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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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Поддерживает ввод нескольких поисковых фраз (по одной на строку). При поиске обеспечивает поддержку морфологии русского и английского языка
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Применить Всего найдено 1641. Отображено 100.
31-10-2013 дата публикации

CHROMATOGRAPH MASS SPECTROMETER

Номер: US20130284919A1
Автор: Mukaibatake Kazuo
Принадлежит:

When an SIM measurement for ions originating from a target component separated by a chromatograph is performed, the measurement is performed while the mass-resolving power is switched among a plurality of levels of resolving power, with the mass-to-charge ratio fixed at a target value (S), and an extracted ion chromatogram is created based on each of data obtained corresponding to respective mass-resolving powers (S). After the extracted ion chromatograms are obtained, an S/N ratio is calculated for a peak of the target component on each of the chromatograms (S), and a mass-resolving power which yields the highest S/N ratio is selected (S). The selected mass-resolving power is set as the mass-resolving power in the subsequent measurements of the same target component in the same kind of sample (S), and the quantitative determination of the target component is performed using the extracted ion chromatogram obtained with the selected mass-resolving power (S). 1. A chromatograph mass spectrometer having a chromatograph in which components of a sample are separated in a temporal direction and a mass spectrometer with a quadrupole mass filter in which ions originating from the components of the sample separated by the chromatograph are separated according to mass-to-charge ratios thereof , the chromatograph mass spectrometer comprising:a) a quadrupole driver for applying a direct-current voltage and a radio-frequency voltage to each electrode constituting the quadrupole mass filter, so as to selectively allow an ion having a specific mass-to-charge ratio to pass through;b) a controller for controlling the quadrupole driver so as to change the applied voltages in such a manner that a mass-resolving power is sequentially switched among a plurality of previously determined levels of mass-resolving power when a target ion originating from a target component is allowed to pass through the quadrupole mass filter and be detected; andc) a chromatogram creator for creating an ...

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Номер записи: 1
28-11-2013 дата публикации

QUADRUPOLE MASS SPECTROMETER

Номер: US20130313427A1
Автор: Mizutani Shiro
Принадлежит:

A quadrupole power source which applies a voltage to each electrode (-) of a quadrupole mass filter () receives inputs of an m/z-axis correction coefficient Mcomp and a V-voltage correction coefficient Vcomp in addition to a power supply controlling voltage Qcont according to the m/z of a target ion. Vcomp is a reciprocal of the ratio by which a frequency is changed, while Mcomp is the square of the ratio by which the frequency is changed. In a detection gain adjuster section (C), a multiplier () multiplies an output Vdet′ of a V-voltage adjusting amplifier () by Vcomp whereby the radio-frequency voltage produced by a radio-frequency power supply section (A) is maintained at the same level even when the set frequency of a signal generator () is changed in order to tune an LC resonance circuit. 1. A quadrupole mass spectrometer including a quadrupole mass filter composed of a plurality of electrodes , a quadrupole power source for applying a predetermined voltage to each of the electrodes of the quadrupole mass filter so as to selectively allow an ion having a specific mass-to-charge ratio to pass through the quadrupole mass filter , and a controller for giving the quadrupole power source an instruction on a target voltage corresponding to the mass-to-charge ratio of a target ion ,the quadrupole power source having a wave detector for detecting a radio-frequency voltage applied to the quadrupole mass filter and generating a DC detection output, a detection output adjuster for adjusting a gain of the detection output generated by the wave detector, a radio-frequency power source which includes a signal generator for generating a radio-frequency signal with a variable frequency and which produces a radio-frequency voltage whose amplitude is based on a comparison between an output of the detection output adjuster and the target voltage and whose frequency is equal to or proportional to the frequency of the radio-frequency signal, a direct-current power source for ...

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Номер записи: 2
19-12-2013 дата публикации

TRIPLE QUADRUPOLE MASS SPECTROMETER

Номер: US20130334415A1
Автор: Okumura Daisuke, Sugawara Hiroshi
Принадлежит: SHIMADZU CORPORATION

A high-quality mass spectrum is provided with alleviated mass/charge axis deviation in a triple quadrupole mass spectrometer even when executing a high-speed mass scan with MS/MS analysis. Mass calibration tables which denote relations between m/z and a mass deviation value which scan speed is a parameter are prepared separately for use in MS analyses without involving dissociation operations and MS/MS analyses with involving dissociation operations. According to a measuring mode, such as a product ion scan measurement or a neutral loss scan measurement, when performing MS/MS analysis, a mass deviation value for the minimum scan speed in a table is used for a quadrupole where the selected m/z is fixed, and a mass deviation value for a designated scan speed in a table is used for a quadrupole where the mass scan is performed, thus controlling the operations of each of a pre-stage and a post-stage quadrupoles. 1. A triple quadrupole mass spectrometer , comprising:an ion source, ionizing a sample;a pre-stage quadrupole, for selecting, from various ions generated by the ion source, first ions having a first specific mass-to-charge ratio as precursor ions;a collision cell, performing a dissociation operation to dissociate the precursor ions;a post-stage quadrupole, for selecting second ions having a second specific mass-to-charge ratio from various product ions generated by the dissociation operation;a detector, detecting the second ions passing through the post-stage quadrupole;a calibration information memory unit to store in advance mass calibration information showing a relationship between a mass-to-charge ratio and calibration values in each measuring mode, in which a scan speed is used as a parameter, of a MS analysis not involving the dissociation operation in the collision cell and of a MS/MS analysis involving the dissociation operation; anda control unit, reading, from the calibration information memory unit, mass calibration information corresponding to an ...

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Номер записи: 3
13-01-2022 дата публикации

ANALYSIS METHOD AND NON-TRANSITORY COMPUTER READABLE MEDIUM

Номер: US20220013344A1
Автор: KUDO Yukihiko, Sugimoto Shinji
Принадлежит: SHIMADZU CORPORATION

An analysis method includes analyzing a reference sample that contains a predetermined amount of a predetermined component by an analysis device using a chromatograph and obtaining a reference detection value which is a detection value of the predetermined amount of the predetermined component detected by the analysis device, calculating a judgment reference value which is a criterion for judging whether a concentration of a detection subject component in a measurement subject sample is equal to or larger than a reference concentration or equal to or smaller than the reference concentration based on the reference detection value, and analyzing the measurement subject sample by the analysis device and judging that the detection subject component has been detected in a case where a detection value exceeding the judgment reference value is detected in a peak detection time zone corresponding to the detection subject component. 1. An analysis method including:analyzing a reference sample that contains a predetermined amount of a predetermined component by an analysis device using a chromatograph and obtaining a reference detection value which is a detection value of the predetermined amount of the predetermined component detected by the analysis device;calculating a judgment reference value which is a criterion for judging whether a concentration of a detection subject component in a measurement subject sample is equal to or larger than a reference concentration or equal to or smaller than the reference concentration based on the reference detection value; andanalyzing the measurement subject sample by the analysis device and judging that the detection subject component has been detected in a case where a detection value exceeding the judgment reference value is detected in a peak detection time zone corresponding to the detection subject component.2. The analysis method according to claim 1 , whereindetection of the detection subject component or non-detection of the ...

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Номер записи: 4
02-01-2020 дата публикации

Ion guide

Номер: US20200006045A1
Автор: Alexander A. Makarov, Alexander Wagner, HAMISH Stewart
Принадлежит: Thermo Fisher Scientific Bremen GmbH

An ion guide may comprise a set of plate electrodes, each plate electrode having a plurality of apertures formed therethrough. The set of plate electrodes are spatially arranged such that a relative positioning of each plurality of apertures of a respective plate electrode of the set of plate electrodes and respective adjacent plate electrodes of the set of plate electrodes defines a continuous ion flight path through the respective plurality of apertures of each plate electrode of the set of plate electrodes. The continuous ion flight path has a helical-based and/or spiral-based shape.

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Номер записи: 5
03-01-2019 дата публикации

Mass Spectrometer

Номер: US20190006164A1
Автор: Terui Yasushi, YOSHINARI Kiyomi
Принадлежит:

Acceleration of decelerated ions and a reduction in the velocity dispersion width of decelerated ions are both achieved, whereby the sensitivity of detected ion sensitivity is improved and resolution is improved. The distance dx between at least one set of facing rod-shaped electrodes among rod-shaped electrodes (--) to (--) differs at the inlet part at which ions enter and the outlet part at which ions exit, and the distance dx between the at least one set of facing rod-shaped electrodes is gradually reduced or increased from the inlet part toward the outlet part. 1. A mass spectrometer , comprising:2n rod-like electrodes; and{'sub': 'RF', 'a control unit configured to apply a DC voltage U and a radio frequency voltage Vcos Ωt to the rod-like electrodes to generate a high-frequency multipole electric field equal to or more than a quadrupole electric field between the rod-like electrodes, whereina distance between at least a pair of facing rod-like electrodes of the rod-like electrodes at an entrance portion that ions enter is different from the distance at an exit portion from which ions are emitted; andthe distance between the at least pair of the facing rod-like electrodes is gradually reduced from the entrance portion toward the exit portion.2. A mass spectrometer , comprising:2n rod-like electrodes; and{'sub': 'RF', 'a control unit configured to apply a DC voltage U and a radio frequency voltage Vcos Ωt to the rod-like electrodes to generate a high-frequency multipole electric field equal to or more than a quadrupole electric field between the rod-like electrodes, whereina distance between at least a pair of facing rod-like electrodes of the rod-like electrodes at an entrance portion that ions enter is different from the distance at an exit portion from which ions are emitted; andthe distance between the at least pair of the facing rod-like electrodes is gradually increased from the entrance portion toward the exit portion.3. The mass spectrometer according to ...

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Номер записи: 6
15-01-2015 дата публикации

SYSTEMS AND METHODS FOR TRANSFER OF IONS FOR ANALYSIS

Номер: US20150014525A1
Автор: Charipar Nicholas Alan, Cooks Robert Graham, Garimella Sandilya Venkata, Harper Jason David, Ouyang Zheng
Принадлежит:

The invention generally relates to systems and methods for transferring ions for analysis. In certain embodiments, the invention provides a system for analyzing a sample including an ionizing source for converting molecules of a sample into gas phase ions in a region at about atmospheric pressure, an ion analysis device, and an ion transfer member operably coupled to a gas flow generating device, in which the gas flow generating device produces a laminar gas flow that transfers the gas phase ions through the ion transfer member to an inlet of the ion analysis device. 128-. (canceled)29. A system for analyzing a sample , the system comprising:an ionizing source for converting molecules of a sample into sample ions, the ionizing source comprising a gas inlet port and an electrode positioned within the source to interact with a gas introduced through the gas inlet port and to generate a discharge that interacts with the sample to produce the sample ions;an ion analysis device; andan ion transfer member operably coupled to a gas flow generating device, wherein the gas flow generating device produces a laminar gas flow without regions of recirculation that transfers the sample ions through the ion transfer member to an inlet of the ion analysis device.30. The system according to claim 29 , further comprising a gas source operably coupled to the gas inlet port.31. The system according to claim 30 , wherein the gas is helium.32. The system according to claim 29 , wherein the gas flow generating device is a pump.33. The system according to claim 29 , wherein the gas flow generating device is a gas jet of the ionizing source.34. The system according to claim 29 , wherein the ion transfer member is a tube.35. The system according to claim 34 , wherein the tube is composed of a rigid material.36. The system according to claim 35 , wherein the rigid material is metal or glass.37. The system according to claim 34 , wherein the tube is composed of a flexible material.38. The ...

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Номер записи: 7
09-01-2020 дата публикации

TANDEM MASS SPECTROMETER AND PROGRAM FOR THE SAME

Номер: US20200013599A1
Автор: Toyama Atsuhiko, Yamamoto Hideki
Принадлежит: SHIMADZU CORPORATION

As soon as a set of data is acquired by a mass spectrometric analysis, an accumulated value of the signal intensity on the mass spectrum is calculated for each m/z segment obtained by dividing the entire m/z range covered by the measurement by a predetermined m/z width. Only the m/z segments with accumulated signal-intensity values equal to or greater than a predetermined threshold are selected as the target for an MS/MS analysis. MS/MS analysis is performed for each selected m/z segment, using ions whose m/z values fall within the m/z segment as precursor ions. A measurement cycle which includes mass spectrometric analysis performed one time and MS/MS analysis performed one or more times is repeated. After that, ions originating from the same component are selected based on the retention time of a peak in an extracted ion chromatogram created for each product ion, and the component is identified. 1. A tandem mass spectrometer including a first mass-separating section configured to select , as a precursor ion , an ion having a specific mass-to-charge ratio or ions having a specific mass-to-charge-ratio range among ions originating from a sample , an ion-dissociating section configured to dissociate the precursor ion , and a second mass-separating section configured to perform a mass spectrometric analysis for various product ions generated by dissociation of the precursor ion , the tandem mass spectrometer comprising:a) a mass spectrometry controller configured to control each of the aforementioned sections so as to acquire mass spectrum data by performing a mass spectrometric analysis in the second mass-separating section, without performing selection of an ion in the first mass-separating section and dissociation of an ion in the ion-dissociating section;b) a mass-to-charge-ratio segment determiner configured to select one or more mass-to-charge-ratio segments from a plurality of mass-to-charge-ratio segments obtained by dividing an entire mass-to-charge-ratio ...

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Номер записи: 8
09-01-2020 дата публикации

Physical Isolation of Adducts and Other Complicating Factors in Precursor Ion Selection for IDA

Номер: US20200013609A1
Автор: Tate Stephen Alexander
Принадлежит:

A system is disclosed for identifying precursor ions originating from an ion source device. A mass filter filters an ion beam by using a series of overlapping precursor ion mass selection windows across the precursor ion mass range. A mass analyzer analyzes the precursor ions of each precursor ion mass selection window of the series, producing a plurality of precursor ion spectra for the precursor ion mass range. A precursor ion is selected from the spectra. The intensities for the selected precursor ion are retrieved from the spectra and a trace is produced that describes how the intensity of the selected precursor ion varies with the location of the precursor ion mass selection window. The selected precursor ion is identified as a precursor ion originating from the ion source device if the trace includes a nonzero intensity for the m/z value of the selected precursor ion. 1. A system for identifying precursor ions originating from an ion source device using a scanning sequential windowed precursor ion selection and mass analysis survey scan , comprising:an ion source device that ionizes and transforms a sample into an ion beam;a mass filter receives the ion beam;a mass analyzer; anda processor in communication with the mass filter and the mass analyzer that(a) instructs the mass filter to filter the ion beam by scanning a precursor ion mass selection window with a width smaller than a precursor ion mass range of interest across a precursor ion mass range of interest in overlapping steps, producing a series of overlapping precursor ion mass selection windows across the precursor ion mass range, and instructs the mass filter to transmit precursor ions from each precursor ion mass selection window of the series of overlapping precursor ion mass selection windows to the mass analyzer,(b) instructs the mass analyzer to analyze the precursor ions of each precursor ion mass selection window of the series of overlapping precursor ion mass selection windows, producing a ...

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Номер записи: 9
03-02-2022 дата публикации

Method and apparatus for data independent combined ion mobility and mass spectroscopy analysis

Номер: US20220034840A1
Автор: TENZER Stefan
Принадлежит:

An apparatus and a method of data independent combined ion mobility and mass spectroscopy analysis includes introducing precursor ions into an ion mobility spectrometer (IMS), sequentially releasing precursor ions from said IMS according to their ion mobility, introducing said released precursor ions into a mass filter, fragmenting the precursor ions transmitted through said mass filter to generate fragment ions, and carrying out a mass spectroscopy measurement on said fragment ions. The IMS and mass filter are controlled in a synchronized manner to carry out a plurality of IM scans, wherein adjacent mass windows in said IM scan that are associated with consecutive mass spectroscopy measurements of fragment ions overlap, such that precursor ions transmitted through said mass filter during said IM scan are located in at least one continuous scan region in an m/z-IM plane which extends in a generally diagonal direction in said m/z-IM plane. 1. A method of data independent combined ion mobility and mass spectroscopy analysis , comprising the following steps:introducing precursor ions into an ion mobility separator (IMS), sequentially releasing precursor ions from said IMS according to their ion mobility,introducing said released precursor ions into a mass filter which selectively transmits precursor ions having m/z values falling within a controllable mass window,fragmenting the precursor ions transmitted through said mass filter to generate fragment ions,carrying out a mass spectroscopy measurement on said fragment ions, wherein each fragment ion is associated with a mass window and an ion mobility (IM) range, and associating detected fragments with its corresponding precursor ion,wherein said IMS and said mass filter are controlled in a synchronized manner such as to carry out a plurality of IM scans, during which precursor ions of increasing or decreasing IM are successively released from said IMS, and during which the mass window of said mass filter is shifted ...

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Номер записи: 10
17-01-2019 дата публикации

METHOD FOR QUANTIFYING COGNITIVE DYSFUNCTION DISEASE BIOMAKER USING MASS SPECTROMETRY AND MASS SPECTROMETER

Номер: US20190018021A1
Автор: KAWAKAMI Daisuke, Matsubara Toshiya
Принадлежит: SHIMADZU CORPORATION

In the present invention, multiple reaction monitoring (MRM) measurements of at least one peptide selected from the group consisting of 14 peptides as biomarkers of cognitive dysfunction diseases contained in a biological sample are performed using a mass spectrometer capable of MS/MS measurement, and the peptide is quantified based on a result thereof. In this case, for each peptide, an MRM transition which is a combination of a mass-to-charge ratio of a precursor ion and a mass-to-charge ratio of a product ion is stored in advance in a storage unit of the mass spectrometer as a measurement condition of the MRM measurement, and the MRM transition is used when cognitive dysfunction disease biomarkers are detected. 1. A method for quantifying a cognitive dysfunction disease biomarker based on a result obtained by performing a multiple reaction monitoring (MRM) measurement using a mass spectrometer capable of MS/MS measurement of the cognitive dysfunction disease biomarker contained in a biological sample ,whereinthe cognitive dysfunction disease biomarker includes at least one peptide selected from the group consisting of:a complement C4-A-derived peptide AD1008 composed of an amino acid sequence represented by SEQ ID NO: 1,a transcription factor AP-2γ-derived peptide AD1025 composed of an amino acid sequence represented by SEQ ID NO: 2,an oxytocin receptor-derived peptide AD1042 composed of an amino acid sequence represented by SEQ ID NO: 3,an E3 ubiquitin ligase HERC-derived peptide AD1046 composed of an amino acid sequence represented by SEQ ID NO: 4,a prothrombin-derived peptide AD1048 composed of an amino acid sequence represented by SEQ ID NO: 5,a complement C4-derived peptide AD1049 composed of an amino acid sequence represented by SEQ ID NO: 6,a tumor necrosis factor receptor superfamily member 16-derived peptide ADPEP109315 composed of an amino acid sequence represented by SEQ ID NO: 7,a gelsolin-derived peptide ADPEP421488 composed of an amino acid sequence ...

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Номер записи: 11
10-02-2022 дата публикации

GAS ANALYZER APPARATUS AND METHOD FOR CONTROLLING GAS ANALYZER APPARATUS

Номер: US20220042948A1
Автор: Murthy Prakash Sreedhar, TAKAHASHI Naoki
Принадлежит:

There is provided a gas analyzer apparatus that analyzes inflowing sample gas. The gas analyzer apparatus includes a filter unit that filters the sample gas, a detector unit that detects the result of filtering, a housing that houses these elements, and a control unit that controls the respective potentials of these elements. The control unit includes a cleaning control unit that sets the respective potentials of the filter unit, the detector unit, and the housing to cleaning potentials that draws in, as plasma for cleaning purposes, process plasma from a source that supplies the sample gas or plasma generated by a plasma generation unit. 1. A gas analyzer apparatus that analyzes inflowing sample gas and comprises:a filter unit that filters the sample gas;a detector unit that detects filtered results;a housing that houses the filter unit and the detector unit; anda control unit that controls respective potentials of the filter unit, the detector unit, and the housing,wherein the control unit includes a cleaning control unit that sets the respective potentials of the filter unit, the detector unit, and the housing to cleaning potentials for drawing in, instead of potentials for analyzing that lead ions to the detector unit, as plasma for cleaning purposes, one of process plasma of a source that supplies the sample gas and plasma generated by a plasma generation unit, andthe cleaning potentials include potentials for forming a voltage gradient that aims toward the housing for drawing in the plasma by setting as the respective potentials of the filter unit, the detector unit and the housing.2. The gas analyzer apparatus according to claim 1 ,wherein the cleaning control unit sets a cleaning potential of the housing to a negative potentials.3. The gas analyzer apparatus according to claim 1 ,further comprising the plasma generation unit.4. The gas analyzer apparatus according to claim 1 ,wherein the cleaning control unit includes a unit that sets the cleaning potentials ...

