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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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Поддерживает ввод нескольких поисковых фраз (по одной на строку). При поиске обеспечивает поддержку морфологии русского и английского языка
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Применить Всего найдено 5381. Отображено 100.
08-03-2012 дата публикации

In situ heat induced antigen recovery and staining method

Номер: US20120058570A1
Автор: Lee Angros
Принадлежит: Individual

An automated in situ heat induced antigen recovery and staining method and apparatus for treating a plurality of microscope slides. The process of heat induced antigen recovery and the process of staining the biological sample on the microscope slide are conducted in the same apparatus, wherein the microscope slides do not need to be physically removed from one apparatus to another. The reaction conditions for treating a slide can preferably be controlled independently, including the individualized application of reagents to each slide and the individualized treatment of each slide.

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Номер записи: 1
24-05-2012 дата публикации

Centrifugal separator

Номер: US20120129673A1
Автор: Hiroshi Oga, Kuniaki Onizawa, Shigemi Oba, Tatsuya Fukugaki, Tetsuya Isobe
Принадлежит: Hitachi High Technologies Corp

The weight difference is limited between buckets ( 17 ) mounted at respective symmetrical positions with respect to a centrifugal separation rotational center and examination of samples is continuously performed in the order in which they are received. In particular, when a sample ( 21 ) is carried in a centrifugal buffer line ( 11 ), its weight is measured by weight measuring means ( 31 ). It is assumed that the names of two adaptors ( 22 ) placed at respective symmetrical positions with respect to the centrifugal separation rotational center are defined as an adaptor A and an adaptor B. A first sample is put on the adaptor A and a second sample is put on the adaptor B. Then, a third sample and subsequent ones are each put on the adaptor ( 22 ) lighter than the other adaptor after the total weights of samples put on the adaptors are computation-compared with each other.

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Номер записи: 2
02-08-2012 дата публикации

Slide Processing Apparatus and Method

Номер: US20120195497A1
Автор: Alan Prile, Ian Kerrod, John Temple, Roger Smith, Stephen Hankey
Принадлежит: Thermo Shandon Ltd

A basket processing apparatus that includes a basket storage portion in a form of a horizontal load rail. A plurality of slide storage baskets can be located in series on the rail. Each basket is ‘side loading’ and the side loading aperture of each basket can be selectively covered by a slide retaining bar. When the baskets are placed on the load rail, the basket can be moved along the horizontal rail by a basket moving means. The arrangement of the rail and the basket moving means is such that the baskets can be pushed together and move as a ‘train’. Baskets moved to the pick-up end of the rail can then be removed from the rail and processed. A vertical lift mechanism can be used to remove the basket and transport it to a processing device, for example a coverslipper.

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Номер записи: 3
02-08-2012 дата публикации

Apparatus and methods for microfluidic applications

Номер: US20120195809A1
Автор: Douglas Roy, Joel Fearnley, Peter Ghazal, Stuart Polwart
Принадлежит: AGILENT TECHNOLOGIES INC

Non-rigid tape apparatus and fabrication methods for microfluidic processing applications such as gel electrophoresis are provided, where microfluidic processing is performed on selected areas. Parts of the tape are formed by high pressure plastic film forming. Membranes and other structures are self sealing during and after penetration by pipettes and electrical probes. Rigid exoskeleton elements protect the non-rigid parts during processing and facilitate transport of the tape.

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Номер записи: 4
06-09-2012 дата публикации

Stack of test strips and method for the production thereof

Номер: US20120224996A1
Автор: Herbert Harttig
Принадлежит: Roche Diagnostics Operations Inc

A stack of test strips comprises individual test strips which are stacked over each other and carry a test field for examining a bodily fluid sample. Test strips lying one on top of the other are detachably adhesively bonded to each other so that the test strips can be individually removed from the stack, wherein the test fields are packed in chambers and adjacent test strips form the bottom and the lid of such a chamber. A method for producing such a stack of test strips is also disclosed.

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Номер записи: 5
15-11-2012 дата публикации

System for handling slides having a linear transport mechanism for transporting the racks

Номер: US20120290127A1
Автор: Bernhard NEEF, Karl-Heinz Westerhoff, Simon Keimer
Принадлежит: LEICA BIOSYSTEMS NUSSLOCH GMBH

The present invention relates to a system ( 10, 100 ) for handling slides, including an input compartment ( 14 ) for inputting racks ( 16 ) and the slides held therein, and a coverslipper module ( 30, 32 ) for coverslipping slides. The system ( 10, 100 ) further includes an output compartment ( 22 ) for outputting racks ( 16 ), a transport unit ( 20 ) for transporting the racks ( 16 ), and a control unit ( 52 ) for controlling the transport unit ( 20 ). The transport unit ( 20 ) is designed to be capable of transporting the racks ( 16 ) between the input compartment ( 14 ), the coverslipper module ( 30, 32 ) and the output compartment ( 22 ).

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Номер записи: 6
06-12-2012 дата публикации

Biosample plate with data storage and wireless communication means

Номер: US20120309111A1
Автор: Anna Wanda Topol, Daniel James Winarski, Nils Haustein, Thorsten Krause
Принадлежит: International Business Machines Corp

Embodiments of the disclosure relate to a biosample plate that includes a memory component for storing information related to the biosample, biosample plate and biosample analysis data, and a wireless communication interface for transferring information to and from the biosample plate. The biosample plate may be used with an analyzing and data recording system such as an electromagnetic tape drive. The disclosed biosample plate facilitates the correlation between a large number of biosample plates and data as data remains with the corresponding biosamples both when the biosample plates are in use and when they are in storage. The wireless communication interface may comprise an antenna disposed in a biosample plate for data transmission to and from the biosample plate by radio signals.

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Номер записи: 7
24-01-2013 дата публикации

Fluid sample preparation systems and methods

Номер: US20130019697A1
Автор: Brian J. Mckeen, Eric D. YEATON, James L. Dowling
Принадлежит: Constitution Medical Inc

Sample application systems can include an extraction mechanism to remove a sample from sample containers, a sample vessel disposed on a deployment mechanism, where the deployment mechanism is arranged to move the sample vessel to receive a sample, an extraction mechanism washing station to wash the extraction mechanism, a sample applicator to remove a portion of the sample in the sample vessel and apply it onto a sample carrier, where the deployment mechanism can move the sample vessel to a sample application position, a sample vessel washing station to wash the sample vessel, where the deployment mechanism can move the sample vessel to the sample vessel washing station, a sample applicator washing station to wash the sample applicator after the sample has been dispensed onto the sample carrier, and a fluid control system to control flow of a fluid provided to the extraction mechanism and the sample applicator.

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Номер записи: 8
24-01-2013 дата публикации

Sample applicator sensing and positioning

Номер: US20130021461A1
Автор: David J. Zahniser, Eric LEKNES, Frank L. Pawlowski, Michael Zahniser, Russell ZAHNISER, Stephen Conroy
Принадлежит: Constitution Medical Inc

Systems and methods for positioning a sample applicator relative to a substrate include: (a) obtaining an image of the sample applicator in proximity to the substrate, where the image includes a direct image region corresponding to the sample applicator and a first reflected image region corresponding to an image of the sample applicator reflected from a surface of the substrate; (b) determining a position of an edge of the sample applicator in the direct image region; (c) determining a position of a reflected edge of the sample applicator in the first reflected image region; (d) determining a distance between the edge of the sample applicator and the reflected edge of the sample applicator; and (e) determining the position of the sample applicator relative to the substrate based on the distance between the edges.

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Номер записи: 9
20-06-2013 дата публикации

Method for producing an analytical consumable

Номер: US20130153152A1
Автор: Joerg Dreibholz, Wolfgang Schwoebel
Принадлежит: Roche Diagnostics Operations Inc

A method for producing an analytical consumable is proposed. The analytical consumable comprises at least one carrier and at least one analytical aid connected to the carrier. At least one optically sensitive material is applied to the carrier, said material being designed to carry out at least one optically detectable alteration in the event of action of an electromagnetic radiation. In at least one coding step, at least one function information item about the analytical consumable is introduced into the optically sensitive material by means of electromagnetic radiation. The function information item is designed to enable at least one analytical instrument to use the analytical consumable correctly.

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Номер записи: 10
20-06-2013 дата публикации

Waste ramp for reagent cards

Номер: US20130157372A1
Автор: Aaron Sung-Lien Tang, Kenneth Galano, Michael Parker
Принадлежит: Siemens Healthcare Diagnostics Inc

An automated analyzer for reagent cards having a leading end, a trailing end and a length between the leading end and the trailing end comprises a travel surface assembly having a card travel surface and an edge. A test analyzing mechanism is adjacent to the travel surface, and a waste receptacle is adjacent to the edge below the travel surface. The waste receptacle has a side and a waste cavity. A ramp member positioned below the travel surface has an end and a sloped surface, and is movable between an extended position where the sloped surface extends into the waste cavity, and a retracted position where the end is spaced from the side a distance greater than the length of the reagent card. A moving mechanism operably coupled with the ramp member is configured to move the ramp member between the extended position and the retracted position.

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Номер записи: 11
18-07-2013 дата публикации

Integrated Test Device for Optical Detection of Microarrays

Номер: US20130184188A1
Автор: Graham Davis, Katrina Di Tullio, PIERRE Emeric, Sergey Gershtein, Smitha Sutrala, Thomas Ewart
Принадлежит: ABBOTT POINT OF CARE INC

This invention relates generally to devices and methods for performing optical and electrochemical assays and, more particularly, to testing devices having an optically readable microspot array and/or an electrochemical detector and to methods of performing microspot arrays and electrochemical assays using such devices. The present invention is particularly useful for performing immunoassays and/or electrochemical assays at the point-of-care.

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Номер записи: 12
26-09-2013 дата публикации

Sample packing device

Номер: US20130251603A1
Автор: Hisashi Hagiwara, Minoru Asogawa, Tohru Hiramatsu
Принадлежит: NEC Corp

Provided is a sample packing device for packing a sample with respect to a microchip for performing reaction of a micro component contained in the sample, the microchip at least including: a sample reservoir; a reaction reservoir; and a channel connected between the sample reservoir and the reaction reservoir, in which a package including a sample chamber packed in advance with the sample is mounted on the microchip so as to pack the sample in the sample chamber into the sample reservoir.

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Номер записи: 13
03-10-2013 дата публикации

Apparatus for inspecting filler in container, apparatus for filling filler, and method for inspecting filler in container

Номер: US20130255832A1
Автор: Toyokazu Uchida
Принадлежит: Mitsubishi Heavy Industries Ltd

A container filler-inspecting apparatus includes a weight-measuring unit ( 14 ) that measures the weight of the container ( 1 ) filled with a filler (S 1 ), a sample-extracting unit ( 12 ) that extracts a fixed amount of filler (S 1 ) from a tip opening ( 2 ) of the container ( 1 ), and a sampling unit ( 13 ) that performs a sampling operation by wiping off the filler extracted by the sample-extracting unit ( 12 ) with a sampling paper sheet.

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Номер записи: 14
24-10-2013 дата публикации

Automatic calibration of a microscope scanning system

Номер: US20130278941A1
Автор: Thomas Loerch
Принадлежит: Metasystems Hard and Software GmbH

The invention provides a method for automatic calibration of slides and a method for automatic calibration of slide frames and a slide for performing the method. To this end, slide frames ( 4; 210 ) with at least one slide seat and slide ( 212 a - 212 h; 300 ) are provided with a calibration marking ( 304 ). In particular the inventive slide ( 212 a - 212 h; 300 ) includes a slide substrate ( 302 ) and a calibration marking ( 304 ), the calibration marking ( 304 ) being connected to the slide substrate ( 302 ).

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Номер записи: 15
24-10-2013 дата публикации

APPARATUS AND METHODS FOR DISPENSING SAMPLE HOLDERS

Номер: US20130280024A1
Автор: Dahlstrom Paul, Talmer Mark
Принадлежит:

An apparatus and methods for dispensing sample holders for use in an automated sample analyzer is disclosed herein. The apparatus for dispensing sample holders includes a rotating carousel for housing stack of sample holders. Stacks of sample holders from the rotating carousel are fed into a chute where sample holders contact a set of rotating members having helical threads thereon. The helically threaded rotating members engage the sample containers and separate each sample holder from the remaining sample holders in the stack by rotation of the helically threaded rotating members. The sample holder can then be transferred for use in an automated sample analyzer. 127-. (canceled)28. A device for separating a sample holder from a stack of at least two sample holders , comprising:a support member for receiving a stack of at least two sample holders;a first releasing member comprising a taper and a second releasing member, said first releasing member comprising a first helical thread and said second releasing member comprising a second helical thread, each of said first releasing member and said second releasing member having a first end and a second end,said support member being positioned to introduce the stack of at least two sample holders between said first releasing member and said second releasing member,wherein the widest part of the first releasing member is the first end of the first releasing member and wherein said first and second releasing members rotate and cooperate thereby releasing one of said at least two sample holders from said stack of sample holders.29. The device of claim 28 , wherein said first helical thread and said second helical thread are of opposite handedness claim 28 , andsaid first releasing member and said second releasing member rotate in opposite directions.30. The device of claim 28 , wherein said second releasing member comprises a taper.31. The device of claim 28 , wherein the widest part of said second releasing member is the ...

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Номер записи: 16
05-12-2013 дата публикации

Fluid sensing and control in a fluidic analyzer

Номер: US20130323126A1
Автор: Aravind Padmanabhan, Ron L. Bardell, Tom M. Rezachek
Принадлежит: Honeywell International Inc

Instrument-cartridge interfaces for fluidic analyzers that have an instrument and a removable cartridge are disclosed. For example, and in one illustrative embodiment, the instrument may include a needle that is adapted to penetrate a septum on a removable cartridge. In another illustrative embodiment, the instrument may include a plunger that is adapted to deform a deformable membrane on a removable cartridge. In yet another illustrative embodiment, the instrument may include a nozzle that is adapted to mate and seal with a flow channel on a removable cartridge. Techniques for detecting the flow rate in a flow channel on a removable cartridge, as well as the position of fluid in a flow channel of a removable cartridge, are also disclosed.

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Номер записи: 17
13-02-2014 дата публикации

Centrifugal particle separation and detection device

Номер: US20140045249A1
Автор: Chih-Chung Chen, Da-Jeng Yao
Принадлежит: National Tsing Hua University NTHU

The present invention provides a centrifugal particle separation and detection device, which can separate and detect particles according to the particle size. The centrifugal particle separate and detection device is practiced with a centrifuge to separate particles, and can be applied to cancer cell detection, blood lymphocyte isolation, tissue engineering, polynucleotide hybridization, microorganism separation and detection and fine chemical purification.

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Номер записи: 18
03-04-2014 дата публикации

Specimen storage device, specimen storing method, and rack

Номер: US20140093425A1
Автор: Yuichiro Ohmae
Принадлежит: Sysmex Corp

To provide a specimen storage device capable of preventing liquid such as immersion oil and the like attached to the specimen plate from leaking to the outside of the rack and capable of enhancing the operation efficiency by automating the supply and discharge of the rack. Provided is a specimen storage device which stores a imaged specimen plate in a bottomed-shaped rack having an opening at an upper part, the specimen storage device including a rack transport mechanism which transports the rack with the opening directed upward, and a specimen transport mechanism which transports the specimen in an up-down direction, wherein the rack transport mechanism transports the rack to a predetermined specimen storage position, and the specimen transport mechanism stores the specimen to the rack positioned at the specimen storage position from above the rack.

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Номер записи: 19
05-01-2017 дата публикации

Automated Seed Sampler and Methods of Sampling, Testing and Bulking Seeds

Номер: US20170003201A1
Автор: Deppermann Kevin L.
Принадлежит:

An automated system for sampling seeds generally includes an automated sampling station having a sampler configured to remove material from a seed while protecting germination viability of the seed, a seed conveyor configured to receive the seed from out of the sampling station after the material is removed from the seed, and a sample conveyor configured to receive the material removed from the seed. The sample conveyor is configured to locate the material removed from the seed in a sample container, and the seed conveyor is configured to locate the seed from which the material is removed in a seed container so as to facilitate a one-to-one correspondence between the seed and the material removed from the seed. 1. An automated system for sampling seeds , the system comprising:an automated sampling station having a sampler configured to remove material from a seed while protecting germination viability of the seed;a seed conveyor configured to receive the seed from out of the sampling station after the material is removed from the seed; anda sample conveyor configured to receive the material removed from the seed;wherein the sample conveyor is configured to locate the material removed from the seed in a sample container, and wherein the seed conveyor is configured to locate the seed from which the material is removed in a seed container so as to facilitate a one-to-one correspondence between the seed and the material removed from the seed.2. The system of claim 1 , further comprising:a table supporting the seed container and the sample container; andan index mechanism operable to move the table to bring the seed container into position for receiving from the seed conveyor the seed from which the material is removed, and to bring the sample container into position for receiving from the sample conveyor the material removed from the seed.3. The system of claim 1 , wherein the sample container includes a sample tray comprising multiple wells claim 1 , and wherein the ...

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Номер записи: 20
05-01-2017 дата публикации

Method, system, and device for automating transfer of tape to microtome sections

Номер: US20170003309A1
Автор: Alexander S. Tolpygo, Partha P. Mitra, Robert L. Kleinberg
Принадлежит: Clarapath Inc

A system and method for automated transfer of a tape segment onto the face of a tissue block to be thin sectioned by microtomy includes applying, to a carrier strip, a plurality of serially-spaced patches of sample tape having an adhesive outer surface, transporting the carrier strip along a path adjacent to and spaced from the exposed sample surface to position one of the patches of sample tape adjacent to and covering the exposed sample surface, adhering the one of the patches of sample tape to the exposed sample surface.

