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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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Форма поиска

Поддерживает ввод нескольких поисковых фраз (по одной на строку). При поиске обеспечивает поддержку морфологии русского и английского языка
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Применить Всего найдено 85705. Отображено 200.
27-02-2012 дата публикации

ПРЕДМЕТНЫЙ СТОЛИК ДЛЯ ИЗОЛИРОВАННОЙ СРЕДЫ

Номер: RU2443392C2

Изобретение относится к медицинской технике и может быть использовано в системе для загрузки и перемещения объекта из изолированной зоны в систему диагностики вне изолированной зоны или из нее. Тоннель отходит от изолированной зоны. Тоннель имеет внутренний объем, открытый в изолированную зону и соединенный при функционировании с системой диагностики. Удлиненная платформа для размещения объекта, размеры которой позволяют помещать ее в тоннель, расположена в изолированной зоне. Основа, которая включает в себя механический привод, расположена в изолированной зоне и выполнена с возможностью совмещения платформы для размещения объекта с тоннелем и для ввода и вывода платформы для размещения объекта в тоннель и из тоннеля. В результате облегчается работа персонала в изолирующих костюмах или с иными причинами ограничения подвижности, достигается возможность обеззараживания предметного столика с помощью коррозионных химических веществ и возможность вывода модульного мотора только путем вывода ...

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27-09-2007 дата публикации

ПОДУШКА (ВАРИАНТЫ) И СПОСОБ ЕЕ ИЗГОТОВЛЕНИЯ (ВАРИАНТЫ)

Номер: RU2306837C2
Принадлежит: ТЕМПУР УОРЛД, ЛЛС. (US)

Изобретение относится к подушкам, а именно к подушкам терапевтического использования. Подушка (10) содержит вязкоэластичный рукав (18), образующий полость, и наполнитель (14), расположенный в полости, включающий гранулированный вязкоэластичный пеноматериал. По второму варианту подушка содержит вязкоэластичный рукав, образующий полость. Рукав содержит первый вязкоэластичный слой и второй вязкоэластичный слой, которые соединены с образованием полости, внутри которой расположен наполнитель. Первый слой ткани покрывает первый вязкоэластичный слой, второй слой ткани покрывает второй вязкоэластичный слой. Предложены способы изготовления указанных выше вариантов подушек. Обеспечивается правильное спрямленное расположение шеи и позвоночника пользователя подушки. 4 н. и 43 з.п. ф-лы, 3 ил.

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10-05-2013 дата публикации

ПРЕДМЕТ ПОСТЕЛЬНЫХ ПРИНАДЛЕЖНОСТЕЙ С ИНФЕКЦИОННЫМ КОНТРОЛЕМ

Номер: RU2481055C2

Герметичный предмет постельных принадлежностей с инфекционным контролем, такой как подушка, пуховое одеяло, матрац, подголовник и тому подобное, имеющий герметичный чехол и имеющий упруго деформирующийся материал наполнителя, содержащий средство вентиляции в чехле. Средство вентиляции содержит фильтрующую среду, содержащую фильтрующую мембрану для удаления частиц микробного размера. Фильтрующая среда также содержит армирующий слой материала для придания механической прочности фильтрующей среде, тем самым фильтрующая среда предоставляет возможность для протекания воздуха через нее, но является по существу непроницаемой для жидкости при поддержании барьера для частиц микробного размера. Обеспечивается эффективность блокирования загрязнителей при обеспечении передачи воздуха в и из изделия. 2 н. и 16 з.п. ф-лы, 9 ил.

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27-05-2005 дата публикации

УДОБНАЯ ПОДУШКА

Номер: RU2004137821A
Принадлежит:

... 1. Подушка, содержащая: вязкоэластичный рукав, образующий полость, и наполнитель, расположенный в этой полости, причем наполнитель включает гранулированный вязкоэластичный пеноматериал. 2. Подушка по п.1, в которой рукав включает: первый вязкоэластичный слой и второй вязкоэластичный слой, причем первый и второй вязкоэластичные слои соединены между собой для образования между ними полости, при этом наполнитель помещен между первым и вторым вязкоэластичными слоями. 3. Подушка по п.2, в которой первый вязкоэластичный слой и второй вязкоэластичный слой имеют толщину в диапазоне около 5-15 мм. 4. Подушка по п.3, в которой первый вязкоэластичный слой и второй вязкоэластичный слой имеют толщину около 10 мм. 5. Подушка по п.2, в которой первый вязкоэластичный слой и второй вязкоэластичный слой обладают удельной плотностью в диапазоне около 30-140 кг/м3. 6. Подушка по п.5, в которой первый вязкоэластичный слой и второй вязкоэластичный слой обладают удельной плотностью около 85 кг/м3. 7. Подушка ...

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30-06-1989 дата публикации

Автоматическая поточная линия для изготовления металлических листовых кузовов

Номер: SU1491323A3
Автор: Х

Изобретение относится к сварке, в частности к автоматическим системам для сборки и сварки различных моделей автомобильных кузовов в широкомассовом производстве. Цель - упрощение конструкции. Автомобильный кузов 3 транспортным средством 2 подается на рабочую позицию 1. Формовочный узел 6, соответствующий изготавливаемой модели кузова 3, из хранилища 4 кареткой 30 подается на конвейерное средство (КС) 5. Оно содержит две параллельные ветви цепи 9, охватывающей два или четыре ролика 8. Выдвижные пальцы формовочного узла 6 размещаются в отверстиях цепи 9. Узел 6 КС 5 подается на позиционирующее устройство 38. КС 5 узел 6 устанавливается в рабочее положение. Элементами разъема соединяют электрические, гидравлические и пневматические системы основания соответственно с электрическим источником питания, устройствами для подачи хладагента и воздуха формующего узла 6. Включают фиксаторы кузова и сварочное оборудование. После сварки формовочные узлы возвращаются в хранилища, а готовый кузов транспортным ...

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27-04-1972 дата публикации

Номер: DE0002152916A1
Автор:
Принадлежит:

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30-10-1991 дата публикации

BED

Номер: GB0002243291A
Принадлежит:

A bed has a mattress divided into a plurality of mattress portions (1) in a direction transverse to a human body lying thereon. The mattress portions are made individually elevatable and inclinable and a bath tub (8) is formed on the periphery of the mattress part as a whole. The bed facilitates the care of bedridden patients and the elderly. The mattress portions (1) are supported by tubes (3) which are elevatable by separately provided hydraulic cylinders or motor hoist. The support tubes (3) may include dirt extraction paths and water supply paths. The bath tub (8) may be provided with inwardly directed rubber gloves (10) to facilitate bathing of the patient. ...

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23-06-1993 дата публикации

A METHOD OF AND APPARATUS FOR SUPPORTING THE HUMAN BODY

Номер: GB0002224434B
Принадлежит: SHEK KWEI CHUN, KWEI CHUN * SHEK

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21-07-1998 дата публикации

Bed/bath

Номер: GB0002318509A8
Автор: AKADO KOJI, KOJI AKADO
Принадлежит:

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21-06-2000 дата публикации

Free form furniture

Номер: GB0002344756A
Принадлежит:

An upholstery furniture item (100) comprises a casing (118) of flexible, air impermeable material filled with spherical beads (30) of expanded polystyrene that flow around the body of a person seated in the item to closely follow the contours of the body. In the bottom of the casing is an airtight inflatable air chamber (190) for compensating for volume changes that arise from the crushing or abrading of the beads after repeated use. Flexible elastic members (120, 128, 140, 160, 168, 184) are provided to help the furniture item retain its shape.

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14-07-1965 дата публикации

Improvements in or relating to a gymnastic floor covering

Номер: GB0000998101A
Автор:
Принадлежит:

... 998,101. Gymnastic mats. NISSEN CORPORATION. April 2, 1962 [Dec. 21, 1961], No. 12594/62. Heading A4S. A gymnastic mat 10 is composed of rectangular sections 11 of foamed polyethylene or rubber inside top and bottom covers 13, 15 of canvas coated with a polyvinyl resin, the covers 13, 15 being sewn together along the bottom cover so that the mat may be folded. The mats may have fastening elements to join a number of mat together.

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03-09-1981 дата публикации

Support Device

Номер: GB2069917A
Автор: Burnett, John Seymour
Принадлежит:

A support device, suitable for the physically handicapped, and also for packaging delicate objects, consists of an airtight flexible bag filled with a granular material coated with an adhesive. A non-return valve is provided to allow a partial vacuum to be established within the bag. In use, the bag when non-evacuated of air, is pushed against a body to be supported so that the granular material flows and assumes a shape closely conforming to the body. Air is then evacuated from the bag and as a result the granular material is compressed into a rigid mass in the conformed shape. The mass is then made permanently rigid by activating the adhesive coating, for example with microwave radiation.

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12-10-1983 дата публикации

SUPPORT DEVICE

Номер: GB0002069917B
Автор:
Принадлежит: BURNETT J S

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13-09-1972 дата публикации

Номер: GB0001289115A
Автор:
Принадлежит:

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08-03-1995 дата публикации

Vehicle seat cushion

Номер: GB0009500846D0
Автор:
Принадлежит:

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16-03-1977 дата публикации

APPARATUS COMPRISING A SEAT MATTRESS OR LIKE CUSHIONING DEVICE

Номер: GB0001467201A
Автор:
Принадлежит:

... 1467201 Mattresses &c SOC NATIONALE DE POUDRES ET EXPLOSIFS SA and J LOEB 24 March 1975 [27 March 1974] 12260/75 Heading A4M A mattress, seat or like cushioning device comprises a pair of elastic skins 1, 2 united to define a sealed envelope filled with resilient and deformable bodies 3, e.g. spherical and of expanded polystyrene, and a pressure reduction assembly 4 for creating and maintaining a pressure reduction within the envelope whereby the bodies become imbricated and the device moulds to the shape of the user, the pressure reduction assembly comprising a gas generator 6 communicating with the injection side of an aspirator having a collector communicating with the interior of the envelope through a one-way valve 10. The assembly includes a striker 7 and an ejector 8 open to atmosphere through a silencer 9 the gas generator 6 including an explosive block with a front coated with an ignition composition that is ignited by the flame of a percussion cap placed in a carrier to be ignited ...

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11-03-1981 дата публикации

BED MATTRESSES

Номер: GB0001585662A
Автор:
Принадлежит:

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03-11-1976 дата публикации

BODY SUPPORT MEANS

Номер: GB0001454292A
Автор:
Принадлежит:

... 1454292 Mattresses &c G D SEARLE & CO Ltd 5 Feb 1974 [24 Feb 1973] 9193/73 Heading A4M [Also in Division A5] A cushion, mattress or the like for supporting a human body or part thereof to prevent bed-sores comprises a flexible, impervious case 2 containing a filling 3 consisting of a mixture of a viscous liquid and an insoluble solid filler the movement of which is restrained by the viscous liquid. The liquid may comprise a gelatine and the solid filler may comprise sawdust, vermiculate granules, mica powder, steam treated smoke particles or pre-expanded polystyrene particles, beads, spheres or platelets. The filling 3 occupies at least 50% of the available volume of the case 2. In one embodiment, Fig. 1, a pad 1 is enclosed in outer casings 4, 5 providing insulation and ventilation. The pad may be shaped to any part of the user, e.g. shoulders, or may be used between a limb stump and an artificial limb. In another embodiment, Fig. 2, a heel pad 6 has a base part 7 comprising a base 8 with ...

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26-11-1980 дата публикации

ARRANGEMENT TO SIMULATE AN ENVIRONMENT WITHIN A PREDETERMINED SPACE

Номер: GB0001579969A
Автор:
Принадлежит:

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17-10-1979 дата публикации

WATER BED

Номер: GB0001553942A
Автор:
Принадлежит:

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15-05-2007 дата публикации

CUSHION, IN PARTICULAR FOR THE EMPLOYMENT IN THE CONTEXT OF THERAPEUTIC MEASURES

Номер: AT0000359844T
Принадлежит:

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15-04-2009 дата публикации

STIMULATION ACTUATOR FOR THE MOVEMENT OF EDITION-FLAT

Номер: AT0000427681T
Принадлежит:

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15-11-2009 дата публикации

PROCEDURE FOR THE EQUIPMENT OF THE UNDERBODY OF A PIECE OF FURNITURE

Номер: AT0000447344T
Принадлежит:

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15-09-2010 дата публикации

BABY BED FROM CARDBOARD

Номер: AT0000479363T
Автор: KENAN RUTH, KENAN, RUTH
Принадлежит:

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15-09-2011 дата публикации

BED SYSTEM

Номер: AT0000520329T
Принадлежит:

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15-03-1995 дата публикации

COUCH FOR AN INFANT

Номер: AT0000215893A
Автор:
Принадлежит:

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15-11-2007 дата публикации

A MATTRESS

Номер: AT0000377987T
Принадлежит:

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15-09-1995 дата публикации

DEVICE FOR THE ANNOUNCEMENT OF FALLING.

Номер: AT0000126992T
Принадлежит:

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15-06-1983 дата публикации

EDITION FUER A LYING OR SITTING PERSON.

Номер: AT0000003363T
Автор: FORSTER, PETER
Принадлежит:

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15-06-1991 дата публикации

CARRIER SYSTEM FOR THE MISALIGNMENT OF DAEMPFERFLUESSIGKEIT AND METHOD TO ITS PRODUCTION.