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Номер записи: 12
28-01-2016 дата публикации

Collision Cell Multipole

Номер: US20160027633A1
Автор: Jung Gerhard, ROTTMANN Lothar
Принадлежит:

Mass spectrometer collision/reaction cell multipole and method. The multipole may have first and second portions and an intermediate portion therebetween, the first and second portions operating at first and second q values lower than a third q value at the intermediate portion. A low-mass cut-off of the multipole may be controlled by varying a q value from a first to at least a second value. The multipole may have multipole electrodes disposed about a central axis and having a respective first portion, second portion, and intermediate portion therebetween which is radially closer to the central axis. This offers relatively high acceptance and ion transmission, while providing low-mass cut-off for removing undesired/interfering ions and helping reduce background count. 1. A collision cell multipole , the multipole comprising a plurality of multipole electrodes disposed about a central axis , at least some of the multipole electrodes having a respective first portion , second portion , and intermediate portion therebetween , wherein the intermediate portion is radially closer to the central axis than its respective first portion and second portion.2. The collision cell multipole of claim 1 , wherein the at least some of the multipole electrodes comprise one or more respective pairs of radially opposing electrodes in the multipole.3. The collision cell multipole of claim 1 , wherein the first portion comprises a respective first end and the second portion comprises a respective second end claim 1 , the intermediate portion comprising a respective central portion of the electrode.4. The collision cell multipole of claim 3 , wherein the central portion is radially closest to the central axis.5. The collision cell multipole of claim 3 , wherein the first and second ends are radially furthest from the central axis.6. The collision cell multipole of claim 1 , wherein the first and second portions are a radial distance of 4.5 mm from the central axis.7. The collision cell ...

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Номер записи: 13
24-01-2019 дата публикации

HIGH-SPEED LOW-NOISE ION CURRENT DETECTION CIRCUIT AND MASS SPECTROMETER USING THE SAME

Номер: US20190027348A1
Автор: HEGDE Anoop, Pandurangan Anand, Selvaraj Siva
Принадлежит: ATONARP INC.

Methods and circuits for detecting an ion current in a mass spectrometer are described. A circuit and a method may involve converting, over a length of integration time, the ion current to a voltage ramp by an integrating circuit having a gain setting. The circuit and the method may also involve determining a slope of the voltage ramp. The circuit and the method may also involve determining a magnitude of the ion current based on the slope of the voltage ramp and the gain setting. The circuit and the method may further involves determining an out-of-range state based on the voltage ramp and adjusting the gain setting of the integrating circuit, or the length of integration time or both, in response to the determining of the out-of-range state. 1. A method of detecting an ion current in a mass spectrometer , comprising:converting, over a length of integration time, the ion current to a voltage ramp by an integrating circuit having a gain setting; 'digitizing, by an analog-to-digital converter (ADC), the voltage ramp into a plurality of voltage samples, the plurality of voltage samples representing the voltage ramp; and', 'determining a slope of the voltage ramp byanalyzing, by a processor, the plurality of voltage samples to determine the slope of the voltage ramp;determining a magnitude of the ion current based on the slope of the voltage ramp and the gain setting; anddetermining an out-of-range (OOR) state based on the voltage ramp and a predetermined detectable range; andadjusting the gain setting of the integrating circuit, the length of integration time, or both, in response to the determining of the OOR state such that the voltage ramp is within the predetermined detectable range at an end time of the length of integration time.2. The method of claim 1 , wherein the analyzing of the plurality of voltage samples to determine the slope of the voltage ramp comprises:determining a first-order fitting line based on the plurality of voltage samples; anddesignating a ...

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Номер записи: 14
24-01-2019 дата публикации

MASS ANALYSIS APPARATUS AND METHOD

Номер: US20190027349A1
Автор: MATOBA Yoshiki, OKAWA Shin, SAKUTA Masahiro
Принадлежит:

Disclosed is a mass analysis apparatus and method, wherein the precision of detection of a first material including a second material is improved, without enlarging the apparatus, and the measurement time is reduced. The mass analysis apparatus for analyzing a sample containing a first material including an organic compound and at least one second material including an organic compound and having a mass spectrum peak overlapping that of the first material includes a peak correction unit, wherein, when an intensity ratio (peak B)/(peak A) of peak A, not overlapping that of the first material, and peak B, overlapping that of the first material, is a correction coefficient (W), an intensity of a net peak D of the mass spectrum of the first material is calculated by subtracting W×(intensity of peak A) from an intensity of a peak C of the mass spectrum of the first material in the sample. 1. A mass analysis apparatus for analyzing a sample containing a first material comprising an organic compound and at least one second material comprising an organic compound and having a mass spectrum peak overlapping a mass spectrum peak of the first material , the mass analysis apparatus comprising:a peak correction unit, configured such that, when an intensity ratio (peak B)/(peak A) of peak A, which does not overlap the mass spectrum peak of the first material, and peak B, which overlaps the mass spectrum peak of the first material, among mass spectrum peaks of standard materials for the at least one second material, is a correction coefficient (W), an intensity of a net peak D of a mass spectrum of the first material is calculated by subtracting W×(intensity of peak A) from an intensity of a peak C of the mass spectrum of the first material in the sample.2. The mass analysis apparatus of claim 1 , wherein two or more second materials are present claim 1 , andthe peak correction unit subtracts a sum of W×(intensity of peak A) values for the second materials from the intensity of ...

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Номер записи: 15
24-01-2019 дата публикации

MASS SPECTROMETRY DEVICE AND ION DETECTION METHOD THEREFOR

Номер: US20190027350A1
Автор: MURAKAMI Shinichi, Terui Yasushi
Принадлежит:

An object of the invention is to provide a mass spectrometry device and an ion detection method therefor in which an ion amount can be detected with high accuracy. 1. A mass spectrometry device which performs a channel scan measurement by changing a voltage to be applied to a mass separation unit to selectively extract a desired ion , the device comprising:an ion detection unit which detects an ion separated by the mass separation unit and outputs an electric signal;an ion amount measuring unit which measures an ion amount from the output of the ion detection unit; andanion amount correction unit which corrects a detection amount of ion from an output of the ion amount measuring unit, whereinin a process of a channel scan, the ion amount correction unit performs correction of a detection amount of ion detected in a present channel based on a detection amount of ion in a previous channel.2. The mass spectrometry device according to claim 1 , whereinin the ion amount correction unit, an ion correction amount of the present channel is decided based on the detection amount of ion in the previous channel, a measurement time of one channel, and an interval time required for a channel switch.3. The mass spectrometry device according to claim 1 , further comprising:a correction information calculation unit which, for a plurality of measurement samples having different concentrations, measures an attenuatiion process of the detection amount of ion when ions are blocked and calculates the correction amount in association with the detection amount of ion before the ion blocking.4. The mass spectrometry device according to claim 3 , whereinthe correction information calculation unit approximates a relation between the detection amount of ion before the ion blocking and the correction amount by an expression, andthe device further includes a correction information storage unit which stores information of the derived approximate expression.5. The mass spectrometry device ...

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Номер записи: 16
02-02-2017 дата публикации

MASS SPECTROMETRY METHOD, MASS SPECTROMETRY , AND MASS SPECTROMETRIC DATA PROCESSING PROGRAM

Номер: US20170032947A1
Автор: KOBAYASHI Yuko, OGURA Tairo
Принадлежит: SHIMADZU CORPORATION

In a mass spectrometric method of the invention, a mass spectrometer () is used having a mass separation unit () before and after a collision cell () for fragmenting ions. When a product ion corresponding to a precursor ion set for a sample is selected by performing product ion scan with respect to the precursor ion, an exclusion range of mass-to-charge ratios is set based on information on non-selection ions input by a user, and a product ion that satisfies a predefined criterion is selected within a range of mass-to-charge ratios excluding the exclusion range in a product ion spectrum. According to the mass spectrometric method of the invention, product ions suited for measurement on a target compound can be selected. 1. A mass spectrometric method , using a mass spectrometer haying a mass separation unit before and after a collision cell for fragmenting ions , for selecting a product ion corresponding to a precursor ion set for a sample by performing product ion scan with respect to the precursor ion , the method comprising:a) setting one or a plurality of mass-to-charge ratios based on information on non-selection ions input by a user; andb) selecting a product ion that satisfies a predefined criterion within a range excluding the one or plurality of mass-to-charge ratios in a product ion spectrum obtained by the product ion scan.2. The mass spectrometric method according to claim 1 , wherein the one or plurality of mass-to-charge ratios are set as a range haying a width.3. The mass spectrometric method according to claim 2 , wherein the width is determined in accordance with a command input by the user.4. The mass spectrometric method according to claim 1 , wherein a number of product ions are selected claim 1 , the number being indicated by the command input by the user.5. A mass spectrometer haying a mass separation unit before and after a collision cell for fragmenting ions claim 1 , the mass spectrometer being for selecting a product ion corresponding to a ...

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Номер записи: 17
02-02-2017 дата публикации

High Pressure Mass Resolving Ion Guide With Axial Field

Номер: US20170032954A1
Автор: Giles Kevin, Green Martin Raymond, Hewitt Darren, Kenny Daniel James, Langridge David J., Pringle Steven Derek, Wildgoose Jason Lee
Принадлежит:

A mass spectrometer is disclosed comprising a first mass filter comprising a plurality of electrodes and a first device arranged and adapted to generate an axial force which drives at least some ions axially through or along the first mass filter and a quadrupole mass filter or mass analyser arranged downstream of the mass filter. 1. A mass spectrometer comprising:a first mass filter comprising a plurality of electrodes and a first device arranged and adapted to generate an axial force which drives at least some ions axially through or along said first mass filter; anda quadrupole mass filter or mass analyser arranged downstream of said mass filter.2. A mass spectrometer as claimed in claim 1 , wherein said quadrupole mass filter or mass analyser comprises an analytical mass filter or mass analyser.3. A mass spectrometer as claimed in claim 1 , wherein said first mass filter is arranged and adapted to be operated in a substantially synchronised manner with said quadrupole mass filter or mass analyser.4. A mass spectrometer as claimed in claim 1 , wherein said first mass filter is arranged and adapted to be operated so as to substantially restrict or reduce the ion current transmitted to said quadrupole mass filter or mass analyser.5. A mass spectrometer as claimed in claim 1 , wherein said first mass filter and said quadrupole mass filter or mass analyser are arranged and adapted to be operated in a mode of operation wherein said first mass filter is arranged to mass filter ions with a first mass resolution Rand wherein at substantially the same time Tsaid quadrupole mass filter or mass analyser is arranged to mass filter ions with a second mass resolution R claim 1 , wherein R>R.6. A mass spectrometer as claimed in claim 5 , wherein said first mass resolution R=(m/z)/Wwherein m/z is the mass to charge ratio of an ion peak and Wis the ion peak width at half height and wherein said second mass resolution R=(m/z)/Wwherein m/z is the mass to charge ratio of an ion peak ...

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Номер записи: 18
04-02-2016 дата публикации

Data Dependent Control of the Intensity of Ions Separated in Multiple Dimensions

Номер: US20160035551A1
Автор: Green Martin Raymond, Richardson Keith, Wildgoose Jason Lee
Принадлежит:

A method of mass spectrometry is disclosed comprising setting an attenuation factor of an attenuation device to a first value and then separating or filtering ions according to a first physico-chemical property and separating or filtering ions according to a second physico-chemical property and obtaining a multi-dimensional array of data. The most intense ion peak within one or more subsets of the multi-dimensional array of data is determined. If it is determined that the most intense ion peak would cause saturation of an ion detector or ion detection system then the method further comprises adjusting the attenuation factor of the attenuation device to a second value and obtaining mass spectral data wherein the adjustment of the attenuation factor substantially alters the intensity of all ions which are detected by the ion detector or ion detection system equally and irrespective of the mass to charge ratio of the ions. The intensity of the mass spectral data is then scaled based upon the degree to which the attenuation factor of the attenuation device was increased or reduced. 1. A method of mass spectrometry comprising:setting an ionisation efficiency of an ion source to a first value or setting an attenuation factor of an attenuation device to a first value or setting a gain of an ion detector or ion detection system to a first value; and thenseparating or filtering ions according to a first physico-chemical property and separating or filtering ions according to a second physico-chemical property and obtaining a multi-dimensional array of data;determining the most intense ion peak within one or more subsets of said multi-dimensional array of data; anddetermining whether or not said most intense ion peak would cause saturation of an ion detector or an ion detection system or would otherwise adversely affect the operation of said ion detector or ion detection system;wherein if it is determined that said most intense ion peak would cause saturation of said ion ...

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Номер записи: 19
31-01-2019 дата публикации

QUADRUPOLE MASS FILTER AND QUADRUPOLE TYPE MASS SPECTROMETRY DEVICE

Номер: US20190035618A1
Автор: Miyauchi Shinji, Ueda Hiroko, Ueno Yoshihiro
Принадлежит: SHIMADZU CORPORATION

A pre-electrode unit () placed in front of a main electrode unit () have a two-stage configuration. A front pre-electrode unit (A) and rear pre-electrode unit (B) are respectively supplied with radio-frequency voltages whose frequency is the same as that of a radio-frequency voltage applied to rod electrodes in the main electrode unit (), and whose amplitude decreases in a stepwise manner toward the front side. Decreasing the amplitude of a radio-frequency voltage increases the ion acceptance. Therefore, by appropriately adjusting the amplitudes, the matching between the emittance of an incoming ion beam and the acceptance can be improved. The ion transmittance of the entire quadrupole mass filter () is significantly affected by the ion transmittance at the point of entry of the ion into the pre-electrode unit () as well as the ion transmittance at the point of entry of the ion from the pre-electrode unit () into the main electrode unit (), rather than the ion transmittance within the pre-electrode unit (). Therefore, the ion transmittance of the quadrupole mass filter () can be enhanced by improving those transmittances. 1. A quadrupole mass filter comprising:a) a main electrode unit including a plurality of rod electrodes arranged in such a manner as to surround a central axis;b) a pre-electrode unit placed in front of the main electrode unit along the central axis, the pre-electrode unit including a plurality of electrode sets separated from each other along the central axis, where each of the electrode sets includes a plurality of electrodes arranged in such a manner as to surround the central axis;c) a first electrode supplier for applying voltages to the rod electrodes of the main electrode unit, respectively, where each of the voltages is generated by adding a direct-current voltage and a radio-frequency voltage and corresponds to the mass-to-charge ratio of an ion to be allowed to pass through; andd) a second voltage supplier for applying radio-frequency ...

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Номер записи: 20
30-01-2020 дата публикации

ION DETECTION DEVICE AND MASS SPECTROMETER

Номер: US20200035474A1
Автор: NISHIGUCHI Masaru
Принадлежит: SHIMADZU CORPORATION

An ion detector () includes a shield electrode () between an aperture plate () and a conversion dynode (). The shield electrode () has a rectilinearly-moving particle block wall () positioned on an extension line (C′) extending from the central axis (C) of a quadrupole mass filter (), and an ion attracting electric field adjustment wall () inclined by a predetermined angle θ (acute angle) with respect to the extension line (C′). In the ion attracting electric field adjustment wall () is provided an ion passing aperture (). The rectilinearly-moving particles, such as neutral particles, which are ejected from the quadrupole mass filter (), are blocked by the rectilinearly-moving particle block wall (), thereby reducing noises caused by the rectilinearly-moving particles. Meanwhile, the potential of the ion attracting electric field adjustment wall () corresponds to equipotential surfaces in a strong electric field formed by the conversion dynode (), and thus the condition of the strong electric field is not remarkably changed from the state where no shield electrode () is provided. Therefore, the effect of drawing ions is exhibited, thereby maintaining the high ion-detection efficiency.

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Номер записи: 21
24-02-2022 дата публикации

ION MOBILITY SEPARATION SYSTEM WITH ROTATING FIELD CONFINEMENT

Номер: US20220057363A1
Автор: Prabhakaran Aneesh
Принадлежит:

An ion mobility separator includes an ion path with a central axis along which ions travel, the ion path containing a gas. A first force is applied to the ions in a first axial direction, and a second force that varies spatially along the ion path is applied to the ions in second axial direction opposite the first axial direction. A rotating confinement field has a radially-inhomogeneous electric potential with relative maxima and minima that rotate about the central axis as a function of time, the confinement field exerting a radial confinement force on the ions in a radial direction toward the central axis. The ion mobility separator may be operated at elevated pressures including ambient pressure and higher. The first and/or second axial forces may be a constant or gradient gas flow, a constant or gradient electric field or an axial component of the rotating confinement field. 1. A trapped ion mobility separator comprising:an ion path along which ions travel from an entrance to an exit along a first axial direction relative to a central axis of the ion path, the ion path containing a gas through which the ions pass;a first force-generating apparatus that exerts a first force on the ions in the first axial direction;a second force-generating apparatus that exerts a second force on the ions in a second axial direction opposite to the first axial direction, wherein at least one of the first and second forces varies spatially along the first axial direction such that ions are trapped and separated by ion mobility along said first axial direction during an accumulation phase, and wherein at least one of the first and second forces is varied during an elution phase to increase a magnitude of the first force relative to the second force over time such that the ions are progressively driven to the exit of the ion path as a function of ion mobility; anda rotating confinement field-generating apparatus that generates a radially-inhomogeneous electric potential that exerts ...

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Номер записи: 22
24-02-2022 дата публикации

Automated Ion Optics Charging Compensation

Номер: US20220059334A1
Автор: Bradley Schneider, Leigh BEDFORD, Yang Kang, Yves Le Blanc
Принадлежит: DH TECHNOLOGIES DEVELOPMENT PTE LTD

In some embodiments, a method for optimizing performance of a mass spectrometer comprises using an ion source to generate ions, collisionally cooling the ions within an ion guide, directing said ions from the ion guide through at least one ion lens to a downstream mass analyzer, ramping a DC voltage applied to the ion lens, performing a mass analysis of the ions within the mass analyzer while the DC voltage applied to the ion lens is ramped, estimating performance of the mass spectrometer by measuring one or more characteristics of at least one of an ion signal and the voltage ramp, and adjusting a DC voltage applied to said at least one lens element based on said measured one or more characteristics of at least one of the ion signal and the voltage ramp so as to enhance performance of the mass spectrometer.

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Номер записи: 23
24-02-2022 дата публикации

MULTIPOLE DEVICE AND MANUFACTURING METHOD

Номер: US20220059335A1
Автор: Bloomfield Stephen, GILL Matthew, WITTER Richard
Принадлежит: SHIMADZU CORPORATION

A method of manufacturing a multipole device includes the steps of: (a) forming an intermediate device by assembling a plurality of components including a plurality of precursor multipole electrodes, wherein the plurality of precursor multipole electrodes in the assembled device extend along and are distributed around a central axis; (b) forming a multipole device from the intermediate device by machining the precursor multipole electrodes within the intermediate device to provide a plurality of multipole electrodes having a predetermined spatial relationship; wherein a first component of the multipole device that includes a multipole electrode is attached non-permanently to a second component of the multipole device, the first component including a first alignment formation, and the second component including a second alignment portion configured to engage with the first alignment formation on the first component so as to facilitate alignment of the first component and the second component when the first component and the second component are attached, thereby allowing the first component to be detached from and then reattached to the second component while retaining the predetermined spatial relationship between the plurality of multipole electrodes. 2. A method according to claim 1 , wherein in step (b) the machining is in the form of wire electrical discharge machining.3. A method according to claim 1 , further including the steps of:(c) disassembling the plurality of multipole electrodes;{'claim-text': ['cleaning the plurality of multiple electrodes,', 'polishing surfaces of the plurality of multiple electrodes, and', 'plating of the plurality of multiple electrodes; and'], '#text': '(d) performing at least one processing step on the plurality of multipole electrodes, the at least one processing step including one or more of:'}(e) reassembling the plurality of multipole electrodes to reform the multipole device, in which the plurality of multipole electrodes ...