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Номер записи: 21
01-01-2015 дата публикации

Spectrometric device for the analysis of environmental and geological samples

Номер: US20150004714A1
Автор: John David HANBY
Принадлежит: HANBY INTERNATIONAL LLC

A system and method for analyzing contaminants such as hydrocarbons in soil and ground water utilizes a reaction device comprising a catalyst encapsulated in a permeable material and processes that device in contact with a contaminant in an analytical device in order to generate a spectrogram indicative of the contaminants in the soil and ground water.

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Номер записи: 22
01-01-2015 дата публикации

Integrated instrumentation for the analysis of biofluids at the point-of-care

Номер: US20150004717A1
Автор: HAQUE Ahmed, McDevitt John, McRae Michael, SIMMONS Glen
Принадлежит:

This disclosure describes the design and function of a bead-based lab-on-a-chip portable analyzer for analyzing biomarker assay cards used in point-of-care testing. 1. An analyzer for a lab card , said analyzer comprising:a) an optical imaging module located above a sample platform;b) one or more blister actuators located above said sample platform, each blister actuator having a stepper motor for moving said blister actuator up and down and a force sensor resistor for detecting a force on said blister actuator;c) a processor operably connected to said optical imaging module and to said blister actuator, wherein said processor controls and collects data from said optical imaging module, and controls said blister actuator;d) each of components a-c housed inside a housing;e) said housing further comprising a lab card slot in communication with said sample platform and a user interface, wherein the user interface is in communication with said processor.2. The analyzer of claim 1 , wherein said housing further comprises a connector for cables connecting said processor to external display or storage devices.3. The analyzer of claim 1 , wherein said optical imaging module detects fluorescence light signals from a lab card.4. The analyzer of claim 1 , said optical imaging module comprising a microscope claim 1 , a light source claim 1 , and a photodetector for detecting light from a lab card.5. The analyzer of claim 1 , said optical imaging module comprising a microscope claim 1 , a light source claim 1 , one or more optical filters claim 1 , and a photodetector for detecting light from a lab card.6. The analyzer of claim 5 , said optical imaging module an LED light source claim 5 , and a CCD or CMOS camera for detecting fluorescence from a lab card.7. The analyzer of claim 1 , wherein said housing is lightproof when a lab card is inserted into said lab card slot such that external light does not reach said optical imaging module.8. The analyzer of claim 1 , wherein said ...

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Номер записи: 23
04-01-2018 дата публикации

IN SITU HEAT INDUCED ANTIGEN RECOVERY AND STAINING APPARATUS AND METHOD

Номер: US20180003601A1
Автор: Angros Lee H.
Принадлежит:

An automated microscope slide staining system and staining apparatus and method that features a plurality of individually operable miniaturized pressurizable reaction compartments or a pressurizable common chamber for individually and independently processing a plurality of microscope slides. The apparatus preferably features independently movable slide support elements each having an individually operable heating element. 1. A microscope slide staining system , comprising:a chamber having an inner space;a plurality of independently movable slide support elements positioned in the inner space of the chamber, each of the slide support elements configured to support a microscope slide;a spreading device supply station containing a plurality of spreading devices, each of the spreading devices being positionable in association with at least one of the microscope slides supported on the slide support elements in a way that the spreading device defines a gap between the spreading device and the microscope slide when the microscope slide is positioned on the slide support element and in a way that each of the spreading devices is independently movable relative to the other spreading devices to spread at least one reagent on at least a portion of the microscope slide;at least one positioning device operable in a way to pick up and carry at least one of the spreading devices from the spreading device supply station to one of the slide support elements so that the at least one spreading device is associated with the microscope slide supported on the slide support element; anda plurality of heating elements such that at least one of the heating elements is associated with one of the slide support elements to heat the at least one reagent on the microscope slide.2. The microscope slide staining system of claim 1 , wherein each of the spreading devices engages side edges of the microscope slide when the microscope slide is positioned on the slide support element.3. The ...

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Номер записи: 24
02-01-2020 дата публикации

DEVICES AND CARTRIDGES FOR EXTRACTING BIO-SAMPLE REGIONS AND MOLECULES OF INTEREST

Номер: US20200003665A1
Автор: Oei Ting Pau, Ritterbush Stephen
Принадлежит:

Methods, devices, and systems for integrating extraction and purification of bio-sample regions and materials with patient analysis, diagnosis, follow up, and treatment. The invention provides a means to insert disclosed substrates, cartridges, and cartridge-processing instrument or instruments into a standard clinic or pathology laboratory workflow. Specifically, we disclose methods, devices, and systems for inserting standard pathology slides into disclosed cartridges and cartridge-processing instruments, either manually, semi-automatically, automatically, or by robotic means. 110-. (canceled)11. A method of extracting biological material from a biological sample , comprising:mounting a biological sample upon a slide;attaching the slide to a cartridge that contains a film pre-loaded on the cartridge, wherein the film comprises a substrate suitable for extracting biological material from the biological sample;pressing the film against the biological sample mounted upon the slide;ending the pressing of the film against the biological sample mounted upon the slide;removing the film from the cartridge by using a pull tab attached to the film;extracting biological material from the biological sample that has adhered to the film.12. The method of claim 11 , wherein the attaching the slide to a cartridge comprises inserting the slide into grooves in the cartridge that enable the cartridge and slide form a single unit claim 11 , wherein the entire slide is fully enclosed by the cartridge.13. The method of claim 11 , wherein the attaching the slide to a cartridge comprises inserting the slide into grooves in the cartridge that enable the cartridge and slide form a single unit claim 11 , wherein the slide is only partially enclosed by the cartridge.14. The method of claim 11 , wherein the pressing the film against the biological sample mounted upon the slide comprises closing a hinged mechanism which links a top half of the cartridge to a bottom half of the cartridge claim ...

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Номер записи: 25
04-01-2018 дата публикации

MEASUREMENT APPARATUS AND MEASUREMENT METHOD

Номер: US20180003732A1
Автор: Fujiwara Takao, HORII Kazuyoshi, KOSAKO Tatsuya, NOSE Tomoyuki, TOMODA Sayuri
Принадлежит:

Disclosed is a measurement apparatus including: a support mechanism configured to support a cartridge in which a chamber is formed, the chamber being configured to store a measurement sample that generates light an intensity of which varies depending on an amount of a test substance; a photodetector configured to detect the light generated from the measurement sample stored in the chamber; and a reflection member provided between the photodetector and the cartridge supported by the support mechanism, the reflection member having an inner face, the reflection member being configured to reflect, at the inner face, the light generated from the measurement sample stored in the chamber, and guide the light to the photodetector, wherein the reflection member is configured to have an area surrounded by the inner face, the area decreasing from a side where the cartridge supported by the support mechanism is provided toward a side where the photodetector is provided. 1. A measurement apparatus comprising:a support mechanism configured to support a cartridge in which a chamber is formed, the chamber being configured to store a measurement sample that generates light an intensity of which varies depending on an amount of a test substance;a photodetector configured to detect the light generated from the measurement sample stored in the chamber; anda reflection member provided between the photodetector and the cartridge supported by the support mechanism, the reflection member having an inner face, the reflection member being configured to reflect, at the inner face, the light generated from the measurement sample stored in the chamber, and guide the light to the photodetector, whereinthe reflection member is configured to have an area surrounded by the inner face, the area decreasing from a side where the cartridge supported by the support mechanism is provided toward a side where the photodetector is provided.2. The measurement apparatus of claim 1 , wherein the inner face of ...

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Номер записи: 26
02-01-2020 дата публикации

MOLECULAR PROFILING OF TUMORS

Номер: US20200003796A1
Автор: Alarcon Arlet, Bender Ryan P., Loesch David M., McGinniss Matthew J., Pawlowski Traci, PENNY Robert J., von Hoff Daniel D., Wright Alan
Принадлежит:

Provided herein are methods and systems of molecular profiling of diseases, such as cancer. In some embodiments, the molecular profiling can be used to identify treatments for a disease, such as treatments that were not initially identified as a treatment for the disease or not expected to be a treatment for a particular disease. 1. A system for generating a report identifying at least one therapeutic agent for an individual with a cancer comprising:a. at least one device configured to assay a plurality of molecular targets in a biological sample from the individual to determine molecular profile test values for each of the plurality of molecular targets, wherein the molecular targets comprise ERBB2, PTEN, TOP2A, TOPO1 and TS; and i. a reference value for each of the plurality of molecular targets; and', 'ii. a listing of therapeutic agents with efficacy linked to a biological state of at least one member of the plurality of molecular targets;, 'b. at least one computer database comprisingc. a computer-readable program code comprising instructions to input the molecular profile test values and to compare each molecular profile test value with a corresponding reference value in (b)(i) to identify a biological state for each member of the plurality of molecular targets;d. a computer-readable program code comprising instructions to identify at least one therapeutic agent from the listing of therapeutic agents in (b)(ii), wherein the biological state identified in (c) for at least one member of the plurality of molecular targets provides an indication of likely benefit of the at least one therapeutic agent for treating the cancer; ande. a computer-readable program code comprising instructions to generate a report that comprises a listing of the at least one therapeutic agent identified in (d) and the biological state of each molecular target with efficacy linked thereto.2. The system of claim 1 , wherein the molecular profile test values are input into the system from a ...

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Номер записи: 27
07-01-2021 дата публикации

SYSTEM AND METHOD FOR RETRIEVING AND ANALYZING PARTICLES

Номер: US20210003496A1
Автор: Boniface Brian, Chow Will, Ganesan Karthik, Gleason Kyle, Gogoi Priyadarshini, Handique Kalyan, Payne Austin, Sharma Vishal
Принадлежит:

A system and method for isolating and analyzing single cells, including: a substrate having a broad surface; a set of wells defined at the broad surface of the substrate, and a set of channels, defined by the wall, that fluidly couple each well to at least one adjacent well in the set of wells; and fluid delivery module defining an inlet and comprising a plate, removably coupled to the substrate, the plate defining a recessed region fluidly connected to the inlet and facing the broad surface of the substrate, the fluid delivery module comprising a cell capture mode. 1. A system for material processing at a capture substrate comprising a set of wells distributed across a broad face of the capture substrate , the system comprising: a tip, a terminal opening, and a void defined between the tip and the terminal opening, and', 'a positioning device coupled to the tip and providing a range of motion for positioning the terminal opening of the tip with respect to one or more wells of the set of wells of the capture substrate;, 'an aspiration and delivery subsystem comprising an illumination source, an optical sensor, an optical pathway from the illumination source to the capture substrate and from the capture substrate to the optical sensor; and', 'a processor in communication with the aspiration and delivery subsystem and the imaging subsystem;, 'an imaging subsystem comprising the imaging subsystem to generate an image dataset from the set of wells of the capture substrate, wherein the image dataset is captured from a direction perpendicular to the broad surface of the substrate,', 'the processor to generate an analysis characterizing a set of states of the set of wells and contents of the set of wells, and', 'the aspiration and delivery subsystem to, responsive to the analysis, perform at least one of an aspiration operation and a delivery operation with transmission of the tip to individual wells of the set of wells., 'wherein the processor comprises a non-transitory ...

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Номер записи: 28
07-01-2021 дата публикации

Detailed assay protocol specification

Номер: US20210003600A1
Автор: David R. Torgerson, Matthew S. Fisher
Принадлежит: Luminex Corp

Techniques are disclosed relating to assay configuration. Assay devices are often used to determine characteristics of test samples, e.g., using polymerase chain reaction (PCR) or Deoxyribonucleic Acid (DNA) melt techniques. Various disclosed techniques allow detailed specification of assay parameters. This may allow user modification of assays and/or assay development by third parties. In embodiments in which assay parameters are specified using a separate device, these techniques may reduce validation requirements resulting from modified assays. In some embodiments, assay configuration information that may be added/removed/modified may include: a sequence of operations, parameters for the sequence of operations, data processing parameters, call logic rules/dependencies, and/or reporting rules.

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Номер записи: 29
03-01-2019 дата публикации

SYSTEMS, METHODS, AND APPARATUS FOR IN VITRO SINGLE-CELL IDENTIFICATION AND RECOVERY

Номер: US20190005304A1
Автор: Adalsteinsson Viktor A., Gierahn Todd, Loginov Denis, Love J. Christopher, Stockdale Alan
Принадлежит:

Described herein are systems, methods, and apparatus for automatically identifying and recovering individual cells of interest from a sample of biological matter, e.g., a biological fluid. Also described are methods of enriching a cell type of interest. These systems, methods, and apparatus allow for coordinated performance of two or more of the following, e.g., all with the same device, thereby enabling high throughput: cell enrichment, cell identification, and individual cell recovery for further analysis (e.g., sequencing) of individual recovered cells. 1. A multiscale deposition-well plate (e.g. for use with a system for automated identification and/or recovery of individual cells of interest as described herein) comprising one or more sample wells (e.g. , from three to twenty , or from three to twelve) and zero or more recovery wells (e.g. , 24 , 48 , 96 , at least 24 , at least 48 , at least 96 , etc.).2. The multiscale deposition-well plate of claim 1 , comprising a plurality (e.g. claim 1 , an array) of macro-scale wells (e.g. claim 1 , each macro-scale well with any one or more of length claim 1 , width claim 1 , and/or depth of at least 1 mm claim 1 , at least 3 mm claim 1 , at least 5 mm claim 1 , or at least 8 mm claim 1 , and/or with any one or more of length claim 1 , width claim 1 , and/or depth no greater than about 100mm claim 1 , no greater than about 50 mm claim 1 , or no greater than about 25 mm) claim 1 , wherein each of the macro-scale wells comprise a plurality of micro-scale and/or nano-scale wells (e.g. claim 1 , each micro-scale well with any one or more of length claim 1 , width claim 1 , and/or depth of at least 1μm claim 1 , at least 5μm claim 1 , or at least 10 μm claim 1 , and/or with any one or more of length claim 1 , width claim 1 , and/or depth no greater than about 1000 μm claim 1 , no greater than about 500 μm claim 1 , no greater than about 250 μm claim 1 , or no greater than about 100 μm) (e.g. claim 1 , each nano-scale well ...

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Номер записи: 30
04-01-2018 дата публикации

Systems And Methods For Analyzing Body Fluids

Номер: US20180007319A1
Автор: Linder James, Tanasijevic Milenko, Winkelman James, Zahniser David
Принадлежит:

Systems and methods analyzing body fluids contain cells including blood, bone marrow, urine, vaginal tissue, epithelial tissue, tumors, semen, and spittle are disclosed. The systems and methods utilize an improved technique for applying a monolayer of cells to a slide and generating a substantially uniform distribution of cells on the slide. Additionally aspects of the invention also relate to systems and method for utilizing multi-color microscopy for improving the quality of images captured by a light receiving device. 156-. (canceled)57. An automated process comprisingfilling an applicator with a sample of body fluid containing one or more cells;positioning a tip of the applicator above a transparent substrate;dispensing a known volume of the body fluid sample out of the applicator and while ejection of the body fluid onto the transparent substrate is occurring, maintaining relative movement between the applicator tip and the transparent substrate to lay down the entire known volume of body fluid in two or more rows over a defined area of the transparent substrate, wherein a height of the applicator tip above the transparent substrate, a flow rate of the body fluid out of the applicator tip, and a speed of the relative movement are controlled such that cells in the body fluid settle onto the transparent substrate in a monolayer that is about one cell thick and such that morphology of the cells is sufficiently preserved to enable image-based cell analysis;illuminating the cells on the transparent substrate with a light source;capturing at least one image of the illuminated cells;storing the one or more images in a memory; andautomatically analyzing at least one image of the cells in the memory to determine whether the body fluid sample dispensed onto the substrate is sufficiently dilute or concentrated in a quantity of cells to form the monolayer of cells for analysis, wherein if the analysis indicates that the body fluid sample on the substrate is too ...

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Номер записи: 31
12-01-2017 дата публикации

Apparatus and Methods for Controlling Application of a Substance to a Substrate

Номер: US20170007995A1
Автор: Anthony B. Dejoseph, Anthony V. Moscato, Henderikus A. Haan, John E. Conour, Kevin J. Hook, Theodore F. Cyman, Jr.
Принадлежит: RR Donnelley and Sons Co

Apparatus and methods for controlling application of a substance to a substrate involve the use of a functional agent that helps determine the association of a substance with the substrate. The apparatus and methods may utilize jet technology to apply the functional agent directly to the substrate or to an intermediate surface. The substance may be biological substance or a chemical in nature.

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Номер записи: 32
08-01-2015 дата публикации

AUTOMATED ANALYZER

Номер: US20150010436A1
Автор: Nakamura Kazuhiro, Okusa Takenori, SUZUKI Yoshihiro
Принадлежит: HITACHI HIGH-TECHNOLOGIES CORPORATION

To provide an automated analyzer adapted for accommodating a larger number of reagent cassettes to meet calls for increases in analytical throughput and in the number of analytical items, and thus using the accommodated reagent cassettes more efficiently. An automated analyzer body includes a main reagent buffer for storing a plurality of reagent cassettes each containing a reagent used for analysis and a subsidiary reagent buffer . A reagent cassette transfer transfers the reagent cassettes from the main reagent buffer to the subsidiary reagent buffer, and vice versa. A control unit operates so that when a reagent cassette that is not set in the main reagent buffer is to be used for an assigned analysis, the reagent cassette for the assigned analysis is transferred from the subsidiary reagent buffer to the main reagent buffer. 1. An automated analyzer comprising:a main reagent buffer for storing a plurality of reagent cassettes each containing a reagent used for analysis;a reagent pipetter for pipetting a desired reagent from the main reagent buffer;a subsidiary reagent buffer for storing a plurality of reagent cassettes each containing a reagent used for analysis;a reagent cassette transfer for transferring the reagent cassettes from the main reagent buffer to the subsidiary reagent buffer, and vice versa;a plate disposed on the main reagent buffer for moving the reagent cassettes; anda control unit configured to control operation of the reagent cassette transfer, whereinthe control unit operates so that when a reagent cassette that is not set in the main reagent buffer is to be used for an assigned analysis, the reagent cassette for the assigned analysis is transferred from the subsidiary reagent buffer to the main reagent buffer.2. The automated analyzer according to claim 1 , whereinthe control unit schedules ordering of analyses so that the analyses using the reagent cassettes placed on the same plate for a plurality of biological samples will be continuously ...