Номер: AT0000063442T
Принадлежит:

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15-09-1997 дата публикации

MOUNTING DEVICE AND - PROCEDURES FOR A PATIENT EDITION SYSTEM

Номер: AT0000157240T
Принадлежит:

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15-06-1998 дата публикации

IMPROVED STRETCHER

Номер: AT0000166568T
Принадлежит:

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15-12-2005 дата публикации

FLEXIBLE BODY, PROCEDURE FOR ITS PRODUCTION AND MATTRESS WITH SUCH BODY

Номер: AT0000312795T
Принадлежит:

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15-08-2005 дата публикации

SUPPORTING DEVICE, LIKE FOR EXAMPLE A CUSHION

Номер: AT0000300896T
Принадлежит:

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15-01-2003 дата публикации

SEAT

Номер: AT0000230576T
Принадлежит:

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15-09-2002 дата публикации

DEVICE FOR PRODUCING UNDULATION

Номер: AT0000223687T
Принадлежит:

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15-01-2005 дата публикации

PATIENT STORAGE SPACES AND PROCEDURES FOR YOUR OPERATION

Номер: AT0000284636T
Принадлежит:

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15-10-2004 дата публикации

HEAD RESTRAINT FOR INFANTS

Номер: AT0000278345T
Принадлежит:

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28-02-2000 дата публикации

Ob/gyn stretcher

Номер: AU0005548599A
Принадлежит:

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22-03-2007 дата публикации

Convective cushion with positive coefficient of resistance heating mode

Номер: AU2006291202A1
Автор: FEHER STEVE, STEVE FEHER
Принадлежит:

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26-10-2006 дата публикации

Adjustable bed

Номер: AU2006237564A1
Принадлежит:

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28-08-1975 дата публикации

A MATERNITY PROTECTION DEVICE

Номер: AU0006610974A
Принадлежит:

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17-03-1992 дата публикации

SELF-REINITIALIZING PADDING DEVICE

Номер: AU0008626391A
Принадлежит:

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14-09-1995 дата публикации

Body support for a baby

Номер: AU0000662772B2
Принадлежит:

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30-01-1997 дата публикации

Improved stretcher

Номер: AU0000675267B2
Принадлежит:

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02-12-1999 дата публикации

Apparatus for use in preventing decubitis ulcers and in relaxation therapy

Номер: AU0000713407B2
Принадлежит:

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16-02-1996 дата публикации

Multi-layer conformable support system

Номер: AU0002970995A
Принадлежит:

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01-09-1993 дата публикации

Multipositional infant support system

Номер: AU0003482593A
Принадлежит:

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16-12-1999 дата публикации

Air mat

Номер: AU0003314199A
Принадлежит:

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13-09-1984 дата публикации

SELF-SEALING PUNCTURABLE ARTICLE

Номер: AU0002526784A
Принадлежит:

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25-07-1991 дата публикации

A METHOD OF AND APPARATUS FOR THE MEDICAL-THERAPEUTIC TREATMENT OF THE HUMAN BODY

Номер: AU0004438589A
Принадлежит:

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19-05-2005 дата публикации

ENHANCER DEVICE FOR ENHANCING THE UTILITY OF A USER'S BED

Номер: CA0002542495A1
Автор: DAWES, JORDAN
Принадлежит:

The present invention relates to an enhancer device (100), and more particularly, to an enhancer device for enhancing the utility and look of a user's bed. The enhancer device comprises a support member securing mechanism (102) for securing the enhancer device; a support member (104) detachably attached with the support member securing mechanism, the support member having a base end (110) and a distal end (108); and a fastener (106) connected with the distal end of the support member. Once secured, an attachment (112) may be connected with the fastener. The attachment allows a user to support a body part, or alternatively, display decorative or items, thereby enhancing the utility and look of the user's bed.

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17-11-1981 дата публикации

WATERPROOF LAMINATE

Номер: CA0001112551A1
Принадлежит:

Подробнее
14-08-1973 дата публикации

CUSHION

Номер: CA0000932083A1
Автор: IKEDA TAKEO
Принадлежит:

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01-08-2003 дата публикации

REVERSED AIR MATTRESS

Номер: CA0002416861A1
Автор: VANSTEENBURG, KIP P.
Принадлежит:

A person-support apparatus for use with a suction source comprises a core having one or more foam elements and a cover having an interior region in which the core is situated. The cover is in fluid communication with the suction source and the suction source operates to evacuate a portion of air from the interior region so that at least one of the foam elements is partially compressed within the interior region of the cover due to the evacuation of the portion of air.

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08-05-1973 дата публикации

SURGICAL PAD AND MATTRESS AND APPARATUS FOR DECUBITUS ULCER MANAGEMENT

Номер: CA0000926040A1
Автор: TRENCHARD S
Принадлежит:

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20-05-2008 дата публикации

MULTI-WALLED GELASTIC MATERIAL

Номер: CA0002610549A1
Принадлежит: PERRY + CURRIER

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19-07-1977 дата публикации

FOLD-OPEN CONVERTIBLE OCCUPANT-RECEIVING UNIT OF FURNITURE

Номер: CA0001013902A1
Автор: PETERSILIE FRANK W
Принадлежит:

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13-02-2006 дата публикации

SECTIONAL NON-SLIP MATTRESS

Номер: CA0002525570A1
Автор: LITVAK, VERA
Принадлежит:

The sectional non-slip mattress includes a support frame that is divided into a plurality of compartments, along with a plurality of cushions. The cushions engage one another to form a larger mattress, and each cushion is held in place with respect to the support frame and to the other cushions by engagement with the compartments of the support frame.

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17-02-2015 дата публикации

CONVERTIBLE BLANKET FOR CONVERTING TO TOY

Номер: CA0002783191C

A convertible blanket, method of converting a convertible blanket and kit including a convertible blanket are described. A convertible blanket includes a fabric blanket portion having a top end, a bottom end and sides. The convertible blanket also includes one or more front-of-creature features defining a front of the creature. The front-of-creature features are disposed on a surface of the fabric blanket portion to offset the front of the creature from each of the sides of the fabric blanket portion. The convertible blanket also includes one or more fasteners attached to the fabric blanket portion. The one or more fasteners are configured to releasably hold the convertible blanket in a position where the toy is formed.

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09-03-2012 дата публикации

ANIMAL-THEMED SLEEP SYSTEM

Номер: CA0002755890A1
Принадлежит:

A sleep system includes a sack and a sleeping bag. The sack includes an exterior surface, an interior surface, a closed end and an open end. The exterior surface of the closed end includes decorative features of an animal head. The sleeping bag is configured to be stored in the sack when not in use. The sleeping bag includes a fastener that detachably connects at least two edges of the sleeping bag and has a fastener pull. The fastener pull includes an animal tail corresponding with the animal head located on the exterior surface of the closed end of the sack.

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13-02-2018 дата публикации

SWADDLE BLANKET

Номер: CA0002760609C

A swaddle blanket and mattress attachment device. The swaddle blanket includes a top end and a bottom end with a pocket disposed at the bottom end and configured to enclose an infants legs. A first side of the blanket is configured to wrap over the infant in one direction and a second side of the blanket is configured to wrap over the infant and the first side in the other direction. A fastener is disposed on the second side of the blanket and is configured to secure the second side in place over the first side. At least one attachment strap is secured to the swaddle blanket. When the blanket is in an attachment position the attachment strap extends away from the swaddle blanket. The attachment strap including a first mating pair fastener. The mattress attachment device is configured to be secured to a sleeping surface. The mattress attachment device includes at least one second mating pair fastener that is securable to the first mating pair fastener.

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28-07-1987 дата публикации

LOW FRICTION BED PAD

Номер: CA0001224889A

A bed pad structure is provided for the prevention of bed sores or pressure ulcers. The bed pad includes a pouch portion having an upper layer formed from a porous low friction material and a lower layer formed from a flexible impervious sheet material. The pouch portion is further constructed to enable easy insertion and removal of a lubricated insert in between the upper and lower layers. Lubrication from the insert can flow through the porous upper layer. The low friction characteristics of the upper layer plus the presence of the lubricant adjacent the patient substantially prevents friction and related wear which are contributing factor to the occurrence of bed sores.

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11-03-1980 дата публикации

ELEVATED MATTRESS

Номер: CA1073562A
Принадлежит: VINEBERG ARTHUR, VINEBERG, ARTHUR

An auxiliary elevated wedge-shaped mattress of a resilient open cell synthetic resin foam having a sloping surface long enough to give support to the head, neck and thorax of a reclining patient with his legs supported by the horizontal mattress.

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17-03-1981 дата публикации

MASSAGING FURNITURE

Номер: CA1097777A

Nonrotating vibrator motors are mounted on a rigid member in furniture. Electric power at different frequencies or energy levels is supplied to the respective vibrator motors. Frequency differences in the vibrations result in moving interference waves being produced in the rigid member which waves are imparted to the user of the furniture who experiences a massaging effect. Means are provided for enabling the user to control the frequency differential and amplitudes of the driving currents.

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30-10-1973 дата публикации

COUSSIN

Номер: CA936287A
Автор:
Принадлежит:

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10-02-1976 дата публикации

HEAT BARRIER TEXTILE MATERIAL

Номер: CA983631A
Автор:
Принадлежит:

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04-03-1975 дата публикации

BED

Номер: CA963603A
Автор:
Принадлежит:

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10-07-1979 дата публикации

INFLATABLE CELLULAR ASSEMBLIES OF PLASTIC MATERIAL

Номер: CA1058015A

Pneumatic structural and cushioning material of plastic sheets, bands, and/or tubes, which are compartmentized into a plurality of chambers. The material is capable of convenient and economical storage and shipment in a collapsed state and rapid inflation to an operative state at the point of use. The chambers embody one-way valving arrangements to maintain the chambers in an expended state over long periods of time, rendering the product useful in cushioning loads during shipment by land, air or water; in safety devices for humans in vehicle bumpers, air cushions, and buoyant devices of all types; and in structural assemblies of either temporary or permanent types to attain heat and sound insulation effects.

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08-03-1988 дата публикации

CARRIER FOR SUPPORTING USER'S BODY

Номер: CA0001233867A1
Автор: TANIGUCHI HARUSHIGE
Принадлежит:

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21-11-1978 дата публикации

SOUND REPRODUCTION SYSTEM AND DEVICE

Номер: CA0001042812A1
Автор: YAMADA KYOTA
Принадлежит:

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27-07-2000 дата публикации

HEAD SUPPORT DEVICE FOR INFANTS

Номер: CA0002358513A1
Принадлежит:

... ▓▓▓A suitable support device (10) for newborns including premature babies ▓comprises a doughnut-shaped structure having a gel filled casing (12) of about ▓five to six inches outer diameter with a central aperture (18) of about two to ▓three inches in diameter. The structure provides an annular tube having about ▓a 1 to 2 inch diameter. The tube is preferably circular in cross section at ▓the rear or head region (14) and preferably flattened to provide a generally ▓oval cross-section at the front or neck region (16). The casing (12) is filled ▓with a cohesive gel mass (20) such as silicone gel or silicone elastomers with ▓sufficiently cross-linked polysiloxane networks to substantially retain a ▓selected shape despite the force of a limited incident weight.▓ ...

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17-02-2000 дата публикации

STRETCHER FOR OBSTETRICS OR GYNECOLOGY

Номер: CA0002337472A1
Принадлежит:

A patient support apparatus (10) includes a base (12), a frame (14) coupled to the base (12), and a deck (16) coupled to the frame (14). The frame (14) includes a storage portion. The deck (16) includes a head section (20), a seat section (22) and first and second laterally spaced apart outer leg support sections (24, 26) adjacent the seat section (22). The seat section (22) and the first and second outer leg support sections (24, 26) are configured to define a central opening (15) therebetween. The apparatus (10) also includes a removable center leg support (17) configured for movement between a first position located within the central opening (15) and coupled to the deck (16) to provide a portion of the deck (16) and a second storage position detached from the deck (16) and located in the storage portion of the frame (14) and below the deck (16).

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09-12-1986 дата публикации

THERMAL INSULATION LAYER

Номер: CA0001214983A1
Автор: POLLOCK JAMES F
Принадлежит:

Подробнее
10-07-1979 дата публикации

INFLATABLE CELLULAR ASSEMBLIES OF PLASTIC MATERIAL

Номер: CA0001058015A1
Принадлежит:

Подробнее
09-08-1988 дата публикации

RESILIENT SUPPORTING DEVICE

Номер: CA0001240414A1
Автор: HESSEL LASSE
Принадлежит:

Подробнее
17-03-1981 дата публикации

MASSAGING FURNITURE

Номер: CA0001097777A1
Принадлежит:

Подробнее
11-03-1980 дата публикации

ELEVATED MATTRESS

Номер: CA0001073562A1
Автор: VINEBERG ARTHUR
Принадлежит:

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13-08-2013 дата публикации

MATTRESS ENCASEMENT FOR PREVENTING BED BUG ESCAPEMENT VIA A ZIPPER OPENING

Номер: CA0002624540C
Принадлежит: JAB DISTRIBUTORS, LLC., JAB DISTRIBUTORS LLC

A mattress encasement made of bug impervious fabric provides a zipper opening for removal of the mattress. A foam pad is stitched at an end of the zipper closure such that when the zipper is located at or near the end, a channel is provided to prevent or obstruct the escapement of bed bugs via the channel and out from a mattress encased by the mattress encasement.

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15-09-2008 дата публикации

MATTRESS ENCASEMENT FOR PREVENTING BED BUG ESCAPEMENT VIA A ZIPPER OPENING

Номер: CA0002916742A1
Принадлежит:

A mattress encasement made of bug impervious fabric provides a zipper opening for removal of the mattress. A foam pad is stitched at an end of the zipper closure such that when the zipper is located at or near the end, a channel is provided to prevent or obstruct the escapement of bed bugs via the channel and out from a mattress encased by the mattress encasement.

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08-01-2013 дата публикации

CHANGING STATION

Номер: CA0002679666C

The disclosed changing station (4100) may support a small person, such as a baby. The station (4100) may comprise a platform (4102), a support structure (4104), and a mounting structure (4106). The platform (4102) may be rotatable from a vertical1 storage position to a horizontal use position along a rotational axis. The support structure (4104) may have a rotatable support member (4130) that rotates along the rotational axis. The mounting structure (4160) may be used for mounting the support structure (4140) to a vertical wall.

