Holographic Sensor

A sensor for the detection of an analyte comprising a cis-diol moiety, which comprises a holographic element comprising a medium and a hologram disposed throughout the volume of the medium, wherein an optical characteristic of the element changes as a result of a variation of a physical property occurring throughout the volume of the medium, and wherein the medium is a polymer comprising a group of formula (i) wherein n is 0, 1, 2, 3 or 4; each X (if present) is independently is an atom or group which, via an electronic effect, promotes formation of a tetrahedral geometry about the boron atom; and Y is a spacer which, when n is 0 or otherwise optionally, is an atom or group which, via an electronic effect, promotes formation of a tetrahedral geometry about the boron atom. Such a sensor may be used for the detection of glucose.

Guided structured testing kit

A guided structured testing kit comprising a test strip container, a test strip meter, a testing protocol advisor, and at least one of diagnostic test strip is presented. The diagnostic test strip comprising a support element, a glucose reagent provided on the support element, and a glycemic context code provided on the support element. The glycemic context code can be machine-readable. The glycemic context code signals a glycemic context to a test strip meter, either upon insertion of the diagnostic test strip or by a user manually inputting the glycemic context into the test strip meter. A method for performing a guided structured test is also provided.

Integrated chemical sensor

A integrated circuit die includes a chemical sensor, a thermal sensor, and a humidity sensor formed therein. The chemical sensor, thermal sensor, and humidity sensor include electrodes formed in a passivation layer of the integrated circuit die. The integrated circuit die further includes transistors formed in a monocrystalline semiconductor layer.

Single chip having the chemical sensor and electronics on the same die

A semiconductor die includes a chemical sensor, a digital to analog converter, and microcontroller formed therein. The chemical sensor detects the presence of a chemical and outputs an analog signal to the digital to analog converter. The analog to digital converter converts the analog signal to a digital signal. The analog to digital converter outputs the digital signal to the microcontroller. Microcontroller calculates a value of the concentration of the selected chemical.

Calibration system for use with lateral flow assay test strips

A method of adjusting a final signal value measured on a lateral flow assay test strip, by: identifying a pre-determined calibration method for the test strip, wherein the pre-determined calibration method corresponds to the manufacturing lot from which the test strip has been made; measuring signal values while performing a lateral flow assay reaction on a test strip; determining a final signal value; and adjusting the final signal value based upon the identified pre-selected calibration method for the test strip.

Analyzing method and system for test strips

An exemplary test strip reading and analyzing system includes a test strip unit, a mobile device and a remote computing apparatus. The test strip unit includes at least one tested-object reacting region. The mobile device includes an image capture module for capturing a test-strip image of the test strip unit and a transmission module electrically coupled to the image capture module. The remote computing apparatus, installed with a test strip analyzing system, is for analyzing the test-strip image and accordingly generating an test report. The test-strip image captured by the image capture module is transmitted to the remote computing apparatus through the transmission module; and the test report generated by the remote computing apparatus is consequently transmitted to the mobile device.

Embossed Cell Analyte Sensor and Methods of Manufacture

An analyte measurement system is provided having sensors with embossed test chamber channels. In one embodiment, the sensors are elongate test strips for in vitro testing, each test strip having a substrate, at least one electrode, an embossed channel in the electrode, and lidding tape covering at least a portion of the embossed channel. Methods of manufacture are also disclosed for filling the sensor channels with reagent, and for trimming the ends of the sensors to eliminate the need for a calibration code during use of the sensors with a meter.

Control Solution For Use In An Electrochemical System

A method of distinguishing a control solution from a sample in an electrochemical test sensor is performed. The method includes adding a control marker to the control solution. The control solution includes the control marker and analyte. The test sensor includes working and counter electrodes, and a reagent. A potential is applied to the test sensor to oxidize the control marker and the analyte. The resulting electrical current is measured. A potential is applied to the test sensor lower than the other potential in which the potential is sufficient to oxidize the analyte and not the control marker. The resulting electrical current is measured. Determining whether a control solution or a sample is present based on the measured electrical currents. To increase the measured current, a salt may be added to the control solution in an amount sufficient to increase the electrical current by at least 5% as compared to a control solution in the absence of a salt.

Aqueous radiation protecting formulations and methods for making and using them

Medical devices are typically sterilized in processes used to manufacture such products and their sterilization by exposure to radiation is a common practice. Radiation has a number of advantages over other sterilization processes including a high penetrating ability, relatively low chemical reactivity, and instantaneous effects without the need to control temperature, pressure, vacuum, or humidity. Unfortunately, radiation sterilization can compromise the function of certain components of medical devices. For example, radiation sterilization can lead to loss of protein activity and/or lead to bleaching of various dye compounds. Embodiments of the invention provide methods and materials that can be used to protect medical devices from unwanted effects of radiation sterilization.

Fluid injection and safety system

Various medical systems and methods are described, including a medical monitoring system. The medical monitoring system can have a fluid system configured to receive bodily fluid and optically analyze said fluid to determine analyte concentration. The fluid system can have a removable portion. The removable portion can have an opening with a port. The system can also have a container configured to contain anticoagulant. The container can have a portion configured to mate with the port of the removable portion. The container can be further configured to not fit into a conventional luer fitting. An anti-coagulant insertion apparatus is also described. The apparatus can have a syringe, a dock with a port, and an adapter configured to connect the syringe to the port. The dock can also have a tab configured to move with the port.

Method and apparatus for lighted test strip

A test strip with a sample chamber is secured to a meter. The sample chamber in the portion of the test strip that extends out of the meter is illuminated by transmitting light from a light source inside the meter internally through the test strip towards the sample chamber. By way of analogy, the test strip acts in a fashion similar to a fiber optic cable or optical wave guide by transmitting the light from the meter to the remotely located sample chamber that extends outside the meter. The user is then able to easily see the sample chamber of the test strip in dark conditions so that the user is able to readily align the sample chamber with the drop of fluid on the skin as well as view the sample chamber in order to ensure proper filling. The light also illuminates a test strip slot into which the test strip is inserted.

Method and Device for Providing Offset Model Based Calibration for Analyte Sensor

Methods and devices to detect analyte in body fluid are provided. Embodiments include processing sampled data from analyte sensor, determining a single, fixed, normal sensitivity value associated with the analyte sensor, estimating a windowed offset value associated with the analyte sensor for each available sampled data cluster, computing a time varying offset based on the estimated windowed offset value, and applying the time varying offset and the determined normal sensitivity value to the processed sampled data to estimate an analyte level for the sensor.

Glucose Measuring Device for Use in Personal Area Network

A glucose measuring system includes a glucose meter that incorporates wireless communication capabilities. The meter can advantageously be a low cost meter by eliminating expensive components, such as the display. The user nevertheless is able to retrieve and view his or her glucose values by referring to displays within the glucose measuring local area network. Feedback via these displays can advantageously be used by the diabetic to create a higher level of confidence and safety. 1a client unit including a client wireless communication module and a glucose sensor in contact with a bodily fluid to determine a glucose level in the bodily fluid and generate corresponding glucose data, the bodily fluid comprising one of blood or interstitial fluid; and 'wherein the automobile comprises programming that includes one or more acceptable glucose level ranges, and wherein one or more functions of the automobile is configured to be disabled until the received glucose data is within the one or more acceptable glucose level ranges.', 'an automobile including an automobile communication module configured to communicate with the client unit to receive the glucose data from the client unit;'}. A data communication system, comprising: This application is a continuation of Ser. No. 14/176,822 filed on Feb. 10, 2014, now U.S. Pat. No. 9,730,584, which is a continuation of U.S. patent application Ser. No. 12/426,887 filed on Apr. 20, 2009, now U.S. Pat. No. 8,647,269, which is a continuation of U.S. patent application Ser. No. 10/861,625 filed on Jun. 4, 2004, now U.S. Pat. No. 8,066,639, entitled “Glucose Measuring Device For Use In Personal Area Network”, which claims priority to U.S. Provisional Patent Application No. 60/477,730 filed on Jun. 10, 2003, entitled “Glucose Measuring Device For Use In Personal Area Network”, the disclosures of each of which are incorporated herein by reference for all purposes.This invention relates to a device and method for determining and ...

Method of using a control solution and preparing for testing using the same

A method of distinguishing a control solution from a sample in an electrochemical test sensor is performed. The method includes adding a control marker to the control solution. The control solution includes the control marker and analyte. The test sensor includes working and counter electrodes, and a reagent. A potential is applied to the test sensor to oxidize the control marker and the analyte. The resulting electrical current is measured. A potential is applied to the test sensor lower than the other potential in which the potential is sufficient to oxidize the analyte and not the control marker. The resulting electrical current is measured. Determining whether a control solution or a sample is present based on the measured electrical currents. To increase the measured current, a salt may be added to the control solution in an amount sufficient to increase the electrical current by at least 5% as compared to a control solution in the absence of a salt.

SYSTEMS AND METHODS FOR MONITORING OF FRACTIONAL GLUCONEOGENESIS AND TARGETING OF FRACTIONAL GLUCONEOGENESIS VIA NUTRITIONAL SUPPORT

Systems, techniques and methods for estimating the metabolic state or flux, e.g., the body energy state (“BES”) of a patient, are disclosed. The BES provides a deep insight into the nutritional needs of the patient, thus allowing for a sort of exquisite glycemic control with regard to the patient. The invention discloses systems and methods for estimating fractional gluconeogenesis. The invention also discloses systems and methods for estimating and targeting patient blood lactate concentration, both as a target itself and as an intermediate step to estimating and targeting patient fractional gluconeogenesis glucose production. Nutritional support methods and formulations are also disclosed. The invention is suitable for any sort of patient, including those who are injured, such as with traumatic brain injury, ill, or have other conditions that stress the metabolic system. 1. A method of preventing or treating body wasting in a patient with traumatic brain injury , the method comprising:receiving a value or set of values for a fractional gluconeogenesis from one or more mass spectrometric readings from a blood sample from the patient, the value or set of values received directly, or indirectly over a network, from one or more mass spectrometric instruments; andadministering, based on the value or set of values, if the fractional gluconeogenesis is above about 15-30%, administering a nutritional support to the patient.2. The method of wherein the administering is further based on a fractional gluconeogenesis is above about 20-25%.3. The method of wherein the nutritional support comprises one or more salts.4. The method of wherein the nutritional support comprises lactate or pyruvate or both.5. The method of wherein the nutritional support has a milliosmolality of less than about 1000.6. The method of wherein the nutritional support comprises an amino acid.7. The method of wherein the nutritional support comprises one or more of the following: glycerol claim 1 , ...