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Номер записи: 33
11-01-2018 дата публикации

Target Analysis Chip and Target Analysis Method

Номер: US20180008981A1
Автор: Kobori Akio, KONDO Masayuki, Murakami Akira, Noda Yuichiro, Yamayoshi Asako
Принадлежит:

The present invention provides a novel target analysis chip and analysis method for directly detecting a target such as a microRNA without performing PCR. 1. A target analysis chip , comprising a substrate , the substrate comprising a reaction section at which a sample containing a target is made to react with a reagent , a detection section at which label detection is performed , and a flow channel that communicates the reaction section with the detection section , wherein:the reagent comprises a carrier;the carrier comprises a labeled probe immobilized thereon, the labeled probe being configured to bind to the target, and the carrier having specific gravity of greater than 1 and being configured to form a conjugate with the target;the flow channel comprises a movement controller configured to control movement of the carrier from the reaction section to the detection section;the movement controller comprises a hydrophobic inner wall in the flow channel; anddue to the movement controller, the conjugate is made to move to the detection section through the flow channel when a centrifugal force (C2), that is larger than a resistance force (R) caused by the hydrophobicity of the flow channel, is applied.2. The target analysis chip according to claim 1 , wherein the flow channel has a structure that narrows in a direction from the reaction section toward the detection section.3. The target analysis chip according to claim 1 , wherein the detection section has a height of from 1 μm to 500 μm.4. The target analysis chip according to claim 1 , wherein a volume of an internal space of the detection section is smaller than a volume of an internal space of the reaction section.5. The target analysis chip according to claim 1 , wherein the carrier is a bead.6. The target analysis chip according to claim 5 , wherein the bead has a diameter of from 100 nm to 4 μm.7. The target analysis chip according to claim 1 , wherein the carrier is made of silica.8. The target analysis chip ...

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Номер записи: 34
14-01-2021 дата публикации

METHOD FOR PROTECTING AND UNPROTECTING THE FLUID PATH IN A CONTROLLED ENVIRONMENT ENCLOSURE

Номер: US20210008540A1
Автор: CICHY Marcin, PROCYSHYN Christopher
Принадлежит:

A controlled environment enclosure comprises a robotic arm manipulation system used to protect and unprotect a fluid path and a swab within the controlled environment enclosure. The apparatus allows the fluid path to be protected against dangerous decontamination vapors and chemicals before the controlled environment enclosure is decontaminated. The apparatus allows the fluid path to be unprotected without the use of gloves or other means that degrade the integrity of the controlled environment enclosure when decontamination is completed. The apparatus and method allow for the protecting, unprotecting and decontaminating sequences to be automated. In some embodiments the fluid path comprises a fill needle that can removably and aseptically be sealed with a disposable monolithic injection moulded polymeric fill needle sheath. The apparatus and method further allow for the use of a swab disposed in a swab holder that is aseptically and removably sealable to a swab cap to protect the swab against decontamination vapors. 1. A pharmaceutical fill needle system for dispensing pharmaceutical fluids within an aseptic chamber , the fill needle system comprising:a first sterilizable encapsulation portion comprising at least one first mechanical engagement feature and a first sealable surface;a fill needle aseptically sealed to the first encapsulation portion and having a fluid receiving end and a fluid dispensing end, the fluid dispensing end protruding from the first encapsulation portion;a sterilizable fluid path aseptically sealed to the first encapsulation portion, a proximal end of the fluid path being in fluid communication with the fluid receiving end of the fill needle; anda second sterilizable encapsulation portion comprising at least one second mechanical engagement feature and a second sealable surface, the at least one second mechanical engagement feature releasably engaged with the at least one first mechanical engagement feature and the second sealable surface ...

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Номер записи: 35
14-01-2021 дата публикации

INSTRUMENT FOR PREFORMING A DIAGNOSTIC TEST ON A FLUIDIC CARTRIDGE

Номер: US20210008560A1
Автор: Arlett Ben, Edwards Tom
Принадлежит:

Instrument for performing a diagnostic test on a fluidic cartridge A cartridge reader is for carrying out a diagnostic test on a sample contained in a fluidic cartridge inserted into the reader. The fluidic cartridge comprises a fluidic layer comprising at least one sample processing region, at least one collapsible blister containing a liquid reagent, a pneumatic interface, an electrical interface and at least one mechanical valve. The reader comprises a housing; an upper clamp occupying a fixed position relative to the reader, and a lower clamp, movable relative to the first clamp, wherein the upper clamp and the lower clamp define a cartridge receiving region therebetween. The reader comprises a thermal module comprised in the lower clamp, wherein the thermal module comprises at least one thermal stack for heating the at least one sample processing region of the cartridge inserted into the reader. The reader comprises at least one mechanical actuator for actuating the mechanical valve comprised in the cartridge inserted into the reader. 123-. (canceled)24. A fluidic cartridge for carrying out a diagnostic test on a sample contained therein , the cartridge comprising: a housing;', 'an upper clamp occupying a fixed position relative to the reader and a lower clamp movable relative to the upper clamp, wherein the upper clamp and the lower clamp define a cartridge receiving region therebetween, wherein the cartridge receiving region comprises a tray configured to move between an open position and a closed position and to receive a cartridge;', 'a thermal module comprised in the lower clamp;', 'a pneumatics module comprising a plurality of pneumatic interface;', 'at least one mechanical actuator;', 'at least one blister actuator;', 'an electrical module comprising a plurality of pins; and', 'a barcode reader, wherein at least part of each of the pneumatics module, the at least one mechanical actuator, the at least one blister actuator, the electrical module and the ...

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Номер записи: 36
27-01-2022 дата публикации

SPECIMEN PROCESSING SYSTEMS, PIPETTE ASSEMBLIES AND METHODS FOR PREPARING REAGENTS

Номер: US20220026321A1
Автор: Barnett Donald M., Cisneroz Robert Javier, MCDONALD Timothy Brett, OHaire Christopher, Ruhl Jason, Tessen John Charles
Принадлежит:

Systems and methods that enable automated processing of specimens carried on microscope slides are described herein. Aspects of the technology are directed, for example, to automated slide processing apparatuses capable of dispensing liquids onto microscope slides. Additional aspects of the technology are directed to methods of replacing a reagent pipette in automated slide processing apparatuses. The apparatus can include, for example, a reagent pipette assembly including a reagent pipette moveable between at least one loading position for obtaining reagent from a reagent container at a filling station and at least one dispense position. The apparatus can also include a retainer for releasably securing the reagent pipette. In some embodiments, the reagent pipette assembly includes a locking mechanism for transitioning the retainer from an open configuration for receiving a pipette and a closed configuration for securing a pipette, in e.g., an aligned position within the retainer. 1. A reagent pipette for dispensing liquids onto one or more microscope slides , the reagent pipette comprising:a proximal end portion configured to couple with a body of a reagent pipette assembly, the proximal end portion including a proximal opening;a distal end portion opposite the proximal end portion; anda tubular main body extending between the proximal and distal end portions and including non-circular outwardly facing surface portion, wherein the non-circular outwardly facing surface portion is configured to circumferentially orient the reagent pipette with respect to a retainer when the reagent pipette is inserted into the retainer and to inhibit rotation of the reagent pipette with respect to the retainer by being engaged by a rotation inhibitor of the retainer on the non-circular outwardly facing surface portion when the retainer secures the reagent pipette, wherein the rotation inhibitor disengages the reagent pipette when the reagent pipette is removed from the retainer, ...

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Номер записи: 37
12-01-2017 дата публикации

SMEAR STAINING MACHINE AND SMEARING CONTROL METHOD AND DEVICE THEREOF

Номер: US20170010191A1
Автор: Jiang Bin, SHEN Tao, XUE Shubin
Принадлежит:

A smear staining machine and a smearing control method and device thereof. The viscosity of the test sample is used for guiding the configuration of at least one smearing parameter. Because the viscosity of the test sample presents multiple influences of many effecting parameters, it is more suitable for presenting the characteristics of the test sample. Therefore, a better smearing effect could be acquired by referring the viscosity of the test sample to get the smearing parameter. 1. A smear control method for controlling a smear staining machine , comprising:determining at least one smearing parameter according to a viscosity of a test sample; andcontrolling a smear action according to the smearing parameter.2. The smear control method of claim 1 , wherein determining at least one smearing parameter according to a viscosity of a test sample comprises:measuring a viscosity characteristic of the test sample when the test sample flows through a pipeline under a preset condition, wherein the viscosity characteristic is a physical quantity influenced by the viscosity of the test sample when the test sample flows, and the physical quantity is a function of viscosity;processing the viscosity characteristic of the test sample to generate a processing result; anddetermining the smearing parameter according to the processing result.3. The smear control method of claim 2 , further comprising:determining the smearing parameter according to a relative viscosity of the test sample, wherein the relative viscosity of the test sample is a viscosity of the test sample relative to a known apparent viscosity of a reference fluid at a smearing temperature, and wherein processing the viscosity characteristic of the test sample comprises:comparing the viscosity characteristic of the test sample with a viscosity characteristic of the reference fluid when the reference fluid flows through the pipeline under the same preset condition to generate a comparison result; andcalculating the ...

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Номер записи: 38
12-01-2017 дата публикации

AUTOMATED SPECIMEN PROCESSING SYSTEMS AND MULTISTEP PROCESSING OF MICROSCOPE SLIDES

Номер: US20170010194A1
Автор: HOWLEY PAUL, Showalter Wayne A., Smith Nathan
Принадлежит:

Systems and methods that enable automated processing of specimens carried on microscope slides are described herein. Aspects of the technology are directed, for example, to automated specimen processing systems and methods for dispensing liquids onto slides. The system can concurrently or sequentially perform lock cycles. Each lock cycle can include lock steps for addressing respective slides to dispense liquid. The lock steps of different lock cycles can be synchronized to prevent any collision between dispensers. 1. An automated method for processing specimen-bearing microscope slides , the automated method comprising:delivering a plurality of specimen-bearing microscope slides to respective slide processing stations;repeatedly performing a first lock cycle that includes positioning a first dispenser sequentially at a plurality of first dispense positions for delivering liquid onto respective slides; andperforming a second lock cycle that includes positioning a second dispenser sequentially at a plurality of second dispense positions for delivering liquid onto respective slides, wherein the second lock cycle is synchronized with the first lock cycle to prevent any collision between the first dispenser and the second dispenser while simultaneously performing the first lock cycle and the second lock cycle.2. The automated method of claim 1 , further comprising synchronizing the second lock cycle with the first lock cycle to prevent any collision between a first dispenser apparatus and a second dispenser apparatus that are capable of colliding when the first dispenser apparatus moves the first dispenser and/or when the second dispenser apparatus moves the second dispenser.3. The automated method of claim 1 , whereinperforming the first lock cycle includes delivering non-staining liquid from the first dispenser onto each of the slides, andperforming the second lock cycle includes delivering liquid from a robotic pipettor of the second dispenser onto each of the slides ...

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Номер записи: 39
14-01-2016 дата публикации

Automated Integrated Slide-Processing System

Номер: US20160011221A1
Автор: Hegedüs Márton, Molnár Béla, Virág Tibor
Принадлежит:

The present invention relates to an integrated automated slide processing system, especially to stain, to cover and to digitize one or more microscope slides () in one turn. Said system comprises, as a single apparatus, at least one incubation drawer, an incubation drawer carrier (), a manipulation tray (), a manipulation arm (), a reagent changing unit (), a washing and rinsing unit, a drop removal unit, a staining/pipetting unit (), a coverslipping unit (), a preview image recording unit (), a digitizing unit () and a control computer () electrically connected with and providing control over said units, wherein each of the one or more unstained and un-covered microscope slides with sample to be stained, covered and digitized is arranged in an incubation drawer having sidewalls defining a vertically constrained slide receiving space, and wherein the above listed units form a treating path along which said microscope slide () is converted into a stained, covered and, at least partially, digitized microscope slide when simultaneously guided over said treating path upon and in harmony with respective control signals provided by the control computer () to the respective units. 149123413141516184918. An integrated automated slide processing system , especially to stain , to cover and to digitize one ore or more microscope slides () with a bottom and a top surface carrying biological samples in one turn comprising , as a single apparatus , at least one incubation drawer , an incubation drawer carrier () , a manipulation tray () , a manipulation arm () , a reagent changing unit () , a washing and rinsing unit , a drop removal unit , a staining/pipetting unit () , a coverslipping unit () , a preview image recording unit () , a digitizing unit () and a control computer () electrically connected with and providing control over said units , wherein each of the one or more unstained and uncovered microscope slides with sample to be stained , covered and digitized is arranged ...

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Номер записи: 40
03-02-2022 дата публикации

A SLIDE OUTPUT MODULE

Номер: US20220034916A1
Автор: AU Brenden Anthony, BOYES Gregory William, GUIRALDENQ Nicolas
Принадлежит: LEICA BIOSYSTEMS MELBOURNE PTY LTD

A slide output module for an automated treatment apparatus for treating tissue samples disposed on slides, the slide output module comprising: a slide output tray assembly comprising a slide output tray adjacent to a slide output cover forming one or more voids between the slide output tray and the slide output tray cover for receiving slides therein, wherein the slide output tray cover comprises a first side with a fluid inlet in communication one of the voids, and a second side configured to form a hydration chamber with a slide in said one of the voids to maintain hydration of the slide with fluid received from the fluid inlet for a designated time following treatment of the slide by the automated staining apparatus. 121-. (canceled)22. A slide output module for an automated treatment apparatus for treating tissue samples disposed on slides , the slide output module comprising:a slide output tray assembly comprising a slide output tray adjacent to a slide output cover forming one or more voids between the slide output tray and the slide output tray cover for receiving slides therein,wherein the slide output tray cover comprises a first side with a fluid inlet in communication one of the voids, and a second side configured to form a hydration chamber with a slide in said one of the voids to maintain hydration of the slide with fluid received from the fluid inlet for a designated time following treatment of the slide by the automated staining apparatus.23. A slide output module of claim 22 , wherein the void is bound by a void ceiling in the second side of the slide output tray cover and the void ceiling comprises a surface configured to maintain hydration of the slide with the fluid received from the fluid inlet.24. A slide output module of claim 23 , wherein the void ceiling has a uniform height relative to the slide to maintain hydration of the slide with the fluid received from the fluid inlet and/or the surface of the void ceiling comprises a finish to ...

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Номер записи: 41
03-02-2022 дата публикации

SYSTEMS, DEVICES, AND METHODS FOR ULTRA-SENSITIVE DETECTION OF MOLECULES OR PARTICLES

Номер: US20220034917A1
Автор: Campbell Todd, Duffy David C., Fournier David, Kagan Michael, Kan Cheuk W., Lawson John, Rivnak Andrew
Принадлежит: Quanterix Corporation

Described are systems, devices, and methods which related to various aspects of assays for detecting and/or determining a measure of the concentration of analyte molecules or particles in a sample fluid. In some cases, the systems employ an assay consumable comprising a plurality of assay sites. The systems, devices, and/or methods, in some cases, are automated. In some cases, the systems, devices, and/or methods relate to inserting a plurality of beads into assay sites, sealing assay sites, imaging assay sites, or the like. 1153.-. (canceled)154. An apparatus for performing an assay , comprising:{'b': 1', '1, 'a disc handler operatively coupled to an assay consumable disc having a surface comprising wells formed in the surface of the assay consumable disc that have a volume between about femtoliter and about picoliter;'}a first liquid injector positioned to apply a sealing liquid to the surface of the assay consumable disc;a second liquid injector positioned to load an assay sample into the wells of the assay consumable disc;a fluid pump positioned to create a flow of a liquid, which contains a suspension of beads, over the surface of the assay consumable disc to insert beads into the wells;a camera configured to acquire an image of the wells of the assay consumable containing assay sample;a computer implemented controller configured and programmed to operate the first liquid injector, the second liquid injector, and the fluid pump, and to receive the image acquired from the camera; anda motor operated by the computer implemented controller and configured to rotate the assay consumable disc about a central axis of the assay consumable disc.155. The apparatus of claim 154 , wherein each well formed in the surface of the assay consumable disc has a volume between about 1 femtoliter and about 1 picoliter.156. The apparatus of claim 154 , wherein well formed in the surface of the assay consumable disc has a volume between about 30 femtoliters and about 60 femtoliters. ...

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Номер записи: 42
21-01-2016 дата публикации

Automated Systems and Methods for Preparing Biological Specimens For Examination

Номер: US20160018302A1
Автор: Conroy Stephen, Lapen Daniel, Licari Mark, McKeen Brian J., Poole Dennis, Yeaton Eric D., Zahniser David
Принадлежит: Roche Diagnostics Hematology, Inc.

