07.2017 Бюл. № 19 Адрес для переписки: 115409, Москва, Каширское ш., 31, НИЯУ МИФИ ОУИС УНИ, Бейгул Г.В. (72) Автор(ы): Набиев Игорь Руфаилович (КО), Самохвалов Павел Сергеевич (КП) (73) Патентообладатель(и): федеральное ...

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Номер записи: 12
04-06-2019 дата публикации

Микрофлюидное устройство для исследования влияния химических веществ на клетки млекопитающих

Номер: RU0000189789U1
Автор: Александр Григорьевич Тоневицкий, Дмитрий Андреевич Сахаров
Принадлежит: Общество с ограниченной ответственностью Научно-технический центр &#34;БиоКлиникум&#34;

Полезная модель относится к области биохимии и может быть использована для исследования влияния различных химических веществ на клетки млекопитающих в условиях in vitro, в частности, может применяться для проведения стандартизованных однотипных одномоментных независимых доклинических исследований гепатотоксичности и/или биотрансформации лекарственных средств.Техническим результатом является сокращение временных затрат на проведение исследований при реализации in vitro условий культивирования, максимально приближенных к физиологическим.Микрофлюидное устройство для исследования влияния химических веществ на клетки млекопитающих представляет собой чип с размещенной в нем микрофлюидной системой, при этом микрофлюидная система выполнена в виде четырех однотипных независимых замкнутых контуров для циркуляции питательной среды, каждый из которых включает объединенные микрожидкостными каналами микронасос для обеспечения движения питательной среды в контуре, клеточную ячейку для культивирования клеточных моделей тканей и органов млекопитающих, демпфирующий элемент для гашения скачков давления и скорости движения питательной среды в контуре и технологическое отверстие для доступа к питательной среде в контуре. 13 з.п. ф-лы, 8 ил. РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 189 789 U1 (51) МПК G01N 33/50 (2006.01) C12M 3/00 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ОПИСАНИЕ ПОЛЕЗНОЙ МОДЕЛИ К ПАТЕНТУ (52) СПК G01N 33/5008 (2019.02); C12M 3/00 (2019.02); G01N 2500/10 (2019.02) (21)(22) Заявка: 2018131851, 05.09.2018 с присоединением заявки №2016152533 05.09.2018 (73) Патентообладатель(и): Общество с ограниченной ответственностью Научно-технический центр "БиоКлиникум" (RU) Дата регистрации: 04.06.2019 2016152533 30.12.2016 (56) Список документов, цитированных в отчете о поиске: RU 2584598 C1, 20.05.2016. RU 171690 U1, 09.06.2017. US 20170248583 A1, 31.08.2017. US 20110045582 A1, 24.12.2011. (45) Опубликовано: 04.06.2019 Бюл. № 16 U 1 1 8 9 7 8 9 R U (54) ...

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Номер записи: 13
20-03-2020 дата публикации

Устройство для иммунохроматографической одновременной индивидуальной детекции фторхинолоновых антибиотиков офлоксацина, энрофлоксацина и ципрофлоксацина в продуктах питания

Номер: RU0000196919U1
Автор: Анатолий Виталиевич Жердев, Борис Борисович Дзантиев, Надежда Алексеевна Бызова, Надежда Алексеевна Таранова
Принадлежит: Федеральное государственное учреждение &#34;Федеральный исследовательский центр &#34;Фундаментальные основы биотехнологии&#34; Российской академии наук&#34; (ФИЦ Биотехнологии РАН)

Заявленное устройство предназначено для иммунохроматографической экспрессной лабораторной и внелабораторной одновременной индивидуальной детекции токсичных контаминантов - фторхинолоновых антибиотиков (офлоксацина, энрофлоксацина, ципрофлоксацина) в продуктах питания. Устройство представляет собой мультимембранный композит с нанесенными иммунореагентами (тест-полоску). Мультимембранный композит состоит из рабочей нитроцеллюлозной мембраны на твердой полистироловой основе с нанесенными иммунореагентами, стекловолоконной мембраны с нанесенными иммунореагентами, мембраны для впитывания и сепарации исследуемой пробы и конечной адсорбирующей мембраны для впитывания компонентов пробы после прохождения реакции. Отличительной особенностью заявленного устройства является то, что в контрольную зону (К.З.) нанесены поликлональные козьи антитела, специфичные к иммуноглобулинам кролика. В первую тестовую зону (Т.З.1) нанесен конъюгат офлоксацина с белком-носителем соевым ингибитором трипсина (СИТ). Во вторую тестовую зону (Т.З.2) нанесен конъюгат энрофлоксацина с белком-носителем СИТ. В третью тестовую зону (Т.З.3) нанесен конъюгат ципрофлоксацина с белком-носителем СИТ. На стекловолоконную мембрану нанесена смесь конъюгатов с коллоидным золотом поликлональных кроличьих антител, специфичных к офлоксацину, энрофлоксацину и ципрофлоксацину. Для проведения анализа не требуется никаких дополнительных приспособлений. Продолжительность анализа составляет 10 мин без учета пробоподготовки. Технической задачей заявленной полезной модели является одновременная индивидуальная детекция трех токсичных контаминантов - фторхинолоновых антибиотиков офлоксацина, энрофлоксацина и ципрофлоксацина в продуктах питания. Технический результат заявленной полезной модели заключается в одновременной индивидуальной детекции на одной тест-полоске офлоксацина, энрофлоксацина и ципрофлоксацина с использованием простой одностадийной процедуры проведения анализа, обеспечиваемой за счет нанесения на тест- ...

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Номер записи: 14
05-01-2012 дата публикации

Animal model for parkinson's disease

Номер: US20120005765A1
Автор: Michael Panneton, Vijaya Kumar, William Burke
Принадлежит: St Louis University

Disclosed are methods and compositions for an animal model of Parkinson's disease. In particular, disclosed is the use of antisense compounds to inhibit the expression of ALDH1A1 in the substantia nigra of an animal brain for the purpose of creating an animal that will displays the symptoms of a human with Parkinson's Disease, including various biochemical, histological, and behavioral characteristics. Also disclosed are methods for using the animal model for Parkinson's disease to test potential therapeutic agents for Parkinson's disease.

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Номер записи: 15
19-11-2021 дата публикации

Датчик для неинвазивного измерения концентрации глюкозы

Номер: RU0000207850U1
Автор: Александр Владимирович Горст, Александр Сергеевич Мироньчев, Андрей Владимирович Клоков, Андрей Сергеевич Запасной, Владимир Петрович Якубов, Ксения Владимировна Завьялова
Принадлежит: Федеральное государственное автономное образовательное учреждение высшего образования «Национальный исследовательский Томский государственный университет»

Предложенная полезная модель представляет собой базовую конструкцию датчика, предназначенного для неинвазивного мониторинга концентрации глюкозы в биологических тканях, и может быть использована для создания неинвазивного глюкометра для непрерывного мониторинга концентрации глюкозы.Датчик для неинвазивного измерения концентрации глюкозы состоит из диэлектрической подложки, первого металлического слоя, нанесенного на одной стороне подложки, второго металлического слоя, нанесенного на другой стороне подложки, и имеет широкую полосу рабочей частоты. Первый металлический слой состоит из расположенных на одной оси в центре подложки двухпетлевого, петлевого и щелевого вибраторов и обеспечивает формирование и пролонгирование ближнего поля, обеспечивающего высокую чувствительность датчика 0,5–0,7 дБ/(ммоль/л). Щелевой вибратор выполнен в виде рамки. Второй металлический слой представляет собой металлическую микрополосковую линию, через конец которой происходит запитывание всей конструкции. Внутри диэлектрической подложки находится металлический цилиндр, через который соединяются первый и второй металлические слои. РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 207 850 U1 (51) МПК A61B 5/145 (2006.01) H01Q 1/38 (2006.01) H01Q 7/00 (2006.01) H01Q 13/10 (2006.01) G01N 22/00 (2006.01) G01N 33/50 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ОПИСАНИЕ ПОЛЕЗНОЙ МОДЕЛИ К ПАТЕНТУ (52) СПК A61B 5/145 (2021.08); H01Q 1/38 (2021.08); H01Q 7/00 (2021.08); H01Q 13/10 (2021.08); G01N 22/00 (2021.08); G01N 33/50 (2021.08) (21)(22) Заявка: 2021114355, 21.05.2021 21.05.2021 Дата регистрации: 19.11.2021 (45) Опубликовано: 19.11.2021 Бюл. № 32 2 0 7 8 5 0 R U (56) Список документов, цитированных в отчете о поиске: CN 103892843 A, 02.07.2014. CN 108899641 A, 27.11.2018. CN 111555017 A, 18.08.2020. CN 109350077 A, 19.02.2019. US 2019104939 A1, 11.04.2019. US 2019231237 A1, 01.08.2019. WO 2018062703 A1, 05.04.2018. KR 20180088156 A, 03.08.2018. KR 101974284 B1, 30.04.2019. RU ...