Fluorophore and fluorescent sensor compound containing same

The invention provides fluorophores of formulae (I) and (II) and also fluorescent sensor compounds comprising fluorophore moieties based on such fluorophores in combination with a receptor moiety: There is further provided a method of sensing the presence of a target analyte using the fluorescent sensor compound, as well as the use of the fluorescent sensor compounds to sense a target analyte.

Method and Device for Providing Offset Model Based Calibration for Analyte Sensor

Methods and devices to detect analyte in body fluid are provided. Embodiments include processing sampled data from analyte sensor, determining a single, fixed, normal sensitivity value associated with the analyte sensor, estimating a windowed offset value associated with the analyte sensor for each available sampled data cluster, computing a time varying offset based on the estimated windowed offset value, and applying the time varying offset and the determined normal sensitivity value to the processed sampled data to estimate an analyte level for the sensor.

Systems and methods to estimate nutritional needs of human and other patients

Systems, techniques and methods for estimating the metabolic state or flux, e.g., the body energy state (“BES”) of a patient, are disclosed. The BES provides deep insight into the nutritional needs of the patient, thus allowing for a sort of exquisite glycemic control with regard to the patient. The invention discloses systems and methods for estimating fractional gluconeogenesis, which is the % of glucose production that comes from gluconeogenesis (“GNG”), as opposed to glycogenolysis (“GLY”), the other form of glucose production. Nutritional formulations, materials, cocktails and methods for feeding patients by parenteral and other means are disclosed. The amount, type and rate of such nutritional feeding are typically based upon the above estimating. The invention discloses formulations that contain labels, such as deuterium, for medical diagnostics, such as for estimating BES and fractional gluconeogenesis. The invention is suitable for any sort of patient, including those who are injured, such as with traumatic brain injury, ill, or have other conditions that stress the metabolic system.

FLUID INJECTION AND SAFETY SYSTEM

Various medical systems and methods are described, including a medical monitoring system. The medical monitoring system can have a fluid system configured to receive bodily fluid and optically analyze said fluid to determine analyte concentration. The fluid system can have a removable portion. The removable portion can have an opening with a port. The system can also have a container configured to contain anticoagulant. The container can have a portion configured to mate with the port of the removable portion. The container can be further configured to not fit into a conventional luer fitting. An anti-coagulant insertion apparatus is also described. The apparatus can have a syringe, a dock with a port, and an adapter configured to connect the syringe to the port. The dock can also have a tab configured to move with the port. 1. (canceled)2. A medical device and automated setup instruction system comprising: a non-disposable subsystem including at least one of a valve, a sensor or a pump; and', 'a removable cartridge configured to hold and prepare a sample of bodily fluid for analysis, the removable cartridge being comprising a safety port comprising an opening, the removable cartridge configured to be in fluid communication with a source of an anti-coagulant agent comprising an adapter that is configured to engage the safety port, and wherein the source of the anti-coagulant agent is not configured to engage conventional medical fittings;, 'a fluid system comprisinga display configured to be visible to a medical device user when the user is preparing the medical device for use in a medical setting;a computer memory configured to store setup information and protocols that are specific to the medical device; one or more sensors configured to detect configuration of components of the medical device and/or data regarding the environment in which the device is used;', 'one or more direct user input portions configured to accept input from the user relating to user- ...

Manufactured product with optically encoded particle tag and id method

The invention concerns an article of manufacture that is a manufactured product marked with a microparticle and a method of marking manufactured produces. The microparticle tag includes a predetermined code embedded in its physical structure by refractive index changes between different regions of the particle. The particle has a diameter of a few hundred microns or less and has a plurality of layers.

Analyte testing method and system

Various systems and methods of operating an analyte measurement device is provided. The device has a display, user interface, processor, memory and user interface buttons. In one example, one of the methods can be achieved by measuring an analyte with the analyte measurement device; displaying a value representative of the analyte; prompting a user to activate a test reminder; and activating the test reminder to remind a user to conduct a test measurement at a different time. Other methods and systems are also described and illustrated.

Glucose test strip authentication using ink

A method of authenticating includes providing a glucose test strip having a top surface with a reagent thereon that has a structure which chemically reacts with glucose and an anti-counterfeiting identification feature (identification feature) including at least one ink. The glucose test strip is inserted into a glucose meter. The glucose meter includes a light source positioned to shine light on the ink after the inserting, a photodetector positioned to detect a reflected or transmitted signal after interaction with the ink, and stored information that identifies the identification feature. A processor implementing an algorithm automatically analyzes the reflected or transmitted signal by reference to the stored information to determine whether the glucose test strip is authentic.

Methods and systems for analyzing a blood sample

A method of analyzing a blood sample is provided. The method comprises providing a glucometer configured to analyze a blood sample and a remote computing device separate from the glucometer, analyzing, by the glucometer, the blood sample, and presenting, by the glucometer, encoded results. The encoded results may be presented as a machine-readable visually-encoded representation of one or more results of the analysis, in which case the method further comprises imaging, by the remote computing device, the representation. The encoded results may be presented as a capacitive profile, in which case the method further comprises reading, by a capacitive sensing input mechanism of the remote computing device, the capacitive profile. According to either option, the method further comprises decoding, by the remote computing device, the representation, thereby retrieving at least one of the results.

Method for measuring carbohydrate metabolism ability, and composition for use in said method

This invention provides a method for measuring glucose metabolism ability of a subject and a composition that is suitably used in the method. The method for measuring glucose metabolism ability of the present invention is as follows: a method for measuring glucose metabolism ability of a subject, using a composition for measuring glucose metabolism ability, the composition comprising, as an active ingredient, glucose labeled with at least one isotope of C, wherein the glucose is converted in the body into labeled carbon dioxide that is excreted in expired air, the method comprising steps (a) and (b) below: (a) administering the composition to the subject and collecting expired air; and (b) determining the ratio of labeled CO 2 amount to unlabeled CO 2 amount or the ratio of labeled CO 2 amount to total CO 2 amount.

SYSTEMS AND METHODS FOR MONITORING OF FRACTIONAL GLUCONEOGENESIS AND TARGETING OF FRACTIONAL GLUCONEOGENESIS VIA NUTRITIONAL SUPPORT

Systems, techniques and methods for estimating the metabolic state or flux, e.g., the body energy state (“BES”) of a patient, are disclosed. The BES provides a deep insight into the nutritional needs of the patient, thus allowing for a sort of exquisite glycemic control with regard to the patient. The invention discloses systems and methods for estimating fractional gluconeogenesis. The invention also discloses systems and methods for estimating and targeting patient blood lactate concentration, both as a target itself and as an intermediate step to estimating and targeting patient fractional gluconeogenesis glucose production. Nutritional support methods and formulations are also disclosed. The invention is suitable for any sort of patient, including those who are injured, such as with traumatic brain injury, ill, or have other conditions that stress the metabolic system. 1. A method of preventing or treating body wasting in a human patient , the method comprising:receiving a value or set of values for a fractional gluconeogenesis from one or more mass spectrometric readings from a blood sample from the patient, the value or set of values received directly, or indirectly over a network, from one or more mass spectrometric instruments; andadministering, based on the value or set of values, if the fractional gluconeogenesis is above about 15-30%, a nutritional support to the patient, wherein the nutritional support comprises a label which is used to help determine the fractional gluconeogenesis.2. The method of wherein the administering is further based on a fractional gluconeogenesis is above about 20-25%.3. The method of wherein the nutritional support comprises one or more salts.4. The method of wherein the nutritional support comprises lactate or pyruvate or both.5. The method of wherein the nutritional support has a milliosmolality of less than about 1000.6. The method of wherein the nutritional support comprises an amino acid.7. The method of wherein the ...

SYSTEMS AND METHODS FOR MONITORING OF FRACTIONAL GLUCONEOGENESIS AND TARGETING OF FRACTIONAL GLUCONEOGENESIS VIA NUTRITIONAL SUPPORT

Systems, techniques and methods for estimating the metabolic state or flux, e.g., the body energy state (“BES”) of a patient, are disclosed. The BES provides a deep insight into the nutritional needs of the patient, thus allowing for a sort of exquisite glycemic control with regard to the patient. The invention discloses systems and methods for estimating fractional gluconeogenesis. The invention also discloses systems and methods for estimating and targeting patient blood lactate concentration, both as a target itself and as an intermediate step to estimating and targeting patient fractional gluconeogenesis glucose production. Nutritional support methods and formulations are also disclosed. The invention is suitable for any sort of patient, including those who are injured, such as with traumatic brain injury, ill, or have other conditions that stress the metabolic system. 179-. (canceled)80. A method of preventing or treating body wasting in a human patient , the method comprising:administering a molecular label;taking a blood sample;measuring incorporation of the molecular label into glucose in order to obtain a value or range of values for fractional gluconeogenesis; andadministering a formulation wherein the formulation is administered or increased if the fractional gluconeogenesis is above about 15-30%, wherein the nutritional support comprises at least some of the molecular label being administered.811. The method of claim wherein the administering is further based on a fractional gluconeogenesis is above about 20-25%.821. The method of claim wherein the nutritional support comprises one or more salts.831. The method of claim wherein the nutritional support comprises lactate or pyruvate or both.841. The method of claim wherein the nutritional support has a milliosmolality of less than about 1000.851. The method of claim wherein the nutritional support comprises an amino acid.861. The method of claim wherein the nutritional support comprises one or more of the ...

METHOD FOR MEASURING TEMPERATURE OF BIOLOGICAL SAMPLE, MEASURING DEVICE, AND BIOSENSOR SYSTEM

The concentration measurement method includes: introducing a predetermined amount of the biological sample into the capillary; measuring a temperature of the biological sample by applying a first voltage to the electrode unit when the temperature of the biological sample is measured, the first voltage allowing the temperature measurement to be less affected by increase and reduction in an amount of the analyte contained in the biological sample; measuring the concentration of the analyte contained in the biological sample by applying a second voltage to the electrode unit; measuring an environmental temperature in a surrounding of the biological sample; and correcting the concentration of the measured analyte based on the measured temperature of the biological sample and the measured environmental temperature. 15-. (canceled)6. A concentration measurement method of measuring a concentration of an analyte contained in a biological sample in a sensor chip including: an electrode unit including a working electrode and a counter electrode , the electrode unit including a reagent containing an electrolyte , and a capillary allowing the biological sample to be introduced therein , the concentration measurement method comprising:an introduction of introducing a predetermined amount of the biological sample into the capillary; performing a temperature measurement of measuring a temperature of the biological sample by applying a first voltage to the electrode unit when the temperature of the biological sample is measured, the first voltage allowing the temperature measurement to be less affected by increase and reduction in an amount of the analyte contained in the biological sample, and then a concentration measurement of measuring the concentration of the analyte contained in the biological sample by applying a second voltage to the electrode unit; or', 'performing the concentration measurement of measuring the concentration of the analyte, and then the temperature ...