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24-12-2013 дата публикации

MATTRESS ENCASEMENT FOR PREVENTING BED BUG ESCAPEMENT VIA A ZIPPER OPENING

Номер: CA0002817702C
Принадлежит: JAB DISTRIBUTORS, LLC., JAB DISTRIBUTORS LLC

A mattress encasement made of bug impervious fabric provides a zipper opening for removal of the mattress. A foam pad is stitched at an end of the zipper closure such that when the zipper is located at or near the end, a channel is provided to prevent or obstruct the escapement of bed bugs via the channel and out from a mattress encased by the mattress encasement.

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19-07-1994 дата публикации

ANIMAL MATTRESS AND METHOD OF MAKIMG THE SAME

Номер: CA0002087464A1
Принадлежит:

In an animal stall a brisket board extends along the front end portion of the floor, and a keeper board extends along the rear end portion of the floor. An animal mattress is disposed on the floor between the brisket board and the keeper board, with the mattress extending over the keeper board. The mattress includes a fabric enclosure having a plurality of separate compartments within the enclosure, and comminuted rubber from used vehicle tires is disposed within each compartment. A top fabric blanket is disposed over the mattress with an end of the blanket attached to the keeper board, and an opposed end of the blanket attached to the brisket board.

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07-09-1992 дата публикации

EMERGENCY PATIENT EVACUATION SYSTEM

Номер: CA0002037652A1
Принадлежит:

Подробнее
04-07-1996 дата публикации

HEEL PRESSURE MANAGEMENT APPARATUS AND METHOD

Номер: CA0002166442A1
Принадлежит:

A sleep support surface includes a mattress having at least two bladders located adjacent a foot end. The bladders each have a predetermined, adjustable internal pressure. The pressure in at least one of the bladders is selectively and independently reduced to provide pressure relief on the heels of the patient lying on the mattress. The pressure in a bladder located toward the head end of the mattress and adjacent the at least one bladder is increased. This pressure increase advantageously provides the lifting force under the calves of the patient to reduce further pressure on the patient's heels. A visual indication of the location each of the at least two bladders in the mattress is provided to facilitate selection of the at least one bladder in which to reduce pressure during the pressure reducing step, thereby providing pressure relief on the heels of the patient lying on the mattress. The at least one bladder in which to reduce the pressure is selected based on a position of the patient's ...

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26-07-1994 дата публикации

MATTRESS WITH MEANS TO SUPPORT BEDCLOTHES ABOVE A USER'S FEET

Номер: CA0002071475C
Автор: LOU KWONG L, LOU, KWONG L.
Принадлежит: LOU KWONG L, LOU, KWONG L.

A flexible member which extends about foot high is transversely mounted at the foot end of the flat mattress for supporting bedclothes at the foot end area to reduce the pressure on the upward pointed toes when a person sleeps face-up. Detachable and/or pivotable mounting means allow the flexible member to be mounted on either side and on either end of said mattress. Further, provision may be made to allow the flexible member to be selectively positioned along the length of the mattress. The flexible member is provided with electrical heating device and thermostat control for warming up the feet area.

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28-02-1992 дата публикации

SELF-REINITIALIZING PADDING DEVICE

Номер: CA0002090415A1
Принадлежит:

... 2090415 9203070 PCTABS00010 A self-reinitializing padding device (10) having at least two fluidly connected chambers (40, 50) which contain flowable material for use in applications where it is desirable to reinitialize the padding device (10) for subsequent use in absorbing and/or distributing impact forces. One application for which the padding device (10) is particularly well suited is as a foot padding device (10) in footwear. The impact force of the user's foot deforms a primary chamber (40), thereby forcing some of the flowable material contained therein to flow into a plurality of secondary chambers (50). The rate of deformation of the primary chamber (40) exceeds the flow rate into the secondary chamber (50), thereby providing a cushioning effect. When the portion of the footwear coinciding with the primary chamber (40) loses contact with the ground, the force is removed from the primary chamber (40), thereby allowing the secondary chamber (50) to contract and force some of the ...

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05-01-2012 дата публикации

Side seal members for a dock seal

Номер: US20120000150A1
Принадлежит: Individual

Side seal member for a loading dock seal are disclosed. An example dock seal includes a backer to couple the dock seal to a wall and a resiliently compressible member supported by the backer. A pliable cover encases the compressible member. The pliable cover has a first end overlapping a second end to define a separable joint that is to be disposed between the backer and the wall when the dock seal is coupled to the wall.

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05-01-2012 дата публикации

Compositions Produced Using Enteric Pathogens and Methods of Use

Номер: US20120003269A1
Принадлежит: Epitopix LLC

The present invention provides compositions including polypeptides having the characteristics of polypeptides expressed by a reference microbe such E. coli or Salmonella . Examples of Salmonella strains that can be used include, for instance, S. enterica serovar Newport, S. enterica serovar Enteritidis, S. enterica serovar Typhimurium, and S. enterica serovar Dublin. Also provided are compositions including polypeptides having a particular molecular weight and a mass fingerprint that includes polypeptide fragments having a particular set of masses, or polypeptides having an amino acid sequence with at least about 95% identity with an amino acid sequence, wherein the polypeptide has seroreactive activity. The present invention also provides methods of making and methods of using such compositions.

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12-01-2012 дата публикации

Breathable blanket

Номер: US20120005831A1
Принадлежит: Breathablebaby LLC

A breathable blanket may be made from a breathable mesh material to improve airflow through the blanket. The breathable blanket may include a multi-layer material having a combination of light-weight liner fabric and a mesh fabric. The blanket may be have a shape similar to an animal and include attachments, such as a stuff polyfill head. Additionally, the blanket may include ornamental additions of satin to further convey the animal shape.

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12-01-2012 дата публикации

Integrated containment system

Номер: US20120006202A1
Автор: Mark Huza, Thomas C. Morse
Принадлежит: Individual

Embodiments of the invention generally provide a containment system having integrated bubble tight-dampers. In another embodiment, the containment system includes an integral auto-scan mechanism disposed in the housing of the containment system so that a filter element, disposed in the housing, may be leak tested without accessing the interior of the housing. In yet another embodiment, a method for testing a filter disposed in a containment system includes challenging an upstream side of a filter element disposed in a housing of the containment system with a test aerosol, and automatically moving a probe disposed within the housing to obtain samples for leak testing.

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19-01-2012 дата публикации

Arsenic sorbent and method for remediating arsenic-contaminated material

Номер: US20120012532A1
Принадлежит: Kanazawa University NUC

An arsenic sorbent includes monohydrocalcite that has been precipitated by mixing an aqueous solution of a soluble carbonate or a carbonate with an aqueous solution that includes an Mg 2+ ion and a Ca 2+ ion in a ratio “Mg/Ca” of 0.3 or more, the monohydrocalcite having a molar ratio “Mg/(Ca+Mg)” of 0.1 or less. The arsenic sorbent exhibits a high arsenic sorption ability, and can stably retain a sorbate. A purification method using the same is also disclosed.

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26-01-2012 дата публикации

METHODS FOR TREATING IgE-MEDIATED DISORDER

Номер: US20120020979A1
Автор: Andrea Cerutti, KANG Chen
Принадлежит: CORNELL UNIVERSITY

This invention relates to methods of treating IgE mediated disorders such as allergy and asthma based on activating surface-bound IgD molecules on basophils. The invention also relates to methods of making IgD, as well as methods of screening for antimicrobial agents from IgD-activated basophils.

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02-02-2012 дата публикации

Modified heparinase iii and methods of sequencing therewith

Номер: US20120027744A1
Принадлежит: Massachusetts Institute of Technology

The invention relates to heparinase III and mutants thereof. Modified forms of heparinase III having reduced enzymatic activity which are useful for a variety of purposes, including sequencing of heparin-like glycosaminoglycans (HLGAGs), removing active heparan sulfate from a solution, inhibition of angiogenesis, etc. have been discovered according to the invention. The invention in other aspects relates to methods of treating cancer and inhibiting tumor cell growth and/or metastasis using heparinase III, or products produced by enzymatic cleavage by heparinase III of HLGAGs.

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16-02-2012 дата публикации

Fire Resistant Flange for Removable Top Panels for Use in Mattress Assemblies

Номер: US20120036644A1
Автор: Jeremy B. Lynn
Принадлежит: Dreamwell Ltd

A removable top panel for a mattress assembly generally includes at least one layer having length and width dimensions sufficient to support a reclining body of the user; a mechanical fastener component disposed at about a perimeter edge of a bottom facing surface of the at least one layer, wherein the mechanical fastener is configured to provide releasable engagement to an underlying mattress body; and a layer of a fire resistant material extending inwardly from the perimeter edge. Also disclosed are mattress assemblies including the removable top panel.

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15-03-2012 дата публикации

Filter unit, filtration method and system

Номер: US20120060820A1
Принадлежит: Blissfield Manufacturing Co

A filter unit, system and method for removing grease, oil and other particulates from air, for example, in a kitchen environment. The filter unit includes a housing having an upstream side, an downstream side, and a cavity therebetween, a heat exchanger disposed within the cavity and comprising at least two tubes, at least one entrance aperture disposed on the upstream side of the housing and defined by at least one fin, at least one baffle disposed on the downstream side of the housing so as to be oppositely disposed from the at least one entrance aperture, and at least one exit aperture disposed on the downstream side of the housing adjacent the at least one baffle. The baffle and fin define at least one flow path through the housing and around the tubes.

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22-03-2012 дата публикации

Treatment of subterranean formations

Номер: US20120067585A1
Принадлежит: Polymer Ventures Inc, WATER MARK Tech Inc

A method of preparing and using a subterranean formation stabilization agent. The stabilization agent includes a guanidyl copolymer and may be admixed with a fracturing fluid and optionally brine. The stabilization agent is effective in preventing and/or reducing, for example, clay swelling and fines migration from a subterranean formation contacted with the stabilization agent.

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29-03-2012 дата публикации

Novel malaria vaccine

Номер: US20120076816A1
Принадлежит: Osaka University NUC

The present invention provides a vaccine for preventing and/or treating Plasmodium falciparum infections, which comprises a polypeptide set forth in SEQ ID NO: 1 or represented by formula (1), and an adjuvant. X 1 -A-B-X 2 -Y-X 3 -(Y)n-X 4 -(Y)n-X 5   (1) (In the formula, X 1 represents the 1st to 7th amino acid residues in a polypeptide set forth in SEQ ID NO: 1; X 2 represents the 73th to 177th amino acid residues; X 3 represents the 178th to 258th amino acid residues; X 4 represents the 259th to 289th amino acid residues; X 5 represents the 290th to 334th amino acid residues; A represents an 8-mer repeat sequence contained in a 47-kd region of SERA polypeptide of Plasmodium falciparum ; B represents a sequence of a serine-rich region contained in a 47-kd region of SERA polypeptide of Plasmodium falciparum ; Y represents any one selected from A-A, A-B, and B; and n is an integer of 0 or 1.)

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29-03-2012 дата публикации

Cyclic olefin compound, photoreactive polymer, and alignment layer comprising the same

Номер: US20120076954A1
Принадлежит: LG Chem Ltd

Disclosed therein are a cyclic olefin compound, a photoreactive polymer, and an alignment layer comprising the photoreactive polymer, where the cyclic olefin compound can be used to provide the photoreactive polymer having not only excellences in liquid crystal alignment and alignment rate but also readiness for change in the alignment direction depending on the polarization direction.

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05-04-2012 дата публикации

Novel albumin-free factor viii formulations

Номер: US20120083446A1

An albumin-free Factor VIII formulation comprising, 4% to 10% of a bulking agent selected from the group consisting of mannitol, glycine and alanine; 1% to 4% of a stabilizing agent selected from the group consisting of sucrose, trehalose, raffinose, and arginine; 1 mM to 5 mM calcium salt; 100 mM to 300 mM NaCl; and a buffering agent Alternatively, the formulation can comprise 2% to 6% hydroxyethyl starch; 1% to 4% of a stabilizing agent selected from the group consisting of sucrose, trehalose, raffinose, and arginine; 1 mM to 5 mM calcium salt; 100 mM to 300 mM NaCl; and a buffering agent. In a further embodiment, the formulation can comprise: 300 mM to 500 mM NaCl; 1% to 4% of a stabilizing agent selected from the group consisting of sucrose, trehalose, raffinose, and arginine; 1 mM to 5 mM calcium salt; and a buffering agent.

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12-04-2012 дата публикации

Hydrocarbon recovery process

Номер: US20120085555A1

Hydrocarbons are recovered from subterranean formations by waterflooding. The method comprises passing an aqueous displacement fluid via an injection well through a porous and permeable sandstone formation to release oil and recovering said released oil from a production well spaced from said injection well, wherein (a) the sandstone formation comprises at least one mineral having a negative zeta potential under the formation conditions; (b) oil and connate water are present in the pores of the formation; and (c) the fraction of the divalent cation content of the said aqueous displacement fluid to the divalent cation content of said connate water is less than 1.

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19-04-2012 дата публикации

GNA1870-Based Vesicle Vaccines for Broad Spectrum Protection Against Diseases Caused by Neisseria Meningitidis

Номер: US20120093867A1
Принадлежит: Individual

The present invention generally provides methods and compositions for eliciting an immune response against Neisseria spp. bacteria in a subject, particularly against a Neisseria meningitidis serogroup B strain.