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Номер записи: 16
12-01-2012 дата публикации

Test strip with slot vent opening

Номер: US20120009095A1
Автор: David W. Burke, Michael Marquant
Принадлежит: Roche Diagnostics Operations Inc

Methods of manufacturing test strips are disclosed. Embodiments include laminating a two piece covering layer over a substrate with a series of cavities, wherein the two pieces are separated by a gap, the gap forming a vent opening for the cavities. Other embodiments include covering the sample receiving chamber with a cover thinner than the cover covering the body of the test strip, the thicker body cover absorbing more force than the chamber cover to reduce the possibility of adhesives squeezing out from under the chamber cover. The present invention also provides an advantageous method of mass-producing the inventive test strips without having to align the slot or vent opening laterally with respect to the test strips and without having to punch a vent opening. The method is also well suited to mass production by roll processing techniques.

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Номер записи: 17
12-01-2012 дата публикации

Methods of predicting responsiveness to interferon treatment and treating hepatitis c infection

Номер: US20120009148A1
Автор: Yoav Smith
Принадлежит: Yissum Research Development Co of Hebrew University of Jerusalem

Provided are methods of predicting responsiveness of a subject to interferon treatment, comprising comparing a level of expression in a cell of the subject of at least one gene selected from the group consisting KIR3DL3, KIR3DL2, KIR3DL1, KIR2DL1, KIR2DL2, KIR2DL3, KLRG1, KIR3DS1, CD160, HLA-A, HLA-B, HLA-C, HLA-F, HLA-G and IFI27 to a reference expression data of the at least one gene obtained from at least one interferon responder subject and/or at least one interferon non-responder subject. Also provided are methods and pharmaceutical compositions for treating a subject in need of interferon treatment.

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Номер записи: 18
12-01-2012 дата публикации

Biomarkers for myocardial ischemia

Номер: US20120009174A1
Автор: Jennifer Van Eyk, QIN Fu, Simon Sheng
Принадлежит: JOHNS HOPKINS UNIVERSITY

This invention relates, e.g., to a method for determining if a subject has myocardial ischemia, comprising (a) providing a blood sample obtained from a subject suspected of having myocardial ischemia; (b) determining in the sample the amount of one or more of the following proteins: (i) Lumican and/or (ii) Extracellular matrix protein 1 and/or (iii) Carboxypeptidase N; and (c) comparing the amount(s) of the protein(s) to a baseline value that is indicative of the amount of the protein in a subject that does not have myocardial ischemia, wherein a statistically significantly increased amount of the protein(s) compared to the baseline value is indicative of myocardial ischemia. Other proteins indicative of myocardial ischemia are also described, as are methods for treating a subject based on a diagnostic procedure of the invention, and kits for carrying out a method of the invention.

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Номер записи: 19
12-01-2012 дата публикации

Renal cell carcinoma biomarkers

Номер: US20120009201A1
Автор: Bih-Rong Wei, Donald J. Johann, Josip Blonder, Timothy D. Veenstra
Принадлежит: US Department of Health and Human Services

Disclosed herein is a method of identifying a tumor biomarker. In one example, a tumor biomarker is identified by obtaining a peripheral biological fluid sample from a subject with a tumor as well as a tumor sample and an adjacent non-tumor sample from such subject. A protein expression profile is detected in the peripheral biological fluid sample, tumor sample and adjacent non-tumor sample. The protein expression profiles of the peripheral biological fluid sample, tumor sample and adjacent non-tumor sample are then compared, wherein an increase in expression of a specific protein in the tumor sample and peripheral biological fluid sample but not in the adjacent non-tumor sample indicates that the specific protein is a biomarker of the tumor. Also disclosed herein is a gene profiling signature that can be used to diagnosis a subject with renal cell carcinoma (RCC) or to identify agents with therapeutic potential to treat RCC. Thus, methods of diagnosing a subject with RCC are disclosed. Methods are also provided for identifying agents that alter an activity of a RCC biomarker.

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Номер записи: 20
12-01-2012 дата публикации

Method for detecting membrane protein internalization

Номер: US20120009599A1
Автор: Eric Trinquet, Herve Ansanay, Jurriaan Zwier, Michel Fink, Robert Poole
Принадлежит: CIS Bio International SA

A method for detecting the internalization of a transmembrane protein of interest expressed at the surface of a cell, comprising the following steps: a) labelling the protein of interest with a fluorescent metal complex, the lifetime of which is greater than 0.1 ms; b) adding to the reaction medium a composition capable of causing the internalization of the protein of interest; c) adding to the reaction medium a modulating agent selected from: a. a fluorescent or nonfluorescent FRET acceptor compound compatible with said fluorescent metal complex, the final concentration of which in the reaction medium is greater than 10 −7 M; b. a reducing agent, the redox potential of which is less than +0.1 V and preferably between 0.25 and 0.75 V; c. an agent which binds specifically, by noncovalent bonding, with the fluorescent metal complex; d. a metal ion which competes with the rare earth so as to form a nonfluorescent metal complex; d) measuring the luminescence emitted by the reaction medium at the emission wavelength of the fluorescent metal complex and/or at the emission wavelength of the modulating compound when said compound is a fluorescent acceptor compound; e) comparing the signal measured in step d) with a reference signal measured on cells having been subjected only to steps a) and c).

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Номер записи: 21
12-01-2012 дата публикации

Devices and methods for detecting amniotic fluid in vaginal secretions

Номер: US20120009609A1
Автор: Alexandr Konstantinov, Boris Fuks, Dmitrii D. Petrunin, Evgeny I. Zaraisky, Margarita I. Marshiskaia, Marina N. Boltovskaya, Nelly A. Starosvetskaya, Svetlana V. Nazimova
Принадлежит: N Dia Inc

The present invention relates to a diagnostic method for the detection of small quantities of amniotic fluid in the vagina. More specifically, the invention relates to the detection of PAMG-1 in the vagina using anti-PAMG-1 antibodies.

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Номер записи: 22
12-01-2012 дата публикации

Method for distributing contact information between applications

Номер: US20120009902A2
Автор: Jon Peterson, Peter Davis, Webb Dryfoos
Принадлежит: Individual

A method and system for distributing contacting information between applications is provided. The system preferably uses an ENUM-type protocol and a middleware tool kit to associate telephone numbers to other identifying information, such as e-mail addresses or URLs for web sites. The system enables the associated contacting information to be shared across multiple applications that may be implemented on a computer or a mobile telephony device. Information is shared only after verification that a requester is authorized to receive the requested contacting information.

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Номер записи: 23
12-01-2012 дата публикации

Methods of treating neurodegenerative disorders and diseases

Номер: US20120010196A1
Автор: Quingyu QIN, Xiaoning Bl
Принадлежит: WESTERN UNIVERSITY OF HEALTH SCIENCES

This invention is directed to a novel method of treating neurodegenerative disorders and diseases. Another, related aspect of this invention is directed to a screening method of identifying compounds that can be used to treat neurodegenerative disorders and diseases. The foregoing aspects of the invention particularly relate to neurodegenerative disorders and diseases have degeneration of neuronal axons as part of their pathologies. The method of treatment involves administering a pharmaceutical formulation that comprises a compound or mixture of compounds that inhibits one or more intracellular signaling mechanism that regulate axon degeneration or growth cone collapse. The screening method aspect of the invention identifies test compounds that can be used for the treatment or prevention of neurodegenerative disorders based on the test compound's ability to inhibit axon degeneration or growth cone collapse.

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Номер записи: 24
19-01-2012 дата публикации

Anti-polyethylene glycol antibody expressing cell quantify any free polyethylene glycol and polyethylene glycol-derivatized molecules

Номер: US20120015380A1
Автор: Kuo-Hsiang Chuang, Ssu-Jung Lu, Steven R. Roffler, Tian-Lu Cheng
Принадлежит: KAOHSIUNG MEDICAL UNIVERSITY

In this invention, anti-PEG antibodies or anti-methoxyl-PEG (anti-CH 3 O-PEG) antibodies were expressed on cell surface which can collocate with a biotinylated anti-PEG antibody (AGP4-Biotin) or biotinylated PEG (PEG-Biotin) to develop a cell-based sandwich ELISA or a cell-based competition ELISA, respectively. Both of these two methods could sensitively quantify free PEG and PEG-modified macromolecules (proteins, nanoparticles and liposomes) as sensitive as nano-gram level.

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Номер записи: 25
19-01-2012 дата публикации

Novel diagnostic marker for type 1 diabetes mellitus

Номер: US20120015383A1
Автор: Kyong Soo Park, Sang Gyu Park, Sunghoon Kim
Принадлежит: SEOUL NATIONAL UNIVERSITY HOSPITAL, SNU R&DB FOUNDATION

The present invention provides, as a novel diagnosis marker for type 1 diabetes mellitus, a type 1 diabetes mellitus diagnostic composition comprising alanyl-tRNA synthetase, glycyl-tRNA synthetase, asparaginyl-tRNA synthetase, or tryptophanyl-tRNA synthetase, a diagnostic kit comprising the same, and a diagnostic method using the same. The composition, the kit, and the method, according to the present invention, may be used for early diagnosis and confirmed diagnosis of type 1 diabetes mellitus because type 1 diabetes mellitus can be easily diagnosed from a patient sample.