Electrochemical Sensor System

An electrochemical sensor system comprises an electrochemical sensor and a hydrogel composition. The electrochemical sensor has at least a counter electrode and a working electrode. The hydrogel composition contacts the working electrode. The hydrogel composition comprises a first monomer, a second monomer, a cross-linking agent, and a solvent. The first monomer has hydrophilic characteristics. The second monomer has hydrophobic characteristics. The ratio of the first monomer to the second monomer is from about 0.1:99.9 to about 99.9:0.1. 171-. (canceled)73. The electrochemical sensor system of claim 72 , further including a mechanical support to assist in providing mechanical strength to the hydrogel composition.74. The electrochemical sensor system of claim 73 , wherein the mechanical support is polymeric mesh claim 73 , woven fabric claim 73 , non-woven fabric claim 73 , cellulose claim 73 , or combinations thereof.75. The electrochemical sensor system of claim 72 , wherein the hydrogel composition has a thickness of from about 0.1 mil to about 100 mils.76. The electrochemical sensor system of claim 75 , wherein the hydrogel composition has a thickness of from about 1 mil to about 30 mils.77. The electrochemical sensor system of claim 72 , wherein the ratio of the first monomer to the second monomer is from about 40:60 to about 60:40.78. The electrochemical sensor system of claim 72 , wherein the first monomer is N-vinyl pyrrolidone claim 72 , the second monomer being selected from Formula III with R5 being a (C-C)alkyl that is optionally substituted.79. The electrochemical sensor system of claim 72 , wherein the first monomer is N-vinyl caprolactam claim 72 , the second monomer being selected from Formula III with R5 being a (C-C)alkyl that is optionally substituted.82. The method of claim 81 , wherein the analyte is glucose.83. The method of claim 81 , wherein the sensor is an electrochemical sensor.84. The method of claim 81 , wherein the ratio of the first ...

Electrochemical Sensor System

An electrochemical sensor system comprises an electrochemical sensor and a hydrogel composition. The electrochemical sensor has at least a counter electrode and a working electrode. The hydrogel composition contacts the working electrode. The hydrogel composition comprises a first monomer, a second monomer, a cross-linking agent, and a solvent. The first monomer has hydrophilic characteristics. The second monomer has hydrophobic characteristics. The ratio of the first monomer to the second monomer is from about 0.1:99.9 to about 99.9:0.1. 171-. (canceled)73. The method of claim 72 , wherein the ratio of the first monomer to the second monomer is from about 40:60 to about 60:40.74. The method of claim 72 , wherein the analyte is glucose.75. The method of claim 72 , wherein the sensor is an electrochemical sensor.76. The method of claim 72 , wherein the first monomer is N-vinyl pyrrolidone.77. The method of claim 72 , wherein the first monomer is N-vinyl caprolactam.78. The method of claim 72 , wherein the first monomer is N-vinyl pyrrolidone claim 72 , the second monomer of Formula IV being a (C-C)cycloalkyl that is optionally substituted.79. The method of claim 72 , wherein the first monomer is N-vinyl caprolactam claim 72 , the second monomer of Formula IV being a (C-C)cycloalkyl that is optionally substituted.80. The method of claim 72 , wherein the hydrogel composition has a thickness of from about 0.1 mil to about 100 mils.81. The method of claim 72 , wherein the hydrogel composition has a thickness of from about 1 mil to about 30 mils.83. The electrochemical sensor system of claim 82 , wherein the ratio of the first monomer to the second monomer is from about 40:60 to about 60:40.84. The electrochemical sensor system of claim 82 , wherein the analyte is glucose.85. The electrochemical sensor system of claim 82 , wherein the first monomer is N-vinyl pyrrolidone.86. The electrochemical sensor system of claim 82 , wherein the first monomer is N-vinyl caprolactam. ...

System and Methods for Improved Diabetes Data Management and Use Employing Wireless Connectivity Between Patients and Healthcare Providers and Repository of Diabetes Management Information

Methods, devices and a system for disease management are provided that employ diagnostic testing devices (e.g., blood glucose meters) and medication delivery devices (e.g., insulin delivery devices) for providing data to a repository in real-time and automatically. Repository data can be analyzed to determine such information as actual test strip use, patient health parameters to outside prescribed ranges, testing and medication delivery compliance, patient profiles or stakeholders to receive promotional items or incentives, and so on. Connected meters and medication delivery devices and repository data analysis are also employed to associate a diagnostic test to a mealtime based on timing of a therapeutic intervention performed by an individual. 1. A disease management system comprising:a medication delivery syringe comprising a reservoir for medication, a needle, a plunger to control delivery of medication from the reservoir through the needle, and a radio frequency identification (RFid) tag comprising medication delivery information selected from the group consisting of a syringe identification number, medication type, and medication amount delivered; anda communication device comprising an RFid interface circuit configured to activate the RFid tag to transmit the medication delivery information from the syringe, and to receive and store the transmitted medication delivery information, and a communications interface circuit configured to wirelessly connect via at least one of a cellular network and a wireless internet network to a repository that stores disease management information, and to transmit the medication delivery information to the repository.2. The disease management system of claim 1 , wherein the communications interface circuit is configured to automatically claim 1 , without user involvement claim 1 , transmit the medication delivery information to the repository in response to detection of completion of delivery of the medication.3. The disease ...

Means and Methods for Diagnosing and Monitoring Heart Failure in a Subject

The present invention relates to the field of diagnostic methods. Specifically, the present invention contemplates a method for diagnosing heart failure in a subject and a method for monitoring progression or regression of heart failure in a subject. The invention also relates to tools for carrying out the aforementioned methods, such as diagnostic devices.

Method Of Using An Electrochemical Test Sensor

A method of distinguishing a control solution from a sample in an electrochemical test sensor is performed. The method includes adding a control marker to the control solution. The control solution includes the control marker and analyte. The test sensor includes working and counter electrodes, and a reagent. A potential is applied to the test sensor to oxidize the control marker and the analyte. The resulting electrical current is measured. A potential is applied to the test sensor lower than the other potential in which the potential is sufficient to oxidize the analyte and not the control marker. The resulting electrical current is measured. Determining whether a control solution or a sample is present based on the measured electrical currents. To increase the measured current, a salt may be added to the control solution in an amount sufficient to increase the electrical current by at least 5% as compared to a control solution in the absence of a salt. 138-. (canceled)39. A method of using an electrochemical test sensor , the method comprising the acts of:introducing a fluid sample to the electrochemical test sensor;applying a first voltage to the fluid sample;measuring a first current value of the fluid sample at the first voltage;applying a second voltage to the fluid sample;measuring a second current value of the fluid sample at the second voltage;comparing the first current value to a number so as to determine if the fluid sample is an analyte-fluid test sample; andif the comparison using the first current value does not result in determining whether the sample is an analyte-fluid test sample, then using at least the first current value at the first voltage and the second current value at the second voltage to determine whether a control solution or the analyte-fluid test sample is present,wherein the first voltage is higher than the second voltage.40. The method of claim 39 , wherein the comparing the first current value to a number so as to determine if the ...

DEVICE FOR DETECTING ANALYTE IN SAMPLE

A device for detecting an analyte in a sample is provided, which comprises: a collecting chamber containing an opening for collecting a liquid sample; a detecting element for detecting an analyte in the liquid sample; and a lid for covering the opening of the collecting chamber. The device further comprises an indicating device thereon to indicate whether or not the lid covers at an appointed position. The operation of the device is very simple. 1. A device for detecting an analyte in a sample , comprising:a) a collecting chamber having an opening for collecting a liquid sample;b) a detecting chamber having a detecting element for detecting the analyte in the liquid sample;c) a lid having a circumferential lid edge, the lid being configured to cover the opening; andd) an indicating device configured to indicate whether or not the lid covers the opening at an appointed position,wherein the indicating device generates a sound when the lid covers the opening at the appointed position resulting from elastic deformation and rebound of an element disposed on the collecting chamber upon interaction with an element disposed on the lid edge, andwherein the sound indicates formation of a liquid tight seal of the opening and the start of a detection assay by the detecting element when in use, and wherein a detection result is displayed on the detecting element after an allotted time starting from the generation of the sound.2. The device of claim 1 , wherein the element disposed on the lid edge is non-elastic and the element disposed on the collecting chamber is elastic.3. The device of claim 2 , wherein the lid and the collecting chamber are in rotatable engagement via a threaded connection.4. The device of claim 3 , wherein rotational movement of the lid with respect to the collecting chamber causes the sound to be generated upon contact of the element disposed on the collecting chamber with the lid edge after elastic deformation of the element disposed on the collecting ...

Hydrophilic Film, Preparation Method and Applications Thereof

The present invention provides a hydrophilic film that causes a liquid to diffuse rapidly in a single direction. The hydrophilic film comprises a substrate having a texture of parallel sunken and raised patterns, and a hydrophilic coat comprising a coat of silicon dioxide particles. The present invention also provides a method for preparing the hydrophilic film. The method comprises: preparing an aqueous dispersion of silicon dioxide particles, wherein the average size of the silicon dioxide particles is 1 to 60 nm, and the concentration of the silicon dioxide particles is 0.05% to 15% by weight; coating the aqueous dispersion of silicon dioxide particles on a substrate, wherein the substrate has a texture of parallel sunken and raised patterns; and drying the substrate coated with the aqueous dispersion of silicon dioxide particles.

DISPOSABLE ANALYTICAL MICROPROCESSOR DEVICE

The present invention generally relates to the determination of an analyte concentration (quantitative determination) or whether an analyte threshold level has been passed (qualitative determination) in a biological sample through employment of a disposable analytical microprocessor device. The device can include a batch-specific, self-executable algorithm for the calculation of the analyte concentration. 1. A disposable analytical microprocessor device capable of reversible engagement with a sensing meter such that said disposable analytical microprocessor device and said sensing meter are capable of bidirectional transfer of date , and said disposable analytical microprocessor device further comprises;a) at least one stored batch-specific disposable consumable parameter value;b) a microprocessor; andc) at least one self-executable algorithm able to calculate an analyte concentration value using date received from the sensing meter in combination with said stored batch-specific date, and transfer said value to said sensing meter.2. The device of wherein said device comprises a one-chip microcomputer which comprises said microprocessor.3. The device as recited in wherein said reversible engagement serial claim 1 , parallel claim 1 , or a combination thereof claim 1 , bidirectional transfer of said data.4. The device as recited in wherein said reversible engagement provides electrical connectivity and further provides said microprocessor with a clock pulse from an oscillator in said sensing meter.5. The device as recited in wherein said reversible engagement is optical and enables serial claim 1 , parallel claim 1 , or a combination thereof claim 1 , bidirectional transfer of said data.6. The device as recited in wherein said self-executable algorithm is based on a reference table conversion claim 1 , or on a mathematical function approximation wherein said mathematical function is selected from the group comprised of: a linear function claim 1 , a polynomial ...

