21-11-2013 дата публикации
Номер: US20130311202A1
The invention provides a computer program product for selecting and administering a psychotropic medication for a patient. The computer program product utilizes a combination of genotype and phenotype information to provide the user with accurate guidance regarding the appropriate medication and its use. 147-. (canceled)48. A computer program product containing executable instructions that when executed cause a processor to perform operations comprising: (a) a cytochrome P450 CYP2D6 gene consisting of two alleles independently selected from the group consisting of fully functional alleles 2D6*1A, *2, *2N, and *35, partially functional alleles 2D6*10 and *17, and non-functional alleles 2D6*3, *4, *5, *6, *7, *8, and *12,', '(b) a cytochrome P450 CYP2C19 gene consisting of two alleles independently selected from the group consisting of fully functional alleles 2C19*1A and *1B, and non-functional alleles 2C19*2A, *2B, *3, *4, *5A, *5B, *6, *7 and *8, and', '(c) a serotonin transporter gene 5HTTR consisting of two alleles independently selected from the short (s) and long (l) forms of the 5HTTR gene;, '(1) receiving a plurality of genotypes for a panel of genes, wherein said panel of genes comprises the following(2) receiving a plurality of metabolic phenotypes based on the genotypes of the cytochrome P450 genes in (1), wherein the metabolic phenotype is selected from poor (P), intermediate (I), and extensive (E), andsaid phenotypes are assigned based upon the number of functional alleles for each cytochrome P450 gene as follows: P=no fully functional alleles and either one or no partially functional alleles, I=either one fully functional allele and a non-functional allele or two partially functional alleles, and E=either one fully functional allele and one partially functional allele or two fully functional alleles;(3) receiving a plurality of medication profiles, wherein said profiles are specified based on the genotypes and phenotypes in (1) and (2) and wherein said ...
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