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Номер записи: 26
19-01-2012 дата публикации

Mek mutations conferring resistance to mek inhibitors

Номер: US20120015973A1
Автор: Carlos Garcia Echeverria, Caroline Emery, Levi A. Garraway
Принадлежит: Dana Farber Cancer Institute Inc, NOVARTIS AG

The present invention relates to methods, compositions and kits concerning resistance to treatment with an anti-cancer agent, specifically an inhibitor of MEK. In particular embodiments, the invention concerns mutations in a MEK sequence that confer resistance to a MEK inhibitor. Identification of such mutations in a MEK sequence allows the identification and design of second-generation MEK inhibitors. Methods and kits for detecting the presence of a mutant MEK sequence in a sample are also provided.

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Номер записи: 27
26-01-2012 дата публикации

Methods and compositions for liver cancer therapy

Номер: US20120020961A1
Автор: Anne-Sophie Dume, Dominique Joubert, Frédéric HOLLANDE, Leïla Houhou
Принадлежит: Biorealites SAS, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS, Institut National de la Sante et de la Recherche Medicale INSERM

The present disclosure provides methods of treating liver cancer and preventing liver cancer recurrence with anti-progastrin antibodies, methods of monitoring treatment efficacy of anti-progastrin therapy for liver cancer, and compositions useful therefore.

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Номер записи: 28
26-01-2012 дата публикации

Antibodies against fatty acid synthase

Номер: US20120020978A1
Автор: Patrick J. Muraca
Принадлежит: Nuclea Biotechnologies Inc

The present invention relates to antibodies that immunospecifically bind to FAS and certain FAS related proteins. The invention encompasses human and humanized forms of the antibodies and their use in treating cancers and other proliferative disorders. The invention also relates to FAS-derived peptides useful for preparing the antibodies. Methods and compositions for detecting, diagnosing, treating or ameliorating a disease or disorder, especially cancer and other proliferative disorders using the present antibodies also are disclosed.

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Номер записи: 29
26-01-2012 дата публикации

Methods and Devices for Rapid Urine Concentration

Номер: US20120021407A1
Автор: Yousef Haj-Ahmad
Принадлежит: Norgen Biotek Corp

The present invention provides a device for the concentration of one or more target analytes contained in a urine sample. The device comprises a tube comprising an upper portion defining an opening for receiving the urine sample and a lower tapered portion terminating in collection reservoir. The tube contains a predetermined amount of a particulate binding agent which specifically binds the one or more target analytes and of a predetermined amount of a binding buffer. The device comprises means for seating the opening of the tube. The present invention further provides methods and kits for concentrating one or more target analytes in murine sample.

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Номер записи: 30
26-01-2012 дата публикации

DOPAMINERGIC NEURON PROLIFERATIVE PROGENITOR CELL MARKER Nato3

Номер: US20120021417A1
Автор: Tomoya Nakatani, Yasuko Nakagawa, Yoshimasa Sakamoto, Yuichi Ono
Принадлежит: Eisai R&D Management Co Ltd

The present invention is a probe, a primer, and an antibody, for detecting a dopaminergic neuron proliferative progenitor cell. According to the present invention, there is provided a polynucleotide probe and a polynucleotide primer for use in the detection or selection of a dopaminergic neuron proliferative progenitor cell, which can hybridize with a polynucleotide consisting of a nucleotide sequence of a Nato3 gene, or a complementary sequence thereto, and an antibody against a Nato3 protein, or a part thereof for use in the detection or selection of a dopaminergic neuron proliferative progenitor cell.

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Номер записи: 31
26-01-2012 дата публикации

Sensor for fast detection of e-coli

Номер: US20120021502A1
Автор: Pravansu S. Mohanty, Ramesh K. Guduru
Принадлежит: MRIDANGAM RES INTELLECTUAL PROPERTY TRUST

A method of fabricating biochip sensor comprising providing a precursor; depositing the precursor on a substrate to form a coating; and rapid melting/quenching treatment of the coating with an energy source to form micro/nanotextured surface with enhanced reflectance for fast chemiluminescence response of E - Coli bacteria.

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Номер записи: 32
26-01-2012 дата публикации

Optics collection and detection system and method

Номер: US20120021525A1
Автор: Adrian Fehr, Nathaniel Joseph McCaffrey, Stephen Turner
Принадлежит: Pacific Biosciences of California Inc

Optics collection and detection systems are provided for measuring optical signals from an array of optical sources over time. Methods of using the optics collection and detection systems are also described.

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Номер записи: 33
26-01-2012 дата публикации

Diagnostic assays for prostate cancer using psp94 and psa biomarkers

Номер: US20120021925A1
Автор: Douglas Barker, Katrin Atnikov, Stephen Frost, Yilan Zhang
Принадлежит: Miraculins Inc

The application refers to a method for diagnosing prostate cancer through the measurement of the combination of PSP94 (β-microseminoprotein) and F/T PSA biomarkers, the method using urine samples to measure PSP94 and serum samples to analyse F/T PSA. In one embodiment, the PSP94 is standardized to creatinine. Also based on the measurement of PSP94 and F/T PSA are provided methods and kits for (a) diagnosing aggressive prostate cancer; (b) differential diagnosis; and (c) diagnosing the progression of prostate cancer.

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Номер записи: 34
26-01-2012 дата публикации

Fluorescence resonance energy transfer assays for sarco/endoplasmic reticulum calcium atpase and phospholamban

Номер: US20120021926A1
Автор: David D. Thomas, Krisztina M. Zsebo, Razvan L. Cornea
Принадлежит: Individual

Provided herein are methods for identifying molecules capable of modulating SERCA, the SERCA-PLB complex or the microenvironment of the complex. An exemplary assay provided herein is fluorescence resonance energy transfer (FRET). Also provided herein are FRET assays that are optimized for high-throughput screening (HTS) for identifying small molecules that modulate SERCA or the SERCA-PLB complex. Further provided are kits for carrying out said methods for identifying molecules.

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Номер записи: 35
26-01-2012 дата публикации

Use of fccs for the analysis of interaction parameters in an in vivo-like environment

Номер: US20120021942A1
Автор: Frank Becker, Kerrin Hansen, Stefan Hannus
Принадлежит: INTANA BIOSCIENCE GMBH

The present invention relates to the determination of interaction parameters of at least two analytes in cellular lysates, wherein at least one competitive agent is optionally further present.

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Номер записи: 36
02-02-2012 дата публикации

Formation and encapsulation of molecular bilayer and monolayer membranes

Номер: US20120025414A1
Автор: Jacob J. Schmidt, Jason Poulos, Noah Malmstadt, Tae-Joon Jeon
Принадлежит: UNIVERSITY OF CALIFORNIA

Disclosed herein are compositions, methods, and devices related to bilayer and monolayer membranes, their encapsulation in a hydrogel, and their formation. Methods of using the disclosed compositions and devices are also disclosed.

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Номер записи: 37
02-02-2012 дата публикации

Contrast agent for photoacoustic imaging and photoacoustic imaging method using the same

Номер: US20120027679A1
Автор: Fumio Yamauchi, Kengo Kanazaki, Masato Minami, Mayuko Kishi, Sachiko Inoue, Satoshi Ogawa, Tatsuki Fukui
Принадлежит: Canon Inc

It is intended to provide a novel contrast agent for photoacoustic imaging that is highly capable of binding to a target molecule and generates high photoacoustic signals. The present invention provides a contrast agent for photoacoustic imaging represented by Formula 1: MNP−((L) l −(P) m ) n   (Formula 1) (wherein MNP represents a particle containing an iron oxide particle; L represents a linker molecule; P represents a ligand molecule; l represents 0 or 1; and m and n represent an integer of 1 or larger), the contrast agent for photoacoustic imaging including: a particle containing an iron oxide particle that absorbs light in a near-infrared region; and at least one or more ligand molecule(s) immobilized on the particle containing an iron oxide particle, wherein the immobilization density of the ligand molecule is equal to or higher than the cell surface density of a target molecule.

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Номер записи: 38
02-02-2012 дата публикации

Hk1-binding proteins

Номер: US20120027686A1
Автор: Andrew Nixon, Anthony Williams, Daniel J. Sexton, Qi-Long Wu, Robert C. Ladner
Принадлежит: Dyax Corp

The invention features hK1 binding polypeptides as well as compositions comprising such polypeptides and methods of making and using such polypeptides.