Method and Device for Detecting an Analyte in a Body Fluid

A method for detecting at least one analyte in at least one sample of a body fluid is disclosed. Therein, at least one test element () is used, the at least one test element () having at least one test field () with at least one test chemistry () is used, wherein the test chemistry () is adapted to perform at least one optically detectable detection reaction in the presence of the analyte. The method comprises acquiring an image sequence of images of the test field () by using at least one image detector (). Each image comprises a plurality of pixels. The method further comprises detecting at least one characteristic feature of the test field () in the images of the image sequence. The method further comprises correcting a relative position change between the image detector () and the test field () in the image sequence by using the characteristic feature, thereby obtaining a sequence of corrected images. 1. A method for detecting at least one analyte in at least one sample of a body fluid , wherein at least one test element with at least one test field is used , the at least one test field having at least one test chemistry , wherein the test chemistry is adapted to perform at least one optically detectable detection reaction in the presence of the analyte , wherein the method comprises acquiring an image sequence of images of the test field by using at least one image detector , wherein each image comprises a plurality of pixels , wherein the method further comprises detecting using a control unit at least one characteristic feature of the test field in the images of the image sequence , wherein the method further comprises correcting using the control unit a relative position change between the image detector and the test field in the image sequence by using the characteristic feature.2. The method according to claim 1 , wherein the detecting of the characteristic feature comprises selecting at least one specific part of one or more images of the image sequence ...

Embossed Cell Analyte Sensor and Methods of Manufacture

An analyte measurement system is provided having sensors with embossed test chamber channels. In one embodiment, the sensors are elongate test strips for in vitro testing, each test strip having a substrate, at least one electrode, an embossed channel in the electrode, and lidding tape covering at least a portion of the embossed channel. Methods of manufacture are also disclosed for filling the sensor channels with reagent, and for trimming the ends of the sensors to eliminate the need for a calibration code during use of the sensors with a meter. 112-. (canceled)13. A method of manufacturing a plurality of analyte sensor having similar operating characteristics , the method comprising:forming a plurality of substantially functional analyte sensors connected to one another, each sensor having a channel extending to an edge of the sensor;separating a first analyte sensor from the plurality of analyte sensors;testing the first sensor to determine a calibration parameter of the sensor;based on the calibration parameter of the tested sensor, trimming a predetermined amount from one or more of the edges of the plurality of the non-tested sensors simultaneously, thereby changing a calibration parameter of the plurality of sensors; andseparating the plurality of connected functional analyte sensors into individual analyte sensors.14. The method of claim 13 , wherein trimming comprises reducing a sample volume of one or more channels of each of the plurality of functional analyte sensors.15. The method of claim 14 , wherein the channels extend perpendicular to the longitudinal axis of the sensor.16. The method of claim 15 , wherein the channel is completely covered by a substrate.17. The method of claim 14 , wherein the channels extend longitudinally along the sensors.18. The method of claim 14 , further comprising embossing the channels prior to forming the plurality of substantially functional analyte sensors.19. The method of claim 13 , further comprising:forming ...

Methods of Evaluating Medical Measurement Curves, as Well as Computer Programs and Devices Therefor

Methods are provided for detecting an analyte concentration/presence in a body fluid sample that include providing a set of at least two different evaluation rules, each evaluation rule adapted to derive a set characteristic values from an optical measurement curve, where at least one first characteristic value is derived from at least one first evaluation rule and at least one second characteristic value is derived from at least one second evaluation rule. The methods also include performing at least one multivariate analysis of the at least one first and second characteristic values by using at least one predetermined multivariate evaluation algorithm to derive at least one estimate value for at least one target variable Y of the state variables. The methods also include determining at least one analyte concentration by using the at least one target variable Y. Also provided are computer programs and devices that incorporate the same. 1. A method for determining at least one analyte concentration in a body fluid sample , the method comprising the steps of:a) obtaining, using a measuring unit, a plurality of measurement values that each indicate a progress of a detection reaction of at least one test substance and at least one body fluid sample at differing points in time, wherein the detection reaction is influenced by a set of state variables, each state variable characterizing at least one of a state of the body fluid sample and a condition of the detection reaction;b) generating, using at least one processor, at least one optical measurement curve, wherein the optical measurement curve contains the plurality of measurement values;{'sub': i', 'I=1 . . . N, 'c) providing, using the at least one processor, a set of at least two different evaluation rules, each evaluation rule adapted to derive a characteristic value from the optical measurement curve, thereby deriving a set of characteristic values X={X}from the optical measurement curve, the set of characteristic ...

Pairing And Synchronizing A Mobile Phone Application With A Handheld Glucose Meter

A diabetes management system includes a handheld medical device, a mobile computing device, and a diabetes management application. The handheld medical device is configured to determine, in response to a port receiving a test strip, whether an auto-send feature is enabled on the handheld medical device, determine whether the handheld medical device is paired with a mobile computing device, and selectively instruct a wireless transceiver to establish a wireless connection and communicate a glucose measurement and identifying information to the mobile computing device. The mobile computing device is configured to execute the diabetes management application. The diabetes management application is configured to process a plurality of glucose measurements and identifying information associated with each of a plurality of glucose measurements. 120.-. (canceled)21. A diabetes management system , comprising: a port configured to receive a test strip, the test strip having a reaction site for receiving a sample of fluid from a patient;', 'a measurement module cooperatively operable with a test strip inserted in the port and configured to measure glucose in a sample of fluid on the test strip;', 'a wireless transceiver; and', 'a communication module interfaced with the measurement module and cooperatively operable with the wireless transceiver, the communication module is configured to determine whether the handheld medical device is paired with a mobile computing device and, in response to a determination that the handheld medical device is paired with the mobile computing device, communicate the glucose measurement to the mobile computing device;', 'wherein the communication module is configured to determine whether a sync time feature is enabled and, in response to a determination that the handheld medical device is paired with the mobile computing device and a determination that the sync time feature is enabled, synchronize time on the handheld medical device with a time ...

SYSTEMS AND METHODS FOR MONITORING OF FRACTIONAL GLUCONEOGENESIS AND TARGETING OF FRACTIONAL GLUCONEOGENESIS VIA NUTRITIONAL SUPPORT

Systems, techniques and methods for estimating the metabolic state or flux, e.g., the body energy state (“BES”) of a patient, are disclosed. The BES provides a deep insight into the nutritional needs of the patient, thus allowing for a sort of exquisite glycemic control with regard to the patient. The invention discloses systems and methods for estimating fractional gluconeogenesis. The invention also discloses systems and methods for estimating and targeting patient blood lactate concentration, both as a target itself and as an intermediate step to estimating and targeting patient fractional gluconeogenesis glucose production. Nutritional support methods and formulations are also disclosed. The invention is suitable for any sort of patient, including those who are injured, such as with traumatic brain injury, ill, or have other conditions that stress the metabolic system. 1. A method of addressing the nutritional status of a patient , the method comprising:receiving a fractional gluconeogenesis value or set of values from one or more mass spectrometric readings from a blood sample from the patient, the value or set of values received directly, or indirectly over a network, from one or more mass spectrometric instruments; andadministering, if the fractional gluconeogenesis received is above about 15-30%, a nutritional support to the patient.2. The method of wherein the administering is carried out only if the fractional gluconeogenesis is above about 20-25%.3. The method of wherein the nutritional support comprises one or more salts.4. The method of wherein the nutritional support comprises lactate or pyruvate or both.5. The method of wherein the nutritional support comprises one or more of the following: glycerol claim 1 , glycerol tri-lactate claim 1 , glycerol tri-acetate claim 1 , arginyl lactate claim 1 , lactate N-acetylcysteine ester claim 1 , pyruvate claim 1 , acetoacetate claim 1 , or beta-hydroxy butyrate.6. The method of wherein the method further ...

Electrochemical Sensor System

An electrochemical sensor system comprises an electrochemical sensor and a hydrogel composition. The electrochemical sensor has at least a counter electrode and a working electrode. The hydrogel composition contacts the working electrode. The hydrogel composition comprises a first monomer, a second monomer, a cross-linking agent, and a solvent. The first monomer has hydrophilic characteristics. The second monomer has hydrophobic characteristics. The ratio of the first monomer to the second monomer is from about 0.1:99.9 to about 99.9:0.1. 171-. (canceled)73. The method of claim 72 , wherein the ratio of the first monomer to the second monomer is from about 40:60 to about 60:40.74. The method of claim 72 , wherein the analyte is glucose.75. The method of claim 72 , wherein the sensor is an electrochemical sensor.76. The method of claim 72 , wherein the first monomer is N-vinyl pyrrolidone.77. The method of claim 72 , wherein the first monomer is N-vinyl caprolactam.78. The method of claim 72 , wherein the first monomer is N-vinyl pyrrolidone claim 72 , the second monomer of Formula II being a (C-C)alkyl that is optionally substituted.79. The method of claim 78 , wherein the first monomer is N-vinyl pyrrolidone claim 78 , the second monomer of Formula II being N-vinyl butyramide claim 78 , N-vinyl valeramide claim 78 , N-vinyl lauramide claim 78 , or N-vinyl 4-chlorobutyramide.80. The method of claim 72 , wherein the second monomer of Formula II is N-vinyl butyramide claim 72 , N-vinyl valeramide claim 72 , N-vinyl lauramide claim 72 , or N-vinyl 4-chlorobutyramide.81. The method of claim 72 , wherein the first monomer is N-vinyl caprolactam claim 72 , the second monomer of Formula II being a (C-C)alkyl that is optionally substituted.82. The method of claim 81 , wherein the first monomer is N-vinyl caprolactam claim 81 , the second monomer of Formula II being N-vinyl butyramide claim 81 , N-vinyl valeramide claim 81 , N-vinyl lauramide claim 81 , or N-vinyl 4- ...

Apparatus and method for quantifying binding and dissociation kinetics of molecular interactions

The present invention relates to an apparatus for quantifying the binding and dissociation kinetics of molecular interactions of small molecular bio materials with high sensitivity almost without the influence of a change in the reflective index resulting from a buffer solution by making polarized incident light incident on the binding layer of a bio material, formed in a thin dielectric film, so that the polarized incident light satisfies a p-wave non-reflecting condition and a quantifying method using the same.