The apparatus disclosed herein features a substrate arm and gripper, a platform having a top surface located opposite the substrate when the substrate arm is in a specimen processing position and featuring at least one fluid port located on a surface of the platform facing the substrate and at least one vacuum port located on the surface of the platform facing the substrate, and during operation, the apparatus is configured to (a) dispense a first quantity of fluid from the at least one fluid port to fill a separation between the substrate and the platform, (b) dispense an additional quantity of fluid from the at least one fluid port into the separation to displace a portion of the first quantity of fluid, and (c) remove the portion of the first quantity of fluid from the separation through the at least one vacuum port.

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Номер записи: 43
21-01-2016 дата публикации

Apparatus for analyzing phases of multiphase mixtures

Номер: US20160018322A1
Автор: Ronan VARANGUIEN DE VILLEPIN
Принадлежит: FORMULACTION

The invention relates to an apparatus comprising: a measuring head ( 10 ) having a slot ( 18 ) for receiving a measurement cell ( 26 ) and means ( 28 ) for emitting electromagnetic radiation, and means ( 32, 36 ) for detecting radiation from said emission means ( 28 ) after it has passed through the measurement cell ( 26 ); means ( 16 ) for translatably driving and means ( 12, 14 ) for translatably guiding, allowing the substantially vertical longitudinal movement of the measurement head ( 10 ); at least two recesses ( 44 ) each intended for receiving a measurement cell ( 26 ) and arranged one above the other in a longitudinal direction, the recesses ( 44 ) as well as the driving means ( 16 ) and the guiding means ( 12, 14 ) being configured such that during the translational movement of the measurement head ( 10 ) along the nominal travel thereof each recess is placed inside the slot ( 18 ) of the measurement head ( 10 ).

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Номер записи: 44
21-01-2021 дата публикации

REAGENT CARTRIDGE

Номер: US20210016286A1
Автор: Koch Dale, SWANSON Todd
Принадлежит:

In one embodiment, a cartridge includes at least one compartment and a reagent in the at least one compartment. The reagent is a chemical composition for testing at least one of soil and vegetation for a chemical contained in the soil or vegetation. The reagent can be used in a soil and/or vegetation analysis test. The cartridge can contain an authentication chip to ensure that the reagent is the correct reagent for the analysis test. 1. A cartridge comprising:at least one compartment;a reagent in the at least one compartment, wherein the reagent is a chemical composition for testing at least one of soil and vegetation for a chemical contained in the soil or vegetation; andwherein the cartridge is adapted to cooperate with a soil and/or vegetation analysis system to supply the reagent to the soil and/or vegetation analysis system.2. The cartridge of claim 1 , further comprising an authentication device.3. The cartridge of claim 2 , wherein the authentication device comprises a chip adapted to be connected to a network claim 2 , wherein when connected to the network claim 2 , the authentication chip is accessed by the network to confirm that the cartridge is an authorized cartridge containing the reagent that is specific for a soil and/or vegetation test.4. The cartridge of further comprising a meter to measure an amount of reagent dispensed from the cartridge claim 1 , wherein the meter communicates the amount of reagent dispensed from the cartridge to a network.5. (canceled)6. The cartridge of further comprising a counter to count a number of times reagent is dispensed from the cartridge to determine consumed volume of reagent claim 1 , wherein the counter communicates with a network to communicate the number of times.7. The cartridge of further comprising a time counter to count time for determining an amount of reagent dispensed from the cartridge claim 1 , wherein the time counter communicates with a network to communicate the amount of time.8. The cartridge of ...

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Номер записи: 45
18-01-2018 дата публикации

IN SITU HEAT INDUCED ANTIGEN RECOVERY AND STAINING METHOD

Номер: US20180017471A1
Автор: Angros Lee H.
Принадлежит:

An automated in situ heat induced antigen recovery and staining method and apparatus for treating a plurality of microscope slides. The process of heat induced antigen recovery and the process of staining the biological sample on the microscope slide are conducted in the same apparatus, wherein the microscope slides do not need to be physically removed from one apparatus to another. The reaction conditions for treating a slide can preferably be controlled independently, including the individualized application of reagents to each slide and the individualized treatment of each slide. 1. A method of treating biological samples , comprising:placing a first microscope slide on a first slide support element with the first microscope slide having a first biological sample disposed thereon;moving the first slide support into a treatment chamber of an antigen recovery and staining apparatus so as to position the first microscope slide and the first biological sample in the treatment chamber;treating the first biological sample by applying a first reagent to the first biological sample, heating the first reagent to a desired temperature for a desired period of time, and applying additional reagents of a treatment protocol;placing a second microscope slide position on a second slide support element with the second microscope slide having a second biological sample disposed thereon;moving the second slide support into the treatment chamber of the antigen recovery and staining apparatus so as to position the second microscope slide and the second biological sample in the treatment chamber while the first biological sample continues to be treated in the treatment chamber;treating the second biological sample by applying a second reagent to the second biological sample, heating the second reagent to a desired temperature for a desired period of time, and applying additional reagents of another treatment protocol;determining if one of the first biological sample and the second ...

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Номер записи: 46
17-01-2019 дата публикации

Methods, Systems, and Arrays for Biomolecular Analysis

Номер: US20190018006A1
Автор: Bei Kang, Jayaraman Vasanth, Krishnamurthy Hari Krishnan, Rajasekaran John J., Wang Tianhao
Принадлежит:

Disclosed herein are formulations, substrates, and arrays. Also disclosed herein are methods for manufacturing and using the formulations, substrates, and arrays. Also disclosed are methods for identifying peptide sequences useful for diagnosis and treatment of disorders, and methods for using the peptide sequences for diagnosis and treatment of disorders, e.g., celiac disorder. In certain embodiments, substrates and arrays comprise a porous layer for synthesis and attachment of polymers or biomolecules. 174.-. (canceled)75. A method of assuring uniformly high quality features that are affixed to a surface of a microarray at positionally-defined locations , comprising:a) coating the microarray with a coupling formulation comprising the features;b) soft-baking the coated microarray;c) determining the thickness of the soft-baked microarray;d) optionally stripping off the coat if the thickness of the soft-backed microarray falls outside a first threshold range, and repeating steps (a) through (c);e) exposing the soft-baked microarray to light under a photomask;f) hard-baking the exposed microarray; andg) optionally stripping off the coat if the thickness of the hard-baked microarray falls outside a second threshold range, and repeating steps (a) through (g).76. The method of claim 75 , wherein the photomask comprises a diffusion pattern and an overlay pattern.77. The method of claim 76 , further comprising the steps ofh) determining the tolerance range of the diffusion pattern or the overlay pattern of the hard-baked microarray; andj) optionally stripping off the coat if the tolerance range of the diffusion pattern or the overlay pattern falls outside a tolerance range when compared to a standard diffusion or overlay pattern starting and repeating steps (a) through (j).78. The method of claim 75 , wherein the first threshold range is from 2100 nm to 2700 nm.79. The method of claim 75 , wherein the second threshold range is from 790 nm to 810 nm.80. The method of claim ...

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Номер записи: 47
17-01-2019 дата публикации

SUPER-RESOLUTION FAR-FIELD SCANNING OPTICAL MICROSCOPE

Номер: US20190018026A1
Автор: Gerger Scott, Lawson Brett
Принадлежит: SONY CORPORATION

A microscope slide comprises a substrate disc characterized by a top surface, and a cover glass characterized by a first surface. The substrate disc comprises a first pattern of nano-structures on the top surface; a second pattern of grooves on the top surface; a third pattern of ridges, characterized by a ridge height, on the top surface; and a fourth pattern of microfluidic guidance features. The cover glass comprises a coating of a metallic alloy with non-linear optical properties on the first surface. The cover glass is bonded to the ridges of the substrate disc to form a sealed chamber between the first surface of the cover glass and the top surface of the substrate disc, such that the ridge height determines a height of the sealed chamber. A method of fabricating such a slide and a method of optical interrogation of a fluid sample are also disclosed. 1. A microscope slide comprising: a first pattern of nano-structures on the top surface;', 'a second pattern of grooves on the top surface;', 'a third pattern of ridges, characterized by a ridge height, on the top surface; and', 'a fourth pattern of microfluidic guidance features; and', 'a cover glass characterized by a first surface, the cover glass comprising:', 'a coating of a metallic alloy with non-linear optical properties on the first surface;, 'a substrate disc characterized by a top surface, the substrate disc comprisingwherein the cover glass is bonded to the ridges of the substrate disc to form a sealed chamber between the first surface of the cover glass and the top surface of the substrate disc, such that the ridge height determines a height of the sealed chamber.2. The microscope slide of wherein the first pattern of nano-structures is configured to interact with a fluid sample such that particles of interest in the sample are contained claim 1 , guided claim 1 , and/or otherwise positioned within the chamber to allow for optical interrogation using a microscope.3. The microscope slide of wherein the ...

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Номер записи: 48
16-01-2020 дата публикации

FLUID OPERATION CELL WITH ON-CHIP ELECTRICAL FLUID OPERATION COMPONENTS

Номер: US20200018773A1
Автор: GE NING, George David, Holder Helen A.
Принадлежит: Hewlett-Packard Development Company, L.P.

In one example in accordance with the present disclosure, a fluid operation cell is described. The fluid operation cell includes a micro-electro-mechanical housing. The housing includes an inlet and an outlet through which fluid flows and electrodes disposed on an interior of the housing to couple to a controller. The fluid operation cell also includes a silicon-based substrate disposed inside, and electrically coupled to, the housing. The substrate includes an on-chip electrical fluid operation component formed thereon. The electrical fluid operation component uses an electrical signal to operate on bypassing fluid. The fluid operation cell includes a dedicated address to be individually activated by the controller. 1. A fluid operation cell comprising: passages through which fluid flows; and', 'electric traces disposed on an interior of the housing to couple to a controller;, 'a microelectromechanical housing comprising the substrate comprises an on-chip electrical fluid operation component formed thereon;', 'the electrical fluid operation component uses an electrical signal to operate on bypassing fluid; and', 'the fluid operation cell includes a dedicated address to be individually activated by the controller., 'a semiconductive substrate disposed inside, and electrically coupled to the housing, wherein2. The cell of claim 1 , wherein the cell is a microfluidic operational device.3. The cell of claim 1 , wherein the housing further comprises a common electrical interface on an external surface to electrically interconnect the fluid operation cell with other fluid operation cells and the controller.4. The cell of claim 1 , wherein the housing further comprises a common mechanical interface on an external surface to mechanically interconnect the fluid operation cell with other fluid operation cells and the controller.5. The cell of claim 1 , wherein the housing is a printed housing.6. The cell of claim 1 , wherein the housing is an enclosed shape.7. The cell of ...

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Номер записи: 49
22-01-2015 дата публикации

Method and device for the homogeneous distribution of suspended cell components

Номер: US20150024429A1
Автор: Matthew Mette, Michael Otter, Phillip Miller, Stefanie Froehner, Thomas Fischer
Принадлежит: Roche Diagnostics Operations Inc

A method for the homogeneous distribution of cell components suspended in a liquid on a surface and a device for the implementation thereof.

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Номер записи: 50
26-01-2017 дата публикации

IN SITU HEAT INDUCED ANTIGEN RECOVERY AND STAINING APPARATUS AND METHOD

Номер: US20170023449A1
Автор: Angros Lee H.
Принадлежит:

An automated in situ heat induced antigen recovery and staining method and apparatus for treating a plurality of microscope slides. The process of heat induced antigen recovery and the process of staining the biological sample on the microscope slide are conducted in the same apparatus, wherein the microscope slides do not need to be physically removed from one apparatus to another. Each treatment step occurs within the same reaction compartment. The reaction conditions of each reaction compartment for treating a slide can preferably be controlled independently, including the individualized application of reagents to each slide and the individualized treatment of each slide. 1. A method of treating biological samples , comprising:placing a first microscope slide on a first slide support element with the first microscope slide having a first biological sample disposed thereon;placing a second microscope slide on a second slide support element with the second microscope slide having a second biological sample disposed thereon;horizontally moving the first slide support into a treatment chamber of an antigen recovery and staining apparatus so as to position the first microscope slide and the first biological sample in the treatment chamber;horizontally moving the second slide support into the treatment chamber of the antigen recovery and staining apparatus so as to position the second microscope slide and the second biological sample in the treatment chamber;treating the first biological sample by applying a first reagent to the first biological sample, heating the first reagent to a desired temperature for a desired period of time, and applying additional reagents of a treatment protocol;treating the second biological sample by applying a second reagent to the second biological sample, heating the second reagent to a desired temperature for a desired period of time, and applying additional reagents of another treatment protocol;determining if one of the first ...

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Номер записи: 51
26-01-2017 дата публикации

Apparatus and method for biological sample processing

Номер: US20170023450A1
Автор: Ashby Austin, Ghusson Andrew, Jensen-Long Lisa, Knapp Kevin, Kugizaki Rodney, Larson Alain L., Lemme Charles D., Richards Paul, Richards William L., Showalter Wayne, Ward Glen, Wilkinson Chad
Принадлежит:

An apparatus and method are described that achieve independent and simultaneous processing of a plurality of substrate-supported biological samples. In one embodiment, substrate holders arranged in a minor arc are independently moveable between a processing position and an access position, and reagents are delivered to substrates held in the substrate holders through a nozzle plate that moves along the arc of substrate holders. The disclosed apparatus and method are particularly suited for implementation of lean processing of biological samples. 1. An automated biological sample processing apparatus , comprising:a plurality of substrate holders, each substrate holder automatically and independently movable between a different processing position and a different access position; and,a movable substrate processor configured to simultaneously process two or more substrates held on two or more substrate holders in their different processing positions.2. The apparatus of claim 1 , wherein the plurality of substrate holders comprise independent thermal control units.3. The apparatus of further comprising a non-contact temperature sensor positioned to measure a temperature of at least one of an upper surface of a substrate claim 2 , a biological sample on the upper surface of the substrate claim 2 , and a volume of liquid covering at least a portion of the upper surface of the substrate.4. The apparatus of claim 3 , wherein the non-contact temperature sensor is connected in a feedback loop with a power supply for the thermal control unit.5. The apparatus of claim 2 , wherein the independent thermal control units comprise a source of air flow past one or more of the substrate holders.6. The apparatus of claim 5 , wherein each of the plurality of substrate holders has a separate source of air flow.7. The apparatus of claim 6 , wherein the air flow past each of the substrate holders is separated.8. The apparatus of claim 7 , wherein the air flow past each of the substrate ...

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Номер записи: 52
26-01-2017 дата публикации

APPARATUS FOR THE AUTOMATIC PERFORMANCE OF IMMUNOHAEMATOLOGY ANALYSIS ON GEL CARDS

Номер: US20170023561A1
Автор: MARTINELL GISPERT-SAUCH ENRIQUE, PUIG CEBRIA JORDI
Принадлежит:

The apparatus has a containing body with a flat upper functional floor for containing receptacles of reagents, diluents and samples, as well as housings for gel cards and incubators for the same; a lower floor containing receptacles for washing liquids and the collection of waste and cards and for housing the fluid control and electronic control system; a series of longitudinal and transverse guides associated with the upper part of the apparatus, suitable for carrying in suspension the moving heads of the apparatus, the heads being movable on the transverse guides; two heads, respectively for perforation and pipetting and for the transport of gel cards; two centrifuges and a gel card reader; and a folding touch screen providing information and control. 1. An apparatus for automatic immunohaematological analysis on gel cards , wherein the apparatus comprises:a) a containing body with a flat functional upper floor for containing receptacles of reagents, diluents and samples, as well as housings for the gel cards and their incubators;b) a lower floor carrying receptacles for washing liquids and for collection of waste and cards, and for housing a fluidic and electronic control system;c) a set of longitudinal and transverse guides associated with an upper part of the apparatus, suitable for carrying in suspension moving heads of the apparatus, which are movable on the transverse guides;d) two heads, respectively for perforating and pipetting and for transporting the cards;e) two centrifuges and a gel card reader; andf) a folding information and control touch screen.2. The apparatus according to claim 1 , wherein the flat functional upper floor is comprised of a single working level for all tasks claim 1 , having on one of its sides elements relating to reagents claim 1 , diluents claim 1 , samples and a dilution well claim 1 , and on its other side card drawers claim 1 , accesses to centrifuges claim 1 , access to the card reader claim 1 , and access to a bin for scrap ...

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Номер записи: 53
24-01-2019 дата публикации

AUTOMATIC TISSUE STAINING DEVICE AND AUTOMATIC TISSUE STAINING METHOD

Номер: US20190025164A1
Автор: HORIKOSHI Noboru, Kasamatsu Toshiyuki
Принадлежит: NICHIREI BIOSCIENCES INC.

An automatic tissue staining device includes a supply head that supplies a treatment fluid, a horizontal direction movement unit that moves the supply head in a horizontal direction, and a holding unit that holds a plurality of glass slides on which samples are set. The automatic tissue staining device further includes a control unit that judges an occupancy status of the horizontal direction movement unit in a condition that one or more of the glass slides are situated in a first region prior to supplying the treatment fluid from the supply head to one or more samples in the first region, suspends a start of a treatment for the samples in the first region when the horizontal direction movement unit is occupied, and permits the treatment for the samples in the first region when the horizontal direction movement unit is not occupied. 118-. (canceled)19. An automatic tissue staining device comprising:a supply head that supplies a treatment fluid;a holding unit that holds a plurality of glass slides on which samples are set; anda control unit that executes control so as to consecutively perform treatment processes of the same contents for a plurality of samples by comparing individual process sequences, each including a plurality of treatment processes performed for each of the samples, with each other.20. The automatic tissue staining device according to claim 19 , further comprising a horizontal direction movement unit that moves the supply head in a horizontal direction claim 19 , wherein:one or more of the glass slides are situated in a first region,one or more of the glass slides are situated in a second region different from the first region,the control unit makes a comparison between a usage schedule of the horizontal direction movement unit in a treatment for one or more first samples on the one or more glass slides situated in the first region and a usage schedule of the horizontal direction movement unit in a treatment for one or more second samples on the ...