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Номер записи: 39
02-02-2012 дата публикации

Method and compositions for cancer prognosis

Номер: US20120027750A1
Автор: Guillaume Cartron, Hervé WATIER
Принадлежит: Centre Hospitalier Regional Universitaire De Tours, UNIVERSITE FRANCOIS RABELAIS DE TOURS

Methods are provided to determine the cancer prognosis of subjects and/or to adapt the treatment protocol of subjects having or susceptible to cancer. Embodiments include the steps of determining in vitro the genotype of said subject at a polymorphism in the C3-ITGAM axis, making a cancer prognosis of the subject based on said genotype and selecting an anti-cancer treatment for the subject.

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Номер записи: 40
02-02-2012 дата публикации

Compositions and methods for treating or preventing inflammatory bowel disease and colon cancer

Номер: US20120027799A1
Автор: Cynthia L. Sears, Drew M. Pardoll, Franck Housseau, Shaoguang Wu
Принадлежит: JOHNS HOPKINS UNIVERSITY

The invention provides compositions and methods for useful for the diagnosis of inflammatory bowel disease, ETBF-induced colitis, colonic hyperplasia and/or colon carcinogenesis in a subject in biological samples (e.g., stool, urine, blood, serum, tissue). The invention further provides compositions and methods for the treatment or prevention of colitis, colon cancer, or inflammatory bowel disease (e.g., Crohn's disease).

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Номер записи: 41
02-02-2012 дата публикации

Cell lines expressing guanylate cyclase-c and methods of using them

Номер: US20120028278A1
Автор: Jessica Langer, Kambiz Shekdar
Принадлежит: Chromocell Corp

Cell lines that stably express GC-C and methods for using those cell lines are disclosed herein. The invention includes cell lines that express GC-C and techniques for creating cell lines. The GC-C-expressing cell lines are highly sensitive, physiologically relevant and produce consistent results in cell-based assays, e.g., high throughput screening assays.

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Номер записи: 42
02-02-2012 дата публикации

Whitefly Ecdysone Receptor Nucleic Acids, Polypeptides, and Uses Thereof

Номер: US20120028300A1
Автор: Dean Ervin Cress, Jianzhong Zhang, Subba Reddy Palli, Tarlochan Singh Dhadialla
Принадлежит: Intrexon Corp

The present invention relates to a novel isolated whitefly ecdysone receptor polypeptide. The invention also relates to an isolated nucleic acid encoding the whitefly ecdysone receptor polypeptide, to vectors comprising them and to their uses, in particular in methods for modulating gene expression in an ecdysone receptor-based gene expression modulation system and methods for identifying molecules that modulate whitefly ecdysone receptor activity.

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Номер записи: 43
02-02-2012 дата публикации

pH MODULATION METHOD TO DETECT LIGAND-RECEPTOR BINDING

Номер: US20120028823A1
Автор: Aaron D. Robison, Hyunsook Jung, Paul S. Cremer
Принадлежит: TEXAS A&M UNIVERSITY SYSTEM

The present disclosure relates to detecting receptor-ligand binding by measuring local pH modulation using a pH-sensitive fluorophore.

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Номер записи: 44
02-02-2012 дата публикации

Highly sensitive detection method for highly virulent oral cavity bacteria

Номер: US20120028879A1
Автор: Kazuhiko Nakano, Kazuo Umemura, Kazuya Hokamura, Koichiro Wada, Ryota Nomura, Takashi Ooshima
Принадлежит: Hamamatsu University School of Medicine NUC

Provided is a method that involves the detection of protein antigen (PA) and/or collagen-binding protein (CBP) of oral cavity bacteria in a sample, and in which oral cavity bacteria that exacerbate hemolysis are detected for and/or subjects at high-risk for hemolysis aggravation are screened anchor the level of risk of the hemolysis aggravation in a subject is assessed if a PA is not detected anchor a CBP is detected in the sample. Also provided are a detection reagent and kit for use in the method.

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Номер записи: 45
02-02-2012 дата публикации

Biomarker assays for detecting or measuring inhibition of tor kinase activity

Номер: US20120028972A1
Автор: Jian-hua DING, Lilly Wong, Shuichan Xu
Принадлежит: Signal Pharmaceuticals LLC

Provided herein are methods for detecting and/or measuring the inhibition of TOR kinase activity in a subject and uses associated therewith.

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Номер записи: 46
02-02-2012 дата публикации

Posterior segment drug delivery

Номер: US20120029470A1
Автор: Cary J. Reich, Douglas Sutton, Eugene de Juan, Jr., Hanson S. Gifford, Iii, K. Angela Macfarlane, Kathleen Cogan Farinas, Michael Barrett, Randolph E. Campbell, Yair Alster
Принадлежит: ForSight Vision4 Inc

A therapeutic device to release a therapeutic agent comprises a porous structure coupled to a container comprising a reservoir. The reservoir comprises a volume sized to release therapeutic amounts of the therapeutic agent for an extended time when coupled to the porous structure and implanted in the patient. The porous structure may comprise a first side coupled to the reservoir and a second side to couple to the patient to release the therapeutic agent. A plurality of interconnecting channels can extend from the first side to the second side so as to connect a first a plurality of openings on the first side with a second plurality of openings on the second side.

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Номер записи: 47
09-02-2012 дата публикации

Analysis method, sample analysis tool, method for preventing back-flow of sample solution, and method for preventing increase in background

Номер: US20120031206A1
Автор: Kazuhiro Ohmiya
Принадлежит: Arkray Inc

Provided is an analysis method in which increase in a background can be prevented in a simple manner without cost. The analysis method of the present invention is carried out using a sample analysis tool 10 including a development member 11 in which a developing solution supply portion 12, a sample supply portion 13, and a detection portion 14 in which a substance 17 that specifically binds to an analyte 16 in a sample is immobilized are provided in this order from upstream to downstream along the flow of a developing solution. A sample solution is supplied to the sample supply portion 13, and a developing solution is supplied to the developing solution supply portion 12 simultaneously with the supply of the sample solution or prior to the supply of the sample solution. By the development of the developing solution in the development member 11 in the presence of a labeled specifically binding substance 15, the sample solution is introduced to the detection portion 14. In the detection portion 14, a complex 18 of the immobilized specifically binding substance 17, the analyte 16, and the labeled specifically binding substance 15 is formed. The analyte 16 is analyzed by detecting a label 19 in the complex 18.

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Номер записи: 48
09-02-2012 дата публикации

Tyrosine kinase receptor tyro3 as a therapeutic target in the treatment of cancer

Номер: US20120034167A1
Автор: François RADVANYI, Isabelle Bernard-Pierrot, Nicolas Stransky, Yves Allory
Принадлежит: Assistance Publique Hopitaux de Paris APHP, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS, INSTITUT CURIE, Universite Paris Est Creteil Paris 12

The present invention concerns new methods for treating cancer by using TYRO3 inhibitors and methods for identifying new molecules of interest for treating cancer.

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Номер записи: 49
09-02-2012 дата публикации

Marker for Liver-Cancer Diagnosis and Recurrence and Survival Prediction, a Kit Comprising the Same, and Prognosis Prediction in Liver-Cancer Patients Using the Marker

Номер: US20120034235A1
Автор: Chul Ju Han, Dong Hyoung Lee, Eun Ju LEE, Eun Ran Park, Hyun Jin Shin, Kee Ho Lee, Myoung Jin Park, Pu Hyeon Cha, Sang Bum Kim, Sang Gu Hwang, Seon Rang Woo, Sun Hoo Park, Yong Ho Ham
Принадлежит: Korea Institute of Radiological and Medical Sciences

A composition for detecting a marker for the diagnosis or prognosis of liver cancer is disclosed. The composition includes an agent capable of assessing the expression level of UQCRH (ubiquinol-cytochrome c reductase hinge protein). In addition, a kit having the composition, a microarray for the diagnosis of liver cancer using the marker, and a method for detecting the marker, and predicting recurrence following surgery in liver cancer patients are disclosed. The marker is able to contribute to the early diagnosis of liver cancer and prediction of recurrence following surgery and survival of liver cancer patients who have undergone hepatic resection, and also is significant for being a promising therapeutic target for liver cancer.

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Номер записи: 50
09-02-2012 дата публикации

Diagnosis of benign and cancerous growths by measuring circulation tumor stem cells and serum annexina2

Номер: US20120034627A1
Автор: Pomila Singh
Принадлежит: University of Texas System

Provided herein is a method for diagnosing/prognosing a metastatic cancer in a subject by measuring and detecting one or more of CS-ANXA2, DCAMKL, Lgr5 or CS-ANAX2 and DCAMKL or CS-ANXA2 and Lgr5 positive circulating tumor stem cells in the subject's blood or plasma. Also provided is a method for distinguishing the presence of early stage primary cancer from advanced stage metastatic cancer in the subject by measuring and detecting AnnexinA2, CS-ANXA2 and DCAMKL−1 or Lgr5 in the blood or plasma. In addition, there is provided a method for distinguishing the presence of benign, pre-cancerous tumorous growths or cancerous tumors in the subject by measuring and detecting AnnexinA2 and circulating tumor stem cells positive for CS-ANXA2 and DCAMKL or CS-ANXA2 and Lgr5 in the blood or plasma.