Impedance spectroscopy based systems and methods

One aspect of the invention provides a device that non-invasively determines the concentration of a substance in a target. The device includes a first electrode, a measuring circuit, and a data processor. In one embodiment of the device, the first electrode can be electrically insulated from the target, e.g., a cover layer of insulating material covers the first electrode.

Multiplexed active biologic array

A method of addressing and driving an electrode array includes the step of addressing one or more electrodes within the array using a plurality of row and column lines. In one aspect of the method, a value corresponding to a voltage is stored in a local memory associated with each electrode. The addressed electrodes are then driven at the voltages corresponding to the stored values. In another aspect of the method, a driving element associated with each addressed electrode is selectively coupled with a voltage line so as to charge the electrode with the voltage on the voltage line. The device and methods may be used in the synthesis of biopolymers such as oligonucleotides and peptides.

Glucose measuring device for use in personal area network

A glucose measuring system includes a glucose meter that incorporates wireless communication capabilities. The meter can advantageously be a low cost meter by eliminating expensive components, such as the display. The user nevertheless is able to retrieve and view his or her glucose values by referring to displays within the glucose measuring local area network. Feedback via these displays can advantageously be used by the diabetic to create a higher level of confidence and safety.

Minimum procedure system for the determination of analytes

A method for determining the presence of an analyte in a fluid is described along with various components of an apparatus specifically designed to carry out the method. The method involves taking a reflectance reading from one surface of an inert porous matrix impregnated with a reagent that will interact with the analyte to produce a light-absorbing reaction product when the fluid being analyzed is applied to another surface and migrates through the matrix to the surface being read. Reflectance measurements are made at two separate wavelengths in order to eliminate interferences, and a timing circuit is triggered by an initial decrease in reflectance by the wetting of the surface whose reflectance is being measured by the fluid which passes through the inert matrix. The method and apparatus are particularly suitable for the measurement of glucose levels in blood without requiring separation of red blood cells from serum or plasma.

Means for measuring a characteristic in a sample fluid

A measuring device, intended for measurements on whole blood, comprises a sample fluid chamber for containing a blood sample, ion-selective potentiometric electrodes for measurement of the concentrations of sodium and potassium ions, a reference potentiometric electrode, an optical sensor for measuring the concentration of glucose by means of a color reaction, a cuvette having a window permitting spectrophotometric measurement of the level of haemoglobin, a conditioning (calibration) fluid chamber in which the ion-selective electrodes and the reference electrode are exposed to a conditioning (calibration) fluid comprising known concentrations of sodium and potassium ions (thereby facilitating calibration of the response of the ion-selective electrodes), a rupturable pack containing the conditioning fluid and from which the fluid is released into the conditioning fluid chamber upon application of pressure to the pack, and a wall part which partly defines the sample fluid chamber and has weakened areas which are ruptured upon movement of the sensors (i.e. the electrodes and the glucose sensor) so as bring the sensors into contact with the blood sample and which establishes a seal around the sensors.

Minimum procedure system for the determination of analytes

A method for determining the presence of an analyte in a fluid is described along with various components of an apparatus specifically designed to carry out the method. The method involves taking a reflectance reading from one surface of an inert porous matrix impregnated with a reagent that will interact with the analyte to produce a light-absorbing reaction product when the fluid being analyzed is applied to another surface and migrates through the matrix to the surface being read. Reflectance measurements are made at two separate wavelengths in order to eliminate interferences, and a timing circuit is triggered by an initial decrease in reflectance by the wetting of the surface whose reflectance is being measured by the fluid which passes through the inert matrix. Repeatability is insured by a normalization technique performed on the light source before each reading, and an alignment method operated on the reagent strip prior to emplacement on the apparatus. The method and apparatus are particularly suitable for the measurement of glucose levels in blood without requiring separation of red blood cells from serum or plasma.

Glucose measuring device for use in personal area network

A glucose measuring system includes a glucose meter that incorporates wireless communication capabilities. The meter can advantageously be a low cost meter by eliminating expensive components, such as the display. The user nevertheless is able to retrieve and view his or her glucose values by referring to displays within the glucose measuring local area network. Feedback via these displays can advantageously be used by the diabetic to create a higher level of confidence and safety.

Glucose measuring device for use in personal area network

A glucose measuring system includes a glucose meter that incorporates wireless communication capabilities. The meter can advantageously be a low cost meter by eliminating expensive components, such as the display. The user nevertheless is able to retrieve and view his or her glucose values by referring to displays within the glucose measuring local area network. Feedback via these displays can advantageously be used by the diabetic to create a higher level of confidence and safety.

Glucose measuring device for use in personal area network

A glucose measuring system includes a glucose meter that incorporates wireless communication capabilities. The meter can advantageously be a low cost meter by eliminating expensive components, such as the display. The user nevertheless is able to retrieve and view his or her glucose values by referring to displays within the glucose measuring local area network. Feedback via these displays can advantageously be used by the diabetic to create a higher level of confidence and safety.

Control and calibration solutions and methods for their use

Control and calibration solutions are described that provide control and calibration data that is recognized by a test meter allowing the meter to segregate the control and calibration data from regular test data. Recognition and segregation of the control and calibration data can occur automatically with no additional input from the meter's user. Methods for use of the solutions are also provided.

Multiplexed active biologic array

An improved biologic electrode array (12) and methods for using the same. Each electrode (30) in the array (12) is coupled to a respective sample-and-hold circuit (26). The electrodes (30) and sample-and-hold circuits (26) are integral and form an array (12) within a single semiconductor chip, such that each sample-and-hold circuit (26) may be loaded (37) with a predefined voltage provided by a single, time-shared digital-to-analog converter (DAC) (22). All of the sample-and-hold circuits (26) may be accessed through a multiplexer which may scan through some or all of the electrode locations (30). Each sample-and-hold circuit (26) may comprise a capacitor (32) and one or more transistor switches (34, 36), the switches (34, 36), when closed providing electrical communication between the capacitor (32) and a source line (37) formed in the matrix (12).

Method and system to provide personalized pharmaceutical compositions and dosages

The invention provides a method for determining a suitable drug combination for the treatment of Type 2 diabetes by obtaining data from a Type 2 diabetes population in which all of the Type 2 diabetics are not taking any Type-2 diabetes drugs and obtaining reference levels of glucose supply and insulin demand parameters. Data from discrete samples of Type 2 diabetes populations in which all individuals are being treated with one or more Type 2 diabetes drugs at a therapeutic dose are also obtained, and the effects of the drugs on the glucose supply and insulin demand parameters are used to determine adjustment factors which represent the effect of each of the drugs at the therapeutic dosage, which are used to determined a ratio of a Glucose Supply Index (S) to an Insulin Demand Index (D). The ratio is further utilized in scoring cardiovascular risks for Type 2 diabetics and recommending therapeutic interventions.

Fluid injection and safety system

Various medical systems and methods are described, including a medical monitoring system ( 102, 400, 700, 800, 2632). The medical monitoring system can have a fluid system (404, 510. 801, 901) configured to receive bodily fluid and optically analyze said fluid to determine analyte concentration. The fluid system can have a removable portion (408, 410, 710, 804. 904. 1000, 4218). The removable portion can have an opening with a port (3912, 3916. 4216). The system can also have a container (2812, 3112) configured to contain anticoagulant. The container can have a portion configured to mate with the port of the removable portion. The container can be further configured to not fit into a conventional luer fitting. An anti-coagulant insertion apparatus is also described. The apparatus can have a syringe (2812). a dock (3912) with a port (3916, 4216), and an adapter (3312, 2814) configured to connect the syringe to the port. The dock can also have a tab (3918) configured to move with the port.

Method and device for providing offset model based calibration for analyte sensor

Methods and devices to detect analyte in body fluid are provided. Embodiments include processing sampled data from analyte sensor, determining a single, fixed, normal sensitivity value associated with the analyte sensor, estimating a windowed offset value associated with the analyte sensor for each available sampled data cluster, computing a time varying offset based on the estimated windowed offset value, and applying the time varying offset and the determined normal sensitivity value to the processed sampled data to estimate an analyte level for the sensor.

Methods for using an analyte testing device

A test unit cartridge for holding a plurality of test units includes a first test unit that contains a first analyte sensor and a second test unit that contains a second analyte sensor. The first and second analyte sensors use first and second reagents to detect first and second analytes, respectively. The first analyte is different from the second analyte and the first and second test units are functionally non-fungible. The plurality of test units can also include a third test unit that contains two analyte sensors having two reagents for detecting two different analytes using one fluid sample. A method of using the test unit cartridge is also described, which comprises loading the cartridge into an analyte testing device and cocking an actuator of the device that is configured to (i) expose an analyte sensor of a test unit, (ii) ready a lancet, and (iii) advance a lancet cartridge.

Multiplexed active biologic array

본 발명은 개선된 바이오로직 전극 어레이(12) 및 이를 사용하기 위한 방법이다. 어레이(12) 내의 각 전극(30)은 각각의 샘플 앤드 홀드 회로(26)에 결합된다. 전극(30) 및 샘플 앤드 홀드 회로(26)는, 각각의 샘플 앤드 홀드 회로(26)가 단일 시분할 디지탈/아날로그 변환기(DAC)(22)에 의해서 제공된 선정된 전압으로 (37)을 로드시킬 수 있도록, 단일 반도체 칩 내에 어레이(12)를 집적화시켜 형성된다. 모든 샘플 앤드 홀드 회로(26)는 일부 또는 전체 전극 위치부(30)를 통해서 스캔될 수 있는 멀티플렉서를 통해서 액세스될 수 있다. 각각의 샘플 앤드 홀드 회로(26)는 캐패시터(32) 및 하나 이상의 트랜지스터 스위치(34, 36)를 포함하며, 상기 스위치(34, 36)가 닫힐 때 매트릭스(12) 내에 형성된 캐패시터(32)와 소스 선(37) 사이에 전기적으로 접속시킨다. The present invention is an improved biologic electrode array 12 and a method for using the same. Each electrode 30 in the array 12 is coupled to a respective sample and hold circuit 26. Electrode 30 and sample and hold circuit 26 allow each sample and hold circuit 26 to load 37 with a predetermined voltage provided by a single time division digital / analog converter (DAC) 22. In such a way, it is formed by integrating the array 12 in a single semiconductor chip. All sample and hold circuits 26 can be accessed through a multiplexer, which can be scanned through some or all electrode positions 30. Each sample and hold circuit 26 includes a capacitor 32 and one or more transistor switches 34 and 36, the capacitor 32 and the source formed in the matrix 12 when the switches 34 and 36 are closed. The wires 37 are electrically connected to each other. 바이오로직 어레이 Biologic Array