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Номер записи: 54
23-01-2020 дата публикации

AUTOMATED METHODS AND SLIDE PROCESSING APPARATUSES

Номер: US20200025655A1
Автор: Hassen Charles Nathan, Thompson Michael J.
Принадлежит:

A system is capable of detecting substrates and can differentiate between zero, one, or multiple transparent or semi-transparent substrates in a stack. The system can include an optical sensor, an optically anti-reflective element, and a detector. The optical sensor outputs light towards the optically anti-reflective element. The light detector is positioned to detect light from the light source that is reflected by substrates, if any, positioned within a detection zone between the optically anti-reflective element and the detector. 137-. (canceled)38. A method for detecting substrates using a transparent substrate detector device with a detection zone , the method comprising:robotically carrying one or more substrates toward the detection zone;outputting light toward the one or more substrates at the detection zone such that at least a portion of the outputted light is reflected by the one or more substrates and another portion of the outputted lighted is transmitted through the one or more substrates;detecting the outputted light that is reflected by each of the one or more substrates; anddetermining a number of substrates at the detection zone based on the detected outputted reflected light.39. The method of claim 38 , wherein determining the number of substrates includes determining (a) whether the one or more substrates carried to the detection zone includes a single substrate only and/or (b) whether the one or more substrates includes multiple substrates.40. The method of claim 38 , further comprising:determining a detection signal corresponding to an intensity of the detected outputted light;comparing the detection signal to a reference signal, which corresponds to absence of substrate(s) at the detection zone; andwherein determining the number of substrates at the detection zone is based on the comparison of the detection signal to the reference signal.41. The method of claim 38 , further comprising substantially eliminating detection of the another portion ...

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Номер записи: 55
04-02-2016 дата публикации

System and methods for automated vitrification of biological materials

Номер: US20160029619A1
Автор: Jun Liu, Yu Sun
Принадлежит: University of Toronto

The present invention relaters to a system and methods for automated vitrification of mammalian oocytes or embryos. The system and methods enable automated processing of oocytes or embryos in vitrification solutions; robotically moving vitrification devices that carry processed cells for freezing in liquid nitrogen; automated sealing of the frozen devices; and transferring the sealed devices to an automated storage system for long-term cryopreservation.

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Номер записи: 56
02-02-2017 дата публикации

TAPE ADAPTOR

Номер: US20170028399A1
Автор: Peterson Bruce, Urke Brent
Принадлежит: Douglas Scientific, LLC

A tape adaptor () includes a bottom plate () and a top plate () mounted to the bottom plate () with a space () defined between an upper side wall () of the bottom plate () and a lower face () of the top plate () for receiving a tape segment () remaining on or cut from a continuous array tape (). The tape segment () includes an array of wells () between two edges (). A slit () is formed between an end () of the top plate () and an end () of the bottom plate (). The tape segment () is slideably extended through the slit () into the space () with the edges () sliding on two ridges () on two longitudinal edges () of the bottom plate (). The bottom plate () can include at least one groove () to receive the array of wells () of the tape segment (). The tape segment () is positioned relative to the tape adaptor () by the ridges () or the groove (). 1. A microtiter plate comprising , in combination:a bottom plate having first and second ends spaced in a first direction and upper and lower side walls extending between the first and second ends, with the upper and lower side walls spaced in a second direction perpendicular to the first direction, with the bottom plate further including first and second longitudinal edges extending between the first and second ends and spaced in a third direction perpendicular to the first and second directions, a first ridge extending from the first longitudinal edge and extending away from the lower side wall of the bottom plate in the second direction, and extending substantially from the first end to the second end, and a second ridge extending from the second longitudinal edge and extending away from the lower side wall of the bottom plate in the second direction, and extending substantially from the first end to the second end, with the first and second ridges being spaced in the third direction;a top plate including first and second ends spaced in the first direction and upper and lower faces extending between the first and second ends ...

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Номер записи: 57
02-02-2017 дата публикации

Relative Humidity Control Apparatus

Номер: US20170030937A1
Автор: ASCHWANDEN Marcel, BECKER Erna, Fink Pius, LOOSER Werner, TANNER Fredy
Принадлежит: TECAN SCHWEIZ AG

A relative humidity control apparatus for control of the relative humidity in a gas space has a nebulizer source with an outlet for nebulized liquid, a frame surrounding an open area and comprising an opening arrangement to the open area and in operational flow connection with the outlet, and a flow drive arrangement generating a gas flow from the outlet to and out of the opening arrangement. A liquid handling robot comprising this apparatus, a method of operating the apparatus, an immunoassay method and methods of controlling the time course of the relative humidity in a gaseous space and of producing a predetermined volume of a liquid are also disclosed. 21020. The control apparatus of claim 1 , said nebulizer source comprising a container () and an ultrasonic nebulizer arrangement () operationally connected to said container.35012331110. The control apparatus of one of claims 1 , said flow drive arrangement () comprising a pressure source generating a pressure gradient from said outlet () to said open space via said opening arrangement () claims 1 , preferably a blower claims 1 , preferably with a blower output operationally connected to an input opening () to said container ().410034. The control apparatus () according to claim 1 , wherein said groove () extends all along said frame.5100141233. The control apparatus () according to further comprising a second container () flow-interconnected between said outlet () and said opening arrangement ().6100. The control apparatus () according to claim 1 , wherein the frame defines a plane and is preferably substantially circular or substantially rectangular.7100. The control apparatus () according to claim 1 , wherein said open space is one-side limited by a wall one of adjacent to and of on said frame claim 1 , said wall comprising preferably a titer plate with wells exposed to said open space.8100. The control apparatus () according to claim 1 , comprising a holder for an exchangeable plate said plate on said holder ...

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Номер записи: 58
01-02-2018 дата публикации

SMEAR TRANSPORTING APPARATUS, SMEAR SYSTEM, AND SMEAR PREPARING APPARATUS

Номер: US20180031454A1
Автор: NAKAJIMA Takayuki, Oda Tetsuya, ONOMICHI Hiromi, SHINABE Seiya, TSURUMI Kentaro
Принадлежит: SYSMEX CORPORATION

A smear system includes smear preparing apparatus that prepares a smear slide and a smear transporting apparatus that transports the smear slide to a smear-image capture apparatus. The smear preparing apparatus includes: a smear preparation part that smeares a sample on a slide; and a smear arrangement part that places smear slides in a smear container. The smear transporting apparatus includes: a smear-container transport part that transports the smear container with the smear slides; an identification-information acquisition part that acquires identification information on whether image capturing by the smear-image capture apparatus is necessary, from each of the smear slides accommodated in the smear container positioned on a transport path of the smear-container transport part; and a smear transfer part that transfers the smear slide whose image is to be captured to the smear-image capture apparatus on the basis of the identification information acquired by the identification-information acquisition part. 1. A smear system comprising:a smear preparing apparatus that prepares a smear slide on which a sample is smeared; anda smear transporting apparatus that transports the smear slide prepared by the smear preparing apparatus to a smear-image capture apparatus, wherein a smear preparation part that prepares the smear slide by smearing a sample on a slide; and', 'a smear arrangement part that places, in a smear container, smear slides including a smear slide whose image is to be captured by the smear-image capture apparatus and a smear slide whose image is not to be captured by the smear-image capture apparatus, and, 'the smear preparing apparatus comprises a smear-container transport part that transports the smear container with the smear slides placed by the smear arrangement part;', 'an identification-information acquisition part that acquires identification information on whether image capturing by the smear-image capture apparatus is necessary, from each of ...

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Номер записи: 59
17-02-2022 дата публикации

VACUUM TRANSFER FOR NANO INDENTER AND SAMPLE MEASUREMENT METHOD USING THE SAME

Номер: US20220050026A1
Автор: AHN Jae Pyoung, BAEK Woo Suk, HONG Jihyun, KANG Inyeong, Kim So Hee
Принадлежит:

There are provided a vacuum transfer system installed in an microscope to prevent oxidation of a sample and a sample measurement method using the vacuum transfer system. The vacuum transfer system according to an embodiment is a vacuum transfer system installed in an microscope to prevent oxidation of a sample, and includes a housing having an open surface, wherein the surface has a coupling element for attaching or detaching to/from the microscope, and an inside of the housing is kept closed from outside as the housing is coupled with the microscope through the coupling element, a gas inlet through which an inert gas is introduced into the housing, a gas outlet through which an active gas in the housing exits with the introduction of the inert gas into the housing, and at least one glove formed to be connected with the inside of the housing. 1. A vacuum transfer system installed in an microscope to prevent oxidation of a sample , the vacuum transfer system comprising:a housing having an open surface, wherein the surface comprises a coupling element for attaching or detaching to/from the microscope, and an inside of the housing is kept closed from outside as the housing is coupled with the microscope through the coupling element;a gas inlet through which an inert gas is introduced into the housing;a gas outlet through which an active gas in the housing exits with the introduction of the inert gas into the housing; andat least one glove formed to be connected with the inside of the housing.2. The vacuum transfer system according to claim 1 ,wherein the gas inlet is disposed in a first side surface of the housing, andthe gas outlet is disposed in a second side surface of the housing opposite the first side surface of the housing.3. The vacuum transfer system according to claim 2 ,wherein a plurality of gloves is formed, andthe gloves include a first glove disposed in the first side surface and a second glove disposed in the second side surface.4. The vacuum transfer ...

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Номер записи: 60
31-01-2019 дата публикации

Bio-fluid analysis and reporting system and method

Номер: US20190033288A1
Автор: Asghar David MOSTAFA, Joseph KRALOWETZ, Joseph Roesch, Michael Giovannoni, Roland Probst, Sean Higgins, Thomas Joseph Brown
Принадлежит: RUBRIQ CORP

A system and method for analyzing bio-fluid constituents and properties in a bio-fluid sample, wherein the system comprises a bio-fluid collection apparatus, a bio-fluid testing/analysis apparatus, and a reporting apparatus.

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Номер записи: 61
11-02-2016 дата публикации

Microfluidic device

Номер: US20160038939A1
Автор: Jong Gun Lee, Jung Ki Min, Seung Jun Lee, Yong Hyun Kim, Young Goun Lee
Принадлежит: SAMSUNG ELECTRONICS CO LTD

Provided is a microfluidic device having a structure in which scattering of a sample can be prevented. The microfluidic device includes: a platform including: a sample injection hole, at least one chamber configured to accommodate a sample introduced through the sample injection hole, at least one channel connected to the at least one chamber; and a cover disposed over the sample injection hole, wherein a gap is disposed between the sample injection hole and the cover.

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Номер записи: 62
11-02-2016 дата публикации

METHOD FOR OPERATING A SYSTEM FOR THE INTEGRATED AND AUTOMATED ANALYSIS OF DNA OR PROTEIN

Номер: US20160041193A1
Автор: Gumbrecht Walter, Paulicka Peter
Принадлежит: BOEHRINGER INGELHEIM VETMEDICA GMBH

A method for the integrated and automated analysis of DNA or protein, including a single-use cartridge, with an analysis device having a control device, and devices for capturing and processing signals, the control device carrying out a completely automatic process and evaluation of molecular diagnostic analysis via single-use cartridges (Lab-on-a-Chip). Controlling of an analysis process, which occurs in the cartridge, involve the subsequent displacement and thermostatisation of liquids with a first device, and with a second device the signals which are obtained during the analysis are processed. The first and the second devices are synchronized in such a manner that the analysis process of the sample can be carried out in a totally integrated manner thus producing an immediate result. 2. The method as claimed in claim 1 , wherein the carrying out the analysis includes performing a DNA analysis claim 1 , and the DNA analysis includes cell disruption and PCR.3. The method as claimed in claim 2 , comprising the further steps of:opening the cartridge receptacle and using the pump to draw water from the reservoir given a suitable valve position;inserting, via a user, the cartridge with a sample;automatically starting the analysis;pumping water into the cartridge via a water port to wash out the excess sample material;diluting, as a result of the inflow of water, the sample and pumping it into the cell disruption channel, wherein dry reagents are dissolved, wherein a residence time ensues for cell disruption, and wherein liberated DNA binds to magnetic beads;filing, at the same time two ELISA reagent channels, wherein dry ELISA reagents are dissolved;flushing the content of the cell disruption channel by further pumping of water through the PCR chamber, wherein the magnetic beads with DNA are held back by a magnetic field, the remainder is flushed into a waste channel;closing off the valves of the PCR chamber;starting the thermocycling, wherein dry PCR reagents are ...

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Номер записи: 63
08-02-2018 дата публикации

ROTORS FOR IMMUNOASSAYS

Номер: US20180038853A1
Автор: Aron Kenneth P., MEHRA Rajesh K.
Принадлежит:

The present invention provides an analyte detection system for detecting target analytes in a sample. In particular, the invention provides a detection system in a rotor or disc format that utilizes a centrifugal force to move the sample through the detection system. Methods of using the rotor detection system to detect analytes in samples, particularly biological samples, and kits comprising the rotor detection system are also disclosed. 1. A method for detecting an analyte in a sample comprising(i) adding the sample to a sample port of a device comprising the sample port and a surface, wherein the surface comprises at least one channel and an immobilized capture ligand capable of specifically binding to an analyte in a sample and wherein the sample port is in fluid communication with said at least one channel and immobilized capture ligand,(ii) spinning the surface and the sample port about a fixed axis to generate a centrifugal force, wherein the centrifugal force causes the sample added to the sample port to flow through the channel and come into fluid contact with the capture ligand, and(iii) detecting the binding of the analyte in the sample to the capture ligand.2. The method of claim 1 , wherein the channel comprises a conjugate capable of binding to the analyte in the sample claim 1 , wherein the conjugate is located upstream of the immobilized capture ligand such that claim 1 , when the centrifugal force causes the sample to flow through the channel the conjugate binds to the analyte in the sample to form a complex claim 1 , and wherein the complex is captured by the capture ligand when the centrifugal force causes the sample to come into fluid contact with the capture ligand.3. The method of claim 2 , wherein the conjugate comprises a binding partner conjugated to a detectable entity.4. The method of claim 3 , wherein the detectable entity is a metallic nanoparticle or metallic nanoshell.5. The method of claim 4 , wherein the detectable entity is selected ...

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Номер записи: 64
06-02-2020 дата публикации

ROTATABLE CARTRIDGE FOR PROCESSING AND ANALYZING A BIOLOGICAL SAMPLE

Номер: US20200038858A1
Автор: Boehm Christoph, Lutz Sascha, Spinke Juergen
Принадлежит:

An automatic analyzer cartridge, spinnable about a rotational axis, has fluid and aliquoting chambers, a metering chamber connected to a vent that is nearer to the rotational axis than the metering chamber, first and second ducts connecting the fluid and aliquoting chambers, and the metering and aliquoting chambers, respectively. Metering chamber side walls taper away from a central region, wherein capillary action next to the walls is greater than in the central region. Fluid flows to the metering chamber using capillary action via the second duct that has an entrance and exit in the aliquoting and metering chambers, respectively; the exit being closer to the rotational axis than the entrance. A downstream fluidic element connects to the metering chamber via a valve. A fluidic structure receives and processes a biological sample into the processed biological sample and has a measurement structure that enables measurement of the processed biological sample. 1. A method of repeatedly dispensing measured amounts of a fluid using a cartridge , wherein the cartridge is operable for being spun around a rotational axis , wherein the cartridge comprises:a metering chamber, wherein the metering chamber is operable for causing fluid to fill the metering chamber using capillary action, wherein the metering chamber has side wall regions and a central region, wherein the side wall regions are narrower than the central region in a cross sectional view of the metering chamber, wherein capillary action next to the side wall regions of the metering chamber is greater than in the central region of the metering chamber; anda duct connected to the metering chamber, wherein the duct comprises a duct entrance and a duct exit in the metering chamber, the duct exit being closer to the rotational axis than the duct entrance, wherein the duct is operable for causing fluid to flow to the metering chamber using capillary action, wherein the method comprises:decreasing a rotational rate of the ...

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Номер записи: 65
12-02-2015 дата публикации

DEVICE AND METHOD FOR CONTROLLING THE TEMPERATURE IN A MOVING FLUID IN A LABORATORY SAMPLE PROCESSING SYSTEM

Номер: US20150044664A1
Автор: KELLAND James, Nguyen Nhat Khai L., SULLIVAN Kevin J.
Принадлежит:

A temperature control device and method are provided for an analytical system for performing laboratory protocols. The device includes a well within a housing configured to receive a biological specimen according to a predetermined sample process. The specimen is suspended by a holding device in the well. A thermal element is provided in heat exchange communication with fluid in the well. A temperature sensor is located in the well at a location to be covered and uncovered by rocking motion of fluid in the well. A controller, in communication with the thermal element, the temperature sensor, and an agitation system, is operative to control the thermal element in correlation with temperature data, for example, peak temperature data, from the temperature sensor. 1. A temperature control device comprising:a housing, a well within the housing configured to receive an object, at least one fluid port in the housing configured to provide fluid access to the well;a thermal element in heat exchange communication with fluid in the well;a temperature sensor disposed in the well at a location to be covered and uncovered by fluid in the well as the housing portion moves;an agitation system coupled to at least a portion of the housing to cause fluid flow within the well; anda controller in communication with the thermal element, the temperature sensor, and the agitation system and operative to control the thermal element in correlation with temperature readings from the temperature sensor and movement of the agitation system.2. The device of claim 1 , wherein the thermal element comprises a surface of the housing forming a portion of the well.3. The device of claim 1 , wherein the thermal element is thermally coupled to a surface of the housing.4. The device of claim 1 , wherein the thermal element is thermally coupled to a floor of the well.5. The device of claim 1 , wherein the thermal element comprises a Peltier device thermally coupled to a surface of the housing.6. The ...