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Номер записи: 24
15-02-2018 дата публикации

Method of Screening Samples

Номер: US20180045679A1
Автор: Carver Christopher, Eatough David, GOLDING Andrew, Goshawk Jeffrey, McCullagh Michael
Принадлежит:

A method of screening a sample for at least one compound of interest is disclosed. The method comprises comparing the ion mobility and at least one further physicochemical property of the ions of a compound of interest to the same properties of candidate ions in the sample. The properties of the compound of interest are matched to those of a candidate ion in the sample then the sample may be determined to comprise the compound of interest. 1. A method of mass spectrometry or ion mobility spectrometry comprising:separating a sample using a liquid chromatography device to produce a liquid chromatography eluent;ionising the liquid chromatography eluent to produce candidate ions;determining an experimental value of retention time in the liquid chromatography device corresponding to each of the candidate ions;experimentally measuring the ion mobilities of the candidate ions using an ion mobility separator so as to obtain an experimental value corresponding to the ion mobility of each of the candidate ions;experimentally measuring the mass to charge ratios of the candidate ions so as to obtain an experimental value corresponding to the mass to charge ratio of each of the candidate ions; anddistinguishing candidate ions having substantially the same retention time and mass to charge ratio, but different ion mobility.2. The method of claim 1 , comprising experimentally measuring the mass to charge ratios of the candidate ions using a quadrupole mass analyser or a Time of Flight mass analyser.3. The method of claim 1 , further comprising fragmenting claim 1 , reacting or activating the candidate ions to produce fragment or product ions.4. The method of claim 3 , further comprising repeatedly and consecutively switching the method between a first mode and a second mode claim 3 , wherein in the first mode the mass to charge ratios of the candidate ions are measured and in the second mode the candidate ions are fragmented claim 3 , activated or reacted and the mass to charge ...

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Номер записи: 25
06-02-2020 дата публикации

METHOD FOR DESIGNING ION OPTICAL ELEMENT AND MASS SPECTROMETRY DEVICE

Номер: US20200043716A1
Автор: TANIGUCHI Junichi
Принадлежит: SHIMADZU CORPORATION

In a linear ion trap (), the shape and arrangement of four rod electrodes (-) are made to deviate from an ideal state in which only a quadrupole electric field is created, in such a manner that so that the polarity of the ratio of the strength of an octapole electric field to the strength of the quadrupole electric field is different from the polarity of the ratio of the strength of an dodecapole electric field to the strength of the quadrupole electric field, where the absolute value of each of the ratios is equal to or greater than 0.005, and the absolute value of the ratio of the strength of the octapole electric field to the strength of the dodecapole electric field is within a range from 0.5 to 1.4. By superposing the octapole electric field on the quadrupole electric field and additionally superposing the dodecapole electric field having the opposite polarity to the octapole electric field, a peak shift of a resonance curve can be canceled and a peak having a steep edge on both high-frequency and low-frequency sides can be obtained. A linear ion trap satisfying those conditions can achieve both high ion-trapping efficiency and high ion-separating power. 1. A method for designing an ion optical element including four rod electrodes arranged substantially parallel to a linear axis so as to surround the axis , the ion optical element allowing voltages to be respectively applied to the four rod electrodes to create a quadrupole electric field and a multipole electric field whose order is higher than the quadrupole electric field within a space surrounded by the rod electrodes , to trap ions within the space and subsequently perform an ion-separating operation for retaining an ion having a specific mass-to-charge ratio or ions included within a specific mass-to-charge-ratio range among the trapped ions by removing the other ions , or to perform an ion-separating operation for selectively allowing an ion having a specific mass-to-charge ratio or ions included within ...

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Номер записи: 26
16-02-2017 дата публикации

Mass Spectrometer With Interleaved Acquistion

Номер: US20170047212A1
Автор: Kenny Daniel James
Принадлежит:

A method of mass spectrometry is disclosed comprising passing ions through a first stage and a second stage of a mass spectrometer and monitoring a first ion acquisition for a first dwell time extending from a time Tto a time T+T. The method further comprises reconfiguring the mass spectrometer or one or more components of the mass spectrometer to monitor a second ion acquisition and setting the first stage to transmit ions of the second ion acquisition at a time T, wherein TT+Tand determining the time T based on a known or calculated ion transit time through one or more regions or components of the mass spectrometer disposed downstream of the first stage 1. A method of mass spectrometry comprising:passing ions through a first stage and a second stage of a mass spectrometer;{'sub': 1', '1', 'dwell1, 'monitoring a first ion acquisition for a first dwell time extending from a time Tto a time T+T;'}reconfiguring said mass spectrometer or one or more components of said mass spectrometer to monitor a second ion acquisition; and{'sub': 1', 'dwell1, 'setting said first stage to transmit ions of the second ion acquisition at a time T, wherein TT+T;'}the method further comprising determining said time T based on a known or calculated ion transit time through one or more regions or components of said mass spectrometer disposed downstream of said first stage.2. A method as claimed in claim 1 , wherein said second stage comprises an ion detector or is arranged to transmit ions to an ion detector.3. A method as claimed in claim 2 , wherein said one or more regions or components of the mass spectrometer are disposed upstream of said second stage or said ion detector.4. A method as claimed in claim 1 , wherein said ...

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Номер записи: 27
15-02-2018 дата публикации

Method of Calibrating a Mass Spectrometer

Номер: US20180047549A1
Автор: Jung Gerhard, QUAAS Norbert, SCHLUETER Hans-Juergen
Принадлежит:

A method of calibrating a mass spectrometer is disclosed. The mass spectrometer includes a first quadrupole, a second mass analyzer and a detection means. The method includes calibrating the second mass analyzer at a first time, calibrating the first quadrupole at a second time later than the first including a) determining for each of several selected masses a corresponding value of the amplitude of the RF voltage and DC voltage applied to the electrodes of the first quadrupole, b) fitting a function of the selected mass to the values of the amplitude of the RF voltage and DC voltage corresponding to the several selected masses, c) detecting the selected mass in a filter window width over a mass range, d) evaluating a shift of the peak position and/or a deviation of the filter window width, and e) repeating the calibration steps under certain conditions. 1. A method for calibrating a mass spectrometer comprising an ion source , a first mass analyzer being a first quadrupole , a second mass analyzer and a detection means to detect ions , wherein ions ejected from the ion source can be moved on trajectories to the detection means passing both mass analyzers in which they first pass the first quadrupole and afterwards the second mass analyzer or vice versa , the first quadrupole operable as a pre-selecting mass analyzer in a mass selecting mode selecting masses in a mass filter window having a filter window width w , in which a RF voltage and a DC voltage are applied to electrodes of the first quadrupole , the amplitude of the RF voltage being a first function RF(m , w) of a selected mass m and the filter window width w and the DC voltage being a second function DC(m , w) of the selected mass m and the filter window width w comprising the steps:{'sub': '1', 'i) calibrating the second mass analyzer at a first time t,'}{'sub': cal', '2', '1, 'ii) calibrating the first quadrupole in the mass selecting mode selecting masses in the mass filter window having the filter ...

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Номер записи: 28
25-02-2016 дата публикации

A Method of Screening Samples

Номер: US20160054264A1
Автор: Carver Christopher, Eatough David, GOLDING Andrew, Goshawk Jeffrey, McCullagh Michael
Принадлежит:

A method of screening a sample for at least one compound of interest is disclosed. The method comprises comparing the ion mobility and at least one further physicochemical property of the ions of a compound of interest to the same properties of candidate ions in the sample. The properties of the compound of interest are matched to those of a candidate ion in the sample then the sample may be determined to comprise the compound of interest. 1. A method of screening a sample for at least one compound of interest comprising:selecting at least one compound of interest that may be present in a sample and assigning an expected value, or range of expected values, corresponding to the ion mobility of ions produced by ionisation of the compound of interest and an expected value, or range of expected values, of at least one further physicochemical property relating to the ions produced by ionisation of the compound of interest;providing the sample to a mass spectrometer or ion mobility spectrometer;ionising the sample to produce candidate ions;experimentally measuring the ion mobilities of the candidate ions using an ion mobility separator so as to obtain an experimental value corresponding to the ion mobility of each of the candidate ions;experimentally measuring said at least one further property relating to the candidate ions; andwherein, for each type of candidate ion, the experimental value corresponding to the ion mobility and said at least one further property are compared to the ion mobility value(s) and the at least one further property value(s) relating to the ions produced by ionisation of the compound of interest, respectively.2. The method of claim 1 , comprising searching the expected value(s) of ion mobility against the experimentally measured values of ions mobilities for the candidate ions to determine matching values; orcomprising searching the expected value(s) of said further physicochemical property against the experimentally measured values of said ...

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Номер записи: 29
13-02-2020 дата публикации

TRAPPED ION MOBILITY SPECTROMETER WITH HIGH ION STORAGE CAPACITY

Номер: US20200049660A1
Автор: Betz Thomas, Park Melvin Andrew, Räther Oliver
Принадлежит:

The invention is related to a trapped ion mobility spectrometer (TIMS device) and proposes to use higher order (order N>2) linear multipole RF systems to accumulate and analyze ions at an electric DC field barrier, either pure higher order RF multipole systems or multipole RF systems with transitions from higher order towards lower order, e.g. from a linear octopolar RF system (N=4) to a linear quadrupole RF system (N=2) in front of the apex of the electric DC field barrier. 1. A trapped ion mobility analyzer comprising an RF ion guide , an electric DC field barrier and a counteracting gas flow that drives ions against the electric DC field barrier , wherein an RF field of the RF ion guide transitions from an RF field of an ion guide with stacked apertured electrodes into a quadrupolar RF field.2. The trapped ion mobility analyzer according to claim 1 , wherein the counteracting gas flow is a laminar gas flow formed by a gas-tight tube which has an inner diameter that decreases from an entrance to an exit of the tube.3. The trapped ion mobility spectrometer according to claim 2 , wherein the quadrupolar RF field is prevailing in a region of the tube adjacent to the exit.4. A mass spectrometric system comprising a trapped ion mobility analyzer and a downstream mass analyzer claim 2 ,wherein the trapped ion mobility analyzer comprises an RF ion guide, an electric DC field barrier and a counteracting gas flow that drives ions against the electric DC field barrier, andwherein an RF field of the RF ion guide transitions from an RF field of an ion guide with stacked apertured electrodes into a quadrupolar RF field.5. The mass spectrometric system according to claim 4 , wherein the mass analyzer is one of a time-of-flight mass analyzer with orthogonal ion injection claim 4 , an electrostatic ion trap claim 4 , an RF ion trap claim 4 , a quadrupole mass filter claim 4 , and an ion cyclotron frequency mass analyzer.6. The mass spectrometric system according to claim 4 , ...

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Номер записи: 30
15-05-2014 дата публикации

Triple quadrupole mass spectrometer

Номер: US20140131571A1
Автор: Manabu Shimomura
Принадлежит: Shimadzu Corp

Elements are arranged so that a straight ion-beam axis extending from an ion source through a first ion lens and a front-stage quadrupole mass filter and a straight ion-beam axis extending through the ion guide in a collision cell and a rear-stage quadrupole mass filter obliquely intersect with each other at a predetermined angle in a space between the front-stage quadrupole mass filter and the collision cell. Metastable helium molecules generated in the ion source may pass through the front-stage quadrupole mass filter but will be removed before reaching the exit of the collision cell. On the other hand, precursor ions which have passed through the front-stage quadrupole mass filter are made to bend along an inflected ion-beam axis under the influence of a direct-current electric field created by an entrance ion lens, to be efficiently introduced into the collision cell.

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Номер записи: 31
13-02-2020 дата публикации

METHODS AND APPARATUS FOR IMPROVED TANDEM MASS SPECTROMETRY DUTY CYCLE

Номер: US20200051800A1
Автор: McAlister Graeme, WEISBROD Chad R.
Принадлежит:

A method for parallel accumulation and serial fragmentation of ions, wherein ions are injected into a device capable of serial ejection using a pseudopotential barrier created by an RF voltage. In all instances, the ions may be filtered prior to accumulation in the device capable of serial ejection. In some cases this filtering may take the form of discrete isolation windows using isolation waveforms with multiple notches. In some cases these waveforms may be applied to a quadrupole mass filter. Following accumulation of the precursor ions, the initial population may be serially ejected using a pseudopotential barrier created by an RF voltage. Following serial ejection, the individual precursor ion populations are analyzed. In some cases, this analysis might involve additional rounds of ion isolation and manipulation (e.g., MSn, CID, ETD, etc.). 1. A method for mass spectrometric analysis of ions of a plurality of ion species generated by ionization of a sample , comprising:(a) isolating a plurality of portions of the ions, each portion consisting of a subset of the ion species within a respective range of mass-to-charge (m/z) values;(b) simultaneously retaining the isolated plurality of portions of the ions in an ion storage apparatus, wherein the retaining is at least partially facilitated by applying an auxiliary radio-frequency (RF) voltage waveform to a one of two electrode members of the ion storage apparatus, thereby generating a pseudopotential between the two electrode members, each electrode member either consisting of a single electrode or comprising a group of electrodes;(c) releasing the retained isolated portions of the ion species one at a time from the ion storage apparatus, the releasing comprising one or more of: varying a DC potential applied to a one of the electrode members, varying DC potentials applied to both of the electrode members, or reducing an amplitude of the applied auxiliary RF voltage waveform; and(d) fragmenting or reacting each ...

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Номер записи: 32
13-02-2020 дата публикации

TIME-OF-FLIGHT MASS SPECTROMETER AND PROGRAM

Номер: US20200051804A1
Автор: IZUMI Hideaki
Принадлежит: SHIMADZU CORPORATION

A time-of-flight mass spectrometer includes a flight tube, an ion introduction unit that is connected to the flight tube, an ion detector that detects an ion flown in the flight tube, and a control unit that controls the ion introduction unit and the flight tube, wherein: the control unit sequentially changes an accumulation state of the ion to be introduced into the flight tube by the ion introduction unit, for a plurality of measurement processes performed repeatedly. 1. A time-of-flight mass spectrometer , comprising:a flight tube;an ion introduction unit that is connected to the flight tube;an ion detector that detects an ion flown in the flight tube; anda control unit that controls the ion introduction unit and the flight tube, wherein:the control unit sequentially changes an accumulation state of the ion to be introduced into the flight tube by the ion introduction unit, for a plurality of measurement processes performed repeatedly.2. The time-of-flight mass spectrometer according to claim 1 , wherein:the ion introduction unit has an ion trap.3. The time-of-flight mass spectrometer according to claim 2 , wherein:the change in the accumulation state is performed by changing the accumulation time in the ion trap.4. The time-of-flight mass spectrometer according to claim 1 , wherein:the control unit determines an optimal accumulation state among the plurality of the accumulation states based on results of the plurality of measurement processes.5. The time-of-flight mass spectrometer according to claim 4 , wherein:after determining the optimal accumulation state, the control unit sets the optimal accumulation state more frequently than other accumulation states in changing the accumulation state.6. The time-of-flight mass spectrometer according to claim 4 , wherein:the control unit determines the optimal accumulation state based on peak intensities of at least one type of ion detection result in the results of the plurality of measurement processes.7. The time-of- ...

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Номер записи: 33
05-03-2015 дата публикации

Performance Improvements for RF-Only Quadrupole Mass Filters and Linear Quadrupole Ion Traps With Axial Ejection

Номер: US20150060658A1
Автор: Kenny Daniel James, Langridge David J.
Принадлежит:

A RF only quadrupole rod set mass filter or mass analyser and a linear quadrupole ion trap with axial ejection are disclosed comprising a first pair of rod electrodes, a second pair of rod electrodes and an energy filter. The first pair of rod electrodes is longer than the second pair of rod electrodes. Ions having desired mass to charge ratios experience fringing fields at an exit region which results in the ions possessing sufficient axial kinetic energy to be transmitted by the energy filter. Other ions possess insufficient axial kinetic energy to be transmitted by the energy filter and are attenuated. 1. A quadrupole rod set mass filter , mass analyser or ion trap comprising;a first pair of rod electrodes;a second pair of rod electrodes; andan energy filter;wherein said first pair of rod electrodes has a physical property which differs from a physical property of said second pair of rod electrodes;wherein said quadrupole rod set mass filter, mass analyser or ion trap further comprises a device arranged and adapted to apply a DC bias voltage to said first pair of electrodes or said second pair of electrodes in order to align ions with either said first pair of rod electrodes or said second pair of rod electrodes.2. A quadrupole rod set mass filter claim 1 , mass analyser or ion trap as claimed in claim 1 , wherein said DC bias voltage applied to said first or second pair of electrodes has an amplitude selected from the group consisting of: (i) <−50V; (ii) −40 to −30V; (iii) −30 to −20V; (iv) −20 to −10V; (v) −10 to 0V; (vi) 0-10V; (vii) 10-20V; (viii) 20-30V; (ix) 30-40V; (x) 40-50V; and (xi) >50V.3. A quadrupole rod set mass filter claim 1 , mass analyser or on trap as claimed in claim 1 , wherein said physical property comprises axial length; and said first pair of rod electrodes has a first axial length and said second pair of rod electrodes has a second different axial length.4. A quadrupole rod set mass filter claim 1 , mass analyser or ion trap as claimed ...

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Номер записи: 34
22-05-2014 дата публикации

Mass Spectrometer and Method of Controlling Same

Номер: US20140138536A1
Автор: Kou Junkei
Принадлежит: JEOL LTD.

A mass spectrometer and control method which achieves high-speed scanning while maintaining relatively high sensitivity. The mass spectrometer () has: an ion source () ; a collisional cell () for performing a storing operation for storing at least some of the ions () and then performing an ejecting operation for ejecting the stored ions; a second mass analyzer () for selecting desired ions; a detector () for detecting the desired ions; analog signal processing circuitry () for converting a signal from the detector () into a voltage; and an A/D converter () for sampling and converting the output voltage into a digital signal. Signals delivered from the analog signal processing circuitry () in response to two pulsed ions produced by two successive ejecting operations of the collisional cell () are at least partially overlapped temporally. 1. A mass spectrometer comprising:an ion source for ionizing a sample;an ion storage-and-ejection portion for performing a storing operation for storing at least some of the ions generated in the ion source and then performing an ejecting operation for ejecting the stored ions;a mass analyzer for selecting desired ions according to mass-to-charge ratio from the ions ejected from the ion storage-and-ejection portion;a detector for detecting the desired ions;analog signal processing circuitry for converting a signal from the detector into a voltage; andan A/D converter for sampling and converting the output voltage from the analog signal processing circuitry into a digital signal;wherein two signals delivered from the analog signal processing circuitry in response to two pulsed ions produced by two successive ejecting operations of the ion storage-and-ejection portion are at least partially overlapped temporally.2. The mass spectrometer as set forth in claim 1 , wherein said ejecting operations of said ion storage-and-ejection portion have a frequency greater than a frequency bandwidth of said analog signal processing circuitry.3. The ...

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Номер записи: 35
02-03-2017 дата публикации

Identification and Removal of Chemical Noise for Improved MS and MS/MS Analysis

Номер: US20170062199A1
Автор: Brown Jeffery Mark
Принадлежит:

A method of mass spectrometry is disclosed comprising mass analysing ions and obtaining mass spectral data and determining parent or precursor ions of interest. The method further comprises determining first adduct or chemical artefact ions which have mass to charge ratios which have a substantially linear relationship with the mass to charge ratio of the parent or precursor ions of interest and removing or attenuating the first adduct or chemical artefact ions from the mass spectral data. 1. A method of mass spectrometry comprising:mass analysing ions and obtaining mass spectral data;determining parent or precursor ions of interest;determining first adduct or chemical artefact ions which have mass to charge ratios which have a substantially linear relationship with the mass to charge ratio of said parent or precursor ions of interest; andremoving or attenuating said first adduct or chemical artefact ions from said mass spectral data.2. A method as claimed in claim 1 , further comprising progressively scanning a mass to charge ratio transmission window of a mass filter.3. A method as claimed in claim 2 , wherein said mass filter comprises a quadrupole rod set mass filter.4. A method as claimed in claim 2 , further comprising causing said mass filter to preferentially onwardly transmit said parent or precursor ions of interest and to attenuate or filter other parent or precursor ions.5. A method as claimed in claim 4 , further comprising subjecting said parent or precursor ions of interest to fragmentation or reaction so as to generate fragment or product ions.6. A method as claimed in claim 1 , wherein said first adduct or chemical artefact ions have a non-random mass to charge ratio distribution.7. A method as claimed in claim 1 , wherein said first adduct or chemical artefact ions comprise: (i) singly charged adduct ions; (ii) doubly charged adduct ions; (iii) triply charged adduct ions; (iv) quadruply charged adduct ions; or (v) adduct ions having five or more ...