Test unit cartridge for alalyte testing device

다수의 검사 유닛을 보유하는 검사 유닛 카트리지는 제 1 분석 물질 센서를 포함하는 제 1 검사 유닛과, 제 2 분석 물질 센서를 포함하는 제 2 검사 유닛을 포함한다. 제 1 및 제 2 분석 물질 센서는 각각 제 1 및 제 2 분석 물질을 검출하기 위한 제 1 및 제 2 시약을 이용한다. 제 1 분석 물질은 제 2 분석 물질과 다르며, 제 1 및 제 2 검사 유닛은 기능적으로 대체 불가능하다. 다수의 검사 유닛은 하나의 유체 샘플을 이용하여 2개의 서로 다른 분석 물질을 검출하는 2개의 시약을 가진 2개의 분석 물질 센서를 포함하는 제 3 검사 유닛을 또한 포함할 수 있다. 검사 유닛 카트리지를 이용하는 방법이 설명되는 데, 그 방법은 분석 물질 검사 장치에 카트리지를 탑재하고; (ⅰ) 검사 유닛의 분석 물질 센서를 노출시키고, (ⅱ) 랜싯을 준비하고, (ⅲ) 랜싯 카트리지를 이동시키도록 구성된 장치의 액튜에이터를 코킹하는 것을 구비한다. An inspection unit cartridge having a plurality of inspection units includes a first inspection unit including a first analyte sensor and a second inspection unit including a second analyte sensor. The first and second analyte sensors use first and second reagents for detecting the first and second analyte, respectively. The first analyte is different from the second analyte, and the first and second examining units are functionally non-replaceable. The plurality of inspection units may also comprise a third inspection unit comprising two analyte sensors with two reagents for detecting two different analytes using one fluid sample. A method of using an inspection unit cartridge is described, the method comprising: loading a cartridge into an analyte testing apparatus; (I) exposing the analyte sensor of the inspection unit, (ii) preparing the lancet, and (iii) caulking the actuator of the apparatus configured to move the lancet cartridge.

Use of conductive sensors in diagnostic assays

A conductive sensor and its use in a diagnostic assay are disclosed. The miniaturized conductive sensor, utilizing a conducting polymer, is used in a diagnostic device to determine the presence or concentration of a predetermined analyte in a liquid test sample, wherein the predetermined analyte, like glucose, is assayed by an oxidase interaction. The interaction between the oxidase and a small amount of the predetermined analyte in the test sample generates, either directly or indirectly, a dopant compound in a reaction zone of the conductive sensor. The dopant compound then migrates to the detection zone of the conductive sensor of the diagnostic device to oxidize the conducting polymer and convert the conducting polymer from an insulating form to a conducting form. The resulting increase in conductivity of the conducting polymer is measured, then the conductivity increase is correlated to the concentration of the predetermined analyte in the test sample.

Polymeric luminophores for sensing of oxygen

The present invention relates to polymeric luminophores which contain ruthenium, osmium, and rhenium complexes covalently attached to polymer matrices. The polymeric luminophores are capable of having their luminescence quenched by molecular oxygen and may be coated on optical fibers to form sensing elements to detect oxygen in gases and fluids.

System and method for determining an abused sensor during analyte measurement

A method of measuring an analyte in a biological fluid comprises applying an excitation signal having a DC component and an AC component. The AC and DC responses are measured; a corrected DC response is determined using the AC response; and a concentration of the analyte is determined based upon the corrected DC response. Other methods and devices are disclosed.

具有可替换样品收集芯片的化学品传感器

本发明涉及具有可替换样品收集芯片的化学品传感器。一种化学品传感器被提供在第一半导体裸片上。稳压器被提供在第二半导体裸片上。模数转换器和微控制器被提供在第三半导体裸片上。第一裸片被配置为连接至第二裸片。第二裸片被配置为连接至第三裸片。化学品传感器检测周围环境中的化学品并且输出信号至模数转换器。模数转换器将该信号转换为数字信号并且输出该数字信号至微控制器。微控制器提供周围环境中的化学品浓度的测量。

Instrument

A method and apparatus for performing a first measurement on a biological fluid or control, which first measurement varies with both the concentration of a first component and at least one of the presence and concentration of a second component. The method and apparatus perform a second measurement on the biological fluid or control, which second measurement varies primarily only with the at least one of the presence and concentration of the second component to develop an indication of the at least one of the presence and concentration of the second component. The first and second measurements may be made sequentially or simultaneously. The method and apparatus then remove an amount representative of the indicated presence or concentration of the second component from the concentration of the first component indicated by the first measurement.

Устройства и способы для отбора проб и измерения компонента биологической жидкости

2002115719 А ко РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ, ПАТЕНТАМ И ТОВАРНЫМ ЗНАКАМ <: м 77 & ВО” 2002 д 7 Х р 7 72 27 > > 2% 2 51) МК’ С 01 М 33/487 (12 ИЗВЕЩЕНИЯ К ЗАЯВКЕ НА ИЗОБРЕТЕНИЕ (21), (22) Заявка: 2002115719/14, 11.06.2002 (30) Конвенционный приоритет: 12.06.2001 Ц$ 09/879,188 (43) Дата публикации заявки: 20.01.2004 Адрес для переписки: 129010, Москва, ул. Б.Спасская, 25, стр.3, ООО "Юридическая фирма Городисский и Партнеры", пат.пов. Г.Б. Егоровой (71) Заявитель(и): ЛАЙФСКЕН, ИНК. (Ц5$) (72) Автор(ы): ШАРТЛ Роберт (0$), ЛЕОНГ Коон-вах (1$), КАЙСЕР Эрнест (ЦЗ) (74) Патентный поверенный: Егорова Галина Борисовна (54) Устройства и способы для отбора проб и измерения компонента биологической жидкости ГАЭА - Признание заявок на изобретение отозванными в связи с непредставлением в установленный срок ходатайства о проведении экспертизы заявки по существу Дата отзыва заявки: 14.07.2006 Извещение опубликовано: 27.08.2006 БИ: 24/2006 Страница: 1 бя о00Сс ПЧ А"

测定血液中葡萄糖浓度的方法

公开了一种基于测量患者皮肤总阻抗的非侵入式测定血液中葡萄糖浓度的方法，该方法是基于葡萄糖浓度与总阻抗之间呈一阶相关性的线性模型，并且该模型考虑了葡萄糖浓度的变化速率。使用侵入式方法在测量初始阶段测定了近似函数中使用的系数。

用于检测分析物的对称测试元件

公开了一种用于检测体液中的至少一种分析物的测试元件（114），具体地用于检测体液中的葡萄糖。测试元件（114）包括至少一个条状载体元件（126）和具有用于检测分析物的至少一种测试化学成分（124）的至少一个测试场（122）。测试元件（114）具有对称形状，使得可以至少两个不同取向将测试元件（114）插入测试设备（112）的测试元件容器（118）中。测试设备（112）具有检测设备（130）。在不同取向上，测试场（122）的测试化学成分（124）的至少一种分析物引发变化是可检测的。

Method for revealing differences between blood and reference solution, containing same analysed substance

FIELD: medicine. SUBSTANCE: there is involved revealing differences between measurement of the analysed substance level in blood samples and measurement of the analysed substance level in reference solutions used for testing of optical devices used to perform these measurements. The reference solution contains: a marking substance revealed by the optical device to distinguish measurements, e.g., of glucose level received for the reference solutions from measurements of glucose level received for biological fluid sample, e.g., blood. EFFECT: use of the invention allows revealing differences between measurements of the analysed substance level in blood and reference solutions. 2 ex, 2 dwg РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) 2 401 429 (13) C2 (51) МПК G01N 33/50 G01N 33/96 (2006.01) (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ, ПАТЕНТАМ И ТОВАРНЫМ ЗНАКАМ (12) ОПИСАНИЕ ИЗОБРЕТЕНИЯ К ПАТЕНТУ (21), (22) Заявка: 2007126675/15, 12.12.2005 (24) Дата начала отсчета срока действия патента: 12.12.2005 (73) Патентообладатель(и): БАЙЕР ХЕЛТКЭР ЛЛК (US) R U (30) Конвенционный приоритет: 13.12.2004 US 60/635,573 (72) Автор(ы): МАРФУРТ Карен Л. (US) (43) Дата публикации заявки: 20.01.2009 2 4 0 1 4 2 9 (45) Опубликовано: 10.10.2010 Бюл. № 28 2 4 0 1 4 2 9 R U (85) Дата перевода заявки PCT на национальную фазу: 13.07.2007 (86) Заявка PCT: US 2005/045234 (12.12.2005) (87) Публикация PCT: WO 2006/065899 (22.06.2006) Адрес для переписки: 103735, Москва, ул.Ильинка, 5/2, ООО "Союзпатент", пат.пов. Ю.Б.Перегудовой, рег. № 1103 (54) СПОСОБ ВЫЯВЛЕНИЯ РАЗЛИЧИЯ МЕЖДУ КРОВЬЮ И КОНТРОЛЬНЫМ РАСТВОРОМ, СОДЕРЖАЩИМИ ОДИНАКОВОЕ АНАЛИЗИРУЕМОЕ ВЕЩЕСТВО (57) Реферат: Изобретение относится к области медицины, в частности к лабораторным методам исследования. Сущность изобретения заключается в том, что проводится выявление различий между измерением уровня анализируемого вещества в пробах крови и измерением уровня анализируемого вещества в контрольных растворах, используемых для ...

Analyte sensor with embossed cell and method of manufacture

FIELD: measuring equipment. SUBSTANCE: in one implementation version, the sensors are elongated test-strips for testing in vitro, wherein each test-strip has a substrate, at least, one electrode, a channel embossed in the electrode, and a covering tape covering, at least, a part of the embossed channel. EFFECT: method enables to eliminate the need for the calibration code when using sensors with the measuring device. 10 cl, 6 dwg С 2 2625769 ко РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) (11) а за ва ва г (13) (51) МПК ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ СОМ 33/487 (2006.01) (12) ОПИСАНИЕ ИЗОБРЕТЕНИЯ К ПАТЕНТУ (21)(22) Заявка: 2012120483, 17.05.2012 (24) Дата начала отсчета срока действия патента: 16.10.2007 Дата регистрации: 18.07.2017 Приоритет(ы): (30) Конвенционный приоритет: 24.10.2006 95 11/552,234 Номер и дата приоритета первоначальной заявки, из которой данная заявка выделена: 2009115484 24.10.2006 (43) Дата публикации заявки: 27.11.2013 Бюл. № 33 (45) Опубликовано: 18.07.2017 Бюл. № 20 Адрес для переписки: 129090, Москва, ул. Б. Спасская, 25, строение 3, ООО "Юридическая фирма Городисский и Партнеры" (72) Автор(ы): ПЕТИТ Адриан (СВ), ГЕКТОР Саймон Эндрю (С@В) (73) Патентообладатель(и): ЭББОТ ДАЙАБИТИЗ КЭР, ИНК. (0$) (56) Список документов, цитированных в отчете о поиске: КУ 2258922 С2, 20.08.2005. 05 20060144704 АЛ, 06.07.2006. АРБАТСКАЯ Н.Ю. Современные приборы для самоконтроля уровня сахара крови, Лечащий врач, М 5, 2005г, онлайн [найдено из Интернет] [найдено 05.05.2015] ВЕр// мм! ДугасВ.ги/2005/05/4532531/. НЕАГЕУ ВС е{ а1., Миапа1уе Мозепзогз оп орИса1| 1та21тх Бип е$. В1озепз В1о@ес топ. 1997; М (см. прод.) (54) СЕНСОР АНАЛИТА С ТИСНЕНОЙ ЯЧЕЙКОЙ И СПОСОБ ИЗГОТОВЛЕНИЯ (57) Реферат: Изобретение относится к медицине и представляет собой способ изготовления системы измерения аналита, имеющей сенсоры с тиснеными каналами измерительной камеры. В одном варианте осуществления сенсоры являются удлиненными тест-полосками для тестирования ш уго, причем каждая ...