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Номер записи: 66
06-02-2020 дата публикации

IMPROVEMENTS IN AND RELATING TO MAGAZINES FOR HOLDING PLURAL FLAT CARDS

Номер: US20200039693A1
Автор: EVANS Phillip, LAMERTON Kathryn Louise, Smith Michael John, SWANN Kristina
Принадлежит:

Disclosed is a lidded magazine () for holding plural generally flat sample collection cards () in spaced parallel relation, the magazine is open at its top and includes upstanding opposed side walls (), each wall () further including plural opposed pairs of inwardly extending wall ribs () spaced along each wall () to provide therebetween card accepting slots, a first slot dimension (W) being defined by the spacing between an interior face () of each wall, the magazine being characterised in that the walls () at the top () of each slot () are tapered outwardly such that the first dimension (W) is greatest at the top of the slot (). 110010110120110120112122110120154110120152150150. A magazine () for holding plural generally flat sample collection cards () in spaced parallel relation at their edges only , the magazine open at its top and including upstanding opposed side walls ( ,) , each wall ( ,) further including plural opposed pairs of inwardly extending wall ribs ( ,) spaced along each wall ( ,) to provide therebetween card accepting slots , a first slot dimension (W) being defined by the spacing between an interior face () of each wall , the magazine being characterised in that the walls ( ,) at the top () of each slot () are tapered outwardly such that the first dimension (W) is greatest at the top of the slot ().2152. A magazine as claimed in claim 1 , wherein the side walls have a thickness (D) which tapers toward the top () of the walls claim 1 , to provide said enlarged first dimension (W).3112122130110120134132150. A magazine as claimed in or claim 1 , wherein the wall ribs ( claim 1 ,) have a cross piece () extending generally in the same direction as a respective wall ( claim 1 ,) claim 1 , wherein claim 1 , adjacent ends () of neighbouring cross pieces are spaced to define a gap which gap defines a second slot dimension (T) said cross pieces having a narrowing upper end () such that the second dimension (T) is enlarged at the top of the slot ().4. A ...

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Номер записи: 67
07-02-2019 дата публикации

Automated Smear Making Apparatus

Номер: US20190041299A1
Автор: Chacko Koshy T., Shoffner John Scott, Solomon Roei
Принадлежит:

An automated smear making apparatus used to prepare and smear samples on glass slides. In one embodiment, there is provided a smearing subsystem that generally includes a smear cartridge having: an input reel; at least one roll bar; a take-up reel; and a smearing tape. The smearing tape is initially wound within the input reel and coupled to the take-up reel such that the smearing tape can be drawn from the input reel and into the take-up reel. The smearing tape may include a plurality of perforations formed therein. The smearing tape may then be wrapped around the roll bar such that each of the plurality of perforations forms a blade that extends from the smearing tape to expose a smear surface as the smearing tape is drawn into the take-up reel. Alternatively, the smearing tape may be bent such that an edge of the smearing tape forms a smear surface between two roll bars. A slide transport surface is also provided to move a slide across the smear surface. 129-. (canceled)30. A smearing subsystem for use in an automated slide preparation apparatus , the smearing subsystem comprising: an input reel;', 'a take-up reel;', 'a smearing tape comprising a smear surface included on a blade of a cut-out of the smearing tape; and', 'a deflection component configured to deflect the smearing tape cut-out to create the blade., 'a) a smear cartridge including'}31. The smearing subsystem of claim 30 , wherein the blade extends from the smearing tape to expose the smear surface as the smearing tape is drawn from the input reel and into the take-up reel.32. The smearing subsystem of claim 31 , further comprising a slide transport surface configured to move a slide across the exposed smear surface.33. The smearing subsystem of claim 32 , wherein the exposed smear surface of the blade forms a contact angle with the slide when the slide transport surface brings the slide in contact with the exposed smear surface such that the contact angle formed between the smear surface and the ...

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Номер записи: 68
07-02-2019 дата публикации

SYSTEMS AND METHODS FOR AUTOMATED PREPARATION OF BIOLOGICAL SPECIMENS

Номер: US20190041302A1
Автор: Cordeiro Michael, Grimes Eric, Hunt Barry F., Jenoski Raymond, Oliva Ryan
Принадлежит: Hologic, Inc.

An automated system for processing a sample contained in a liquid sample container includes an automated tool head configured to rotate about a first axis, and to translate along a second axis different than the first axis, an analytic element positioner having an analytic element holder configured to releasably grip an analytic element, and a specimen transfer device carried by the tool head, wherein the tool head is configured to automatically position a working end of the specimen transfer device to obtain a specimen from a sample container held in the sample container holder, and to transfer the obtained specimen to an analytic element held by the analytic element holder, respectively, through one or both of rotation of the tool head about the first axis and translation of the tool head along the second axis. 1. An automated system for processing a sample contained in a liquid sample container , the system comprising:a sample container holder configured for holding a sample container;an automated tool head configured to rotate about a first axis, and to translate along a second axis different than the first axis;a first capping device disposed on the tool head and configured to controllably grip and release a cap of a sample container held in the sample container holder, wherein the tool head is configured to automatically position the first capping device proximate the sample container cap through one or both of rotation of the tool head about the first axis and translation of the tool head along the second axis, and wherein the first capping device operatively cooperates with the sample container holder to remove or install the sample container cap;an analytic element positioner having an analytic element holder configured to releasably grip an analytic element; anda specimen transfer device carried by the tool head, wherein the tool head is configured to automatically position a working end of the specimen transfer device to obtain a specimen from a sample ...

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Номер записи: 69
07-02-2019 дата публикации

FULLY AUTOMATIC TEST CARD CONVEYING APPARATUS FOR INSTANT TESTING INSTRUMENT

Номер: US20190041413A1
Автор: Chen Xiaodong, HONG Longbin, Hu Rui, SHEN Guojin, Xu Wenjie, ZHOU Songbing, ZHOU Xuyi
Принадлежит:

A fully automatic test card conveying apparatus for an instant testing instrument is used for conveying a test card and includes a test card conveying arm, frame, push rod, buffer support, buffer cartridge, and card extraction mechanism. A first electric motor, second electric motor, first sliding rail, and second sliding rail are provided on the arm. The frame is connected in a sliding manner to the first sliding rail via a sliding block, and connected to the first electric motor via a first synchronization belt. A stepping motor is provided on the sliding block and an output end of the stepping motor is connected to the frame. The push rod is connected in a sliding manner with the second sliding rail, and connected to the second electric motor via a second synchronization belt. 1. A fully automatic test card conveying apparatus for an instant testing instrument is used for conveying a test card , comprising:a test card conveying arm;a frame;a push rod;a buffer support;a buffer cartridge; anda card extraction mechanism,wherein a first electric motor, a second electric motor, a first sliding rail and a second sliding rail are provided on the test card conveying arm, the frame is connected in a sliding manner to the first sliding rail via a sliding block, and is connected to the first electric motor via a first synchronization belt, a stepping motor is provided on the sliding block, and an output end of the stepping motor is connected to the frame, wherein the buffer support is arranged on one side of the test card conveying arm, provided with a third motor and a third sliding rail, the buffer cartridge is connected with the third sliding rail in a sliding manner and connected to the third electric motor via a third synchronization belt, the card extraction mechanism is arranged on the frame, and wherein a holder block is arranged on the test card conveying arm.2. The fully automatic test card conveying apparatus for an instant testing instrument according to claim 1 ...

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Номер записи: 70
16-02-2017 дата публикации

Systems and methods for facilitating fluid flow during enhanced detection and quantification of analytes

Номер: US20170043334A1
Автор: Ayub Khattak, Clinton Sever, Justin Demartino, Mark Duncan, Paul Nelson, Raphael Shapiro, Ryan Cooper, Thomas Congdon
Принадлежит: Cue Health Inc

Devices, systems, and methods for detecting molecules of interest within a collected sample are described herein. In certain embodiments, self-contained sample analysis systems are disclosed, which include a reusable reader component, a disposable cartridge component, and a disposable sample collection component. The reader component may communicate with a remote computing device for the digital transmission of test protocols and test results. In various disclosed embodiments, the systems, components, and methods are configured to identify the presence, absence, and/or quantity of particular nucleic acids, proteins, or other analytes of interest, for example, in order to test for the presence of one or more pathogens or contaminants in a sample.

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Номер записи: 71
16-02-2017 дата публикации

Cartridges, collectors, kits, and methods for enhanced detection and quantification of analytes in collected fluid samples

Номер: US20170043335A1
Автор: Ayub Khattak, Clinton Sever, Justin Demartino, Mark Duncan, Paul Nelson, Raphael Shapiro, Ryan Cooper, Thomas Congdon
Принадлежит: Cue Health Inc

Devices, systems, and methods for detecting molecules of interest within a collected sample are described herein. In certain embodiments, self-contained sample analysis systems are disclosed, which include a reusable reader component, a disposable cartridge component, and a disposable sample collection component. The reader component may communicate with a remote computing device for the digital transmission of test protocols and test results. In various disclosed embodiments, the systems, components, and methods are configured to identify the presence, absence, and/or quantity of particular nucleic acids, proteins, or other analytes of interest, for example, in order to test for the presence of one or more pathogens or contaminants in a sample.

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Номер записи: 72
06-02-2020 дата публикации

WASTE RAMP FOR REAGENT CARDS

Номер: US20200041482A1
Автор: Galano Kenneth, Parker Michael, Tang Aaron Sung-Lien
Принадлежит: SIEMENS HEALTHCARE DIAGNOSTICS INC.

An automated analyzer for reagent cards having a leading end, a trailing end and a length between the leading end and the trailing end comprises a travel surface assembly having a card travel surface and an edge. A test analyzing mechanism is adjacent to the travel surface, and a waste receptacle is adjacent to the edge below the travel surface. The waste receptacle has a side and a waste cavity. A ramp member positioned below the travel surface has an end and a sloped surface, and is movable between an extended position where the sloped surface extends into the waste cavity, and a retracted position where the end is spaced from the side a distance greater than the length of the reagent card. A moving mechanism operably coupled with the ramp member is configured to move the ramp member between the extended position and the retracted position. 115.-. (canceled)16. A method , comprising:attaching a ramp member to a mover assembly of an automated analyzer such that the mover assembly is configured to simultaneously advance a reagent card along a card travel surface and extend the ramp member into a waste cavity of a waste receptacle.17. The method of claim 16 , wherein the mover assembly is configured to grip the reagent card.18. The method of claim 16 , further comprising attaching a comb to a support located adjacent to a waste receptacle such that a ridge of the comb extends above the ramp member and overlaps the ramp member when the ramp member is extended into the waste cavity. The entirety of U.S. Provisional Application Ser. No. 61/576,394, filed on Dec. 16, 2011, is hereby expressly incorporated herein by reference.The inventive concepts disclosed herein generally relate to analyzers for multiple-profile reagent cards, and more particularly, but not by way of limitation, to a waste ramp configured to stack used reagent cards during the operation of automated reagent card analyzers.To satisfy the needs of the medical profession as well as other expanding ...

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Номер записи: 73
06-02-2020 дата публикации

PLATE CHANGER FOR AUTOSAMPLER

Номер: US20200041531A1
Автор: SAWADA Takuya
Принадлежит: SHIMADZU CORPORATION

A plate changer includes a plate storage that includes therein a plate setting base, and is provided with a transport window for retrieving, in one direction in a horizontal plane, a sample plate set on the plate setting base; and a transport mechanism that has at least a pair of holding portions holding both side surfaces of a sample plate, and holds and transports the sample plate by the holding portions. The plate storage has a plate guide that supports a side surface of the sample plate set on the plate setting base and guides the sample plate to a predetermined setting position. When the holding portion is inserted into the plate storage from the transport window, the plate guide is configured to move to a position not interfering with the action of the holding portion. 16-. (canceled)7. A plate changer for an autosampler comprising:a plate storage that includes therein a plate setting base for setting a sample plate, and is provided with a transport window for retrieving, in one direction in a horizontal plane, a sample plate set on the plate setting base; anda transport mechanism that has at least a pair of holding portions for holding both side surfaces, which are parallel to the one direction, of a sample plate, and configured to hold the sample plate set on the plate setting base by the holding portions and to transport the sample plate,wherein the plate storage has a plate guide for supporting at least one of both the side surfaces of the sample plate set on the plate setting base so that the sample plate is led to a predetermined setting position on the plate setting base, andthe plate guide is configured to move from a position interfering with the holding portion to a position not interfering with the action of the holding portion when the holding portion is inserted into the plate storage through the transport window.8. The plate changer according to claim 7 , wherein the plate guide is provided to support both the side surfaces of the sample plate ...

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Номер записи: 74
18-02-2016 дата публикации

System for operating a system for the integrated and automated analysis of dna or protein

Номер: US20160047832A1
Автор: Peter Paulicka, Walter Gumbrecht
Принадлежит: BOEHRINGER INGELHEIM VETMEDICA GMBH

A system for the integrated and automated analysis of DNA or protein, including a single-use cartridge, with an analysis device having a control device, and devices for capturing and processing signals, the control device carrying out a completely automatic process and evaluation of molecular diagnostic analysis via single-use cartridges (Lab-on-a-Chip). Controlling of an analysis process, which occurs in the cartridge, involves the subsequent displacement and thermostatisation of liquids with a first device, and with a second device the signals which are obtained during the analysis are processed. The first and the second devices are synchronized in such a manner that the analysis process of the sample can be carried out in a totally integrated manner thus producing an immediate result.

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Номер записи: 75
16-02-2017 дата публикации

WASHING/DRYING APPARATUS, SCREENING APPARATUS, WASHING/DRYING METHOD, AND SCREENING METHOD

Номер: US20170045543A1
Автор: Hamashima Muneki, ISAMI Tadao, UEDA Takehiko
Принадлежит: NIKON CORPORATION

There is a possibility that an arrangement of a cleaning device and a drying device may result in an inefficient usage of a space for an installation. A cleaning and drying apparatus for a plate including a biochip is provided with: a cleaning device that is configured to clean the plate ; and a drying device that is configured to dry the plate , the drying device is arranged above the cleaning device 1. A cleaning and drying apparatus for a plate having a biochip. a cleaning part that is configured to clean the plate; and', 'a drying part that is configured to dry the plate,', 'the drying part being arranged above the cleaning part., 'the cleaning and drying apparatus comprising2. The cleaning and drying apparatus according to claim 1 , whereinthe cleaning part is configured to clean the plate in an upright condition,the drying part is configured to dry the plate in an upright condition.3. The cleaning and drying apparatus according to comprising a transporting part that is configured to upwardly transport the plate cleaned by the cleaning part to the drying part.4. The cleaning and drying apparatus according to claim 3 , whereinthe transporting part is configured to downwardly transport the uncleaned plate to the cleaning part while allowing the uncleaned plate to pass through the drying part.5. The cleaning and drying apparatus according to claim 3 , whereinthe transporting part is configured to transport the plate in a vertical direction from the cleaning part to the drying part at an upper side.6. The cleaning and drying apparatus according to claim 1 , whereinthe drying part is arranged above the cleaning part in a vertical direction.7. The cleaning and drying apparatus according to claim 1 , whereinthe cleaning part is configured to clean both surfaces of the plate,the drying part is configured to dry both surfaces of the plate.8. The cleaning and drying apparatus according to comprising a circulating mechanism that is configured to filter exhaust air from ...

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Номер записи: 76
03-03-2022 дата публикации

Automatic specimen feeding system and control method therefor

Номер: US20220065887A1
Автор: Gwan Hoon YOON
Принадлежит: APM ENGINEERING Co Ltd

The present invention relates to an automatic specimen feeding system and a control method therefor, the automatic specimen feeding system comprising: a main frame installed adjacent to a carbon measuring apparatus, having a space with an open upper portion, and being provided with an input hole for inputting a specimen into the carbon measuring apparatus; a specimen seating unit which reciprocates horizontally in a direction perpendicular to the carbon measuring apparatus while moving up and down with respect to the main frame, and on which a plurality of specimens can be seated; a specimen lift unit which is installed under the specimen seating unit and can lift one of the plurality of specimens seated on the specimen seating unit; and a specimen input unit which is installed lengthways in the direction towards the carbon measuring apparatus to grip specimens lifted by the specimen lift unit and to input the specimens into the carbon measuring apparatus. Therefore, a plurality of specimens can be automatically input into the carbon measuring apparatus and used specimens can be discarded without using manpower, and thus user convenience can be improved. In addition, processes of inputting specimens can be minimized to noticeably reduce the time taken to automatically measure carbon by using specimens.