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Номер записи: 51
09-02-2012 дата публикации

Method for obtaining a singular cell model capable of reproducing in vitro the metabolic idiosyncrasy of humans

Номер: US20120034642A1
Автор: Agustín Lahoz Rodríguez, José Vicente Castell Ripoll, María José Gómez-Lechón, Ramiro Jover Atienza
Принадлежит: Advancell Advanced In Vitro Cell Technologies SA

The method is based on the use of expression vectors coding for the sense and anti-sense mRNA of the Phase I and Phase II drug biotransformation enzymes showing a greatest variability in humans for transforming cells expressing reductase activity. Such vectors can modulate (increase or decrease) the individualized expression of an enzyme without affecting the other enzymes. This singular cell model can reproduce in vitro the metabolic idiosyncrasy of humans. It is applicable in the study of development of new drugs, specifically in the study of metabolism, potential idiosyncratic hepatotoxicity, medicament interactions, etc., of new drugs.

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Номер записи: 52
09-02-2012 дата публикации

Methods for forming dyed microspheres and populations of dyed microspheres

Номер: US20120035328A1
Автор: Ananda G. Lugade, Ewald Terpetschnig, Kurt D. Hoffacker
Принадлежит: Individual

Various methods for forming dyed microspheres are provided. One method includes activating a chemical structure coupled to a dye using heat or light to form a reaction intermediate in the presence of a microsphere. The reaction intermediate covalently attaches to a polymer of the microsphere thereby coupling the dye to the polymer and forming the dyed microsphere. Additional methods are provided for forming a dyed microsphere coupled to a molecule. These methods include dyeing the microspheres as described above in addition to synthesizing the molecule on an outer surface of the dyed microspheres. A population of dyed microspheres is also provided. Each of the dyed microspheres of the population includes a dye attached to a polymer of each of the dyed microspheres by a chemical structure. A coefficient of variation in dye characteristics of the population of dyed microspheres attributable to the dye is less than about 10%.

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Номер записи: 53
09-02-2012 дата публикации

Prostate cancer cell lines and their use in screening method

Номер: US20120036587A1
Автор: Anne Chauchereau, Catherine Gaudin, Jean Benard, Karim Fizazi, Nader Al Nakouzi
Принадлежит: Institut Gustave Roussy (IGR)

The present invention relates to a prostate cancer cell line CNCM deposit number I-4126, the use thereof for preparing resistant prostate cancer cell lines, the resistant prostate cancer cell lines, and the use of these prostate cancer cell lines for screening compounds of interest.

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Номер записи: 54
16-02-2012 дата публикации

Anti-Hemagglutinin Antibody Compositions And Methods Of Use Thereof

Номер: US20120039899A1
Автор: Andres G. Grandea, III, Christina L. Boozer, Ole Olsen
Принадлежит: Theraclone Sciences Inc

The present invention provides novel human anti-Influenza antibodies and related compositions and methods. These antibodies are used in the prevention, inhibition, neutralization, diagnosis, and treatment of influenza infection.

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Номер записи: 55
16-02-2012 дата публикации

Glioblastoma multiforme-reactive antibodies and methods of use thereof

Номер: US20120039915A1
Автор: Bin Liu, James D. Marks, Scott Bidlingmaier, Xiaodong Zhu
Принадлежит: UNIVERSITY OF CALIFORNIA

The present disclosure is generally related to antibodies that bind specifically to glioblastoma multiforme (GBM) cells. In particular, the present disclosure provides compositions comprising human single chain or full-length antibodies that bind tumor cells. Additionally the present disclosure provides methods of using the anti-GBM antibodies.

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Номер записи: 56
16-02-2012 дата публикации

Identification of Porcine Reproductive and Respiratory Syndrome Virus

Номер: US20120040335A1
Автор: Craig Welbon, Elizabeth M. Brown, Eric A. Nelson, Ying Fang
Принадлежит: South Dakota State University

An enzyme-linked immunosorbent assay (ELISA) is based on the non-structural protein 7 (nsp7) of porcine reproductive and respiratory syndrome virus (PRRSV) and provides for the simultaneous detection and differentiation of serum antibodies directed against Type 1 (European) and Type 2 (North American) PRRSV. The invention provides a serological assay for the detection and/or differentiation of serum antibodies directed against Type 1 and/or Type 2 PRRSV utilizing PRRSV nsp7 as an antigen, and provides a diagnostic method for the detection of PRRSV infection, epidemiological surveys, and outbreak investigations. The invention may be used either alone or as a follow-up assay to determine the true status of unexpected positive results that may occur using other assays, such as the IDEXX HERDCHEK PRRS ELISA.

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Номер записи: 57
16-02-2012 дата публикации

Lateral Flow Assays for Non-Diagnostic Analytes

Номер: US20120040336A1
Автор: Dwayne Bisgrove, Hiroaki Sagawa
Принадлежит: Clontech Laboratories Inc

Methods of determining whether a non-diagnostic analyte is present in a non-diagnostic sample are provided. Aspects of the methods include applying a non-diagnostic sample to a sample receiving region of a lateral flow assay device and reading a detection region to determine whether a non-diagnostic analyte is present in the non-diagnostic sample. Also provided are kits that find use in practicing methods of the invention.

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Номер записи: 58
16-02-2012 дата публикации

Conformational Epitope Initiated Signal Amplification

Номер: US20120040337A1
Автор: John T. Unger, Rolf Hilfiker
Принадлежит: Individual

This invention relates to a method to generate a signal used to detect the presence or quantity of a biomarker in a sample. The signal generating reaction is initiated when the biomarker under assay interacts with a specific binding partner. The interaction produces a structural change in the binding partner that is recognized by additional binding partners capable of generating a signal. The reaction produces a localized cluster of signaling molecules that can be detected above background. The signaling cluster is detectable within minutes when interrogated in a chamber of specific dimensions. The presence of the signaling clusters is a qualitative indication of the presence of the analyte, while the number of signaling clusters detected is a direct quantification of the number of biomarker molecules in the sample. The reaction can be formatted to detect proteins, nucleic acids, cells or other informative biomarkers.

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Номер записи: 59
16-02-2012 дата публикации

RBM3 in Testicular Cancer Diagnostics and Prognostics

Номер: US20120040338A1
Автор: Jakob Eberhard, Karin Jirstrom
Принадлежит: Atlas Antibodies AB

The present disclosure provides a method for determining whether a mammalian subject belongs to a first or a second group, wherein subjects of the first group have a higher risk of having a testicular disorder than subjects of the second group, comprising the steps of: evaluating an amount of RBM3 protein or RBM3 mRNA in at least part of an earlier obtained sample comprising biological material from a testicle of said subject and determining a sample value corresponding to the evaluated amount; comparing said sample value with a predetermined reference value; and if said sample value is higher than said reference value, concluding that the subject belongs to the first group; and if said sample value is lower than or equal to said reference value, concluding that the subject belongs to the second group. Further, a prognostic method for testicular cancer is provided, as well as means and uses with prognostic and diagnostic applications.

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Номер записи: 60
16-02-2012 дата публикации

Methods of classifying the severity of diseases or disorders

Номер: US20120040354A1
Автор: Borge Gronne Nordestgaard, Hans Jorgen Nielsen, Ib Jarle Christensen, Julia Sidenius Johansen, Stig Bojesen
Принадлежит: Herlev Hospital Region Hovedstaden, HVIDOVRE HOSPITAL, RIGSHOSPITALET

The present invention relates to methods of classifying the severity of a non-specific disease or disorder in a subject, wherein a determined level of YKL-40 is compared to one or more reference levels of YKL-40, and the severity of said non-specific disease or disorder is deduced from said comparison. The present invention furthermore relates to a method of classifying the severity of a disease or disorder in a subject, wherein a determined level of YKL-40 is compared to one or more previously determined levels of YKL-40 from the same subject. In both methods, the subject may suffer from a variety of diseases or disorders. In addition the present invention relates to a kit and a device that may be used in the methods of the present invention comprising means for measuring the level of YKL-40 in a sample; and means for comparing the measured level of YKL-40 with one or more reference levels of YKL-40.

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Номер записи: 61
16-02-2012 дата публикации

Lung cancer diagnostic polypeptide, method for detecting lung cancer, and method for evaluating therapeutic effect

Номер: US20120040376A1
Автор: Atsuhiko Toyama, Hidewaki Nakagawa, Koji Ueda, Taka-Aki Sato
Принадлежит: RIKEN Institute of Physical and Chemical Research, Shimadzu Corp

A novel biomarker for use in lung cancer diagnosis is provided.