Urine test method and urine test apparatus used therefor

Method and device for detecting the analyte in body fluid

公开了一种用于检测至少一份体液样本中的至少一种分析物的方法。其中使用至少一个测试元件（124），所述至少一个测试元件（124）具有至少一个测试场（162），所述至少一个测试场（162）带有至少一种测试化学品（154），其中所述测试化学品（154）被适配成在有分析物存在的情况下实施至少一种光学上可检测的检测反应。所述方法包括通过使用至少一个图像检测器（178）采集测试场（162）的图像的图像序列。每一幅图像包括多个像素。所述方法还包括检测所述图像序列的图像中的测试场（162）的至少一项特性特征。所述方法还包括通过使用所述特性特征校正图像序列中的图像检测器（178）与测试场（162）之间的相对位置改变，从而获得经过校正的图像序列。

Integrated meter for analyzing biological samples

Analyte monitoring devices and methods therefore are provided. The devices integrate various functions of analyte monitoring, e.g., sample acquisition and testing.

Method and device for determining an analyte in physiological fluid

FIELD: medicine; measurement technology. SUBSTANCE: invention relates to determination of analyte in physiological fluid sample. Method uses a test element having test field with analytical reagent, suitable for optically detectable analytical reaction in the presence of an analyte. Method involves obtaining a sequence of test field images by means of image receiver. Each image includes a plurality of pixels. According to the method, detection is performed in the images belonging to sequence of the images, characteristic attribute of the test field, taking it into account, change correction of relative position of the image receiver and the test field is performed. Images corrected in this way enable to observe change optically detected property of the test field occurring as a result of analytical reaction of a reagent with an analyte. EFFECT: high accuracy and significant degree of eliminating artefacts and inaccuracies for evaluation of very small sample volume. 20 cl, 24 dwg РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (51) МПК G01N 21/84 (13) 2 604 166 C2 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ОПИСАНИЕ (21)(22) Заявка: ИЗОБРЕТЕНИЯ К ПАТЕНТУ 2015101752/28, 17.06.2013 (24) Дата начала отсчета срока действия патента: 17.06.2013 (72) Автор(ы): ДИКОПФ Кай (DE) (73) Патентообладатель(и): Ф.ХОФФМАНН-ЛЯ РОШ АГ (CH) Приоритет(ы): (30) Конвенционный приоритет: (43) Дата публикации заявки: 10.08.2016 Бюл. № 22 R U 22.06.2012 EP 12173121.0 (45) Опубликовано: 10.12.2016 Бюл. № 34 (85) Дата начала рассмотрения заявки PCT на национальной фазе: 22.01.2015 (86) Заявка PCT: 2 6 0 4 1 6 6 (56) Список документов, цитированных в отчете о поиске: EP 2270421 A1, 05.01.2011. US 2011201909 A1, 18.08.2011. EP 0974303 A1, 26.01.2000. EP 1359409 A2, 05.11.2003. 2 6 0 4 1 6 6 R U (87) Публикация заявки PCT: WO 2013/189880 (27.12.2013) Адрес для переписки: 105082, Москва, Спартаковский пер., д. 2, стр. 1, секция 1, этаж 3, ЕВРОМАРКПАТ (54) СПОСОБ И УСТРОЙСТВО ДЛЯ ...

Biological fluid constituent sampling and measurement devices and methods

생물학적 유체를 액세싱(access)하고, 생물학적 유체 성분을 샘플링한 다음, 액세싱된 생물학적 유체내 하나 이상의 표적 성분의 농도를 측정하기 위한 장치가 제공된다. 장치는 선택된 깊이로 피부를 천공시키고 생물학적 유체를 액세싱하기 위해 사용되는 하나 이상의 미세 천공 부재, 성분 샘플링 수단 및 성분 측정 수단을 갖는다. 성분 샘플링 수단은 샘플링된 성분을 미세 천공 부재로부터 측정 수단으로 운반하는 성분 운반 매질, 예를 들면, 친수성 겔 물질을 포함한다. 측정 수단은 하나 이상의 샘플링된 성분을 전기 화학적 셀로 도입시키는 하나 이상의 다공성 전극을 갖는 전기 화학적 셀을 포함한다. 피부 내 성분을 샘플링하고 샘플링된 성분을 측정하는 방법뿐만 아니라 본 발명을 수행하기 위한 키트가 제공된다.

Apparatus and method for quantifying binding and dissociation kinetics of molecular interactions

本发明涉及通过使偏振的入射光入射到在薄介电膜中形成的生物材料结合层上以使偏振的入射光满足p波非反射条件来以高灵敏度量化小分子生物材料的分子相互作用的结合和离解动力且几乎不受由缓冲溶液引起的折射率变化影响的装置以及使用该装置的量化方法。

Embossed cell analyte sensor and method of manufacture

FIELD: physics. SUBSTANCE: method of manufacturing a plurality of analyte sensors having similar operating characteristics involves steps for: forming a plurality of analyte sensors; testing at least one of the sensors to determine a calibration parameter of the sensor; based on the calibration parameter of the tested sensor, trimming the distal end of the non-tested sensors to reduce the area of the working electrode, thereby changing a calibration parameter of the sensors to a given value. Each sensor has a distal end having a working electrode and a channel. EFFECT: invention enables to calibrate analyte sensors relative a measuring device by eliminating the need for a calibration code when using sensors with the measuring device. 11 cl, 6 dwg РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) 2 461 002 (13) C2 (51) МПК G01N 33/487 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ОПИСАНИЕ ИЗОБРЕТЕНИЯ К ПАТЕНТУ (21)(22) Заявка: 2009115484/15, 16.10.2007 (24) Дата начала отсчета срока действия патента: 16.10.2007 (72) Автор(ы): ПЕТИТ Адриан (GB), ГЕКТОР Саймон Эндрю (GB) (73) Патентообладатель(и): ЭББОТ ДАЙАБИТИЗ КЭР, ИНК. (US) R U Приоритет(ы): (30) Конвенционный приоритет: 24.10.2006 US 11/552,234 (43) Дата публикации заявки: 27.10.2010 Бюл. № 30 2 4 6 1 0 0 2 (45) Опубликовано: 10.09.2012 Бюл. № 25 (56) Список документов, цитированных в отчете о поиске: US 2006/0144704 A1, 06.07.2006. EP 1482299 A1, 01.12.2004. WO 2004/083843 A1, 30.09.2004. RU 2258922 C2, 20.08.2005. 2 4 6 1 0 0 2 R U (86) Заявка PCT: US 2007/022100 (16.10.2007) C 2 C 2 (85) Дата начала рассмотрения заявки PCT на национальной фазе: 23.04.2009 (87) Публикация заявки РСТ: WO 2008/051407 (02.05.2008) Адрес для переписки: 129090, Москва, ул.Б.Спасская, 25, стр.3, ООО "Юридическая фирма Городисский и Партнеры", пат.пов. Ю.Д.Кузнецову, рег.№ 595 (54) СЕНСОР АНАЛИТА С ТИСНЕНОЙ ЯЧЕЙКОЙ И СПОСОБ ИЗГОТОВЛЕНИЯ (57) Реферат: Изобретение относится к области изготовления сенсоров аналита. Способ ...

Biological fluid constituent sampling and measurement devices

생물학적 유체에 접근하여 당해 생물학적 유체 성분을 샘플링한 다음, 접근한 생물학적 유체내 하나 이상의 표적 성분의 농도를 측정하기 위한 장치가 제공된다. 장치는 소정 깊이로 피부를 천공시키고 생물학적 유체에 접근하기 위해 사용되는 하나 이상의 미세 천공 부재, 성분 샘플링 수단 및 성분 측정 수단을 갖는다. 성분 샘플링 수단은 샘플링된 성분을 미세 천공 부재로부터 측정 수단으로 운반하는 성분 운반 매질, 예를 들면, 친수성 겔 물질을 포함한다. 측정 수단은 하나 이상의 샘플링된 성분을 전기 화학적 전지로 도입시키는 하나 이상의 다공성 전극을 갖는 전기 화학적 전지를 포함한다. 피부 내 성분을 샘플링하고 샘플링된 성분을 측정하는 방법뿐만 아니라 본 발명을 수행하기 위한 키트가 제공된다. 생물학적 유체, 미세 천공 부재, 성분 샘플링 수단, 성분 측정 수단, 전기 화학적 전지.

Method and test strip for determining glucose in blood

A reagent strip for measuring the concentration of glucose in whole blood has a polymer on at least one side thereof to increase the opacity thereof; thereby reducing the effect of hematocrit on the glucose determination.

Analyte concentration detection devices and methods

Arrangements for the detection of the presence and/or concentration of an analyte in a sample of bodily fluid include diffuse transmission, diffuse reflection and edge or waveguide illumination arrangements. A vertical flow assay arrangement and/or technique is also disclosed, and includes a detection component that can be in the form of an array of optical detection elements. A number of assay pad constructions are described which may include at least one or more of the following components: a prefilter component, a reflective component, a membrane component, a reagent component, a mesh component, and a component to prevent lateral spreading.

Test element with single-layer reaction film

Die Erfindung betrifft Testelemente und Verfahren zum optischen Nachweis eines Analyten in einer Probe. The invention relates to test elements and methods for the optical detection of an analyte in a sample.