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Номер записи: 36
09-03-2017 дата публикации

Hybrid Acquisition Method Incorporating Multiple Dissociation Techniques

Номер: US20170069475A1
Автор: Brown Jeffery Mark
Принадлежит:

A method is disclosed wherein parent or precursor ions are fragmented or reacted according to a first fragmentation or reaction mode, and when an ion of interest is detected the method then temporarily switches to a second mode of fragmentation or reaction. This enables a full un-biased MS/MS data set to be provided over a wide mass to charge ratio range with high-duty cycle, together with complementary detailed fragment data of interest, in a single experimental run or acquisition. 1. A method of mass spectrometry comprising:mass filtering parent or precursor ions with a mass filter;transmitting the mass filtered parent or precursor ions into a fragmentation or reaction device operating in a first fragmentation or reaction mode;fragmenting or reacting the parent or precursor ions in the fragmentation or reaction device operating in the first fragmentation or reaction mode so as to produce first fragment or product ions;wherein the mass to charge ratio, or range of mass to charge ratios, of the parent or precursor ions transmitted by the mass filter is varied with time such that parent or precursor ions of different mass to charge ratios are fragmented or reacted by the first fragmentation or reaction mode at different times;monitoring for the detection of parent or precursor ions of interest and/or first fragment or product ions of interest, and wherein if parent or precursor ions of interest and/or first fragment or product ions of interest are detected then said method further comprises:halting the variation in the mass to charge ratios transmitted by the mass filter or otherwise operating the mass filter such that the mass to charge ratio, or range of mass to charge ratios, of the parent or precursor ions transmitted by the mass filter is static or remains constant for a first period of time; and thendirecting the parent or precursor ions transmitted by the mass filter during said first period of time into a fragmentation or reaction device operating in a second ...

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Номер записи: 37
07-03-2019 дата публикации

Optimizing Quadrupole Collision Cell RF Amplitude for Tandem Mass Spectrometry

Номер: US20190074168A1
Автор: Bennett S. Kalafut, Harald Oser
Принадлежит: Thermo Finnigan LLC

A mass spectrometer includes a collision cell and a system controller. The collision cell includes a plurality of rod pairs configured to generate pseudopotential well through the application of radio frequency potentials to the rod pairs. The collision cell configured to generate a target fragment from a parent ion by colliding the parent ion with one or more gas molecules. The system controller is configured to set a radio frequency amplitude of the radio frequency potentials to a default amplitude; monitor the production of a target fragment ion while adjusting the collision energy; set the collision energy to optimize the production of the target fragment ion; apply a linear full range ramp to the radio frequency amplitude to determine an optimal radio frequency amplitude; and set the radio frequency amplitude to the optimal radio frequency amplitude for the parent ion, target fragment ion pair.

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Номер записи: 38
07-03-2019 дата публикации

DETERMINING ISOTOPE RATIOS USING MASS SPECTROMETRY

Номер: US20190074169A1
Автор: Eiler John, GRIEP-RAMING Jens, JUCHELKA Dieter, Makarov Alexander, Schwieters Johannes
Принадлежит:

The present inventive concepts relate to determining an isotope ratio using mass spectrometry. Mass spectra of ions are obtained by generating ions, guiding the ions through a device having a mass transfer function that varies with ion current, providing at least some of the ions to a mass analyser and obtaining a mass spectrum of the ions and determining the ion current of the ions provided to the mass analyser. An isotope ratio of the ions is determined for each mass spectrum. Using the determined isotope ratio and determined ion current for each mass spectrum, a calibration relationship is determined that characterises the variation of the determined isotope ratios and the measured ion currents across the mass spectra. Then, a measured isotope ratio obtained at a determined ion current is adjusted using the calibration relationship to adjust the measured isotope ratio to an adjusted isotope ratio corresponding to a selected ion current. 1. A method of determining an isotope ratio of ions from a source of ions using mass spectrometry comprising: generating ions from a first source of ions;', 'guiding the generated ions through a device having a mass transfer function that varies with ion current;', 'providing at least some of the ions to a mass analyser;', 'using the mass analyser to obtain a mass spectrum of the ions provided to the mass analyser; and', 'determining the ion current of the ions provided to the mass analyser;, 'obtaining a plurality of mass spectra of ions, wherein obtaining each mass spectrum of the plurality of mass spectra compriseswherein the mass spectra are obtained for different measured ion currents;determining an isotope ratio of ions provided to the mass analyser from each mass spectrum;using the determined isotope ratio and determined ion current for each mass spectrum to determine a calibration relationship that characterises a variation of the determined isotope ratios and the measured ion currents across the mass spectra; andadjusting ...

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Номер записи: 39
16-03-2017 дата публикации

Systems and Methods for Ion Separation

Номер: US20170076928A1
Автор: UGAROV Mikhail V.
Принадлежит:

A system for analyzing a sample includes a source configured to generate ions from constituent components of the sample; a mobility separation device, a plurality of ion channels, and a mass analyzer configured to determine the mass-to-charge ratio of the ions. The mobility device is configured to separate ions received from the source based on the mobility in a gas. The mobility separation device provides a gas flow in a first direction and an electric field gradient along a second direction such that ions move in the first direction and drift according to their mobility in the second direction and are sorted based on their respective mobility. The ion channels are arranged adjacent to the mobility separation device such that ions from the mobility separation device are directed to different channels according to their respective mobility. 1. A system for analyzing a sample comprising:a source configured to generate ions from constituent components of the sample;a mobility separator configured to separate ions received from the source based on the mobility in a gas; the mobility separator providing a gas flow in a first direction and an electric field gradient along a second direction such that ions move in the first direction and drift according to their mobility in the second direction such that the ions are sorted based on their respective mobility;a plurality of ion channels arranged adjacent to the mobility separator such that ions from the mobility separator are directed to different channels according to their respective mobility; anda mass analyzer configured to determine the mass-to-charge ratio of the ions.2. The system of claim 1 , wherein an angle between the first direction and the second direction is between about 45° and about 135°.3. (canceled)4. The system of claim 2 , wherein the first direction and the second direction are orthogonal.5. The system of claim 1 , wherein the ion channels are selected from the group consisting of RF ion guides claim ...

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Номер записи: 40
05-03-2020 дата публикации

Mass filter having extended operational lifetime

Номер: US20200075308A1
Автор: Daniel KENNY, David Langridge, Jason WILDGOOSE, Keith Richardson, Kevin Giles, Martin Green, Richard Moulds
Принадлежит: Micromass UK Ltd

A mass filter is disclosed having at least one electrode ( 42 - 48 ) comprising an aperture ( 43 ) or recess. Voltages are applied to the electrodes ( 42 - 48 ) of the mass filter such that ions having mass to charge ratios in a desired range are confined by the electrodes and are transmitted along and through the mass filter, whereas ions ( 47,49 ) having mass to charge ratios outside of said desired range are unstable and pass into the aperture ( 43 ) or recess such that they are filtered out by the mass filter. The aperture ( 43 ) or recess reduces or eliminates the number of ions that would otherwise impact the electrode surface facing the ion transmission axis and hence reduces degradation of the ion transmission properties of the mass filter.

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Номер записи: 41
18-03-2021 дата публикации

QUADRUPOLE DEVICES

Номер: US20210082679A1
Автор: GORDON David, Green Martin Raymond, Langridge David
Принадлежит:

A method of operating a quadrupole device is disclosed. The method comprises applying a main drive voltage to the quadrupole device and applying three or more auxiliary drive voltages to the quadrupole device. The three or more auxiliary drive voltages correspond to two or more pairs of X-band or Y-band auxiliary drive voltages. 1. A method of operating a quadrupole device comprising:applying a main drive voltage to the quadrupole device; andapplying three or more auxiliary drive voltages to the quadrupole device;wherein the three or more auxiliary drive voltages correspond to two or more pairs of X-band or Y-band auxiliary drive voltages.2. A method as claimed in claim 1 , wherein:each of the three or more auxiliary drive voltages has a different frequency to the main drive voltage; and/orthe three or more auxiliary drive voltages comprise three or more auxiliary drive voltages having at least three different frequencies.3. A method as claimed in claim 1 , further comprising applying one or more DC voltages to the quadrupole device.4. A method as claimed in claim 1 , wherein:the main drive voltage has a frequency Ω; and{'sub': ex1', 'ex2', 'ex1', 'ex2', 'ex1', '1', 'ex2', '2', '1', '2, 'the three or more auxiliary drive voltages comprise a first pair of auxiliary drive voltages comprising a first auxiliary drive voltage having a first frequency ω, and a second auxiliary drive voltage having a second frequency ω, wherein the main drive voltage frequency Ω and the first and second frequencies ω, ωare related by ω=vΩ, and ω=vΩ, where vand vare constants; and/or'}{'sub': ex3', 'ex4', 'ex3', 'ex4', 'ex3', '3', 'ex4', '4', '3', '4, 'the three or more auxiliary drive voltages comprise a second pair of auxiliary drive voltages comprising a third auxiliary drive voltage having a third frequency ω, and a fourth auxiliary drive voltage having a fourth frequency ω, wherein the main drive voltage frequency Ω and the third and fourth frequencies ω, ωare related by ω=vΩ, and ω=v ...

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Номер записи: 42
18-03-2021 дата публикации

QUADRUPOLE DEVICES

Номер: US20210082680A1
Автор: David Gordon, Green Martin Raymond, Kenny Daniel J., Langridge David, Moulds Richard, Worthington Kenneth
Принадлежит:

A method of operating a quadrupole device is disclosed. The method comprises operating the quadrupole device in a first mode of operation, wherein ions within a first mass to charge ratio range are selected and/or transmitted by the quadrupole device, and operating the quadrupole device in a second mode of operation, wherein ions within a second different mass to charge ratio range are selected and/or transmitted by the quadrupole device. In the first mode of operation, the quadrupole device is operated in a normal mode of operation wherein a main drive voltage is applied to the quadrupole device, or in a first X-band or Y-band mode of operation wherein a main drive voltage and two or more auxiliary drive voltages are applied to the quadrupole device. In the second mode of operation, the quadrupole device is operated in a second X-band or Y-band mode of operation wherein a main drive voltage and two or more auxiliary drive voltages are applied to the quadrupole device. 1. A method of operating a quadrupole device comprising:operating the quadrupole device in a first mode of operation, wherein ions within a first mass to charge ratio range are selected and/or transmitted by the quadrupole device; andoperating the quadrupole device in a second mode of operation, wherein ions within a second different mass to charge ratio range are selected and/or transmitted by the quadrupole device;wherein operating the quadrupole device in the first mode of operation comprises operating the quadrupole device in a normal mode of operation wherein a main drive voltage is applied to the quadrupole device, or operating the quadrupole device in a first X-band or Y-band mode of operation wherein a main drive voltage and two or more auxiliary drive voltages are applied to the quadrupole device; andwherein operating the quadrupole device in the second mode of operation comprises operating the quadrupole device in a second X-band or Y-band mode of operation wherein a main drive voltage and ...

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Номер записи: 43
14-03-2019 дата публикации

High frequency voltage supply control method for multipole or monopole analysers

Номер: US20190080892A1
Автор: David R. Gordon, Kenneth Russell Worthington, Richard Barrington MOULDS
Принадлежит: Micromass UK Ltd

A voltage supply system for supplying an RF voltage to an RF resonant load comprising an ion-optical component of a mass spectrometer is disclosed. The system comprises a Direct Digital Synthesiser (“DDS”) arranged and adapted to output an RF voltage. The voltage supply system is arranged and adapted: (i) to vary the frequency of the RF voltage output by the Direct Digital Synthesiser, (ii) to determine a first resonant frequency of the RF resonant load comprising the ion-optical component, and (iii) to determine whether or not the generation of an RF voltage at the first resonant frequency by the Direct Digital Synthesiser would also result in the generation of a spur frequency close to the first resonant frequency. If it is determined that a spur frequency would be generated close to the first resonant frequency then the voltage supply system is further arranged and adapted: (iv) to consult a look-up table comprising one or more preferred frequencies, and (v) to direct the Direct Digital Synthesiser to generate an RF voltage at a second frequency which corresponds with one of the preferred frequencies from the look-up table, wherein the second frequency is different to said first resonant frequency.

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Номер записи: 44
23-03-2017 дата публикации

MASS SPECTROMETER

Номер: US20170084447A1
Автор: Makarov Alexander, ROTTMANN Lothar, SCHLUETER Hans-Juergen, Wehe Christoph
Принадлежит:

An elemental mass spectrometer uses a mass filter to select ions from ions received from an ion source and transmit the selected ions. A reaction or collision cell receives the transmitted ions and reacts or collides these with a gas to provide product ions thereby. A mass analyzer receives the product ions, analyzes them and provides at least one output based on detection of the analyzed ions. The elemental mass spectrometer is operated to provide a first output from the mass analyzer measuring ions within a first analysis range of mass-to-charge ratios including a desired mass-to-charge ratio, M, to provide a second output from the mass analyzer measuring ions within a second analysis range of mass-to-charge ratios including a mass-to-charge ratio at least 0.95 atomic mass units lower than the desired mass-to-charge ratio, (M−i), i≧0.95 and to correct the first output on the basis of the second output. 1. An elemental mass spectrometer , comprising:an ion source for generating ions;a mass filter, arranged to receive ions generated by the ion source, to select ions of a filter range of mass-to-charge ratios from the received ions and to transmit the selected ions;a reaction or collision cell, configured to receive ions transmitted by the mass filter and to react or collide the received ions with a gas and provide product ions thereby;a mass analyzer, arranged to receive the product ions from the reaction or collision cell, to analyze the received ions within one or more analysis ranges of mass-to-charge ratios and to provide at least one output based on detection of the analyzed ions; anda controller, configured to operate the elemental mass spectrometer, so as to provide a first output from the mass analyzer measuring ions within a first analysis range of mass-to-charge ratios including a desired mass-to-charge ratio, M, to provide a second output from the mass analyzer measuring ions within a second analysis range of mass-to-charge ratios including a mass-to- ...

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Номер записи: 45
31-03-2022 дата публикации

Quantification of Processing Chamber Species by Electron Energy Sweep

Номер: US20220102123A1
Автор: Hummel Michael, Schlechte Charles, Ventzek Peter, Zhao Jianping
Принадлежит:

A plasma processing system includes a plasma chamber configured to contain a plasma, a shutter chamber fluidically coupled to the plasma chamber via a first orifice, a mass spectrometer fluidically coupled to the shutter chamber, and a shutter disposed in the shutter chamber between the first orifice and the mass spectrometer in the path of a particle beam. The first orifice is configured to generate the particle beam from the plasma using a pressure differential between the shutter chamber and the plasma chamber. The mass spectrometer includes an ionizer configured to ionize species of the particle beam by sweeping through a range of electron energies in a plurality of energy steps. The shutter is configured to open and close during each of the plurality of energy steps. 1. A plasma processing system comprising:a plasma chamber configured to contain a plasma;a shutter chamber fluidically coupled to the plasma chamber via a first orifice, the first orifice being configured to generate a particle beam from the plasma using a pressure differential between the shutter chamber and the plasma chamber;a mass spectrometer fluidically coupled to the shutter chamber, the mass spectrometer comprising an ionizer configured to ionize species of the particle beam by sweeping through a range of electron energies in a plurality of energy steps; anda shutter disposed in the shutter chamber between the first orifice and the mass spectrometer in the path of the particle beam, the shutter being configured to open and close during each of the plurality of energy steps.2. The plasma processing system of claim 1 , further comprising:a quiescence chamber disposed between the shutter chamber and the mass spectrometer, the quiescence chamber being fluidically coupled to the shutter chamber via a second orifice in the path of the particle beam;a first vacuum pump fluidically coupled to the shutter chamber; anda second vacuum pump fluidically coupled to the quiescence chamber.3. The plasma ...

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Номер записи: 46
31-03-2022 дата публикации

DALY DETECTOR OPERABLE IN NEGATIVE ION AND POSITIVE ION DETECTION MODES

Номер: US20220102125A1
Автор: LI Linfan, SCHWARTZ Jae C., SILIVRA Oleg
Принадлежит:

An ion detector that can detect either positive or negative ions comprises: an ion inlet comprising an ion focusing lens; a dynode having a surface configured to intercept, within a zone of interception, a stream of ions passing through the ion focusing lens, wherein a plane that is tangent to the dynode surface at the zone of interception is disposed at an angle to a line that passes through the center of the dynode surface and the center of the focusing lens; a scintillator having a surface that is configured to receive secondary electrons emitted from the zone of interception; a scintillator electrode affixed to the scintillator surface; a photodetector configured to receive photons emitted by the scintillator and to generate an electric signal in response thereto; and one or more power supplies electrically coupled to the focusing lens, the dynode, the scintillator electrode and the photodetector. 1. An ion detector comprising:an ion inlet comprising an ion focusing lens;a dynode having a surface configured to intercept, within a zone of interception, a stream of ions passing through the ion focusing lens, wherein a plane that is tangent to the dynode surface at the zone of interception is disposed at an angle to a line that passes through the center of the dynode surface and the center of the focusing lens;a scintillator having a surface that is configured to receive secondary electrons emitted from the zone of interception;a scintillator electrode affixed to the scintillator surface;a photodetector configured to receive photons emitted by the scintillator and to generate an electric signal in response thereto; andone or more power supplies electrically coupled to the focusing lens, the dynode, the scintillator electrode and the photodetector.2. An ion detector as recited in claim 1 , wherein the angle is within the range of twenty degrees to thirty degrees claim 1 , inclusive.3. An ion detector as recited in claim 1 , wherein the dynode surface is a concave ...

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Номер записи: 47
12-03-2020 дата публикации

OPTIMIZED STEPPED COLLISION ENERGY SCHEME FOR TANDEM MASS SPECTROMETRY

Номер: US20200083031A1
Автор: Remes Philip M.
Принадлежит:

A method for mass spectrometry comprises: receiving or generating a respective value of an optimal collision energy for generating each one of a plurality of n product-ion species of interest from at least one precursor-ion species, each optimal collision energy corresponding to a respective maximum fragmentation efficiency; determining a number, m, wherein m Подробнее

Номер записи: 48
12-03-2020 дата публикации

Method for simultaneous multicomponent analysis using mass spectrometry and mass spectrometer

Номер: US20200083032A1
Автор: Riki KITANO
Принадлежит: Shimadzu Corp

In a simultaneous multicomponent analysis for a number of target compounds, an MRM transition which does not give the highest signal intensity but gives a lower signal intensity is selected for a compound having a high measurement sensitivity or a compound having a high measurement target concentration. If the signal intensity is still high, the level of collision energy (CE) is changed from an optimum level. The MRM transition, CE level and other measurement conditions determined for each compound in this manner are stored in a compound-related information storage 41. In the process of preparing a control sequence for the simultaneous multicomponent analysis, the measurement conditions stored in the storage section 41 are used. The use of those conditions prevents the saturation of the signal for a high-concentration compound while ensuring a sufficiently high level of sensitivity for a low-concentration compound.