Подробнее
03-05-2012 дата публикации

Methods of administering pif agonist peptides and uses thereof

Номер: US20120107318A9
Автор: Eytan R. Barnea
Принадлежит: BioIncept LLC

A novel class of embryo derived peptides are described (Preimplantation factor) that were generated synthetically and were tested on peripheral blood immune cells and shown to block activated but not basal immunity, inhibiting cell proliferation and creating a T H 2 type cytokine bias, in addition PIF enhance endometrial receptivity by increasing adhesion molecules expression. PIF biological activity appears to be exerted by specific binding to inducible receptors present on the several white cell lineages. PIF peptides, which are immune modulators therefore may have diagnostic and non toxic therapeutic applications in improving fertility, reducing pregnancy loss as well may be useful when administered for the treatment of autoimmune diseases and for prevention xenotransplants rejection. Further, polyclonal antibodies against PIF peptides were generated that serve for precise measurements of PIF in biological fluids. They document pregnancy presence and viability as well it helps for monitoring pregnancies at risk in humans as well as in farm and non farm animals, improving animal husbandry, where currently no specific pregnancy test exists. Also the PIF antibodies may have additional therapeutic properties for treatment of HIV, and malaria.

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17-05-2012 дата публикации

Oxidation catalyst

Номер: US20120122660A1
Принадлежит: JOHNSON MATTHEY PLC

An oxidation catalyst comprises an extruded solid body comprising: 10-95% by weight of at least one binder/matrix component; 5-90% by weight of a zeolitic molecular sieve, a non-zeolitic molecular sieve or a mixture of any two or more thereof; and 0-80% by weight optionally stabilised ceria, which catalyst comprising at least one precious metal and optionally at least one non-precious metal, wherein: (i) a majority of the at least one precious metal is located at a surface of the extruded solid body; (ii) the at least one precious metal is carried in one or more coating layer(s) on a surface; (iii) at least one metal is present throughout the extruded solid body and in a higher concentration at a surface; (iv) at least one metal is present throughout the extruded solid body and in a coating layer(s) on a surface; or (v) a combination of (ii) and (iii).

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07-06-2012 дата публикации

Process for Producing Broader Molecular Weight Distribution Polymers with a Reverse Comonomer Distribution and Low Levels of Long Chain Branches

Номер: US20120141710A1
Принадлежит: Chevron Phillips Chemical Co LP

The present invention provides a polymerization process which is conducted by contacting an olefin monomer and at least one olefin comonomer in the presence of hydrogen and a metallocene-based catalyst composition. Polymers produced from the polymerization process are also provided, and these polymers have a reverse comonomer distribution, low levels of long chain branches, and a ratio of Mw/Mn from about 3 to about 6.

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07-06-2012 дата публикации

Borohydride Metallocene Complex of a Lanthanide, Catalytic System Including Said Complex, Polymerization Method Using Same and Ethylene/Butadiene Copolymer Obtained Using Said Method

Номер: US20120142905A1

Borohydride metallocene complex of lanthanide, preparation process, catalytic system incorporating borohydride metallocene complex, process for copolymerization of olefins employing catalytic system. The complex corresponds to one or other of formulae A and B: where, in A, two ligands Cp 1 , Cp 2 , each composed of a cyclopentadienyl group, are connected to the lanthanide Ln, such as Nd, and where, in B, a ligand molecule, composed of two cyclopentadienyl groups Cp 1 , Cp 2 connected to one another via a bridge P of formula MR 1 R 2 , M is an element from group IVa, and R 1 and R 2 , which are identical or different, represent an alkyl group comprising from 1 to 20 carbon atoms, is connected to the lanthanide Ln, L is alkali metal, N is molecule of a complexing solvent, x is integral or non-integral number≧0, p is integer≧than 1 and y is integer≧0.

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14-06-2012 дата публикации

System, Method And Apparatus For Enhancing Wellbore Treatment Fluid Flexibility

Номер: US20120145376A1
Принадлежит: Schlumberger Technology Corp

A method includes performing a chemical process to create a chemical product and an amount of heat, and transferring the heat to a first fluid. The method further includes hydrating a polymer in the first fluid, and adding the chemical product from the chemical process to the first fluid to create a treatment fluid. The method further includes diluting the treatment fluid with respect to at least one constituent of the treatment fluid. The method includes treating a formation of interest in a wellbore with the treatment fluid. The method includes changing a formulation of the treatment fluid during the treating. The method also includes extending the treating beyond a design amount, or ending the treatment before the design amount and preserving some reagents of the chemical process.

Подробнее
14-06-2012 дата публикации

Neisseria meningitidis antigens and compositions

Номер: US20120148616A1
Принадлежит: J Craig Venter Institute Inc, NOVARTIS AG

The invention provides proteins from Neisseria meningitidis , including the amino acid sequences and the corresponding nucleotide sequences. The proteins are predicted to be useful antigens for vaccines and/or diagnostics.

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14-06-2012 дата публикации

Composition and Method For Using Waxy Oil-External Emulsions To Modify Reservoir Permeability Profiles

Номер: US20120149605A1
Принадлежит: ExxonMobil Upstream Research Co

A waxy oil-external emulsion is provided for injection into a selected zone of a subsurface formation. The selected zone is typically a high permeability zone. The emulsion generally comprises oil, added wax, and water. The emulsion may also include an emulsifying agent and a solvent. The emulsion is formulated to be a liquid at a temperature greater than a targeted temperature in the subsurface formation, but a solid at the targeted temperature. The targeted temperature is typically the maximum operating temperature for the formation. A method of formulating the emulsion is also provided. Further, a method of plugging a high permeability zone using the emulsion is disclosed.

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21-06-2012 дата публикации

Mechanical locking of building panels

Номер: US20120151865A1
Автор: DARKO PERVAN, JAN PETERSON
Принадлежит: VALINGE INNOVATION AB

Building panels ( 1, 1 ′) are shown, which are provided with a mechanical locking system having tongue ( 30 ) of magnetic material that could be locked vertically by a magnetic field.

Подробнее
28-06-2012 дата публикации

Tape base for superconducting wire, and superconducting wire

Номер: US20120165199A1
Автор: Hiroyuki Fukushima
Принадлежит: Furukawa Electric Co Ltd

A tape-shaped base for a superconducting wire, which simplifies the intermediate layer and thus enables production of a superconducting wire at lower cost, and which is capable of improving the characteristics (such as electrical conduction and handling properties) of a superconducting wire; and a superconducting wire. Specifically disclosed is a tape-shaped base for a superconducting wire, which is obtained by forming an intermediate layer on a metal substrate. In the tape-shaped base for a superconducting wire a biaxially oriented layer of the intermediate layer is configured of a niobium monoxide (NbO) layer that is formed by depositing vapor deposition particles from a vapor deposition source on a film formation surface.

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05-07-2012 дата публикации

Element of a chain link of an energy guide chain, produced by means of a fluid internal pressure injection molding process

Номер: US20120167541A1
Принадлежит: KABELSCHLEPP GMBH

Component of a chain element of an energy-conducting chain, wherein the component has a cavity which is produced by means of a fluid internal pressure injection molding method, or is formed from a micro-cellular foam.

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19-07-2012 дата публикации

Superconducting Devices with Ferromagnetic Barrier Junctions

Номер: US20120184445A1
Принадлежит: Hypres Inc

A superconducting memory cell includes a magnetic Josephson junction (MJJ) with a ferromagnetic material, having at least two switchable states of magnetization. The binary state of the MJJ manifests itself as a pulse appearing, or not appearing, on the output. A superconducting memory includes an array of memory cells. Each memory cell includes a comparator with at least one MJJ. Selected X and Y-directional write lines in their combination are capable of switching the magnetization of the MJJ. A superconducting device includes a first and a second junction in a stacked configuration. The first junction has an insulating layer barrier, and the second junction has an insulating layer sandwiched in-between two ferromagnetic layers as barrier. An electrical signal inputted across the first junction is amplified across the second junction.

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19-07-2012 дата публикации

Apparatus for Separation of Constituents From Matrices

Номер: US20120184795A1
Автор: Jeffrey K. O'Ham
Принадлежит: IR Systems International

The present invention provides an apparatus useful for the separation of hazardous and non-hazardous organic and inorganic constituents from various matrices. A method of separating such constituents is also provided.

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26-07-2012 дата публикации

Treatment and prophylaxis of amyloidosis

Номер: US20120189624A1
Принадлежит: Elan Pharmaceuticals LLC

Methods useful for effecting prophylaxis or treatment of amyloidosis, including AA Amyloidosis and AL amyloidosis, by administering peptides comprising neoepitopes, such as AA fragments from a C-terminal region of AA, and antibodies specific for neoepitopes of aggregated amyloid proteins, for example, antibodies specific for the C-terminal region of AA fibrils. Antibodies for inhibition of formation and/or increasing clearance of amyloid deposits in a patient thus effecting prophylaxis or treating amyloid disease.

Подробнее
02-08-2012 дата публикации

Degradable heterobifunctional poly(ethylene glycol) acrylates and gels and conjugates derived therefrom

Номер: US20120195846A1
Принадлежит: Nektar Therapeutics AL Corp

A heterobifunctional poly(ethylene glycol) is provided having a hydrolytically degradable linkage, a first terminus comprising an acrylate group, and a second terminus comprising a target such as a protein or pharmaceutical agent or a reactive moiety capable of coupling to a target. Hydrogels can be prepared. The hydrogels can be used as a carrier for a protein or a pharmaceutical agent that can be readily released in a controlled fashion.

Подробнее
02-08-2012 дата публикации

Method for producing copolymer

Номер: US20120196993A1
Принадлежит: Bridgestone Corp

This invention relates to a method for producing a copolymer of a conjugated diene compound and an unconjugated olefin other than the conjugated diene compound having a high cis-1,4 bond content of a conjugated diene compound portion, and more particularly to a method for producing a copolymer characterized by comprising a step of polymerizing a conjugated diene compound and an unconjugated olefin other than the conjugated diene compound in the presence of a polymerization catalyst composition including at least one complex selected from a metallocene complex represented by the following general formula (I): (wherein M is a lanthanoid element, scandium, or yttrium, and Cp R is independently a non-substituted or substituted indenyl, and R a -R f are independently an alkyl group having a carbon number of 1-3 or a hydrogen atom, and L is a neutral Lewis base, and w is an integer of 0-3) and so on.

Подробнее
09-08-2012 дата публикации

Halogen Substituted Heteroatom-Containing Metallocene Compounds for Olefin Polymerization

Номер: US20120202956A1
Принадлежит: ExxonMobil Chemical Patents Inc

Halogen substituted metallocene compounds are described and comprise one or more monocyclic or polycyclic ligands that are pi-bonded to the metal atom and include at least one halogen substituent directly bonded to an sp 2 carbon atom at a bondable ring position of the ligand, wherein the or at least one ligand has one or more ring heteroatoms in its cyclic structure. When combined with a suitable activator, these compounds show activity in the polymerization of olefins, such as ethylene and propylene.

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23-08-2012 дата публикации

Doxorubicin immunoassay

Номер: US20120214184A1
Принадлежит: Individual

Novel conjugates of doxorubicin and novel doxorubicin immunogens derived from the 13 and 14 positions of doxorubicin and antibodies generated by these doxorubicin linked immunogens all of which are useful in immunoassays for the quantification and monitoring of doxorubicin in biological fluids.

Подробнее
27-09-2012 дата публикации

Polyolefins Prepared from a Metallocene and a New Single Site Catalyst Components in a Single Reactor

Номер: US20120245021A1
Автор: Abbas Razavi
Принадлежит: Total Petrochemicals Research Feluy SA

The present invention discloses a catalyst system based on a metallocene catalyst component and a new single site catalyst component for the production in a single reactor of improved polyolefins having a bimodal molecular weight distribution.

Подробнее
04-10-2012 дата публикации

Method and apparatus to treat well stimulation fluids in-situ

Номер: US20120247758A1
Автор: David R. Smith
Принадлежит: Individual

A method and apparatus for the management of injection and production of well fluids in a subterranean well is described to optimize the use of stimulation fluids to enhance their compatibility with subterranean reservoirs and the surface environment and thereby reducing the damage said fluids induce in subterranean reservoirs and upon flow back to the surface reduce their damage to the environment is described. More specifically, this method is directed to the subterranean treatment of injection fluids.

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25-10-2012 дата публикации

Catalysts

Номер: US20120271016A1
Принадлежит: Oxford University Innovation Ltd

The present invention relates to novel metallocene catalysts of formula I, which is defined herein. The present invention also provides processes for making these catalysts and their use in olefin polymerisation reactions.

Подробнее
22-11-2012 дата публикации

Reticulated stereo building block for construction of buildings and its procedure

Номер: US20120291365A1
Принадлежит: BEUCHAT BARROS AND PFENNIGER

The invention relates to the construction of buildings, especially a reticulated stereo modular element that, combined with other identical elements, enables the construction of quadrangular enclosures suitable for the construction of rooms.

Подробнее
22-11-2012 дата публикации

Methods And System For Ash Detection In Exhaust Particulate Filter

Номер: US20120291419A1
Принадлежит: Caterpillar Inc

A method of detecting ash in an exhaust particulate filter system for an internal combustion engine includes transmitting electromagnetic energy through an exhaust particulate filter containing soot and ash, and sensing a strength of the transmitted electromagnetic energy after having been attenuated in response to the soot. The method further includes electronically storing a filter monitoring history responsive to a difference between the transmitted strength and the sensed strength of the electromagnetic energy, and detecting an amount of the ash based at least in part upon a pattern of electromagnetic energy attenuation defined by the stored filter monitoring history. An exhaust particulate filter system for implementing related methodology includes a microprocessor configured to determine a value indicative of an amount of ash contained within an exhaust particulate filter responsive to a pattern of electromagnetic energy attenuation defined by a stored filter monitoring history.