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Номер записи: 62
16-02-2012 дата публикации

Method for Introducing Protein and/or Peptide Into Cell

Номер: US20120040390A1
Автор: Hidenori Yamada, Hidetaka Nakanishi, Junichiro Futami, Takashi Kai
Принадлежит: NIPPON SHOKUBAI CO LTD

The present invention provides a method of intracellular introduction by which a protein and/or peptide can be efficiently introduced into living cells and which makes it possible to effectively analyze the behavior and function of the protein and/or peptide introduced and can be suitably utilized/applied, for example in the technology “live cell imaging” which realizes the immunohistochemical visualization in living cells under physiological conditions. The method of intracellular introduction is a method for introducing a protein and/or peptide into a cell, which comprises the process of introducing a conjugate generated by binding of a compound adsorbable on a cell surface to a protein and/or peptide via a polysulfide bond into a cell and treating with a reducing agent.

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Номер записи: 63
16-02-2012 дата публикации

Target substance detection method using aptamer

Номер: US20120040865A1
Автор: So Youn Kim
Принадлежит: Industry Academic Cooperation Foundation of Dongguk University

The present invention relates to a method and kit of detecting a target material using an aptamer, and more particularly to a method and kit for detecting a target material, in which a sample and a second aptamer are added to a first aptamer immobilized on a solid phase so as to form a bond sandwiched between the first aptamer, the target material and the second aptamer, to an FET sensor-based method and kit for detecting a target material, and to an AAO sensor-based method and kit for detecting a target material. The inventive method for a target material using an aptamer can detect even low-molecular-weight materials which were difficult to detect in the prior art, thereby enabling detection of disease-related metabolites, environmental pollutants and food toxins in solutions. In addition, the detection method of the present invention is a direct and simple method and is highly cost-effective, because it uses the aptamer which can be consistently reproduced and can be produced at low costs. Thus, the present invention is very useful.

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Номер записи: 64
23-02-2012 дата публикации

Human monoclonal antibodies to ctla-4

Номер: US20120045442A1
Автор: C. Geoffrey Davis, Douglas Charles Hanson, Eileen Elliott Mueller, Jeffrey Herbert Hanke, Jose Ramon Corvalan, Mark Joseph Neveu, Steven Christopher Gilman
Принадлежит: Abgenix Inc, PFIZER INC

In accordance with the present invention, there are provided fully human monoclonal antibodies against human cytotoxic T-lymphocyte antigen 4 (CTLA-4). Nucelotide sequences encoding and amino acid sequences comprising heavy and light chain immunoglobulin molecules, particularly contiguous heavy and light chain sequences spanning the complementarity determining regions (CDRs), specifically from within FR1 and/or CDR1 through CDR3 and/or within FR4, are provided. Further provided are antibodies having similar binding properties and antibodies (or other antagonists) having similar functionality as antibodies disclosed herein.

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Номер записи: 65
23-02-2012 дата публикации

Method for diagnosing endometriosis and diagnostic kit for endometriosis

Номер: US20120045779A1
Автор: Masaharu Ito, Motowo Nabeta, Yasuhito Abe
Принадлежит: Mochida Pharmaceutical Co Ltd

It is an object of the present invention to provide: a method for determining endometriosis, in which a blood sample from a subject can be used, and which is capable of determining endometriosis with higher sensitivity and higher precision than those of a conventional method using only a conventional endometriosis marker such as CA125; and a diagnostic kit for carrying out the method of the present invention. The method for determining endometriosis according to the present invention comprises: a step of analyzing an expression of at least one selected from among an anti-syntaxin autoantibody, an anti-PDIK1L autoantibody and an anti-enolase autoantibody; and a step of determining the presence or absence of the onset of endometriosis based on results of said expression analysis.

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Номер записи: 66
23-02-2012 дата публикации

Multipotent neural stem cells

Номер: US20120045832A1
Автор: Bruce Trapp, Robert Miller
Принадлежит: Individual

An isolated multipotent neural stem cells has a phenotype identified by expression of the protein β-tubulin IV and Olig2 and the absence of the proteins NG2, PLP, and GFAP.

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Номер записи: 67
23-02-2012 дата публикации

Portable device based on immobilized cells for the detection of analytes

Номер: US20120045835A1
Автор: Aldo Roda, Elisa Michelini, Laura Mezzanotte, Luca Cevenini, Luisa Stella Dolci
Принадлежит: Universita di Bologna

The present invention relates to a portable device for the detection of analytes, in particular toxic substances, comprising at least a whole-cell biosensor with cells immobilized onto a transparent and inert matrix that allows the maintenance of cell vitality. The matrix comprises a mixture of collagen and/or its enzyme degradation derivatives, a proteoglycan and a mixture of vinyl polymer and an optionally modified polysiloxane, and an orthosilicate. The biosensor can be a genetically modified cell that expresses luciferase as reporter gene.

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Номер записи: 68
23-02-2012 дата публикации

Releasable nonvolatile mass-label molecules

Номер: US20120046180A1
Автор: Christopher H. Becker, Daniel J. Pollart, Joseph A. Monforte, Thomas A. Shaler
Принадлежит: Sequenom Inc

Releasable tag reagents for use in the detection and analysis of target molecules, particular in mass spectrometric analyses are provided. Also provided are methods of detection that employ releasable tag reagents.

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Номер записи: 69
23-02-2012 дата публикации

Automated detection and counting of biomolecules using nanoparticle probes

Номер: US20120046191A1
Автор: Benjamin K. Scholl, Brian R. Long, Tania Q. Vu
Принадлежит: Oregon Health Science University

An apparatus and method for counting nanoparticle probes is disclosed. In one embodiment, quantum dot-tagged proteins on optically transparent membranes or slides are counted. The transparent membranes or slides are loaded onto a stage (e.g., an X-Y stage or X-Y-Z stage), which can automatically reposition the transparent membrane or slides for image capture at varying locations. A microscope can be used for providing a light source to fluoresce the nanocrystals and for providing the magnification needed for image capture. Once one or more images are captured, the nanoparticles can be automatically counted using post-processing software that maintains a total count across multiple images, if desired.

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Номер записи: 70
23-02-2012 дата публикации

Detecting bcl-b expression in cancer and uses thereof

Номер: US20120046195A1
Автор: John C. Reed, Maryla Krajewska
Принадлежит: SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

Provided herein are compositions and methods of detecting Bcl-B expression in cancer cells to prognose, monitor, or select therapies for cancers such as breast cancer, prostate cancer, lung cancer, or gastric cancer.

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Номер записи: 71
23-02-2012 дата публикации

ANTI-lgSF4 ANTIBODY AND UTILIZATION OF THE SAME

Номер: US20120046451A1
Автор: Akihiko Takasaki, Atsushi Sugioka, Chiho Muramatsu, Gene Kurosawa, Kazuhiro Morishita, Kazuhiro Suzuki, Kazuki Matsuda, Keiko Ogawa, Mariko Sumitomo, Masachika Azuma, Miwa Morita, Nobuhiro Hayashi, Nobuhiro Takahashi, Sari Fujiyama, Susumu Tsutsumi, Yasushi Akahori, Yoshikazu Kurosawa, Yoshinori Ukai, Yoshitaka Iba
Принадлежит: Institute for Antibodies Co Ltd

It is intended to clarify a molecule which is available as a target in treating or diagnosing cancer and utilize the molecule in the medical field or the research field. By treating IgSF4, which has been identified as a molecule specifically expressed in lung cancer cells, with an antibody, and ADCC activity is exerted. Based on this finding, an anti-IgSF4 antibody is provided as a means efficacious in treating cancer, etc.

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Номер записи: 72
01-03-2012 дата публикации

Markers and methods for assessing and treating lupus patients susceptible to photoprovocation

Номер: US20120052066A1
Автор: Cesar Calderon, John Getsy
Принадлежит: Centocor Inc

A method for predicting or detecting susceptibility to lupus of an individual subjected to photoprovocation obtains biological samples from the individual before and after exposure to photoprovocation and compares the levels of at least a portion of members of a 45-member panel or subset thereof to determine whether the individual is susceptible to lupus. The method enables identification of potential lupus patients prior to onset of disease symptoms.

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Номер записи: 73
01-03-2012 дата публикации

Compositions, Kits, and Methods for Predicting Anti-Cancer Response to Anthracyclines

Номер: US20120052079A1
Автор: Andrea L. Richardson, Zhigang C. Wang
Принадлежит: Dana Farber Cancer Institute Inc

The present invention is based, in part, on the discovery that amplification of human chromosome 8q22-23 regions and over-expression of 8q22-23 genes (e.g., LAPTM4B and YWHAZ) is associated with and predictive of resistance to anthracycline-type chemotherapy. Accordingly, the invention relates to compositions, kits, and methods for predicting the response of cancer cells, e.g., breast, prostate, lung, ovarian, pancreatic, liver, and colon malignancies to anthracyclines.