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Номер записи: 49
12-03-2020 дата публикации

METHODS AND SYSTEMS FOR DETECTION OF ION SPATIAL DISTRIBUTION

Номер: US20200083035A1
Автор: CHEN TSUNG-CHI
Принадлежит: Thermo Finnigan LLC

A method of performing mass spectrometric analyses, comprises: (a) passing a stream of ions through a quadrupole mass analyzer; (b) intercepting a flux of ions emitted from an exit aperture of the quadrupole mass analyzer at a front face of a stack of multichannel plates and emitting a flux of electrons in response to the intercepted flux of ions at a rear face of the stack of multichannel plates; (c) intercepting the flux of electrons at a front surface of a scintillator comprising a phosphorescent material and emitting a flux of photons in response to the intercepted flux of ions at a rear surface of the scintillator; (d) receiving the flux of photons at a photo-imager; and (e) repositioning at least one of the scintillator and the stack of microchannel plates during the execution of one or more of the steps (a) through (d). 1. A method of performing mass spectrometric analyses , comprising:(a) passing a stream of ions through a quadrupole mass analyzer;(b) intercepting a flux of ions emitted from an exit aperture of the quadrupole mass analyzer at a front face of a stack of multichannel plates and emitting a flux of electrons in response to the intercepted flux of ions at a rear face of the stack of multichannel plates;(c) intercepting the flux of electrons at a front surface of a scintillator comprising a phosphorescent material and emitting a flux of photons in response to the intercepted flux of ions at a rear surface of the scintillator;(d) receiving the flux of photons at a photo-imager; and(e) repositioning at least one of the scintillator and the stack of microchannel plates during the execution of one or more of the steps (a) through (d).2. A method of performing mass spectrometric analyses as recited in claim 1 , wherein the intercepting of the flux of electrons at the front surface of a scintillator comprises intercepting the flux of electrons at the front surface of a single crystal plate of cerium-doped gadolinium aluminum gallium garnet (Ce:GAGG).3. ...

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Номер записи: 50
25-03-2021 дата публикации

Fast continuous srm acquisitions with or without ion trapping

Номер: US20210090869A1
Автор: Mikhail V. UGAROV
Принадлежит: Thermo Finnigan LLC

A mass spectrometer includes an ion source, an ion guide, a first gate, first and second mass filters, a fragmentation cell, a detector, and a controller. The ion source is configured to produce an ion beam from a sample. The first and second mass filters are configured to selectively transmit ions within a mass-to-charge range and reject ions outside of the mass-to-charge range. The detector is configured to measure the intensity of the transmitted ion beam. The controller is configured to close the first ion gate to prevent ions from entering the first mass filter, switch a first quadrupole voltage of the first mass filter to a voltage of a first transition, and open the first ion gate to allow ions to enter the first mass filter, the opening offset from the switching by at least the time required to adjust the voltage of the first mass filter.

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Номер записи: 51
29-03-2018 дата публикации

Methods for calibration of a quadrupole mass filter

Номер: US20180090304A1
Автор: Bennett S. Kalafut
Принадлежит: Thermo Finnigan LLC

The linear relationship between physical mass-to-charge ratio and the location of a mass spectral peak along the DC/RF scan line of a quadrupole mass filter is used to simultaneously identify a known set of calibrants and to determine the correct slope and scaling of the scan line from a full spectrum scan of an uncalibrated instrument. This is achieved by using a method for image feature detection, to find a set of collinear peaks in a two-dimensional image constructed from scaled versions of the mass spectrum. The method for feature detection may include a Hough transform, Radon transform or other machine-vision technique.

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Номер записи: 52
09-04-2015 дата публикации

METHOD AND APPARATUS FOR A COMBINED LINEAR ION TRAP AND QUADRUPOLE MASS FILTER

Номер: US20150097115A1
Автор: SCHWARTZ Jae C.
Принадлежит: Thermo Finnigan LLC

An apparatus for a mass spectrometer comprises: a set of four rod electrodes defining an ion occupation volume therebetween having entrance and exit ends, at least one of the rod electrodes having a slot passing therethrough; first and second ion optics disposed adjacent to the entrance and exit ends, respectively; a voltage supply system; and at least one supplemental electrode disposed at least partially within the at least one slot, wherein the voltage supply system is configured so as to supply a radio-frequency (RF) voltage, a direct-current (DC) filtering voltage and an oscillatory dipole resonant ejection voltage across members of the set of rod electrodes and so at to supply a secondary ion-trapping RF voltage and a secondary DC filtering voltage to the at least one supplemental electrode and to supply DC voltages across the rod electrodes and each of the first and second ion optics. 1. An apparatus comprising:a set of four substantially parallel rod electrodes having an ion occupation volume therebetween having an entrance end and an exit end, at least one of the rod electrodes having a slot passing therethrough;first and second ion optics disposed adjacent to the entrance and exit ends, respectively;a voltage supply system; andat least one supplemental electrode disposed at least partially within the at least one slot,wherein the voltage supply system is configured so as to supply a radio-frequency (RF) voltage, a direct-current (DC) filtering voltage and an oscillatory dipole resonant ejection voltage across members of the set of rod electrodes and so as to supply a secondary RF voltage and a secondary DC filtering voltage to the at least one supplemental electrode and to supply DC voltages across the rod electrodes and each of the first and second ion optics.2. An apparatus as recited in claim 1 , wherein each supplemental electrode is recessed within the slot within which it is disposed with respect to an end of the said slot that faces the ion ...

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Номер записи: 53
16-04-2015 дата публикации

Electrode device with pre- and/or postfilters and manufacturing method therefor, as well as a mass spectrometer with such an electrode device

Номер: US20150102213A1
Автор: Bernd Laser, Carsten LASER, Frank Schaefer
Принадлежит: VACUTEC HOCHVAKUUM- & PRÄZISIONSTECHNIK GMBH

A method manufactures a multipolar electrode device, in particular a multipole for use in a mass spectrometer, wherein the electrode device includes at least one main filter and at least one pre- and/or postfilter. The electrode blanks are separated in several sections for producing the pre- and/or postfilters, which are thereby maintained by a holder in a constant relative position to each other. Moreover, an electrode device may be used in a mass spectrometer and a mass spectrometer may have such a multipolar electrode device.

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Номер записи: 54
16-04-2015 дата публикации

TANDEM QUADRUPOLE MASS SPECTROMETER

Номер: US20150102219A1
Автор: Yamamoto Hideki
Принадлежит: SHIMADZU CORPORATION

Prior to multiple reaction monitoring (MRM) measurement condition optimization, an analysis operator prepares, for each precursor ion of an objective compound, two lists on a product-ion selection condition setting screen , i.e. a list which shows ions to be preferentially selected as product ions for which the optimization needs to be performed and a list which shows ions to be excluded from the optimization. When a measurement is performed, a product-ion scan measurement for the precursor ion of the objective compound is performed and a spectrum is obtained. Among the ions extracted from this spectrum, any ion registered in the excludable-ion list is excluded, while any ion registered in the preferred-ion list is preferentially selected as a product ion. For each combination of the m/z values of the precursor ion and the product ions thus determined, optimum conditions of the MRM measurement are searched for. 1. A tandem quadrupole mass spectrometer having front-stage and rear-stage quadrupole mass filters with a collision cell for fragmenting an ion in between , the tandem quadrupole mass spectrometer having a function of performing a multiple reaction monitoring (MRM) measurement condition optimization for searching for an optimum MRM measurement condition for one or a plurality of compounds while conducting an MRM measurement of a sample , and the tandem quadrupole mass spectrometer comprising:a) a preferred ion registry for registering a mass-to-charge ratio of one or a plurality of product ions to be preferentially selected as a target, for each precursor ion, as a measurement condition for optimizing the MRM measurement condition; andb) an MRM measurement condition optimizer for performing the MRM measurement condition optimization for a target precursor ion originating from one compound by retrieving information about a preferred product ion for the precursor ion from the preferred ion registry, and if the preferred product ion is detected as a product ion ...

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Номер записи: 55
05-04-2018 дата публикации

RF/DC FILTER TO ENHANCE MASS SPECTROMETER ROBUSTNESS

Номер: US20180096832A1
Автор: Hager James W.
Принадлежит:

Systems and methods described herein utilize a multipole ion guide that can receive ions from an ion source for transmission to downstream mass analyzers, while preventing unwanted/interfering/contaminating ions from being transmitted into the high-vacuum chambers of mass spectrometer systems. In various aspects, RF and/or DC signals can be provided to auxiliary electrodes interposed within a quadrupole rod set so as to control or manipulate the transmission of ions from the multipole ion guide. 1. A mass spectrometer system , comprising:an ion source for generating ions;an ion guide chamber, the ion guide chamber comprising an inlet orifice for receiving the ions generated by the ion source and at least one exit aperture for transmitting ions from the ion guide chamber into a vacuum chamber housing at least one mass analyzer; i) a quadrupole rod set extending from a proximal end disposed adjacent the inlet orifice to a distal end disposed adjacent the exit aperture, the quadrupole rod set comprising a first pair of rods and a second pair of rods, wherein each rod is spaced from and extends alongside a central longitudinal axis, and', 'ii) a plurality of auxiliary electrodes spaced from and extending alongside the central longitudinal axis along at least a portion of the quadrupole rod set, the plurality of auxiliary electrodes interposed between the rods of the quadrupole rod set such that the auxiliary electrodes are separated from one another by a rod of the quadrupole rod set and such that each of the auxiliary electrodes is adjacent to a single rod of the first pair of rods and a single rod of the second pair of rods; and, 'a multipole ion guide disposed in the ion guide chamber, the multipole ion guide comprisinga power supply coupled to the multipole ion guide operable to provide i) a first RF voltage to the first pair of rods at a first frequency and in a first phase, ii) a second RF voltage to the second pair of rods at a second frequency equal to the first ...

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Номер записи: 56
12-05-2022 дата публикации

ION DETECTOR CURRENT CONVERTER

Номер: US20220148869A1
Автор: Lerche Heinz
Принадлежит:

A conversion circuit is arranged for converting an ion detection current (i) produced by an ion detector into an ion detection signal (P). The conversion circuit comprises: 1. A conversion circuit for converting an ion detection current produced by an ion detector into an ion detection signal , the conversion circuit comprising:an input stage for converting the ion detection current into an ion detection voltage, andan output stage for converting the ion detection voltage into the detection signal, the output stage being arranged for drawing a first current dependent on the ion detection voltage,wherein the conversion circuit further comprises:a supplementary stage for providing a second current dependent on the ion detection voltage to the output stage,wherein the second current is substantially equal to the first current.2. The conversion circuit according to claim 1 , wherein the second current is at least 90% of the first current claim 1 , preferably at least 95% of the first current claim 1 , more preferably at least 99% of the first current.3. The circuit according to claim 1 , wherein the second current is at most 110% of the first current claim 1 , preferably at most 105% of the first current claim 1 , more preferably at most 101% of the first current.4. The circuit according to claim 1 , wherein the supplementary stage comprises at least one current mirror for providing the second current.5. The circuit according to claim 4 , wherein the at least one current mirror comprises a complementary Darlington circuit.6. The circuit according to claim 4 , wherein the at least one current mirror is coupled with an input transistor for providing an input current to the current mirror claim 4 , the input current being dependent on the ion detection voltage.7. The circuit according to claim 1 , wherein the input stage comprises an input amplifier claim 1 , the input resistor being arranged in a feedback loop of the input amplifier.8. The circuit according to claim 7 , ...

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Номер записи: 57
12-05-2022 дата публикации

FOURIER TRANSFORM MASS SPECTROMETERS AND METHODS OF ANALYSIS USING THE SAME

Номер: US20220148873A1
Автор: Hager James W
Принадлежит:

Methods and systems for FTMS-based analysis having an improved duty cycle relative to conventional FTMS techniques are provided herein. In various aspects, the methods and systems described herein operate on a continuous ion beam, thereby eliminating the relatively long duration trapping and cooling steps associated with Penning traps or orbitraps of conventional FTMS systems, as well as provide increased resolving power by sequentially interrogating the continuous ion beam under different radially-confining field conditions. 1. A method of performing mass analysis , the method comprising:passing an ion beam comprising a plurality of ions through a quadrupole assembly having a quadrupole rod set extending from an input end for receiving the ions to an output end through which ions exit the quadrupole rod set,applying a first radial confinement signal to the quadrupole rod set so as to generate a first field for radially confining at least a first portion of the ions as they pass through the quadrupole rod set,before or after applying the first radial confinement signal, applying a second radial confinement signal to the quadrupole rod set so as to generate a second field for radially confining at least a second portion of the ions as they pass through the quadrupole rod set, wherein the second radial confinement signal comprises at least one of a different RF voltage and DC voltage to the rods of the quadrupole rod set relative to an RF voltage and a DC voltage of the first radial confinement signal,during the respective application of each of the first and second radial confinement signals, applying a voltage pulse across the quadrupole assembly so as to respectively excite radial oscillations of ions of the first and second portions at secular frequencies thereof, wherein fringing fields in proximity to said output end convert said radial oscillations into axial oscillations as said excited ions exit the quadrupole rod set,detecting said axially oscillating ions ...

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Номер записи: 58
12-05-2022 дата публикации

QUADRUPOLE DEVICES

Номер: US20220148874A1
Автор: Green Martin Raymond, Langridge David J.
Принадлежит: MICROMASS UK LIMITED

A method of operating a quadrupole device () is disclosed. The quadrupole device () is operated in a mode of operation by applying a repeating voltage waveform comprising a main drive voltage and at least one auxiliary drive voltage is applied to the quadrupole device to the quadrupole device (). The intensity of ions passing into the quadrupole device is varied with time in synchronisation with the repeating voltage waveform. This may be done such that the number of ions per unit phase which initially experience a phase within a first range of phases of the repeating voltage waveform is greater than the number of ions per unit phase which initially experience a phase within a second range of phases of the repeating voltage waveform. 1. A method of operating a quadrupole device , the method comprising:operating the quadrupole device in a mode of operation in which a repeating voltage waveform comprising a main drive voltage and at least one auxiliary drive voltage is applied to the quadrupole device;passing ions into the quadrupole device; andvarying the intensity of the ions passing into the quadrupole device in synchronisation with the repeating voltage waveform.2. The method of claim 1 , wherein the repeating voltage waveform repeats with a first period Θ claim 1 , and wherein varying the intensity of the ions passing into the quadrupole device comprises varying the intensity of the ions passing into the quadrupole device substantially periodically with a second period that is approximately equal to nΘ claim 1 , where n is a positive integer.3. The method of claim 1 , wherein the repeating voltage waveform repeats with a first period Θ claim 1 , the main drive voltage repeats with a third period T claim 1 , and wherein the first period Θ is greater than the third period T.4. The method of claim 1 , wherein varying the intensity of the ions passing into the quadrupole device comprises varying the intensity of the ions passing into the quadrupole such that the ...

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Номер записи: 59
28-03-2019 дата публикации

Ion profiling with a scanning quadrupole mass filter

Номер: US20190096654A1
Автор: Jason Lee Wildgoose, Keith Richardson, Martin Raymond Green
Принадлежит: Micromass UK Ltd

A mass spectrometer is disclosed comprising an ion mobility separation device for separating ions according to their ion mobility, a first quadrupole mass filter downstream of the ion mobility separation device, a control system arranged and adapted to scan and/or step the set mass of the first quadrupole mass filter a plurality of times over a first mass to charge ratio range of <±2 amu during the elution time of an ion mobility peak from the ion mobility separation device, and an analyser or ion detector downstream of the first quadrupole mass filter arranged and adapted to analyse or detect ions so as to acquire multi-dimensional ion mobility-mass to charge ratio data.

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Номер записи: 60
12-04-2018 дата публикации

Methods and Apparatus for Tandem Collision-Induced Dissociation Cells

Номер: US20180102239A1
Автор: OSER Harald, SCHOEN Alan E.
Принадлежит:

A mass spectrometer system comprises: (a) an ion source; (b) a mass filter; (c) a mass analyzer; (d) a partitioned ion fragmentation cell configured to receive ions from the mass filter and to outlet fragment ions to the mass analyzer comprising: (d1) a set of multipole rod electrodes; a housing enclosing the set of multipole rod electrodes and comprising an ion inlet and an ion outlet; (d2) a set of partitions within the housing separating the housing interior into a plurality of compartments; and (d3) a plurality of gas inlets, each gas inlet fluidically coupled to a source of a collision gas and to a respective compartment and having a respective inlet shutoff valve; and (e) a controller electrically coupled to each inlet shutoff valve and configured to independently control the pressure of collision gas within each compartment. 1. A mass spectrometer system comprising:an ion source configured to receive a sample from a sample inlet;a mass filter configured to receive the ions from the ion source;a mass analyzer including a detector configured to separate ions in accordance with their mass-to-charge ratios and detect the separated ions; a set of multipole rod electrodes;', 'a housing enclosing the set of multipole rod electrodes and comprising a housing interior, an ion inlet and an ion outlet;', 'a set of partitions within the housing separating the housing interior into a plurality of compartments, each partition comprising an aperture disposed along an ion pathway between the ion inlet and ion outlet; and', 'a plurality of gas inlets, each gas inlet fluidically coupled to a source of a collision gas and to a respective compartment and having a respective inlet shutoff valve;, 'a partitioned ion fragmentation cell configured to receive ions from the mass filter and to outlet fragment ions to the mass analyzer, the partitioned ion fragmentation cell comprisingat least one radio-frequency (RF) voltage source electrically coupled to the set of multipole rod ...

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Номер записи: 61
08-04-2021 дата публикации

Multiple beam secondary ion mass spectrometry device

Номер: US20210104394A1
Автор: David DOWSETT, Marina Verruno, Tom Wirtz
Принадлежит: Luxembourg Institute of Science and Technology LIST

A secondary ion mass spectrometer comprising a primary ion beam device, and means for collecting, mass filtering and subsequently detecting secondary ions released from a sample due to the sample having been impacted by a plurality of primary ion beams. The secondary ion mass spectrometer is remarkable in that it uses a plurality of primary ion beams in parallel for scanning the surface of the sample.

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Номер записи: 62
20-04-2017 дата публикации

Analysis of Complex Biological Matrices Through Targeting and Advanced Precursor and Product Ion Alignment

Номер: US20170108508A1
Автор: Brad J. WILLIAMS, James I. Langridge, Michael J. NOLD, Scott J. Geromanos, Steven J. Ciavarini
Принадлежит: Waters Technologies Corp

A method of mass spectrometry comprises ionising a sample eluting from a separation device in order to generate a plurality of parent ions. Multiple cycles of operation are performed as the sample elutes from the separation device. Each cycle of operation comprises mass analysing the parent ions to obtain parent ion mass spectral data, and mass analysing fragment or product ions derived from the parent ion to obtain fragment or product ion mass spectral data. Each cycle of operation also comprises mass analysing fragment or product ions derived from parent ions having mass to charge ratios within a first range to obtain first fragment or product ion mass spectral data, and mass analysing fragment or product ions derived from parent ions having mass to charge ratios within a second different range to obtain second fragment or product ion mass spectral data. The method can provide a hybrid data independent acquisition (DIA) and data dependent acquisition (DDA) approach.

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Номер записи: 63
11-04-2019 дата публикации

Ionizer and mass spectrometer system

Номер: US20190108991A1
Автор: Manabu Ueda, Wataru Fukui
Принадлежит: Shimadzu Corp

In the mass spectrometer system, a tip portion of a cylindrical portion ( 891 ) of a capillary ( 89 ) is coated with a coating material ( 892 ), the tip portion being an injection part for injecting a sample solution to an ionization section. Therefore, it is possible to suppress, by the coating material ( 892 ), the deformation of the capillary ( 89 ) when the sample solution is injected. In addition, it is possible to suppress the corrosion and the deformation of the capillary ( 89 ) by the coating material ( 892 ). As a result, the stability of the analysis operation in mass spectrometer system ( 1 ) can be improved.

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Номер записи: 64
28-04-2016 дата публикации

MASS SPECTROMETER

Номер: US20160118235A1
Автор: FUJITA Shinjiro
Принадлежит: SHIMADZU CORPORATION

In a pause time assigned for switching voltage applied to a quadrupole mass filter or other ion transport optical system so as to switch the mass-to-charge ratio of a target ion in an SIM measurement, the polarity of direct-current voltage applied to a pre-quadrupole mass filter is temporarily reversed. The voltage polarity reversal time is changed according to length of the pause time so that the ion intensity can sufficiently rise by the time the next dwell time begins. When the polarity of the voltage applied to the pre-quadrupole mass filter is reversed, the electric charges which lie on an insulating film of contaminants or other substances attached to the surface of the pre-quadrupole mass filter or on an insulating support structure are dispersed, whereby the charge-up is eliminated. Since ions are prevented from passing through, charge-up of a main quadrupole mass filter in the subsequent stage is also reduced. 1. A mass spectrometer having one or more ion transport optical systems for transporting ions by an effect of an electric field between an ion source and an ion detector , the mass spectrometer being capable of performing an SIM or MRM measurement in which an operation of sequentially performing a mass spectrometry on each of a plurality of ions having previously specified mass-to-charge ratios is cyclically performed , and the mass spectrometer comprising:a) a voltage generator for applying a direct-current voltage corresponding to the mass-to-charge of an ion to be monitored, to at least one of the ion transport optical systems in the SIM or MRM measurement; andb) a controller for controlling the voltage generator so that, in a pause time during which collection of detection data by the ion detector is suspended in conjunction with a switching of the mass-to-charge ratio of the ion to be monitored, if a polarity of the ion to be monitored in an SIM or MRM measurement is unchanged before and after the switching of the mass-to-charge ratio, then the ...