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22-11-2012 дата публикации

Process for toluene and methane coupling in a microreactor

Номер: US20120296133A1
Автор: James R. Butler
Принадлежит: Fina Technology Inc

A process for making ethylbenzene and/or styrene by reacting toluene with methane in one or more microreactors is disclosed. In one embodiment a method of revamping an existing styrene production facility by adding one or more microreactors capable of reacting toluene with methane to produce a product stream comprising ethylbenzene and/or styrene is disclosed.

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13-12-2012 дата публикации

Modified phosphinimine catalysts for olefin polymerization

Номер: US20120316297A1
Принадлежит: Nova Chemicals International SA

Olefin polymerization is carried out with a supported phosphinimine catalyst which has been treated with a long chain substituted amine compound.

Подробнее
20-12-2012 дата публикации

Treatment and prophylaxis of amyloidosis

Номер: US20120321555A1

Methods useful for effecting prophylaxis or treatment of amyloidosis, including AA Amyloidosis and AL amyloidosis, by administering peptides comprising neoepitopes, such as AA fragments from a C-terminal region of AA, and antibodies specific for neoepitopes of aggregated amyloid proteins, for example, antibodies specific for the C-terminal region of AA fibrils. Antibodies for inhibition of formation and/or increasing clearance of amyloid deposits in a patient thus effecting prophylaxis or treating amyloid disease.

Подробнее
31-01-2013 дата публикации

Fluid Filtration Medium

Номер: US20130026103A1
Принадлежит: Zeotech Corp

The present application relates to improved filtration of fluids. Particularly, a surfactant-treated zeolite material may be utilized for removing turbid particles from a volume of fluid, such as water.

Подробнее
07-02-2013 дата публикации

Device for filling soluble containers with an improved assembly for orienting and filling capsules

Номер: US20130032246A1
Принадлежит: Raj Vikram Tahil

A device for filling soluble containers is provided. The device includes an assembly for orienting capsules comprising a sheet component having a top sheet, a bottom sheet and a sliding sheet adapted to move between the top and bottom sheets. The top sheet includes slots for accommodating capsules, and the bottom sheet includes notches adapted to orient the capsules into a filling position. In a first position, the slots in the sliding sheet align with the slots in the top sheet. In a second position, the slots in the sliding sheet align with the notches in the bottom sheet. The assembly also includes a base component for guiding the oriented capsules therethrough. The base component can have an antistatic sheet fastened to the bottom surface. The sheet component can be loose fitted to the base component. An assembly for filling capsules is also provided.

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07-02-2013 дата публикации

High Activity Catalyst Compositions Containing Silicon-Bridged Metallocenes with Bulky Substituents

Номер: US20130035458A1
Принадлежит: Chevron Phillips Chemical Co LP

The present invention discloses catalyst compositions employing silicon-bridged metallocene compounds with bulky substituents. Methods for making these silicon-bridged metallocene compounds and for using such compounds in catalyst compositions for the polymerization of olefins also are provided.

Подробнее
14-02-2013 дата публикации

Vacuum Cleaner Filter Bag Having a Side Fold

Номер: US20130036717A1
Автор: Jan Schultink, Ralf Sauer
Принадлежит: Eurofilters Holding NV

The invention comprises a vacuum cleaner filter bag having at least one side fold formed by two fold legs, wherein the vacuum cleaner filter bag is designed as a tubular bag, wherein, in a turned-in state, the at least one side fold has at least three edges, wherein two of the edges are formed by a respective weld seam, and wherein the side fold can be turned out with the edges formed by a weld seam.

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14-02-2013 дата публикации

Drag reduction of asphaltenic crude oils

Номер: US20130037117A1
Принадлежит: ConocoPhillips Co

A method of introducing a drag reducing polymer into a pipeline such that the friction loss associated with the turbulent flow though the pipeline is reduced by suppressing the growth of turbulent eddies. The drag reducing polymer is introduced into a liquid hydrocarbon having an asphaltene content of at least 3 weight percent and an API gravity of less than about 26° to thereby produce a treated liquid hydrocarbon. The treated liquid hydrocarbon does not have a viscosity less than the viscosity of the liquid hydrocarbon prior to treatment with the drag reducing polymer. Additionally, the drag reducing polymer is added to the liquid hydrocarbon in the range from about 0.1 to about 500 ppmw.

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14-02-2013 дата публикации

Drag reduction of asphaltenic crude oils

Номер: US20130041094A1
Принадлежит: ConocoPhillips Co

A method of preparing a drag reducing polymer wherein the drag reducing polymer is able to be injected into a pipeline, such that the friction loss associated with the turbulent flow through the pipeline is reduced by suppressing the growth of turbulent eddies. The drag reducing polymer is injected into a pipeline of liquid hydrocarbon hydrocarbon having an asphaltene content of at least 3 weight percent and an API gravity of less than about 26° to thereby produce a treated liquid hydrocarbon wherein the viscosity of the treated liquid hydrocarbon is not less than the viscosity of the liquid hydrocarbon prior to treatment with the drag reducing polymer. The drag reducing polymer has a solubility parameter within 4 MPa 1/2 of the solubility parameter of the liquid hydrocarbon. The drag reducing polymer is also added to the liquid hydrocarbon in the range from about 0.1 to about 500 ppmw.

Подробнее
28-02-2013 дата публикации

Semi continuous process for the synthesis of a catalyst for use in the manufacture of polyolefins

Номер: US20130053521A1
Принадлежит: Reliance Industries Ltd

A semi-continuous process and system thereof, for the synthesis of a narrow particle size distribution Zeigler Natta procatalyst for use in the manufacture of polyolefins. The process comprises: (a) mixing a reaction mixture containing a titanium compound; (b) charging a first reactor with said reaction mixture; (c) removing excess reactants from said first reactor as a filtrate; (d) feeding said filtrate to at least one further reactor; and continuously removing excess reactants from said at least further reactor.

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28-02-2013 дата публикации

Polymerization Process for Producing Bimodal Polymers

Номер: US20130053523A1
Принадлежит: Chevron Phillips Chemical Co LP

Catalyst compositions comprising a first metallocene compound, a second metallocene compound, an activator-support, and an organoaluminum compound are provided. An improved method for preparing cyclopentadienyl complexes used to produce polyolefins is also provided.

Подробнее
07-03-2013 дата публикации

METHODS FOR IMPROVING THE BIOACTIVITY OF THERAPEUTIC IgE ANTIBODIES FOR THE TREATMENT OF DISEASE

Номер: US20130058920A1
Принадлежит: Advanced Immune Therapeutics Inc

The invention provides a method for increasing the bioactivity (e.g. the biosafety and efficacy) of a therapeutic IgE antibody of the invention in the treatment of a patient. Methods of the invention include: i) administering to the patient a therapeutic IgE antibody in combination with at least one bioactivity-enhancing agent, ii) strategic treatment regimens and protocols for the dosing and administration of a therapeutic IgE antibody of the invention, and iii) the use of a therapeutic IgE antibody having a variable region comprising at least one antigen binding region specific for binding an epitope of an antigen wherein the epitope is not highly repetitive or is non-repetitive.

Подробнее
14-03-2013 дата публикации

Powder coating booth

Номер: US20130061886A1
Принадлежит: Nordson Corp

A powder spray for lengthy parts includes a booth wall structure comprised primarily of doors. A moveable roof may be raised and lowered to clean powder overspray from the interior surfaces of the booth. A cleaning process may be performed with a sideways extraction mode and a downward extraction mode. The mode change occurs when a bulkhead that travels with the moveable roof blocks the inlet duct to the recovery system. The recovery system may be a cyclone system for example. The doors of the booth are hinged so that they can be positioned for spraying operations and cleaning operations. Live hinge designs are provided and hose stress relief designs are also provided. The roof may carry accumulators for pressurized air that feed cleaning nozzles as the roof descends. In addition, exhaust air may be used to assist cleaning the interior surfaces as the roof descends. All of the energy provided for cleaning and color change may be provided by accumulators.

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14-03-2013 дата публикации

Engineered anti-il-23r antibodies

Номер: US20130064817A1
Автор: Leonard G. Presta
Принадлежит: Merck Sharp and Dohme LLC

Antibodies to human IL-23R are provided, as well as uses thereof, e.g. in treatment of inflammatory, autoimmune, and proliferative disorders.

Подробнее
21-03-2013 дата публикации

ELECTROSPUN CACTUS MUCILAGE NANOFIBERS

Номер: US20130068692A1
Принадлежит: UNIVERSITY OF SOUTH FLORIDA

Novel electrospun nanofibers and nanofibrous membranes, methods of manufacturing the same, and methods of using the same are provided. The nanofibers include a cactus mucilage, such as mucilage from . An organic polymer can be added to the cactus mucilage before electrospinning The nanofibrous membranes can be used in water filtration. 1. An electrospun nanofiber , comprising a cactus mucilage.2Opuntia ficus-indica. The electrospun nanofiber according to claim 1 , wherein the cactus mucilage is (Ofi) mucilage.3. The electrospun nanofiber according to claim 2 , further comprising an organic polymer.4. The electrospun nanofiber according to claim 3 , wherein the organic polymer is polyvinyl alcohol (PVA).5. The electrospun nanofiber according to claim 1 , further comprising an organic polymer claim 1 , wherein the organic polymer is PVA claim 1 , chitosan claim 1 , polyethylene glycol (PEG) claim 1 , or poly lactic acid (PLA).6. A nanofibrous membrane claim 1 , comprising at least one electrospun nanofiber according to .7. The nanofibrous membrane according to claim 6 , wherein the cactus mucilage is Ofi mucilage.8. The nanofibrous membrane according to claim 6 , wherein the at least one electrospun nanofiber further comprises an organic polymer claim 6 , wherein the organic polymer is PVA claim 6 , chitosan claim 6 , PEG claim 6 , or PLA.9. A method of producing an electrospun nanofiber claim 6 , comprising:forming an electrospinning solution comprising a cactus mucilage and an organic polymer; andelectrospinning the electrospinning solution to form the electrospun nanofibril.10. The method according to claim 9 , wherein forming the electrospinning solution comprises:dissolving the cactus mucilage in a first solvent to form a first solution;dissolving the organic polymer in a second solvent to form a second solution; andcombining the second solution and the first solution to form the electrospinning solution.11Opuntia ficus-indica. The method according to claim 9 , ...

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11-04-2013 дата публикации

Supporting and Guiding Device for Feeding Lines for Digging Tools

Номер: US20130087646A1
Автор: Davide Trevisani
Принадлежит: Soilmec SpA

A device for supporting and guiding supplying lines used with a digging tool on a drilling machine is described. The device comprises a support branch, formed by a plurality of spacers, adjacent to one another in which a rope or tie-rod is inserted in a housing comprised in the spacers, a supplying pipe for the supplying line and a crosspiece comprising a seat adapted to support the supplying pipe. Each pair of adjacent spacers comprises retaining means. Each retaining means comprises a retaining element, associated to a first spacer of a pair of adjacent spacers, and a slot having a shape substantially matching the shape of the retaining element, associated to a second spacer of the pair of adjacent spacers. A retaining element, during use, engages with a slot allowing relative axial movement, in the longitudinal direction of the rope, of a predetermined amount.

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18-04-2013 дата публикации

Ethylene-based terpolymer having high elasticity and preparation method thereof

Номер: US20130096269A1

The present invention relates to an ethylene-based terpolymer having high elasticity and a preparation method thereof, and more particularly, to a highly elastic, ethylene-based terpolymer, which comprises a specific molar ratio of a ethylene unit, a C 6-12 α-olefin unit and at least one functional unit selected from the group consisting of divinylbenzene and para-methylstyrene and to a method of preparing the highly elastic, ethylene-based terpolymer using a metallocene catalyst.

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25-04-2013 дата публикации

Method of forming filter arrangements; and, apparatus

Номер: US20130097980A1
Автор: Benny Kevin Nelson
Принадлежит: Donaldson Co Inc

In one aspect a method of forming filter cartridge arrangements for use in air cleaners is provided. The method involves coiling a media pack with a central winding bead and cutting through the winding bead in the coiled media pack to form two media packs. An example filter arrangement is disclosed. In another aspect, a filter cartridge arrangement for use in air cleaners is provided. The filter cartridge arrangement includes a media pack including a plurality of inlet flutes and outlet flutes extending between first and second opposite flow faces and formed from an arrangement of facing sheet secured to corrugated sheet. An example cartridge includes a preform secured to the media pack.

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02-05-2013 дата публикации

Radioactive-substance-absorbent, radioactive-substance-absorbent production device, decontaminating method, and bag unit

Номер: US20130109902A1
Автор: Masao Yamada
Принадлежит: Seibu Newsaper Co

By fibrillated cellulose fibrillated in fiber form and humidified as a water permeable polymeric substance of botanical origin and a radioactive-substance-absorbent obtained by mixing with zeolite as a granulated inorganic porous crystal, radioactive substances released and spilled in a accident etc. in a nuclear facility etc. may be efficiently and easily collected and removed at a low cost.

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16-05-2013 дата публикации

Method for producing a water-absorbent resin

Номер: US20130123455A1
Принадлежит: Sumitomo Seika Chemicals Co Ltd

A method for producing a water-absorbent resin having a further reduced odor as compared with a water-absorbent resin obtained by a conventional method as well as a water-absorbent resin produced by the same method, by maintaining the addition rate V from the pouring nozzle for the aqueous solution of the water-soluble ethylenically unsaturated monomer in a polymerization reaction tank not more than 0.30 [min −1 ], in the first stage polymerization step which is within the step of the conventional method upon performing multi-stages such as two or more stages of reversed-phase suspension polymerizations in a method for producing a water-absorbent resin, and thereby by being able to reduce the amount of the petroleum hydrocarbon dispersion medium remaining in the above water-absorbent resin.