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Номер записи: 77
23-02-2017 дата публикации

ROTATABLE CARTRIDGE FOR MEASURING A PROPERTY OF A BIOLOGICAL SAMPLE

Номер: US20170050185A1
Автор: Boehm Christoph, Dolbinow Thomas, Lutz Sascha
Принадлежит:

A cartridge for an automatic analyzer, formed from a cover and carrier structure, is operable for rotation about an axis and has at least one container with at least one reservoir containing at least one fluid. Each container may rotate about the axis within a cavity and relative to the carrier structure. A piercing structure opens a seal of each reservoir when the container rotates relative to the carrier structure. Each container and each cavity has a frictional element that mate and cause friction. Each container has an engaging surface which mates with an engaging surface of a rotational actuator that applies torque to rotate and open the container via the piercing structure. A fluidic structure of the cartridge processes a biological sample into a processed biological sample and enables via a measurement structure measurement of the processed biological sample. A duct is between the cavity and the fluidic structure. 1. A method of performing a measurement of a processed biological sample using a cartridge that is operable for being spun around a rotational axis , the cartridge comprising a carrier structure , a cover provided to the carrier structure , at least one container with at least one fluid reservoir for containing at least one fluid , and a cavity for each of the at least one cartridge , wherein the cavity is formed from the carrier structure and the cover , the at least one container is configured to rotate about the rotational axis of the cartridge within the cavity and relative to the carrier structure , each of the at least one fluid reservoir comprises a pierceable seal , at least one piercing structure for each of the at least one fluid reservoir provided within the cavity , the at least one piercing structure is configured to open the pierceable seal by piercing the pierceable seal upon rotation of the at least one container relative to the carrier structure , the at least one container comprises a first frictional element , a second frictional ...

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Номер записи: 78
25-02-2016 дата публикации

In-vitro diagnostic apparatus and in-vitro diagnostic test method

Номер: US20160054342A1
Автор: Ki-Ju Lee, Yu-ri SON
Принадлежит: SAMSUNG ELECTRONICS CO LTD

An in-vitro diagnostic apparatus includes a controller configured to set a test result reference range corresponding to a condition of a testee, among test result reference ranges corresponding to a plurality of conditions, with respect to a test item of a test object, and generate a user interface screen including the set test result reference range; and a display configured to display the user interface screen.

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Номер записи: 79
25-02-2021 дата публикации

BIOLOGICAL INFORMATION DETECTION SENSOR FEEDING APPARATUS

Номер: US20210055281A1
Автор: YASUI Shinichi
Принадлежит:

The biological information detection sensor supply device is provided with a main body case having a supply port to which a biological information measurement device can be attached, a housing unit for housing a biological information detection sensor and a sensor supply film including a cover film and a holding film for sandwiching the biological information detection sensor, and a supply unit for supplying the biological information detection sensor from the housing unit to the supply port. The supply unit supplies the biological information detection sensor to the supply port, and separates the holding film and the cover film from the sensor supply film in a state before the biological information detection sensor is supplied to the supply port. At the supply unit, the biological information detection sensor supplied to the supply port is fitted to the biological information measurement device fitted to the supply port. 113-. (canceled)14. A biological information detection sensor feeding apparatus comprising:a body case having a loading opening configured such that a biological information measurer can be attached thereto;a storage section that stores a plurality of biological information detection sensors in the body case; anda feeding section that feeds one of the biological information detection sensors from the storage section to the loading opening, whereinthe loading opening has a connector connected with the biological information measurer;the biological information detection sensor has a connection electrode;the feeding section is configured to feed the biological information detection sensor to the loading opening such that the connecting electrode of the biological information detection sensor is electrically connected with the connecter of the loading opening.15. The biological information detection sensor feeding apparatus according to claim 14 , wherein:the biological information detection sensor has a spot-application portion for spotting a ...

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Номер записи: 80
25-02-2021 дата публикации

SLIDE INVENTORY AND REINSERTION SYSTEM

Номер: US20210055317A1
Автор: DJELOSEVIC Prentash, NAJMABADI Peyman, NEWBERG Nicholas, STEARRETT Aaron
Принадлежит:

A slide rack inventory and reinsertion system for use with a digital slide scanning apparatus is provided that determines, prior to scanning of glass slides in a slide rack, a status of each slot in the slide rack as properly occupied, improperly occupied, or empty. The system also determines whether a slide that has been removed from the slide rack for processing has been properly reinserted into the slide rack. 1. A digital slide scanning apparatus comprising:a sensor comprising a sensor mount with a transmitter element on a first side of the sensor mount, a receiver element on a second side of the sensor mount, and an open space between the first side and the second side of the sensor mount, wherein the transmitter element and the receiver element are positioned for line-of-sight communication across the open space;a motor configured to move a slide rack along a linear axis, such that at least a portion of the slide rack passes through the open space between the first side and the second side of the sensor mount, wherein the loaded slide rack comprises a plurality of slots, and wherein each of the plurality of slots is configured to hold a slide; and control the motor to move the slide rack along the linear axis, and', 'analyze a signal, output by the sensor during the movement of the slide rack along the linear axis, to determine the status of each of the plurality of slots in the slide rack., 'at least one processor configured to'}2. The digital slide scanning apparatus of claim 1 , wherein the sensor mount comprises a first arm on the first side and a second arm on the second side claim 1 , wherein the transmitter element is positioned on the first arm claim 1 , and wherein the receiver element is positioned on the second arm.3. The digital slide scanning apparatus of claim 1 , wherein the at least a portion of the slide rack comprises a rear portion of the slide rack.4. The digital slide scanning apparatus of claim 3 , wherein the at least one processor is ...

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Номер записи: 81
25-02-2021 дата публикации

AUTOMATED SELECTION OF MICROORGANISMS AND IDENTIFICATION USING MALDI

Номер: US20210055318A1
Автор: Botma Jetze, Kleefstra Martijn, Van Der Zee Tino Walter
Принадлежит: BD Kiestra B.V.

A method and apparatus for locating and selecting a colony of microorganisms on a culture dish and identifying microorganisms in said selected colony using MALDI. The method comprises the automated steps of locating and selecting a colony of microorganisms on a culture dish; obtaining a sample of said selected colony of microorganisms; depositing at least some of said sample of said selected colony of microorganisms on a target plate; and transferring said target plate with said sample in an apparatus for performing MALDI for identification of said sample of said selected colony of microorganisms. A sample of a colony of microorganisms is automatically deposited on a depositing spot such that the sample covers at most approximately half of said one of the depositing spots of the target plate. A suspension of a sample of microorganisms is automatically prepared by automatically picking the sample with a picking tool and submerging the picking tool with said sample in a suspension, after which the picking tool is vibrated in vertical sense only to release the sample from the picking tool. 1. A method comprising:dispensing, with an automatic suspension medium dispenser, an initial amount of a suspension medium into a suspension tube held in a suspension tube holder;depositing, with a positioning device, a sample of a colony of microorganisms in the suspension tube by submerging a first picking tool in the suspension medium, wherein the first picking tool is positioned in a picking tool holder of the positioning device;oscillating, with the positioning device, the first picking tool in a linear vertical movement for a period of time;after the period of time during which the first picking tool is oscillated has elapsed, measuring, with a turbidity meter, the turbidity of the suspension medium contained in the suspension tube; anddepending on the measured turbidity, (a) dispensing, with the automatic suspension medium dispenser, an additional amount of the suspension ...

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Номер записи: 82
25-02-2021 дата публикации

DISPOSAL CONTAINER FOR TESTING APPARATUS AND TESTING APPARATUS

Номер: US20210055319A1
Автор: Koike Hiroki, NISHIKAWA Toru, TAMURA Nobuya
Принадлежит: SYSMEX CORPORATION

Disclosed is a testing apparatus comprising a disposal container body comprising: a first opening portion that faces upward to receive a used test piece dropped by a test piece transfer part of the testing apparatus, wherein the test piece transfer part is configured to transfer the used test piece to the first opening portion; and a second opening portion that faces laterally to receive a liquid waste and to which an end of a discharge pipe of the testing apparatus is inserted, wherein the discharge pipe is configured to transfer the liquid waste to the second opening portion. 120.-. (canceled)21. A method for collecting waste of a testing apparatus for testing a biological sample , comprising:providing the testing apparatus with a disposal container having a first opening at an upper portion and a second opening on a side wall;collecting, by the disposal container, a used test piece that is dropped from the testing apparatus through the first opening; andcollecting, by the disposal container, liquid waste from the testing apparatus through a discharge pipe inserted in the second opening.22. The method of claim 21 , whereinthe providing comprises inserting the discharge pipe in the second opening.23. The method of claim 21 , whereinthe providing comprises arranging the disposal container at a position where the used test piece drops into the disposal container through the first opening.24. The method of claim 23 , whereinthe testing apparatus comprises a conveyor belt to convey the used test piece toward an end of the conveyor belt, and the position is a lower position of the end of the conveyor belt.25. The method of claim 21 , further comprisingremoving the disposal container accommodating the used test piece and the liquid waste inside from the testing apparatus.26. The method of claim 25 , whereinthe disposal container comprises a cover portion attached to a main body of the disposal container, andthe method further comprising closing the first and second ...

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Номер записи: 83
25-02-2021 дата публикации

Test piece mounting body, transport unit, and test piece analyzer

Номер: US20210055320A1
Автор: Satoshi Hayashi, Takashi Kusuhara
Принадлежит: Sysmex Corp

A test piece analyzer capable of easily washing a transport device to which the sample (urine sample) has adhered is provided. A test piece analyzer is provided with a transport unit having a transport device to transport a test piece, a drive part to drive the transport device, an imaging unit to image the test piece, and a casing to house the transport unit, imaging unit, and drive part. The transport unit is removable relative to the casing.

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Номер записи: 84
13-02-2020 дата публикации

BIO/CHEMICAL ASSAY DEVICES AND METHODS FOR SIMPLIFIED STEPS, SMALL SAMPLES, ACCELERATED SPEED, AND EASE-OF-USE

Номер: US20200049600A1
Автор: CHOU Stephen Y., Ding Wei
Принадлежит: Essenlix Corporation

The present invention is related to the field of bio/chemical sampling, sensing, assays and applications. Particularly, the present invention is related to how to make the sampling/sensing/assay become simple to use, fast to results, highly sensitive, easy to use, using tiny sample volume (e.g. 0.5 uL or less), operated by a person without any professionals, reading by mobile-phone, or low cost, or a combination of them. 1296.-. (canceled)297. A method for locally releasing a reagent into a portion of a liquid sample , comprising:(a) obtaining a sample; (i) one or both of the plates comprise spacers that are fixed to a respective plate;', '(ii) one or both of the plates is flexible;', "(iii) the spacers have a pillar shape, a substantially flat top surface, a predetermined substantially uniform height and a predetermined constant inter-spacer distance that is at least about 2 times larger than the size of an analyte, and wherein the Young's modulus of the spacers times the filling factor of the spacers is equal or larger than 2 MPa; and", '(iv) the first plate comprises, on its surface, a storage site that has a predetermined area and comprises a reagent that, upon contacting the sample, dissolves into the sample and diffuses in the sample;, '(b) obtaining a first and second plates that are movable relative to each other into different configurations, wherein(c) depositing the sample on one or both of the plates when the plates are configured in an open configuration, wherein the open configuration is a configuration in which the two plates are either partially or completely separated apart and the spacing between the plates is not regulated by the spacers;(d) after (c), compressing the sample by bringing the two plates into a closed configuration, wherein the closed configuration is a configuration in which at least part of the sample is compressed into a layer of uniform thickness that is confined by the inner surfaces of the two plates and that covers the storage ...

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Номер записи: 85
13-02-2020 дата публикации

GAS KNIFE USING PARALLELOGRAM FLOW

Номер: US20200049601A1
Автор: Hassen Charles
Принадлежит:

In one aspect of the present disclosure is a method of contactlessly urging, directly, or moving a substance on the surface of a substrate, the method employing a gas knife () configured to produce a gas curtain having parallelogram flow. 1. An automated slide processing apparatus comprising:at least one fluid dispenser configured to dispense a fluid onto an upper surface of a slide; anda liquid removal device for driving the dispensed fluid on the upper surface of the slide toward at least one of (i) a wicking feature in communication with at least a portion of an end of the slide, or (ii) a longitudinal edge of the slide; where the liquid removal device projects a gas curtain having a shape which approximates a parallelogram.2. The automated slide processing apparatus of claim 1 , wherein the gas curtain projected from the liquid removal device is oriented substantially perpendicular to a plane of the upper surface of the slide.3. The automated slide processing apparatus of claim 1 , wherein the gas curtain projected from the liquid removal device is offset at a predetermined slant angle relative to a longitudinal axis of the liquid removal device.4. The automated slide processing apparatus of claim 1 , wherein the wicking feature is a slide retaining clip.5. The automated slide processing apparatus of claim 4 , wherein the slide retaining clip is located at a label end of the slide.6. The automated slide processing apparatus of claim 1 , wherein the automated slide processing apparatus is a coverslipper apparatus and wherein the liquid removal device facilitates removal of at least residual fluid after application of a coverslip.7. The automated slide processing apparatus of claim 1 , wherein the automated slide processing apparatus is a staining apparatus and wherein the liquid removal device facilitates removal of the fluid dispensed onto a specimen located on the upper surface of the slide claim 1 , the dispensed fluid selected from the group consisting of a ...

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Номер записи: 86
23-02-2017 дата публикации

ANTIGEN DETECTION USING PHOTOCLEAVABLE LABELS

Номер: US20170052175A1
Автор: CHEN Xiyi, FRYE Stacie, HEALY Mimi, PETRICHENKO Sophia, WANG Jinchun, Wu Weidong, Zhang Su
Принадлежит: LASERGEN, INC.

Provided herein are methods of using photocleavable labels for multiplex and serial antigen detection. The methods comprise detecting the presence of photocleavable labels, which are conjugated through functional linkers to antigen-binding complexes, which in turn non-covalently bind to antigens. The presence of a photocleavable label is indicative of the presence of an antigen specifically or selectively bound by an antigen-binding complex. Also provided are apparatuses for using photocleavable labels for multiplex and serial antigen detection. 2. The method of claim 1 , further comprising photocleaving the photocleavable label.3. The method of claim 2 , wherein photocleaving comprises exposing the sample to ultraviolet light.4. The method of claim 1 , wherein the photocleavable label comprises a reporter moiety covalently bound to a photocleavable moiety.5. The method of claim 4 , wherein the photocleavable moiety is selected from the group consisting of a 2-nitrobenzyl group claim 4 , a benzoin group claim 4 , a coumarinyl group claim 4 , and a p-hydroxyphenacyl group.6. The method of claim 5 , wherein the photocleavable moiety is a 2-nitrobenzyl group.7. The method of claim 6 , wherein the 2-nitrobenzyl group comprises a substitution on the α-carbon and/or on the benzene ring.8. The method of claim 1 , wherein the functional linker is a single-stranded oligonucleotide claim 1 , an at least partially double-stranded oligonucleotide claim 1 , a peptide claim 1 , or an alkanediyl.9. The method of claim 8 , wherein the partially double-stranded oligonucleotide is a fully double-stranded oligonucleotide.10. The method of claim 8 , wherein the at least partially double-stranded oligonucleotide is a hairpin oligonucleotide.12. The method of claim 11 , wherein the primary antibody is modified by at least one reducing agent.13. The method of claim 12 , wherein the at least one reducing agent is TCEP or 2-MEA.14. The method of claim 11 , wherein the conjugation moiety is ...

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Номер записи: 87
10-03-2022 дата публикации

Detection System

Номер: US20220072481A1
Автор: Kenji Ogata, Kenji Yamaoka
Принадлежит: I Pex Inc

Each of detection instruments (3a, 3b, 3c, 3d . . . ) of which the number is enabled to be increased or decreased includes at least one sensitive membrane sensitive to a substance, generates first data representing the result of detection of the substance corresponding to the sensitive membrane, and includes second data in which the result of the detection of the substance corresponding to the sensitive membrane is associated with the membrane information of the sensitive membrane. An information terminal (2) collects the first data and the second data from each of the detection instruments (3a, 3b, 3c, 3d . . . ), and compares the first data and the second data, to specify an object to be detected.

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Номер записи: 88
10-03-2022 дата публикации

Assay sample cards and adaptors and use of the same (ii)

Номер: US20220072557A1
Автор: Ji Qi, Stephen Y. Chou, WEI Ding
Принадлежит: Essenlix Corp

A device for sample analysis, including: a first plate, a second plate, spacers, a hinge, and an adhesive, wherein the first plate and the second plate are connected by the hinge and movable relative to each other around the axis of the hinge into different configurations, including an open configuration and a closed configuration as disclosed herein. Also disclosed are a kit, a system, and a method including the device.

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Номер записи: 89
21-02-2019 дата публикации

DEVICES, SYSTEMS AND METHODS FOR SAMPLE DETECTION

Номер: US20190054468A1
Автор: DuVall Jacquelyn A., Garner Gavin T., JACKSON Kimberly Renee, Landers James P., Li Jingyi, Mills Daniel
Принадлежит:

This disclosure provides for apparatuses, systems and methods for in vitro sample detection. For example in one embodiment, this disclosure provides an automated Pe-toner microfluidic device (and related method) on a centrifugal platform for DNA sample lysis and DNA extraction. A second embodiment provides a system and method for qualitative detection, quantification, and real-time monitoring of nucleic acid amplification products using magnetic bead aggregation inhibition. A third embodiment provides a platform for simultaneous detection of mRNA markers from blood, cell-free semen, sperm, saliva, and vaginal fluid. The third embodiment comprises a system and method that provide for simple, rapid, and fluorescence-free detection of body fluids using mRNA marker amplification and optical detection for mRNA marker analysis with a smart phone with image analysis. 1. A method to detect a target sequence in a sample , comprising:providing one or more aliquots of an amplification reaction specific for amplifying the target sequence in a sample;contacting the aliquot, magnetic beads and an amount of isolated nucleic acid of greater than about 5 kb in length, optionally under chaotropic conditions, thereby providing a mixture;subjecting the mixture to conditions that allow for aggregation of the beads, wherein the absence of aggregation under the conditions is indicative of the presence of amplified target sequence; anddetecting the presence or amount of aggregation.2. The method of wherein the target sequence is from a pathogen.3. The method of wherein the pathogen is a bacterium claim 2 , virus or parasite.4. The method of wherein the isolated nucleic acid is greater than about 10 kb in length.5. The method of wherein the conditions to allow aggregation are a rotating magnetic field claim 1 , acoustic energy or vibration.6. The method of wherein the aliquot is contacted with the beads before contact with the isolated nucleic acid.7. The method of wherein the aggregation ...