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Номер записи: 65
09-06-2022 дата публикации

DEVICE CONTROL TO MAXIMIZE SYSTEM UTILIZATION

Номер: US20220181131A1
Автор: Quarmby Scott T., SMITH Johnathan W.
Принадлежит: Thermo Finnigan LLC

A mass spectrometer includes an ion source configured to produce ions from a sample; a set of quadrupole rods configured to select ions based on a mass-to-charge ratio; a DC rod driver configured to produce a voltage; a DC rod driver filter configured to filter RF frequency interference; and a controller. The controller is configured to utilize the results of the constrained convex optimization to cause a DC rod drive to produce the DC filter input and provide a required voltage to the set of quadrupole rods, the constrained convex utilizing a impulse response curve of the DC rod driver filter to determine a DC filter input to achieve the required voltage on the set of quadrupole rods; select ions passing through the set of quadrupole rods based on the mass-to-charge ratio; and measure the intensity of the ions. 1. A method comprising:obtaining an impulse response curve for an electrical component;performing a constrained convex optimization using the impulse response curve to determine an DC filter input to achieve a required voltage on a set of quadrupole rods;utilizing the results of the constrained convex optimization to cause a DC rod driver to produce the DC filter input;selecting ions passing through the set of quadrupole rods based on the mass-to-charge ratio; andmeasuring the intensity of the ions.2. The method of wherein the electrical component is a DC filter.3. The method of wherein the impulse response curve is a theoretical impulse response curve determined by modeling a DC filter.4. The method of wherein the theoretical impulse response curve can be adjusted to account for ion signal response.5. The method of wherein the impulse response curve is an empirically determined impulse response curve.6. The method of wherein empirically determined impulse response curve is determined by monitoring the ion signal response.7. The method of wherein the empirically determined impulse response curve is measured for a similar electrical component on an exemplary ...

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Номер записи: 66
13-05-2021 дата публикации

METHODS AND APPARATUS FOR HIGH SPEED MASS SPECTROMETRY

Номер: US20210142993A1
Автор: Remes Philip M., SENKO Michael W.
Принадлежит:

A method of operating a mass spectrometer that allows for high-speed operation is disclosed. The method consists in separating the various steps needed to produce a mass spectrum into three or more conceptual stages in a pipeline, such that the instrument is performing steps to process more than two precursor-ion species simultaneously. In general, the number of stages in the pipeline should at least one more and, preferably, at least two more than the number of buffering storage devices in the instrument. The presently-taught methods and apparatus allow for nearly 100% duty cycle of ion accumulation for precursors of interest. 1. A mass spectrometry method , comprising:mass analyzing a first discrete batch of ions in a mass analyzer of a mass spectrometer system;storing a second discrete batch of ions within an ion storage device or a fragmentation cell of the mass spectrometer system, wherein the storage of the second discrete batch of ions is concurrent with at least a portion of the mass analyzing of the first discrete batch of ions; andpreparing an additional component of the mass spectrometer system to receive a third batch of ions from an ion source of the mass spectrometer system, wherein the preparing of the additional component is concurrent with at least a portion of the storage of the second discrete batch of ions within the ion storage device or fragmentation cell.2. A mass spectrometry method as recited in claim 1 , further comprising:transferring the second discrete batch of ions to the mass analyzer and mass analyzing the second discrete batch of ions therein; andintroducing the third batch of ions into the additional component of the mass spectrometer system, wherein the introducing of the third discrete batch of ions is concurrent with at least a portion of the mass analyzing the second discrete batch of ions.3. A mass spectrometry method claim 1 , comprising:(i) preparing a mass filtering device of a mass spectrometer system to transmit ...

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Номер записи: 67
13-05-2021 дата публикации

CURRENT DETECTION DEVICE AND SPECTROMETER USING THE SAME

Номер: US20210143000A1
Автор: HEGDE Anoop, Murthy Prakash Sreedhar, Pandurangan Anand, Selvaraj Siva
Принадлежит: ATONARP INC.

A device of detecting a current from a sensor is disclosed. The device includes an integrating circuit including a network of capacitors for providing a gain setting and configured to convert the current to a voltage ramp over a length of integration time, the integrating circuit further including a reset switch configured to connect an input and an output of the network of capacitors; an ADC configured to digitize the voltage ramp into a plurality of voltage samples; and a set of modules including an analyzing module configured to analyze the plurality of voltage samples to determine a slope of the voltage ramp; an outputting module configured to determine a magnitude of the current based on the slope of the voltage ramp and the gain setting; and a reconfiguring module that is configured to reconfigure the network of capacitors and reset the voltage ramp via the reset switch. 1. A device of detecting a current from a sensor , the device comprising:an integrating circuit including a network of capacitors for providing a gain setting and configured to convert the current to a voltage ramp over a length of integration time, the integrating circuit further including a reset switch configured to connect an input and an output of the network of capacitors when the reset switch is turned on;an analog-to-digital converter (ADC) configured to digitize the voltage ramp into a plurality of voltage samples;a set of modules including an analyzing module that is configured to analyze the plurality of voltage samples to determine a slope of the voltage ramp;an outputting module that is configured to determine a magnitude of the current based on the slope of the voltage ramp and the gain setting;a determining module that is configured to determine an out-of-range (OOR) state based on the voltage ramp; anda reconfiguring module that is configured to reconfigure the network of capacitors according to the OOR state and reset the voltage ramp via the reset switch.2. (canceled)3. The ...

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Номер записи: 68
04-05-2017 дата публикации

ACQUISITION OF FRAGMENT ION MASS SPECTRA OF IONS SEPARATED BY THEIR MOBILITY

Номер: US20170122906A1
Автор: LUBECK Markus, MANN Matthias, Park Melvin Andrew, Räther Oliver
Принадлежит:

The invention provides a method for acquiring fragment ion spectra of substances in complex substance mixtures wherein a trapped ion mobility spectrometer (“TIMS”) is used as the ion mobility separator separation device. The fragment ion spectra may be used for the identification of high numbers of proteins in complex mixtures, or for a safe quantification of some substances, by their fragment ion mass spectra in a mass spectrometer with up-front substance separator. TIMS with parallel accumulation provides the unique possibility to prolong the ion accumulation duration to find more detectable ion species without decreasing the measuring capacity for fragment ion mass spectra. The high measurement capacity for fragment ion mass spectra permits the repeated measurement of low abundance ion species to improve the quality of the fragment ion spectra. 1. A multi-cycle method to acquire fragment ion spectra of substances in complex substance mixtures by a mass spectrometer with an ion source , an ion mobility separator , a mass filter , an ion fragmentation cell , and a mass analyzer , wherein in a first measurement cycle a map of ion species with ion mobility scan times versus ion masses is measured , from which several sets of temporally separated ion species with distinct masses and distinct mobility scan times can be selected , and wherein in further measurement cycles the ion species of a set each are selected by their mobility scan time , filtered by mass in the mass filter , and fragmented in the fragmentation cell , and wherein the fragment ion mass spectra are measured by the mass analyzer , characterized by the fact that a trapped ion mobility spectrometer (TIMS) is used as ion mobility separator and that an RF quadrupole mass filter is used as the mass filter wherein the quadrupole mass filter is switched from the mass of a preceding ion species to the next ion species of a set in such a way that the mass of the next ion species is lower than the mass of the ...

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Номер записи: 69
04-05-2017 дата публикации

Controlling Gas-Phase Ion Interactions

Номер: US20170122907A1
Автор: Green Martin Raymond, Wildgoose Jason Lee
Принадлежит:

A mass spectrometer or ion mobility spectrometer is disclosed comprising: a first device for separating ions or molecules according to a physicochemical property; an ion mobility separation device for receiving and separating at least some of said ions or ions derived from said molecules according to their ion mobility; a gas supply connected to said ion mobility separation device for supplying gas into said ion mobility separation device; and a control system configured to adjust said gas supply so as to change the composition of gas within the ion mobility separation device as a function of time. 1. A mass spectrometer or ion mobility spectrometer comprising:a first device for separating ions or molecules according to a physicochemical property;an ion mobility separation or filter device for receiving and separating or filtering at least some of said ions, or ions derived from said molecules, according to their ion mobility;a gas supply connected to said ion mobility separation or filter device for supplying gas into said ion mobility separation or filter device; anda control system configured to adjust said gas supply so as to change the composition of gas within the ion mobility separation or filter device as a function of time.2. The method of claim 1 , wherein the ion mobility separation or filter device is configured to drive ions of different ion mobility from an entrance of the device towards an exit of the device at different rates so as to separate or filter ions according to their drift time along or through the device.3. A spectrometer as claimed in claim 1 , wherein the control system is configured to vary the gas composition in said ion mobility separation or filter device dynamically based on the separation or elution time in said first device.4. A spectrometer as claimed in claim 1 , wherein the gas composition in the ion mobility separation or filter device is controlled based on the ions or molecules eluting from the first device and passing into ...

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Номер записи: 70
04-05-2017 дата публикации

MASS SPECTROMETRY METHOD AND MASS SPECTROMETER

Номер: US20170125233A1
Автор: Mizutani Shiro, NAKANO Shigenobu
Принадлежит: SHIMADZU CORPORATION

The present invention is a mass spectrometer () for sequentially performing a measurement for a plurality of target ions, characterized by a storage section () for holding ion time-of-flight information concerning the time required for each of target ions to fly through each of the sections constituting the mass spectrometer, and a voltage controller () for changing, based on the ion time-of-flight information, the voltage applied to each of those sections to a voltage suited for each target ion, with a time lag corresponding to the difference in the timing of the arrival of the target ion at the section concerned. 1. A mass spectrometry method for sequentially performing a measurement for a plurality of target ions using a mass spectrometer , the method comprising:changing a voltage applied to each section constituting the mass spectrometer, from a voltage suited for the measurement of an ion subjected to the measurement before the target ion concerned, to a voltage suited for the measurement of the target ion concerned, at a timing corresponding to a time required for each of the target ions to fly through that section.2. The mass spectrometry method according to claim 1 , wherein the time of flight is associated with a mass-to-charge ratio of an ion.3. The mass spectrometry method according to claim 1 , wherein at least one kind of positive ion and at least one kind of negative ion are included in the plurality of target ions.4. A mass spectrometer for sequentially performing a measurement for a plurality of target ions claim 1 , comprising:a) a voltage output section for generating a voltage for each section constituting the mass spectrometer; andb) a controller for controlling the voltage output section so as to change the voltage applied to each section constituting the mass spectrometer, from a voltage suited for the measurement of an ion subjected to the measurement before the target ion concerned, to a voltage suited for the measurement of the target ion ...

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Номер записи: 71
04-05-2017 дата публикации

SPATIAL ZOOM MODE FOR ACCUMULATIVE TRAPPED ION MOBILITY SPECTROMETRY

Номер: US20170125234A1
Автор: Park Melvin Andrew, Räther Oliver
Принадлежит:

The invention relates to the operation of ion mobility spectrometers based on gases pushing the ions over electrical field barriers, preferably in combination with mass spectrometers, and relates to trapped ion mobility spectrometers (“TIMS”). The invention proposes to accumulate and to scan the ions of a selected range of mobilities by using a long and flat electric field ramp created by additional voltages. By a voltage supplied at the beginning of the flat ramp, the lowest mobility of the mobility range of ions to be collected can be selected. By the difference of the voltages at the beginning and the end, the width of the mobility range is determined. The spatial zoom advantageously can collect considerable more ions of interest than a temporal zoom without severe losses by space charge effects, and more ions can be detected in the mass-mobility map. 1. A method for analyzing ions of a selected range of mobilities using a trapped ion mobility separator comprising an accumulation unit and a scan unit , comprising the steps of:(a) collecting ions over a range of mobilities in the accumulation unit;(b) transferring ions from the accumulation unit into the scan unit wherein a voltage of the scan unit is adjusted such that transferred ions having a mobility lower than a first value are not stored in the scan unit and transferred ions having a mobility higher than the predetermined value are stored in the scan unit; and(c) separating the stored ions of the selected mobility range according to mobility by scanning a voltage of the scan unit.2. The method according to claim 1 , wherein claim 1 , in the step (b) claim 1 , a voltage of the accumulation unit is adjusted such that ions which are collected in the accumulation unit and have a mobility higher than a second value claim 1 , said second value being higher than the first value claim 1 , remain stored in the accumulation unit claim 1 , and wherein the remaining ions are neutralized or ejected from the accumulation ...

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Номер записи: 72
04-05-2017 дата публикации

Ion Profiling with a Scanning Quadrupole Mass Filter

Номер: US20170125235A1
Автор: Green Martin Raymond, Richardson Keith, Wildgoose Jason Lee
Принадлежит:

A mass spectrometer is disclosed comprising an ion mobility separation device for separating ions according to their ion mobility, a first quadrupole mass filter downstream of the ion mobility separation device, a control system arranged and adapted to scan and/or step the set mass of the first quadrupole mass filter a plurality of times over a first mass to charge ratio range of <±2 amu during the elution time of an ion mobility peak from the ion mobility separation device, and an analyser or ion detector downstream of the first quadrupole mass filter arranged and adapted to analyse or detect ions so as to acquire multi-dimensional ion mobility-mass to charge ratio data. 1. A mass spectrometer comprising:an ion mobility separation device for separating ions according to their ion mobility;a first quadrupole mass filter arranged downstream of said ion mobility separation device;a control system arranged and adapted to scan and/or step the set mass of said first quadrupole mass filter a plurality of times over a first mass to charge ratio range of <±2 amu during the elution time of an ion mobility peak from said ion mobility separation device; andan analyser or ion detector arranged downstream of said first quadrupole mass filter, wherein said analyser or ion detector is arranged and adapted to analyse or detect ions so as to acquire multi-dimensional ion mobility-mass to charge ratio data.2. A mass spectrometer as claimed in claim 1 , wherein said first mass to charge ratio range is centred at the mass to charge ratio of a target ion of interest.34-. (canceled)5. A mass spectrometer as claimed in claim 1 , further comprising a fragmentation claim 1 , collision or reaction device for fragmenting or reacting ions so as to produce fragment or product ions;wherein said fragmentation, collision or reaction device is arranged downstream of said ion mobility separation device and upstream of said analyser or ion detector.67-. (canceled)8. A mass spectrometer as claimed in ...

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Номер записи: 73
16-04-2020 дата публикации

MASS ANALYSIS APPARATUS AND METHOD

Номер: US20200118804A1
Автор: MATOBA Yoshiki, OKAWA Shin, SAKUTA Masahiro
Принадлежит:

Disclosed is a mass analysis apparatus and method, wherein the precision of detection of a first material including a second material is improved, without enlarging the apparatus, and the measurement time is reduced. The mass analysis apparatus for analyzing a sample containing a first material including an organic compound and at least one second material including an organic compound and having a mass spectrum peak overlapping that of the first material includes a peak correction unit, wherein, when an intensity ratio (peak B)/(peak A) of peak A, not overlapping that of the first material, and peak B, overlapping that of the first material, is a correction coefficient (W), an intensity of a net peak D of the mass spectrum of the first material is calculated by subtracting W×(intensity of peak A) from an intensity of a peak C of the mass spectrum of the first material in the sample. 1. A mass analysis apparatus for analyzing a sample containing a first material comprising an organic compound and at least one second material comprising an organic compound and having a mass spectrum peak overlapping a mass spectrum peak of the first material , the mass analysis apparatus comprising:an ion source for ionizing the first material and the second material, a detector for detecting a mass spectrum peak of a gas component which is ionized in the ion source and a computer configured to calculate a net peak of the mass spectrum based on a detection signal from the detector,wherein the computer comprises a peak correction unit in communication with a memory unit storing computer readable instructions that are executed by a processor, the peak correction unit configured such that, when an intensity ratio (peak B)/(peak A) of peak A, which does not overlap the mass spectrum peak of the first material, and peak B, which overlaps the mass spectrum peak of the first material, among mass spectrum peaks of standard materials for the at least one second material, is a correction ...

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Номер записи: 74
01-09-2022 дата публикации

Current detection device and spectrometer using the same

Номер: US20220277950A1
Автор: Anand Pandurangan, Anoop Hegde, Prakash Sreedhar Murthy, Siva Selvaraj
Принадлежит: Atonarp Inc

A device of detecting a current from a sensor is disclosed. The device includes an integrating circuit including a network of capacitors for providing a gain setting and configured to convert the current to a voltage ramp over a length of integration time, the integrating circuit further including a reset switch configured to connect an input and an output of the network of capacitors; an ADC configured to digitize the voltage ramp into a plurality of voltage samples; and a set of modules including an analyzing module configured to analyze the plurality of voltage samples to determine a slope of the voltage ramp; an outputting module configured to determine a magnitude of the current based on the slope of the voltage ramp and the gain setting; and a reconfiguring module that is configured to reconfigure the network of capacitors and reset the voltage ramp via the reset switch.

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Номер записи: 75
23-04-2020 дата публикации

QUADRUPOLE MASS SPECTROMETER

Номер: US20200126780A1
Автор: SHIMOMURA Manabu
Принадлежит: SHIMADZU CORPORATION

Measurement of a standard sample is repeated under control of an analysis control unit () while a CD voltage applied to a conversion dynode () of a detection unit () is gradually changed by a CD voltage adjustment unit (). Then, every time a measured mass spectrum is obtained, a spectrum pattern determination unit () determines whether a pattern of the measured mass spectrum matches a pattern of a standard mass spectrum of a standard sample in a compound database (), and determines the CD voltage at the time of being regarded as matching to be the set value. When the pattern of the mass spectrum is adjusted by changing the voltage applied to the ion lens (), performance such as sensitivity is likely to be unstable due to stain on the lens electrode or the like, but since the detection unit () is unlikely to be affected by such a stain, unstable performance can be avoided. 1. A quadrupole mass spectrometer using a quadrupole mass filter as a mass separation unit configured to separate ions to be measured according to a mass-to-charge ratio , the quadrupole mass spectrometer comprising:a) a detection unit configured to detect ions having passed through the quadrupole mass filter;b) a voltage adjustment unit configured to adjust any one ofa voltage that determines a gain in the detection unit, anda voltage to be applied to an electrode configured to form an electric field in a path of ions having passed through the quadrupole mass filter to the detection unit; andc) a control unit configured to adjust a voltage with the voltage adjustment unit so that at least a part of a spectrum pattern in a measured mass spectrum obtained by measurement in the quadrupole mass spectrometer of a predetermined sample matches or approaches a corresponding spectrum pattern in a target mass spectrum.2. The quadrupole mass spectrometer according to claim 1 , whereinthe detection unit includes a conversion dynode and a secondary electron multiplier, andthe voltage adjustment unit is also ...