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23-05-2013 дата публикации

Ti catalyst systems comprising substituted cyclopentadienyl, amidine and diene ligand

Номер: US20130131296A1
Принадлежит: Lanxess Elastomers BV

The invention relates to a catalyst system for the polymerization of olefins comprising a metal complex of formula CyLMD and an activating cocatalyst, wherein M is titanium, Cy is a cyclopentadienyl-type ligand, D is a diene, L is an amidinate-containing ligand of formula (1), wherein the amidinate-containing ligand is covalently bonded to the titanium via the imine nitrogen atom, Sub 1 is a substituent, which comprises a group 14 atom through which Sub 1 is bonded to the imine carbon atom, Sub 2 is a substituent, which comprises a nitrogen atom, through which Sub 2 is bonded to the imine carbon atom, and Cy is a mono- or polysubstituted cyclopentadienyl-type ligand, wherein the one or more substituents of Cy are selected from the group consisting of halogen, hydrocarbyl, silyl and germyl residues, optionally substituted with one or more halogen, amido, phosphido, alkoxy, or aryloxy residues. The invention further relates to a process for the preparation of a polymer comprising at least one aliphatic or aromatic hydrocarbyl C 2-20 olefin wherein the at least one aliphatic or aromatic olefin is contacted with the catalyst system of the present invention.

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13-06-2013 дата публикации

Flame Resistant Filler Cloth and Mattresses Incorporating Same

Номер: US20130149518A1
Принадлежит: Precision Fabrics Group Inc

A filler cloth includes cellulosic fibers treated with a flame retardant chemistry such that the filler cloth has a char length of less than about nine inches when tested in accordance with NFPA 701, such that thermal shrinkage of the filler cloth at 400° F. is less than about 35% in any direction, and such that the filler cloth maintains flame and heat resistant integrity when impinged with a gas flame in accordance with testing protocols set forth in Technical Bulletin 603 of the State of California Department of Consumer Affairs. The filler cloth cellulosic fibers are treated with a flame retardant chemistry such that the filler cloth has a Frazier air permeability of less than about 400 cfm and a thermal resistance rating of at least about 3 when tested according to NFPA 2112.

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20-06-2013 дата публикации

Porin B (PorB) as a Therapeutic Target for Prevention and Treatment of Infection by Chlamydia

Номер: US20130156804A1
Принадлежит: UNIVERSITY OF CALIFORNIA

The present invention features peptides of a PorB polypeptide, which PorB peptides are useful in production of antibodies that bind the full-length PorB polypeptide and as a therapeutic agent. In specific embodiments the invention features a composition comprising one or more PorB peptides (other than a full-length PorB polypeptide), which peptides contain at least one epitope that can elicit Chlamydia -neutralizing antibodies. The invention also features methods for induction of a protective immune response against infection by Chlamydia and Chlamydiophila.

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27-06-2013 дата публикации

Compositions and methods for screening for lyme disease

Номер: US20130164759A1

The invention provides compositions, methods, and kits for the diagnosis or detection of infection by a pathogen that causes Lyme disease in a subject.

Подробнее
18-07-2013 дата публикации

Light-Activated Cation Channel and Uses Thereof

Номер: US20130184817A1
Принадлежит: Leland Stanford Junior University

The present invention provides compositions and methods for light-activated cation channel proteins and their uses within cell membranes and subcellular regions. The invention provides for proteins, nucleic acids, vectors and methods for genetically targeted expression of light-activated cation channels to specific cells or defined cell populations. In particular the invention provides millisecond-timescale temporal control of cation channels using moderate light intensities in cells, cell lines, transgenic animals, and humans. The invention provides for optically generating electrical spikes in nerve cells and other excitable cells useful for driving neuronal networks, drug screening, and therapy.

Подробнее
25-07-2013 дата публикации

Polymer particles having polymer brush and method of preparing the same

Номер: US20130190455A1
Принадлежит: LG Chem Ltd

The present invention provides a method of preparing a polymer particle. More precisely, the invention provides a polymer particle having optimum impact strength and improved elastic recovery rate by forming the brush having softness on the surface of the monodisperse polymer particle by the anion dispersion polymerization using a conjugated diene monomer.

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08-08-2013 дата публикации

System and method for coupling and sealing filters

Номер: US20130199140A1
Принадлежит: ADVANCED FILTRATION PRODUCTS LLC

In some embodiments, an air filter coupling device may include an elongated member, an elongated first cap, and an elongated second cap. The elongated member may include a substantially planar first side, a substantially planar second side positioned substantially opposite the first side, and a fourth side positioned substantially opposite the third side. In some embodiments, the elongated first cap may be coupled to the third side in a substantially orthogonal orientation relative to the elongated member. In some embodiments, the elongated second cap may be coupled to the fourth side in a substantially orthogonal orientation relative to the elongated member. A second distance between the first cap and the second cap adjacent each first end portion of the first and second caps inhibits removal of the first air filter. The air filter coupling device inhibits conveyance of materials between the first air filter and the second air filter.

Подробнее
15-08-2013 дата публикации

Fischer-tropsch catalyst regeneration

Номер: US20130210939A1
Принадлежит: GTL F1 AG

A process for the regeneration of deactivated catalyst from a Fischer-Tropsch synthesis reactor, the catalyst being a supported cobalt catalyst. The process comprises the following steps: a withdrawal step, in which a portion of deactivated catalyst together with liquid hydrocarbon is withdrawn from the reactor; a concentration step, in which the concentration of the catalyst in the liquid hydrocarbon is increased; a calcination step, in which the deactivated catalyst composition is subjected to an oxidising gas to oxidise carbonaceous material contained in the deactivated catalyst in to gaseous oxides of the components of the carbonaceous material; and a reactivation step, in which the deactivated catalyst composition is reactivated to produced a regenerated catalyst.

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15-08-2013 дата публикации

Method for preparing polypropylene using transition metal compound containing thiophene-fused cyclopentadienyl ligand

Номер: US20130211021A1
Принадлежит: Lotte Chemical Corp

The present invention relates to a preparation method for polypropylene that comprises polymerizing a propylene monomer in the presence of a catalyst comprising a novel transition metal compound. Using the novel transition metal compound as a catalyst, the preparation method for polypropylene according to the present invention can not only acquire high catalytic activity for polymerization to achieve high efficiency of the process but allow it to easily control the fine-structure characteristics of the polymer, thereby providing polypropylene having desired properties with ease.

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22-08-2013 дата публикации

Cable protection and guide device

Номер: US20130212997A1
Автор: Shoichiro Komiya
Принадлежит: Tsubakimoto Chain Co

A cable protection and guide device capable of preventing abrasion powder that is otherwise generated when a link side plate slides on a support surface while switching between a linear position and a flexional position. The link side plate integrally includes: a front side plate portion connected to a longitudinally preceding link side plate to form a cable flexional inner circumferential side; a rear side plate portion connected to a longitudinally succeeding link side plate to form a cable flexional outer circumferential side; and, a flexible linkage portion interposed between the front and rear side plate portions. The rear side plate portion includes a first flexional outer circumferential end surface in an arc shape and provided on the cable flexional outer circumferential side, and, an arc center of the first flexional outer circumferential end surface longitudinally preceding a center of the linkage portion of the succeeding link side plate.

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22-08-2013 дата публикации

Process for olefin polymerisation using group 4 metallocene as catalysts

Номер: US20130217845A1
Принадлежит: Borealis AG

A process for the preparation of a random propylene copolymer comprising polymerising propylene and at least one C2-10 alpha olefin (especially ethylene) in the presence of a catalyst; wherein said catalyst comprises: (i) a complex of formula (I): wherein M is zirconium or hafnium; each X is a sigma ligand; L is a divalent bridge selected from —R′ 2 C—, —R′ 2 C—CR′ 2 —, —R′ 2 Si—, —R′ 2 Si—SiR 2 —, —R′ 2 Ge—, wherein each R′ is independently a hydrogen atom, C1-C20-hydrocarbyl, tri(C1-C20-alkyl)silyl, C6-C20-aryl, C7-C20-arylalkyl or C7-C20-alkylaryl; each R 1 is a C4-C20 hydrocarbyl radical branched at the β-atom to the cyclopentadienyl ring, optionally containing one or more heteroatoms belonging to groups 14-16, or is a C3-C20 hydrocarbyl radical branched at the β-atom to the cyclopentadienyl ring where the β-atom is an Si-atom; n is 0-3; each R 18 is the same or different and may be a C1-C20 hydrocarbyl radical optionally containing one or more heteroatoms belonging to groups 14-16; each R 4 is a hydrogen atom or a C1-6-hydrocarbyl radical; each W is a 5 or 6 membered aryl or heteroaryl ring wherein each atom of said ring is optionally substituted with an R 5 group; each R 5 is the same or different and is a C1-C20 hydrocarbyl radical optionally containing one or more heteroatoms belonging to groups 14-16; and optionally two adjacent R 5 groups taken together can form a further mono or multicyclic ring condensed to W optionally substituted by one or two groups R 5 ; and (ii) a cocatalyst comprising an organometallic compound of a Group 13 metal.

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29-08-2013 дата публикации

Catalyst for selective oxidation of nh3 to n2 and method for preparing the same

Номер: US20130224090A1
Принадлежит: SK Innovation Co Ltd

Disclosed is a catalyst which can convert ammonia contained in exhaust gas from an engine of a vehicle equipped with a Urea-SCR (Urea-Selective Catalytic Reduction) system, to nitrogen, and a method for preparating the same. The catalyst can convert ammonia which is failed to participate in a conversion reaction of NOx to N2 and slipped out of the SCR catalyst, to nitrogen via a SCO (Selective Catalytic Oxidation) reaction, before the ammonia is released to the air.

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29-08-2013 дата публикации

Cyclopenta[b]Fluorenyl Transition Metal Compound, Catalyst Composition Containing the Same, and Method of Preparing Ethylene Homopolymer or Copolymer of Ethylene and alpha-Olefin Using the Same

Номер: US20130225834A1

The present invention relates to a new transition metal compound based on cyclopenta[b]fluorenyl group, a transition metal catalyst composition containing the same and having high catalytic activity for preparing an ethylene homopolymer or a copolymer of ethylene and one α-olefin, a method of preparing an ethylene homopolymer or a copolymer of ethylene and α-olefin using the same, and the prepared ethylene homopolymer or the copolymer of ethylene and α-olefin.

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12-09-2013 дата публикации

System and process for inhibitor injection

Номер: US20130233544A1
Принадлежит: HRD Corp

A method for introducing inhibitor into a fluid to be treated by forming a dispersion comprising droplets, particles, or gas bubbles of inhibitor dispersed in a continuous phase of a carrier, wherein forming the dispersion comprises subjecting a mixture of the inhibitor and the carrier to a shear rate of greater than about 20,000 s −1 in a high shear device comprising at least one generator comprising a rotor and a complementarily-shaped stator, wherein the rotor and the stator each comprise grooves, and wherein the grooves of the stator and the grooves of the rotor of each generator are disposed in alternating directions, and using at least a portion of the dispersion to inhibit corrosion.

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12-09-2013 дата публикации

Neodymium-catalyzed polybutadienes

Номер: US20130237669A1
Принадлежит: LANXESS DEUTSCHLAND GMBH

The invention relates to a high-molecular-weight, linear, neodymium-catalysed polybutadiene having a high proportion, >95%, of cis-1,4 units having a low proportion, <1%, of 1,2-vinyl content, and also having a small molar-mass-polydispersity index (MPI), characterized in that Mooney viscosity (ML 1+4 100° C.) of the polybutadiene is from 70 to 90 and The molar-mass-polydispersity index of the polybutadiene is smaller than 10.

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12-09-2013 дата публикации

Advanced transition metal catalytic systems in terms of comonomer incorporations and methods for preparing ethylene homopolymers or copolymers of ethylene and alpha-olefins using the same

Номер: US20130237674A1
Принадлежит: SK Innovation Co Ltd

Provided is a homogeneous catalytic system for use in preparing an ethylene homopolymer or a copolymer of ethylene and α-olefin, and more particularly a Group 4 transition metal compound in which a cyclopentadienyl derivative 3,4-positions of which are substituted with alkyls and an electron-donating substituent are crosslinked around a Group 4 transition metal. Also provided is a method of preparing an ethylene homopolymer or a copolymer of ethylene and α-olefin, having high molecular weight, under high-temperature solution polymerization conditions using the catalytic system including such a transition metal compound and a co-catalyst composed of an aluminum compound, a boron compound or a mixture thereof. The catalyst according to present invention has high thermal stability and enables the incorporation of α-olefin, and is thus effective in preparing an ethylene homopolymer or a copolymer of ethylene and α-olefin, having various properties, in industrial polymerization processes.

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26-09-2013 дата публикации

Shear reducing mattress cover

Номер: US20130247304A1
Принадлежит: SPAN-AMERICA MEDICAL SYSTEMS, INC.

A mattress cover is disclosed for redirecting shear on a patient's skin away from the areas of the body relatively more likely to develop decubitus ulcers. The mattress cover includes an upper portion designed to cover the topside of a mattress, and at least one shear transfer zone attached to an underside of the upper portion of the mattress cover. The shear transfer zone(s) may be made of a low shear material so as to create a low friction interface between the mattress and the mattress cover to reduce shear forces exerted by the mattress. Additionally, the shear transfer zone(s) may be arranged such that a large portion of the shear forces exerted by the mattress can be redirected to areas of the body that are relatively less likely to develop decubitus ulcers.

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24-10-2013 дата публикации

Polypeptides and Immunizing Compositions Containing Gram Positive Polypeptides and Methods of Use

Номер: US20130280300A1
Принадлежит: Epitopix LLC

The present invention provides isolated polypeptides isolatable from a Staphylococcus spp. Also provided by the present invention are compositions that include one or more of the polypeptides, and methods for making and methods for using the polypeptides.

