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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Применить Всего найдено 5. Отображено 5.
27-02-2020 дата публикации

METHOD FOR SYNTHESIZING ENZYME FOR β-GLYCOSIDE OF LACTO-N-BIOSE I OR GALACTO-N-BIOSE USING MODIFIED PHOSPHORYLASE

Номер: WO2020040257A1
Автор: KATAYAMA, Takane, KATOH, Toshihiko, KITAOKA, Motomitsu
Принадлежит:

This application provides: a modified GLNBP protein in which a mutation is introduced to a certain region of a non-mutant GLNBP; and a method of forming a β-1,3 bond between the 1-position of a galactose-1-phosphate using the modified GLNBP, and the 3-position of an N-acetylglucosamine residue or an N-acetylgalactosamine residue in a saccharide having the N-acetylglucosamine residue or the N-acetylgalactosamine residue which is β-bound to a non-reducing end thereof, and also having one or multiple saccharide residues.

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Номер записи: 1
06-03-2014 дата публикации

OLIGOSACCHARIDE SYNTHETASE MANNOSYL-Β-1,4-N-ACETYLGLUCOSAMINE PHOSPHORYLASE AND METHOD FOR PRODUCING CORE SUGAR CHAIN STRUCTURE OF ASPARAGINE-LINKED GLYCOPROTEIN

Номер: WO2014034274A1
Автор: NAKAI, Hiroyuki, NIHIRA, Takanori, SUZUKI, Erika, OHTSUBO, Kenichi, KITAOKA, Motomitsu
Принадлежит:

... [Problem] To efficiently produce a core sugar chain structure of an asparagine-linked glycoprotein. [Solution] A method for easily producing in a single step a core sugar chain structure of an asparagine-linked glycoprotein, said core sugar chain structure being mannosyl-β-1,4-N-acetylglucosamine or mannosyl-β-1,4-kitobiose, through an oligosaccharide synthesis reaction that is catalyzed by mannosyl-β-1,4-N-acetylglucosamine phosphorylase with the use of, as the starting materials, α-mannose 1-phosphate together with N-acetylglucosamine or kitobiose.

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Номер записи: 2
12-07-2018 дата публикации

INTESTINAL MICROFLORA IMPROVING AGENT, AND USE THEREOF

Номер: WO2018128163A1
Автор: NAKAI Hiroyuki, KURIHARA Shin, KATAYAMA Takane, KITAOKA Motomitsu
Принадлежит:

This intestinal microflora improving agent contains, as an active ingredient, galactosyl-β-1,4-rhamnose or an analog thereof, or pharmaceutically acceptable salts of these substances. A pharmaceutical composition for improving intestinal microflora contains the intestinal microflora improving agent and a pharmaceutically acceptable carrier and/or a diluent. A food/beverage includes the intestinal microflora improving agent. A method for promoting the proliferation of Bifidobacterium is a method for administering galactosyl β-1,4-rhamnose or an analog thereof, or pharmaceutically acceptable salts of these substances. A method for inhibiting the proliferation of Clostridium difficile is a method for administering galactosyl β-1,4-rhamnose or an analog thereof, or pharmaceutically acceptable salts of these substances, to a subject carrying Clostridium difficile.

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Номер записи: 3
18-12-2014 дата публикации

PRODUCTION METHOD FOR Β-MANNOSIDE

Номер: WO2014199948A1
Автор: NAKAI, Hiroyuki, NIHIRA, Takanori, OHTSUBO, Kenichi, KITAOKA, Motomitsu
Принадлежит:

Provided is a simple and inexpensive method for producing β-mannoside. This method for producing β-mannoside is characterized in that, in the presence of phosphoric acid, α-phosphoglucomutase (EC 5.4.2.2), glucose-6-phosphate isomerase (EC 5.3.1.9), mannose-6-phosphate isomerase (EC 5.3.1.8), α-phosphomannomutase (EC 5.4.2.8), and cofactors thereof, (i) a combination of a carbohydrate starting material and an enzyme capable of reversible phosphorolysis of the carbohydrate starting material to form α-glucose-1-phosphoric acid, and (ii) a combination of an enzyme capable of reversible phosphorolysis of β-mannoside to form α-mannose-1-phosphoric acid and a substance acting as a sugar acceptor in a reverse reaction thereof, are caused to act.

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Номер записи: 4
03-07-2014 дата публикации

GLUCOSYL-α-1,2-GLYCEROL PHOSPHORYLASE AND METHOD FOR PRODUCING GLUCOSYL-α-1,2-GLYCEROL USING SAME

Номер: WO2014103659A1
Автор: NAKAI, Hiroyuki, NIHIRA, Takanori, SAITO, Yuka, OHTSUBO, Kenichi, KITAOKA, Motomitsu
Принадлежит:

Provided are a novel glucosyl-α-1,2-glycerol phosphorylase that makes it possible to mass-produce glucosyl-α-1,2-glycerol easily and selectively from inexpensive materials, and a method for producing glucosyl-α-1,2-glycerol using the same. According to the present invention, glucosyl-α-1,2-glycerol is mass-produced easily and selectively by (1) conducting an enzymatic reaction in a solution containing β-glucose 1-phosphate, glycerol, and glucosyl-α-1,2-glycerol phosphorylase or (2) conducting an enzymatic reaction in a solution containing a carbohydrate phosphorolytic enzyme that produces β-glucose 1-phosphate, and a sugar that serves as a substrate thereof, and glycerol, phosphoric acid, and glucosyl-α-1,2-glycerol phosphorylase.

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Номер записи: 5