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Номер записи: 76
03-06-2021 дата публикации

QUADRUPOLE MASS SPECTROMETER, QUADRUPOLE MASS SPECTROMETRY METHOD, AND PROGRAM STORAGE MEDIUM STORING PROGRAM FOR QUADRUPOLE MASS SPECTROMETER

Номер: US20210166932A1
Автор: Ikeyama Toshihiro, INOUE Takahito, Sasai Kohei, SASAKURA Kazushi, UCHIHARA Hiroshi
Принадлежит:

A quadrupole mass spectrometer includes an ion source that ionizes a sample, a filter unit that includes a quadrupole and separates ions generated from the ion source according to mass, a detector that detects ions passing through the filter unit, a filter voltage controller that controls a filter voltage applied to the quadrupole to switch between a blocking mode in which ions entering the filter unit are not allowed to impinge on the detector and a passing mode in which ions entering the filter unit are allowed to impinge on the detector, the filter voltage including a radio-frequency voltage and a direct-current voltage, a baseline computing unit that computes a baseline based on outputs of the detector in the blocking mode, and an analyzing unit that outputs an analysis result of the sample based on outputs of the detector in the passing mode and the computed baseline. 1. A quadrupole mass spectrometer comprising:an ion source configured to ionize a sample;a filter unit including a quadrupole, the filter unit being configured to separate ions generated from the ion source according to mass;a detector configured to detect ions passing through the filter unit;a filter voltage controller configured to control a filter voltage applied to the quadrupole to switch between a blocking mode in which ions entering the filter unit are not allowed to impinge on the detector and a passing mode in which ions entering the filter unit are allowed to impinge on the detector, the filter voltage comprising a radio-frequency (RF) voltage and a direct-current (DC) voltage;a baseline computing unit configured to compute a baseline based on outputs of the detector in the blocking mode; andan analyzing unit configured to output an analysis result of the sample based on outputs of the detector in the passing mode and the baseline computed by the baseline computing unit.2. The quadrupole mass spectrometer according to claim 1 ,wherein the filter voltage controller sweeps the filter ...

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Номер записи: 77
28-05-2015 дата публикации

Exponential Scan Mode for Quadrupole Mass Spectrometers to Generate Super-Resolved Mass Spectra

Номер: US20150144784A1
Автор: GROTHE, JR. Robert A.
Принадлежит:

A novel scanning method of a mass spectrometer apparatus is introduced so as to relate by simple time shifts, rather than time dilations, the component signal (“peak”) from each ion even to an arbitrary reference signal produced by a desired homogeneous population of ions. Such a method and system, as introduced herein, is enabled in a novel fashion by scanning exponentially the RF and DC voltages on a quadrupole mass filter versus time while maintaining the RF and DC in constant proportion to each other. In such a novel mode of operation, ion intensity as a function of time is the convolution of a fixed peak shape response with the underlying (unknown) distribution of discrete mass-to-charge ratios (mass spectrum). As a result, the mass distribution can be reconstructed by deconvolution, producing a mass spectrum with enhanced sensitivity and mass resolving power. 1. A mass spectrometer , comprising:a quadrupole mass filter for mass selectively transmitting ions from an entrance end to an exit end, the quadrupole mass filter including:four elongated electrodes arranged in parallel; anda power supply, coupled to the electrodes, for applying a resolving DC voltage U and an RF voltage of amplitude V to the electrodes, the power supply being operated to temporally vary U and V during a scan period such that U and V both increase exponentially with time while the ratio of U to V is maintained constant; anda detector, positioned to receive ions transmitted to the exit end of the quadrupole mass filter, for sensing ions and responsively generating a signal representative of the abundance of sensed ions.2. The mass spectrometer of claim 1 , wherein the detector is an arrayed detector configured to measure the spatial distribution of ions within a detection plane.3. The mass spectrometer of claim 1 , wherein the power supply is operated to cause multiple ion species having a range of mass-to-charge ratios within a transmission window to be transmitted to the exit end of the ...

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Номер записи: 78
18-05-2017 дата публикации

MS/MS MASS SPECTROMETRIC METHOD AND MS/MS MASS SPECTROMETER

Номер: US20170140909A1
Автор: UMEMURA Yoshikatsu
Принадлежит: SHIMADZU CORPORATION

When, in performing MS/MS analysis on a multivalent ion originated from a target component, an analyzing operator inputs at least two values of a mass value mof an eliminated fragment, a valence zof the eliminated fragment, a valence zof a precursor ion and a valence zof a product ion by an inputting unit, a valence calculating unit calculates an uninput valence zor zbased on the relation, z=z+z. Upon the start of the MS/MS analysis, a precursor ion m/z setting unit sets m/z=Mof an ion that passes through a front-stage quadrupole mass filter , and a passed product ion m/z calculating unit calculates m/z=Mof the product ion that passes through a rear-stage quadrupole mass filter by applying M, m, zand zabove to the relational expression, M=(M×z−m)/z. 1. An MS/MS mass spectrometer including an ionizing unit for ionizing a target component in a sample , a first mass separating unit for selecting , as a precursor ion , an ion having a specific mass-to-charge ratio from multivalent ions , the multivalent ion having a valence of two or more out of ions originated from the target component , a dissociation operation unit for dissociating the precursor ion selected by the first mass separating unit , a second mass separating unit for selecting a product ion having a specific mass-to-charge ratio from product ions generated through the dissociation , and a detecting unit for detecting the ion selected by the second mass separating unit , the MS/MS mass spectrometer comprising:{'sub': 'Loss', 'a) a first inputting unit for allowing a user to input and set a mass mof a fragment eliminated from the precursor ion through the dissociation;'}{'sub': Loss', 'Prec', 'Prod', 'Loss, 'b) a second inputting unit for allowing the user to input and set at least two of three parameters of a valence zof the fragment, a valence Zof the precursor ion and a valence zof the product ion, the valence zof the fragment being a valence of the fragment eliminated from the precursor ion through the ...

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Номер записи: 79
18-05-2017 дата публикации

ADDITION OF REACTIVE SPECIES TO ICP SOURCE IN A MASS SPECTROMETER

Номер: US20170140914A1
Автор: WEHRS Henning
Принадлежит:

Disclosed is a method of inductively coupled plasma mass spectrometry (ICP-MS), comprising steps of introducing at least one sample comprising at least one sample species, and at least one reactive species, into an inductively coupled plasma source, such that at least one molecular adduct ion of the at least one reactive species and the at least one sample species is formed; transferring the at least one molecular adduct ion into a collision cell that is arranged between the inductively coupled plasma source and at least one mass analyzer, transferring the at least one molecular adduct ion, or a product thereof, into the at least one mass analyzer, and analyzing the mass of the at least one molecular adduct ion, or the product thereof, in the at least one mass analyzer. Also disclosed is a mass spectrometer that is adapted to perform the method. 1. A method of inductively coupled plasma mass spectrometry (ICP-MS) , comprising:a. providing at least one inductively coupled plasma source;b. introducing at least one sample comprising at least one sample species, and at least one reactive species, into the plasma source, such that at least one molecular adduct ion of the at least one reactive species and the at least one sample species is formed;c. transferring the at least one molecular adduct ion into a collision cell that is arranged between the inductively coupled plasma source and at least one mass analyzer,d. transferring the at least one molecular adduct ion, or a product thereof, into the at least one mass analyzer, ande. analyzing the mass of the at least one molecular adduct ion, or the product thereof, in the at least one mass analyzer.2. The method of claim 1 , wherein the product is a fragment ion or a further molecular adduct ion.3. The method of claim 1 , wherein at least one interfering sample ion having the same mass as the molecular adduction ion is formed in the inductively coupled plasma source claim 1 , and wherein the method further comprises ...

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Номер записи: 80
14-08-2014 дата публикации

Method of Operating a Mass Filter in Mass Spectrometry

Номер: US20140224975A1
Автор: Andreas Kuehn, Dirk Nolting, Eugen Damoc, Jan-Peter Hauschild, Oliver Lange
Принадлежит: Thermo Fisher Scientific Bremen GmbH

Disclosed herein is a mass spectrometry method having steps of: transmitting ions from an ion source through a mass filter; processing ions received from the mass filter in a discontinuous ion optical device downstream of the mass filter; operating the mass filter for a plurality of periods in a mass/charge ratio (m/z) filtering mode to transmit ions in one or more selected ranges of m/z to the discontinuous ion optical device; and operating the mass filter in a broad mass range mode transmitting ions of a mass range substantially wider than any mass range transmitted in the m/z filtering mode during one or more periods in which the discontinuous ion optical device is not processing ions from the mass filter. Utilization of this method assists to reduce contamination in the mass filter.

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Номер записи: 81
14-08-2014 дата публикации

Quadrupole Mass Spectrometer with Enhanced Sensitivity and Mass Resolving Power

Номер: US20140224980A1
Автор: GROTHE, JR. Robert A., SCHOEN Alan E.
Принадлежит: Thermo Finnigan LLC

A novel method and mass spectrometer apparatus is introduced to spatially and temporally resolve images of one or more ion exit patterns of a multipole instrument. In particular, the methods and structures of the present invention measures the ion current as a function of time and spatial displacement in the beam cross-section of a quadrupole mass filter via an arrayed detector. The linearity of the detected quadrupole ion current in combination with it reproducible spatial-temporal structure enables the deconvolution of the contributions of signals from individual ion species in complex mixtures where both sensitivity and mass resolving power are essential. 1. A method of analyzing a sample by mass spectrometry , comprising the steps of:generating a stream of ions from the sample;delivering the ions to the inlet end of a multipole, the multipole defining a central longitudinal axis and first and second transverse axes;generating an electric field within the multipole, the electric field causing a subset of ions having a range of mass-to-charge values (m/z's) to be selectively transmitted to a distal end of the multipole along the central longitudinal axis, the range of m/z's of the transmitted ions being determined by at least one parameter of the electric field;progressively varying the at least one parameter of the electric field;acquiring a series of temporally-resolved ion images of ions selectively transmitted to the distal end of the multipole while the at least one parameter of the electric field is varied, each ion image containing information regarding the intensities of ions sensed at different locations on at least one transverse axis; anddeconvolving data in the series of ion images to produce a mass spectrum.2. The method of claim 1 , wherein the multipole is a quadrupole.3. The method of claim 2 , wherein the step of generating the electric field comprises applying oscillatory and direct current (DC) voltages to electrodes of the quadrupole claim 2 , ...

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Номер записи: 82
10-06-2021 дата публикации

ACQUISITION STRATEGY FOR OBTAINING ELECTRON-IONIZATION-LIKE SPECTRA

Номер: US20210175059A1
Автор: Campbell John Lawrence
Принадлежит:

In one aspect, a method of performing mass spectrometry is disclosed, which comprises forming at least two adduct ions of a molecular species in a sample, wherein said adduct ions comprise at least two different isotopes (e.g., the naturally occurring isotopes) of any of sodium and potassium, subjecting the adduct ions to Electron Impact Excitation of Ions from Organics (EIEIO) fragmentation to generate a plurality of fragment product ions, and using a mass analyzer to generate a mass spectrum of said product ions. The mass spectrum of the product ions can be analyzed to identify the parent ion. By way of example, the analysis of the mass spectrum can involve utilizing a reference library that contains mass spectral information regarding electron induced ionization of a plurality of reference compounds. 1. A method of performing mass spectrometry , comprising:forming at least two adduct ions of a molecular species in a sample, wherein said adduct ions comprise at least two different isotopes of any of sodium and potassium,subjecting said adduct ions to Electron Impact Excitation of Ions from Organics (EIEIO) fragmentation to generate a plurality of fragment product ions, andusing a mass analyzer to generate a mass spectrum of said productions.2. The method of claim 1 , wherein said potassium isotopes comprise K and K.3. The method of claim 1 , wherein said sodium isotopes comprise Na and Na.4. The method of claim 1 , wherein said step of forming at least two adduct ions comprisesadding any of potassium and sodium salt comprising at least two isotopic forms of sodium or potassium to a sample suspected of containing said molecular species so as to generate an adduct molecular species, andionizing said adduct molecular species to form said adduct ions.5. The method of claim 1 , further comprising analyzing said mass spectrum so as to identify said molecular species associated with said adduct ions.6. The method of claim 5 , wherein said step of analyzing said mass ...

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Номер записи: 83
10-06-2021 дата публикации

MASS SPECTROMETER

Номер: US20210175066A1
Автор: NAGASAO Kota, UEDA Manabu
Принадлежит: SHIMADZU CORPORATION

Four rod electrodes (to ) for separating ions according to a mass-to-charge ratio are held by a rod holder (). The rod holder () is placed on a metal holder sustaining stand () provided on a bottom surface of a vacuum housing (), and is fixed while being pressed by a fixation band () fixed to the holder sustaining stand () with screws (). The fixation band () is made from phosphor bronze having higher thermal conductivity than thermal conductivity of stainless steel or the like. Therefore, heat generated in the rod holder () due to dielectric loss is not only directly transmitted to the holder sustaining stand (), but also efficiently transmitted to the holder sustaining stand () through the fixation band (). With this, the heat of the rod holder () is efficiently dissipated, and non-uniformity of temperature of the rod holder can be reduced. 1. A mass spectrometer including an ion optical element including a plurality of rod electrodes arranged around a linear axis , the ion optical element being configured to separate ions derived from a sample component introduced into a space surrounded by the plurality of rod electrodes according to a mass-to-charge ratio using an electric field formed by a voltage including a radio frequency voltage applied to the rod electrodes , the mass spectrometer comprising:a) a boundary member configured to define a region in which the ion optical element is arranged;b) a rod holder made from an insulating material and configured to hold the plurality of rod electrodes;c) a holder sustaining stand which is fixed to the boundary member and on which the rod holder is placed; andd) a fixation band made of a thin plate and attached to the holder sustaining stand while both ends are fixed to the holder sustaining stand, and a portion between the both ends are pressed to the holder sustaining stand with the rod holder secured between the portion and the holder sustaining stand, whereinthe fixation band is made from phosphor bronze.2. A mass ...

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Номер записи: 84
24-05-2018 дата публикации

Capacitors and radio frequency generators and other devices using them

Номер: US20180144922A1
Автор: Chui Ha Cindy WONG, Tak Shun Cheung
Принадлежит: PerkinElmer Health Sciences Canada Inc

Certain configurations of a stable capacitor are described which comprise electrodes produced from materials comprising a selected coefficient of thermal expansion to enhance stability. The electrodes can be spaced from each other through one of more dielectric layers or portions thereof. In some instances, the electrodes comprise integral materials and do not include any thin films. The capacitors can be used, for example, in feedback circuits, radio frequency generators and other devices used with mass filters and/or mass spectrometry devices.

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Номер записи: 85
31-05-2018 дата публикации

A detection method for low molecular weight heparin complete degradation products using hydrophilic interaction chromatography and multiple reaction monitoring tandem mass spectrometry

Номер: US20180149626A1
Автор: Chi Lianli, Liu Xinyue, SHENG Anran, SUN Xiaojun
Принадлежит:

A detection method for low molecular weight heparin complete degradation products using hydrophilic interaction chromatography and multiple reaction monitoring tandem mass spectrometry. Identifying the original reducing end and non-reducing end of enoxaparin sodium by means of reducing the reducing end of enoxaparin sodium, and performing hydrolysis using hydrogen peroxide. Performing quantitative analysis on all component units utilizing hydrophilic interaction chromatography and multiple reaction monitoring tandem mass spectrometry, in particular quantifying low-content special structures and characterizing low molecular weight heparin. 1. A method for testing completely degraded products from low-molecular-weight heparins using a hydrophilic interaction chromatography combined a multiple reaction monitoring mass spectrometry , comprising:(1) dissolving ammonium acetate in deionized water up to 3 to 10 mM as mobile phase A (MPA);(2) dissolving ammonium acetate in deionized water and adding acetonitrile resulted in mobile phase B (MPB) wherein concentration of ammonium acetate is between 3 and 10 mM and acetonitrile is 90 to 98% by volume;(3) reducing 10 to 50 μg of hydrolyzate products, which contains internal standard, of the low-molecular-weight heparins by sodium borohydride for 10 to 12 hours, and hydrolyzing by hydrogen peroxide, then preparing the degraded products from the low-molecular-weight heparins at the concentration between 1 and 10 μg/μL as a test solution for step (4), if end structures of the low-molecular-weight heparins are desired for further identification;or preparing the hydrolyzate products, which contains the internal standard, at the concentration between 1 and 10 μg/μL as the test solution for step (4) if the end structures of the low-molecular-weight heparins are not desired for further identification;(4) centrifuging the test solution obtained from step (3), loading the supernatant onto a hydrophilic interaction chromatography column ...

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Номер записи: 86
11-06-2015 дата публикации

AUTOMATIC AMINO ACID SEQUENCING OF GLYCOPEPTIDE BY Y1 IONS

Номер: US20150160232A1
Автор: CHEN Chein-Hung, CHEN Chung-Hsuan, Hsieh Hsin Yu, HSU Pang-Hung, LIN Jung-Lee
Принадлежит:

Apparatus and methods for automatic amino acid sequencing of a glycopeptide by mass spectrometry. The glycopeptide is fragmented by higher energy collision dissociation fragmentation, and sequentially fragmented by collision induced dissociation fragmentation. The glycopeptide Y1 ion is isolated, and the mass spectra of fragmented glycopeptide Y1 ions provide mass spectral peaks corresponding to the amino acid sequence of the glycopeptide. 2. The mass spectrometer apparatus of claim 1 , wherein the higher energy collision dissociation fragmentation has a normalized collision energy from 70% to 110% claim 1 , based on 100 V kinetic energy as being 100% high collision energy for an m/z of 2000.3. The mass spectrometer apparatus of claim 1 , wherein the ion source includes MALDI and ESI sources.4. The mass spectrometer apparatus of claim 1 , wherein the ion source includes an ESI source with a pulsed beam.5. The mass spectrometer apparatus of claim 1 , including an ion guide between the ion source and the quadrupole ion trap.6. The mass spectrometer apparatus of claim 1 , wherein the quadrupole ion trap is a mass analyzer.7. The mass spectrometer apparatus of claim 1 , wherein the linear ion trap is a mass analyzer.8. A method for automatic amino acid sequencing of a glycopeptide claim 1 , the method comprising:obtaining the full mass range mass spectrum of glycopeptide analyte ions in a quadrupole ion trap;selecting target glycopeptide ions from the full mass range mass spectrum and isolating the target glycopeptide ions in the quadrupole ion trap;fragmenting the target glycopeptide ions by higher energy collision dissociation fragmentation, thereby obtaining fragmented glycopeptide analyte ions and glycopeptide Y1 ions;obtaining the mass spectrum of the fragmented glycopeptide analyte ions and glycopeptide Y1 ions in the linear quadrupole ion trap, thereby identifying the glycopeptide Y1 ions;isolating the glycopeptide Y1 ions in the linear ion trap;fragmenting the ...

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Номер записи: 87
15-09-2022 дата публикации

MASS SPECTROMETER

Номер: US20220293408A1
Автор: NISHIGUCHI Masaru
Принадлежит: SHIMADZU CORPORATION

An ion guide () provided in a first intermediate vacuum chamber includes six rod electrodes ( to ) and a voltage generation unit. The six rod electrodes ( to ) are in a hexapole arrangement on the ion incident side, and the two rod electrodes ( and ) are tilted with respect to the Z-axis in a manner approaching a central axis () as they progress in the ion transport direction, so that the four rod electrodes (, and ) are in a quadrupole arrangement. The voltage generation unit applies radio-frequency voltages ±Vcosωt whose phases are inverted to each other between adjacent rod electrodes of the six rod electrodes ( to ) around the central axis (), applies a DC voltage U to the four electrodes (, and ) by which ions pass through them in an excellent manner, and applies a DC voltage U different from U to the other two rod electrodes ( and ). 1. A mass spectrometer comprising:an ion transport optical system configured to transport an ion to be analyzed, whereinthe ion transport optical system includesN rod electrodes, N being an even number of six or more, arranged to extend in an ion transport direction as a whole, anda voltage generation unit configured to apply predetermined voltages to the N rod electrodes respectively,the N rod electrodes are in an N-pole arrangement on an ion incident side, and, in order that four rod electrodes among the N rod electrodes are in a quadrupole arrangement on an ion emission side, at least two rod electrodes of the four rod electrodes are tilted with respect to a central axis of the N-pole arrangement or the quadrupole arrangement so as to approach the central axis along the ion transport direction, andthe voltage generation unit is configured to be able to apply radio-frequency voltages having phases inverted between adjacent rod electrodes of the N rod electrodes around an ion optical axis, to be able to apply a first DC voltage to the four rod electrodes in a quadrupole arrangement on the ion emission side, and to be able to ...