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24-10-2013 дата публикации

Agents for treating disorders involving modulation of ryanodine receptors

Номер: US20130281512A1
Принадлежит: Armgo Pharma Inc, Laboratoires Servier SAS

The present invention relates to 1,4-benzothiazepine derivatives and their use to treat conditions, disorders and diseases associated with ryanodine receptors (RyRs) that regulate calcium channel functioning in cells. The invention also discloses pharmaceutical compositions comprising the compounds and uses thereof to treat diseases and conditions associated with RyRs, in particular cardiac, musculoskeletal and central nervous system (CNS) disorders.

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24-10-2013 дата публикации

New impact modifier and impact modified thermoplastic composition

Номер: US20130281629A1
Принадлежит: Arkema France SA

The invention relates to an impact modified thermoplastic resin comprising a polymeric impact modifier with a core-shell structure comprising 2-octylacrylate.

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31-10-2013 дата публикации

Polypeptides and Immunizing Compositions Containing Gram Positive Polypeptides and Methods of Use

Номер: US20130287813A1
Принадлежит: Epitopix LLC

The present invention provides isolated polypeptides isolatable from a Staphylococcus spp. Also provided by the present invention are compositions that include one or more of the polypeptides, and methods for making and methods for using the polypeptides.

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31-10-2013 дата публикации

Polynucleotides encoding antibodies that bind both il-17a and il-17f

Номер: US20130288304A1
Принадлежит: Zymogenetics Inc

The present invention relates to blocking, inhibiting, reducing, antagonizing or neutralizing the activity of IL-17A and IL-17F. IL-17A and IL-17F are cytokines that are involved in inflammatory processes and human disease. The present invention includes antibodies that bind both IL-17A and IL-17F, hybridomas that produce the antibodies, and methods of using the same in inflammation.

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31-10-2013 дата публикации

Polyethylene and Process for Production Thereof

Номер: US20130289213A1
Принадлежит: ExxonMobil Chemical Patents Inc

This invention relates to a process for polymerizing olefins in which the amount of trimethylaluminum in a methylalumoxane solution is adjusted to be from 1 to 25 mol %, prior to use as an activator, where the mol % trimethylaluminum is determined by 1 H NMR of the solution prior to combination with any support. This invention also relates to a process for polymerizing olefins in which the amount of an unknown species present in a methylalumoxane solution is adjusted to be from 0.10 to 0.65 integration units prior to use as an activator, where the amount of the unknown species is determined by the 1 H NMR spectra of the solution performed prior to combination with any support. Preferably, the methylalumoxane solution is present in a catalyst system also comprising a metallocene transition metal compound.

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14-11-2013 дата публикации

Anti-c epsilon mx antibodies capable of binding to human mige on b lymphocytes

Номер: US20130302314A1
Принадлежит: Academia Sinica

The invention pertains to the generation and utility of antibodies that can bind effectively to CεmX domain on membrane-bound IgE (mIgE) expressed on the surface of human B lymphocytes. The CεmX domain of 52 amino acid residues, located between the CH4 domain and the C-terminal membrane-anchor peptide on human membrane-bound epsilon chain, had been suggested as an antigenic site for immunological targeting of B cells expressing mIgE. Previous reported monoclonal antibodies, including a20, which bind to RADWPGPP (SEQ ID NO:1) peptide at the C-terminal of CεmX, have now been found to bind poorly to mIgE on human B cells. We have discovered that only monoclonal antibodies specific for certain segments, such as GLAGGSAQSQRAPDRVL (SEQ ID NO:2) and HSGQQQGLPRAAGGSVPHPR (SEQ ID NO:3), of CεmX can bind effectively to mIgE on human B cells and hence have the utility for targeting those B cells for the treatment of diseases mediated by IgE.

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21-11-2013 дата публикации

CD33 Antibodies And Use Of Same To Treat Cancer

Номер: US20130309223A1
Принадлежит: Seattle Genetics Inc

The invention provides murine, chimeric, and humanized antibodies that specifically bind to CD33. The antibodies are useful for treatment and diagnoses of various cancers as well as detecting CD33.

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21-11-2013 дата публикации

Expanded polypropylene resin particles, and polypropylene resin in-mold-expanded molding

Номер: US20130310476A1
Автор: Kenichi Senda
Принадлежит: Kaneka Corp

Polypropylene resin expanded particles comprising: a polypropylene resin as a base material resin, the propylene resin having at least two melting peaks on a DSC curve for a second temperature rise measured at a heating rate of 10 g/min with use of a heat flux differential scanning calorimeter (DSC), the at least two melting peaks including (i) a lowest temperature melting peak of not lower than 100° C. and not higher than 130° C. and (ii) a highest temperature melting peak of not lower than 140° C. and not higher than 160° C., the propylene resin having a resin DSC ratio change rate of 0.5%/° C. to 3.0%/° C., the expanded particles having two melting peaks in a DSC measurement made at a first temperature rise at the heating rate of 10 g/min, the two melting peaks including, (i) on a lower temperature side, a melting peak temperature of not lower than 100° C. and not higher than 130° C. and, (ii) on a higher temperature side, a melting peak temperature of not lower than 140° C. and not higher than 160° C. allow an in-mold foaming molded product to be produced of expanded particles that (i) have only a small change in expanded particle DSC ratio, the change corresponding to a change in foaming temperature, (ii) allow production of an in-mold foaming molded product at a very low mold heating steam pressure, (iii) exhibit low distortion, low shrinkage, and a wide range of heating conditions for molding, even if the mold heating steam pressure is increased, (iv) indicate a satisfactory moldability even in a case where the expanded particles are molded with use of, for example, a mold having a complicated shape, a large mold, and (v) keep its properties such as compressive strength, without being impaired largely, in a case where the polypropylene resin expanded particles are used to prepare an in-mold foaming molded product.

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05-12-2013 дата публикации

Antibodies that bind the glutamate ligand binding region of notch3

Номер: US20130323257A1
Принадлежит: OncoMed Pharmaceuticals Inc

Isolated antibodies that specifically binds to an extracellular conserved ligand binding region of a human Notch receptor and inhibits growth of a tumor are described. Also described are methods of treating cancer, the method comprising administering an anti-Notch antibody in an amount effective to inhibit tumor growth.

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12-12-2013 дата публикации

Encasement for preventing bed bug escapement via a zipper opening

Номер: US20130326820A1
Принадлежит: JAB Distributors Inc

The present technology provides an encasement comprising a fabric cover formed of bed bug impervious fabric. The encasement comprises an opening with a zipper mechanism disposed therein and operable to close the opening. The encasement also comprises a barrier attached to the fabric cover, extending along and opposite the zipper tracks. The encasement also comprises a channel between the barrier and said zipper tracks that receives a portion of the zipper head and becomes an enclosed channel when said zipper tracks are mated together. The channel has a confined space of a size to thwart bug movement along the channel.

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12-12-2013 дата публикации

Chemokine receptor binding polypeptides

Номер: US20130330346A1
Принадлежит: Individual

The present invention relates to polypeptides directed against or specifically binding to chemokine receptor CXCR2 and in particular to polypeptides capable of modulating signal transduction from CXCR2. The invention also relates to nucleic acids, vectors and host cells capable of expressing the polypeptides of the invention, pharmaceutical compositions comprising the polypeptides and uses of said polypeptides and compositions for treatment of diseases involving aberrant functioning of CXCR2.

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19-12-2013 дата публикации

Surfactant Composition and Method for Decontamination

Номер: US20130338420A1
Принадлежит: Procter and Gamble Co

Cleaning compositions, methods for cleaning exterior surfaces of a vehicle, and cleaning compositions for cleaning exterior surfaces of a vehicle are disclosed. The cleaning compositions include a C 8-22 alkyl dimethylamine oxide surfactant, a C 6-12 alkyl dimethylamine oxide surfactant, a C 8-18 alkyl polyethylene glycol sorbitan fatty ester surfactant, and a C 12-14 secondary alcohol ethoxylate surfactant are disclosed. The methods include providing a cleaning composition, applying the cleaning composition to exterior surfaces of a vehicle, and rinsing the exterior surfaces of the vehicle.

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02-01-2014 дата публикации

Method and Apparatus for Monitoring A Refrigeration-Cycle System

Номер: US20140000291A1
Автор: Lawrence Kates
Принадлежит: Emerson Climate Technologies Inc

A monitoring system for monitoring operation of a refrigerant-cycle system is disclosed. A condenser unit sensor measures an operating characteristic of a condenser unit, the condenser unit including a condenser and a compressor. An evaporator unit sensor measures an operating characteristic of an evaporator unit, the evaporator unit including an evaporator and a fan. An electrical sensor measures an electrical quantity indicative of power consumption of the refrigerant-cycle system. A processing system calculates an efficiency of the refrigerant-cycle system based on the power consumption of the refrigerant-cycle system, the operating characteristic of the condenser unit, and the operating characteristic of the evaporator unit.

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06-03-2014 дата публикации

Polymer-modified asphalt compositions

Номер: US20140066549A1

A modified-asphalt composition prepared by introducing a diene end-capped block copolymer with a molten asphalt composition, where the block copolymer is defined by the formula α-(D-V-d) x where each D is independently a polydiene block, each V is independently a vinyl aromatic block, each d is a polydiene end cap, α is a coupling moiety, and x is an integer from 2 to 10.

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27-03-2014 дата публикации

Vacuum cleaner

Номер: US20140082883A1
Автор: Phong Hoang Tran
Принадлежит: Bissell Homecare Inc

A vacuum cleaner has a cyclone separator for separating dirt and other contaminants from a dirt-containing working airstream and a collection chamber collecting the separated dirt. The vacuum cleaner can further include handle defining a fines catcher downstream of the cyclonic separation stage for collecting fine dirt, where the handle can be used to remove the fines catcher and/or an exhaust grill from the cyclone separator.

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02-01-2020 дата публикации

ADMINISTRATION OF A THIOL-BASED CHEMOPROTECTANT COMPOUND

Номер: US20200000844A1
Принадлежит:

A method of administration of a thiol-based chemoprotectant agent including NAC (N-acetylcysteine) and STS (sodium thiosulfate) that markedly affects biodistribution and protects against injury from diagnostic or therapeutic intra-arterial procedures. A method for treating or mitigating the side effects of cytotoxic cancer therapy for tumors located in the head or neck and brain tumors. The thiol-based chemoprotectant agent is administered intra-arterially with rapid and first pass uptake in organs and tissues other than the liver. 1. A method for treating or mitigating the side effects of cytotoxic cancer therapy comprising administering sodium thiosulfate (STS) in conjunction with a cis-platinum compound , wherein the STS is administered about 4 hours after administration of the cis-platinum compound , and wherein the STS is at a dose from 5 g/mto 40 g/m.2. The method for treating or mitigating the side effects of cytotoxic cancer therapy of wherein the STS is administered intravenously.3. The method for treating or mitigating the side effects of cytotoxic cancer therapy of wherein the STS is administered intra-arterially.4. The method for treating or mitigating the side effects of cytotoxic cancer therapy of wherein the cancer is a cancer located in the brain claim 3 , head or neck.5. A method for treating or mitigating the side effects of cytotoxic cancer therapy comprising administering sodium thiosulfate (STS) in conjunction with a cis-platinum compound claim 3 , wherein the STS is administered from about 4 hours to 8 hours after administration of the cis-platinum compound claim 3 , and wherein the STS is at a dose from 5 g/mto 40 g/m.6. A method for treating or mitigating the side effects of cytotoxic cancer therapy comprising administering sodium thiosulfate (STS) in conjunction with a cis-platinum compound claim 3 , wherein the STS is administered about 4 hours after administration of the cis-platinum compound claim 3 , and wherein the STS is administered ...

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05-01-2017 дата публикации

PROCESS FOR THE NANOSTRUCTURING OF A BLOCK COPOLYMER FILM USING A NONSTRUCTURED BLOCK COPOLYMER BASED ON STYRENE AND ON METHYL METHACRYLATE, AND NANOSTRUCTURED BLOCK COPOLYMER FILM

Номер: US20170002127A1
Принадлежит: Arkema France

The invention relates to a block copolymer film nanostructured in nanodomains at a predetermined temperature, obtained from a basic block copolymer which is nonstructured at said predetermined temperature, and at least one block of which comprises styrene and at least another block of which comprises methyl methacrylate. The block copolymer film is useful for forming nano-lithography masks. 1. A block copolymer film nano-structured into nano-domains at a determined temperature , obtained from a basic block copolymer non-structured at said determined temperature and having at least one block comprising styrene and at least one other block comprising methyl methacrylate , wherein the block copolymer film has the following modified chemical formula:{'br': None, 'sub': α(i)', 'γ', 'n', 'β(k)', 'δ', 'n-1', 'α(i+1)', 'ε', 'n-2', 'β(k+1)', 'ζ', 'n-3', 'β(k+x)', 'ω', 'n-p, '(A-co-C)-b-(B-co-D)-b-(A-co-E)-b-(B-co-F)-b- . . . -b-(B-co-W)\u2003\u2003(I)'}where:“n” represents the number of blocks of the block copolymer;“A” represents styrene and “B” represents methyl methacrylate, or conversely;“C”, “D”, “E”, “F”, . . . , “W” respectively represent a co-monomer or mixture of co-monomers incorporated in each of the blocks of the block copolymer, the co-monomer or mixture of co-monomers incorporated in a styrene block differing from the co-monomer or mixture of co-monomers incorporated in a methyl methacrylate block;the subscripts αi and βk represent the number of units of styrene or methyl methacrylate monomers contained in each block of the block copolymer, and are all independent of one another;the subscripts γ, δ, ε, ζ . . . , and ω represent the number of co-monomer units in a given block, and are all independent of one another;the subscripts αi, βk, γ, δ, ε, ζ . . . , and ω are all greater than or equal to 1.2. The block copolymer film according to claim 1 , wherein said co-monomers or mixtures of co-monomers incorporated in each of the blocks are all chemically and/or ...

