21-03-2013 дата публикации
Номер: US20130072543A1
The invention relates to compositions containing compounds of formula I: 2. A lipid nanoparticle composition of comprising a compound of formula I claim 1 , wherein R is linoleyl claim 1 , Ris chloromethyl; Rand Rare methyl; and n is 2.3. A lipid nanoparticle composition of comprising:{'claim-ref': {'@idref': 'CLM-00001', 'claim 1'}, 'a) a compound of formula I in ;'} 1,2-dipalmitoyl-sn-glycero-3-phosphocholine,', '1,2-distearoyl-sn-glycero-3-phosphocholine, and', '1,2-dioleoyl-sn-glycero-3-phosphocholine;, 'b) a phospholipid selected from the group consisting ofc) cholesterol; [{'sub': '2000', 'R-3-[(ω-methoxy-poly(ethyleneglycol))carbamoyl]-1,2-dimyristyloxy-propyl-3-amine; and'}, '1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000]; and, 'd) a pegylated lipid compound selected from the group consisting ofe) a polynucleotide.4. A lipid nanoparticle composition of comprising:{'claim-ref': {'@idref': 'CLM-00001', 'claim 1'}, 'claim-text': N-(chloromethyl)-2-(2,2-di((9Z,12Z)-octadeca-9,12-dienyl)-1,3-dioxolan-4-yl)-N,N-dimethylethanamonium chloride;', '2-(2,2-di((9Z,12Z)-octadeca-9,12-dienyl)-1,3-dioxolan-4-yl)-N,N,N-trimethyl-ethanamonium iodide; and', '2-(2,2-di((9Z,12Z)-octadeca-9,12-dienyl)-1,3-dioxolan-4-yl)-N-ethyl-N,N-dimethyl-ethanamonium iodide;, 'a) a compound of formula I in selected from the group consisting of'} 1,2-dipalmitoyl-sn-glycero-3-phosphocholine,', '1,2-distearoyl-sn-glycero-3-phosphocholine, and', '1,2-dioleoyl-sn-glycero-3-phosphocholine;, 'b) a phospholipid selected from the group consisting ofc) cholesterol; [{'sub': '2000', 'R-3-[(ω-methoxy-poly(ethyleneglycol))carbamoyl]-1,2-dimyristyloxy-propyl-3-amine; and'}, '1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N4methoxy(polyethylene glycol)-2000]; and, 'd) a pegylated lipid compound selected from the group consisting ofe) a polynucleotide.5. A lipid nanoparticle composition of further comprising claim 4 ,2-(2,2-di((9Z,12Z)-octadeca-9,12-dienyl)-1,3- ...
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