Test strips

Patent DE2927345C2

TEST STRIPS FOR THE SIMULTANEOUS DETECTION OF SEVERAL ANALYSTS

Method and device for isolating microparticles from liquid mixture

Apparatus and a method of separating a particulate portion as defined herein from a mixture including a liquid portion, including introducing the mixture into a stream of wash solution flowing along an open bore of a conduit, the wash solution having immiscible fluid segments therein, and subsequent to a separating step, collecting at least one of the aforesaid portions. Combined with these steps is the step of permeating over a period of time the internal surface of the aforementioned conduit with at least the aforementioned liquid portion. This retards the flow of the liquid portion which progressively lags behind the particulate portion until the two portions are separated by the segmented wash solution. Either or both portions may be collected, and when collected, the particulates are in washed condition. The aforementioned separation may be achieved on-line in a sample analyzer, and either or both collected portions may be reacted on-line with a reactant, and at least one product of the reaction may be analyzed on-line.

Polysaccharide-containing block copolymer particles and uses thereof

The invention relates to new amphiphilic linear block copolymers of polysaccharides and polymers. The amphiphilic linear block copolymers do not form a true solution in water and are able to form micelles in selective solvents. Also disclosed are particles, each of which has a shell and a core, and a diameter of about 1 to 1,000 nanometers, and methods of delivering agents or removing substances, e.g., undesirable substances, from a subject or environment, by using these particles.

Indicator bar

Analyte concentration determination method

Ascorbate intrinsic detection method of hydrogen peroxide

본 발명은, 용액을 산화-환원 지시제 및 전이 금속 착물과 접촉시킴을 포함하여, 생물학적 체액 또는 수용액 중에서 과산화수소를 검출하는 방법에 관한 것이다. 전이 금속 착물은 철 배위의 크레아티닌 또는 철 배위의구아니딘이다.

System and program for chemical reaction observation with a moving photometer

System and program for measuring progressively the absorbance changes of a large number of aliquots from a plurality of different samples in a continuous processing mode. A plurality of routine samples are maintained in an ordered sequence in a sample tray which may be moved to a first sample pick up position. Emergency samples (stats) and controls (standards) are positioned in a second plurality of auxiliary positions which may be moved to a second sample position. A first and second plurality of reagents are maintained, moved to respective reagent pick up positions, picked up, moved and dispensed in respective dispensing positions by respective single reagent dispensing arms in a similar manner to the sample operation. The chemical reaction is then monitored by photometer means preferably having a plurality of photometric detectors such that radiation passes through each of the cuvettes and the fluids therein during each cycle of the system. Just prior to the sample dispensing position the cuvette is cleaned and tested to ensure that all the previously added fluids have been removed prior to receiving a new sample. Any one sample may be tested with different reagents or reagent mixtures in different aliquots placed in separate cuvettes at each wavelength as desired. Each sample aliquot and reagent mixture may be measured to determine the rate of the chemical reaction and the equilibrium or end point of the reaction or both, if desired. The array of cuvettes is continuous, because it is replenished at the end of each sequence prior to the addition of the new sample.

Flourescence intramolecular energy transfer conjugate compositions and detection methods

A variety of conjugated compositions and methods for the detection of an analyte of interest in a fluid sample is provided which relies upon an intramolecular energy transfer between a conjugated fluorophore and a chromophoric light-absorbing ligand for qualitative and quantitative results. The detection methods preferably employ fiber optic sensors in combination with analyte-insensitive fluorophores and analyte-sensitive absorber ligands in conjugated form. The methods and compositions rely upon the ability of the absorbing ligands to absorb energy which is transferred non-radiatively by the fluorophore when in an excited state.

Method for syncronizing time measured from apparatus for analyzing diagnosis strip

PURPOSE: The time synchronizing method of a diagnostic strip analyzer is provided to efficiently manage the data of a diagnostic strip analyzer by time synchronizing the measurement time data of the analyzer and a managing medium. CONSTITUTION: The time synchronizing method of a diagnostic strip analyzer includes the following: time setting information is saved in the saving part of a diagnostic strip analyzer if a time setting operation is implemented for the analyzer(S110); biometric information is measured based on the analyzer(S120); the time setting information, and the measured amount and the measured time of the biometric information are simultaneously saved in the saving part(S130); the time setting information, the measured amount and the measured time of the biometric information are transferred with the measured time of the biometric information to a managing medium(S140); the controlling part of the managing medium verifies whether the time setting operation of the analyzer is implemented(S150); and if the time setting operation of the analyzer is implemented, the time setting information, and the measured amount, the measured time, and the transferred time of the biometric information are saved in the saving part of the managing medium(S160).

Glucose Measuring Device For Use In Personal Area Network

A glucose measuring system includes a glucose meter that incorporates wireless communication capabilities. The meter can advantageously be a low cost meter by eliminating expensive components, such as the display. The user nevertheless is able to retrieve and view his or her glucose values by referring to displays within the glucose measuring local area network. Feedback via these displays can advantageously be used by the diabetic to create a higher level of confidence and safety.

Glucose Measuring Device For Use In Personal Area Network

A glucose measuring system includes a glucose meter that incorporates wireless communication capabilities. The meter can advantageously be a low cost meter by eliminating expensive components, such as the display. The user nevertheless is able to retrieve and view his or her glucose values by referring to displays within the glucose measuring local area network. Feedback via these displays can advantageously be used by the diabetic to create a higher level of confidence and safety.

Specimen measuring device protection apparatus and method

System and method for determining a sensor misused during measurement of an analyte in a biological fluid

Test element for determining a body fluid and measurement method

본 발명은, 체액에 민감한 시약으로 충전되는 검출 구역을 포함하는, 체액 결정용, 특히 혈당 레벨 결정용 시험 요소에 관한 것이다. 본 발명에 따르면, 검출 구역에 대한 적어도 하나의 상태 파라미터를 검출하기 위해 검출 구역 내에 및/또는 검출 구역 부근에 기능 요소가 배치되고, 상기 기능 요소는 상태 측정에 의해 평가될 수 있다. 또한, 본 발명은 시험 요소를 측정하는 방법에 관한 것이다. The present invention relates to test elements for the determination of bodily fluids, in particular for the determination of blood glucose levels, comprising a detection zone filled with reagents sensitive to bodily fluids. According to the invention, a functional element is arranged in and / or near the detection zone for detecting at least one state parameter for the detection zone, which functional element can be evaluated by state measurement. The invention also relates to a method of measuring test elements.

Condensate glucose analyzer

The present invention provides systems and methods for analyzing glucose present in exhaled breath condensate (EBC). In certain embodiments of the invention, electrochemical- or coulometric-based sensing technologies are used to analyze EBC for the presence and/or concentration of glucose.

Hand-held diagnostic instrument for measuring hematocrit with measuring loop based on phase shift

FIELD: measuring equipment. SUBSTANCE: invention relates to a hand-held diagnostic instrument to be used with the analytical test strips while determining glucose in blood, includes a body (110); a microcontroller unit (112) disposed in the body; and a hematocrit measuring unit based on the phase shift (114). The hematocrit measuring unit, based on the phase shift, includes a signal generating subunit (120), a low frequency filter subunit (122), a contact surface subunit for interacting in a cell while sampling analytical test strips (124), a transimpedance amplifier subunit (128) and a phase detector subunit (130). Furthermore, the hematocrit measuring unit based on the phase shift and the microcontroller unit are adapted to calculate a physiological fluid sample phase shift in the measuring cell of the analytical test strip placed in the hand-held diagnostic unit. The microcontroller unit is adapted to calculate the hematocrit level in the physiological fluid sample subject to the measured phase shift. EFFECT: device usage allows to determine accurately glucose in the blood drop. 21 cl, 7 dwg РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 2 616 518 C2 (51) МПК G01N 27/327 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ФОРМУЛА (21)(22) Заявка: ИЗОБРЕТЕНИЯ К ПАТЕНТУ РОССИЙСКОЙ ФЕДЕРАЦИИ 2014117497, 01.10.2012 (24) Дата начала отсчета срока действия патента: 01.10.2012 Дата регистрации: (72) Автор(ы): КРАФТ Ульрих (DE), ЭЛДЕР Дэвид (GB), КЕРМАНИ Махиар (US) Приоритет(ы): (30) Конвенционный приоритет: R U (73) Патентообладатель(и): ЛАЙФСКЭН СКОТЛЭНД ЛИМИТЕД (GB) 17.04.2017 (56) Список документов, цитированных в отчете о поиске: EP 1394545 A1, 03.03.2004. RU 30.09.2011 US 13/250,525 (45) Опубликовано: 17.04.2017 Бюл. № 11 (85) Дата начала рассмотрения заявки PCT на национальной фазе: 30.04.2014 2395086 C1, 20.07.2010. RU 2009101335 A, 27.07.2010. RU 2006144458 A, 20.06.2008. RU 2338242 C2, 10.11.2008. WO 2011047271 A1, 21.04.2011. (86) Заявка PCT: GB 2012/ ...

The blood glucose strip with low sensitivity to hematocrit

전혈중 글루코즈 농도를 측정하기 위한 시약 스트립(reagent strip)은 글루코즈 측정시 헤마토크릿의 간섭을 저하시킨다. 생물학적 유액이 스크립과 접촉하는 경우, 이것은 스트립중에 함침된 시약 중에서, 유액중 글루코즈 농도의 척도가 되는 색상 변화를 유발한다. 그러나, 색상 변화는 또한 적혈구 세포 농도(헤마토크릿: hematocrit)에 의해 영향받음으로써, 글루코즈 측정의 정확도를 떨어뜨린다. 헤마토크릿 효과는 시약에 아크릴산 중합체를 가함에 의해 감소시킨다. A reagent strip for measuring glucose concentration in whole blood lowers the interference of hematocrit during glucose measurement. When the biological fluid comes in contact with the script, it causes a color change, which is a measure of the glucose concentration in the fluid, among the reagents impregnated in the strip. However, color change is also affected by the red cell concentration (hematocrit), which reduces the accuracy of glucose measurements. The hematocrit effect is reduced by adding an acrylic acid polymer to the reagent.

Dry stick device and method for determining an analyte in a sample

The present invention relates to a dry stick test device for the determination of an analyte in a sample by means of a chemical assay. The device comprises: (i) optionally a solid support, (ii) at least one reagent pad comprising a reagent capable of reacting with the analyte, a derivative of said analyte or an indicator compound for said analyte to provide a detectable signal when in moistened state, and (iii) a development pad which is located in contact with the at least one reagent pad, optionally between the solid support and the at least one reagent pad, said development pad comprises at least one controlling compound capable of providing a condition required for the reagent to react with the analyte to provide a detectable signal, wherein the at least one reagent pad and the development pad are arranged to avoid precipitation of sample component(s) on the top-face of the device.