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04-01-2018 дата публикации

HF COIL ASSEMBLY

Номер: US20180003782A1
Принадлежит:

An HF coil assembly for generating independent alternating magnetic fields in an examination volume of a magnetic resonance apparatus is presented, the HF coil assembly comprising a first coil pair of saddle coils and a second coil pair of saddle coils, each saddle coil having longitudinal conductor elements and curved conductor elements arranged along a common lateral surface of a circular cylinder having a cylinder axis. Each coil pair comprises curved conductor elements and longitudinal conductor elements which are interconnected at a high frequency. The saddle coils also have diagonal conductor elements and/or bridge elements that connect the longitudinal and curved conductor elements. The coil pairs are opposite to each other relative to the cylinder axis. 2. The HF coil assembly according to claim 1 , wherein at least one of the bridge elements is an electrically conductive element.3. The HF coil assembly according to claim 1 , wherein at least one of the bridge elements is a capacitor.4. The HF coil assembly according to claim 1 , wherein at least the first coil pair or the second coil pair comprises diagonal conductor elements claim 1 , which extend along a helical line on the lateral surface.5. The HF coil assembly according to claim 4 , wherein the bridge elements of the first coil pair claim 4 , which are arranged diagonally claim 4 , cross over the diagonal conductor elements of the second coil pair claim 4 , and/or wherein the bridge elements of the second coil pair claim 4 , which are arranged diagonally claim 4 , cross over the diagonal conductor elements of the first coil pair.6. The HF coil assembly according to claim 1 , wherein the curved conductor elements of the first coil pair and the curved conductor elements of the second coil pair are oriented axially toward each other.7. The HF coil assembly according to claim 1 , wherein the azimuthal opening angle of the saddle coils of at least the first coil pair or the second coil pair is between 100° ...

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14-01-2016 дата публикации

Compositions produced using enteric pathogens and methods of use

Номер: US20160008450A1
Принадлежит: Epitopix LLC

The present invention provides compositions including polypeptides having the characteristics of polypeptides expressed by a reference microbe such E. coli or Salmonella . Examples of Salmonella strains that can be used include, for instance, S. enterica serovar Newport, S. enterica serovar Enteritidis, S. enterica serovar Typhimurium , and S. enterica serovar Dublin. Also provided are compositions including polypeptides having a particular molecular weight and a mass fingerprint that includes polypeptide fragments having a particular set of masses, or polypeptides having an amino acid sequence with at least about 95% identity with an amino acid sequence, wherein the polypeptide has seroreactive activity. The present invention also provides methods of making and methods of using such compositions.

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11-01-2018 дата публикации

RETINOID REPLACEMENTS AND OPSIN AGONISTS AND METHODS FOR THE USE THEREOF

Номер: US20180008556A9
Принадлежит: UNIVERSITY OF WASHINGTON

Compositions of and methods for using synthetic retinoids as retinoid replacements and opsin agonists are provided. 158-. (canceled)59. A method of treating a visual disorder in an aging subject due to a deficiency of 11-cis retinal in an eye of the aging human subject , comprising:administering a therapeutically effective amount of a synthetic retinoid to an eye of the aging human subject in need of such, wherein the human subject has a deficiency of endogenous 11-cis-retinal in the eye and the synthetic retinoid is a cis-retinoid that forms a functional opsin/chromophore complex in the eye.60. The method of claim 59 , wherein the visual disorder associated with a deficiency of endogenous 11-cis-retinal in the eye is selected from decrease of night vision claim 59 , decrease of contrast sensitivity claim 59 , and age-related macular degeneration.61. The method of claim 60 , wherein the age-related macular degeneration (AMD) comprises dry AMD.62. The method of claim 59 , wherein the aging subject is at least 45 years old.63. The method of claim 59 , wherein administering the synthetic retinoid comprises locally administering to the eye of the human subject.64. The method of claim 63 , wherein the locally administering is by eye drops claim 63 , intraocular injection or periocular injection.65. The method of claim 63 , wherein administering the synthetic retinoid comprises systemically administering by an oral dosage form or an injection.67. The method of claim 59 , wherein the synthetic retinoid is 9-cis-retinal.68. A method of treating age-related macular degeneration (AMD) claim 59 , a decrease of night vision claim 59 , or a decrease of contrast sensitivity in an aging human subject claim 59 , comprising:administering a synthetic retinoid to an eye of the aging human subject, wherein the human subject has a deficiency of endogenous 11-cis-retinal in the eye and the synthetic retinoid is a cis-retinoid that forms a functional opsin/chromophore complex in the eye. ...

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14-01-2021 дата публикации

METHODS OF USING DIAMINOPYRIMIDINE P2X3 AND P2X2/3 RECEPTOR MODULATORS FOR TREATMENT OF RESPIRATORY AND GASTROINTESTINAL DISEASES

Номер: US20210008071A1
Принадлежит: Roche Palo Alto LLC

Methods for treating respiratory and gastrointestinal diseases mediated by a P2Xand/or a P2Xreceptor antagonist, the methods comprising administering to a subject in need thereof an effective amount of a compound of formula (I): 2. The method of claim 1 , wherein X is: —CH— or —O—.3. The method of claim 2 , wherein Y is —NRR.4. The method of claim 3 , wherein Ris alkyl claim 3 , alkenyl or cycloalkyl.5. The method of claim 4 , wherein Rand Rare hydrogen.6. The method of claim 5 , wherein Ris hydrogen.7. The method of claim 6 , wherein one of Rand Ris hydrogen and the other is hydrogen claim 6 , alkyl claim 6 , hydroxyalkyl or haloalkyl.8. The method of claim 6 , wherein one of Rand Ris hydrogen and the other is hydrogen claim 6 , alkyl claim 6 , hydroxyalkyl or haloalkyl.9. The method of claim 6 , wherein Rand Reach independently is halo claim 6 , alkoxy claim 6 , hydroxy claim 6 , haloalkoxy; aminosulfonyl; or alkylsulfonyl.10. The method of claim 6 , wherein R claim 6 , R claim 6 , Rand Rare hydrogen.11. The method of claim 9 , wherein Ris isopropyl.12. The method of claim 1 , wherein Ris heteroaryl.13. The method of claim 1 , wherein Rand Rtogether with the atoms to which they are attached form a five or six membered ring that includes one or two heteroatoms selected from O claim 1 , N and S.14. The method of claim 1 , wherein Rand Rtogether with the atoms to which they are attached form a five or six membered ring that includes one or two heteroatoms selected from O claim 1 , N and S.16. The method of claim 15 , wherein Ris isopropyl.17. The method of claim 16 , wherein Ris halo claim 16 , alkoxy claim 16 , haloalkoxy or hydroxy.18. The method of claim 17 , wherein Ris halo claim 17 , alkoxy claim 17 , alkylsulfonyl claim 17 , aminosulfonyl or heteroaryl.23. The method of claim 22 , wherein Ris halo claim 22 , alkoxy claim 22 , haloalkoxy or hydroxy.24. The method of claim 23 , wherein Ris halo claim 23 , alkoxy claim 23 , alkylsulfonyl or aminosulfonyl.27. The ...

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11-01-2018 дата публикации

KITS AND METHODS FOR NUTRITION SUPPLEMENTATION

Номер: US20180008634A1
Принадлежит: Exeltis USA, Inc.

The present invention relates to methods of co-administration of various vitamins and mineral compositions, and in a specific embodiment, said methods comprise co-administering one composition comprising vitamin A, beta carotene, B-complex vitamins, vitamin C, vitamin D, vitamin E, iron, magnesium and zinc, and a second composition comprising omega-3 fatty acids such as DHA, to supplement the nutritional needs of individuals within physiologically stressful states; and kits provided for co-administration of various vitamin and mineral compositions, and in a specific embodiment, said kits comprise one composition comprising vitamin A, beta carotene, B-complex vitamins, vitamin C, vitamin D, vitamin E, iron, magnesium and zinc, and a second composition comprising omega-3 fatty acids, such as DHA, to supplement the nutritional needs of individuals within physiologically stressful states. 1. A kit comprising:{'sub': 1', '2', '3', '6', '9', '12', '3, 'a first flavored and chewable composition comprising vitamins and minerals and one or more pharmaceutically-acceptable carriers, wherein the vitamins and minerals being one or more selected from the group consisting of: vitamin A, beta carotene, vitamin B, vitamin B, vitamin B, vitamin B, vitamin B, vitamin B, vitamin C, vitamin D, vitamin E, iron, magnesium and zinc, and wherein the one or more pharmaceutically-acceptable carriers; and'}a second flavored soft gel composition comprising omega-3 fatty acids and one or more pharmaceutically-acceptable carriers.2. The kit of claim 1 , wherein the one or more pharmaceutically-acceptable carriers for the first composition comprises one or both of a flavorant and a sweetener.3. The kit of claim 2 , wherein the flavorant is one or more selected from the group consisting of: natural flavor oils claim 2 , synthetic flavor oils claim 2 , flavoring aromatics claim 2 , extracts from plants claim 2 , extracts from leaves claim 2 , extracts from flowers claim 2 , extracts from fruits ...

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14-01-2021 дата публикации

Treatment and Prophylaxis of Amyloidosis

Номер: US20210008185A1

Methods useful for effecting prophylaxis or treatment of amyloidosis, including AA Amyloidosis and AL amyloidosis, by administering peptides comprising neoepitopes, such as AA fragments from a C-terminal region of AA, and antibodies specific for neoepitopes of aggregated amyloid proteins, for example, antibodies specific for the C-terminal region of AA fibrils. Antibodies for inhibition of formation and/or increasing clearance of amyloid deposits in a patient thus effecting prophylaxis or treating amyloid disease.

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10-01-2019 дата публикации

COMPOSITION FOR ADMINISTERING AN NMDA RECEPTOR ANTAGONIST TO A SUBJECT

Номер: US20190008799A1
Принадлежит:

The invention provides extended release amantadine compositions for once daily administration of amantadine to a subject. 1. A pharmaceutical composition in a unit dosage form comprising memantine or a pharmaceutically acceptable salt thereof , wherein the pharmaceutical composition is in a sustained release form , and wherein the pharmaceutical composition comprises coated cores having about 8% to 16.5% (by weight) of a sustained release coating comprising:(i) ethyl cellulose; and(ii) hydroxypropylmethyl cellulose (HPMC);wherein the ethyl cellulose to HPMC ratio is about 8:2 to 9:1.2. The pharmaceutical composition of claim 1 , wherein the sustained release coating is substantially resistant to gastric conditions.3. The pharmaceutical composition of claim 1 , wherein the sustained release coating is erodible under conditions prevailing in the gastrointestinal tract.4. The pharmaceutical composition of claim 1 , comprising 12.5 mg to 40 mg memantine or a pharmaceutically acceptable salt thereof.5. The pharmaceutical composition of claim 1 , comprising 20 mg to 40 mg memantine or a pharmaceutically acceptable salt thereof.6. The pharmaceutical composition of claim 1 , comprising 22.5 mg to 40 mg memantine or a pharmaceutically acceptable salt thereof.7. The pharmaceutical composition of claim 1 , having a memantine in vitro dissolution profile of between 0.1% to 20% in one hour claim 1 , 5% to 30% in two hours claim 1 , 40% to 80% in six hours claim 1 , and 50% to 90% in 10 hours claim 1 , wherein the in vitro dissolution profile is determined using a USP type 2 (paddle) dissolution system at 50 rpm claim 1 , at a temperature of 37±0.5° C. claim 1 , in 500 ml water.8. The pharmaceutical composition of claim 1 , wherein the sustained release coating comprises about 11.2% to 16.5% (by weight) of the pharmaceutical composition.9. A pharmaceutical composition in a unit dosage form comprising memantine or a pharmaceutically acceptable salt thereof claim 1 , wherein the ...

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14-01-2021 дата публикации

CATALYZED SCR FILTER AND EMISSION TREATMENT SYSTEM

Номер: US20210008531A1
Принадлежит:

Provided is a catalyst article for simultaneously remediating the nitrogen oxides (NOx), particulate matter, and gaseous hydrocarbons present in diesel engine exhaust streams. The catalyst article has a soot filter coated with a material effective in the Selective Catalytic Reduction (SCR) of NOx by a reductant, e.g., ammonia. 1. A catalyst article consisting essentially of a wall flow monolith and a catalytic material , wherein the wall flow monolith has a plurality of longitudinally extending passages fatined by longitudinally extending walls bounding and defining said passages , wherein the passages comprise inlet passages having an open inlet end and a closed outlet end , and outlet passages having a closed inlet end and an open outlet end , the wall flow monolith has a porosity of from 50% to 60% and an average pore size of from 10 to 25 microns , and the wall flow monolith contains the catalytic material;{'sup': '3', 'wherein the catalytic material comprises an SCR catalyst composition including a slurry-loaded washcoat of a zeolite and base metal selected from one or more of a copper and iron component, the washcoat permeating the walls at a loading up to 2.4 g/in, the wall flow monolith having integrated, NOx and particulate removal efficiency in which presence of the catalytic material in the wall flow monolith catalyzes the oxidation of soot.'}2. The catalyst article of claim 1 , wherein the SCR catalyst composition permeates the walls of the monolith at a concentration of at least 1.3 g/in.3. The catalyst article of claim 2 , wherein there is from 1.6 to 2.4 g/inof SCR catalyst composition disposed on the wall flow monolith.4. The catalyst article of claim 1 , wherein the SCR catalyst composition is effective to catalyze the reduction of NOx at a temperature below about 600° C. and is able to aid in regeneration of the wall flow monolith by lowering the temperature at which soot captured by the wall flow monolith is combusted.5. The catalyst article of ...

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