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Номер записи: 90
21-02-2019 дата публикации

FLUIDIC DEVICES WITH BEAD WELL GEOMETRIES WITH SPATIALLY SEPARATED BEAD RETENTION AND SIGNAL DETECTION SEGMENTS AND RELATED METHODS

Номер: US20190054470A1
Автор: Henley William Hampton, Ramsey John Michael
Принадлежит:

A fluidic device includes a plurality of reaction wells, typically in a dense array, with at least one bead retention segment in fluid communication with and spatially separated from at least one signal detection segment. A respective bead retention segment can be configured to hold a single bead, which can have a reagent attached thereto. 1. A fluidic device comprising:a plurality of reaction wells characterized in that the reaction wells have at least one bead retention segment and at least one spatially separated signal detection segment in fluid communication with the at least one bead retention segment.2. The device of claim 1 , wherein the device is a microfluidic chip and the reaction wells are provided as an array of reaction wells.3. The device of claim 1 , wherein the reaction wells have a volumetric capacity of between 1 aL to 1 μL.4. The device of claim 1 , wherein the at least one bead retention segment is sized and configured to hold only a respective single bead claim 1 , and wherein at least one of the at least one separate signal detection segment has an end portion that resides a distance L of between 0.3× to about 200× of a diameter of a target bead claim 1 , typically between 1 μm to 1 mm claim 1 , from one or more of the at least one bead retention segment claim 1 , optionally between 1 μm to 10 μm.5. The device of claim 1 , wherein the at least one bead retention segment is sized and configured to hold a microspherical bead with a diameter of between 100 nm to 1 mm claim 1 , and wherein the at least one bead retention segment has a width that is between 101% to 195% of the diameter of a respective bead held therein.6. The device of claim 1 , wherein the separate at least one signal detection segment comprises an elongate channel that has a width that is less than a width of an adjacent bead retention segment.7. The device of claim 1 , wherein the at least one bead retention segment is a single bead retention segment.8. The device of claim 1 , ...

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Номер записи: 91
21-02-2019 дата публикации

LOADING STATION

Номер: US20190056415A1
Автор: Cesar Christopher G., Facer Geoffrey R., Lai Janice H., Li Sixing, Spuhler Philipp S.
Принадлежит:

Disclosed herein are methods, devices, and systems for loading and retrieval of particles. In some embodiments, a loading station comprise a tray configured to receive a microwell array, a first magnet, a second magnet, and an actuation mechanism configured to cause movement of at least one of the first magnet and the second magnet. 1. A loading station comprising:a tray configured to receive a microwell array;a first magnet, the first magnet being movable between a first magnet active position in which the first magnet is positioned to exert a first magnetic force in a first direction on one or more magnetic particles positioned within the microwell array and a first magnet inactive position in which the first magnet is positioned to exert less magnetic force on the one or more magnetic particles positioned within the microwell array in comparison to the first magnet active position, wherein the first magnet is positioned inferior to the tray when the first magnet is in the first magnet active position;a second magnet, the second magnet being movable between a second magnet active position in which the second magnet is positioned to exert a second magnetic force in a second direction on the one or more magnetic particles positioned within the microwell array and a second magnet inactive position in which the second magnet is positioned to exert less magnetic force on the one or more magnetic particles positioned within the microwell array in comparison to the second magnet active position, wherein the second direction of the second magnetic force is different than the first direction of the first magnetic force; andan actuation mechanism configured to cause movement of at least one of the first magnet and the second magnet.2. The loading station of claim 1 , wherein the actuation mechanism comprises an actuator claim 1 , the actuator being movable between a plurality of different positions claim 1 , wherein at least some movements of the actuator cause movement of ...

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Номер записи: 92
21-02-2019 дата публикации

METHOD FOR PROTECTING AND UNPROTECTING THE FLUID PATH IN A CONTROLLED ENVIRONMENT ENCLOSURE

Номер: US20190056419A1
Автор: CICHY Marcin, PROCYSHYN Christopher
Принадлежит:

A controlled environment enclosure comprises a robotic arm manipulation system used to protect and unprotect a fluid path and a swab within the controlled environment enclosure. The apparatus allows the fluid path to be protected against dangerous decontamination vapors and chemicals before the controlled environment enclosure is decontaminated. The apparatus allows the fluid path to be unprotected without the use of gloves or other means that degrade the integrity of the controlled environment enclosure when decontamination is completed. The apparatus and method allow for the protecting, unprotecting and decontaminating sequences to be automated. In some embodiments the fluid path comprises a fill needle that can removably and aseptically be sealed with a disposable monolithic injection moulded polymeric fill needle sheath. The apparatus and method further allow for the use of a swab disposed in a swab holder that is aseptically and removably sealable to a swab cap to protect the swab against decontamination vapors. 1. A method for automatically carrying out a fluid handling process in controlled environment enclosure , comprising:providing a first implement inside a first sealed sheath, the first sheath being sealed by a detent-based sealing mechanism on the first sheath that keeps the first sheath aseptically sealed around the first implement,placing the first sheath in the controlled environment enclosure,decontaminating the controlled environment enclosure around the first sheath after the step of placing,actuating the sealing mechanism to open the first sheath, andcarrying out at least one step in the fluid handing process with the implement in the controlled environment enclosure.2. The method of wherein the step of providing includes providing a fill needle and wherein the step of carrying out includes carrying out a fill operation.3. The method of wherein the step of decontaminating takes place before the step of carrying out a fill operation claim 1 , ...

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Номер записи: 93
21-02-2019 дата публикации

Method for protecting and unprotecting the fluid path in a controlled environment enclosure

Номер: US20190056420A1
Автор: Christopher Procyshyn, Marcin Cichy
Принадлежит: VanRx Pharmasystems Inc

A controlled environment enclosure comprises a robotic arm manipulation system used to protect and unprotect a fluid path and a swab within the controlled environment enclosure. The apparatus allows the fluid path to be protected against dangerous decontamination vapors and chemicals before the controlled environment enclosure is decontaminated. The apparatus allows the fluid path to be unprotected without the use of gloves or other means that degrade the integrity of the controlled environment enclosure when decontamination is completed. The apparatus and method allow for the protecting, unprotecting and decontaminating sequences to be automated. In some embodiments the fluid path comprises a fill needle that can removably and aseptically be sealed with a disposable monolithic injection moulded polymeric fill needle sheath. The apparatus and method further allow for the use of a swab disposed in a swab holder that is aseptically and removably sealable to a swab cap to protect the swab against decontamination vapors.

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Номер записи: 94
01-03-2018 дата публикации

SMEAR PREPARING APPARATUS AND SMEAR PREPARING METHOD

Номер: US20180058989A1
Автор: KONDO Saki, NAKAJIMA Takayuki, Nakanishi Noriyuki, Oda Tetsuya, SHINABE Seiya, Yamasaki Mitsuo
Принадлежит: SYSMEX CORPORATION

A smear preparing apparatus includes: a smear unit that prepares a smear slide by smearing a sample on a slide; a buffer solution preparation unit that prepares diluted buffer solution by diluting a highly-concentrated buffer solution; a diluted staining solution preparation unit that prepares diluted staining solution by diluting a highly-concentrated staining solution with the diluted buffer solution; and a stain unit that stains the smear slide prepared by the smear unit with the diluted staining solution. 1. A smear preparing apparatus comprising:a smear unit that prepares a smear slide by smearing a sample on a slide;a buffer solution preparation unit that prepares diluted buffer solution by diluting a highly-concentrated buffer solution;a diluted staining solution preparation unit that prepares diluted staining solution by diluting a highly-concentrated staining solution with the diluted buffer solution; anda stain unit that stains the smear slide prepared by the smear unit with the diluted staining solution.2. The smear preparing apparatus according to claim 1 , further comprising:a diluted solution storage unit that stores diluted solution and;a buffer solution storage unit that stores the highly-concentrated buffer solution, whereinthe buffer solution preparation unit prepares the diluted buffer solution by diluting the highly-concentrated buffer solution stored in the buffer solution storage unit with the diluted solution stored in the diluted solution storage unit.3. The smear preparing apparatus according to claim 2 , further comprisinga cleaning unit that cleans the smear slide stained by the stain unit with the diluted solution stored in the diluted solution storage unit.4. The smear preparing apparatus according to claim 1 , whereinthe diluted staining solution preparation unit comprises a first diluted staining solution preparation chamber and a second diluted staining solution preparation chamber that prepare different kinds of diluted staining ...

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Номер записи: 95
01-03-2018 дата публикации

APPARATUS AND METHOD FOR PICKING BIOLOGICAL SAMPLE

Номер: US20180059132A1
Автор: Christey Peter, Hallock Alexander
Принадлежит:

A picking instrument for picking biological samples, such as microbial samples, includes a picking pin having a distal tip and three degrees-of-freedom and configured to move in x, y, and z directions. The picking instrument also includes a loading platform comprising a first area and a second area, the first area configured to accommodate and secure a microfabricated chip including a plurality of microwells. The picking pin is programmatically controlled to pick a sample contained in one or more selected microwells of the microfabricated chip and then transfer the sample to a predetermined location at the destination sample holder. Methods of operating the picking instrument, including calibrating the coordinates of the selected microwell(s) relative to a location of the picking pin, are also provided. 1. A method of transferring a sample from at least one selected microwell of a microfabricated chip including a plurality of microwells to a predetermined location in a destination sample holder using a picking instrument comprising a picking pin having a distal tip , the picking pin having three degrees-of-freedom and configured to move in x , y , and z directions , the x , y directions constituting an x-y plane , the method comprising:calibrating the position of the microfabricated chip relative to the position of the picking pin;determining the coordinates of the at least one selected microwell of the microfabricated chip for picking on the x-y plane relative to the position of the picking pin based on the calibration;based on a current position of picking pin and the determined coordinates of the at least one selected microwell, moving the picking pin to a position above the location of the at least one selected microwell;dipping at least a portion of the distal tip of the picking pin into the at least one selected microwell to pick up a sample contained in the at least one selected microwell; andmoving the picking pin and transferring the sample to a ...

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Номер записи: 96
02-03-2017 дата публикации

SAMPLE PREPARATION DEVICE AND ASSOCIATED METHOD

Номер: US20170059457A1
Автор: Fox William Alan, Langhoff Brian Reuben, Williams Ryan Carl
Принадлежит: BECTON, DICKINSON AND COMPANY

A sample preparation device and associated method is provided for preparing samples according to an assay protocol. A cell deposition module deposits a sample on each a plurality of assay devices supported by a support device. An epitope retrieval module deposits a reagent on each of the samples. Each of the samples is brought to a selected temperature. A heating device, corresponding to each of the assay devices, directly interacts with the corresponding assay device may be used to heat each assay device to the selected temperature, in conjunction with the epitope retrieval module depositing the reagent on each of the samples. A staining module deposits a staining reagent on each of the samples, and removes excess staining reagent. The staining, epitope retrieval, and cell deposition modules cooperate with the support device and heating devices to form a unitary sample preparation device. 112-. (canceled)13. A method of preparing a sample according to an assay protocol , using a unitary sample preparation device , said method comprising:supporting a plurality of assay devices with a support device;depositing a sample on each of the plurality of assay devices supported by the support device in a cell deposition module operably engaged therewith;depositing at least one reagent on each of the samples, according to the assay protocol, in an epitope retrieval module operably engaged with the cell deposition module and the support device;depositing a staining reagent on each of the samples, according to the assay protocol, and removing excess staining reagent therefrom upon staining of the samples, in a staining module operably engaged with the epitope retrieval module, the cell deposition module, and the support device, the staining module, the epitope retrieval module, and the cell deposition module cooperating with the support device for preparing the sample without movement of the assay devices via the support device; andbringing each of the samples to a selected ...

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Номер записи: 97
05-03-2015 дата публикации

INTEGRATED SENSORS

Номер: US20150065390A1
Автор: Bratkovski Alexandre M., Hu Min, Kim Ansoon, Li Zhiyong, Williams R. Stanley, Wu Wei
Принадлежит:

Examples of integrated sensors are disclosed herein. An example of an integrated sensor includes a substrate and a sensing member formed on a surface of the substrate. The sensing member includes collapsible signal amplifying structures and an area surrounding the collapsible signal amplifying structures that enables self-positioning of droplets exposed thereto toward the collapsible signal amplifying structures. 1. An integrated sensor , comprising:a substrate; and collapsible signal amplifying structures; and', 'an area surrounding the collapsible signal amplifying structures that enables self-positioning of droplets exposed thereto toward the collapsible signal amplifying structures., 'a sensing member formed on a surface of the substrate, the sensing member including2. The integrated sensor as defined in wherein the area surrounding the collapsible signal amplifying structures is more hydrophobic than the collapsible signal amplifying structures.3. The integrated sensor as defined in wherein the area surrounding the collapsible signal amplifying structures includes a gradient of polymer pillars formed on the substrate claim 2 , the gradient of polymer pillars being more dense at a periphery of the sensing member.4. The integrated sensor as defined in wherein:the collapsible signal amplifying structures include metal-capped polymer-pillars, metal-coated polymer nanoflakes, metal-coated mushroom-shaped structures, or metal-ringed polymer pillars; andthe polymer pillars in the gradient are free of signal amplifying material.5. The integrated sensor as defined in wherein the area surrounding the collapsible signal amplifying structures includes hydrophobic molecules deposited thereon.6. The integrated sensor as defined in wherein the area surrounding the collapsible signal amplifying structures includes grooves defined in the surface of the substrate claim 1 , the grooves having a shape that directs the droplets toward the collapsible signal amplifying structures.7. ...

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Номер записи: 98
27-02-2020 дата публикации

FLUIDIC CENTRIPETAL DEVICE

Номер: US20200061607A1
Автор: Chapdelaine Sébastien, Peytavi Régis
Принадлежит:

A fluidic centripetal apparatus for testing components of a biological material in a fluid is presented. The fluidic centripetal device is adapted to be received within a rotatable holder. The apparatus comprises a fluidic component layer having fluidic features on at least a front face and a bottom component layer bonded to a rear of the fluidic component layer thereby creating a fluidic network through which the fluid flows under centripetal force. In one embodiment, the fluidic feature may be a bottom-Tillable chamber coupled to an entry channel for receiving the fluid, the chamber inlet being provided at an outer side of the bottom-fillable chamber. In another embodiment, the fluidic feature may be a retention chamber coupled to an entry channel for receiving the fluid, a container wholly provided in the retention chamber and containing a liquid diluent, the container maintaining the liquid diluent in the container until it releases it in the retention chamber upon application of an external force to the container, thereby restoring the fluidic connection between the liquid diluent and the fluid in the retention chamber. Additionally, the retention chamber can have a flow decoupling receptacle for receiving the fluid, located at the outer side of the retention chamber and interrupting a fluidic connection between the entry and exit of the retention chamber. A test apparatus and a testing method using a fluidic centripetal device for testing components of a biological material in a fluid are also provided. 111-. (canceled)12. A fluidic centripetal apparatus for testing components of a biological material in a fluid , said fluidic centripetal device having a shape adapted to be received within a rotatable holder , said rotatable holder having a center of rotation and an outer edge , said fluidic centripetal device extending radially between said center of rotation and said outer edge , an inner side of said fluidic centripetal device being located towards said ...

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Номер записи: 99
17-03-2022 дата публикации

SMEAR PREPARATION MACHINE AND SAMPLE STAINING METHOD

Номер: US20220082480A1
Автор: LAI Fuxing, Liu Yingming, TENG Jin
Принадлежит:

A smear preparation machine includes: a slide loading mechanism () configured to load a slide; a sample applying mechanism () configured to apply a blood sample to the slide; a smearing mechanism () configured to smear the blood sample on the slide to prepare a smear; a dripping and staining mechanism () configured to drip a staining reagent and a buffer solution to the smear; an air blowing mechanism configured to blow air to the staining reagent and the buffer solution on the smear for blowing mixing, such that the staining reagent and the buffer solution are mixed and cover the smear, thereby staining the smear once. 1. A smear preparation machine , comprising:a slide loading mechanism configured to load a slide,a sample applying mechanism configured to apply a blood sample onto the slide,a smearing mechanism configured to smear the blood sample on the slide to prepare a smear,a dripping and staining mechanism configured to drip a staining reagent and a buffer solution to the smear, andan air blowing mechanism configured to blow air to the staining reagent and the buffer solution on the smear for blowing mixing, such that the staining reagent and the buffer solution are mixed and cover the smear to perform staining on the smear.2. The smear preparation machine of claim 1 , wherein the air blowing mechanism comprises an air source claim 1 , a blowing mixing component and an air blowing control valve claim 1 , wherein the air blowing control valve is connected to the air source and the blowing mixing component respectively; whereinthe air source is configured to provide an airflow; andthe blowing mixing component is configured to blow the airflow provided by the air source to the staining reagent and the buffer solution to perform the blowing mixing when the air blowing control valve is opened.3. The smear preparation machine of claim 2 , wherein the blowing mixing component comprises at least one air inlet claim 2 , at least one airflow pipeline claim 2 , and a ...

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Номер записи: 100