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Номер записи: 74
01-03-2012 дата публикации

Methods of diagnosing cervical cancer

Номер: US20120052484A1
Автор: Chamorro Somoza Diaz-Sarmiento, Johannes Schweizer, Michael P. Belmares, Peter S. Lu
Принадлежит: Individual

The invention provides reagents and methods for detecting pathogen infections in human samples. This detection utilizes specific proteins to detect the presence of pathogen proteins or abnormal expression of human proteins resulting from pathogen infections. Specific methods, compositions and kits are disclosed herein for the detection of oncogenic Human papillomavirus E6 proteins in clinical samples.

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Номер записи: 75
01-03-2012 дата публикации

Photodamage mitigation compounds and systems

Номер: US20120052488A1
Автор: Andrei Fedorov, John Lyle, Robert Weber, Stephen Yue, Xiangxu Kong
Принадлежит: Pacific Biosciences of California Inc

Compositions, devices, systems and methods for reducing and/or preventing photo-induced damage of one or more reactants in an illuminated analytical reaction by addition of one or more photoprotective compounds to the reaction mixture and allowing the reaction to proceed for a period that is less than a photo-induced damage threshold period.

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Номер записи: 76
01-03-2012 дата публикации

Methods and systems for monitoring reactions

Номер: US20120052490A1
Автор: John Eid, Stephen Turner
Принадлежит: Pacific Biosciences of California Inc

Methods and systems for monitoring reactions by observing signals deriving from those reactions, using signal processing that allows differentiation between signals that are otherwise optically overlapping by conventional detection methods. Centroid determination is used to identify signal sources that are presenting confounding overlapping signals due to their physical proximity, and/or to identify discrete signals from different reaction centers.

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Номер записи: 77
01-03-2012 дата публикации

Cyanine dyes

Номер: US20120052506A1
Автор: David Sun, Gene Shen, Stephen Yue
Принадлежит: Pacific Biosciences of California Inc

The invention provides a novel class of cyanine dyes that are functionalized with sulfonic acid groups and a linker moiety that facilitates their conjugation to other species and substituent groups which increase the water-solubility, and optimize the optical properties of the dyes. Also provided are conjugates of the dyes, methods of using the dyes and their conjugates and kits including the dyes and their conjugates.

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Номер записи: 78
01-03-2012 дата публикации

Phospholinked dye analogs with an amino acid linker

Номер: US20120052507A1
Автор: Gene Shen
Принадлежит: Pacific Biosciences of California Inc

In various embodiments, the present invention provides fluorescent dyes that are linked to another species through an amino acid or peptide linker. In an exemplary embodiment, the dye is linked to a polyphosphate nucleic acid through an amino acid or peptide linker. These conjugates find use in single molecule DNA sequencing and other applications. In various embodiments, the dye moiety is a cyanine dye. Cyanine dyes that are highly charged, such as those including muliple sulfonate, alkylsulfonate, carboxylate and/or alkylcarboxylate moieties are examples of cyanine dyes of use in the compounds of the invention.

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Номер записи: 79
01-03-2012 дата публикации

Cell evaluation system using cell sheet and method for using the system

Номер: US20120052524A1
Автор: Atsuhiro Saito, Masahiro Kinooka, Masahito Taya, Tatsuya Shimizu, Teruo Okano, Yasunori Takezawa, Yoshiki Sawa
Принадлежит: TOKYO WOMENS MEDICAL UNIVERSITY

Three-dimensional information on a biological parameter relating to at least one selected from viability, proliferating ability, migration, and differentiation of cultured cells can be obtained by a simple two-dimensional analytical technique by constructing a cell evaluation system including a multilayered cell sheet, target cells, and a two-dimensional analyzer.

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Номер записи: 80
01-03-2012 дата публикации

Reagent kit for detecting lupus anticoagulant and method of determining presence or absence of lupus anticoagulant

Номер: US20120052585A1
Автор: Kazuyo Yoshida, Masahiro Okuda, Osamu Kumano
Принадлежит: Sysmex Corp

The present invention provides a reagent kit for detecting LA which includes a first clotting time-measuring reagent containing manganese salt and a second clotting time-measuring reagent which contains manganese salt at a concentration lower than that of the first clotting time-measuring reagent or does not contain manganese salt and a method of determining the presence or absence of LA using the kit.

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Номер записи: 81
01-03-2012 дата публикации

Biomaterial construct, its producing method, biomaterial support, target material purifying method, affinity chromatography container, separation chip, analyzing method and analyzing separator for target material, biomaterial complex, and its support, sensor chip, solid support with biomaterial fixed thereon

Номер: US20120053078A1
Автор: Hiroyuki Tanaka, Hisao Takeuchi, Minako Hanasaki, Tatsushi Isojima, Toshifumi Shiroya, Yasuo Ifuku
Принадлежит: Mitsubishi Chemical Corp

A biomaterial structure containing a larger amount of biomaterial than the conventional art with maintaining the reactivity of the biomaterial is provided by linking particulate lumps in which the biomaterial is bound with a compound capable of binding to the biomaterial, wherein the particle diameter of the particulate lumps is 10 μm or smaller.

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Номер записи: 82
08-03-2012 дата публикации

Anti- integrin antibodies, compositions, methods and uses

Номер: US20120058128A1
Автор: Jill Giles-Komar, Linda Snyder, Marian T. Nakada, Mohit Trikha
Принадлежит: Janssen Biotech Inc

The present invention relates to at least one novel anti-alpha-V subunit antibodies, including isolated nucleic acids that encode at least one anti-alpha-V subunit antibody, alpha-V subunit, vectors, host cells, transgenic animals or plants, and methods of making and using thereof, including therapeutic compositions, methods and devices.

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Номер записи: 83
08-03-2012 дата публикации

Use of over expression of cystathionine gamma lyase as a prognostic, diagnostic and therapeutic target for cancer

Номер: US20120058204A1
Автор: Kazufumi Honda, Tesshi Yamada, Wilber Huang
Принадлежит: ABNOVA CORP, National Cancer Center Research Institute

The present invention relates to a method of identifying an expression level of cystathionine gamma lyase (CTH) in a sample from a subject. The present invention further discloses a method of diagnosing a subject with cancer having risk of resistance to a platinum-based drug. The present invention also discloses a method for improving efficacy of a platinum-based drug in a subject suffering a cancer.

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Номер записи: 84
08-03-2012 дата публикации

Differential immunoassay for prrs vaccine antibody

Номер: US20120058466A1
Автор: Kyoung-Jin Yoon, Wai-Hong Wu
Принадлежит: Iowa State University Research Foundation ISURF

The present invention relates to immunoassays for serologically differentiating animals naturally infected with PRRS virus from animals vaccinated against PRRS. The immunoassays provide detection of at least a portion of the N terminal region of the 2b portion of PRRSV. The immunoassay is preferably an enzyme-linked immunosorbent assay (ELISA).

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Номер записи: 85
08-03-2012 дата публикации

Method for detecting an antigen

Номер: US20120058490A1
Автор: Kazuaki Nishio, Nozomu Matsukawa, Shigeo Yoshii
Принадлежит: Panasonic Corp

Provided is a method for detecting an antigen without use of a labeled-antibody. A support having an antibody and a multi-copper oxidase CueO immobilized thereon is brought into contact with a first buffer solution containing the antigen, a current is measured by a potentiostat method using the support and a second buffer solution, and when the measured current is greater than or equal to 1.5×(blank value), it is determined that the antigen exists. The second buffer solution contains a substrate of the CueO and has an ionic strength falling within a range of not less than 0.3 mM and not more than 1.0 mM.

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Номер записи: 86
08-03-2012 дата публикации

In situ heat induced antigen recovery and staining method

Номер: US20120058570A1
Автор: Lee Angros
Принадлежит: Individual

An automated in situ heat induced antigen recovery and staining method and apparatus for treating a plurality of microscope slides. The process of heat induced antigen recovery and the process of staining the biological sample on the microscope slide are conducted in the same apparatus, wherein the microscope slides do not need to be physically removed from one apparatus to another. The reaction conditions for treating a slide can preferably be controlled independently, including the individualized application of reagents to each slide and the individualized treatment of each slide.

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Номер записи: 87
08-03-2012 дата публикации

Compositions and methods for treating cancer and methods for predicting a response to such treatments

Номер: US20120059021A1
Автор: Andy J. Chien, Rachel TORONI, Randall T. Moon, Rima KULIKAUSKAS, Travis L. Biechele
Принадлежит: UNIVERSITY OF WASHINGTON

The present disclosure relates to the regulation and function of the Wnt/β-catenin signaling pathway and the ERK signaling pathway. The disclosure provides methods of treatment for melanoma by administering both an inhibitor of ERK signaling and an activator of Wnt/β-catenin signaling. These methods may be used alone or in combination with other strategies targeting melanoma cell survival. The disclosure also provides diagnostic methods for predicting a patient's clinical response to inhibitors of ERK signaling.