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Номер записи: 88
15-09-2022 дата публикации

Improved Electrode Arrangement

Номер: US20220293409A1
Автор: Balschun Wilko, Chernyshev Denis, Denisov Eduard V., HAUSCHILD Jan-Peter, MAKAROV Alexander A.
Принадлежит:

The present invention provides an electrode arrangement for an ion trap, ion filter, an ion guide, a reaction cell or an ion analyser. The electrode arrangement comprises an RF electrode ′ mechanically coupled to a dielectric material The RF electrode ′, ′ is mechanically coupled to the dielectric material by a plurality of separators that are spaced apart and configured to define a gap between the RF electrode ′ and the dielectric material Each of the plurality of separators comprises a projecting portion and the dielectric material comprises corresponding receiving portions such that on coupling of the RF electrode ′ to the dielectric material the projecting portion of each separator is received within the corresponding receiving portion a of the dielectric material The present invention also relates to an ion trap comprises the electrode arrangement and a method of manufacturing the electrode arrangement 1. An electrode arrangement for an ion trap , ion filter , an ion guide , a reaction cell or an ion analyser , the electrode arrangement comprising:an RF electrode mechanically coupled to a dielectric material; andat least one DC electrode located between the dielectric material and the RF electrode;wherein the RF electrode is mechanically coupled to the dielectric material by a plurality of separators that are spaced apart and configured to define a gap between the RF electrode and the dielectric material and wherein each of the plurality of separators comprises a projecting portion and the dielectric material comprises corresponding receiving portions such that on coupling of the RF electrode to the dielectric material, the projecting portion of each separator is received within the corresponding receiving portion of the dielectric material;wherein the RF electrode has a surface opposing the dielectric material;wherein the DC electrode extends across the dielectric material such that at least a part of the DC electrode lies directly between the surface of the ...

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Номер записи: 89
15-09-2022 дата публикации

ION GUIDE

Номер: US20220293410A1
Автор: MAKAROV Alexander A., STEWART Hamish, Wagner Alexander
Принадлежит:

An ion guide may comprise a set of plate electrodes, each plate electrode having a plurality of apertures formed therethrough. The set of plate electrodes are spatially arranged such that a relative positioning of each plurality of apertures of a respective plate electrode of the set of plate electrodes and respective adjacent plate electrodes of the set of plate electrodes defines a continuous ion flight path through the respective plurality of apertures of each plate electrode of the set of plate electrodes. The continuous ion flight path has a helical-based and/or spiral-based shape. 1. An ion guide , comprising:a first plurality of electrode arrangements, each electrode arrangement comprising respective parallel bar electrodes, with a respective gap therebetween; anda second plurality of electrode arrangements, each electrode arrangement comprising respective parallel electrode parts, with a respective gap therebetween, the parallel electrode parts of the second plurality of electrode arrangements being arranged orthogonally with respect to the parallel bar electrodes of the first plurality of electrode arrangements, such that the respective gaps of the first plurality of electrode arrangements are aligned with the respective gaps of the second plurality of electrode arrangements to allow ions to travel therethrough along a continuous path;wherein the first and second pluralities of electrode arrangements are arranged alternately along the continuous path; andwherein each of the first plurality of electrode arrangements is provided with an RF potential and each of the second plurality of electrode arrangements is provided only with one or more DC potentials or wherein each of the first plurality of electrode arrangements is provided with only one or more DC potentials and each of the second plurality of electrode arrangements is provided with an RF potential.2. The ion guide of claim 1 , wherein each electrode arrangement of the second plurality of electrode ...

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Номер записи: 90
07-05-2020 дата публикации

INDUCTIVELY COUPLED PLASMA MASS SPECTROMETER WITH MASS CORRECTION

Номер: US20200144046A1
Автор: Kelinske Mark Lee, Liba Amir, SUGIYAMA Naoki, Woods Glenn David
Принадлежит: AGILENT TECHNOLOGIES, INC.

Systems and methods for controlling mass filtering of polyatomic ions in an ion beam passing through an inductively coupled plasma mass spectrometer (ICP-MS). Polyatomic ion mass data representative of the exact mass of a polyatomic ion having a target isotope is determined. A control signal is generated based on the determined polyatomic ion mass data and output to an ICP-MS to filter based on mass the polyatomic ions in the ion beam traveling through the ICP-MS to an ion detector. 1. A method for controlling mass filtering of polyatomic ions in an ion beam passing through an inductively coupled plasma mass spectrometer (ICP-MS) comprising:determining polyatomic ion mass data representative of the exact mass of a polyatomic ion having a target isotope;generating a first control signal based on the determined polyatomic ion mass data; andoutputting the first control signal to an ICP-MS to filter based on mass the polyatomic ions in the ion beam traveling through the ICP-MS to an ion detector.2. The method of claim 1 , wherein the polyatomic ion mass data comprises the exact mass of the polyatomic ion having the target isotope.3. The method of claim 2 , further comprising storing mass data in memory including storing the polyatomic ion mass data.4. The method of claim 3 , wherein the determining comprises accessing the polyatomic ion mass data stored in memory.5. The method of claim 2 , wherein the determining comprises calculating the exact mass of the polyatomic ion having the target isotope.6. The method of claim 2 , wherein the determining comprises performing a table look up to determine the exact mass of the polyatomic ion having the target isotope.7. The method of claim 1 , further comprising storing mass deviation correction data in memory claim 1 , wherein the mass deviation correction data is based on a target isotope and a cell gas.8. The method of claim 1 , wherein the ICP-MS comprises a triple quadrupole ICP-MS having first and second mass analyzers ...

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Номер записи: 91
17-06-2021 дата публикации

MULTIPOLE DEVICE AND MANUFACTURING METHOD

Номер: US20210183634A1
Автор: Bloomfield Stephen, GILL Matthew, WITTER Richard
Принадлежит: SHIMADZU CORPORATION

A method of manufacturing a multipole device includes the steps of: (a) forming an intermediate device by assembling a plurality of components including a plurality of precursor multipole electrodes, wherein the plurality of precursor multipole electrodes in the assembled device extend along and are distributed around a central axis; (b) forming a multipole device from the intermediate device by machining the precursor multipole electrodes within the intermediate device to provide a plurality of multipole electrodes having a predetermined spatial relationship; wherein a first component of the multipole device that includes a multipole electrode is attached non-permanently to a second component of the multipole device, the first component including a first alignment formation, and the second component including a second alignment portion configured to engage with the first alignment formation on the first component so as to facilitate alignment of the first component and the second component when the first component and the second component are attached, thereby allowing the first component to be detached from and then reattached to the second component while retaining the predetermined spatial relationship between the plurality of multipole electrodes. 1. A method of manufacturing a multipole device , the method including the steps of:(a) forming an intermediate device by assembling a plurality of components including a plurality of precursor multipole electrodes, wherein the plurality of precursor multipole electrodes in the assembled device extend along and are distributed around a central axis;(b) forming a multipole device from the intermediate device by machining the precursor multipole electrodes within the intermediate device to provide a plurality of multipole electrodes having a predetermined spatial relationship;wherein a first component of the multipole device that includes a multipole electrode is attached non-permanently to a second component of the ...

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Номер записи: 92
17-06-2021 дата публикации

QUADRUPOLE MASS SPECTROMETER

Номер: US20210183638A1
Автор: NISHIGUCHI Masaru
Принадлежит: SHIMADZU CORPORATION

A quadrupole mass spectrometer includes: a quadrupole mass filter including a pre-rod; an ionization chamber; and an ion optical system that guides ions generated in the ionization chamber to the pre-rod of the quadrupole mass filter, wherein: a potential of an exit side electrode of the ion optical system is lower than a potential of the ionization chamber and a potential of the pre-rod of the quadrupole mass filter; and there is no structure that has a higher potential than the exit side electrode and decelerates the ions between the exit side electrode and the pre-rod. 1. A quadrupole mass spectrometer , comprising:a quadrupole mass filter including a pre-rod;an ionization chamber; andan ion optical system that guides ions generated in the ionization chamber to the pre-rod of the quadrupole mass filter, wherein:a potential of an exit side electrode of the ion optical system is lower than a potential of the ionization chamber and a potential of the pre-rod of the quadrupole mass filter; andthere is no structure that has a higher potential than the exit side electrode and decelerates the ions between the exit side electrode and the pre-rod.2. The quadrupole mass spectrometer according to claim 1 , wherein:a distance from a central axis of the ion optical system and the quadrupole mass filter to the exit side electrode is equal to or less than half a distance from the central axis to the pre-rod; anda distance from the exit side electrode to the pre-rod is equal to or less than half a length of the pre-rod in the central axis direction.3. The quadrupole mass spectrometer according to claim 2 , further comprising:a partition wall that separates the ion optical system and the quadrupole mass filter and in which an ion passage hole is formed on the central axis of the ion optical system; wherein:at least a part of the exit side electrode of the ion optical system is arranged inside the ion passage hole so as to surround the central axis of the ion optical system ...

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Номер записи: 93
22-09-2022 дата публикации

Method and system for filtering ions defined by a targeted charge to mass ratio

Номер: US20220301846A1
Автор: TRAYKOV Emil
Принадлежит:

This invention has as its object a method of filtering an ion beam to isolate ions having a targeted charge to mass ratio, the method comprising: 142-. (canceled)43. A method of filtering an ion beam to isolate ions having a targeted charge to mass ratio , said method comprising:providing a quadrupole mass filter device comprising four, continuous or segmented, rods, extending parallel to each other from a quadrupole entrance to a quadrupole exit, said rods being arranged symmetrically and regularly around an axis forming a quadrupole longitudinal center axis and defining between them a continuous or segmented tubular volume, said rods being furthermore arranged opposite two by two in respectively a first transverse plane and a second transverse plane, perpendicular to each other,said method also comprising the steps of:emitting an ion beam towards the entrance of said quadrupole mass filter device, said ion beam being configured by shaping and/or pre-filtering means so as to have a limited radial dimension at least at the level of the entrance and to be directed along the longitudinal center axis of said device,applying an electrical field between the rods or rod segments of each pair of opposite rods, each field being defined by combined direct and alternative potentials, allowing ions having a charge to mass ratio in a given value range, defining a stability range, to oscillate within the lateral limits of the tubular volume or consecutive volume segments when moving through the quadrupole, in both the first and second transverse planes, and to exit said device, andcalibrating each of the electrical fields by adjusting the amplitudes of their DC potentials and the amplitudes and frequencies of their AC potentials, and also by adjusting the velocity of the ions entering the quadrupole, in order to create at least one oscillation node or exact focusing point where the oscillation patterns of the ions having said targeted charge to mass ratio, in both transverse ...

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Номер записи: 94
08-06-2017 дата публикации

Methods and Apparatus for Tandem Collision-Induced Dissociation Cells

Номер: US20170162371A1
Автор: OSER Harald, SCHOEN Alan E.
Принадлежит:

A method for operating a mass spectrometer so as to detect or quantify analytes, comprises: (a) identifying a selected-reaction-monitoring (SRM) transition to be used for each respective analyte; (b) determining a time duration required for a fragmentation reaction corresponding to each identified transition to proceed to a threshold percentage of completion; and (c) for each analyte, performing the steps of (i) isolating ions corresponding to a precursor-ion mass-to-charge (m/z) ratio of the respective transition; (ii) fragmenting the respective isolated ions in one of two fragmentation cells or fragmentation cell portions; and (ii) mass analyzing for fragment ions corresponding to a product-ion m/z ratio of the respective transition, wherein, for each analyte, the fragmentation cell or fragmentation cell portion that is used for fragmenting the isolated ions is determined from the time duration determined for the respective analyte. 1. A method for operating a mass spectrometer so as to detect a presence of or a quantity of each of one or more analytes of a sample , comprising:(a) for each of the one or more analytes, identifying one or more selected-reaction-monitoring (SRM) transitions to be used for detecting the presence or quantity of the respective analyte;(b) for each of the one or more identified SRM transitions, determining a time duration required for a fragmentation reaction corresponding to the respective SRM transition to proceed to a certain threshold percentage of completion;(c) ionizing the sample in an ionization source of the mass spectrometer so as to produce one or more populations of first-generation ions; and (d1) isolating a sub-population of a one of the one or more populations of first-generation ions corresponding to a precursor-ion mass-to-charge (m/z) ratio associated with the respective SRM transition;', '(d2) fragmenting the respective isolated sub-population of ions in a one of two fragmentation cells of the mass spectrometer so as ...

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Номер записи: 95
08-06-2017 дата публикации

Improved Quadrupole Robustness

Номер: US20170162374A1
Автор: Wildgoose Jason Lee
Принадлежит:

An apparatus for filtering ions is disclosed comprising a separation device for separating ions temporally according to a first physico-chemical property and a first quadrupole rod set for filtering ions according to their mass to charge ratio, wherein the first quadrupole rod set comprises a plurality of rods and wherein the first quadrupole rod set is arranged downstream of the separation device. The apparatus further comprises a control system arranged and adapted during a single cycle of separation of the separation device: (i) to operate the first quadrupole rod set in a first resolving mode of operation wherein ions of interest are selected by the first quadrupole rod set; and (ii) to operate the first quadrupole rod set in a second non-resolving or transmission mode of operation at separation times when substantially no ions of interest are present so that substantially no ions impact upon the rods of the first quadrupole rod set. 1. An apparatus for filtering ions comprising:a separation device for separating ions temporally according to a first physico-chemical property;a first quadrupole rod set for filtering said ions according to their mass to charge ratio, wherein said first quadrupole rod set comprises a plurality of rods and wherein said first quadrupole rod set is arranged downstream of said separation device; and (i) to operate said first quadrupole rod set in a first substantially resolving mode of operation at separation times when ions of interest are expected to emerge from said separation device so that said ions of interest are selected by or filtered according to their mass to charge ratio by said first quadrupole rod set; and', '(ii) to operate said first quadrupole rod set in a second substantially non-resolving or transmission mode of operation at separation times when substantially no ions of interest are expected to emerge from said separation device so that substantially no ions impact upon said rods of said first quadrupole rod set., ' ...

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Номер записи: 96
23-05-2019 дата публикации

MASS SPECTROMETER

Номер: US20190157064A1
Автор: Tateishi Yusuke
Принадлежит: SHIMADZU CORPORATION

A mass spectrometer including: an ionization chamber () that generates ions from a sample, a collision cell () located downstream from the ionization chamber (), a mass separation unit () located downstream from the collision cell (), an energy barrier unit () located between the collision cell () and the mass separation unit (), a voltage application unit () that applies a voltage to each of the ionization chamber (), the collision cell (), and the energy barrier unit (), and a control unit () that controls the voltage application unit () such that a potential of the ionization chamber () is set to a first potential, a potential of the collision cell () is set to a second potential that is lower than the first potential, and a potential of the energy barrier unit () is set to a third potential between the first potential and the second potential. 1. A mass spectrometer comprising:a) an ionization chamber configured to generate ions from a sample;b) a collision cell located downstream from the ionization chamber;c) a mass separation unit located downstream from the collision cell;d) an energy barrier unit located between the collision cell and the mass separation unit;e) a voltage application unit configured to apply a voltage to each of the ionization chamber, the collision cell, and the energy barrier unit; andf) a control unit configured to control the voltage application unit such that a potential of the ionization chamber is set to a first potential, a potential of the collision cell is set to a second potential that is lower than the first potential, and a potential of the energy barrier unit is set to a third potential between the first potential and the second potential.2. The mass spectrometer according to claim 1 , comprising:g) a gas introduction means configured to introduce a predetermined kind of gas at a prescribed pressure into the collision cell, whereinthe control unit further controls the gas introduction means to execute a first analysis in which ...

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Номер записи: 97
24-06-2021 дата публикации

AMPLIFIER AMPLITUDE CONTROL FOR A MASS SPECTROMETER

Номер: US20210193450A1
Автор: SMITH Johnathan Wayne
Принадлежит:

Control of an amplitude of a signal applied to a component of a mass spectrometer is described. In one aspect, a mass spectrometer includes a component and a resonant circuit to generate a radio frequency (RF) signal applied to the component. An amplitude control circuit can be inductively coupled with inductors of the resonant circuit to selectively discharge energy from the resonant circuit and, therefore, adjust the amplitude of the signal in particular situations. 1. A mass spectrometer , comprising:a component of the mass spectrometer;a resonant circuit configured to generate a first radio frequency (RF) signal applied to the component, the resonant circuit having a first resonant inductor used to store energy for generating the first RF signal at a first amplitude;an amplitude control circuit having a first amplitude control inductor that is inductively coupled with the first resonant inductor, and having a first diode that is coupled with the first amplitude control inductor; anda controller circuit configured to transfer energy from the first resonant inductor to the first amplitude control inductor to adjust the first RF signal from the first amplitude to a second amplitude by changing an operational state of the first diode.2. The mass spectrometer of claim 1 , wherein the first resonant inductor has a higher inductance than the first amplitude control inductor.3. The mass spectrometer of claim 1 , wherein the operational state of the first diode is changed from being in a reverse bias mode of operation to a forward bias mode of operation.4. The mass spectrometer of claim 1 , wherein the first RF signal is applied to a first pair of rods of the component claim 1 , wherein the component includes a second pair of rods claim 1 , the resonant circuit is configured to generate a second RF signal applied to the second pair of rods claim 1 , the resonant circuit having a second resonant inductor used to store energy for generating the second RF signal at the ...

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Номер записи: 98
16-06-2016 дата публикации

Cascaded-Signal-Intensifier-Based Ion Imaging Detector for Mass Spectrometer

Номер: US20160172173A1
Автор: SCHOEN Alan E., SMITH Johnathan Wayne
Принадлежит:

A detector system for a mass spectrometer comprises: a metal channel dynode (MCD) comprising at least one perforated metal plate configured to receive the exiting ions and eject electrons in response; a plurality of electron-to-photon converters arranged in a parallel stacked configuration, each such converter comprising a substrate plate having a phosphor coating on a first face; and an electrode film disposed on the phosphor coating; at least one photocathode, each of the at least one photocathode disposed between a respective pair of the plurality of electron-to-photon converters; an optical detector optically coupled a last one of the electron-to-photon converters; and at least one direct current power supply configured to apply, in operation, a respective bias electrical potential to the MCD and each of the electrode films and photocathodes. 1. A detector system for a mass spectrometer for detecting time-dependent two-dimensional distributions of ions that exit a mass analyzer of the mass spectrometer , the detector system comprising:(a) a metal channel dynode (MCD) comprising at least one perforated metal plate and configured to receive the exiting ions and eject electrons in response thereto; (b1) a substrate plate comprising first and second parallel faces;', '(b2) a phosphor coating on the first face of the substrate plate; and', '(b3) an electrode film disposed on the phosphor coating,', 'wherein the electron-to-photon converters are arranged in a parallel stacked configuration such that the electrode film of the substrate plate of a first one of the electron-to-photon converters faces the MCD and such that the electrode film of every succeeding electron-to-photon converter faces the second face of the substrate plate of the respective preceding electron-to-photon converter;, '(b) a plurality of electron-to-photon converters, each comprising(c) at least one photocathode, each of the at least one photocathode disposed between a respective pair of the ...

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Номер записи: 99
14-06-2018 дата публикации

A METHOD OF MASS ANALYSIS USING ION FILTERING

Номер: US20180166262A1
Автор: Moulds Richard
Принадлежит:

A method of mass spectrometry is disclosed comprising detecting the ions transmitted by a mass filter () with a detector (); changing the RF and/or DC voltage applied to the mass filter () during a voltage transition period so as to change the mass to charge ratio capable of being transmitted by the mass filter (); preventing ions from reaching the detector during the voltage transition period; and allowing ions to be transmitted to the detector () after the voltage transition period. 2. The method of claim 1 , comprising:measuring the signal output from the detector during said voltage transition period, when ions are prevented from reaching the detector, so as to determine the baseline signal of the detector;measuring the ion signal from the detector after the voltage transition period, when ions are allowed to be transmitted to the detector; andsubtracting said baseline signal from the measured ion signal.3. The method of claim 2 , changing the RF and/or DC voltage applied to said electrodes during a further voltage transition period so as to change said selected mass to charge ratio claim 2 , or said selected range of mass to charge ratios claim 2 , that the mass filter is capable of transmitting;preventing all ions from reaching the detector during the further voltage transition period; andallowing ions to be transmitted by the mass filter to the detector after the further voltage transition period.4. The method of claim 3 , comprising measuring the signal output from the detector during said further voltage transition period claim 3 , when ions are prevented from reaching the detector claim 3 , to determine an updated baseline signal for the detector;measuring the ion signal from the detector after the further voltage transition period, when ions are allowed to be transmitted to the detector; andsubtracting said updated baseline signal from the measured ion signal.5. The method of claim 1 , wherein the mass filter is a multipole mass filter comprising a ...

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Номер записи: 100