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Номер записи: 88
15-03-2012 дата публикации

Psca: prostate stem cell antigen and uses thereof

Номер: US20120063999A1
Автор: Aya Jakobovitz, Douglas C. Saffran, Owen N. Witte, Robert E. Reiter
Принадлежит: Agensys Inc, UNIVERSITY OF CALIFORNIA

The invention provides a novel prostate cell-surface antigen, designated Prostate Stem Cell Antigen (PSCA), which is widely over-expressed across all stages of prostate cancer, including high grade prostatic intraepithelial neoplasia (PIN), androgen-dependent and androgen-independent prostate tumors.

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Номер записи: 89
15-03-2012 дата публикации

Il-17 homologous polypeptides and therapeutic uses thereof

Номер: US20120064073A1
Автор: Audrey Goddard, Austin L. Gurney, Colin K. Watanabe, Daniel G. Yansura, Daniel Tumas, Dorothy French, Ellen Fllvaroff, Hanzhong Li, J. Christopher Grimaldi, James Pan, Jian Chen, Kenneth J. Hillan, Melissa A. Starovasnik, Menno Van Lookeren, P. Mickey Williams, Paul J. Godowski, Richard Vandlen, Sarah G. Hymowitz, Sherman Fong, William I. Wood
Принадлежит: Individual

The present invention is directed to novel polypeptides having sequence identity with IL-17, IL-17 receptors and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders and other inflammatory diseases.

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Номер записи: 90
15-03-2012 дата публикации

Novel Target for Regulating Multiple Sclerosis

Номер: US20120064092A1
Автор: Brian A. Zabel, Eugene C. Butcher, Kareem Graham
Принадлежит: Leland Stanford Junior University, US Department of Veterans Affairs VA

Methods are provided for decreasing demyelinating inflammatory disease in a subject by inhibiting the activity of chemokine-like receptor 1 (CMKLR1). Methods are also provided for screening for agents that find use in treating demyelinating inflammatory disease in a subject.

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Номер записи: 91
15-03-2012 дата публикации

Use of Serum Amyloid A Gene in Diagnosis and Treatment of Glaucoma and Identification of Anti-Glaucoma Agents

Номер: US20120064532A1
Автор: Abbot F. Clark, Loretta Graves Mcnatt, Wan-Heng Wang
Принадлежит: NOVARTIS AG

The present invention provides compositions and methods for treating glaucoma, methods for diagnosing glaucoma, and methods for identifying agents which may be useful in the treatment of glaucoma. More specifically, the present invention describes the use of agents that modulate the expression of serum amyloid A.

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Номер записи: 92
15-03-2012 дата публикации

Method For Detecting And Distinguishing Intrahepatic Cholangiocarcinoma

Номер: US20120065089A1
Автор: Atsushi Kuno, Atsushi Matsuda, Hisashi Narimatsu, Jun Hirabayashi, Junichi Shoda, Toru Kawamoto, Yuzuru Ikehara
Принадлежит: National Institute of Advanced Industrial Science and Technology AIST, University of Tsukuba NUC

Disclosed are a method for early, sensitively and reliably detecting and distinguishing intrahepatic cholangiocarcinoma in a malignant tumor occurring primarily in the liver in a simple way, and a kit therefor. In the method, a glycan biomarker consisting of a lectin WFA (Wisteria floribunda Agglutinin)-binding glycoprotein derived from intrahepatic cholangiocarcinoma is used as a cancer marker to detect intrahepatic cholangiocarcinoma by detecting the cancer marker in a test specimen. The method for detecting intrahepatic cholangiocarcinoma can clearly differentiate intrahepatic cholangiocarcinoma from hepatocellular carcinoma and enables early detection and determination with a performance clinically acceptable in terms of applicability, sensitivity and precision.

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Номер записи: 93
15-03-2012 дата публикации

Quantum dot-encoded bead set for calibration and quantification of multiplexed assays, and methods for their use

Номер: US20120065090A1
Автор: Michael H. Doctolero, Paul Scott Eastman, Rachel L. Nuttall
Принадлежит: Life Technologies Corp

Control beads are disclosed that allow for improved quantitation of analytes in multiplexed bead assays. The control beads have a range of concentrations of calibration moieties that provide for the preparation of a titration curve. The titration curve can be used to quantify the concentration of the analytes. The titration curve can be used to correlate the signal obtained from a bead with the concentration (or absolute number of molecules) of the analyte bound to the bead.

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Номер записи: 94
15-03-2012 дата публикации

Methods and Apparatus for Detecting Molecular Interactions Using FET Arrays

Номер: US20120065093A1
Автор: Jonathan Rothberg, Wolfgang Hinz
Принадлежит: Life Technologies Corp

Methods and apparatuses relating to large scale FET arrays for analyte detection and measurement are provided. ChemFET (e.g., ISFET) arrays may be fabricated using conventional CMOS processing techniques based on improved FET pixel and array designs that increase measurement sensitivity and accuracy, and at the same time facilitate significantly small pixel sizes and dense arrays. Improved array control techniques provide for rapid data acquisition from large and dense arrays. Such arrays may be employed to detect a presence and/or concentration changes of various analyte types in a wide variety of chemical and/or biological processes.

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Номер записи: 95
15-03-2012 дата публикации

Use of the gtpase rab27b to diagnose and treat poor prognosis estrogen-receptor-positive breast cancer

Номер: US20120065147A1
Автор: An Hendrix, Olivier De Wever, Wendy Westbroek
Принадлежит: Individual

The present invention relates to evaluating the prognosis of patients with estrogen receptor-positive breast cancer on the basis of Rab27B expression. The invention further relates to a kit comprising an assay for measuring Rab27B levels in said patients and to the usage of Rab27B as a target to screen for drugs capable of inhibiting or diminishing metastasis of said cancer. Furthermore, the invention discloses compounds which can be used to treat estrogen receptor-positive breast cancer.

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Номер записи: 96
15-03-2012 дата публикации

Identification of a jak2 mutation involved in vaquez polyglobulia

Номер: US20120066776A1
Автор: Chloe James, Jean-Pierre Le Couedic, Nicole Casadevall, Valerie Ugo, William Vainchenker
Принадлежит: Assistance Publique Hopitaux de Paris APHP, IGR&D SA, Institut National de la Sante et de la Recherche Medicale INSERM

The present invention concerns the V617F variant of the protein-tyrosine kinase JAK2, said variant being responsible for Vaquez Polyglobulia. The invention also relates to a first intention diagnostic method for erythrocytosis and thrombocytosis allowing their association with myeloproliferative disorders, or to the detection of the JAK2 V617F variant in myeloproliferative disorders allowing their reclassification in a new nosological group.

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Номер записи: 97
22-03-2012 дата публикации

Fluorescent conjugated polymers with a bodipy-based backbone and uses thereof

Номер: US20120070382A1
Автор: Haiying Liu
Принадлежит: MICHIGAN TECHNOLOGICAL UNIVERSITY

The present invention provides various fluorescent conjugated polymers with a BODIPY-based backbone. The invention also provides methods of using the polymers of the invention, such as for imaging and detection of cells, tumors, bacteria and viruses.

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Номер записи: 98
22-03-2012 дата публикации

Humanized antibodies against west nile virus and therapeutic and prophylactic uses thereof

Номер: US20120070429A1
Автор: Leslie S. Johnson, Ling Huang
Принадлежит: Macrogenics Inc

The present invention relates to compositions comprising humanized antibodies or fragments thereof that immunospecifically bind to one or more antigens of a flavivirus, particularly of West Nile Virus (WNV) and methods for preventing, treating or ameliorating symptoms associated with a flavivirus, particularly of West Nile Virus (WNV) infection utilizing said compositions. In particular, the present invention relates to methods for preventing, treating or ameliorating symptoms associated with WNV infection, said methods comprising administering to a human subject an effective amount of one or more humanized antibodies or fragments thereof that immunospecifically bind to a WNV antigen. The present invention also relates to detectable or diagnostic compositions comprising humanized antibodies or fragments thereof that immunospecifically bind to a WNV antigen and methods for detecting or diagnosing WNV infection utilizing said compositions.

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Номер записи: 99
22-03-2012 дата публикации

Use of myeloid cell biomarkers for the diagnosis of cancer

Номер: US20120070461A1
Автор: Harpreet Singh, Regina MENDRZYK, Steffen Walter, Susanna Mandruzzato, Vincenzo Bronte
Принадлежит: IMMATICS BIOTECHNOLOGIES GMBH

The present invention relates to the use of myeloid cell biomarkers for the differential diagnosis, prognosis, and monitoring of renal cell carcinoma (RCC) or colorectal cancer (CRC). The present invention furthermore relates to monitoring the effect of a treatment against renal cell carcinoma (RCC) or colorectal cancer (CRC), and establishing a prognosis of the outcome of the treatment of renal cell carcinoma (RCC) or colorectal cancer (CRC). The present invention furthermore relates to panels of cellular biomarkers for use in the above methods, in particular multicolor panels for measuring said biomarkers.

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Номер записи: 100